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<entry dataset="TrEMBL" created="1997-07-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O06690</accession>
    <name>O06690_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71308">
        <property type="entry name" value="E71308"/>
    </dbReference>
    <dbReference type="IntAct" id="O06690">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0567"/>
    <dbReference type="EnsemblBacteria" id="AAC65541">
        <property type="protein sequence ID" value="AAC65541"/>
        <property type="gene ID" value="TP_0567"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75754">
        <property type="protein sequence ID" value="AGN75754"/>
        <property type="gene ID" value="TPANIC_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0567"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.563"/>
    <dbReference type="eggNOG" id="COG3334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111537_0_0_12"/>
    <dbReference type="OMA" id="LLWFDYL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23468" checksum="82DAE10350B466EF" modified="1999-05-01" version="2">MRRNSRTMAKIVALLALILLLILAGFIWFDYLGVLDAKRAISPLYRLFGRSVPEGVVSTADPDLDADRYAKRLEALGERAEELDKKDAELQEKEKDHERVSQELDERLRALEDKEKSYNLLVAETNERRGNVRKIAEYVSGMPPESAVKILLKTDDQDVIEVFRMVDAAARQRGVNSLVPYWLSLMPPDRAAEIQRKMANKPADFP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O07886</accession>
    <name>MOTA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Motility protein A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Chemotaxis protein MotA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">motA</name>
        <name type="ordered locus">TP_0725</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="4628" last="4634">
            <title>Organization, transcription, and expression of the 5' region of the fla operon of Treponema phagedenis and Treponema pallidum.</title>
            <authorList>
                <person name="Limberger R.J."/>
                <person name="Slivienski L.L."/>
                <person name="El-Afandi M.C."/>
                <person name="Dantuono L.A."/>
            </authorList>
            <dbReference type="PubMed" id="8755894"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="U28219">
        <property type="protein sequence ID" value="AAB61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71292">
        <property type="entry name" value="A71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882170.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O07886"/>
    <dbReference type="SMR" id="O07886"/>
    <dbReference type="IntAct" id="O07886">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0725"/>
    <dbReference type="EnsemblBacteria" id="AAC65690">
        <property type="protein sequence ID" value="AAC65690"/>
        <property type="gene ID" value="TP_0725"/>
    </dbReference>
    <dbReference type="GeneID" id="57879249"/>
    <dbReference type="KEGG" id="tpa:TP_0725"/>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079895_1_0_12"/>
    <dbReference type="OMA" id="EIETHHQ"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0283">Flagellar rotation</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000189578" description="Motility protein A">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="259" mass="28645" checksum="C14B10A4B6CFB516" modified="1997-07-01" version="1">MDIASFIGLFGGFAIIIFGAVLGGSARGLFHVPSLLITVGGSYLTLFLTYPLSYAVGVFRVIARVFHAADFHEREIVQRLYALAEKSRRTGLLALEEEIQDFDDDFVRTGLRNVVDGVDGDAIKALMESELTHMEDRHNTWISLLNSWAALAPGYGMLGTVMGLIGMLATLEDKSSLGSNMATALITTFYGSLVQNWFITPVATKLQYQHDLEVKSKEMVIEGVLSIQAGDHPRVLAQRLLTYLSPKMRKELEMELIKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O07887</accession>
    <name>MOTB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Motility protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Chemotaxis protein MotB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">motB</name>
        <name type="ordered locus">TP_0724</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="4628" last="4634">
            <title>Organization, transcription, and expression of the 5' region of the fla operon of Treponema phagedenis and Treponema pallidum.</title>
            <authorList>
                <person name="Limberger R.J."/>
                <person name="Slivienski L.L."/>
                <person name="El-Afandi M.C."/>
                <person name="Dantuono L.A."/>
            </authorList>
            <dbReference type="PubMed" id="8755894"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="U28219">
        <property type="protein sequence ID" value="AAB61254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71291">
        <property type="entry name" value="H71291"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882169.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O07887"/>
    <dbReference type="SMR" id="O07887"/>
    <dbReference type="IntAct" id="O07887">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0724"/>
    <dbReference type="EnsemblBacteria" id="AAC65689">
        <property type="protein sequence ID" value="AAC65689"/>
        <property type="gene ID" value="TP_0724"/>
    </dbReference>
    <dbReference type="GeneID" id="57879248"/>
    <dbReference type="KEGG" id="tpa:TP_0724"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_0_1_12"/>
    <dbReference type="OMA" id="NWHLSSA"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0283">Flagellar rotation</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000189590" description="Motility protein B">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="2">
        <location>
            <begin position="35"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="112"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="238" mass="26050" checksum="0AB5FCDBE9852E1F" modified="1997-07-01" version="1">MARKRRAPRGAAQGWLTTYSDMVTLMLCFFVMLFNPTEVDITVLQSIAASIVGDPTGGGVSASSGRLADLGNTVNTLPSLEKGQKLATALKKAVSLFAPEIKSNKIAVTSDERGLVISLTSDSFFYPGSSDLNVEESREALLRVAQFLSDHALAGRRFRIEGHTDSVEVPEDGSTDNWELSTRRAVRVLHYLTDFGAQENRFSLAGYADTRAKFSNESPEGRAYNRRVDIVILDEGHF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O33844</accession>
    <name>DMA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA adenine methylase</fullName>
            <ecNumber>2.1.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA adenine methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Deoxyadenosyl-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>M.TpaI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dam</name>
        <name type="ordered locus">TP_0810</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="FEMS Microbiol. Lett." volume="155" first="115" last="119">
            <title>Identification and characterization of a Treponema pallidum subsp. pallidum gene encoding a DNA adenine methyltransferase.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Greene S.R."/>
                <person name="Barnes N.Y."/>
                <person name="Bergen H.L."/>
                <person name="Hardham J.M."/>
            </authorList>
            <dbReference type="PubMed" id="9345771"/>
            <dbReference type="DOI" id="10.1016/S0378-1097(97)00375-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="Nucleic Acids Res." volume="31" first="1805" last="1812">
            <title>A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.</title>
            <authorList>
                <person name="Roberts R.J."/>
                <person name="Belfort M."/>
                <person name="Bestor T."/>
                <person name="Bhagwat A.S."/>
                <person name="Bickle T.A."/>
                <person name="Bitinaite J."/>
                <person name="Blumenthal R.M."/>
                <person name="Degtyarev S.K."/>
                <person name="Dryden D.T."/>
                <person name="Dybvig K."/>
                <person name="Firman K."/>
                <person name="Gromova E.S."/>
                <person name="Gumport R.I."/>
                <person name="Halford S.E."/>
                <person name="Hattman S."/>
                <person name="Heitman J."/>
                <person name="Hornby D.P."/>
                <person name="Janulaitis A."/>
                <person name="Jeltsch A."/>
                <person name="Josephsen J."/>
                <person name="Kiss A."/>
                <person name="Klaenhammer T.R."/>
                <person name="Kobayashi I."/>
                <person name="Kong H."/>
                <person name="Krueger D.H."/>
                <person name="Lacks S."/>
                <person name="Marinus M.G."/>
                <person name="Miyahara M."/>
                <person name="Morgan R.D."/>
                <person name="Murray N.E."/>
                <person name="Nagaraja V."/>
                <person name="Piekarowicz A."/>
                <person name="Pingoud A."/>
                <person name="Raleigh E."/>
                <person name="Rao D.N."/>
                <person name="Reich N."/>
                <person name="Repin V.E."/>
                <person name="Selker E.U."/>
                <person name="Shaw P.C."/>
                <person name="Stein D.C."/>
                <person name="Stoddard B.L."/>
                <person name="Szybalski W."/>
                <person name="Trautner T.A."/>
                <person name="Van Etten J.L."/>
                <person name="Vitor J.M."/>
                <person name="Wilson G.G."/>
                <person name="Xu S.Y."/>
            </authorList>
            <dbReference type="PubMed" id="12654995"/>
            <dbReference type="DOI" id="10.1093/nar/gkg274"/>
        </citation>
        <scope>NOMENCLATURE</scope>
        <scope>SUBTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3 6">An alpha subtype methylase that recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2 on both strands (Probable) (PubMed:12654995). Directly involved in methyl-directed DNA mismatch repair, DNA replication, and gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72"/>
    <dbReference type="EMBL" id="AF006263">
        <property type="protein sequence ID" value="AAB82782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71277">
        <property type="entry name" value="H71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882255.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O33844"/>
    <dbReference type="SMR" id="O33844"/>
    <dbReference type="IntAct" id="O33844">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0810"/>
    <dbReference type="EnsemblBacteria" id="AAC65779">
        <property type="protein sequence ID" value="AAC65779"/>
        <property type="gene ID" value="TP_0810"/>
    </dbReference>
    <dbReference type="GeneID" id="57879328"/>
    <dbReference type="KEGG" id="tpa:TP_0810"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_0_0_12"/>
    <dbReference type="OMA" id="MNRHGFN"/>
    <dbReference type="OrthoDB" id="1206955at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000087998" description="DNA adenine methylase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0AEE8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="12654995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="9345771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="9345771"/>
        </source>
    </evidence>
    <sequence length="303" mass="33919" checksum="62D2155EAE22DB90" modified="1998-01-01" version="1">MSRSDTARPFVKWAGGKRALAPTLFAHMPQTFGSYFEPFVGGGALFWHLCACTRVRLHDIYLSDINWPLLCAYAAVRDRVEELIVRVGQHIACHTPTYYRLARRKFAVCEHPLEVAALFLYLNRSCYNGLYRVNKAGQFNVPLGRAAPASPFLNTTAPTPRSTQPAAQVGHLAIRIDEENLRSCARALANTTLNCQHFSCIQPARGDFVYLDPPYLGTFSAYDKTGFDRAAHESLAAFCMHLDARGVLFMLSNSDCPEVRAWYRPFRVQQLNAPRCIARSAHARGKRCEVLITNYPCADTATP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O66075</accession>
    <name>RL31_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name type="ordered locus">TP_0255</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Robinson E.J."/>
                <person name="Shevchenko O.V."/>
                <person name="Radolf J.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U95744">
        <property type="protein sequence ID" value="AAC08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71346">
        <property type="entry name" value="D71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881704.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O66075"/>
    <dbReference type="SMR" id="O66075"/>
    <dbReference type="IntAct" id="O66075">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0255"/>
    <dbReference type="EnsemblBacteria" id="AAC65244">
        <property type="protein sequence ID" value="AAC65244"/>
        <property type="gene ID" value="TP_0255"/>
    </dbReference>
    <dbReference type="GeneID" id="57878796"/>
    <dbReference type="KEGG" id="tpa:TP_0255"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_12"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000173174" description="50S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <sequence length="67" mass="7599" checksum="C142F5404DFD6E25" modified="1998-08-01" version="1">MKKGLHPRYEETKVVCACGNVIVTASTVKDLRVEICSACHPFFTGKQKLVDSAGRIDRFNRRYKIRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O66076</accession>
    <name>PGSA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber>2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphatidylglycerophosphate synthase</fullName>
            <shortName>PGP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pgsA</name>
        <name type="synonym">pgs</name>
        <name type="ordered locus">TP_0256</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Robinson E.J."/>
                <person name="Shevchenko O.V."/>
                <person name="Radolf J.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5"/>
    <dbReference type="EMBL" id="U95744">
        <property type="protein sequence ID" value="AAC08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71346">
        <property type="entry name" value="E71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881705.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O66076"/>
    <dbReference type="SMR" id="O66076"/>
    <dbReference type="IntAct" id="O66076">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0256"/>
    <dbReference type="EnsemblBacteria" id="AAC65245">
        <property type="protein sequence ID" value="AAC65245"/>
        <property type="gene ID" value="TP_0256"/>
    </dbReference>
    <dbReference type="GeneID" id="57878797"/>
    <dbReference type="KEGG" id="tpa:TP_0256"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_12"/>
    <dbReference type="OMA" id="FVIFIYR"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000056792" description="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="216" mass="24639" checksum="DC1B9A66D8A85FE3" modified="1998-08-01" version="1">MRLSDFYTALRLALVLPFFALYHMSRWVVMYFPAANVGRVVSIASVLLFLFIACTDFLDGYYARKSGKYSSFGKVFDPFADVIANVTVMLCLVADNFMPVFLFLCILYREFGMMFLRMLACGEGHVVGAQRMGKLKTASYMGAVLFSLLLKALYAFELAGADWYERMRAVGRLVYVVPVVLALASFFSYLKTFFPILKRVCGRTRYPVCKTCREWD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83048</accession>
    <name>DPO3B_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Beta sliding clamp</fullName>
            <shortName>Beta clamp</shortName>
            <shortName>Sliding clamp</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-clamp processivity factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA polymerase III beta sliding clamp subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA polymerase III subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dnaN</name>
        <name type="ordered locus">TP_0002</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71378">
        <property type="entry name" value="A71378"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881452.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83048"/>
    <dbReference type="SMR" id="O83048"/>
    <dbReference type="IntAct" id="O83048">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0002"/>
    <dbReference type="EnsemblBacteria" id="AAC65000">
        <property type="protein sequence ID" value="AAC65000"/>
        <property type="gene ID" value="TP_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="57878544"/>
    <dbReference type="KEGG" id="tpa:TP_0002"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_2_12"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000105476" description="Beta sliding clamp">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="371" mass="41290" checksum="4487E033668063AE" modified="1998-11-01" version="1">MKILCEKEAFLKEISTAQEVISNKKNTSIFSNVLLAAQGALLTIRATDTKVTFETSIPVNVLAEGTTTVFCDKLVNVVSALPTKEIELTLCEEQLVITPPNKKISFQLRTLSHESFPCFPQNEGGVSLAVPTSDLRNMINHTVFAVSEDSTRHFINGVHVDFQYGNIICVSTDGKRLAYIEKKGESSPQSFSGVIVPTKILGIVNRKLTPEGSVTLCITSQHVYFFFGGYKFSSVLIEGQFPNYKRVIPDHQERSFCVGRVELMEALKRVSLLVEQKSHRIFITIQQGLLTLSSKAHTQENEIGDAQEEIACAYTGESEVIALNYLYLEEPLKVFTSKEVQVEFTDPAKALTLRAVPNTDCFHIIMPMQTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O83054</accession>
    <name>Y010_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0010</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71376">
        <property type="entry name" value="G71376"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83054"/>
    <dbReference type="SMR" id="O83054"/>
    <dbReference type="EnsemblBacteria" id="AAC65011">
        <property type="protein sequence ID" value="AAC65011"/>
        <property type="gene ID" value="TP_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0010"/>
    <dbReference type="HOGENOM" id="CLU_3278190_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202173" description="Uncharacterized protein TP_0010">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <sequence length="41" mass="4471" checksum="08178A6F9D5D83FB" modified="1998-11-01" version="1">MGGKKSHFLGRRIEGTGRGVVPFVRKLSEVVKKITADGKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83064</accession>
    <name>O83064_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">76K protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71375">
        <property type="entry name" value="H71375"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881469.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0020"/>
    <dbReference type="EnsemblBacteria" id="AAC65016">
        <property type="protein sequence ID" value="AAC65016"/>
        <property type="gene ID" value="TP_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0020"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.21"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025733_0_0_12"/>
    <dbReference type="OMA" id="HIRIERY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011191">
        <property type="entry name" value="Uncharacterised_Tp_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008381">
        <property type="entry name" value="TP0020_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004160528" evidence="3">
        <location>
            <begin position="26"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="39"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="707" mass="78982" checksum="F1A96F260A144AEA" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83066</accession>
    <name>Y022_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0022</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0022</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71376">
        <property type="entry name" value="B71376"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83066"/>
    <dbReference type="STRING" id="243276.TPANIC_0022"/>
    <dbReference type="EnsemblBacteria" id="AAC65022">
        <property type="protein sequence ID" value="AAC65022"/>
        <property type="gene ID" value="TP_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0022"/>
    <dbReference type="eggNOG" id="ENOG5033VMJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403286_0_0_12"/>
    <dbReference type="OMA" id="HIPVRTI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202178" description="Uncharacterized protein TP_0022">
        <location>
            <begin position="1"/>
            <end position="722"/>
        </location>
    </feature>
    <sequence length="722" mass="80089" checksum="BBA7E917E310F560" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O83072</accession>
    <name>O83072_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemolysin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71374">
        <property type="entry name" value="F71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881477.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0028"/>
    <dbReference type="EnsemblBacteria" id="AAC65024">
        <property type="protein sequence ID" value="AAC65024"/>
        <property type="gene ID" value="TP_0028"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75249">
        <property type="protein sequence ID" value="AGN75249"/>
        <property type="gene ID" value="TPANIC_0028"/>
    </dbReference>
    <dbReference type="GeneID" id="57878570"/>
    <dbReference type="KEGG" id="tpa:TP_0028"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.24"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_12"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503428" evidence="6">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="453" mass="50205" checksum="E411FCE2C0AC7DD9" modified="1998-11-01" version="1">MAYPFLVGLELMFLLVCSALCAGSESALSSVNQDDERKLKRHSTRCTQRLCWLLARREQLITTVIVQNTALNMVLSSVVTLGSMELWGAQSVWKALVAVTCVIILCGEMFPKALGARYSLGFLMWIAPFLQLSYWLLYPCACVSSALMHVLEGIFLPRHTTCLSREEIKTLIAVGAREGVISSTENQLFQRALQFKRIPLAHVMVPHTHFVSVFQDTPLSHVWDAFRTCSFSQLLVHDAAGIVWGFVHYWDIFGESKVLPSQSSDQMVSACVANTRAAVHRVGDLAQELCCVPNVADLFSVLDMLSVSKQQMALVVDERGDGEGLVTMTDIMEVIFGSLAGVSEGVEGYTVHGSMVQRMSKPRVDFQMKSVGTHEILCSGTVPLEYFNEVLGTRLQSRVYHTVGGLLLERFGRLPTVGDELVIEGLRFKIRRVLDRYVVSALVDTRACRSSVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-28" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83080</accession>
    <name>LDHD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>D-lactate dehydrogenase</fullName>
            <shortName>D-LDH</shortName>
            <ecNumber>1.1.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>D-specific 2-hydroxyacid dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ldhD</name>
        <name type="ordered locus">TP_0037</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(R)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:16369"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.28"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71373">
        <property type="entry name" value="D71373"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881486.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="7JP2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.38 A"/>
        <property type="chains" value="A/B=1-331"/>
    </dbReference>
    <dbReference type="PDBsum" id="7JP2"/>
    <dbReference type="AlphaFoldDB" id="O83080"/>
    <dbReference type="SMR" id="O83080"/>
    <dbReference type="IntAct" id="O83080">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0037"/>
    <dbReference type="EnsemblBacteria" id="AAC65033">
        <property type="protein sequence ID" value="AAC65033"/>
        <property type="gene ID" value="TP_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="57878579"/>
    <dbReference type="KEGG" id="tpa:TP_0037"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_1_12"/>
    <dbReference type="OMA" id="PHIAWAY"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="BRENDA" id="1.1.1.28">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000075971" description="D-lactate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="2"/>
            <end position="5"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="37"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="72"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="121"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="147"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="171"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="192"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="218"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="241"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="252"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="turn" evidence="4">
        <location>
            <begin position="265"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="280"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="strand" evidence="4">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="helix" evidence="4">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P26297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P30901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="7JP2"/>
        </source>
    </evidence>
    <sequence length="331" mass="36873" checksum="773B01E6E2384E0A" modified="1998-11-01" version="1">MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDEVYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRHAREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPNDAAKEWLTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVIDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAFYTETAIENMVFNSLDACTTVLRGEPCAAEIKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83092</accession>
    <name>RIR2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber>1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ribonucleotide reductase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nrdB</name>
        <name type="ordered locus">TP_0053</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="1">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71372">
        <property type="entry name" value="G71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881502.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83092"/>
    <dbReference type="SMR" id="O83092"/>
    <dbReference type="IntAct" id="O83092">
        <property type="interactions" value="3"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="RNR_small"/>
    </dbReference>
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        <property type="entry name" value="RNR_small_AS"/>
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    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBORED_SMALL"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000190487" description="Ribonucleoside-diphosphate reductase subunit beta">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="351" mass="41199" checksum="5B373A7FCBBF049A" modified="1998-11-01" version="1">MMESSTILQRRALFNEAGDIELHKRRMVGGNTTNLNDFNNMKYPWVSKWYRQAMNNFWIPEEINMSSDVQDYRNLSAIEKTAYDKILSFLIFLDSIQTANLPNIGQYITANEINLCLTIQAFQEAVHSQSYSYMLDTICSPEERNDILYQWKDDEHLLARNKFIGNLYNEFQDDKSVLALLKVAIANYVLEGIYFYSGFMFFYNLGRNNKMPGSVQEIRYINRDENTHLWLFRSIIQELQKEEPQVFTARNVRLFRDMIREGCEQEIKWGDYVIGDQIPGLNRHMVADYIRYLGNLRCENLGFEPLYEGHRVEPESMSWVSQYSNANLIKTDFFEAKSTAYAKSSAMVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83114</accession>
    <name>O83114_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter, permease protein (Y4oQ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAC65070.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AGN75294"/>
        <property type="gene ID" value="TPANIC_0075"/>
    </dbReference>
    <dbReference type="GeneID" id="57878615"/>
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    <dbReference type="PATRIC" id="fig|243276.9.peg.75"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="296" mass="32951" checksum="E143D88BF7F83FA4" modified="1998-11-01" version="1">MGKSMSKPRDTVSAYCFSAPALVLLMFVLVLPAFLGLRMSFFQWQLSALRTQPVFVGFENYRELFSSIHFWASVRTTLVFTLSVVVLEVVLGLALALVLEHGVPGLRFFRTVFVLPMMIAPVVVGVLWGFLYHPQFGKINYALQAFELGPVLWLANPRLALLSVILTDVWQWTPFVFLVLLAGLQGIPQHLLYAAKVDGANYMQTLLHIKIPHIAPVLGIATVLRLIDSFRGLVVIMTLTNGGPGVATEILPLHLQRIAFEDHRLGKASAVAVLLFLLTSLLTCIFILLTMRRQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83119</accession>
    <name>O83119_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinoline 2-oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="G71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881529.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0080"/>
    <dbReference type="EnsemblBacteria" id="AAC65075">
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        <property type="gene ID" value="TP_0080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75299">
        <property type="protein sequence ID" value="AGN75299"/>
        <property type="gene ID" value="TPANIC_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="57878620"/>
    <dbReference type="KEGG" id="tpa:TP_0080"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.80"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_12"/>
    <dbReference type="OMA" id="QEADDVW"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_2" evidence="1">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17545" checksum="40699B562C8D2D86" modified="1998-11-01" version="1">MNIRFTLNTEQVHVDAMPHERLSTVLRRCFHLPSIKGSHGHGENGASTILFNGEAVSAYIIPFFLAHETQIVTLDFFQKTKRGRWIVACFAQHHISFCGYCDAGKILTAESLLQRNSVPNEEEVRHAFSGMQCRCTDINALIRALQRMPACHEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83123</accession>
    <name>O83123_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, nitrogen regulatory IIA component (PtsN-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71367">
        <property type="entry name" value="F71367"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881534.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83123">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0085"/>
    <dbReference type="EnsemblBacteria" id="AAC65080">
        <property type="protein sequence ID" value="AAC65080"/>
        <property type="gene ID" value="TP_0085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75304">
        <property type="protein sequence ID" value="AGN75304"/>
        <property type="gene ID" value="TPANIC_0085"/>
    </dbReference>
    <dbReference type="GeneID" id="57878625"/>
    <dbReference type="KEGG" id="tpa:TP_0085"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.85"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_5_0_12"/>
    <dbReference type="OMA" id="GIDYNSM"/>
    <dbReference type="OrthoDB" id="1810962at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16311" checksum="55C082D518F0D16F" modified="1998-11-01" version="1">MNLETVLTPETVSLHLKGSTKEEIIDEMLEMFVRAGRVSDKVAARECVLDRERKMSTGMKHGIAIPHGKTNSVSSLVAGVGVSDSPVDFDSLDQEPCRIFIMTLSPLDVTGPHLQFLAEISLLFKSSEKRREILDATSKAEVIKILTE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="151" xmlns="http://uniprot.org/uniprot">
    <accession>O83130</accession>
    <name>O83130_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-24 factor (RpoE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1198269">
            <id>O83130</id>
        </interactant>
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
            <label>dnaB</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71368">
        <property type="entry name" value="E71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881541.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83130">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0092"/>
    <dbReference type="EnsemblBacteria" id="AAC65087">
        <property type="protein sequence ID" value="AAC65087"/>
        <property type="gene ID" value="TP_0092"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75311">
        <property type="protein sequence ID" value="AGN75311"/>
        <property type="gene ID" value="TPANIC_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0092"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.92"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_4_12"/>
    <dbReference type="OMA" id="TNNDYEK"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="162" mass="18997" checksum="6E15DC2D9EDE5ED3" modified="1998-11-01" version="1">MYEQLVPVLYRVAYNVVREEDIAEGLCHDAFIAMTEKRMEFPSLSDAKYWLIRVVKNASLNYAKRRVRERHSCEQASREHVCEPDTGELRLLRIETIEQVRAALDRLPEHLRVVLQLREYGDLNYKEIGRILGISEGNVKVRVFRARERLAKYLGETDAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83147</accession>
    <name>O83147_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71364">
        <property type="entry name" value="D71364"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881558.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83147">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0109"/>
    <dbReference type="EnsemblBacteria" id="AAC65100">
        <property type="protein sequence ID" value="AAC65100"/>
        <property type="gene ID" value="TP_0109"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75328">
        <property type="protein sequence ID" value="AGN75328"/>
        <property type="gene ID" value="TPANIC_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="57878649"/>
    <dbReference type="KEGG" id="tpa:TP_0109"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.110"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_12"/>
    <dbReference type="OMA" id="IFRSAYC"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="292" mass="31207" checksum="775CEF0933E27B51" modified="1998-11-01" version="1">MVISGLRAIEEFLRAQPAALEGLHAGGKNSKTQQSCVRVLTLYYAAENARIKRLLGMAAARGIRITHTTCAVLDKLARSLPPALRDHRGILAVLSSPSATPQGSHTRKKRPAVDSSQERTLLHALATHTHALVLVLDAITDPHNVGAIVRSADQFSVDAVLLPHHHGAGGTETITRVSAGAVAWVPLVRVRNLVRTAGILKRSGFWLYGADVAGEAIGARTFPPKTALVLGNEGHGVSPLLRTHCDALISIPTQGNVDSLNVSVAAGILLYEIRRSQQSPYSVQRQNEMNAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83151</accession>
    <name>HFLK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hflK</name>
        <name type="ordered locus">TP_0113</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text>HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71364">
        <property type="entry name" value="H71364"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881562.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83151"/>
    <dbReference type="IntAct" id="O83151">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0113"/>
    <dbReference type="EnsemblBacteria" id="AAC65102">
        <property type="protein sequence ID" value="AAC65102"/>
        <property type="gene ID" value="TP_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0113"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039173_0_1_12"/>
    <dbReference type="OMA" id="WNEPGGN"/>
    <dbReference type="OrthoDB" id="577287at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000094088" description="Protein HflK">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="328" mass="36967" checksum="F6CDDBAA5DC20B31" modified="1998-11-01" version="1">MRIPKWTPATWSVVAGCIGGVLGIVIVGIASPIRIISPTDNGVVTRFGKYHRTLEPGLHYLIPFVEWVYKVPVTKVQKEEFGFRTSKSSEQSHYVNNISHESLMLTGDLNIVDVEWVVQYRIVDPRAWVFNVESQERRQTIRDISKAVVNSLIGDRAILDIMGPERSAIQMRAKDMMNVLLKRIGLGVLVSSVQLQNVVPPQEVQQAFEDVNIAIQDMNRLINEGKESYNREIPKARGDADKLIQEAMGYANERVNRAKGDVARFDSIYAEYVKAPHVTKTRLYLEGLGAILEKTENVLLIDKKLENLLTLKDISKVSKKVVAGTREE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83160</accession>
    <name>Y123_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>TPR repeat-containing protein TP_0123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0123</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71364">
        <property type="entry name" value="B71364"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83160"/>
    <dbReference type="SMR" id="O83160"/>
    <dbReference type="STRING" id="243276.TPANIC_0123"/>
    <dbReference type="PRIDE" id="O83160"/>
    <dbReference type="EnsemblBacteria" id="AAC65115">
        <property type="protein sequence ID" value="AAC65115"/>
        <property type="gene ID" value="TP_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0123"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347775_0_0_12"/>
    <dbReference type="OMA" id="NITEYLW"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <feature type="chain" id="PRO_0000106453" description="TPR repeat-containing protein TP_0123">
        <location>
            <begin position="1"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <sequence length="856" mass="97894" checksum="7C4B85E2F2463278" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83195</accession>
    <name>SYP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">TP_0160</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71359">
        <property type="entry name" value="F71359"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83195"/>
    <dbReference type="SMR" id="O83195"/>
    <dbReference type="IntAct" id="O83195">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0160"/>
    <dbReference type="EnsemblBacteria" id="AAC65149">
        <property type="protein sequence ID" value="AAC65149"/>
        <property type="gene ID" value="TP_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0160"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_12"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000139348" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="617" mass="68193" checksum="F6CAA433AE604A8E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83203</accession>
    <name>Y173_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0173</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0173</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71358">
        <property type="entry name" value="B71358"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881620.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83203"/>
    <dbReference type="STRING" id="243276.TPANIC_0172"/>
    <dbReference type="EnsemblBacteria" id="AAC65163">
        <property type="protein sequence ID" value="AAC65163"/>
        <property type="gene ID" value="TP_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0173"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219262_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202205" description="Uncharacterized protein TP_0173">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="227" mass="25261" checksum="D2878E9B8E15FE3D" modified="1998-11-01" version="1">MYFAILGTMSRTCVRAYAVFAIAIMVLTVAWFAFSISQAIQRNTVGAQQRFAQVIRRIAPRVTSKRQLTDAEADFIQNLCKNDDLIMALNIFSNRVQLFSWTYDDLMFVAGGGSELVPRSSSLFIKIFSGRVPYQAKDECLLFTAALRVLTPANIFFRGCVVFLVMLTLTISSMVFLVIEYLSVRRFQCAQGDARPRPAGPQGTARSRTDEAQVSPGTPPECPVSVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83208</accession>
    <name>Y178_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0178</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0178</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71353">
        <property type="entry name" value="D71353"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881625.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83208"/>
    <dbReference type="STRING" id="243276.TPANIC_0178"/>
    <dbReference type="EnsemblBacteria" id="AAC65192">
        <property type="protein sequence ID" value="AAC65192"/>
        <property type="gene ID" value="TP_0178"/>
    </dbReference>
    <dbReference type="GeneID" id="57878717"/>
    <dbReference type="KEGG" id="tpa:TP_0178"/>
    <dbReference type="eggNOG" id="ENOG5030KHU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902963_0_0_12"/>
    <dbReference type="OMA" id="GEDICSK"/>
    <dbReference type="OrthoDB" id="1485160at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202209" description="Uncharacterized protein TP_0178">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <sequence length="308" mass="34684" checksum="78E64738CBDEE4C0" modified="1998-11-01" version="1">MGLIARASRIRRSSGVSCEYYRLELQFVQLVESLGIPRAGFLFLTEERMFDLRFPFGIDTTTFYRMRVPTSLLSPGLPAEQWTTLFRQELTELQGYFSSHLFSTLRALHLYPFSAGSVRVYLVLFDTRTDVEEGALAADLHGDASGEERVRSFILAVQARFSFIEASRPVYPRQPELAPSCSQLEFALNNQRMANLFTISINQSALPPAVLQEELSMVRRCCALSNQLLTLVGNDNLASCVASRELRVVVFSSFPVDPELYLNQLTRGVSAYFVNHAENSLLITSSGTTRAQTDVLRFLQYETGETCR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O83217</accession>
    <name>EFTU_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name type="ordered locus">TP_0187</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65172" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65172.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71354">
        <property type="entry name" value="E71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881634.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83217"/>
    <dbReference type="SMR" id="O83217"/>
    <dbReference type="IntAct" id="O83217">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0187"/>
    <dbReference type="PRIDE" id="O83217"/>
    <dbReference type="EnsemblBacteria" id="AAC65172">
        <property type="protein sequence ID" value="AAC65172"/>
        <property type="gene ID" value="TP_0187"/>
    </dbReference>
    <dbReference type="GeneID" id="57878725"/>
    <dbReference type="KEGG" id="tpa:TP_0187"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_12"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091429" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="395" mass="43260" checksum="7486CD4DE9655AC5" modified="2000-05-30" version="2">MAKEKFARTKVHMNVGTIGHVDHGKTTLSAAITSYCAKKFGDKQLKYDEIDNAPEEKARGITINTRHLEYQSDRRHYAHIDCPGHADYVKNMITGAAQMDGGILVVSAPDGVMPQTKEHLLLARQVGVPSIIVFLNKVDLVDDPELLELVEEEVRDALAGYGFSRETPIVKGSAFKALQDGASPEDAACIEELLAAMDSYFEDPVRDDARPFLLSIEDVYTISGRGTVVTGRIECGVISLNEEVEIVGIKPTKKTVVTGIEMFNKLLDQGIAGDNVGLLLRGVDKKEVERGQVLSKPGSIKPHTKFEAQIYVLSKEEGGRHSPFFQGYRPQFYFRTTDITGTISLPEGVDMVKPGDNTKIIGELIHPIAMDKGLKLAIREGGRTIASGQVTEILL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83219</accession>
    <name>RL3_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name type="ordered locus">TP_0189</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71354">
        <property type="entry name" value="G71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881636.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83219"/>
    <dbReference type="SMR" id="O83219"/>
    <dbReference type="STRING" id="243276.TPANIC_0189"/>
    <dbReference type="EnsemblBacteria" id="AAC65174">
        <property type="protein sequence ID" value="AAC65174"/>
        <property type="gene ID" value="TP_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0189"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_12"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000077182" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="208" mass="22783" checksum="827F7CBA616678CC" modified="1998-11-01" version="1">MVGLIGQKVGMTQIFDARGCVTPVTVIRVEHNVVVGLKDVERFGYSAVILGTGCMKKSRISKPYAGQFAERIPPVRVMREFRGFTLDVSVGQVLDVRVLESVRYLDVCALSKGKGFQGVVKRWGFSGGRSSHGSKFHREAGSTGQCTSPGRTFKNVKMPGRMGAERVTVQNLRIERIDVGLGVVMVRGAVPGRNKATVFLRTAVKRER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83226</accession>
    <name>RL16_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">TP_0196</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71355">
        <property type="entry name" value="F71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881643.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83226"/>
    <dbReference type="SMR" id="O83226"/>
    <dbReference type="STRING" id="243276.TPANIC_0196"/>
    <dbReference type="EnsemblBacteria" id="AAC65181">
        <property type="protein sequence ID" value="AAC65181"/>
        <property type="gene ID" value="TP_0196"/>
    </dbReference>
    <dbReference type="GeneID" id="57878734"/>
    <dbReference type="KEGG" id="tpa:TP_0196"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_12"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000062240" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <sequence length="139" mass="15706" checksum="E679D8F85D319E38" modified="1998-11-01" version="1">MALSPKRVKYRKVQRGRVKGDATRCNAVDFGAYALVCLEPFWLTSRQIEAARVALNRRIKRGGKLWIRVFPDKPYSKKPAETRMGKGKGSPEYWVAVVKPGTVLFELMGVERALAEQAMLLAGSKLPIKTRFAERVQEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83241</accession>
    <name>RS11_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">TP_0211</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71352">
        <property type="entry name" value="A71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881659.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83241"/>
    <dbReference type="SMR" id="O83241"/>
    <dbReference type="IntAct" id="O83241">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0211"/>
    <dbReference type="EnsemblBacteria" id="AAC65200">
        <property type="protein sequence ID" value="AAC65200"/>
        <property type="gene ID" value="TP_0211"/>
    </dbReference>
    <dbReference type="GeneID" id="57878749"/>
    <dbReference type="KEGG" id="tpa:TP_0211"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_12"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000123249" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="126" mass="13739" checksum="78650B2C837DCF17" modified="1998-11-01" version="1">MAVTKKRKEKKNVYEGNVYIQATFNNTIITVTDLQGNALSWASSGGLGFNGAKKSTPFAAQTVAEAAVQKAQQCGLREVHVFVKGPGIGRESAIRMLGTMGLRVRSIRDITPIPHNGCRPRKTRRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83243</accession>
    <name>RL17_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">TP_0213</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71352">
        <property type="entry name" value="C71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881661.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83243"/>
    <dbReference type="SMR" id="O83243"/>
    <dbReference type="IntAct" id="O83243">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0213"/>
    <dbReference type="EnsemblBacteria" id="AAC65202">
        <property type="protein sequence ID" value="AAC65202"/>
        <property type="gene ID" value="TP_0213"/>
    </dbReference>
    <dbReference type="GeneID" id="57878751"/>
    <dbReference type="KEGG" id="tpa:TP_0213"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_1_12"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000175548" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="164" mass="18666" checksum="B71EB7C5B91778DA" modified="1998-11-01" version="1">MRHRTGFNPLSCMAAHRRALRRNMVTSLFKFERITTTKPKAAEVRRAAERLITRSKSDSVHNRRQVARFIWDKAVLHKLFADIGPRMREREGGYTRILKLGLRQGDAAHVVVLELVDYTFEKSLKKRARTDSVPARKGAGKKDASRVSGTVPDGQSQKIGKKKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83268</accession>
    <name>RL7_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">TP_0240</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71350">
        <property type="entry name" value="B71350"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881688.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83268"/>
    <dbReference type="SMR" id="O83268"/>
    <dbReference type="IntAct" id="O83268">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0240"/>
    <dbReference type="EnsemblBacteria" id="AAC65228">
        <property type="protein sequence ID" value="AAC65228"/>
        <property type="gene ID" value="TP_0240"/>
    </dbReference>
    <dbReference type="GeneID" id="57878782"/>
    <dbReference type="KEGG" id="tpa:TP_0240"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_12"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000157599" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="129" mass="13338" checksum="AF2A0E7454B2F322" modified="1998-11-01" version="1">MAALSNEQIIEAIRGKTILELSELIKAVEEEFGVTAAVPVAPVAEGGGAGSVAAEEQTEFTVVLKGLAEPGKKIAVIKEVRNVISGLGLKEAKDLVEGAPKTLKENVSKEEAAKIKESMTAAGALIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83300</accession>
    <name>O83300_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71342">
        <property type="entry name" value="G71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881725.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83300">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0276"/>
    <dbReference type="EnsemblBacteria" id="AAC65264">
        <property type="protein sequence ID" value="AAC65264"/>
        <property type="gene ID" value="TP_0276"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75487">
        <property type="protein sequence ID" value="AGN75487"/>
        <property type="gene ID" value="TPANIC_0276"/>
    </dbReference>
    <dbReference type="GeneID" id="57878820"/>
    <dbReference type="KEGG" id="tpa:TP_0276"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.280"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_3_0_12"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="294" mass="32961" checksum="E9D09A5B8D3EE1AC" modified="1998-11-01" version="1">MVLSHSVRRAQRVDIMKQLLITAEPDSGGYVQLSGKDFHYMVRVRRARVGDTFTLRTQAGAQYSAVVSALDIHTRSLILHCTPMPPVDEKTQVTLVLLQWMPRARVFDAIVRHATELGTARIIPIRGERSLIRDEKDTQHARLQRIVREARQQSGSAVNTRVDTLHSLLGALHMLEQEFPYPSAVRIYCSEKHVGGSFHELLWTGRSTHCTAHRTPTEPNAPHNTPDVRAQAVILAVGAEGGFSDTEERTLHDAHFAPLHFRTNVLRVETAALYALAGAHLLLSEAALWNKRSW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83309</accession>
    <name>Y285_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0285</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0285</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71343">
        <property type="entry name" value="H71343"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881734.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83309"/>
    <dbReference type="SMR" id="O83309"/>
    <dbReference type="STRING" id="243276.TPANIC_0284"/>
    <dbReference type="EnsemblBacteria" id="AAC65281">
        <property type="protein sequence ID" value="AAC65281"/>
        <property type="gene ID" value="TP_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0285"/>
    <dbReference type="eggNOG" id="COG0731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035710_0_0_12"/>
    <dbReference type="OMA" id="REPKNTY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027608">
        <property type="entry name" value="Spiro_SPASM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04321">
        <property type="entry name" value="spiroSPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202227" description="Uncharacterized protein TP_0285">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <sequence length="359" mass="41255" checksum="ABD869B1BBC26E6D" modified="1998-11-01" version="1">MFCTSFIFESIKTDINSFDLETMIAPVDVRHLRLEFYTSSKAQFLQCAAFTDITAENYAQLISAREHALRTVPAYYALELTRAYPLSSLYRPVSFPAQVENASLMPKEEACALIRRIADFSERAVISLSVFGDPVLYPALCDVVREILKYPGLSVLIETSGLGWQESVVRDLCECARNSARTPFAIGWIVFLDAVSSGMYSQVHRVSLSEAEFFLKEATEFAMQVHAQCPGVLWPQIFRMNENEKELEPFYRTWKERVGQVIVQKYDHVCGLLPDRRVADLSPLERYPCWHLKRDMIIFTDGRVPLCKEDVHCRHALGNAFQQDLAQIWRRGQDVYLQHVRAVHEGLCGQCDEYYTYNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83344</accession>
    <name>Y324_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0324</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0324</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71338">
        <property type="entry name" value="G71338"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83344"/>
    <dbReference type="STRING" id="243276.TPANIC_0324"/>
    <dbReference type="EnsemblBacteria" id="AAC65316">
        <property type="protein sequence ID" value="AAC65316"/>
        <property type="gene ID" value="TP_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0324"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562495_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202236" description="Uncharacterized protein TP_0324">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="485" mass="53603" checksum="C16B3AC11B69DEDF" modified="1998-11-01" version="1">MAVLPSVRRFECSLFVVLVLCALAVFDPLSGFVQQKLAGVQRVWLGLVEEYSGLRFQYDSLSPSVLRAVTLRNVRVREAVRGEQVAVFSKIVVAYNIFSLFGSNPVRGIRALHVHDGAVDVDLYRHRHVKEKLQKLFSKDGEMASFFADLREIDVRVHNTAVTVRSDSRRAHLSVPQGRFSFAETGASFALSCEAEYVDTRSSSWGPLYTHLDASGVFETSFTSGSATLELAPPSGSFFSVPTLTLVAIYADDLFKFHTARGIYPMEVSGQWNTATGACEASVRCENFRPLKWARLRDTHVPAQGMQELSVSGNVQVGYTPIEQWRWSADVHAHTPYVVLAPGYQLEDVVATLQAHGDPARIQVEKICARGSNLDVDGAFELTLDRWIPSGVLTVHRLPLLSGAYLSAQVRFRPQGVGFVCTVPRIQVGEAFLEDVALSVRVDPAKTDFRLVAADSTGRYECDGSYLAANAGSLAFLRHTWRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83356</accession>
    <name>O83356_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComE protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71337">
        <property type="entry name" value="F71337"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881784.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83356">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0336"/>
    <dbReference type="EnsemblBacteria" id="AAC65322">
        <property type="protein sequence ID" value="AAC65322"/>
        <property type="gene ID" value="TP_0336"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75534">
        <property type="protein sequence ID" value="AGN75534"/>
        <property type="gene ID" value="TPANIC_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0336"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.334"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="KVITIRQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ComEC_N"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="289"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="566" mass="60906" checksum="9D47E9A44ADE228D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83362</accession>
    <name>KCY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Cytidylate kinase</fullName>
            <shortName>CK</shortName>
            <ecNumber>2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cytidine monophosphate kinase</fullName>
            <shortName>CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cmk</name>
        <name type="ordered locus">TP_0342</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65330" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.4.25"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65330.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71335">
        <property type="entry name" value="E71335"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83362"/>
    <dbReference type="IntAct" id="O83362">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0342"/>
    <dbReference type="EnsemblBacteria" id="AAC65330">
        <property type="protein sequence ID" value="AAC65330"/>
        <property type="gene ID" value="TP_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0342"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_12"/>
    <dbReference type="OMA" id="FIFRDMA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000132030" description="Cytidylate kinase">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="174" mass="19505" checksum="15A72F725641797A" modified="2000-12-01" version="2">MRIAVSGASGCGNTTVSALLAERLGLPLVNYTFRNIARELGISLSEVLERARTDNHFDKAVDARQLCLAMRSSCVVGSRLAIWLVKDAALKVYLLASLKERVKRVLQREGGDVQDVERFTSMRDAEDMSRYKKLYRIDNTNYSFADLVLNTEGCDQETVVSIIIEMLRARGIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83407</accession>
    <name>O83407_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71332">
        <property type="entry name" value="B71332"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0392"/>
    <dbReference type="EnsemblBacteria" id="AAC65376">
        <property type="protein sequence ID" value="AAC65376"/>
        <property type="gene ID" value="TP_0392"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75586">
        <property type="protein sequence ID" value="AGN75586"/>
        <property type="gene ID" value="TPANIC_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0392"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.392"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075574_0_0_12"/>
    <dbReference type="OMA" id="FALSTMY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="319" mass="37033" checksum="2FCAC9A683774B07" modified="1998-11-01" version="1">MKSAQGWRRTFIRFAIHMRRICLQAVSIYIRFSVCSAMQILQLPRCTHTWKMDSSKRVTARVFLQKVFVMKTRRCASYVGGALCAAFFFFHSCKERRTVQRVQDLEKGVPHPTSIEELRRAVKLHEQRLERLHAVQDQVGVWYKMLALRYFDRKMYTHALDAFTQAITFAPENKHLFFYQALCAAYAAKYVAPIDPEKKMQQQAAYRALAVSAYVRALSLDAQYSHALYGLSVLYVFELNQPQNAVPHLQKLLELKENTEAALFVLARAYYTLGRYAQAIECYDRILVQSSDSHQRDRARQNKELVTNVSQRATRGDRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83462</accession>
    <name>UPP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative uracil phosphoribosyltransferase</fullName>
            <ecNumber>2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">upp</name>
        <name type="ordered locus">TP_0448</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPRTase family. Highly divergent.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71324">
        <property type="entry name" value="H71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881896.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83462"/>
    <dbReference type="SMR" id="O83462"/>
    <dbReference type="STRING" id="243276.TPANIC_0448"/>
    <dbReference type="EnsemblBacteria" id="AAC65434">
        <property type="protein sequence ID" value="AAC65434"/>
        <property type="gene ID" value="TP_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="57878972"/>
    <dbReference type="KEGG" id="tpa:TP_0448"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_12"/>
    <dbReference type="OMA" id="PSMIMSK"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120907" description="Putative uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="242"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="360" mass="41018" checksum="9E2CAB2E2FA3768C" modified="1998-11-01" version="1">MEGQTARRVITEAKFLDDCLTERDSYYLSKLDELYSSAMSSFAQFEDQQNGARSARAEENIIATYDSIGNLMQEICKELPALKVYSFETQRENHAEVSRVVSKLRNIHTGYSEFIYYTQRAFEMLFRLAYGGSHEEHKTYLITKTPVAFPVQNYAVHKIANVDYKIENTVMCVMLRGALLPSMIVSKEIEEYSSHGYVTPFALFKIKRDDLRDERDMQYVFDLDKSYFSARELDGKDLVFADPMNATGGSLVTIVRYLQDLGVKPKSISCFHMISALKGAIRVVRSLENCTVYTLWMDPVLNARAYIMPGLGDAGDRVNGVDVEDYPRNIIQLLADYGSNISGLYRSQLRKIEETVLGSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83469</accession>
    <name>Y456_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0456</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0456</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71323">
        <property type="entry name" value="A71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881905.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83469"/>
    <dbReference type="STRING" id="243276.TPANIC_0456"/>
    <dbReference type="EnsemblBacteria" id="AAC65445">
        <property type="protein sequence ID" value="AAC65445"/>
        <property type="gene ID" value="TP_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="57878980"/>
    <dbReference type="KEGG" id="tpa:TP_0456"/>
    <dbReference type="eggNOG" id="ENOG5032P03">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064740_0_0_12"/>
    <dbReference type="OMA" id="CANKEAE"/>
    <dbReference type="OrthoDB" id="731392at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014250" description="Uncharacterized lipoprotein TP_0456">
        <location>
            <begin position="21"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="438" mass="47352" checksum="7CA919FBF0D651D6" modified="1998-11-01" version="1" precursor="true">MNTRLALVLCAVGSGVLSFSCARTAEPTPAASTHVPVTTAGALSVTPPSSTDRWYQFSRTDGRVHLRACPAPSQPSAPEHFVPWTEAVRLSAVDAQQELLLINRAGVLPATQLARMQTAPVPRKAPSTPAAETTSLTLTPPALLATQSAEGFYSEPIPNSSPHPCQGTGAVFVRLYTDPLFTTSPQDSAAPFLVRYDVRTARWTSVAYTRALGLPRNAQCTALTHTRGTWYASFKSSEAERVSFAYFSFPSLSSLENLGPTQRREHPIGGKVQVPRPISAAAFRAACTPQRLHLPTASTSSDHHSDLHELLVHRLLARVPLSPLYLSARSPCWASDRSFLKTAHRTADERAHHANALIFHPPRARLSAALLTDSGHLYFVREDGSEGHARLSALPPQFVYTSFTLSGPSLIAGWEEQDFFQVGSTGLLCTEVESLTGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83480</accession>
    <name>Y467_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0467</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0467</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71321">
        <property type="entry name" value="E71321"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881916.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83480"/>
    <dbReference type="IntAct" id="O83480">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0467"/>
    <dbReference type="EnsemblBacteria" id="AAC65458">
        <property type="protein sequence ID" value="AAC65458"/>
        <property type="gene ID" value="TP_0467"/>
    </dbReference>
    <dbReference type="GeneID" id="57879578"/>
    <dbReference type="KEGG" id="tpa:TP_0467"/>
    <dbReference type="HOGENOM" id="CLU_2557279_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202260" description="Uncharacterized protein TP_0467">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <sequence length="82" mass="9614" checksum="FDA6A0CEE370890C" modified="1998-11-01" version="1">MNSYFSALPLKCVRRPFILSRNEGWGIKRFYVADEPHRSFLCMQEGVRRGGGESEITQRKADVLRKSIRSADRYKEDRSCRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83487</accession>
    <name>Y474_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein TP_0474</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0474</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71318">
        <property type="entry name" value="H71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881923.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83487"/>
    <dbReference type="SMR" id="O83487"/>
    <dbReference type="IntAct" id="O83487">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0474"/>
    <dbReference type="EnsemblBacteria" id="AAC65461">
        <property type="protein sequence ID" value="AAC65461"/>
        <property type="gene ID" value="TP_0474"/>
    </dbReference>
    <dbReference type="GeneID" id="57878995"/>
    <dbReference type="KEGG" id="tpa:TP_0474"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_12"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000175922" description="Probable transcriptional regulatory protein TP_0474">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="245" mass="26326" checksum="EE57DDB2031B50D5" modified="1998-11-01" version="1">MSGHSKWATIKHAKGAADAKRGQLFTKFIKEISVAARMAGGDPQANPRLRTAILKARAANMPKDNIERAIKKGTGELSGSSYEELVYEGYAPGGVAVLVEVLTDNKNRAAANVRNLFSRNGGNLGSAGSVSYMFNRKGVIEYDSEQVDEEALMELALEAGAEDIQNAGGVLTVTTVPGTFETVLESLQAKGWESLSAGISMVPDTYLALDEETARKVLKMIDRLEEEEDVQAVYSNADIPSELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83492</accession>
    <name>O83492_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71319">
        <property type="entry name" value="E71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881928.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83492">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0479"/>
    <dbReference type="EnsemblBacteria" id="AAC65468">
        <property type="protein sequence ID" value="AAC65468"/>
        <property type="gene ID" value="TP_0479"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75671">
        <property type="protein sequence ID" value="AGN75671"/>
        <property type="gene ID" value="TPANIC_0479"/>
    </dbReference>
    <dbReference type="GeneID" id="57879000"/>
    <dbReference type="KEGG" id="tpa:TP_0479"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.477"/>
    <dbReference type="HOGENOM" id="CLU_1304419_0_0_12"/>
    <dbReference type="OMA" id="LTWSSIW"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="224" mass="24238" checksum="6265D3722F492235" modified="1998-11-01" version="1">MTLSHPTREDRPSRRVLQLGLDRMGIQWHTARGGVRARCVVRVGSLLAALGMGAGVFAAEVFVSPKVGQVGAHPWGKEPAPRTDVLLYTPTLGLAVGVIAHNGFAFTTELDAGLAFLMFRAQFLVGWAIRSGKNFAFIPSLGVDILSTQDDKLVGIPINLDFLIFFTKHVGLDFTFGSGVNVPLTKNLKKGANGNGQDLTWSNIWAKYCCTSLVMVKIGPVFRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83496</accession>
    <name>Y483_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0483</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0483</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71320">
        <property type="entry name" value="A71320"/>
    </dbReference>
    <dbReference type="IntAct" id="O83496">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0483"/>
    <dbReference type="EnsemblBacteria" id="AAC65472">
        <property type="protein sequence ID" value="AAC65472"/>
        <property type="gene ID" value="TP_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0483"/>
    <dbReference type="HOGENOM" id="CLU_683226_0_0_12"/>
    <dbReference type="OMA" id="QVHRRCA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014251" description="Uncharacterized protein TP_0483">
        <location>
            <begin position="22"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="374" mass="42129" checksum="D4DC031C6C31022E" modified="1998-11-01" version="1" precursor="true">MSIISRVCIPCAVLLFAQLHAKELVHVSQLKEQEARISWQEVPGAVSYRVLIRNAHGRIVTNAVATTRSYSFSRLRPGSYQYQIIAYDVLHRASASAWTSLSIEKVHKPKTGGITPSTIEHVVGGEAYTVVXDRXWTYEKGWTIALFPDDKADEAGAYVKPLSVSKNKEGNWMVAIPNAALKTGSYTLRAITPRNIYAEVRGILHVVLWRRPIFFYYDLSVGYAPVYRPQDHAATINGVSDFFKICSPIGFVGTFEMCFFKRNSSTISAGFNAQMHSDSKQVDVKLDGNFAYLYELYPRIEVGGMLGLGYSLPFGQRKEDDSMYSYVTGTMKYFFTNSIYLRVQQQHMLTVKPSFTGVSLQQTPSLSFGYRFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83507</accession>
    <name>O83507_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71318">
        <property type="entry name" value="F71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881943.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0494"/>
    <dbReference type="EnsemblBacteria" id="AAC65481">
        <property type="protein sequence ID" value="AAC65481"/>
        <property type="gene ID" value="TP_0494"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75685">
        <property type="protein sequence ID" value="AGN75685"/>
        <property type="gene ID" value="TPANIC_0494"/>
    </dbReference>
    <dbReference type="GeneID" id="57879016"/>
    <dbReference type="KEGG" id="tpa:TP_0494"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.491"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_2_1_12"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="273" mass="31433" checksum="2BFDEF45C405682A" modified="1998-11-01" version="1">MVPANVFENLRALQVVLAQKNRLETEIAEAPKFLVAQEELLTRCKESFIEKNVEYESVREEVARLTTELCKAEKRREDAEVAMDNISTQREYDALDREIQEAKRQEVALRSEVARSDVAYKRLAEEIKLDQEDIVQQERELTENKARVDAEVRGKREQVLRLQEEERRLSPDLDRDVLFKFERIIKSKQGVGIVPVRGNVCAGCHMILPAQFSTGVREGNSIVYCPYCSRILYYEETDEPEMTFFDEEDLGSLSDLVYPEESGGFGGGDREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83522</accession>
    <name>O83522_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TP_0509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="D71314"/>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0509"/>
    <dbReference type="EnsemblBacteria" id="AAC65497">
        <property type="protein sequence ID" value="AAC65497"/>
        <property type="gene ID" value="TP_0509"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75698">
        <property type="protein sequence ID" value="AGN75698"/>
        <property type="gene ID" value="TPANIC_0509"/>
    </dbReference>
    <dbReference type="GeneID" id="57879032"/>
    <dbReference type="KEGG" id="tpa:TP_0509"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.504"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_12"/>
    <dbReference type="OMA" id="WWPKDFT"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="BRENDA" id="1.11.1.24">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAC65497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="188" mass="20709" checksum="44D2CFDFA3420AFE" modified="1998-11-01" version="1">MESLIGKRVIDFKLPAYVGGKFTEVSNASIKGSWAVFMFYPADFTFVCPTELADLARVYPSFVEIGCKVYSVSTDSEYVHKAWADATDTIKNLPYEMISDKAGKLAGFFGVLLPDTWHALRGTFVVDPEGLVKAFEVHDMGIGRDADELLRKVQSAQFVAKHGDQVCPARWKPGAKTLKPGIDLIGKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83529</accession>
    <name>MURJ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murJ</name>
        <name type="synonym">mviN</name>
        <name type="ordered locus">TP_0516</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71315">
        <property type="entry name" value="C71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881965.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83529"/>
    <dbReference type="SMR" id="O83529"/>
    <dbReference type="IntAct" id="O83529">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0516"/>
    <dbReference type="EnsemblBacteria" id="AAC65504">
        <property type="protein sequence ID" value="AAC65504"/>
        <property type="gene ID" value="TP_0516"/>
    </dbReference>
    <dbReference type="GeneID" id="57879039"/>
    <dbReference type="KEGG" id="tpa:TP_0516"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_0_12"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000182017" description="Probable lipid II flippase MurJ">
        <location>
            <begin position="1"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <sequence length="526" mass="58052" checksum="A80B8434ECBC5D94" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83533</accession>
    <name>O83533_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III, gamma and tau subunits, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71315">
        <property type="entry name" value="G71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881969.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83533">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0521"/>
    <dbReference type="EnsemblBacteria" id="AAC65508">
        <property type="protein sequence ID" value="AAC65508"/>
        <property type="gene ID" value="TP_0521"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75709">
        <property type="protein sequence ID" value="AGN75709"/>
        <property type="gene ID" value="TPANIC_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0521"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.517"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052177_0_0_12"/>
    <dbReference type="OMA" id="QEIRASW"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="423" mass="48235" checksum="3FEEED69D47024C7" modified="1998-11-01" version="1">MFENIVGQPATDLLRDDVMHARLPAALLFVGPPASGKLTAALELARVLSCTQGGVWQCPCAPCVQHTELLSPELLVMGIKDLILEIRASARAYMSVHTQGTRYLFVRAVRKLITRFDERLWDSDDTRFSAAVSSIAELDQELASLPAQGDRRTTPEQKERVQRICVIAERLQQESLYTQLPVQQIRNAIQWVRLTPSGRKKVLIIEHAHAMHESARTAFLKILEEPPRDTLFILTTATKYAIMPTVLSRVRSYSFRERSVELQCAVITRVFHDRPTDAKNTQGVLLHYLYQFLSFSLEEVQTSVMYFWLYVCQHARCIGRIIPDTWVSVGTQPQVSGMDLTSLDSTLHFFQAHKQQHAVSLFFSLLVRHMRTLQRTTEYSARNTECFAHIAHCIEQAHRNVQLWNLTIQGTLEHLAHTIANHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83537</accession>
    <name>EFP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor P</fullName>
            <shortName>EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">efp</name>
        <name type="ordered locus">TP_0525</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text>Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71312">
        <property type="entry name" value="G71312"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881973.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83537"/>
    <dbReference type="SMR" id="O83537"/>
    <dbReference type="IntAct" id="O83537">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0525"/>
    <dbReference type="EnsemblBacteria" id="AAC65512">
        <property type="protein sequence ID" value="AAC65512"/>
        <property type="gene ID" value="TP_0525"/>
    </dbReference>
    <dbReference type="GeneID" id="57879048"/>
    <dbReference type="KEGG" id="tpa:TP_0525"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_2_12"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094360" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="187" mass="21043" checksum="49587D4560678ECA" modified="1998-11-01" version="1">MIRGGDIAKGTVLLHKGAPYLVVEREFVNPGKGAAFARVKMKHLRDGSVLTQTVKTSDTVEDAVVDSHRAQYQYDDGECFVFMDTRSFEQIFVSKGNVPGRERYLREGDEYDILIWNGESIDIKIPTKMVFRVAHSEPYLKGDTVSGATKPVTTETGLVVRVPLFIKQGEKILINTETNEYQERVND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83561</accession>
    <name>MNME_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">thdF</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">TP_0550</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71311">
        <property type="entry name" value="B71311"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881997.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83561"/>
    <dbReference type="SMR" id="O83561"/>
    <dbReference type="IntAct" id="O83561">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0550"/>
    <dbReference type="EnsemblBacteria" id="AAC65535">
        <property type="protein sequence ID" value="AAC65535"/>
        <property type="gene ID" value="TP_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0550"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_12"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000188941" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="223"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
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        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
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            <position position="128"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="252"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
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            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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        <location>
            <position position="258"/>
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            <name>Mg(2+)</name>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="495" mass="53781" checksum="C40681269E7AFD2F" modified="1998-11-01" version="1">MRAHEYALDDDIVAIATALSPAALGIVRTSGSSSIERVASFFSRAQALTRARAHTFLHGWILDGKTRVDEVVLLVYRAPHSFTGEHAVEIICHGGVRTVQAVYRLCLAQGFRAAQRGEFSFRSFFHGKRDLTRIEAIQSLVDARTCAAQQQAVLHLSGALQQEIAALTRALLAFSATLQGEIEYPEDEETRVHDIDMRELEPLVERLRRLRACWQERALQRTGVRIVLGGCPNAGKSSLFNALLGQDRAIVSSVPGTTRDWLEADLDLSGIPVRLCDTAGLRVTDNPIEAQGVVRSEQLLQGADCVFYIINGRAGVQAADCAFLSDCAVPLVVVVTHNDLMSMSERIQVCQAVQPFISAPVLSCARSQDARGAGEQCLAGGKNGEVRDRAPRAFVCVSAKTHAGLDALRAQTLHLLHGGQVPYEELSLGSERQYVLVDAAVQALEHAQEAYARGFGLDAVVHDLEEALYHCGALTGEVHSEDILDALFEKLCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83562</accession>
    <name>O83562_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="C71311"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
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    <dbReference type="STRING" id="243276.TPANIC_0551"/>
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    </dbReference>
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        <property type="gene ID" value="TPANIC_0551"/>
    </dbReference>
    <dbReference type="GeneID" id="57879076"/>
    <dbReference type="KEGG" id="tpa:TP_0551"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
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        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="53"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="362" mass="38679" checksum="94B49D218CD5EF41" modified="1998-11-01" version="1">MEEFIFWNLSVIHAVQQAAHPVITHAVVLFTFFGGKGIALCSLWVLWCVEYRKGLAIAYALACSEGLNYALKGLLRVPRPFVRDPSVKLVFHDGFSTPSGHAQASALFVLLARSYPSAKTPVPCFCAPGCGTDRQVGDRENPSSYGQERTPLARTAWTGVAGVLFVGVIGLSRVYLGVHYPIDVLLGWLNAVLFGALILGMRRALRRGVVFFTRIQEVSGRSFAGLRFSAVVCIALLLAVGGADVSMCGAFCGLGAGHLFIFDRWVTRRAPAGGVGFHAAGGSFTQKVVRFCVGCVFCSVVSSALHALFSGAPAEYARLLRFVRYGIGASLSTGVVPLLFLRVGLAGGLPFHAPAPTAVRER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83563</accession>
    <name>Y552_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0552</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0552</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="D71311"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83563"/>
    <dbReference type="IntAct" id="O83563">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0552"/>
    <dbReference type="EnsemblBacteria" id="AAC65538">
        <property type="protein sequence ID" value="AAC65538"/>
        <property type="gene ID" value="TP_0552"/>
    </dbReference>
    <dbReference type="GeneID" id="57879077"/>
    <dbReference type="KEGG" id="tpa:TP_0552"/>
    <dbReference type="eggNOG" id="ENOG50343GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748856_0_0_12"/>
    <dbReference type="OMA" id="VYEIYWM"/>
    <dbReference type="OrthoDB" id="1350653at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202273" description="Uncharacterized protein TP_0552">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <sequence length="177" mass="20172" checksum="59A0F0B815D006EE" modified="1998-11-01" version="1">MQSLEPLITKQLRPAPVGVPEGTPQQVLYVLTWSALTQVDKYRISTAVPAVSGVYELYYMDEARALNLLTAAHAWYGGLRGNVRAAVDPHETADPARRALLTDATLYYRYSVSHSRDDMCDLVWFLHTQYFPGSVRVQHSGRYSAIFVQERAPDRVYWLEDLPHRTERGSMQTRVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83569</accession>
    <name>O83569_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71310">
        <property type="entry name" value="B71310"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882005.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83569">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0558"/>
    <dbReference type="EnsemblBacteria" id="AAC26562">
        <property type="protein sequence ID" value="AAC26562"/>
        <property type="gene ID" value="TP_0558"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75745">
        <property type="protein sequence ID" value="AGN75745"/>
        <property type="gene ID" value="TPANIC_0558"/>
    </dbReference>
    <dbReference type="GeneID" id="57879084"/>
    <dbReference type="KEGG" id="tpa:TP_0558"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.555"/>
    <dbReference type="eggNOG" id="COG2215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058605_4_0_12"/>
    <dbReference type="OMA" id="CSGAIMI"/>
    <dbReference type="OrthoDB" id="1515392at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503410" description="Nickel/cobalt efflux system" evidence="8">
        <location>
            <begin position="26"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC26562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="302" mass="32206" checksum="940544A52C5D2EC5" modified="1998-11-01" version="1">MKKVGVRVRACILCALAACATGVLANPFFGGAPARPRRQRTPELLLRRYALVHQRLGAAIVQWSKTHSTRAWWITVMLSFAYGVLHALGPGHRKAALFSFYLGRNAPVWEPALTAALLAALHGAASLLLLSAFRGVSGAIGAHSARTMWYMEVGSYGLLTFLALFSLVHELMHLFPSGGRYFSCGCSAHTAVCMRTGTVAHMQWGTMLLSGLFICPAALFVMILVLSLDAVGLGVAAVLSISAGLALPLMAVGYLAWASRAGIFYRMQKNTRHAQAVLSVVSITSYGIMLIVCTSALVASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83572</accession>
    <name>O83572_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71310">
        <property type="entry name" value="E71310"/>
    </dbReference>
    <dbReference type="IntAct" id="O83572">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0561"/>
    <dbReference type="EnsemblBacteria" id="AAC26565">
        <property type="protein sequence ID" value="AAC26565"/>
        <property type="gene ID" value="TP_0561"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75748">
        <property type="protein sequence ID" value="AGN75748"/>
        <property type="gene ID" value="TPANIC_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0561"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.558"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_2_3_12"/>
    <dbReference type="OMA" id="RAWGIGQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC26565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="283" mass="29876" checksum="DA1CC2D7B9D7CE02" modified="1998-11-01" version="1">MLRTSVLVCIGCLSAAIPARLGARAVPPLSSAVVDEAALLSVQEARGIRALLEGLARPSGDGSSRSHPSPAPEAHARTLHDGTPLQIAVLIVDSLQGDSLEDFSLRVAQEWGIGSRAQDTGIVLVIARAERKARIEVGYGLEDRVTDVHAHQLIRGTLAPCFQAGAYAQGVYETVLRLATLVRGQHEVQQFMQPRSVQPAVPRRGPVRNSAGSVFFFLLLFYCLGGRLLPGGVLWPLLFFGTRRRYDPFGSGFSGAFGEWAGDGGGFSGGGGRFGGGGASGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83574</accession>
    <name>O83574_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71308">
        <property type="entry name" value="A71308"/>
    </dbReference>
    <dbReference type="IntAct" id="O83574">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0563"/>
    <dbReference type="EnsemblBacteria" id="AAC65546">
        <property type="protein sequence ID" value="AAC65546"/>
        <property type="gene ID" value="TP_0563"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75750">
        <property type="protein sequence ID" value="AGN75750"/>
        <property type="gene ID" value="TPANIC_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0563"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.560"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1824500_0_0_12"/>
    <dbReference type="OMA" id="EANMIIR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15724" checksum="AF8121BC67B76F2E" modified="1998-11-01" version="1">MSMTSFYERIGAILRDRLNSDEDPFDQWDNRGGKYRTCAGRMERRPPPKKNPPPGPVRVPVPPELVEDFAVLSVPAGLPLSYCKQSWKRLLKKYHPDVFTCTHTSEQAADIVRRINSSYKRIETWFETGALPTDNKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83578</accession>
    <name>ALKH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative KHG/KDPG aldolase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>4-hydroxy-2-oxoglutarate aldolase</fullName>
                <ecNumber>4.1.3.16</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>2-keto-4-hydroxyglutarate aldolase</fullName>
                <shortName>KHG-aldolase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
                <ecNumber>4.1.2.14</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>2-keto-3-deoxy-6-phosphogluconate aldolase</fullName>
                <shortName>KDPG-aldolase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName>Phospho-2-dehydro-3-deoxygluconate aldolase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName>Phospho-2-keto-3-deoxygluconate aldolase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">eda</name>
        <name type="ordered locus">TP_0568</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:35639"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:71685"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:30687"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:62213"/>
            <dbReference type="EC" id="4.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate acid metabolism; 2-dehydro-3-deoxy-D-gluconate degradation; D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-gluconate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate metabolism; glyoxylate and dicarboxylate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.16"/>
    <dbReference type="EC" id="4.1.2.14"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71308">
        <property type="entry name" value="F71308"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882015.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83578"/>
    <dbReference type="SMR" id="O83578"/>
    <dbReference type="STRING" id="243276.TPANIC_0568"/>
    <dbReference type="EnsemblBacteria" id="AAC65542">
        <property type="protein sequence ID" value="AAC65542"/>
        <property type="gene ID" value="TP_0568"/>
    </dbReference>
    <dbReference type="GeneID" id="57879092"/>
    <dbReference type="KEGG" id="tpa:TP_0568"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_1_1_12"/>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="OrthoDB" id="1175355at2"/>
    <dbReference type="UniPathway" id="UPA00227"/>
    <dbReference type="UniPathway" id="UPA00856">
        <property type="reaction ID" value="UER00829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106009">
        <property type="term" value="F:(4S)-4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000201043" description="Putative KHG/KDPG aldolase">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with KHG or pyruvate" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="210" mass="22074" checksum="7DC3408B01C244E7" modified="1998-11-01" version="1">MITIFEALERVRVIPVVTLERVEDAVPLARALITGGIRCMEVTFRTLVAAEAIAAIRQECADVLLGAGTVLTVEQAQQAQAAGAQFVVSPGFNPRVVAHCLGHGVPIIPGIASATEIERALEFGISVVKFFPAELLGGTAMMSALARPYTAVRFVPTGGIHLNNLAEYVAHPRVLACGGSWMVPAQSIAAGDFSQVTALSQQTLQIVGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83581</accession>
    <name>O83581_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tp70 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71309">
        <property type="entry name" value="A71309"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882018.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83581">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0571"/>
    <dbReference type="EnsemblBacteria" id="AAC65544">
        <property type="protein sequence ID" value="AAC65544"/>
        <property type="gene ID" value="TP_0571"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75758">
        <property type="protein sequence ID" value="AGN75758"/>
        <property type="gene ID" value="TPANIC_0571"/>
    </dbReference>
    <dbReference type="GeneID" id="57879095"/>
    <dbReference type="KEGG" id="tpa:TP_0571"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.567"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_1_12"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="221" mass="24314" checksum="67FD6612F40FFA26" modified="1998-11-01" version="1">MGCACLSSFCWARAGVGVSVSKGLRGTLIGVGVSLAFLLVVYRLFAGSYNRMISLDEAVKSAWSQVEAVLQRRLDLIPNLVSTVKGYAEHESDTLKRVAEARSRAGGVMQVGESALSDPEKFARFQRVQAEIGGALGRLLLVSEQYPALRANESFLALQSQLEGTENRISVERTRYNRAVQEYNAYIRSFPRSAVARWGNFSSRPYFTAHEGAVAAPRVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83594</accession>
    <name>O83594_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligopeptide ABC transporter, periplasmic binding protein (OppA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71307">
        <property type="entry name" value="G71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882031.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0585"/>
    <dbReference type="EnsemblBacteria" id="AAC65557">
        <property type="protein sequence ID" value="AAC65557"/>
        <property type="gene ID" value="TP_0585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75770">
        <property type="protein sequence ID" value="AGN75770"/>
        <property type="gene ID" value="TPANIC_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0585"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.580"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_12"/>
    <dbReference type="OMA" id="YDFFTWE"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="85"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="547" mass="61378" checksum="82FFC723A01396ED" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>O83606</accession>
    <name>Y597_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0597</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0597</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71303">
        <property type="entry name" value="G71303"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83606"/>
    <dbReference type="SMR" id="O83606"/>
    <dbReference type="IntAct" id="O83606">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65580">
        <property type="protein sequence ID" value="AAC65580"/>
        <property type="gene ID" value="TP_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0597"/>
    <dbReference type="HOGENOM" id="CLU_2412295_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202283" description="Uncharacterized protein TP_0597">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <sequence length="92" mass="10313" checksum="A2DE98A2A8461FF2" modified="1998-11-01" version="1">MRRILSYKDEDIDAHMVMRRSLLVTNLGKGALVGHRVQQSQVYRMSRAYALPKVAAITSNGVVSVNYDGSVSWYEGDGATLKATEFIRTEDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83608</accession>
    <name>Y599_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0599</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0599</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71304">
        <property type="entry name" value="A71304"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83608"/>
    <dbReference type="STRING" id="243276.TPANIC_0599"/>
    <dbReference type="PRIDE" id="O83608"/>
    <dbReference type="EnsemblBacteria" id="AAC65582">
        <property type="protein sequence ID" value="AAC65582"/>
        <property type="gene ID" value="TP_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0599"/>
    <dbReference type="eggNOG" id="ENOG5031C85">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282737_0_0_12"/>
    <dbReference type="OMA" id="DANTEYI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025682">
        <property type="entry name" value="CpXC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14353">
        <property type="entry name" value="CpXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202285" description="Uncharacterized protein TP_0599">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <sequence length="218" mass="24978" checksum="A06463E604F1C1F7" modified="1998-11-01" version="1">MMQLRCACERVFDIEHETVISLDEHPEFVARIQQGDFLSYQCPACGARIRAEIKTEFVWHAKNVHLLLVPERERLRCLAFCAGMHMSDGDSADFCEPFVLREHQTPVIGYAELADRVAILAWDLNPEIVEAVKFFVLEGAPHLGDKRVSCFFERCVGDTGSRVMELHVYGIREQQTAIMPVPMNVYERVERERGKQAELFEALYVGAYLSYKNVFTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83619</accession>
    <name>O83619_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein H (TprH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71302">
        <property type="entry name" value="G71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882056.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83619">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0610"/>
    <dbReference type="EnsemblBacteria" id="AAC65586">
        <property type="protein sequence ID" value="AAC65586"/>
        <property type="gene ID" value="TP_0610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75791">
        <property type="protein sequence ID" value="AGN75791"/>
        <property type="gene ID" value="TPANIC_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0610"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.650"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="LVRERCV"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="181"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="490"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="693" mass="76111" checksum="16A0105A489D8E39" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83633</accession>
    <name>Y625_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0625</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0625</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71302">
        <property type="entry name" value="B71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882071.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83633"/>
    <dbReference type="SMR" id="O83633"/>
    <dbReference type="IntAct" id="O83633">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0625"/>
    <dbReference type="EnsemblBacteria" id="AAC65604">
        <property type="protein sequence ID" value="AAC65604"/>
        <property type="gene ID" value="TP_0625"/>
    </dbReference>
    <dbReference type="GeneID" id="57879148"/>
    <dbReference type="KEGG" id="tpa:TP_0625"/>
    <dbReference type="eggNOG" id="ENOG5032BIC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299267_0_0_12"/>
    <dbReference type="OMA" id="QEEHTTR"/>
    <dbReference type="OrthoDB" id="1583771at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202291" description="Uncharacterized protein TP_0625">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="250" mass="28874" checksum="107002FE47B25186" modified="1998-11-01" version="1">MHVPRSILRAGYFSQVKRTCDDVPMAFCSQAQLKGRSTMIKPRAYALLGVFFLYACASTPREEDVPEKFTPADLMLRAQESYDAGNITWARFYYQTVLDRFPNNESAVISAEFELAHILVKQKSWQDAYNRLMYILKKYEAAGSARLPPAYYKLTLIDLSRVKPHLNLETANTKATEYQKNYQEELKQRQELRQKLLQERTQKMLEALHQEETPEQDARDTAKKKTDQEEHTMRKANAPKTKASGEAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83652</accession>
    <name>O83652_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71299">
        <property type="entry name" value="E71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882091.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0646"/>
    <dbReference type="EnsemblBacteria" id="AAC65619">
        <property type="protein sequence ID" value="AAC65619"/>
        <property type="gene ID" value="TP_0646"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75826">
        <property type="protein sequence ID" value="AGN75826"/>
        <property type="gene ID" value="TPANIC_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0646"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.639"/>
    <dbReference type="eggNOG" id="ENOG503464J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684929_0_0_12"/>
    <dbReference type="OMA" id="LIWKLDN"/>
    <dbReference type="OrthoDB" id="773354at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="440" mass="49329" checksum="631D599CED7BCF7F" modified="1998-11-01" version="1">MGRMRKVACAFRKLWCRFVVLSISILVSCSVVTRHPLRLGFFTFFLLGSFLVLVSSCTRWMGRELHGQRLFALTYGDAENQLHFPDAGYAQSQSNIQLCMKDGIFYVAHAATGKVMRMTSFGDVLAVIFNPEKNAMTPQFSEGLQSAAITTRRAVPYPLHAPTFLAVDSQNTLYVVDAVLPEHVQHDPEENLALVNTILLFDEEGRFMHAIGQQGIGGTPFPAIEGVYVNSADELVVVCRSVDAMRVYWFNAQRVPIHQRALPFSPLPTSFAAQEKGYAFVERVLPDVSERRLIAKVDYYTAVHDPATGANSSVRYAKSSVYFISLETGVYEWKVDLPAHEVSGTENQERGPYKKAFSLLGVSAQQGILCVSPDRFGYAALLLDLRSFTIRQRSIHMRSDTLVYNVFHFSPTGILSSVLATDTEAVVMWWRFDRILSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83657</accession>
    <name>O83657_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71300">
        <property type="entry name" value="B71300"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882096.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83657">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65624">
        <property type="protein sequence ID" value="AAC65624"/>
        <property type="gene ID" value="TP_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0651"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.693"/>
    <dbReference type="HOGENOM" id="CLU_015767_1_2_12"/>
    <dbReference type="OMA" id="QGTYNHS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="581"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="803" mass="88246" checksum="79F01FA9F42BEC7A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83667</accession>
    <name>Y661_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0661</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0661</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71297">
        <property type="entry name" value="F71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882106.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83667"/>
    <dbReference type="SMR" id="O83667"/>
    <dbReference type="IntAct" id="O83667">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0661"/>
    <dbReference type="EnsemblBacteria" id="AAC65640">
        <property type="protein sequence ID" value="AAC65640"/>
        <property type="gene ID" value="TP_0661"/>
    </dbReference>
    <dbReference type="GeneID" id="57879184"/>
    <dbReference type="KEGG" id="tpa:TP_0661"/>
    <dbReference type="eggNOG" id="ENOG5031C4H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131004_0_0_12"/>
    <dbReference type="OMA" id="YECIALL"/>
    <dbReference type="OrthoDB" id="1417608at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202296" description="Uncharacterized protein TP_0661">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <sequence length="170" mass="19236" checksum="8F143334219E0569" modified="1998-11-01" version="1">MDRERALHRAGQVEAILVAQIELVGQVIQVQRSVYESLRTRAWEHVESFVSRAQALSREFLHLDKRCFLLLQEVRPYGDAPVDFDSFFAYLRRADVNVHDAVVALYRTLRSKVASSKNEHDAIQHYLTHARGLAHALVSALTCEQQGSSYTKDGCPVRCAPGSLVFDRVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83668</accession>
    <name>ALF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Fructose-bisphosphate aldolase</fullName>
            <shortName>FBP aldolase</shortName>
            <shortName>FBPA</shortName>
            <ecNumber>4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fructose-1,6-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">fba</name>
        <name type="synonym">fda</name>
        <name type="ordered locus">TP_0662</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71297">
        <property type="entry name" value="G71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882107.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83668"/>
    <dbReference type="SMR" id="O83668"/>
    <dbReference type="IntAct" id="O83668">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0662"/>
    <dbReference type="PRIDE" id="O83668"/>
    <dbReference type="EnsemblBacteria" id="AAC65635">
        <property type="protein sequence ID" value="AAC65635"/>
        <property type="gene ID" value="TP_0662"/>
    </dbReference>
    <dbReference type="GeneID" id="57879185"/>
    <dbReference type="KEGG" id="tpa:TP_0662"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_0_12"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000178753" description="Fructose-bisphosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="332" mass="36189" checksum="B6D8D56BF99B52EA" modified="1998-11-01" version="1">MTSYKALGLVNTKDLFAKAVKGGYAIPAYNFNNLEQLQAIIQACVETRSPVILQVSSGARKYANATLLRNMARGAVEYAHELGVDIPIVLHLDHGDSLELCIDCIESGFSSVMIDGSALPYDENVALSRKVCEYAHARADYVTVEGELGVLAGVEDDVVAEKSHYTMPDEVEDFVKKTGVDSLAISIGTSHGRAKFTPEQCTRNADGVLIPPPLRFDILAEIEKRIPGFPIVLHGASSVPVEYVREVERYGGNLPDSVGIPEEQLRKAAKSAVCKVNIDSDGRLAMTAAIRRVLTTKVDEFDPRKYLGPARDELKKLYMHKNKEVLGSAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83693</accession>
    <name>O83693_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71293">
        <property type="entry name" value="D71293"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882140.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83693">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0695"/>
    <dbReference type="EnsemblBacteria" id="AAC65662">
        <property type="protein sequence ID" value="AAC65662"/>
        <property type="gene ID" value="TP_0695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75873">
        <property type="protein sequence ID" value="AGN75873"/>
        <property type="gene ID" value="TPANIC_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0695"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.687"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_5_0_12"/>
    <dbReference type="OMA" id="GYMSGWT"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="110"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="597" mass="63326" checksum="7B775117C9BFD6A6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83696</accession>
    <name>Y698_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0698</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0698</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71293">
        <property type="entry name" value="G71293"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882143.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83696"/>
    <dbReference type="IntAct" id="O83696">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65667">
        <property type="protein sequence ID" value="AAC65667"/>
        <property type="gene ID" value="TP_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0698"/>
    <dbReference type="HOGENOM" id="CLU_1488386_0_0_12"/>
    <dbReference type="OMA" id="TSSAWYS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014255" description="Uncharacterized protein TP_0698">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="181" mass="18894" checksum="51E524D22D49C2B9" modified="1998-11-01" version="1" precursor="true">MRRLLACSAGVLCFSQLGALELFLSPKIGITSVYQFGSNGGSDGTSSGKGVSFDRLIGRVDLGLILVNGLTISASAESSLTNVFVRAQALIGYAVRVGGLRAIVSSGVNICGDSCATSEGKSSAWYSKLLYSVPLNLEVQYYLTSFAGVAVAASTAVGVRDFNFKEFTLPLSLTIGPTFRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-10-03" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83720</accession>
    <name>IOJAP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rsfS</name>
        <name type="ordered locus">TP_0738</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002815" last="E1002815">
            <title>RsfA (YbeB) proteins are conserved ribosomal silencing factors.</title>
            <authorList>
                <person name="Hauser R."/>
                <person name="Pech M."/>
                <person name="Kijek J."/>
                <person name="Yamamoto H."/>
                <person name="Titz B."/>
                <person name="Naeve F."/>
                <person name="Tovchigrechko A."/>
                <person name="Yamamoto K."/>
                <person name="Szaflarski W."/>
                <person name="Takeuchi N."/>
                <person name="Stellberger T."/>
                <person name="Diefenbacher M.E."/>
                <person name="Nierhaus K.H."/>
                <person name="Uetz P."/>
            </authorList>
            <dbReference type="PubMed" id="22829778"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002815"/>
        </citation>
        <scope>INTERACTION WITH RPLN</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71288">
        <property type="entry name" value="G71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882183.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83720"/>
    <dbReference type="SMR" id="O83720"/>
    <dbReference type="IntAct" id="O83720">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0738"/>
    <dbReference type="EnsemblBacteria" id="AAC65706">
        <property type="protein sequence ID" value="AAC65706"/>
        <property type="gene ID" value="TP_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0738"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_5_0_12"/>
    <dbReference type="OMA" id="HLMSEKS"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000419627" description="Ribosomal silencing factor RsfS">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22829778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="111" mass="12276" checksum="3BD58850899495C3" modified="1998-11-01" version="1">MSANGAASAVAEALCDARAEDVCVFDVSARCGWADFAVVATVPGLLHGTHRLVCEQAARFGLREVHRKKRGLCEEQWRVLDFGSILVHLMSAQARAFYDLDRLWQDCLVAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83738</accession>
    <name>DEF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Peptide deformylase</fullName>
            <shortName>PDF</shortName>
            <ecNumber>3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">def</name>
        <name type="ordered locus">TP_0757</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71284">
        <property type="entry name" value="H71284"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882202.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83738"/>
    <dbReference type="SMR" id="O83738"/>
    <dbReference type="IntAct" id="O83738">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0757"/>
    <dbReference type="EnsemblBacteria" id="AAC65724">
        <property type="protein sequence ID" value="AAC65724"/>
        <property type="gene ID" value="TP_0757"/>
    </dbReference>
    <dbReference type="GeneID" id="57879280"/>
    <dbReference type="KEGG" id="tpa:TP_0757"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_0_12"/>
    <dbReference type="OMA" id="ILYPMRI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000082869" description="Peptide deformylase">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="162" mass="18323" checksum="15AEA6C940819CC1" modified="1998-11-01" version="1">MELKFLGEPCLTTVSEPVSEVDEQLRAFISGMFRVMRGAGGVGLAAPQVGRTVRVFVVDVEHHVRAFINPQITAASEEQSSYEEGCLSIPHIYERVLRPRRVSVQYLDENGKRCAVDADGILARVIQHEYDHLDGILFLDRIDEKRRDDALRRYAALRGTIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83744</accession>
    <name>Y763_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0763</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0763</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71285">
        <property type="entry name" value="F71285"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83744"/>
    <dbReference type="SMR" id="O83744"/>
    <dbReference type="IntAct" id="O83744">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65734">
        <property type="protein sequence ID" value="AAC65734"/>
        <property type="gene ID" value="TP_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0763"/>
    <dbReference type="eggNOG" id="ENOG5033YSU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086052_0_0_12"/>
    <dbReference type="OMA" id="CNEYEEA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202318" description="Uncharacterized protein TP_0763">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="313" mass="36156" checksum="9B5FC058146E0C58" modified="1998-11-01" version="1">MGFLGYIYNCIRIHVSLAPIVEWRPAQAGRQYRRFPMKIKALVVLFNGALLLLCMGTGYVLFLTPVRGTGWQSVRAYGIFFLIFLLLFLLINTLYVKNRRLLRYLDAEDWSALAALLEEEVFTRNRVALRRVSLLSESLILLSDFEALERLEHFVHAQRPRYIMKCALTFAVGKLLAGKYSELRTFMTRVAATQAPVQPWTRFYLAFACHLCGDFEQAHAHLLTLVHTKRQPLIRVLSAYLLSEVLPEKLRRAPAHDAQLIARGCAHAAQVRADVHAHYTPRRWADYENRKKQNVDVLVFLKLMQDARAWLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83758</accession>
    <name>O83758_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA protein (DedA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71282">
        <property type="entry name" value="D71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882224.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83758">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0779"/>
    <dbReference type="EnsemblBacteria" id="AAC65747">
        <property type="protein sequence ID" value="AAC65747"/>
        <property type="gene ID" value="TP_0779"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75952">
        <property type="protein sequence ID" value="AGN75952"/>
        <property type="gene ID" value="TPANIC_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="57879301"/>
    <dbReference type="KEGG" id="tpa:TP_0779"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.766"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_4_1_12"/>
    <dbReference type="OMA" id="MHIILEF"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="214" mass="23453" checksum="F5BCF4751B3C7AD9" modified="1998-11-01" version="1">MVHTLFSWVSAHIHSLPMVVFVSLLLAGVHVPVSEDALIVMSALVCRQDGASVPSFLGALYAGALISDYAVYFWGYLLQQGALRVAALERTLASCRAQKIVTLLSRYGLWVYVLARFVPFGVRNVVSLTSGFVRVPFVRFACYDALAAACSISVLFWMTYFLGSVQRISLKVFAVVILPLSVLGIRVLIGRRQKTTGDGVRITHDDVQTNVGVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83772</accession>
    <name>METK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">TP_0794</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71281">
        <property type="entry name" value="A71281"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882239.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83772"/>
    <dbReference type="SMR" id="O83772"/>
    <dbReference type="IntAct" id="O83772">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0794"/>
    <dbReference type="EnsemblBacteria" id="AAC65758">
        <property type="protein sequence ID" value="AAC65758"/>
        <property type="gene ID" value="TP_0794"/>
    </dbReference>
    <dbReference type="GeneID" id="57879315"/>
    <dbReference type="KEGG" id="tpa:TP_0794"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_12"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000174617" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <sequence length="396" mass="42991" checksum="E532DD39B0BBE711" modified="1998-11-01" version="1">METFFTSESVSEGHPDKLCDQISDAVLDACLSQDPHSCVACETFASTSLILIGGEISTRAHINLTQIARDVAADIGYVSADVGLDAASMAVLDMTHHQSPDIAQGVHGAGLKEFAGSQGAGDQGIMFGFACRETPEFMPAPLMCAHAVVRYAATLRHERRVPWLRPDAKSQVTVQYEGHRPVRISAVVFSQQHDPSPSYETIRETLIEEIVRPALAPTGLLDENTRFFINPTGRFVIGGPFGDTGLTGRKIIVDTYGGMGRHGGGSFSGKDASKVDRSAAYMARYIAKNIVAADLAERCEVQLAYAIGVPYPVSLRIETFGTARASESHITHAVKEIFDLTPAGIVRTLDLCAPRYRSTAVYGHFGREQFPWERTDCVCDLQRAVRPFALSGQIKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O83776</accession>
    <name>SYM_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="synonym">metS</name>
        <name type="ordered locus">TP_0798</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71281">
        <property type="entry name" value="E71281"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882243.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83776"/>
    <dbReference type="SMR" id="O83776"/>
    <dbReference type="IntAct" id="O83776">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0798"/>
    <dbReference type="PRIDE" id="O83776"/>
    <dbReference type="EnsemblBacteria" id="AAC65761">
        <property type="protein sequence ID" value="AAC65761"/>
        <property type="gene ID" value="TP_0798"/>
    </dbReference>
    <dbReference type="GeneID" id="57879318"/>
    <dbReference type="KEGG" id="tpa:TP_0798"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
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        <property type="entry name" value="MetRS_Zn"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
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        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
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        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
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    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF50249"/>
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        <property type="entry name" value="SSF57770"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
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    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000139168" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="648"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="344"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="811" mass="90417" checksum="F0D0FAA08724316E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="147" xmlns="http://uniprot.org/uniprot">
    <accession>O83782</accession>
    <name>O83782_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter, ATP-binding protein (UgpC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="F71279"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75976">
        <property type="protein sequence ID" value="AGN75976"/>
        <property type="gene ID" value="TPANIC_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0804"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.790"/>
    <dbReference type="eggNOG" id="COG3842">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_12"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50331"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="387" mass="42647" checksum="C38DB77EB723E21D" modified="1998-11-01" version="1">MAKVELKHICKTYHGCVHAVKDVTITAESGEFVVFIGPSGCGKSTALRIIAGLEDICSGDLYIDGEHMNHVTPKDRNIAMVFQNYALYPHMNVFDNMAFGLRIRKIPQQEIIRRVHEAARVLDIEPLLARKPKALSGGQRQRVAVGRAIVRNPKVFLFDEPLSNLDAKLRVQMRSEISLLHKRLKATMIYVTHDQMEAMTMADKIVIMKDGCVQQIGSPLHIYQHPANTFVAQFIGSPPMNCFPVTIVKDEHGIKIDAGLFVLRPDIPASFLLKNYIGTQVVFGLRPEAITPRTEETLARECANVIQLKVLAVEALGAETFVYLDAGVQPIVARCNHTLTAHEGTLLTLALDLSKALYFDAETGHALQGGTSQVATVHAPPEISTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83795</accession>
    <name>O83795_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desulfoferrodoxin (Rbo)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2006" name="J. Biol. Inorg. Chem." volume="11" first="548" last="558">
            <title>The first crystal structure of class III superoxide reductase from Treponema pallidum.</title>
            <authorList>
                <person name="Santos-Silva T."/>
                <person name="Trincao J."/>
                <person name="Carvalho A.L."/>
                <person name="Bonifacio C."/>
                <person name="Auchere F."/>
                <person name="Raleiras P."/>
                <person name="Moura I."/>
                <person name="Moura J.J."/>
                <person name="Romao M.J."/>
            </authorList>
            <dbReference type="PubMed" id="16791639"/>
            <dbReference type="DOI" id="10.1007/s00775-006-0104-y"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH IRON</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71276">
        <property type="entry name" value="A71276"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882267.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.55 A"/>
        <property type="chains" value="A/B/C/D=1-128"/>
    </dbReference>
    <dbReference type="PDBsum" id="1Y07"/>
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        <property type="protein sequence ID" value="AAC65791"/>
        <property type="gene ID" value="TP_0823"/>
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    <dbReference type="EnsemblBacteria" id="AGN75993">
        <property type="protein sequence ID" value="AGN75993"/>
        <property type="gene ID" value="TPANIC_0823"/>
    </dbReference>
    <dbReference type="GeneID" id="57879340"/>
    <dbReference type="KEGG" id="tpa:TP_0823"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.809"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="EEKHYIQ"/>
    <dbReference type="OrthoDB" id="1496450at2"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
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        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
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    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
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            <position position="50"/>
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        <ligand>
            <name>Iron</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Iron</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
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        <location>
            <position position="76"/>
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        <ligand>
            <name>Iron</name>
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            <name>Iron</name>
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    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Iron</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65791.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="1Y07"/>
        </source>
    </evidence>
    <sequence length="128" mass="13802" checksum="C9401553A5FA0ABE" modified="1998-11-01" version="1">MGRELSFFLQKESAGFFLGMDAPAGSSVACGSEVLRAVPVGTVDAAKEKHIPVVEVHGHEVKVKVGSVAHPMTPEHYIAWVCLKTRKGIQLKELPVDGAPEVTFALTADDQVLEAYEFCNLHGVWSGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83796</accession>
    <name>DXS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="1">DXP synthase</shortName>
            <shortName evidence="1">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs</name>
        <name type="ordered locus">TP_0824</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71276">
        <property type="entry name" value="B71276"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882268.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83796"/>
    <dbReference type="SMR" id="O83796"/>
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        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0824"/>
    <dbReference type="EnsemblBacteria" id="AAC65792">
        <property type="protein sequence ID" value="AAC65792"/>
        <property type="gene ID" value="TP_0824"/>
    </dbReference>
    <dbReference type="GeneID" id="57879341"/>
    <dbReference type="KEGG" id="tpa:TP_0824"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_12"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189166" description="1-deoxy-D-xylulose-5-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="630" mass="68103" checksum="70F4E3340E682448" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83799</accession>
    <name>O83799_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71276">
        <property type="entry name" value="E71276"/>
    </dbReference>
    <dbReference type="IntAct" id="O83799">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0827"/>
    <dbReference type="EnsemblBacteria" id="AAC65800">
        <property type="protein sequence ID" value="AAC65800"/>
        <property type="gene ID" value="TP_0827"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75997">
        <property type="protein sequence ID" value="AGN75997"/>
        <property type="gene ID" value="TPANIC_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0827"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.814"/>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053150_0_0_12"/>
    <dbReference type="OMA" id="TEFSAYI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="425" mass="47226" checksum="15EE481B638DB556" modified="1998-11-01" version="1">MATIPPCTMEQSLCAMGSLSLQAPFCRFLNSTILGKRSAHVIVPRLVWLKKQMPLPWSCQKKRARSALPTIQSCTTIFRTRTYWRSSNSYSKLPLGLDTLKGHWIMVAARCLDRIAHNWAAKASSILLAFLLVQFYSGSLLERRAISVPLVVRNEGALTPALRFPQKVTVLMRASRDTLGALRGSDIVPYVDLSSYTEEGEYAVPVRVTVADHVAPPDALELVADPAIIPFKLERSVTKNIPITLSLEGVPAYGYELREVDTNPSMVEIRGPASLLVSYTQAVTETLDITNRRASFSGVIGLINPSTLVSFPKTKTQFVVRVREVSELKELETTHVSFTDCAPHLTFSIEPVTIRAQVQVPKHVIEEMHPEEFFSVSAREITEPGRVTAPLILSLPEHVRMVQYSPKEVHVHVREAQSVPADGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83804</accession>
    <name>O83804_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71277">
        <property type="entry name" value="B71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882276.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83804">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0832"/>
    <dbReference type="EnsemblBacteria" id="AAC65801">
        <property type="protein sequence ID" value="AAC65801"/>
        <property type="gene ID" value="TP_0832"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76002">
        <property type="protein sequence ID" value="AGN76002"/>
        <property type="gene ID" value="TPANIC_0832"/>
    </dbReference>
    <dbReference type="GeneID" id="57879349"/>
    <dbReference type="KEGG" id="tpa:TP_0832"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.819"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078248_0_0_12"/>
    <dbReference type="OMA" id="EGIWIGS"/>
    <dbReference type="OrthoDB" id="1762425at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016862">
        <property type="entry name" value="UCP027936"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027936">
        <property type="entry name" value="UCP027936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="271" mass="29157" checksum="3A4A55649B98C446" modified="1998-11-01" version="1">MCSMSWKSFIIPVRWRCMAGKGKHSSAGLLFWLAFSLLMAVLFFLNRRNIDRVFSSAAVQGMFGNQDSMRVFDSARRSQAGSAVESDAKATLPTQDVAQPDAPVAGSPAPADAGTEGKDVGTVSGAPGSAQQSRAITLCWVRIDADGKITREEVARTLPHSTVPLSDALRALFLGPSEAEAVRGLRTLIPEGTRLRSARVQEGVAVLDLSEEFQFNQYGIEGYLAQLSQVVFTAAAFPTVHAVQFLIEGRRTEYLGSEGVWIGAPVSKSSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83818</accession>
    <name>Y846_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0846</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0846</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71273">
        <property type="entry name" value="F71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882290.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83818"/>
    <dbReference type="SMR" id="O83818"/>
    <dbReference type="IntAct" id="O83818">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0846"/>
    <dbReference type="EnsemblBacteria" id="AAC65819">
        <property type="protein sequence ID" value="AAC65819"/>
        <property type="gene ID" value="TP_0846"/>
    </dbReference>
    <dbReference type="GeneID" id="57879363"/>
    <dbReference type="KEGG" id="tpa:TP_0846"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116623_5_0_12"/>
    <dbReference type="OMA" id="DQSPQHM"/>
    <dbReference type="OrthoDB" id="2053327at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202337" description="Uncharacterized protein TP_0846">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <sequence length="108" mass="12146" checksum="FD05B2E3764046E8" modified="1998-11-01" version="1">MVSVKGQLHIDLLGASFSIQADEDSSYLRVLYEHYKMVVLQVEKTSGVRDPLKVAVIAGVLLADELHKEKRRRLVQSEEDLLEIGESTERMLESISKVVDEGFVCGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83825</accession>
    <name>O83825_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein (YlxH-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71274">
        <property type="entry name" value="E71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882297.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83825">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0853"/>
    <dbReference type="EnsemblBacteria" id="AAC65818">
        <property type="protein sequence ID" value="AAC65818"/>
        <property type="gene ID" value="TP_0853"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76023">
        <property type="protein sequence ID" value="AGN76023"/>
        <property type="gene ID" value="TPANIC_0853"/>
    </dbReference>
    <dbReference type="GeneID" id="57879370"/>
    <dbReference type="KEGG" id="tpa:TP_0853"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.840"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_2_12"/>
    <dbReference type="OMA" id="GANLHTC"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="378" mass="41238" checksum="45767D9F33D94AF8" modified="1998-11-01" version="1">MQIIPIASGKGGVGKSLLAANLSIALGQAGKKVVVADLDLGASNLHLALGQKGNKHGVGTFLMGASSFEEIMVPTGYPNVYLVPGDSEIPGFAALKVSQRRALTVGLLKTHADYVVLDLGAGTHLGVLEFFLLSSRGIIVTEPAVSAVLNAYLFLKNVVFKMLCAAFKKGTGGSIFLENLKSDAAAVQRMYVPKILAELERVDQRGVAVLLDRMRSFRPRLVMNMIADPKDVDKALKIRRSCEQYLNITLEYLGVIYQDTQQNVALSSGLPIVVYKPQSLIAQAVYRIADKILQSEGEEASSIEDYEGLVERSFASAEAEAEVDFQFRMDYLEDLIKSKTVCVGDLAEIIKAQQYEIATLRKQNLLLQRKINKTLRNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83829</accession>
    <name>Y857_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0857</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0857</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71272">
        <property type="entry name" value="A71272"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83829"/>
    <dbReference type="EnsemblBacteria" id="AAC65830">
        <property type="protein sequence ID" value="AAC65830"/>
        <property type="gene ID" value="TP_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0857"/>
    <dbReference type="HOGENOM" id="CLU_2222068_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202340" description="Uncharacterized protein TP_0857">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="106" mass="11607" checksum="0AFFB53157A4D369" modified="1998-11-01" version="1">MASGAPPLTQKTPSHARRKERRRPWAAAFGNHAALAPRALLASEQDRGTERHVVRRALLLIACGVVAVRRTHLEARDAYFGAHACAHLSICVHGDSRKQGEEANRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83833</accession>
    <name>GLMS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="1">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmS</name>
        <name type="ordered locus">TP_0861</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71272">
        <property type="entry name" value="E71272"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882305.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83833"/>
    <dbReference type="SMR" id="O83833"/>
    <dbReference type="STRING" id="243276.TPANIC_0861"/>
    <dbReference type="EnsemblBacteria" id="AAC65824">
        <property type="protein sequence ID" value="AAC65824"/>
        <property type="gene ID" value="TP_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0861"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_12"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000135405" description="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]">
        <location>
            <begin position="2"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 1" evidence="1">
        <location>
            <begin position="299"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="SIS 2" evidence="1">
        <location>
            <begin position="472"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="1">
        <location>
            <position position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <sequence length="635" mass="69181" checksum="DB84874078DE6AF3" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-09-26" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83842</accession>
    <name>FLID_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar hook-associated protein 2</fullName>
            <shortName>HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Filament cap protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">fliD</name>
        <name type="ordered locus">TP_0872</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Periplasmic flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71270">
        <property type="entry name" value="F71270"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882315.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83842"/>
    <dbReference type="SMR" id="O83842"/>
    <dbReference type="IntAct" id="O83842">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0872"/>
    <dbReference type="EnsemblBacteria" id="AAC65836">
        <property type="protein sequence ID" value="AAC65836"/>
        <property type="gene ID" value="TP_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0872"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028399_0_0_12"/>
    <dbReference type="OMA" id="FIGAYNE"/>
    <dbReference type="OrthoDB" id="883503at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177027" description="Flagellar hook-associated protein 2">
        <location>
            <begin position="1"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="660"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="722" mass="78400" checksum="E2AEEAD06348B0BC" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83856</accession>
    <name>PNP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">TP_0886</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71269">
        <property type="entry name" value="C71269"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882329.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83856"/>
    <dbReference type="SMR" id="O83856"/>
    <dbReference type="STRING" id="243276.TPANIC_0886"/>
    <dbReference type="EnsemblBacteria" id="AAC26576">
        <property type="protein sequence ID" value="AAC26576"/>
        <property type="gene ID" value="TP_0886"/>
    </dbReference>
    <dbReference type="GeneID" id="57879400"/>
    <dbReference type="KEGG" id="tpa:TP_0886"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_12"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329921" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="551"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="620"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <sequence length="702" mass="76332" checksum="BBE97F7E822B2960" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83861</accession>
    <name>IF2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">infB</name>
        <name type="ordered locus">TP_0891</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71269">
        <property type="entry name" value="H71269"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83861"/>
    <dbReference type="SMR" id="O83861"/>
    <dbReference type="IntAct" id="O83861">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0891"/>
    <dbReference type="EnsemblBacteria" id="AAC26581">
        <property type="protein sequence ID" value="AAC26581"/>
        <property type="gene ID" value="TP_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0891"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_12"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137275" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="328"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="337"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="362"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="437"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="473"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="337"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="437"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="842" mass="90925" checksum="C87934788AE3C94A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83869</accession>
    <name>O83869_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71266">
        <property type="entry name" value="H71266"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65867">
        <property type="protein sequence ID" value="AAC65867"/>
        <property type="gene ID" value="TP_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0899"/>
    <dbReference type="HOGENOM" id="CLU_1395772_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="195" mass="22122" checksum="085A6967F5837EC9" modified="1998-11-01" version="1">MGVARGLSARIRHMVEFVLQFDAQRLDGWRVVRTEKAFEFTDTQCFYTGLVDRISCSPDARSLAVLDYKTGALPALSDYTDCEKKGRLSDFQIPMYVYLLEQAGYTVTHAFFLDVRKRDFKVIVSNGRVDMGAKRGVDTVQFQAVMQRFEQSVAVFSKAVRQECFAKAPYVTWLECASCRFAPVCRTSYVVRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83871</accession>
    <name>O83871_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71267">
        <property type="entry name" value="B71267"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882344.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0901"/>
    <dbReference type="EnsemblBacteria" id="AAC65854">
        <property type="protein sequence ID" value="AAC65854"/>
        <property type="gene ID" value="TP_0901"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76069">
        <property type="protein sequence ID" value="AGN76069"/>
        <property type="gene ID" value="TPANIC_0901"/>
    </dbReference>
    <dbReference type="GeneID" id="57879412"/>
    <dbReference type="KEGG" id="tpa:TP_0901"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.885"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_12"/>
    <dbReference type="OMA" id="YILIYGN"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="470" mass="51384" checksum="C7DD4D3B9FB0C2AD" modified="1998-11-01" version="1">MLHISSCCRGKRLSRCFGPRAFYVRALCIALPVMLHSFIQTGISFLDNVMVSRLGDVKMGAVNVVNSLLFLYVTALMTVSNAGSVFMTQYSGARHVVGMRQSYRFKQYAMGSLALGAMAAALCCPQYLLSCLLGKNAQAAQIIAEGERYLSIIVYTLVPLSFSLVLTSTLRETGKVLVPLAVYGCSAVLNAVGNYMLIYGNWGAPRLEVQGAACATLIARVVESLMLLVYVRVKKPDFYVRLFCRCAIPLSLCTVMLRKSLWIFVGDMAWSVTEMAVAALYHSRGGAEVVAGMSAGWTLAQLFFLSFPASSVAITILVGDVLGKSELKQAQDYARWLMNGAFFLGLGLGVIVCVARAGIPWAFGDLSHASQRIAQQLVLVTALYMPIWMYLNAQYAVARAGGEVMVTAWTETLVDTLLFLPLMYVLARFTQLGAPLMYGIVKSTSVVKMVVLARHLKTRRWVRNLVANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83885</accession>
    <name>O83885_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71264">
        <property type="entry name" value="H71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882358.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83885">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0915"/>
    <dbReference type="EnsemblBacteria" id="AAC65872">
        <property type="protein sequence ID" value="AAC65872"/>
        <property type="gene ID" value="TP_0915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76083">
        <property type="protein sequence ID" value="AGN76083"/>
        <property type="gene ID" value="TPANIC_0915"/>
    </dbReference>
    <dbReference type="GeneID" id="57879426"/>
    <dbReference type="KEGG" id="tpa:TP_0915"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.899"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599761_0_0_12"/>
    <dbReference type="OMA" id="NKFQVRD"/>
    <dbReference type="OrthoDB" id="941291at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="374"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="444" mass="50768" checksum="E6830A22C73577AD" modified="1998-11-01" version="1">MSSAVIVFFVVMLALSSIMLVATVASKVGTRSSRRKDKESLMREASRRLAQDPYDIRGLSVLGDIHYQDQEWEKAFAMYATLVERSSSSSQMEQFEILLRYGICGVKTEKYAEAKKGLLLAQGIDSHHFEVNYNLGRVYYLDRQYEQVVPLLRRALTSQPDSAPAAQLLGYTFQKLQKYQEALPYLKKALDLQPEDKETLFVMGECFYEANAHDRALKIFNHLRVDPLVGPRAALYAGTIKTKLNQLEDAAEDFEIGLKHDNIPSDVANELRYRLAQTLIKTQNLGRALVMLREIHQLNPEYRDVTALITYYQELNQNRNLHLYMIAAQSEFIGLCRKVVSKYFPHARVKILDISVLNTHTDIVSEIDTPKWADLVLFRFFRSQGSVGELVLRDLHGRIRELKAGKGICMTAGAFTDEARRFAEGRPMDLYDKNRLTRILNSID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83890</accession>
    <name>Y920_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>TPR repeat-containing protein TP_0920</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0920</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71265">
        <property type="entry name" value="E71265"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83890"/>
    <dbReference type="SMR" id="O83890"/>
    <dbReference type="IntAct" id="O83890">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0920"/>
    <dbReference type="PRIDE" id="O83890"/>
    <dbReference type="EnsemblBacteria" id="AAC65878">
        <property type="protein sequence ID" value="AAC65878"/>
        <property type="gene ID" value="TP_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0920"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326228_0_0_12"/>
    <dbReference type="OMA" id="YCIGCAK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <feature type="chain" id="PRO_0000106455" description="TPR repeat-containing protein TP_0920">
        <location>
            <begin position="1"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 4">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 5">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 6">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 7">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 8">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 9">
        <location>
            <begin position="723"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="809" mass="90163" checksum="33BED5768FC3B40E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83893</accession>
    <name>Y923_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0923</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0923</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71265">
        <property type="entry name" value="H71265"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882366.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0923"/>
    <dbReference type="EnsemblBacteria" id="AAC65880">
        <property type="protein sequence ID" value="AAC65880"/>
        <property type="gene ID" value="TP_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0923"/>
    <dbReference type="HOGENOM" id="CLU_049323_0_0_12"/>
    <dbReference type="OMA" id="CAIPEEM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202352" description="Uncharacterized protein TP_0923">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <sequence length="339" mass="36117" checksum="8141ECA98A15B5BC" modified="1998-11-01" version="1">MSYSWKVRALCCAGLCVGAGLRAQEGSGIRVRGMPEHAQVTVNGYLCATPEEMVLTPGECEVTVCAFGYTKKTLQVVVEEGSFTVVDGRLDTARLELTDVTAQRAHFNPRDPAGLNTEYVTFRVTKSAKCTVTVKDAEGKXXCEEPVELVELGLNVGGIFGGSNKNSEDVSVSAKVAFEGNVTSDPAMGQLYASALCLYRIVHNNDSSGANKCFMRKGLTFATTCAYGIKGFTVALSGELGASSETGIKKPDFSTDVGLSLKYQNKICSIATYSKCGTTTGSNSDGANSVAGVSVLRAACKSRDGLGEQLRLQRYSYEGWELRASIGYVINTKLRVGRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>O83902</accession>
    <name>Y932_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0932</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0932</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71264">
        <property type="entry name" value="E71264"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83902"/>
    <dbReference type="IntAct" id="O83902">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65890">
        <property type="protein sequence ID" value="AAC65890"/>
        <property type="gene ID" value="TP_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0932"/>
    <dbReference type="HOGENOM" id="CLU_3405988_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202357" description="Uncharacterized protein TP_0932">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <sequence length="30" mass="3235" checksum="7203C04821B56E04" modified="1998-11-01" version="1">MPVCTSRSLQGGKVDTHFPLHVLHSVACDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>O83916</accession>
    <name>Y950_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0950</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0950</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71261">
        <property type="entry name" value="D71261"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83916"/>
    <dbReference type="EnsemblBacteria" id="AAC65912">
        <property type="protein sequence ID" value="AAC65912"/>
        <property type="gene ID" value="TP_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0950"/>
    <dbReference type="HOGENOM" id="CLU_2385249_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202361" description="Uncharacterized protein TP_0950">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <sequence length="94" mass="10152" checksum="786DA9A9BCC2088F" modified="1998-11-01" version="1">MWLPHAFLRVVSPSALRLMPANGCAVPAGCVQCSNRDVGFATGARVFLCCQTGVRIVGSLLLFGAAMEKPRAQSRTTAFKRGVSCTQKFSRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O83930</accession>
    <name>O83930_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0964</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71259">
        <property type="entry name" value="G71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882408.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0964"/>
    <dbReference type="EnsemblBacteria" id="AAC65919">
        <property type="protein sequence ID" value="AAC65919"/>
        <property type="gene ID" value="TP_0964"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76129">
        <property type="protein sequence ID" value="AGN76129"/>
        <property type="gene ID" value="TPANIC_0964"/>
    </dbReference>
    <dbReference type="GeneID" id="57879474"/>
    <dbReference type="KEGG" id="tpa:TP_0964"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.948"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="235" mass="25177" checksum="FCED3B7716765A61" modified="1998-11-01" version="1">MTPVVRVCNVSKVFPMGDAVVHALRGVSFEIAPAEFVSILGPSGSGKSTCMHMIGCLDRPSSGSVFIAGENTACMSERALAHLRNRTVGFVFQQYFLLPTLTVLENVMLPLRYQGVEYFARRRRAEDELAKVGLSDRLAHRPSELSGGQKQRVAIARALVTRPKIIVADEPTGALDSETGRSVLDLFIEINKKGTAVIIVTHDQGVGALASRSLTLKDGKIVGDHVRGHGGADGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83943</accession>
    <name>LSPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="1">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Signal peptidase II</fullName>
            <shortName evidence="1">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lspA</name>
        <name type="synonym">lsp</name>
        <name type="ordered locus">TP_0978</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65933" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65933.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71257">
        <property type="entry name" value="H71257"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83943"/>
    <dbReference type="SMR" id="O83943"/>
    <dbReference type="IntAct" id="O83943">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0978"/>
    <dbReference type="EnsemblBacteria" id="AAC65933">
        <property type="protein sequence ID" value="AAC65933"/>
        <property type="gene ID" value="TP_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0978"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_3_1_12"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178829" description="Lipoprotein signal peptidase">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="186" mass="20596" checksum="39CC9B7FE8A8618E" modified="2007-05-29" version="2">MKLTRIQKEKWIPLFAAGLVVVLDQCAKLLVGAYVPTNTSGVRVLGDFVRIVHVYNVGAAFSIGHQLNQVLRTLVLGIVPLIIMFLIVFSYFRTDAFCPVQRWAVSGIIGGGIGNLIDRFLRPNGVLDFIDVKFFGIFGFERWPAFNIADAVIMTCGLLLIISFIKQEKEISSQPSCNETGGVFRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83945</accession>
    <name>DUS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable tRNA-dihydrouridine synthase</fullName>
            <ecNumber>1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dus</name>
        <name type="ordered locus">TP_0980</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71258">
        <property type="entry name" value="B71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882424.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83945"/>
    <dbReference type="SMR" id="O83945"/>
    <dbReference type="STRING" id="243276.TPANIC_0980"/>
    <dbReference type="EnsemblBacteria" id="AAC65935">
        <property type="protein sequence ID" value="AAC65935"/>
        <property type="gene ID" value="TP_0980"/>
    </dbReference>
    <dbReference type="GeneID" id="57879489"/>
    <dbReference type="KEGG" id="tpa:TP_0980"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_12"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000162152" description="Probable tRNA-dihydrouridine synthase">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P33371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q5SMC7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="340" mass="37161" checksum="DA20D42AA88AA71C" modified="1998-11-01" version="1">MQQHALYHPVSIGPLSLKGNVFFAPVAGYSDSAFRSIAIEWEASFTYTEMVSSEAMVRDSLNTKRLIRRASNETHYAIQIFGSNPAVMAETAKLIVDSAQPSCIDINAGCPMPKITKTGAGAALTREPTRLYEVVKAVADAVYAQDARIPVTVKIRAGWEEAHLTWKEAARAAVDAGAQALALHPRTCAQCYAGEANWDIIADLVQCARGWGEVPVFGSGDLHAPEDARAMLEHTACAGVMFARGAMGNPFIFRQTRQLLTEGYYTPVTFEQKLRAAWRELHLLAQDVGESSACKQMRKRFVSYAKGERGKTQWCQRAVHASSFADFAAVIRDACPCIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83957</accession>
    <name>O83957_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71256">
        <property type="entry name" value="H71256"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882436.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83957">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0992"/>
    <dbReference type="EnsemblBacteria" id="AAC65948">
        <property type="protein sequence ID" value="AAC65948"/>
        <property type="gene ID" value="TP_0992"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76156">
        <property type="protein sequence ID" value="AGN76156"/>
        <property type="gene ID" value="TPANIC_0992"/>
    </dbReference>
    <dbReference type="GeneID" id="57879501"/>
    <dbReference type="KEGG" id="tpa:TP_0992"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.977"/>
    <dbReference type="HOGENOM" id="CLU_180098_1_0_12"/>
    <dbReference type="OrthoDB" id="1750308at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="95" mass="10147" checksum="0E476F3E91D0A73D" modified="1998-11-01" version="1">MKKKDAFVGTIGYDGQRAVVDRARVLKHSRSSLQELLSAGAFREAAACAVWERSTEALEAVASAYNARSGSRYSAQDIAKVFGIASEPGEKAVVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83966</accession>
    <name>Y1001_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1001</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1001</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71254">
        <property type="entry name" value="C71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882445.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83966"/>
    <dbReference type="STRING" id="243276.TPANIC_1001"/>
    <dbReference type="EnsemblBacteria" id="AAC65958">
        <property type="protein sequence ID" value="AAC65958"/>
        <property type="gene ID" value="TP_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1001"/>
    <dbReference type="eggNOG" id="ENOG5033P4X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787409_0_0_12"/>
    <dbReference type="OMA" id="EITLIFE"/>
    <dbReference type="OrthoDB" id="544297at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202371" description="Uncharacterized protein TP_1001">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <sequence length="393" mass="43440" checksum="5C87488460F77679" modified="1998-11-01" version="1">MQSYEGGVWLTCDIMGVSLFLVREHVVMWDLHRALCAGLLSVLLYGGCSSARDFVHVMKTAGNEVALVHYALQGDCIVFGFRGEVSDVVARVYRAEGVVSEEMSDELLQSFTDEIPSALSRIAVPAAYQESVDAARERLSFFAVRFLQKPHVGQQVVLRGSAQDVAHQKHDFVLPFEGINTQPARLEISEVRPLYGNKRSEFVELLVVESGNLLGITITNVGGKGNRCDYHFPAAQVRVGERVVLHWRKQDPASCDELSAETVSAGSQACARARDFWGQERSIPGRNPNAIVVKESANGKIQDALLFFNTHVKKGKAPTFRWAFPEIEAASRLALEQGAWLSTHEHFPLRESHFFQCDLTPAKSIALKRKRGAGRSAADCFVLKKATMGLPNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83969</accession>
    <name>RECR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">TP_1004</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71254">
        <property type="entry name" value="F71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882448.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83969"/>
    <dbReference type="SMR" id="O83969"/>
    <dbReference type="IntAct" id="O83969">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1004"/>
    <dbReference type="EnsemblBacteria" id="AAC65952">
        <property type="protein sequence ID" value="AAC65952"/>
        <property type="gene ID" value="TP_1004"/>
    </dbReference>
    <dbReference type="GeneID" id="57879515"/>
    <dbReference type="KEGG" id="tpa:TP_1004"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_12"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000190416" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="78"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="201" mass="21800" checksum="10FB4D10CED4D810" modified="1998-11-01" version="1">MIPAIEEVVEHLSRLPGIGVKLATRLAYHLLKRDPAEAQVLARGIACLHERVYRCVCCGAFCEGRTCALCTDASRDRGIICVVERAQDVEMMAGVGEYRGLFHVLGGVIAPLEGVGPDQLRIAALLKRLQESSVREVILALNPTVEGDTTALYVQKILANFPVIVTRLASGIPVGGDLEYIDRTTLAHSLRGRRPLDCSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83996</accession>
    <name>O83996_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_1033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71252">
        <property type="entry name" value="D71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882477.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83996">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1033"/>
    <dbReference type="EnsemblBacteria" id="AAC65980">
        <property type="protein sequence ID" value="AAC65980"/>
        <property type="gene ID" value="TP_1033"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76197">
        <property type="protein sequence ID" value="AGN76197"/>
        <property type="gene ID" value="TPANIC_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1033"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.1021"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_0_0_12"/>
    <dbReference type="OMA" id="TNIMFAE"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="311" mass="33569" checksum="D76FE1A36091AAEF" modified="1998-11-01" version="1">MKWSLVLSGGGARGIAHIGVLKALEALQVPPPQCVVGCSMGAVVGALYALGMSVREMEAFFQRDFVISDYVNARDPSACVEAGMVWGARAAFQRLGKLVQLGVSLNTLVRGLGLDSGEKFATLLTRVTGGKSFHDCKIPFLCNAVNLCTGAEVVLSSGVLARALRASCAYPGVFAPVRQEGVYLADGCILNNTPVWIARAQGFDAVLAVTFDRFEQLGLSDFRTGFDVLLRSLSCASHAVATQARNYPSACVRVETRRDQSDFSRPQELVARGYAAVQHARAVLDVFFARGVRGMLGRRRLARQARAYFER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>P58007</accession>
    <name>YAJC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Sec translocon accessory complex subunit YajC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">yajC</name>
        <name type="ordered locus">TP_0409.1</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="unpublished observations" date="2001-04">
            <authorList>
                <person name="Medigue C."/>
                <person name="Bocs S."/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P58007"/>
    <dbReference type="STRING" id="243276.TPANIC_0409a"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="OMA" id="GMEMIIM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000097036" description="Sec translocon accessory complex subunit YajC">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0ADZ7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="135" mass="14788" checksum="9BFABCF00C0E5876" modified="2001-04-27" version="1">MCPARSRMKTMPHRTLLQITTANGGWIPPLAIGVVCLIFYLFVFAPNLREQKRTQALIKNIKKGDPVVTIGGIHGVVSVVREHSLVIKVNEHGTLEVSRSAIARINDRRGVSNPKTDCDSKPGVPLTGVDKEIAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>P96123</accession>
    <accession>O83381</accession>
    <name>CHEA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chemotaxis protein CheA</fullName>
            <ecNumber>2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cheA</name>
        <name type="ordered locus">TP_0363</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="7" first="267" last="284">
            <title>Identification, sequences, and expression of Treponema pallidum chemotaxis genes.</title>
            <authorList>
                <person name="Greene S.R."/>
                <person name="Stamm L.V."/>
                <person name="Hardham J.M."/>
                <person name="Young N.R."/>
                <person name="Frye J.G."/>
            </authorList>
            <dbReference type="PubMed" id="9255518"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3"/>
    <dbReference type="EMBL" id="U61851">
        <property type="protein sequence ID" value="AAC45555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71335">
        <property type="entry name" value="A71335"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96123"/>
    <dbReference type="SMR" id="P96123"/>
    <dbReference type="STRING" id="243276.TPANIC_0363"/>
    <dbReference type="EnsemblBacteria" id="AAC65348">
        <property type="protein sequence ID" value="AAC65348"/>
        <property type="gene ID" value="TP_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0363"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_2_12"/>
    <dbReference type="OMA" id="MMDMAKS"/>
    <dbReference type="BRENDA" id="2.7.13.3">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037052">
        <property type="entry name" value="CheA-like_P2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <feature type="chain" id="PRO_0000074719" description="Chemotaxis protein CheA">
        <location>
            <begin position="1"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="418"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="663"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by autocatalysis" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC45555." evidence="5" ref="1">
        <original>G</original>
        <variation>E</variation>
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="812" mass="87693" checksum="27EB51B5AD3A557D" modified="1998-12-15" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q56338</accession>
    <name>FLHA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">flhA</name>
        <name type="ordered locus">TP_0714</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="7" first="107" last="116">
            <title>Identification and sequences of the Treponema pallidum flhA, flhF, and orf304 genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Young N.R."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="9063647"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Involved in the export of flagellum proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71290">
        <property type="entry name" value="F71290"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882159.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56338"/>
    <dbReference type="SMR" id="Q56338"/>
    <dbReference type="IntAct" id="Q56338">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0714"/>
    <dbReference type="EnsemblBacteria" id="AAC65680">
        <property type="protein sequence ID" value="AAC65680"/>
        <property type="gene ID" value="TP_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="57879239"/>
    <dbReference type="KEGG" id="tpa:TP_0714"/>
    <dbReference type="eggNOG" id="COG1298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_12"/>
    <dbReference type="OMA" id="MAINPGQ"/>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000190021" description="Flagellar biosynthesis protein FlhA">
        <location>
            <begin position="1"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="707" mass="77944" checksum="12468B80C5922C14" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>O08399</accession>
    <name>GYRB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyrB</name>
        <name type="ordered locus">TP_1006</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="FEMS Microbiol. Lett." volume="153" first="129" last="134">
            <title>Identification and characterization of the gyrB gene from Treponema pallidum subsp. pallidum.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Greene S.R."/>
                <person name="Barnes N.Y."/>
            </authorList>
            <dbReference type="PubMed" id="9252582"/>
            <dbReference type="DOI" id="10.1016/S0378-1097(97)00247-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1585657">
            <id>O08399</id>
        </interactant>
        <interactant intactId="EBI-1584836">
            <id>O83050</id>
            <label>TP_0004</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="U78094">
        <property type="protein sequence ID" value="AAB66715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71254">
        <property type="entry name" value="H71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882450.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O08399"/>
    <dbReference type="SMR" id="O08399"/>
    <dbReference type="IntAct" id="O08399">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1006"/>
    <dbReference type="EnsemblBacteria" id="AAC65954">
        <property type="protein sequence ID" value="AAC65954"/>
        <property type="gene ID" value="TP_1006"/>
    </dbReference>
    <dbReference type="GeneID" id="57879517"/>
    <dbReference type="KEGG" id="tpa:TP_1006"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_2_12"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <feature type="chain" id="PRO_0000145357" description="DNA gyrase subunit B">
        <location>
            <begin position="1"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <sequence length="637" mass="70910" checksum="8131F25CFCDB91E4" modified="1997-07-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83049</accession>
    <name>RECF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">recF</name>
        <name type="ordered locus">TP_0003</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecF family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65001" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65001.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71378">
        <property type="entry name" value="B71378"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83049"/>
    <dbReference type="SMR" id="O83049"/>
    <dbReference type="STRING" id="243276.TPANIC_0003"/>
    <dbReference type="EnsemblBacteria" id="AAC65001">
        <property type="protein sequence ID" value="AAC65001"/>
        <property type="gene ID" value="TP_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0003"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_12"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000196482" description="DNA replication and repair protein RecF">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="352" mass="41216" checksum="22E8B8084CD30DCC" modified="2001-05-04" version="2">MTAINFRNLAHHTIDISSPEVFFVGNNGQGKTNILEVLYLAAYGNSFRTRTESELYATHARSNEYRVKVMYRGEYTHTVQIFSKNGKKRIEKNLKKIRTKKELISSIPCILFFHNDLDFVVGTPERRRFFLDQSLSMCNPLYLEYLQKYHALTKTKNREIKEKRVQLLDALDTQIATVGFDLVQWRTQLVRDFNVIFTKYYERLGDLAQVRIEYKPSWSDSSVEEIVHSLYKRRKHDLAMGMSMSGPHRDKIHFTRSQALFIPQASTGQRRLVSLVLRMSQAVFYTGVTGKLPVLLMDDVLLELDPEKRERFMMSLPPYDQLFCTFLPGEAYRRYGREKTRVYFVSEGACHE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83098</accession>
    <name>Y059_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0059</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0059</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71370">
        <property type="entry name" value="C71370"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881508.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83098"/>
    <dbReference type="IntAct" id="O83098">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0059"/>
    <dbReference type="EnsemblBacteria" id="AAC65063">
        <property type="protein sequence ID" value="AAC65063"/>
        <property type="gene ID" value="TP_0059"/>
    </dbReference>
    <dbReference type="GeneID" id="57879557"/>
    <dbReference type="KEGG" id="tpa:TP_0059"/>
    <dbReference type="HOGENOM" id="CLU_2670011_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014238" description="Uncharacterized protein TP_0059">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="75" mass="8153" checksum="E8B9FC3B39633F7D" modified="1998-11-01" version="1" precursor="true">MRKYLSARSMCCSFFSCAKNCATLGLDSTEGRQFLAVGPQPFASLEGFHGEGGDCLFTTFPPLSIPRRRFCAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83106</accession>
    <name>O83106_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71371">
        <property type="entry name" value="C71371"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881516.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83106">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65060">
        <property type="protein sequence ID" value="AAC65060"/>
        <property type="gene ID" value="TP_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0067"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.72"/>
    <dbReference type="HOGENOM" id="CLU_003728_2_5_12"/>
    <dbReference type="OMA" id="AYYYAIQ"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="393" mass="45769" checksum="E7664EEC7186704F" modified="1998-11-01" version="1">MSYIILTPGGGMGLMGCECSVPPFETVETGKRSVDADRIMRLSRDGYAFLKVNDLERAESEFGKILQIEADNNYALVGLGDAARKRRAYQEASDYYTRCLQHYPRNSYALFGLADCYKNMRRYVKAVEVWQQYLEQDSHNIAVLTRMADAYRKIHDFQNSRNLYSQVIALDEHNSYALIGLAHLHYDFKKYREALIYWKKLLECAEHSVDIRVLTSIGNCYRKMKLFSQGLPYFQEALKRDPGNFYGFFGMADCYRGMNMQERSIQYWEKILEKDTQNRVILTRIADAYRHIGEYEKAHQTYKRALDIDYDAYATLGLAVLCKLQGRYEEAVVSLDRLVQLDRKNYRVYVELADCYRKLGQKQKALETLRPFQQFGVKNRVVSELMSELEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83150</accession>
    <name>O83150_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71364">
        <property type="entry name" value="G71364"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881561.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83150">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0112"/>
    <dbReference type="MEROPS" id="C01.086"/>
    <dbReference type="EnsemblBacteria" id="AAC65103">
        <property type="protein sequence ID" value="AAC65103"/>
        <property type="gene ID" value="TP_0112"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75331">
        <property type="protein sequence ID" value="AGN75331"/>
        <property type="gene ID" value="TPANIC_0112"/>
    </dbReference>
    <dbReference type="GeneID" id="57878655"/>
    <dbReference type="KEGG" id="tpa:TP_0112"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.114"/>
    <dbReference type="eggNOG" id="COG3579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_12"/>
    <dbReference type="OMA" id="WDMIVNL"/>
    <dbReference type="OrthoDB" id="1064956at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="PTHR10363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="450" mass="51243" checksum="27B3A1F9A8B9B763" modified="1998-11-01" version="1">MYLTKELLDTFAHEVAADPIHKAVAGAVARVGLEEAALNTEVARQHTHIFSTETKRGEMTNQKMSGRCWIFAALNAARVNTMKKLDIETVEFSQNYLFFWDKLEKANFFLENILETLDEPLTSRLMAHLLANPVQDGGQWDMFSGLLEKYGLVPKECMPETFHSSNSRVLLAVLTRRLRKHAQLLRSAHEEGVALHTLREKKEAFLSSIYSILVKALGRPPEKFDFVYKDKEKKFHKVRDLTPQKFFCDFVGWDLKNKVSLIHAPTADKPFGRAYTVKFLGTVKEAPCICYVNTPIEVLKEATASAIRAGEPVWFGCDVGQMMTRKDGIMDTEIFGYESMLGTTPEFNKAERLDYGESLLTHAMVITGFDEDAQGNPVRWQVENSWGDDTGKKGMFSMSDRWFDEYLYQITIDKKFVPQVWLDALEKPIIALEPWDPMGALADTPLYLKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83153</accession>
    <name>PDXK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative pyridoxine kinase</fullName>
            <ecNumber>2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>PN/PL/PM kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Pyridoxal kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Pyridoxamine kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Vitamin B6 kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pdxK</name>
        <name type="ordered locus">TP_0115</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ThiD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71365">
        <property type="entry name" value="B71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881564.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83153"/>
    <dbReference type="SMR" id="O83153"/>
    <dbReference type="IntAct" id="O83153">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0115"/>
    <dbReference type="EnsemblBacteria" id="AAC65105">
        <property type="protein sequence ID" value="AAC65105"/>
        <property type="gene ID" value="TP_0115"/>
    </dbReference>
    <dbReference type="GeneID" id="57878658"/>
    <dbReference type="KEGG" id="tpa:TP_0115"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_1_0_12"/>
    <dbReference type="OMA" id="KDEVGYA"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000192037" description="Putative pyridoxine kinase">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="176"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="269" mass="28943" checksum="F6E71F29650993D1" modified="1998-11-01" version="1">MVKLLSIGGSDASGGAGIEADLKTFQEYGAFGVATLTAIVTMDPSRNWSHRVHSLEEDCVRDQLETAFAGVGVSAVKSGMLASVHAIECVAEYLERFAVAAYVFDPVMVCKGSGDALHRELNELMIQKLLPRATVVTPNLFETAQIAGISVPRTVDEMKEGARLIHERGASHVFVKGGGRLPGCKHALDVFYDGKTFHLVEDELVQSGWNHGAGCTVSAAITAGLGRGLTAYDAILSAKRFVTTGLRHGFQVNQWVGTGNLSKWRDRFH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83158</accession>
    <name>Y121_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative L-lysine 2,3-aminomutase</fullName>
            <shortName>LAM</shortName>
            <ecNumber>5.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0121</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the radical SAM superfamily. KamA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71363">
        <property type="entry name" value="H71363"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83158"/>
    <dbReference type="SMR" id="O83158"/>
    <dbReference type="IntAct" id="O83158">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0121"/>
    <dbReference type="EnsemblBacteria" id="AAC65111">
        <property type="protein sequence ID" value="AAC65111"/>
        <property type="gene ID" value="TP_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0121"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_2_0_12"/>
    <dbReference type="OMA" id="VTNQCAM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="chain" id="PRO_0000172294" description="Putative L-lysine 2,3-aminomutase">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="93"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="355" mass="39102" checksum="3D2161D7ACF68E89" modified="1998-11-01" version="1">MSMAECTREQRKRRGAGRADEHWRTLSPASCAADALTEHISPAYAHLIAQAQGADAQALKRQVCFAPQERVVHACECADPLGEDRYCVTPFLVHQYANRVLMLATGRCFSHCRYCFRRGFIAQRAGWIPNEEREKIITYLRATPSVKEILVSGGDPLTGSFAQVTSLFRALRSVAPDLIIRLCTRAVTFAPQAFTPELIAFLQEMKPVWIIPHINHPAELGSTQRAVLEACVGAGLPVQSQSVLLRGVNDSVETLCTLFHALTCLGVKPGYLFQLDLAPGTGDFRVPLSDTLALWRTLKERLSGLSLPTLAVDLPGGGGKFPLVALALQQDVTWHQEREAFSARGIDGAWYTYPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83166</accession>
    <name>Y129_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0129</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0129</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71362">
        <property type="entry name" value="F71362"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83166"/>
    <dbReference type="IntAct" id="O83166">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0129"/>
    <dbReference type="EnsemblBacteria" id="AAC65121">
        <property type="protein sequence ID" value="AAC65121"/>
        <property type="gene ID" value="TP_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0129"/>
    <dbReference type="HOGENOM" id="CLU_1668634_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202195" description="Uncharacterized protein TP_0129">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <sequence length="158" mass="16858" checksum="8B85D4A4DE9FB1AA" modified="1998-11-01" version="1">MQCPVRFAQSCSRMAMFLARNTPSNTLLAFDAGGRPTPGSGCRLGLGRGLLGLCNGQACTPASYKMSSAAAGTAAPARARAWNEVFCVKGMCARVLFLCSTSYQEQGLQQQLFCSYRRTCCGLLLLGRRPCCLCPPSAHLPCLMAPPSDAMPPTRLRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83172</accession>
    <name>Y136_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0136</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0136</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TP013X lipoprotein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65137" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65137.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71360">
        <property type="entry name" value="B71360"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83172"/>
    <dbReference type="IntAct" id="O83172">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0136"/>
    <dbReference type="EnsemblBacteria" id="AAC65137">
        <property type="protein sequence ID" value="AAC65137"/>
        <property type="gene ID" value="TP_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0136"/>
    <dbReference type="HOGENOM" id="CLU_056007_0_0_12"/>
    <dbReference type="OMA" id="HNGCEYL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018067" description="Uncharacterized lipoprotein TP_0136">
        <location>
            <begin position="24"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="485" mass="48984" checksum="C7A4CEEDC7DC5CED" modified="2001-06-01" version="2" precursor="true">MRRRVCTVVRAVVCLLSTSLLTTCDFTGIFAAIQSEVPIKTPSIPGAIYGLVKAGSKLYATNGRLWEKELNGTGSWQKVSSSSVPTDSDKKVMSIATDGNTFVLACVPGTGVYKHCVNGAGSSSTGTTASPSTETCSQHATLVGGTSKPFWLVPGGTGNNGNCGCGGGGGGSSSSSSSCIHIWLVPGGTGNNGNCGCGGGGGGSSSSSSSCIHIKVENTDEQFLDMGEGYVVTTKHLYTKNGSSSAGPAQCPGGGGGGGSSGGGGSSEYTKASCSFSTPILASVSDGCYHYILTKEKVYCRKQDTASSAASSPAQCPSSPSSSSSSSTNAGCEVAHGVDDPLCLAIFKHNGCEYLLIGGSRGYGEIKLEANSSGTNGTCMRLKESNVHKSPGQWGESSPTPKASAEQYRGTVGRFAVQKIYVVEKNGGGNGVAAGGAGCPANASSSSGGTSSTQRPDLYAAVGESSDTYTGLWKFDTTTCSWNRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O83173</accession>
    <name>Y137_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0137</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0137</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71360">
        <property type="entry name" value="C71360"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83173"/>
    <dbReference type="EnsemblBacteria" id="AAC65138">
        <property type="protein sequence ID" value="AAC65138"/>
        <property type="gene ID" value="TP_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0137"/>
    <dbReference type="HOGENOM" id="CLU_3206560_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202198" description="Uncharacterized protein TP_0137">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <sequence length="45" mass="4802" checksum="5C71C235B26EC0E5" modified="1998-11-01" version="1">MLLEPRVTGCFLSSSEQALPPAIYFPLLLLLRSGARNIVGITSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83191</accession>
    <name>O83191_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71359">
        <property type="entry name" value="B71359"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881603.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83191">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0156"/>
    <dbReference type="EnsemblBacteria" id="AAC65146">
        <property type="protein sequence ID" value="AAC65146"/>
        <property type="gene ID" value="TP_0156"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75375">
        <property type="protein sequence ID" value="AGN75375"/>
        <property type="gene ID" value="TPANIC_0156"/>
    </dbReference>
    <dbReference type="GeneID" id="57878699"/>
    <dbReference type="KEGG" id="tpa:TP_0156"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.163"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_7_3_12"/>
    <dbReference type="OMA" id="HIDLFQH"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15367" checksum="58FD457EAEE88CF2" modified="1998-11-01" version="1">MNFSLEFPVRSYELDGYGHVNNAVYLQYFEYARAAFLLHIGFDLKQLHEAGYAFYVTQAHIHYRTAVHLFDTLRARVKPLKLGKASGVFSQTLENQHHVLCADAEITWVCVSRTSGKPTKIPPEYLVPALYPNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O83199</accession>
    <name>Y169_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0169</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0169</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71357">
        <property type="entry name" value="F71357"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83199"/>
    <dbReference type="EnsemblBacteria" id="AAC65161">
        <property type="protein sequence ID" value="AAC65161"/>
        <property type="gene ID" value="TP_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0169"/>
    <dbReference type="HOGENOM" id="CLU_3391919_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202203" description="Uncharacterized protein TP_0169">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <sequence length="32" mass="3616" checksum="C01A97771405398F" modified="1998-11-01" version="1">MWSGLFPDLQGTAFFRAWVASARFRVFHGEGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83204</accession>
    <name>Y174_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0174</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0174</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71358">
        <property type="entry name" value="C71358"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83204"/>
    <dbReference type="IntAct" id="O83204">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0174"/>
    <dbReference type="EnsemblBacteria" id="AAC65164">
        <property type="protein sequence ID" value="AAC65164"/>
        <property type="gene ID" value="TP_0174"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0174"/>
    <dbReference type="HOGENOM" id="CLU_993727_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014241" description="Uncharacterized protein TP_0174">
        <location>
            <begin position="36"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="280" mass="31763" checksum="17FEEA38D9D854B9" modified="1998-11-01" version="1" precursor="true">MQGQVLKKVLKKYVHIGMCTLFLHAILLFPCVAQAVLCQIFLSALIRNTSRMPHTMCSFPSQVTAIFDICACPCAVRSFYLNGNSLIFTGGGHPFSVYASRFSSLPFLETSSGTVAGAAYSVASFLGFTRITSVGTDFSYTNGKPYARGTYLSKQFEQKILRISPLETQFCNLMFRTPTRQDNTQGGITYSNEILDQYKRNFDQITPGARPWHAADFRAFPYKQFINFFHAQLRSKHAAALLAMLPFITWYKTKRTPQAPIFRILELVLEDVLRYTRYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83212</accession>
    <name>O83212_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YrdC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71353">
        <property type="entry name" value="H71353"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0182"/>
    <dbReference type="EnsemblBacteria" id="AAC65168">
        <property type="protein sequence ID" value="AAC65168"/>
        <property type="gene ID" value="TP_0182"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75396">
        <property type="protein sequence ID" value="AGN75396"/>
        <property type="gene ID" value="TPANIC_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0182"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.184"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_2_12"/>
    <dbReference type="OMA" id="LVDAFWP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="259" mass="27744" checksum="2BAFE943EE9102E6" modified="1998-11-01" version="1">MRTCIPLILGMHVRLLHLHVLATRVARCTRCASASLSSCYSCCGVARVRILKHEAQSAHAAARALKAGALVALPTDTVYGFSGLVPHAVPDLICLKARGCTETEGNRREGYPFIALLADPQDVVVYTGTRLPAEFRALWPGPYTFVLRMQDGATQAFRCPADLWLRSVIRAVGGAIFSTSANRHGEPPLQDAQDIDHIFGKHLALTVDAGPLTGSPSAVIDLTHPVPRVLRAGAAPLPLAGLERRDSPSLPHVGEVCKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83225</accession>
    <name>RS3_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">TP_0195</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71355">
        <property type="entry name" value="E71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881642.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83225"/>
    <dbReference type="SMR" id="O83225"/>
    <dbReference type="IntAct" id="O83225">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0195"/>
    <dbReference type="EnsemblBacteria" id="AAC65180">
        <property type="protein sequence ID" value="AAC65180"/>
        <property type="gene ID" value="TP_0195"/>
    </dbReference>
    <dbReference type="GeneID" id="57878733"/>
    <dbReference type="KEGG" id="tpa:TP_0195"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_12"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130226" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="247" mass="27772" checksum="232F8A74C9DE3EC4" modified="1998-11-01" version="1">MGQKVSPIGLRLGINKVWSSRWYAGPREYAALLHEDLRIRSMIRSFPECKNADIAEVEIVRHPQRVTVVMHTARPGVVIGAKGVNIEKIGAEVQKRLNKKVQIKVKEIKRMELNAYLVAQNVARQLTARVSFRKCLRQACAGTMKSGAQGVKIRVSGRLGGAEMSRTEEIKEGRTPLHTLRADIDYGFAEAHTTYGSIGVKVWLYSGMMYGNECRKDVGSLLRRSRRESGQKSDELVRDERTHAERG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83237</accession>
    <name>RL15_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">TP_0207</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71351">
        <property type="entry name" value="E71351"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881655.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83237"/>
    <dbReference type="SMR" id="O83237"/>
    <dbReference type="IntAct" id="O83237">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0207"/>
    <dbReference type="EnsemblBacteria" id="AAC65197">
        <property type="protein sequence ID" value="AAC65197"/>
        <property type="gene ID" value="TP_0207"/>
    </dbReference>
    <dbReference type="GeneID" id="57878745"/>
    <dbReference type="KEGG" id="tpa:TP_0207"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_12"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104848" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="153" mass="16603" checksum="527F9A1035328A2B" modified="1998-11-01" version="1">MADFHLIAPKGANRARRIVGRGSSSGRGTTSGRGTKGQQARAGHKAYVGFEGGQMPLYRRVPRRGFSNCAFKKEYAVVNVGALEFVYAPGETVNRQTLIEKGLVKGRVPFIKILADGELTKSIVVRVDRVSARAQEKIQQAGGSVECIEAQER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83238</accession>
    <name>O83238_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secY</name>
        <name evidence="3" type="ordered locus">TP_0208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71351">
        <property type="entry name" value="F71351"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881656.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83238">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0208"/>
    <dbReference type="EnsemblBacteria" id="AAC65198">
        <property type="protein sequence ID" value="AAC65198"/>
        <property type="gene ID" value="TP_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0208"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.225"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_12"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="450" mass="50265" checksum="892BF3217F3E6E7E" modified="1998-11-01" version="1">MKQGVFAAVFRIRELRARIFFTLSVLTVFRFGSVLTVPSVDPRALSAYFRSQVRGNAFADYMDFFVGGAFSNFSVFMLGVMPYISTQILMQLSMIVFPSLKKVVEDVGGRRRVQFWTRVATVFVCLIQSSAVTVYANQIPGAIVIQSYAVHLFVTMLTVTSGSMITLWLGEQITARGIGNGVSMIIFSGIVARLPHALAEMWRLQRLGELNMVFVIVAFVMFVGIIVLVVYEQQGQRKIPIHYARRVVGRKMYGGQSTYIPFKINPSGVIPIIFASSFLTFPLQIASSIGPNVRFLHQLAQFLRPNSWWYNAFYVVLIVFFAYFYTQVTLNPTEIAKQIRENGGTIPGIRADKTEEYLQGILNRLVLPGSLYLGMIAVLPTLIQAAFGFPSSISLLMGGTSLLILVGVDLDTMSQIEAQLKMRQREGLGGRGKVLPRICSGYLRKDVYEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83270</accession>
    <name>RPOC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">TP_0242</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71350">
        <property type="entry name" value="D71350"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881690.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83270"/>
    <dbReference type="SMR" id="O83270"/>
    <dbReference type="STRING" id="243276.TPANIC_0242"/>
    <dbReference type="EnsemblBacteria" id="AAC65230">
        <property type="protein sequence ID" value="AAC65230"/>
        <property type="gene ID" value="TP_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0242"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_12"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000067823" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="862"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="865"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <sequence length="1416" mass="159790" checksum="78D0EB6A1CAF7C9C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83279</accession>
    <name>LNT1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apolipoprotein N-acyltransferase 1</fullName>
            <shortName evidence="1">ALP N-acyltransferase 1</shortName>
            <ecNumber evidence="1">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lnt1</name>
        <name type="ordered locus">TP_0252</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71348">
        <property type="entry name" value="G71348"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881701.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83279"/>
    <dbReference type="SMR" id="O83279"/>
    <dbReference type="IntAct" id="O83279">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0252"/>
    <dbReference type="EnsemblBacteria" id="AAC65237">
        <property type="protein sequence ID" value="AAC65237"/>
        <property type="gene ID" value="TP_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0252"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_1_12"/>
    <dbReference type="OMA" id="MFNLTND"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178105" description="Apolipoprotein N-acyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="233"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="546" mass="61513" checksum="06E8041A3FB8821E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83281</accession>
    <name>RHO_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription termination factor Rho</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rho</name>
        <name type="ordered locus">TP_0254</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rho family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71346">
        <property type="entry name" value="C71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881703.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83281"/>
    <dbReference type="SMR" id="O83281"/>
    <dbReference type="STRING" id="243276.TPANIC_0254"/>
    <dbReference type="EnsemblBacteria" id="AAC65243">
        <property type="protein sequence ID" value="AAC65243"/>
        <property type="gene ID" value="TP_0254"/>
    </dbReference>
    <dbReference type="GeneID" id="57878795"/>
    <dbReference type="KEGG" id="tpa:TP_0254"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_2_1_12"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0806">Transcription termination</keyword>
    <feature type="chain" id="PRO_0000188982" description="Transcription termination factor Rho">
        <location>
            <begin position="1"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Rho RNA-BD" evidence="2">
        <location>
            <begin position="147"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <sequence length="519" mass="58266" checksum="321A637776025A10" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83283</accession>
    <name>O83283_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71346">
        <property type="entry name" value="H71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881708.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0259"/>
    <dbReference type="EnsemblBacteria" id="AAC65252">
        <property type="protein sequence ID" value="AAC65252"/>
        <property type="gene ID" value="TP_0259"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75471">
        <property type="protein sequence ID" value="AGN75471"/>
        <property type="gene ID" value="TPANIC_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0259"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.263"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108963_0_0_12"/>
    <dbReference type="OMA" id="KHSASKM"/>
    <dbReference type="OrthoDB" id="1862973at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="203" mass="22864" checksum="CC1ADEC6A1C4E3C8" modified="1998-11-01" version="1">MYLVFIGVLCENGPLFCPDCACSLEEETMMRKLSTGLLLWIAFISGVTSCKSAPPAEELVEVAPPVEEQEEEPMTPVPEEPQEPMAVAPQEVSRAEYVVKNEDTLSQIAKKFYGSRIRGYYFPIIMACSEGVVTHPDRIRPGMKLVIPNFDEFMADPDHVRKGLEAFAQVERIYRSEGKMKLAEFMNKLGEKIGKTDPRDMPR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83290</accession>
    <name>Y266_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0266</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0266</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71345">
        <property type="entry name" value="D71345"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83290"/>
    <dbReference type="IntAct" id="O83290">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65261">
        <property type="protein sequence ID" value="AAC65261"/>
        <property type="gene ID" value="TP_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0266"/>
    <dbReference type="HOGENOM" id="CLU_3298111_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202221" description="Uncharacterized protein TP_0266">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <sequence length="41" mass="4905" checksum="16BBA4C533ADBDD2" modified="1998-11-01" version="1">MVRVQRRVLKNFMRVVGVDKGYRLWVEWLSCVCCGYVVRAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83297</accession>
    <name>Y273_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0273</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0273</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71342">
        <property type="entry name" value="D71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881722.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83297"/>
    <dbReference type="IntAct" id="O83297">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0273"/>
    <dbReference type="EnsemblBacteria" id="AAC65275">
        <property type="protein sequence ID" value="AAC65275"/>
        <property type="gene ID" value="TP_0273"/>
    </dbReference>
    <dbReference type="GeneID" id="57878817"/>
    <dbReference type="KEGG" id="tpa:TP_0273"/>
    <dbReference type="HOGENOM" id="CLU_1065349_0_0_12"/>
    <dbReference type="OMA" id="FFDGWDN"/>
    <dbReference type="OrthoDB" id="1827826at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202222" description="Uncharacterized protein TP_0273">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="263" mass="29742" checksum="9C40AF87E126E430" modified="1998-11-01" version="1">MLPYAEVILFLIKKHCIDCGEAFFGIVVLNALCLAGVGYSLLWHQGPGRSVLFVLVLATLYACLCAFCVVRGERGCDTLADTNLRVFTHALREVWLQSLWCALLQCVLFRTGKYVCTYYFARTHSVFTACGILSAWTYALACGALLWFVPVRARYRTHFRQCVYLSARVFFEHPCITFLMVLYSMGVLALSVPMAFLFPGPCGIVLLWQDVLRTLCFRRAWLAAHEGRKAACAPPIPWEQLMCQMRAQSRAHTVGELFSPWKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>O83305</accession>
    <name>Y281_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0281</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0281</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71343">
        <property type="entry name" value="D71343"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83305"/>
    <dbReference type="IntAct" id="O83305">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65278">
        <property type="protein sequence ID" value="AAC65278"/>
        <property type="gene ID" value="TP_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0281"/>
    <dbReference type="HOGENOM" id="CLU_3259313_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202225" description="Uncharacterized protein TP_0281">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <sequence length="42" mass="4462" checksum="F9FBAD73F78BCD7F" modified="1998-11-01" version="1">MYLAVVPVCCSFPWAGVGLRCSRLSVRVLELSDSVRGGGIHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83306</accession>
    <name>Y282_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>TPR repeat-containing protein TP_0282</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0282</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71343">
        <property type="entry name" value="E71343"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881731.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83306"/>
    <dbReference type="SMR" id="O83306"/>
    <dbReference type="IntAct" id="O83306">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0282"/>
    <dbReference type="EnsemblBacteria" id="AAC65279">
        <property type="protein sequence ID" value="AAC65279"/>
        <property type="gene ID" value="TP_0282"/>
    </dbReference>
    <dbReference type="GeneID" id="57878823"/>
    <dbReference type="KEGG" id="tpa:TP_0282"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105450_0_0_12"/>
    <dbReference type="OMA" id="DDASIWF"/>
    <dbReference type="OrthoDB" id="1444515at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000106454" description="TPR repeat-containing protein TP_0282">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="239" mass="26435" checksum="6483B788934BFE73" modified="1998-11-01" version="1">MHEQRRGIVRVDRFLELHRRLLVGVLVAILGGLGLSAGCLLVMTRLRARASAEVTRIAREWDVLRKPDNTVSASGHEVEGRGGSSIRAKEDALLARLESCASSPWRDGFAYAYAQACVADIFFARKEWEKAQQAYVRAAYGARRSYVAGVYYFNAASCADERGRFEEARELYQRSARVQDFPLVPRALFNVGRMEEALGRAAAATAAYMQLYERFPLNGWAALGKSRAIAISVGGGRAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-03-28" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83323</accession>
    <name>RFUC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable riboflavin import permease protein RfuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfuC</name>
        <name evidence="5" type="ordered locus">TP_0301</name>
        <name evidence="6" type="ORF">TPANIC_0301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00615" last="E00615">
            <title>Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Biddy B.A."/>
                <person name="Liu W.Z."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="23404400"/>
            <dbReference type="DOI" id="10.1128/mBio.00615-12"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71341">
        <property type="entry name" value="G71341"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881750.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83323"/>
    <dbReference type="IntAct" id="O83323">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0301"/>
    <dbReference type="TCDB" id="3.A.1.2.28">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65289">
        <property type="protein sequence ID" value="AAC65289"/>
        <property type="gene ID" value="TP_0301"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75505">
        <property type="protein sequence ID" value="AGN75505"/>
        <property type="gene ID" value="TPANIC_0301"/>
    </dbReference>
    <dbReference type="GeneID" id="57878837"/>
    <dbReference type="KEGG" id="tpa:TP_0301"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0301"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.301"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_3_12"/>
    <dbReference type="OMA" id="VYFGAFF"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443720" description="Probable riboflavin import permease protein RfuC">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23404400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="23404400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AGN75505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="377" mass="40888" checksum="DDEE6D472F25AFA8" modified="1998-11-01" version="1">MKRVINSCIAVLLGVAVMSAVIVLCSENPSVSLAAFFLKPFSTRGYIRALFHKAGLFVCMALGASCALKTGMINLGGDGQIYAAGFVTALLLREYWGVGFLLQWSVALLCALSVAGILACVSGILKAWLATSEMITSFLLSTACVPLIDALIITVTRDPAGNLLATAPVHSHFILQQQTSLFGVPAVLTYASLVALAVGCFFSYTRVGYQFRICGKAPEFGRFVGFPVWATYVWGMVLSGALFGLTGFFSVVGLFGTCYVGFSVGMGYAALAHALIAHAHITVLVPLAFFFAWMETASEAAVLGAHLTVNVVLFLQAAIFLLISAQWSAPWNAVRRGARRVYRFLVTVFCFRGEKHRTRRRHALSVHDTHHRRSRWE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83351</accession>
    <name>6PGD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber>1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gnd</name>
        <name type="ordered locus">TP_0331</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71337">
        <property type="entry name" value="A71337"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881779.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83351"/>
    <dbReference type="SMR" id="O83351"/>
    <dbReference type="STRING" id="243276.TPANIC_0331"/>
    <dbReference type="EnsemblBacteria" id="AAC65319">
        <property type="protein sequence ID" value="AAC65319"/>
        <property type="gene ID" value="TP_0331"/>
    </dbReference>
    <dbReference type="GeneID" id="57878863"/>
    <dbReference type="KEGG" id="tpa:TP_0331"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_12"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <keyword id="KW-0521">NADP</keyword>
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        <location>
            <begin position="1"/>
            <end position="488"/>
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            <begin position="9"/>
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        </ligand>
    </feature>
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        <location>
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        <location>
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        </ligand>
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        </ligand>
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    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="488" mass="52767" checksum="FB69CCCA98DEE6B5" modified="1998-11-01" version="1">MGADIGFIGLAVMGENLVLNIERNGFSVAVFNRTTTVVDRFLAGRAHGKRITGAHSIAELVSLLARPRKIMLMVKAGSAVDAVIDQILPLLEKGDLVIDGGNSHYQDTIRRMHALEAAGIHFIGTGVSGGEEGALRGPSLMPGGSAQAWPLVSPIFCAIAAKADDGTPCCDWVGSDGAGHYVKMIHNGIEYGDMQIIAEGYWFMKHALGMSYEHMHHTFTRWNTGRLHSYLIEITAAILAHQDTDGTPLLEKILDAAGQKGTGRWTCVAALEEGSPLTLITESVMARSLSAQKQARCKAHRVFGSPVKVSKAETLSAQQREELVSALEDALYCAKIVSYAQGFELLSHTAKRRGWTLDFSRIASLWRGGCIIRSGFLSKISAAFAQQHDLENLVLAPFFAEELKRACPGWRTIVAESVRQALPVPALSAALAWFDGFTGAALPANLLQAQRDYFGAHTYERTDAPRGEFFHTNWTGTGGDTIAGTYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83353</accession>
    <name>O83353_TREPA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TP_0333</name>
    </gene>
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        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="57878864"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
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        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
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    </dbReference>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014585736" evidence="1">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="230" mass="25559" checksum="99C4451785B306E9" modified="1998-11-01" version="1">MRRRRRFLTLCACAVHLLPLFPQTITTASVFFASVSEHYARLKDYAADLAMSTGSGTRAHLMRAKVIFKYPDRLRLDFSSPAEQTIVFTGDSLTIYLPTSRVALVQSVAKDDTVSAASLASPHGLALMKRFYTIAYETSSSPVPLGPDSGEMVVALVLNRKSAAETFKSLRVLVSAHTKLIRRIEAWPLSGEKITFDFSHYRLNVGIPDTRFLYDVPPTANVVHNFLFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83403</accession>
    <name>O83403_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein (FtsQ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
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            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="F71331"/>
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    </dbReference>
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        <property type="gene ID" value="TPANIC_0388"/>
    </dbReference>
    <dbReference type="GeneID" id="57878914"/>
    <dbReference type="KEGG" id="tpa:TP_0388"/>
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    </dbReference>
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    <dbReference type="OMA" id="YYFIASD"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="271" mass="30594" checksum="252AD14F847FE0DF" modified="1998-11-01" version="1">MKKQFLCRNTEACKYPLVGYMSMRVRVAVLKVVIVILLLVLCVEFVFYLFVVPATSFAKVEFSGNVTISPEYLMKAAGLTGKEKWMSLDGFTISERLASVPLLAQVEVLKKFPDTMHVHVVERVAIALGFVHVQGRAMPVQIDKTGTVFSVGTAPLDTVLPVVSGLEFRNPRVGLRVHDQLVPLFVQLDNLSKRNPLLLGEISEISIEQKRHGGYDLALYLVRAPIRVRMDKNLSEEKLRYVILLVDALREWQTQRRIKELDVRGGTAVYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83426</accession>
    <name>SECF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Protein translocase subunit SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secF</name>
        <name type="ordered locus">TP_0411</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71327">
        <property type="entry name" value="A71327"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881859.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83426"/>
    <dbReference type="IntAct" id="O83426">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0411"/>
    <dbReference type="EnsemblBacteria" id="AAC65399">
        <property type="protein sequence ID" value="AAC65399"/>
        <property type="gene ID" value="TP_0411"/>
    </dbReference>
    <dbReference type="GeneID" id="57878937"/>
    <dbReference type="KEGG" id="tpa:TP_0411"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_12"/>
    <dbReference type="OMA" id="RMEFNTT"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000095989" description="Protein translocase subunit SecF">
        <location>
            <begin position="1"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <sequence length="420" mass="45731" checksum="D7FC706AF596F6F1" modified="1998-11-01" version="1">MRQVVRFSLLFLPCAILSVVLIGAGVLRWALWGMSFGIDFQSGLIERLRIAPPAFSLVYTGTQSMQFFQDEQKVVFTVSSPGVLGERYEFLYTEYPTLRAFSEGAKKVEHLSVTLHAPETVYMRDTFSGAEGSTLSSASCFVHYFSEDVRAPGVEELRRVLKDVPSAVVQQVGVRAEHTFQVRVAAETAFPSSLLPEQGGTALAQSDAPDLVTPQGAVESVVYAALVRAYGADHVVRLAMDFVGSRFSHLLVRQALLLVLGALVLIFLYVALRFRWFFALGAIVALVHDACIMVSFMVWFGLEFNSASIAAILTIIGYSINDTVVVFDRVRQTILLDPIASVTTVLDRSQTDMLTRTVVTTVTTLLAALMLYVFTEGGSRDFSLALMVGMVSGVYSTIYIAGGCIALISRGKSGGQLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83427</accession>
    <name>O83427_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71327">
        <property type="entry name" value="B71327"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881860.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83427">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0412"/>
    <dbReference type="EnsemblBacteria" id="AAC65400">
        <property type="protein sequence ID" value="AAC65400"/>
        <property type="gene ID" value="TP_0412"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75607">
        <property type="protein sequence ID" value="AGN75607"/>
        <property type="gene ID" value="TPANIC_0412"/>
    </dbReference>
    <dbReference type="GeneID" id="57878938"/>
    <dbReference type="KEGG" id="tpa:TP_0412"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.412"/>
    <dbReference type="eggNOG" id="ENOG5033EE8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144077_0_0_12"/>
    <dbReference type="OMA" id="TRSNDYY"/>
    <dbReference type="OrthoDB" id="1805213at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021694">
        <property type="entry name" value="DUF3276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11680">
        <property type="entry name" value="DUF3276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11930" checksum="4886A210853DF5C6" modified="1998-11-01" version="1">MGIRGELFTTEVQAENRTYFFNVKENRVGDVFLQVVESKNVDGAGFDRHAVVVFEEEMQKFLQGFNRSLDFLEKNKKERLHLRQARSLHTRGERKTIVRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-05-25" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83444</accession>
    <name>VATI1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit I 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit I 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpI1</name>
        <name type="ordered locus">TP_0429</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71326">
        <property type="entry name" value="B71326"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881877.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83444"/>
    <dbReference type="SMR" id="O83444"/>
    <dbReference type="STRING" id="243276.TPANIC_0429"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65415">
        <property type="protein sequence ID" value="AAC65415"/>
        <property type="gene ID" value="TP_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0429"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_1_1_12"/>
    <dbReference type="OMA" id="INESYAW"/>
    <dbReference type="OrthoDB" id="259071at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000119242" description="V-type ATP synthase subunit I 1">
        <location>
            <begin position="1"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="622" mass="69077" checksum="2AECAD4E47821C91" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83447</accession>
    <name>Y432_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0432</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0432</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71326">
        <property type="entry name" value="E71326"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881880.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83447"/>
    <dbReference type="IntAct" id="O83447">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0432"/>
    <dbReference type="EnsemblBacteria" id="AAC65420">
        <property type="protein sequence ID" value="AAC65420"/>
        <property type="gene ID" value="TP_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0432"/>
    <dbReference type="HOGENOM" id="CLU_1517273_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202254" description="Uncharacterized protein TP_0432">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <sequence length="183" mass="19537" checksum="75759BE26C369A35" modified="1998-11-01" version="1">MSGGVGVGKRLCCIALVMRAFWYLSAKGVSIAYVPVHRSGGSQDSSMSTAVGDTLLNAFFDEGMVVTAVPPGVHDGQTIAEIAACFEVMPDYALLVQFHSARLPGGESPTSRARGAWSSERFRAVWTLVDLHTQRACVYACVAPYRESIPVSECVDVVTRCIAEQAISYIRVGTSTDTAGVQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83461</accession>
    <name>Y447_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0447</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0447</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71324">
        <property type="entry name" value="G71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881895.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83461"/>
    <dbReference type="STRING" id="243276.TPANIC_0447"/>
    <dbReference type="EnsemblBacteria" id="AAC65436">
        <property type="protein sequence ID" value="AAC65436"/>
        <property type="gene ID" value="TP_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0447"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063467_0_0_12"/>
    <dbReference type="OMA" id="WIGEVYR"/>
    <dbReference type="OrthoDB" id="1691271at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014248" description="Uncharacterized protein TP_0447">
        <location>
            <begin position="27"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="374" mass="43127" checksum="F7EE331ED9743320" modified="1998-11-01" version="1" precursor="true">MNNLIKAYAAGVMSAAFLFGSEGRVRSESDRVRGEDPWHLLQWAQVVYEREEFGDTLRYAQRARALRREQVEHQCRVLLRARTRAESAGIPETLSDLYALLKSRGETDACEVLDAIFLTHAPHVFQNSVSKLLQWLKDSAAFPEAELLLGKVFEGEGEYAQALQHYRNAWDTRAQLVVPDARFDIIYAMANVSRLLSQQDEREKYLLLVLSEDPLYSAREVWGKTLHAMLRTIRSSNTVEKFFKLYRHRNVLALRAYQELTEMYVRTDNIERALPVSVLAADIAISALDSFLQKIELTYQYKDLADLFLRTGSHPTILKWANEHGVWQTLLHFADLLYKKGLHAQARDMYYNLAEKCPAFEYARRAAYKLSLTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83464</accession>
    <name>EFG2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor G 2</fullName>
            <shortName>EF-G 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fusB</name>
        <name type="synonym">fusA-1</name>
        <name type="ordered locus">TP_0450</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71322">
        <property type="entry name" value="C71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881898.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83464"/>
    <dbReference type="SMR" id="O83464"/>
    <dbReference type="STRING" id="243276.TPANIC_0450a"/>
    <dbReference type="PRIDE" id="O83464"/>
    <dbReference type="EnsemblBacteria" id="AAC65438">
        <property type="protein sequence ID" value="AAC65438"/>
        <property type="gene ID" value="TP_0450"/>
    </dbReference>
    <dbReference type="GeneID" id="57878974"/>
    <dbReference type="KEGG" id="tpa:TP_0450"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_12"/>
    <dbReference type="OMA" id="AVCQIPW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091255" description="Elongation factor G 2">
        <location>
            <begin position="1"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="683" mass="75802" checksum="E0543E02FAA72AF1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O83477</accession>
    <name>TRMB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">TP_0464</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71321">
        <property type="entry name" value="B71321"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881913.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83477"/>
    <dbReference type="SMR" id="O83477"/>
    <dbReference type="IntAct" id="O83477">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0464"/>
    <dbReference type="EnsemblBacteria" id="AAC65448">
        <property type="protein sequence ID" value="AAC65448"/>
        <property type="gene ID" value="TP_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0464"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_0_1_12"/>
    <dbReference type="OMA" id="PDPWHKS"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000171416" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="250" mass="28068" checksum="C5A227F4E4D15CC0" modified="1998-11-01" version="1">MTNDSARMRKVLTFTRRSNRMTACQKRDYQHLASRWIIPYQNTVFDYAAVFCSPAAPSAPAGAFPAPQGKTDAVAPACAPAPLVVEIGFGMGSATAAIAARNPHLSYLGIEVYRAGIGRLLRKIEAERLHNLRIIEHDALDVLRTMIAPQTLAGLHIFFPDPWPKTRHHKRRLLYRPRTDLLARALAPGGYLYAVTDWAEYARRAQEELARTPSLTWAPQGARPWRPATEFERKAQTQGRAIHELFFIKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83479</accession>
    <name>Y466_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0466</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0466</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71321">
        <property type="entry name" value="D71321"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881915.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83479"/>
    <dbReference type="IntAct" id="O83479">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0466"/>
    <dbReference type="EnsemblBacteria" id="AAC65459">
        <property type="protein sequence ID" value="AAC65459"/>
        <property type="gene ID" value="TP_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="57878989"/>
    <dbReference type="KEGG" id="tpa:TP_0466"/>
    <dbReference type="eggNOG" id="ENOG5033SDH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058631_0_0_12"/>
    <dbReference type="OMA" id="TENANIY"/>
    <dbReference type="OrthoDB" id="674013at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202259" description="Uncharacterized protein TP_0466">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <sequence length="389" mass="44762" checksum="A6FA84E46AB11C12" modified="1998-11-01" version="1">MSSKHKRRILNLPLKLVLTQEGSEFFIKQNRKLMKLKLAEHVEDYGIALDAFAPKTVQGLLLSGYVSLIEVSPPEFASSRQEIIDLSKLIVHSILYRQYDCYVFRQILNSEVIKKWNRSNPGSSIDEHANLNAPFIYNHLKQHEAHVTQIKHHILRLLHASLAACEERTPKEKNTLLFLGEKFLDTLRPFTWFIISKFQHAPDMGSVLSSIHTSLAQYLNKARIAEYIALVLVELLINEENTNLKKEVQKLFPDLEDAQEALCDEGIRRRIVAELKHNAESLFISWKLQGRSVSTAGTRRKLKITVYGRNDYPQEMRNCLQDAKVVNADTDTLVDYCQQTIDTAKHANLGVYYISYLSEACKEANVRFESSLNRFTRSEFTTVDLSFEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83486</accession>
    <name>Y473_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0473</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0473</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71318">
        <property type="entry name" value="G71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881922.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83486"/>
    <dbReference type="IntAct" id="O83486">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0473"/>
    <dbReference type="EnsemblBacteria" id="AAC65467">
        <property type="protein sequence ID" value="AAC65467"/>
        <property type="gene ID" value="TP_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0473"/>
    <dbReference type="HOGENOM" id="CLU_1288413_0_0_12"/>
    <dbReference type="OMA" id="FFLISWS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202261" description="Uncharacterized protein TP_0473">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="214" mass="24002" checksum="1497AA7E15DFAE92" modified="1998-11-01" version="1">MVTVSIVEIFLIISLPLLFFSSFADAGDPLQELISFVHGAVLAVPLLLLRSFFLGYYPPDSALVEEQWMRFFLFDYVFPLFCLPFFLFTSRSLERVSLVSGVSALFGAYTSFFFVHVYTQLNDPDLLARVMTLVLYMTNLLQLHAHVSFSMRTRLPLLGLIAALCIFLLMGAFSATVMTLCFFNARTVVYTSMLAGAGGVALLTHFFAVRINVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83502</accession>
    <name>O83502_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71318">
        <property type="entry name" value="A71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881938.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83502">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0489"/>
    <dbReference type="EnsemblBacteria" id="AAC65476">
        <property type="protein sequence ID" value="AAC65476"/>
        <property type="gene ID" value="TP_0489"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75680">
        <property type="protein sequence ID" value="AGN75680"/>
        <property type="gene ID" value="TPANIC_0489"/>
    </dbReference>
    <dbReference type="GeneID" id="57879011"/>
    <dbReference type="KEGG" id="tpa:TP_0489"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.486"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_1_0_12"/>
    <dbReference type="OMA" id="NDQMLHP"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="61"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="322" mass="37032" checksum="BB3B1EBEAC496C01" modified="1998-11-01" version="1">MRVHFWGVRGSVPTPVTPRQVQSKIAAVVQRISAKDVRNQRSKERFISDLPAWLFGTTGGNTTCVEMETDCGETLIFDAGTGIRDLGIDLMSRPGYRAQGHVYHLLFTHFHWDHIQGLPFFNPAFDPRNTIIVYSTRKKMKEFLEDQMRYPYFPISMFGRDGFNAKFEFRLIGNHEECFAIGKTKITWNRVRHPGGCVSYAVSEAGGKKVIFSTDTELRQKDFDRSERNVCFYDAASLLIIDSQYTMTESIKKEGWGHSTFSIVVDFAVSWGVRRLALFHHEPTYDDKKLFSILQNACWYRKYVGAHDLEILLAQEGKDIFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83505</accession>
    <name>DNAG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase</fullName>
            <ecNumber evidence="1">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaG</name>
        <name type="ordered locus">TP_0492</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71318">
        <property type="entry name" value="D71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881941.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83505"/>
    <dbReference type="SMR" id="O83505"/>
    <dbReference type="IntAct" id="O83505">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0492"/>
    <dbReference type="EnsemblBacteria" id="AAC65479">
        <property type="protein sequence ID" value="AAC65479"/>
        <property type="gene ID" value="TP_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0492"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_3_12"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000180531" description="DNA primase">
        <location>
            <begin position="1"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <sequence length="605" mass="67893" checksum="C43E715EC41911A4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83519</accession>
    <name>TIG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Trigger factor</fullName>
            <shortName>TF</shortName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tig</name>
        <name type="ordered locus">TP_0506</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71314">
        <property type="entry name" value="A71314"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881955.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83519"/>
    <dbReference type="SMR" id="O83519"/>
    <dbReference type="IntAct" id="O83519">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0506"/>
    <dbReference type="EnsemblBacteria" id="AAC65494">
        <property type="protein sequence ID" value="AAC65494"/>
        <property type="gene ID" value="TP_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0506"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_1_12"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000179455" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type">
        <location>
            <begin position="170"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="442" mass="49939" checksum="8F5ED72A6795120F" modified="1998-11-01" version="1">MELQKKFTALAQSQVELEVVVAREDAQRHYQRFVEEYLERARLPGFRKGKVPLAVLERKYGSAIRQDAAAALMEKALEEGFAQASQDSQPLPISRPSLKKKPVFDPDEDFSFAVIYDVFPSVELRNTSGFSLSVPTVSVTEEDVSRELTRIQERNALVTDKGADSCAEVGDIATVDYHEVDDSGAVRPGTERAGVVFTLGVEEGPFALGQDILGMKLGQRCLFAKRAGMLKDEAAQVRVTLKALKQRQLPSLDDELAQDVSDAFRTLDDLTRSVRQNLAEALEAALHEYKRRQLLRILVRENPFSLPESLVVGEMESRWALVMRQFGVSLSGTPQNKLQFFQQWRPEVEEHLKQRVIVELLLKQEQVSVSAEEIETEYVRIASKTGSKEERVREYYAGEEKRRALCEGIRERKLCQKLLGRCVTECGPEQSLTDFLQEQSRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83523</accession>
    <name>LEPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">TP_0510</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71314">
        <property type="entry name" value="E71314"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881959.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83523"/>
    <dbReference type="SMR" id="O83523"/>
    <dbReference type="IntAct" id="O83523">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0510"/>
    <dbReference type="EnsemblBacteria" id="AAC65498">
        <property type="protein sequence ID" value="AAC65498"/>
        <property type="gene ID" value="TP_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0510"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_12"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176366" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="605" mass="67623" checksum="BA537DEC26FD3349" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83525</accession>
    <name>ISPDF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional enzyme IspD/IspF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
                <ecNumber evidence="1">2.7.7.60</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">MEP cytidylyltransferase</fullName>
                <shortName evidence="1">MCT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
                <shortName evidence="1">MECDP-synthase</shortName>
                <shortName evidence="1">MECPP-synthase</shortName>
                <shortName evidence="1">MECPS</shortName>
                <ecNumber evidence="1">4.6.1.12</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispDF</name>
        <name type="ordered locus">TP_0512</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">In the C-terminal section; belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="1"/>
    <dbReference type="EC" id="4.6.1.12" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71314">
        <property type="entry name" value="G71314"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83525"/>
    <dbReference type="SMR" id="O83525"/>
    <dbReference type="IntAct" id="O83525">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0512"/>
    <dbReference type="EnsemblBacteria" id="AAC65500">
        <property type="protein sequence ID" value="AAC65500"/>
        <property type="gene ID" value="TP_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0512"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042800_2_2_12"/>
    <dbReference type="OMA" id="TGYDVHA"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000075678" description="Bifunctional enzyme IspD/IspF">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" evidence="1">
        <location>
            <begin position="244"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="399" mass="42456" checksum="70EADFB0A46676CC" modified="1998-11-01" version="1">MRRGGACVQKKEYLPLTSRQPGVCLLSEILVRALEARSFFLVVVTVPAGEVAYAESQVACDSRLSAFPSRTRPVILYVPGAHTRSASVRAGLDAMATHAPDVVLVHDGARPFVSVALIHSVLEATCRYGAAVPVIEATDTPKGVAADGSIETHLIRSRVRLAQTPQGFCYASLCAAHHRAATDGEQYTDDSELYARYGGTVHVCAGERSNVKITYPEDLEQRASEPALTRGISVLPCTEEGALRVGLGTDMHALCAGRPLILAGIHIPSKKGAQGHSDADVLAHASIDALLGAAGLGDIGTFFPSCDGRWKDAHSCALLRHTWQLVRAACWRLVNLDAVVCLEQPALHPFREAMRASLAQALDTHVTRVFVKAKTAERLGPVGSGAAVTAQVVVLLKKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O83535</accession>
    <name>MURG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">TP_0523</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71316">
        <property type="entry name" value="A71316"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881971.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83535"/>
    <dbReference type="SMR" id="O83535"/>
    <dbReference type="STRING" id="243276.TPANIC_0523"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65509">
        <property type="protein sequence ID" value="AAC65509"/>
        <property type="gene ID" value="TP_0523"/>
    </dbReference>
    <dbReference type="GeneID" id="57879046"/>
    <dbReference type="KEGG" id="tpa:TP_0523"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_0_12"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000109233" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="384" mass="42049" checksum="205E2377076F36B3" modified="1998-11-01" version="1">MRFRARVSQSTAKCVVFTGGGTGGHIFPGIAVFQALAQQAAVRVVWIGAARGADRSIVESAGLEFCGITAGKWRRYASVRNFFDVFRVLVGTVQSYCILRALRPQALFSKGGFVSVPPCIAAWLLRIPVVTHESDISPGLATRINARFADRILVSYPHTSCYFPRARRAAVHCTGNPVRQDFFSAQAERAYQFLRIDQKKPLLTVLGGSSGARDLNARVLSCSTFLTERFYLVHQFGAGNEDQMHTITNSLSVNARHAYMSFPFIQAHLPDILAASALVLSRAGANAVWECAVLGKPMILFPLERGSSRGDQIENAEYFSAHGAACILRAQDEKGHQLVSLLTELFHPSCARIEEMARASYTLGIGNAAYDIAQQLQTFIKEGM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83539</accession>
    <name>VATD2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit D 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit D 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpD2</name>
        <name type="ordered locus">TP_0527</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71313">
        <property type="entry name" value="A71313"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881975.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83539"/>
    <dbReference type="SMR" id="O83539"/>
    <dbReference type="IntAct" id="O83539">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0527"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65514">
        <property type="protein sequence ID" value="AAC65514"/>
        <property type="gene ID" value="TP_0527"/>
    </dbReference>
    <dbReference type="GeneID" id="57879051"/>
    <dbReference type="KEGG" id="tpa:TP_0527"/>
    <dbReference type="eggNOG" id="COG1394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_0_12"/>
    <dbReference type="OMA" id="SKNIMGV"/>
    <dbReference type="OrthoDB" id="1334900at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144274" description="V-type ATP synthase subunit D 2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="209" mass="23926" checksum="0647A0E11B7DE62B" modified="1998-11-01" version="1">MKTPLAPTKSNLAYVRDQLGLARDGYRLLEQKREILFMELTSLLEEVHLLETELDKRRKQAYASLWQLLLAQGRDDIAACALVTPVPCRVQQEVLLIAGLRFLRLDAVMQPPKLQYAALGSSACMDRAREDFGLLLQTLTRMASVQTIVWRLASEMRKTQRRVNALSKQIIPQMCETCMYIESVLEERDRESTFVLKSLKARKDPTTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83542</accession>
    <name>O83542_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">V-type ATPase, subunit E, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71313">
        <property type="entry name" value="D71313"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881978.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83542">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0530"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65517">
        <property type="protein sequence ID" value="AAC65517"/>
        <property type="gene ID" value="TP_0530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75718">
        <property type="protein sequence ID" value="AGN75718"/>
        <property type="gene ID" value="TPANIC_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="57879054"/>
    <dbReference type="KEGG" id="tpa:TP_0530"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.526"/>
    <dbReference type="eggNOG" id="ENOG50301BP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1320395_0_0_12"/>
    <dbReference type="OMA" id="ACAELND"/>
    <dbReference type="OrthoDB" id="1978969at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="208" mass="23578" checksum="301E7E9B4BA0B0F4" modified="1998-11-01" version="1">MEELRSTEVLERDIYAEARKRADHILSCARADCAQLEAHASARVQDITRAVEQLFAQRIAAYERNAQAVIPLERIRQTIRAVDARVQRALASYFEKIGEEKRLRVLARLLERYAPLIGEQKITVRFFGYCESRVRDLLNQALPRAVLRSLTPFDKAEAWRAQCSDGLTIETEDGTLQCRSTIEEICAQLLSEKRQELACALCGNGVVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83575</accession>
    <name>Y564_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0564</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0564</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71308">
        <property type="entry name" value="B71308"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882011.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83575"/>
    <dbReference type="IntAct" id="O83575">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0564"/>
    <dbReference type="PRIDE" id="O83575"/>
    <dbReference type="EnsemblBacteria" id="AAC65547">
        <property type="protein sequence ID" value="AAC65547"/>
        <property type="gene ID" value="TP_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0564"/>
    <dbReference type="eggNOG" id="ENOG502ZX8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422063_0_0_12"/>
    <dbReference type="OMA" id="WENHYLA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202274" description="Uncharacterized protein TP_0564">
        <location>
            <begin position="1"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="678" mass="76524" checksum="FBCEE74A937804EB" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83576</accession>
    <name>O83576_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="C71308"/>
    </dbReference>
    <dbReference type="IntAct" id="O83576">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0565"/>
    <dbReference type="EnsemblBacteria" id="AAC65548">
        <property type="protein sequence ID" value="AAC65548"/>
        <property type="gene ID" value="TP_0565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75752">
        <property type="protein sequence ID" value="AGN75752"/>
        <property type="gene ID" value="TPANIC_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0565"/>
    <dbReference type="eggNOG" id="COG2845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587847_0_0_12"/>
    <dbReference type="OMA" id="IVWLELP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01829">
        <property type="entry name" value="SGNH_hydrolase_peri2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF459"/>
    </dbReference>
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        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04311">
        <property type="entry name" value="DUF459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="406" mass="45990" checksum="DCE66BE0E8766EB2" modified="1998-11-01" version="1">MMTTVRVILQRCARGICSNKGRYSANQVLLFCILTLSLWTPFLGPALRHPAVYIRHKSVKNIYLAFVDPLMHTAEQWGIDTVFPLLRESFLHATGLIQHPEWEDTFYHCEQRSYEPAAALAESVPSPVLQEAVAVSPPGVAVNDSVAERKTTAPARVFSRTALRILMCGDSQMRYLTGGALQVLGTSSHVQIQEVTVSSSGFVRTDYYHWPRKFLALLDTHTQQEPYAAVIMAFGMNDYQNFYDADGSLCVTKTARWERAYEQKMRACLNIILHTVPKVYLLGMPETRNKQLNEKLVYIEHVQKKVVAQYDPQRVRYYSLKPIVPGVHGTYASAIRDTHGRWVHVMHKDGIHYTIEGGAYVMETLLPLILADLERSRHGYMRSSLGSHELPATKGMERARHASTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83580</accession>
    <name>O83580_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="123"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="281" mass="30970" checksum="A8A06E3C3F508706" modified="1998-11-01" version="1">MWFSLRRIGDLLSWLVGSKGVRGSFCADPVPRVDGAHGGDDPRREEDASGAFHIPRFAARLGLDSAGLLRIQRTVARVEGHTDGEVALALIKESDSYSVYELFFALVLAGACFCVQLSMVSVLEQAFARFFWAPPSWYMPAFMVASSVAACVLFFFIANIPWVDRALVPGPLKQQKSYARAVRHFVESGVCNTRNRTGILIFISVLERRVLVLADVGVSAYVPAREWTELCQIITAGLRSRRAADALCEALTRVEQVLATRMPPQKKSSNELPDGLVILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83599</accession>
    <name>O83599_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L36 (RpmJ-2)</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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            <taxon>Treponema</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="G71305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65565">
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        <property type="gene ID" value="TP_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0590"/>
    <dbReference type="HOGENOM" id="CLU_3334256_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
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    </dbReference>
    <dbReference type="GO" id="GO:0005840">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="38" mass="4357" checksum="70F59F4C035B8FF1" modified="1998-11-01" version="1">MQHMHRIIGQMIRTRGLKNVRCMAVEGKHNGRKNGARA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83611</accession>
    <name>O83611_TREPA</name>
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        <submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="D71304"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAC65575">
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        <property type="gene ID" value="TP_0602"/>
    </dbReference>
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        <property type="gene ID" value="TPANIC_0602"/>
    </dbReference>
    <dbReference type="GeneID" id="57879125"/>
    <dbReference type="KEGG" id="tpa:TP_0602"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.595"/>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_1_12"/>
    <dbReference type="OMA" id="FTFDEVG"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="49"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="111"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="287" mass="30867" checksum="426D08D3A0C1B0FB" modified="1998-11-01" version="1">MSAEIKRLLIFFFGVPTILMLVYAAPHAHFLAFHLVIFGSVMGAVWEMHAMVSRRMCTYPLVLLIPFSLVLPLLGYAALWQPARGAESVLFIGALGTLLMSVFFTELVYSFSASFENALERMASALLLVLYPGIFSLFFSLITRWRHAEIALVIFFLMVFTCDSCAWFCGTLWGVNNRGIIPASPKKSIAGFIGGFAGSVGAGCFGSLVFGSRVTLSLGMLMGVGALVGLTAIVGDLVESVMKRSAQVKDSGFFTPGRGGIMDNLDSLAPSLGTFYIACECFGIAAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83612</accession>
    <name>ISPT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoprenyl transferase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppS</name>
        <name type="ordered locus">TP_0603</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71304">
        <property type="entry name" value="E71304"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882049.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83612"/>
    <dbReference type="SMR" id="O83612"/>
    <dbReference type="IntAct" id="O83612">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0603"/>
    <dbReference type="PRIDE" id="O83612"/>
    <dbReference type="EnsemblBacteria" id="AAC65576">
        <property type="protein sequence ID" value="AAC65576"/>
        <property type="gene ID" value="TP_0603"/>
    </dbReference>
    <dbReference type="GeneID" id="57879126"/>
    <dbReference type="KEGG" id="tpa:TP_0603"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_12"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000123706" description="Isoprenyl transferase">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <sequence length="228" mass="26270" checksum="7FBDCDBB9AE37ACE" modified="1998-11-01" version="1">MQHVAIIMDGNGRWAERRGLRRSAGHRRGLQTAREIVAALCAIRVPFVTLYVFSTENWKRSAHEVHFLMNLIRWYLKKEMSFYVEHAIRVVHLGCAQTLPPDVRSQIEYVVERTRSHRGTTVALAINYGGKDEILRAVKKVLCSTSCPDGELLTEEAFGACLDAPQLPSVDFLIRTGGQQRMSNFLLWQSAYAEFYFTDILWPDFRVEDMLRALDEYRLRTRTFGGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83621</accession>
    <name>O83621_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SufBD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71303">
        <property type="entry name" value="A71303"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882058.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83621">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0612"/>
    <dbReference type="EnsemblBacteria" id="AAC65588">
        <property type="protein sequence ID" value="AAC65588"/>
        <property type="gene ID" value="TP_0612"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75793">
        <property type="protein sequence ID" value="AGN75793"/>
        <property type="gene ID" value="TPANIC_0612"/>
    </dbReference>
    <dbReference type="GeneID" id="57879135"/>
    <dbReference type="KEGG" id="tpa:TP_0612"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.604"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_12"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="151"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="479" mass="54106" checksum="17718D33CB04F247" modified="1998-11-01" version="1">MNTQQQRQLLQPRRRTYVSDIKRGIYDVKDAVTYTYSTGKGLNAQVVEKISRRKREPQWMLDLRLRSLRYFMKRPMPEWGADISDLDIQEIVHYIVSDFKPIAESWDDVPEEIKKTFDRLGIPEAERRSLAGVGAQYDSEVVYHNLRADLEQQGVVYLDMESAVHKHEDIVRAHFMHLIKPNEHKFAALHGAVWSGGSFVYVPKGVQVDLPLQSYFRLNANQSGQFEHTLIIVDEGASLHFIEGCSAPKYYKNALHAGAVELYVKKNARLRYSTIENWSRNLYNLNTKRAIVDEDGVIEWISGSFGSRVTMLYPMSILRGDRSRSEFTGITFASAGQYLDTGTKTVHLGRNTVSEVHARSISKNGGTANYRGLLSIGPKADGAKAVAECESLMLDNQSHTDTIPIIDVRTDNVDIGHEAKIGRISDRVVFYLMQRGLDEQTAISLIVRGFVEPVSKELPLEYAVELNNLISIELEGAIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83623</accession>
    <name>CSD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable cysteine desulfurase</fullName>
            <ecNumber>2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">csd</name>
        <name type="ordered locus">TP_0614</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71303">
        <property type="entry name" value="C71303"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882060.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83623"/>
    <dbReference type="SMR" id="O83623"/>
    <dbReference type="STRING" id="243276.TPANIC_0614"/>
    <dbReference type="EnsemblBacteria" id="AAC65590">
        <property type="protein sequence ID" value="AAC65590"/>
        <property type="gene ID" value="TP_0614"/>
    </dbReference>
    <dbReference type="GeneID" id="57879137"/>
    <dbReference type="KEGG" id="tpa:TP_0614"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_12"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000150320" description="Probable cysteine desulfurase">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="404" mass="43851" checksum="9F8464B473EA38FB" modified="1998-11-01" version="1">MSGPNYKADFPLLLRSPRVHYLDSAATTQRPAPVLERVMHYHTHLNGNAGRGSHELAVESALLIENTRKKTAQFINAAPTHDIVFTKSCTESLNIIAHCYALPRLRAGDEIVLAISNHHANIVPWQHVCRCTGATIQWLYPDAEGNLDIQEAQKKIRACTKIVSFSAVVNATGAVNPAQELTALAHQVGAVVVIDGAQAMVHGVPNVADLGCDFFVFSGHKMFSLFGVGVLCAPHTLLESMPPFLYGGGMVDFVTEQESVFKGAPHKYEGGSANTAAVVSLCAAIEYCESLESSAVRASVHALDAALLARLEELPFLETYHARARERLGIIAFNVKNVHSHDTAHILGEEGVMVRSGDHCSKPFMTHLSIQSCCRASFCIYNTMEDVEALTRALHAVGRIFQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O83636</accession>
    <name>O83636_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TP_0628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71302">
        <property type="entry name" value="E71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882074.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83636">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0628"/>
    <dbReference type="EnsemblBacteria" id="AAC65600">
        <property type="protein sequence ID" value="AAC65600"/>
        <property type="gene ID" value="TP_0628"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75809">
        <property type="protein sequence ID" value="AGN75809"/>
        <property type="gene ID" value="TPANIC_0628"/>
    </dbReference>
    <dbReference type="GeneID" id="57879151"/>
    <dbReference type="KEGG" id="tpa:TP_0628"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.620"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_2_1_12"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="376"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAC65600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="493" mass="54578" checksum="F59096FE91E5DB1F" modified="1998-11-01" version="1">MKTSALFLDFYELTMAQGYFFHKPHECAVFEVFFRKHPFAGGYSIFAGLDPLLTAIEQFRFSGEDIDYLRTLHLFHDDFLSYLASFRFSGDIHALEEGSVIFPHEPIIRVHARLVEALLLEGLILNTINFQSLIATKTARMWRASGEGVLMEFGLRRAQGYDGALSATRAAAIGGATGTSNTLAAKLYGIRPMGTMAHAWVMSFDSEEEAFERYAALYGSASVFLIDTYHTLESGIQNAIAIGTRLKAAGKSFGVRLDSGDMQYLSVQVRAALDAAGLPEARIAVSNELDETIIESLVLSGAPIDAWGVGTHLVTGGADSAFTGVYKMSARATTQPAHTQHGHAASQRLPHWDDAHWLPVMKVSDNPAKTTTPGIKQVWRLYDAAGQYKADVIGLADEVIEPQVAQRYIHPFYNLQSFTFAAHQVEPLLRTVMQAGNRLRAGESVQEIHARMRAQLQRLDKSYVRLLNPHVYKVSLTERLAQLKNTLITALRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O83639</accession>
    <name>CHEB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB</name>
        <name type="ordered locus">TP_0631</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71300">
        <property type="entry name" value="E71300"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882077.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83639"/>
    <dbReference type="SMR" id="O83639"/>
    <dbReference type="IntAct" id="O83639">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0631"/>
    <dbReference type="EnsemblBacteria" id="AAC65606">
        <property type="protein sequence ID" value="AAC65606"/>
        <property type="gene ID" value="TP_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0631"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_12"/>
    <dbReference type="OMA" id="MLEMHRA"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158035" description="Protein-glutamate methylesterase/protein-glutamine glutaminase">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="204"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="403" mass="44099" checksum="E629B147BF3AD03A" modified="1998-11-01" version="1">MKNTNDIAVLIVDDSALMRKVIGKVIEGAPGLSIAGKAMNGRFALDMLERVQPDVILLDLEMPHMNGLQFLEQRKRLRIDIPVIILSSIAKEGARVTMQCLELGASDFVTKPFGSESAHLRTVSRKIVDYVTAYGRRYKLLRRTRRCLAMDTPVERPAGEEDLNCLDTQERASLPSVCARAPARDRASYTITPTEGARQTRIVPLRESGALQIIAIGVSTGGPSALRHIFAQLDADLPQPVVVVQHMPAGFTREFAYSLNQVCALEVKEAQEGDLVRRGRVLIAPGDRHLTVERRSLATVAHINSDEPENGHRPSVDVLFESVARHFENRALGILMTGMGRDGAAQLARLYTEGSRTIAQDADSCIVYGMPRVACELGAVGEQVSLDDMAATINRYGKVFASS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83649</accession>
    <name>DPO3E_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase III subunit epsilon</fullName>
            <ecNumber>2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaQ</name>
        <name type="ordered locus">TP_0643</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations. Magnesium or manganese.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71299">
        <property type="entry name" value="B71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882088.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83649"/>
    <dbReference type="SMR" id="O83649"/>
    <dbReference type="IntAct" id="O83649">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0643"/>
    <dbReference type="EnsemblBacteria" id="AAC65617">
        <property type="protein sequence ID" value="AAC65617"/>
        <property type="gene ID" value="TP_0643"/>
    </dbReference>
    <dbReference type="GeneID" id="57879168"/>
    <dbReference type="KEGG" id="tpa:TP_0643"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_7_1_12"/>
    <dbReference type="OMA" id="FHVYLNP"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000105490" description="DNA polymerase III subunit epsilon">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <sequence length="215" mass="24239" checksum="DD91E08DA75756FF" modified="1998-11-01" version="1">MIYDWVFAVHEHVAFTAFDTETTGLKAEEDRIIEIGAVTFDRKGIIARFSTLIFPDRAIPPDVSKINHITDDMLVNKPRFCEIVSDFSRFIKGTVLVAHNANFDVEFLNAELSLCKKQPLSHKVVDTYAMAQAVFPGLGRHQYRLQNLALQFGLTVHAAHRAEDDARVCMELFTTMIAHHAKQNGHCVNHAQSPTIKKLIQEIQASSTDCSQELF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83675</accession>
    <name>DPO3A_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase III subunit alpha</fullName>
            <ecNumber>2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaE</name>
        <name type="ordered locus">TP_0669</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-C family. DnaE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71295">
        <property type="entry name" value="H71295"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882114.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83675"/>
    <dbReference type="SMR" id="O83675"/>
    <dbReference type="IntAct" id="O83675">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0669"/>
    <dbReference type="PRIDE" id="O83675"/>
    <dbReference type="EnsemblBacteria" id="AAC26567">
        <property type="protein sequence ID" value="AAC26567"/>
        <property type="gene ID" value="TP_0669"/>
    </dbReference>
    <dbReference type="GeneID" id="57879193"/>
    <dbReference type="KEGG" id="tpa:TP_0669"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_0_12"/>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000103356" description="DNA polymerase III subunit alpha">
        <location>
            <begin position="1"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1170" mass="132313" checksum="431FC4629FDE09F1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83678</accession>
    <name>SYG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQS</name>
        <name type="synonym">glyS</name>
        <name type="ordered locus">TP_0672</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71296">
        <property type="entry name" value="C71296"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83678"/>
    <dbReference type="SMR" id="O83678"/>
    <dbReference type="STRING" id="243276.TPANIC_0672"/>
    <dbReference type="EnsemblBacteria" id="AAC26570">
        <property type="protein sequence ID" value="AAC26570"/>
        <property type="gene ID" value="TP_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0672"/>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_12"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072986" description="Glycine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="185"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <sequence length="462" mass="52677" checksum="D2E52E16B9CA61BE" modified="1998-11-01" version="1">MEKIVGLCKRRGFVFPSSEIYGGQGGVWDYGPMGIALKNNIAHAWWQDMTRLHDHIVGLDAAILMHPNVWRTSGHVDHFSDPLVDCTVCKSRFRADQVAVPSAGGPCPQCGGALTGVRNFNLMFSTHMGPTDERASLLYLRPETAQGIYVNYKNVLQTTRLKVPFGIAQIGKAFRNEIVTKNFIFRTCEFEQMEMQFFVRPAEDTHWFEYWCAQRWAFYQKYGVRMNHMRWRTHAAHELAHYARAACDIEYAFPMGFRELEGVHNRGDFDLTRHAQHSGKDLCYVDPDPNLDAAARRYVPCVVETSAGLTRCVLMFLCDAYTEEYVQAPNVAFSETTQTADQEGAARTGEMRIVLRLHPALSPTTVAFLPLVKKDGLVDLARAVRDELREDFACDFDAAGAIGKRYRRQDEVGTPFCVTVDYQSKEDDTVTVRLRDSMAQRRVSRAFLAEFLRTEIKHYRRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83682</accession>
    <name>Y676_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0676</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0676</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71294">
        <property type="entry name" value="D71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882121.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83682"/>
    <dbReference type="SMR" id="O83682"/>
    <dbReference type="IntAct" id="O83682">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0676"/>
    <dbReference type="EnsemblBacteria" id="AAC65652">
        <property type="protein sequence ID" value="AAC65652"/>
        <property type="gene ID" value="TP_0676"/>
    </dbReference>
    <dbReference type="GeneID" id="57879200"/>
    <dbReference type="KEGG" id="tpa:TP_0676"/>
    <dbReference type="HOGENOM" id="CLU_2412293_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202301" description="Uncharacterized protein TP_0676">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="92" mass="10266" checksum="888130AB4EB8F682" modified="1998-11-01" version="1">MRCSHNWDDPPPLFGAVSYGMQEGAGRGVRREARDTPCRGTAEGLATSQPEDGETRAALQRIDHLDTQLLQLERDLAHYLEMAELPDPFSEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83683</accession>
    <name>Y677_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0677</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0677</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71294">
        <property type="entry name" value="E71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882122.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83683"/>
    <dbReference type="SMR" id="O83683"/>
    <dbReference type="IntAct" id="O83683">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0677"/>
    <dbReference type="EnsemblBacteria" id="AAC65653">
        <property type="protein sequence ID" value="AAC65653"/>
        <property type="gene ID" value="TP_0677"/>
    </dbReference>
    <dbReference type="GeneID" id="57879201"/>
    <dbReference type="KEGG" id="tpa:TP_0677"/>
    <dbReference type="eggNOG" id="ENOG50348SD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389676_0_0_12"/>
    <dbReference type="OMA" id="MSAKEND"/>
    <dbReference type="OrthoDB" id="1216113at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202302" description="Uncharacterized protein TP_0677">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <sequence length="202" mass="21755" checksum="95C657AD9854DB6A" modified="1998-11-01" version="1">MQYSGPMQEEVSERTCLVSDPSLSSVAGAGSGVVQAYVARQLARQVHACVDCGMRGIRRAVRRFAADVIAREAPELTAAKREALLDAWVPSPSSEHVAVGSQPAQACGGAPLPADVQYSMVLHFVWYGLGVLSEQERVQLEQAVPHWPQVYWSCFSPQLKRLIKACLTGLLDVEAFCAAVRTLLGIAGMDTAADASIHPHEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83684</accession>
    <name>Y678_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0678</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0678</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To B.burgdorferi BB0340.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71294">
        <property type="entry name" value="F71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882123.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83684"/>
    <dbReference type="IntAct" id="O83684">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0678"/>
    <dbReference type="EnsemblBacteria" id="AAC65654">
        <property type="protein sequence ID" value="AAC65654"/>
        <property type="gene ID" value="TP_0678"/>
    </dbReference>
    <dbReference type="GeneID" id="57879203"/>
    <dbReference type="KEGG" id="tpa:TP_0678"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082735_0_0_12"/>
    <dbReference type="OMA" id="PWEKEEG"/>
    <dbReference type="OrthoDB" id="1857059at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202303" description="Uncharacterized protein TP_0678">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="307" mass="34764" checksum="7D056274138E3D8E" modified="1998-11-01" version="1">MEAYQAEIIRRFGRVRRARGFYLYTERGVRITDLFLDGGASILGRNASRARLDFKRYLSRGLWGPLPTCASAQLQQALRTCFPAHEVRYYAHAERAQEVCARFLNLACGAAPCEVPVWRPCAPCVPQTDVFLVVPPFPSPAPFVALRAHCAARAPAGDVLFAPIAQAIARAFWDLARVGSLSQPARAMPHALLDSSHTTQEDAVPALPHTKKRRRGLNRVRRAQKCARQERDRAQLITLMSTWWRTEGPYLFPTVSEERYEALFARALDAHILLSPLYTEPSVLPTLEHYTQLCTFFLQEQEKEHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83708</accession>
    <name>O83708_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jag_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71290">
        <property type="entry name" value="B71290"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882155.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0710"/>
    <dbReference type="EnsemblBacteria" id="AAC65676">
        <property type="protein sequence ID" value="AAC65676"/>
        <property type="gene ID" value="TP_0710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75885">
        <property type="protein sequence ID" value="AGN75885"/>
        <property type="gene ID" value="TPANIC_0710"/>
    </dbReference>
    <dbReference type="GeneID" id="57879235"/>
    <dbReference type="KEGG" id="tpa:TP_0710"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.700"/>
    <dbReference type="eggNOG" id="COG1315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026157_1_0_12"/>
    <dbReference type="OMA" id="TGHVKFK"/>
    <dbReference type="OrthoDB" id="379544at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jag_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="656" mass="72023" checksum="3D2E35B49F5E7569" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83709</accession>
    <name>Y711_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0711</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0711</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">To B.burgdorferi BB0265.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71290">
        <property type="entry name" value="C71290"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882156.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83709"/>
    <dbReference type="IntAct" id="O83709">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0711"/>
    <dbReference type="EnsemblBacteria" id="AAC65677">
        <property type="protein sequence ID" value="AAC65677"/>
        <property type="gene ID" value="TP_0711"/>
    </dbReference>
    <dbReference type="GeneID" id="57879236"/>
    <dbReference type="KEGG" id="tpa:TP_0711"/>
    <dbReference type="eggNOG" id="ENOG5032NXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122426_0_0_12"/>
    <dbReference type="OMA" id="FFNILMW"/>
    <dbReference type="OrthoDB" id="1573401at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202310" description="Uncharacterized protein TP_0711">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="190" mass="21267" checksum="117CE4A992AD58EB" modified="1998-11-01" version="1">MLVMSITFSFVAVALLVYFYVKVRTSFSPDAYAKTMQQEVIKMIRDIRYEADIAVQMLEKKIGECNQVVRTIDRKLTLLNEEILKEHTARTLFRASGAGQETREEVCARPEHRSAPSRAGSSAAKPTPTKRGTIEVYNEKIIRDNGLRAESPLLKDAIIALSEKGLAPEFIAEKTGKPLGEVQLLINLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83713</accession>
    <name>O83713_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71287">
        <property type="entry name" value="H71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882176.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0731"/>
    <dbReference type="EnsemblBacteria" id="AAC65700">
        <property type="protein sequence ID" value="AAC65700"/>
        <property type="gene ID" value="TP_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0731"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.776"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_8_2_12"/>
    <dbReference type="OMA" id="IFVRQYR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="236" mass="27119" checksum="86B2BDD568B45EE4" modified="1998-11-01" version="1">MPCNTQNLYQPGQKECTPMDEGRETVQPAHRAKEEKKQDAHLAWEVRKRHEACRLRVFHVQELESVSPRKTVRRFVTLTAPEWVIVVPHVMERAQRFFVMVRQWRCGSQTVCTEFPGGVIDAGEHPEAAARRELFEETGRRASSLAHLGTIHPNPAVLENRVHIFSAECTPEVREPQLDTDEFLERCVLPVHDVYERMGRAPFDHALMAQPSFFFCGRIRFPPCNSVRYVACSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83721</accession>
    <name>O83721_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71288">
        <property type="entry name" value="H71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882184.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83721">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0739"/>
    <dbReference type="EnsemblBacteria" id="AAC65707">
        <property type="protein sequence ID" value="AAC65707"/>
        <property type="gene ID" value="TP_0739"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75913">
        <property type="protein sequence ID" value="AGN75913"/>
        <property type="gene ID" value="TPANIC_0739"/>
    </dbReference>
    <dbReference type="GeneID" id="57879263"/>
    <dbReference type="KEGG" id="tpa:TP_0739"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.728"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690662_0_0_12"/>
    <dbReference type="OMA" id="HEPDYYI"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="93"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="299"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="398" mass="44211" checksum="867B6CF75167E2A3" modified="1998-11-01" version="1">MKVLDMGRHGLFLLLIFFMLVITVFAVFFGMKRDPLESSLSSDNILKVLFVIEHENVPISSNVVAYYPATRRAAMFDIPHNMGLILQSLGRTDGIGSLYSERGIEEYKREVEKLTGINVPFSVVCSLDNFSKLTDLLSGLSVFIPTPIDVHTERAGHVLLPSGSVSLDGDKMRDYLLYEDEDEGEGESASRKQKAILALLRSVNDHSEFFVHSTRAFSLNRLIRSNVRRADLKKLIGELSKLDSERLVPQRFSGTKRVVDGKVLLFPSRDGQQIKEIVRQTLAVLASENGTAFERVYALEILNGTESHGLARTTANIYQGFGYDVVRVDNALEQSVQKTVLVDRIGNPAVAKVVAQVIRCQNIETTSASLDEYGVETGIDFTLILGKDFNGYLVKEGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83732</accession>
    <name>Y751_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0751</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0751</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71287">
        <property type="entry name" value="D71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882196.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="5JK2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I=78-237"/>
    </dbReference>
    <dbReference type="PDBsum" id="5JK2"/>
    <dbReference type="AlphaFoldDB" id="O83732"/>
    <dbReference type="SMR" id="O83732"/>
    <dbReference type="IntAct" id="O83732">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0751"/>
    <dbReference type="EnsemblBacteria" id="AAC65720">
        <property type="protein sequence ID" value="AAC65720"/>
        <property type="gene ID" value="TP_0751"/>
    </dbReference>
    <dbReference type="GeneID" id="57879274"/>
    <dbReference type="KEGG" id="tpa:TP_0751"/>
    <dbReference type="HOGENOM" id="CLU_1170245_0_0_12"/>
    <dbReference type="OMA" id="MRIALWS"/>
    <dbReference type="OrthoDB" id="1165843at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041037">
        <property type="entry name" value="Pallilysin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18663">
        <property type="entry name" value="Pallilysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014257" description="Uncharacterized protein TP_0751">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="151"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="5JK2"/>
        </source>
    </evidence>
    <sequence length="237" mass="25769" checksum="447FEBD7D380E852" modified="1998-11-01" version="1" precursor="true">MNRPLLSVAGSLFVAAWALYIFSCFQHGHVPPRRIPPHDTFGALPTAALPSNARDTAAHPSDTADNTSGSSTTTDPRSHGNAPPAPVGGAAQTHTQPPVQTAMRIALWNRATHGEQGALQHLLAGLWIQTEISPNSGDIHPLLFFDREHAEITFSRASVQEIFLVDSAHTHRKTVSFLTRNTAISSIRRRLEVTFESHEVIHVRAVEDVARLKIGSTSMWDGQYTRYHAGPASAPSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83746</accession>
    <name>FTSH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsH</name>
        <name type="ordered locus">TP_0765</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71285">
        <property type="entry name" value="H71285"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83746"/>
    <dbReference type="SMR" id="O83746"/>
    <dbReference type="IntAct" id="O83746">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0765"/>
    <dbReference type="EnsemblBacteria" id="AAC65728">
        <property type="protein sequence ID" value="AAC65728"/>
        <property type="gene ID" value="TP_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0765"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_12"/>
    <dbReference type="OMA" id="YDKQGGG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000084656" description="ATP-dependent zinc metalloprotease FtsH">
        <location>
            <begin position="1"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="107"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="609" mass="67544" checksum="0AE932C2A4F6A5D4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83747</accession>
    <name>Y766_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0766</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0766</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71283">
        <property type="entry name" value="C71283"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882211.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83747"/>
    <dbReference type="IntAct" id="O83747">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65741">
        <property type="protein sequence ID" value="AAC65741"/>
        <property type="gene ID" value="TP_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0766"/>
    <dbReference type="eggNOG" id="ENOG5031CPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949773_0_0_12"/>
    <dbReference type="OMA" id="IRYRAGH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202319" description="Uncharacterized protein TP_0766">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <sequence length="293" mass="32877" checksum="F2091561B76AB196" modified="1998-11-01" version="1">MTPTYHPYPGDNRPFLYAALQRREHLSLIRYRAEHAQDLAPLRAFLARIEAHATVIGARTRGDTLFILAASMPSDALRDEKHAYVRTISWEQAPQILETLERPPLPPYCPPVPTSCSSSRLIPDVPHNTRSHAQESSYTSRHALLTLLIEWRALMVEMDYSVRAHRVQRSSAPLHERHGTLPSDVLLFQTQGEVCALCAFQLQHVRAVGGQRHLIIHEAAGGGNIACERIFSLKEIDFATAKFTERIRRGLYQVAVHTAHADFTVNLIVPSLREQGGAYSLAESSAFHRRVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83757</accession>
    <name>O83757_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG protein (MazG)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71282">
        <property type="entry name" value="C71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882223.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83757">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0778"/>
    <dbReference type="EnsemblBacteria" id="AAC65746">
        <property type="protein sequence ID" value="AAC65746"/>
        <property type="gene ID" value="TP_0778"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75951">
        <property type="protein sequence ID" value="AGN75951"/>
        <property type="gene ID" value="TPANIC_0778"/>
    </dbReference>
    <dbReference type="GeneID" id="57879300"/>
    <dbReference type="KEGG" id="tpa:TP_0778"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.765"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_12"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="303" mass="34016" checksum="C7E62AAD9D769337" modified="1998-11-01" version="1">MMSTCAQAFYRLYEIIVRLRAPDGCAWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHSSYAHVQEELGDVLMNVCMIAYMYEQRGVFSLADVVTALTEKLIRRHPHVFGQTEGFPGPENPKRAQTAQEVFDQWERIKTQVERRRAASPLEGIPRTVPPLMRASKMQKNASRARLFCPTRTEVVRECARTFRALRAMSENSAEQSATQAAHVAVGALLTAVISFAHLVGVDPVLALIRANADFVRRFSCACSIPAISGGTSVFLSRACHKPRRARTRASAVRRRARSRRLFFTRHKLGNMLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83771</accession>
    <name>Y793_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0793</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0793</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71280">
        <property type="entry name" value="H71280"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882238.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83771"/>
    <dbReference type="IntAct" id="O83771">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0793"/>
    <dbReference type="EnsemblBacteria" id="AAC65766">
        <property type="protein sequence ID" value="AAC65766"/>
        <property type="gene ID" value="TP_0793"/>
    </dbReference>
    <dbReference type="GeneID" id="57879314"/>
    <dbReference type="KEGG" id="tpa:TP_0793"/>
    <dbReference type="eggNOG" id="ENOG5030P3E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494258_0_0_12"/>
    <dbReference type="OMA" id="LASEKEW"/>
    <dbReference type="OrthoDB" id="676563at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202327" description="Uncharacterized protein TP_0793">
        <location>
            <begin position="1"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="539" mass="63114" checksum="903A2D57F0DAED44" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83773</accession>
    <name>Y795_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0795</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0795</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71281">
        <property type="entry name" value="B71281"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83773"/>
    <dbReference type="SMR" id="O83773"/>
    <dbReference type="IntAct" id="O83773">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65767">
        <property type="protein sequence ID" value="AAC65767"/>
        <property type="gene ID" value="TP_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0795"/>
    <dbReference type="HOGENOM" id="CLU_3085909_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202328" description="Uncharacterized protein TP_0795">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <sequence length="52" mass="5770" checksum="5654464CADB69233" modified="1998-11-01" version="1">MHSTPLVSAALIFAYTLTSDRTPAHASCTHTMMRTVRHTFLHTNSTRAVLTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83774</accession>
    <name>APBE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="1">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">apbE</name>
        <name type="ordered locus">TP_0796</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Biol. Chem." volume="288" first="11106" last="11121">
            <title>The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Liu W.Z."/>
                <person name="Tomchick D.R."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="23447540"/>
            <dbReference type="DOI" id="10.1074/jbc.M113.449975"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 23-362 IN COMPLEXES WITH ADP; AMP; FAD AND MAGNESIUM</scope>
        <scope>FUNCTION</scope>
        <scope>COFACTOR</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein (By similarity). Displays FAD pyrophosphatase activity in vitro, hydrolyzing FAD into FMN and AMP (PubMed:23447540).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cell inner membrane</location>
            <topology evidence="2 3">Lipid-anchor</topology>
            <orientation evidence="2">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71281">
        <property type="entry name" value="C71281"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882241.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="PDB" id="4IFU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.83 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4IFW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4IFX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.45 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4IFZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4IG1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.43 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4XDR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4XDT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.45 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDB" id="4XDU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.35 A"/>
        <property type="chains" value="A=23-362"/>
    </dbReference>
    <dbReference type="PDBsum" id="4IFU"/>
    <dbReference type="PDBsum" id="4IFW"/>
    <dbReference type="PDBsum" id="4IFX"/>
    <dbReference type="PDBsum" id="4IFZ"/>
    <dbReference type="PDBsum" id="4IG1"/>
    <dbReference type="PDBsum" id="4XDR"/>
    <dbReference type="PDBsum" id="4XDT"/>
    <dbReference type="PDBsum" id="4XDU"/>
    <dbReference type="SMR" id="O83774"/>
    <dbReference type="STRING" id="243276.TPANIC_0796"/>
    <dbReference type="EnsemblBacteria" id="AAC65759">
        <property type="protein sequence ID" value="AAC65759"/>
        <property type="gene ID" value="TP_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0796"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_0_12"/>
    <dbReference type="OMA" id="MGTFWRV"/>
    <dbReference type="BRENDA" id="2.7.1.180">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="BRENDA" id="3.6.1.18">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000001751" description="FAD:protein FMN transferase">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="30"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="strand" evidence="7">
        <location>
            <begin position="41"/>
            <end position="49"/>
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</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>O83779</accession>
    <name>O83779_TREPA</name>
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        <submittedName>
            <fullName evidence="9">ATP-dependent Clp protease subunit A (ClpA)</fullName>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
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            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
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        <source>
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    <sequence length="809" mass="89328" checksum="D9C8CBEE250CAEEE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83785</accession>
    <name>RL32_TREPA</name>
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        <recommendedName>
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    </protein>
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        <lineage>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
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            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
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        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
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    <dbReference type="KEGG" id="tpa:TP_0807"/>
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    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000172429" description="50S ribosomal protein L32">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="62" mass="7045" checksum="57299DB41E909294" modified="2007-01-23" version="3">MAVPRANTSKARTRRRRAVNMRLEAPHLVECGNCGNFVQSHRVCGRCGFYRGRQVINPDDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83812</accession>
    <name>O83812_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71275">
        <property type="entry name" value="E71275"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882284.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83812">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0840"/>
    <dbReference type="EnsemblBacteria" id="AAC65806">
        <property type="protein sequence ID" value="AAC65806"/>
        <property type="gene ID" value="TP_0840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76010">
        <property type="protein sequence ID" value="AGN76010"/>
        <property type="gene ID" value="TPANIC_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0840"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.827"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371281_0_0_12"/>
    <dbReference type="OMA" id="IAWILMG"/>
    <dbReference type="OrthoDB" id="907010at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="749" mass="82281" checksum="26E4B505D30BCE25" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83826</accession>
    <name>O83826_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71274">
        <property type="entry name" value="F71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882298.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0854"/>
    <dbReference type="EnsemblBacteria" id="AAC65822">
        <property type="protein sequence ID" value="AAC65822"/>
        <property type="gene ID" value="TP_0854"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76024">
        <property type="protein sequence ID" value="AGN76024"/>
        <property type="gene ID" value="TPANIC_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0854"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.905"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243603_0_0_12"/>
    <dbReference type="OMA" id="GKEVQKM"/>
    <dbReference type="OrthoDB" id="15371at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697228" description="HAMP domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="858"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="1533" mass="172871" checksum="2B077356F059EAD0" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83830</accession>
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    <protein>
        <recommendedName>
            <fullName>UPF0164 protein TP_0858</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0858</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
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        <lineage>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
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                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
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                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
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            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0164 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65829" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65829.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71272">
        <property type="entry name" value="B71272"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83830"/>
    <dbReference type="IntAct" id="O83830">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0858"/>
    <dbReference type="EnsemblBacteria" id="AAC65829">
        <property type="protein sequence ID" value="AAC65829"/>
        <property type="gene ID" value="TP_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0858"/>
    <dbReference type="HOGENOM" id="CLU_060535_0_0_12"/>
    <dbReference type="OMA" id="RACITMG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005362">
        <property type="entry name" value="UPF0164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03687">
        <property type="entry name" value="UPF0164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000036218" description="UPF0164 protein TP_0858">
        <location>
            <begin position="29"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="396" mass="42063" checksum="C4BD48F81374DBFF" modified="2001-06-01" version="2" precursor="true">MGTMIRHTFTHRCGALLCALALGSSTMAATAAAKPKKGQMQKLRQRPVWAPTGGRYASLDGAFTALANDASFFEANPAGSANMTHGELAFFHTTGFGSFHAETLSYVGQSGNWGYGASMRMFFPESGFDFSTTTEPVCTPASNPIKQRGAIGIINFARRIGGLSLGANLKAGFRDAQGLQHTSVSSDIGLQWVGNVAKSFTSEEPNLYIGLAATNLGLTVKVSDKIENCTSTCEKCGCCKERCCCNGKKACCKDCDCNCPCQDCNDKGTVHATDTMLRAGFAYRPFSWFLFSLGATTSMNVQTLASSDAKSLYQNLAYSIGAMFDPFSFLSLSSSFRINHKANMRVGVGAEARIARIKLNAGYRCDVSDISSGSGCTGAKASHYLSLGGAILLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83835</accession>
    <name>O83835_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen fixation protein (NifS-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71272">
        <property type="entry name" value="G71272"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882307.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83835"/>
    <dbReference type="STRING" id="243276.TPANIC_0863"/>
    <dbReference type="EnsemblBacteria" id="AAC65826">
        <property type="protein sequence ID" value="AAC65826"/>
        <property type="gene ID" value="TP_0863"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76032">
        <property type="protein sequence ID" value="AGN76032"/>
        <property type="gene ID" value="TPANIC_0863"/>
    </dbReference>
    <dbReference type="GeneID" id="57879378"/>
    <dbReference type="KEGG" id="tpa:TP_0863"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.848"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_12"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="320"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="427" mass="45733" checksum="0B5247CDBFA901AD" modified="1998-11-01" version="1">MNLYLDWAAAAIPETRLILRETQQACTLFANPSAVHCLGNDARDALERARHTCAQSLGINPERLIFTSGGSEANQLALLSVLTRLPHAEISVSMLEHASVTALLPRLERLQVSVRHIPVNARGFITPEAVRATLSPRTTLVCVSAVHSETGAIQPLPAIAHVLAHTGTRGRSIQLHVDAAQAFGKIPLNLYMDLPRIEEHAQENNAPQTPPGYPAPTAQRALTYSVAISGHKIGAPRGIGLLCAHRSFTPFVLGGGQEKERRPGTENLAGALALAACVREGAFFRTLHTTPEGPTPHTKPTAPAGLRSVRARTCAFVRALSDLPRVQLVPATRKEDEAHFSPYIVCCAVQDASGEALVRAFSDAGVCISTGSACSTKKGGVSTRLLRALGVESRATRGVLRFSFGPHTTAEDLDRVLTLFRTLLQKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83859</accession>
    <name>TRUB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">TP_0889</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71269">
        <property type="entry name" value="F71269"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882332.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83859"/>
    <dbReference type="SMR" id="O83859"/>
    <dbReference type="IntAct" id="O83859">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0889"/>
    <dbReference type="EnsemblBacteria" id="AAC26579">
        <property type="protein sequence ID" value="AAC26579"/>
        <property type="gene ID" value="TP_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0889"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_12"/>
    <dbReference type="OMA" id="VELTHAE"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000121934" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="366" mass="39471" checksum="0F57E62004426E7D" modified="1998-11-01" version="1">MCRLSMPDAIVPFAKVSGLTSFAALAQVRRLLGVKKVGHTGTLDRFADGLLLLLVGGFTKLAPVMTRLEKSYEARIQFGVQTDTLDPEGAVVRCSLFPTFARVRAALPHFTGSIDQVPPEYSALKFGGVRASDRVRRGEAVCMKARRVFVFDLQVLGCEADLGEFKKTQAGRGAAIADLDLTRVRAVTLYVRCSAGFYVRALARDIAAACGSCAYVSHLRRTRIGPFDLAQAAGVSRLGSWTWGKERASCGAACFDVGAPPPPSSGGVATDSVSFGCEDLTVREIKQAVVSCDVDFANRIGLTACSVHAQYASRFLHGERIRACWFQSFGTRRPGERALVFSEGRCLGLIRKAANGFSYDAVFCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83872</accession>
    <name>O83872_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylesterase (Est)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71267">
        <property type="entry name" value="C71267"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882345.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83872">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0902"/>
    <dbReference type="ESTHER" id="trepa-TP0902">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.946"/>
    <dbReference type="EnsemblBacteria" id="AAC65855">
        <property type="protein sequence ID" value="AAC65855"/>
        <property type="gene ID" value="TP_0902"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76070">
        <property type="protein sequence ID" value="AGN76070"/>
        <property type="gene ID" value="TPANIC_0902"/>
    </dbReference>
    <dbReference type="GeneID" id="57879413"/>
    <dbReference type="KEGG" id="tpa:TP_0902"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.886"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076594_0_0_12"/>
    <dbReference type="OMA" id="DWYAEVD"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="65"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="293" mass="32926" checksum="EE3D18C28786FE9F" modified="1998-11-01" version="1">MRPIVAAQRVTIQETRAVLAARFLFTFCCFFTTLARYLLMAEHTSCTSIHPLVRSAFYAGGAHAVLLIHGYMGTPREMQFLGRALHRDGFTVSIPRLPGHGTNREDFLETGWRDWLRRVCDEYRDLSAAYPSVSVGGLSMGGVLTALVAARFCPQKAFFCAPGFAVSDWRIKLSPLVRWFVREFAADAAPFYPEQDFNDATKDYRSAHYIAQVAQFYALQRRAIRSLACIRSTLLTILSRQDPLVPCAAVQKLLDARVRSAHQYVVLEHSGHVITDDVEREQVASCVSAFLRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83875</accession>
    <name>RS16_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">TP_0905</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71267">
        <property type="entry name" value="F71267"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882348.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83875"/>
    <dbReference type="SMR" id="O83875"/>
    <dbReference type="IntAct" id="O83875">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0905"/>
    <dbReference type="EnsemblBacteria" id="AAC65857">
        <property type="protein sequence ID" value="AAC65857"/>
        <property type="gene ID" value="TP_0905"/>
    </dbReference>
    <dbReference type="GeneID" id="57879415"/>
    <dbReference type="KEGG" id="tpa:TP_0905"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_3_1_12"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000167274" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="123" mass="13612" checksum="6E2E9B09B21E0FB8" modified="1998-11-01" version="1">MSLRIRLKKLGSKKRPYYRIVVQDAREPRDGRAIEELGIYQPIAPKGTEVSFRLDRARFWLERGAQPSDTVRRLLQSRRGSVLNAVASDERRVASSQQAADLAHVESVSCAAPIPSSPGGQGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83877</accession>
    <name>RIMM_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name type="ordered locus">TP_0907</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71267">
        <property type="entry name" value="H71267"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83877"/>
    <dbReference type="SMR" id="O83877"/>
    <dbReference type="IntAct" id="O83877">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0907"/>
    <dbReference type="EnsemblBacteria" id="AAC65859">
        <property type="protein sequence ID" value="AAC65859"/>
        <property type="gene ID" value="TP_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0907"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_2_12"/>
    <dbReference type="OMA" id="MFVKGII"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000163383" description="Ribosome maturation factor RimM">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PRC barrel" evidence="1">
        <location>
            <begin position="101"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <sequence length="174" mass="18945" checksum="18C1035766D5EC26" modified="1998-11-01" version="1">MTARIVSTFGVAGLLRLKSFSGEYAHLATLKQVCLAPPRSRSSGTLACALPREAVHMVEHVLLRAQDALLKLHRVDTVECARTFVGAELRVPRAEACPLSAGEFYLADLCRCELVFEGSAVGVVLSVVEGGGSSLLEVQRTHGGVCYVPFHRTFIGDVDVGRKKIELLQRWILE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83894</accession>
    <name>O83894_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tex protein (Tex)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71263">
        <property type="entry name" value="E71263"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882367.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83894">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0924"/>
    <dbReference type="EnsemblBacteria" id="AAC65881">
        <property type="protein sequence ID" value="AAC65881"/>
        <property type="gene ID" value="TP_0924"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76091">
        <property type="protein sequence ID" value="AGN76091"/>
        <property type="gene ID" value="TPANIC_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0924"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.976"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_12"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="646"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="778" mass="85203" checksum="2C219E3E1565EF7E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83895</accession>
    <name>FLAV_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fldA</name>
        <name type="ordered locus">TP_0925</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71263">
        <property type="entry name" value="F71263"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882368.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83895"/>
    <dbReference type="SMR" id="O83895"/>
    <dbReference type="IntAct" id="O83895">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0925"/>
    <dbReference type="EnsemblBacteria" id="AAC65882">
        <property type="protein sequence ID" value="AAC65882"/>
        <property type="gene ID" value="TP_0925"/>
    </dbReference>
    <dbReference type="GeneID" id="57879437"/>
    <dbReference type="KEGG" id="tpa:TP_0925"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_4_3_12"/>
    <dbReference type="OMA" id="FGSYDWG"/>
    <dbReference type="OrthoDB" id="1961680at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000171646" description="Flavodoxin">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="146" mass="15793" checksum="398A7D7C8530F2CE" modified="1998-11-01" version="1">MAKVAVIFWSGTGHTETMARCIVEGLNVGGAKADLFSVMDFDVGTFDSYDRFAFGCSAAGSEELESSEFEPFFTSIEGRLSGKKVALFGSYEWAGEGEGGEWMVNWVERCKAAGADVFEGKGEIAYDDPSEEAQASCKAFGERFAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83899</accession>
    <name>Y929_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0929</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0929</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71264">
        <property type="entry name" value="B71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882372.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83899"/>
    <dbReference type="IntAct" id="O83899">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0928"/>
    <dbReference type="EnsemblBacteria" id="AAC65888">
        <property type="protein sequence ID" value="AAC65888"/>
        <property type="gene ID" value="TP_0929"/>
    </dbReference>
    <dbReference type="GeneID" id="62675419"/>
    <dbReference type="KEGG" id="tpa:TP_0929"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085619_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202355" description="Uncharacterized protein TP_0929">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <sequence length="256" mass="28193" checksum="0CB0FB7874828BFA" modified="1998-11-01" version="1">MSFEDAVATGSTKVGTDATGKMTHSYRSDVNEFFPDAQDLDTVLRTAVGALSPVVKIERGFAIVRTDAEPSAPDFSDAATRERVFAHMARVERGTIERFLEEEAHTFSTRAKQGGFTAAAQSLNLDVHTSRSFPINFGNVDVLPALPRQSDPPLARIAYDEKFFSTAFALLPGQVSDPLILDSSVVLLQLHEEKSVDESVLATTGDSYAHHVRTWYPGYPLALLNTAKMPWAQESVVDTILAHPSFKDTFDNIFRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83900</accession>
    <name>Y930_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0930</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0930</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71264">
        <property type="entry name" value="C71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882373.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83900"/>
    <dbReference type="STRING" id="243276.TPANIC_0930"/>
    <dbReference type="PRIDE" id="O83900"/>
    <dbReference type="EnsemblBacteria" id="AAC65889">
        <property type="protein sequence ID" value="AAC65889"/>
        <property type="gene ID" value="TP_0930"/>
    </dbReference>
    <dbReference type="GeneID" id="57879441"/>
    <dbReference type="KEGG" id="tpa:TP_0930"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033812_0_0_12"/>
    <dbReference type="OMA" id="YLWAHFP"/>
    <dbReference type="OrthoDB" id="1153411at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202356" description="Uncharacterized protein TP_0930">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <sequence length="573" mass="64724" checksum="4A085F7C7B612E6A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83907</accession>
    <name>O83907_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71262">
        <property type="entry name" value="E71262"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882380.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83907">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0937"/>
    <dbReference type="EnsemblBacteria" id="AAC65894">
        <property type="protein sequence ID" value="AAC65894"/>
        <property type="gene ID" value="TP_0937"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76102">
        <property type="protein sequence ID" value="AGN76102"/>
        <property type="gene ID" value="TPANIC_0937"/>
    </dbReference>
    <dbReference type="GeneID" id="57879448"/>
    <dbReference type="KEGG" id="tpa:TP_0937"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.920"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_2_1_12"/>
    <dbReference type="OMA" id="KELMECM"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="211" mass="22799" checksum="C77270F8FDF9E9BE" modified="1998-11-01" version="1">MNTLEMTAPGVIGGRESIASLHMLSCARLLLVSDTHGSAEALTAVVDQFGSCADALLFAGDGIGDVLYLCQRGRRNRVLRERIPGVIFMVAGNCDRASHIPLCGRIQVADVTLFLAHGHTHSVNVSDSVLVSQALQACCSIAVHGHTHVQRACVSSRVLIINPGSLEHARGSSHAGFALLHVMNSAHTRTVFYRTRRQGHRYLFEETVPRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83925</accession>
    <name>Y959_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0959</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0959</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71259">
        <property type="entry name" value="B71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882403.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83925"/>
    <dbReference type="IntAct" id="O83925">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0959"/>
    <dbReference type="EnsemblBacteria" id="AAC65923">
        <property type="protein sequence ID" value="AAC65923"/>
        <property type="gene ID" value="TP_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0959"/>
    <dbReference type="eggNOG" id="COG3951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969552_0_0_12"/>
    <dbReference type="OrthoDB" id="1913134at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202364" description="Uncharacterized protein TP_0959">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <sequence length="129" mass="13903" checksum="40433B5418765690" modified="1998-11-01" version="1">MNVHRVLSLGMQSVPSVTLSKTGKMEGSGSFAARLSAAQQGAACSAEKNDALYTQARELETLFVRVMVQSMRETLSGQTLAGERSFSGRLYEDALYEHFSAQLAAQGGFGLAEKVYRQLNPRREAAPGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83938</accession>
    <name>SYFA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">TP_0973</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71257">
        <property type="entry name" value="C71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882417.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83938"/>
    <dbReference type="SMR" id="O83938"/>
    <dbReference type="IntAct" id="O83938">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0973"/>
    <dbReference type="EnsemblBacteria" id="AAC65930">
        <property type="protein sequence ID" value="AAC65930"/>
        <property type="gene ID" value="TP_0973"/>
    </dbReference>
    <dbReference type="GeneID" id="57879482"/>
    <dbReference type="KEGG" id="tpa:TP_0973"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_12"/>
    <dbReference type="OMA" id="VHIKHPV"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00282">
        <property type="entry name" value="Phe_tRNA_synth_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022917">
        <property type="entry name" value="Phe_tRNA_ligase_alpha_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000126805" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>L-phenylalanine</name>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>L-phenylalanine</name>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00282"/>
        </source>
    </evidence>
    <sequence length="553" mass="61233" checksum="E0D33A0FCDFDE3E1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83951</accession>
    <name>O83951_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71256">
        <property type="entry name" value="B71256"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882430.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83951">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0986"/>
    <dbReference type="EnsemblBacteria" id="AAC65943">
        <property type="protein sequence ID" value="AAC65943"/>
        <property type="gene ID" value="TP_0986"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76150">
        <property type="protein sequence ID" value="AGN76150"/>
        <property type="gene ID" value="TPANIC_0986"/>
    </dbReference>
    <dbReference type="GeneID" id="57879495"/>
    <dbReference type="KEGG" id="tpa:TP_0986"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.971"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_0_1_12"/>
    <dbReference type="OMA" id="MGVCVKL"/>
    <dbReference type="OrthoDB" id="1420919at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503414" evidence="2">
        <location>
            <begin position="31"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="294" mass="32365" checksum="76843AE0E71C8C03" modified="1998-11-01" version="1">MAFTEKQKGTLCLMCSSFCFSVMSVFVRLAGDLPSIQKAFTRNLVSTLISGSMLFRARTRVHVQDLPMLSLRTVCGTLAIVANFYAVERLTLADASLLSKLSPFFTILFSCLFLGERIAPYQVVALCGAFAAGTLVVKPSHTLSHRVFPACIGAVGGMMTGAAHTCVRYLSTRGVEKFLVIFFFSFGSLLLLLPAFIWQYQPMSSPQVLTLWAAGVAVAGAQFFLTVAYRYAPKKSIPIDYTHILFSTGIGFLYFKEVPDHWTVAGIGIILAIALYVFARERERKEPTVPSHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83962</accession>
    <name>O83962_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protease IV (SppA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71255">
        <property type="entry name" value="F71255"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882441.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83962">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0997"/>
    <dbReference type="EnsemblBacteria" id="AAC26585">
        <property type="protein sequence ID" value="AAC26585"/>
        <property type="gene ID" value="TP_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0997"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.1051"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008856_1_1_12"/>
    <dbReference type="OMA" id="DPKGQYL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="133"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="3">
        <location>
            <begin position="385"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC26585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="598" mass="66735" checksum="11DE6DCF15B1D784" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83985</accession>
    <name>RADA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RadA</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Branch migration protein RadA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">radA</name>
        <name type="synonym">sms</name>
        <name type="ordered locus">TP_1022</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71251">
        <property type="entry name" value="A71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882466.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83985"/>
    <dbReference type="SMR" id="O83985"/>
    <dbReference type="STRING" id="243276.TPANIC_1022"/>
    <dbReference type="EnsemblBacteria" id="AAC65973">
        <property type="protein sequence ID" value="AAC65973"/>
        <property type="gene ID" value="TP_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1022"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_0_12"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000187943" description="DNA repair protein RadA">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="1">
        <location>
            <begin position="350"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="1">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <sequence length="455" mass="49305" checksum="435C310919A70E77" modified="1998-11-01" version="1">MAKKTERAFSCVGCGYVHPKWLGRCPECGEWNSFEETPSLSSGDVRAVKKASSSPVQAFPLCAVRAQDAQRISCGIAEFDRVLGGGAVRRSAIMIGGEPGIGKSTLLLQIAAACGKSVLYVSGEESPGQIRGRADRLNIPIQNIELLCATRVEDVERVLNTRCPTFVIVDSIQTVFSPEAGAIPMTINQLKYCANELIAWVKERDSVLFFTAHVTKDGNIAGPKVVEHMVDTVISFERNEEDIRFLRALKNRFGSVDELGIFTMGENGLSAVQDTAGFFISTRQGMFPVGSATVPVCEGSRVFMVEIQALTVPAKSSVTRVFSDRIDSARVSRVAAVIEKRVGLKFSDQDIYVNVAGGIRLYEPAVDVALAMALYSARQNTPVKTNAAFIGEVSLSGEIRPVRRLKTRLKTAYGLGFSTIYVPIGVEHDTPPPYTLRVVGTLAQTIAEIFSKAKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83993</accession>
    <name>Y1030_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1030</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1030</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71252">
        <property type="entry name" value="A71252"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83993"/>
    <dbReference type="STRING" id="243276.TPANIC_1030"/>
    <dbReference type="PRIDE" id="O83993"/>
    <dbReference type="EnsemblBacteria" id="AAC65983">
        <property type="protein sequence ID" value="AAC65983"/>
        <property type="gene ID" value="TP_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1030"/>
    <dbReference type="HOGENOM" id="CLU_1610040_0_0_12"/>
    <dbReference type="OMA" id="THFIFTT"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202375" description="Uncharacterized protein TP_1030">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="165" mass="17360" checksum="8A426E675837BBC7" modified="1998-11-01" version="1">MRGLGHEGERDFQIIGGAKPVRVLVRLHRRVLFKLNAPLQLGVTSYCGAMPSCSEKTGSAPNPGSSAPAPAQKKTARCSSLPTHFIFTTPPPPPVSSTLQKGPTGAGCVTAARPAPSSGRQGGGGALYLQFSVRRGSFVSPRAPRAAAQRTCPFSWHRIMSARNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>P29722</accession>
    <name>TA17_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>17 kDa lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tpp17</name>
        <name type="ordered locus">TP_0435</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1993" name="Infect. Immun." volume="61" first="1202" last="1210">
            <title>Lipid modification of the 17-kilodalton membrane immunogen of Treponema pallidum determines macrophage activation as well as amphiphilicity.</title>
            <authorList>
                <person name="Akins D.R."/>
                <person name="Purcell B.K."/>
                <person name="Mitra M.M."/>
                <person name="Norgard M.V."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="8454324"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="M74825">
        <property type="protein sequence ID" value="AAA27472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71323">
        <property type="entry name" value="C71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881883.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="4U3Q">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B=33-154"/>
    </dbReference>
    <dbReference type="PDBsum" id="4U3Q"/>
    <dbReference type="AlphaFoldDB" id="P29722"/>
    <dbReference type="SMR" id="P29722"/>
    <dbReference type="IntAct" id="P29722">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0435"/>
    <dbReference type="EnsemblBacteria" id="AAC65423">
        <property type="protein sequence ID" value="AAC65423"/>
        <property type="gene ID" value="TP_0435"/>
    </dbReference>
    <dbReference type="GeneID" id="57878959"/>
    <dbReference type="KEGG" id="tpa:TP_0435"/>
    <dbReference type="eggNOG" id="COG3015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685798_0_0_12"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007298">
        <property type="entry name" value="Cu-R_lipoprotein_NlpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04170">
        <property type="entry name" value="NlpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018200" description="17 kDa lipoprotein">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="89"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="103"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="129"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="4U3Q"/>
        </source>
    </evidence>
    <sequence length="156" mass="16467" checksum="03630A2AACEA13F7" modified="1993-04-01" version="1" precursor="true">MKGSVRALCAFLGVGALGSALCVSCTTVCPHAGKAKAEKVECALKGGIFRGTLPAADCPGIDTTVTFNADGTAQKVELALEKKSAPSPLTYRGTWMVREDGIVELSLVSSEQSKAPHEKELYELIDSNSVRYMGAPGAGKPSKEMAPFYVLKKTKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>P38369</accession>
    <accession>Q56358</accession>
    <name>TPN50_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Outer membrane protein Tpn50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Antigen Tpp57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tpn50</name>
        <name type="ordered locus">TP_0292</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Infect. Immun." volume="62" first="1015" last="1025">
            <title>Identification and characterization of the Treponema pallidum tpn50 gene, an ompA homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="8112835"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1995" name="Mol. Microbiol." volume="15" first="1151" last="1164">
            <title>Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture.</title>
            <authorList>
                <person name="Cox D.L."/>
                <person name="Akins D.R."/>
                <person name="Porcella S.F."/>
                <person name="Norgard M.V."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="7623668"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1995.tb02288.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Could function as a porin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell outer membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the outer membrane OOP (TC 1.B.6) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U02628">
        <property type="protein sequence ID" value="AAA20517.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="L28427">
        <property type="protein sequence ID" value="AAA99311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71344">
        <property type="entry name" value="G71344"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881741.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P38369"/>
    <dbReference type="SMR" id="P38369"/>
    <dbReference type="IntAct" id="P38369">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0292"/>
    <dbReference type="EnsemblBacteria" id="AAC65272">
        <property type="protein sequence ID" value="AAC65272"/>
        <property type="gene ID" value="TP_0292"/>
    </dbReference>
    <dbReference type="GeneID" id="57878830"/>
    <dbReference type="KEGG" id="tpa:TP_0292"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045523_1_0_12"/>
    <dbReference type="OMA" id="RGIPRFP"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0626">Porin</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000020118" description="Outer membrane protein Tpn50">
        <location>
            <begin position="27"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="300"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAA99311." evidence="3" ref="2">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAA99311." evidence="3" ref="2">
        <original>A</original>
        <variation>E</variation>
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="417" mass="47609" checksum="079F579CFDD7288C" modified="1994-10-01" version="1" precursor="true">MCMMGSVFSRKGMLCVLAVWCAASAAYPLRLRYKFRKGDTHRINSLIREDVFVNDTLAHTAEITNRITVHVSEVRVAHGSAPDAARYVCHFMTSEKSPNNTFRWGRHYESIFWRDAFGVYDIDRSFFMPVVRNVPVFPDYDIEVGDTWEHEAEEAHDLRDGFGIQTPFIVPFTVSYTYRGEVQRGSRRYHHITAAYSMSYESPKRTHGVQRNAKEGMYPVRTTGVSKQNLYWDNELGNIAEYDDEFRILLYLSGGTVLRYQGTATAKNFAPERFDPARTVVELQETLKDLHMPDAKVRETEEGVTISIENVQFDADSASLAPSEYEKLRKIAELLRAFPDRELLVSGHAARRGSVQDQQRISEERADVVARYLQELGVVDAAHVYTRGCGAQQSIAPNDSEDGRRKNRRVEITIISK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>P74934</accession>
    <name>ENO_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">TP_0817</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="7" first="261" last="265">
            <title>Nucleotide sequence of the Treponema pallidum eno gene.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Young N.R."/>
            </authorList>
            <dbReference type="PubMed" id="9255517"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="U61534">
        <property type="protein sequence ID" value="AAB39979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71278">
        <property type="entry name" value="F71278"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882261.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74934"/>
    <dbReference type="SMR" id="P74934"/>
    <dbReference type="STRING" id="243276.TPANIC_0817"/>
    <dbReference type="EnsemblBacteria" id="AAC65781">
        <property type="protein sequence ID" value="AAC65781"/>
        <property type="gene ID" value="TP_0817"/>
    </dbReference>
    <dbReference type="GeneID" id="57879335"/>
    <dbReference type="KEGG" id="tpa:TP_0817"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_12"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000133999" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="432" mass="46771" checksum="4A1D332B05376497" modified="1997-02-01" version="1">MSDIACIEAREIIDSRGNPTVEVDVSLSDGSFGRACVPSGASTGEFEALEMRDGDKERYNGKGVLKAVGTVNTLIADTLEGMDALNQGEIDHAMRNLDGTDNKSKLGANAMLGVSMACARAAADFLGVPLYRYLGGVHTFRMPVPMANIINGGKHSDNKIDFQEFMVMPIGAASMREAVRMTAEVFHALKGLLAADGKATSVGDEGGFAPDLDNEQALEYIMKAIAKAGLAPRKDVCIALDCASSELFDEGDRRGYKFWKSNPGKLFTAQEMIDLYKKWIATYPIVSIEDPLDQNDWAGYVQLTKELGDKVQIVGDDFFVTNTGRLARGIKEGSCNSILIKLNQIGTVTETVDAVRMAQNAGYAAVISHRSGETEDAFIADLAVALETGQIKTGSMSRSDRVAKYNQLMRIEEELGAQARYYGAKTFERFGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-05-25" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>P74935</accession>
    <accession>O83370</accession>
    <name>PROA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="1">GPR</shortName>
            <ecNumber evidence="1">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proA</name>
        <name type="ordered locus">TP_0350</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="8" first="63" last="70">
            <title>Nucleotide sequences of the proA and proB genes of Treponema pallidum, the syphilis agent.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
            <dbReference type="PubMed" id="9522123"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="U61535">
        <property type="protein sequence ID" value="AAB39980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71336">
        <property type="entry name" value="E71336"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881798.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342789.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74935"/>
    <dbReference type="SMR" id="P74935"/>
    <dbReference type="IntAct" id="P74935">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0350"/>
    <dbReference type="EnsemblBacteria" id="AAC65335">
        <property type="protein sequence ID" value="AAC65335"/>
        <property type="gene ID" value="TP_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0350"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_12"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000189806" description="Gamma-glutamyl phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB39980." evidence="2" ref="1">
        <original>P</original>
        <variation>A</variation>
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="428" mass="46608" checksum="B4E2BC5BE46D5C45" modified="1998-12-15" version="3">MVEVYARLRAAVARLAVCSAAEKDGALRAVRDALHAQREDILRANAQDLARAREAGLAAPLVARLALSEHLLEDMLRSLTVLSLQRDPIGEIIEGYTLANGLEIRKVRVPLGVVAVIYESRPNVTVDAFALAYKSGNAVLLRAGSAASYSNAPLLRAIHVGLKKAHGVVDAVAVPPVLEEKYGDVDHILRARGFIDAVFPRGGAALIRRVVEGAHVPVIETGCGVCHLYVDESANIDVALQIAENAKLQKPAACNSVETLLVHRAVARPFLHRVQEIFATCEETTRKPGGVDFFCDAESFSLLTERGARKNVFHAQAETWDREYLDYQVSVRVVPNLEEALRHIARHSTKHSEVIVTRDRARARRFHQEVDAACVYVNASSRFTDGGQFGMGAEIGVSTQKLHARGPMGLCALTTSKYLIDGEGQVRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P96115</accession>
    <accession>O83197</accession>
    <name>RUVB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">TP_0162</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-82</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71359">
        <property type="entry name" value="H71359"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881609.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96115"/>
    <dbReference type="SMR" id="P96115"/>
    <dbReference type="IntAct" id="P96115">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0162"/>
    <dbReference type="EnsemblBacteria" id="AAC65150">
        <property type="protein sequence ID" value="AAC65150"/>
        <property type="gene ID" value="TP_0162"/>
    </dbReference>
    <dbReference type="GeneID" id="57878704"/>
    <dbReference type="KEGG" id="tpa:TP_0162"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_12"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="OrthoDB" id="874197at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000165623" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AAC45724." evidence="3" ref="2">
        <original>L</original>
        <variation>V</variation>
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="350" mass="38665" checksum="69A2E3B3EB95CA1A" modified="1998-12-15" version="2">MDHTASLSPVRPEAQPTDDRERALRPRLLKDFLGQEKTKRNLRLFIQAARDRNESLDHLFLIGPPGLGKTTLAHITACELGVECKVTGAPALDKPKDLAGILTALSERSVFFVDEIHRLKPAIEEMLYIAMEDYELDWVIGQGPSARTVRIPLPPFTLIGATTRAGMVSSPLISRFGIVERFEFYTPEELAAIVQRSARLLDITLDARAALALARCSRGTPRVANRLLRRIRDFAQVAGSAHISETIVRAGLAHLKIDELGLELHDIQLLRVMIEHFGGGPVGAETLAISLGESPETLEDYYEPYLIQIGLMQRTPRGRMATARAYAHLGLPVPEARTLTPHSPEQGTLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>P96128</accession>
    <name>DER_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">TP_0689</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1996-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="U70661">
        <property type="protein sequence ID" value="AAB38705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71292">
        <property type="entry name" value="F71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882134.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96128"/>
    <dbReference type="SMR" id="P96128"/>
    <dbReference type="STRING" id="243276.TPANIC_0689"/>
    <dbReference type="EnsemblBacteria" id="AAC65658">
        <property type="protein sequence ID" value="AAC65658"/>
        <property type="gene ID" value="TP_0689"/>
    </dbReference>
    <dbReference type="GeneID" id="57879214"/>
    <dbReference type="KEGG" id="tpa:TP_0689"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_1_12"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000179066" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="198"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="374"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <sequence length="460" mass="52121" checksum="A2E191853D520A78" modified="1997-05-01" version="1">MKGQDVILCDGGRHFSYKVLPRVVIVGRPNVGKSTLFNRLLGRRRSITSNTSGVTRDSIEETVILRGFPLRLVDTSGFTVFSEKKASRQHIDTLVLEQTYKSIQCADKILLVLDGTCESAEDEEVIQYLRPYWGKLIAAVNKTEGGEEVHYNYARYGFSTLICVSAEHGRNIDALERAIIQNLFSVDERRELPKDDVVRLAIVGKPNTGKSTLMNYLMRRTVSLVCDRAGTTRDVVTGHVEFKQYKFIIADTAGIRKRQKVYESIEYYSVIRAISILNAVDIVLYIVDARDGFSEQDKKIVSQISKRNLGVIFLLNKWDLLEGSTSLIAKKKRDVRTAFGKMNFVPVVPVSAKTGHGISDALHCVCKIFAQLNTKVETSALNTALKDWVTSYPPPRKYGHVSLKYLVQVSVRPIEFLLFANRPDRIPENYVRFLQNRIREDLGLDSIPVKLTIRKNCRKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O66107</accession>
    <name>RPE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpe</name>
        <name type="ordered locus">TP_0945</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Radolf J.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="U97573">
        <property type="protein sequence ID" value="AAC08057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71260">
        <property type="entry name" value="G71260"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882388.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O66107"/>
    <dbReference type="SMR" id="O66107"/>
    <dbReference type="IntAct" id="O66107">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0945"/>
    <dbReference type="EnsemblBacteria" id="AAC65902">
        <property type="protein sequence ID" value="AAC65902"/>
        <property type="gene ID" value="TP_0945"/>
    </dbReference>
    <dbReference type="GeneID" id="57879455"/>
    <dbReference type="KEGG" id="tpa:TP_0945"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_12"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000171583" description="Ribulose-phosphate 3-epimerase">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <sequence length="218" mass="23514" checksum="0066263301FA2FCA" modified="1998-08-01" version="1">MERSFTLAPSLLSADFSALDRALVYLEAHGAQWVHLDVMDGHFVPNLTFGAPVLRCLRSKTHLPFDVHLMVSRPADLIEDFVQAGADFLTFHIEAEVHAHRLIHAIRGRGVKVGISLVPSTPVAALSEVLPFVDLVLVMTVNPGFSGQQMIAHCLSKVSALVQMRTERGYSYMISVDGGIDCRTLPQALDAGADVIVSGSAFFSGTLRSLLCKDSSGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83056</accession>
    <name>Y012_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0012</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0012</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71377">
        <property type="entry name" value="A71377"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83056"/>
    <dbReference type="IntAct" id="O83056">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65012">
        <property type="protein sequence ID" value="AAC65012"/>
        <property type="gene ID" value="TP_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0012"/>
    <dbReference type="HOGENOM" id="CLU_2977937_0_0_12"/>
    <dbReference type="OMA" id="PVGGWTI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202174" description="Uncharacterized protein TP_0012">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <sequence length="58" mass="6894" checksum="CB233BBA76F0A782" modified="1998-11-01" version="1">MVREPSIRGREGIPFWFAHDDFLMLYHKYTIDFPVGGGWTIRLSVLERWCVQIVKGRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83065</accession>
    <name>Y021_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0021</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0021</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71376">
        <property type="entry name" value="A71376"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881470.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83065"/>
    <dbReference type="IntAct" id="O83065">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0021"/>
    <dbReference type="EnsemblBacteria" id="AAC65021">
        <property type="protein sequence ID" value="AAC65021"/>
        <property type="gene ID" value="TP_0021"/>
    </dbReference>
    <dbReference type="GeneID" id="57878563"/>
    <dbReference type="KEGG" id="tpa:TP_0021"/>
    <dbReference type="HOGENOM" id="CLU_168354_0_0_12"/>
    <dbReference type="OrthoDB" id="666201at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202177" description="Uncharacterized protein TP_0021">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <sequence length="88" mass="10275" checksum="B70CF04E560BC31F" modified="1998-11-01" version="1">MDDARYAEWSASLVQLPDTHFFDLMRLYLGVLKTPFHKQRLVQQLSAFLQRKSIQNAVVQMLDELDLLFISVVMCVPRATLELLTIFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83084</accession>
    <name>MNMG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">TP_0044</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71374">
        <property type="entry name" value="C71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881493.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83084"/>
    <dbReference type="SMR" id="O83084"/>
    <dbReference type="IntAct" id="O83084">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0044"/>
    <dbReference type="EnsemblBacteria" id="AAC65038">
        <property type="protein sequence ID" value="AAC65038"/>
        <property type="gene ID" value="TP_0044"/>
    </dbReference>
    <dbReference type="GeneID" id="57878585"/>
    <dbReference type="KEGG" id="tpa:TP_0044"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_12"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117206" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="630" mass="70176" checksum="1B52C6F02C1EC275" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O83089</accession>
    <name>O83089_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1198251">
            <id>O83089</id>
        </interactant>
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
            <label>dnaB</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71372">
        <property type="entry name" value="D71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881499.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83089">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0050"/>
    <dbReference type="EnsemblBacteria" id="AAC65046">
        <property type="protein sequence ID" value="AAC65046"/>
        <property type="gene ID" value="TP_0050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75270">
        <property type="protein sequence ID" value="AGN75270"/>
        <property type="gene ID" value="TPANIC_0050"/>
    </dbReference>
    <dbReference type="GeneID" id="57878591"/>
    <dbReference type="KEGG" id="tpa:TP_0050"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.46"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_1_2_12"/>
    <dbReference type="OMA" id="QEYFDFK"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="202" mass="23208" checksum="F703AF702ABC919A" modified="1998-11-01" version="1">MKKRFIPYNVIRDEGFGMARRIVADRFVPTVMYVPIRGGVYLGNVLNEYLTIAYKAEPPILYAAVVAHSHCDLRKRRVISVDGWTYPPEYLRVGDKVLIVDDIFDSGATINYIASLLMQKGLARGDIRVAVFNYKVFVGEKQPPVLPDYWCIKHEVRSEADNEWFHYMSHELSGLTAAELEQYYYAQNPALRKTLADINNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83095</accession>
    <name>O83095_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxaloacetate decarboxylase, subunit alpha (OadA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71373">
        <property type="entry name" value="B71373"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881505.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0056"/>
    <dbReference type="EnsemblBacteria" id="AAC65051">
        <property type="protein sequence ID" value="AAC65051"/>
        <property type="gene ID" value="TP_0056"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75276">
        <property type="protein sequence ID" value="AGN75276"/>
        <property type="gene ID" value="TPANIC_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0056"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.53"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_4_3_12"/>
    <dbReference type="OMA" id="GYHALEM"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005776">
        <property type="entry name" value="OadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01108">
        <property type="entry name" value="oadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="519"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="593" mass="64099" checksum="21E06AD7ACAC4CF3" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83105</accession>
    <name>Y066_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0066</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0066</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71371">
        <property type="entry name" value="B71371"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881515.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83105"/>
    <dbReference type="SMR" id="O83105"/>
    <dbReference type="IntAct" id="O83105">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0066"/>
    <dbReference type="EnsemblBacteria" id="AAC65065">
        <property type="protein sequence ID" value="AAC65065"/>
        <property type="gene ID" value="TP_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0066"/>
    <dbReference type="eggNOG" id="ENOG502ZPBI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2157247_0_0_12"/>
    <dbReference type="OMA" id="WLHEEGN"/>
    <dbReference type="OrthoDB" id="1942075at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202184" description="Uncharacterized protein TP_0066">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <sequence length="104" mass="12013" checksum="37422ECBF0D8D894" modified="1998-11-01" version="1">MQRVLESDTPYFVKGIQRPVSTLSDRDRALLNRRGNAYLNEGKLQEAARVFITTGYHDGLTRIGDVYMRKADVLTALRFYYFARNEQKMRPIVSALSVLIRCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83120</accession>
    <name>O83120_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71369">
        <property type="entry name" value="H71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881530.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83120">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0081"/>
    <dbReference type="EnsemblBacteria" id="AAC65076">
        <property type="protein sequence ID" value="AAC65076"/>
        <property type="gene ID" value="TP_0081"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75300">
        <property type="protein sequence ID" value="AGN75300"/>
        <property type="gene ID" value="TPANIC_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0081"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.81"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_4_1_12"/>
    <dbReference type="OMA" id="NIANGFY"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="282" mass="31612" checksum="D70D419BA25D5043" modified="1998-11-01" version="1">MHLYKNSESSVIYYVKSLGQLCAVLRNVAQVQPVGGGTGLVQYQITPVLTLPSHLVVLNGVPELKDISKTEHFLEFGGAVSLQAIVRLGRKNIPVALHEALSHAANPGIRTLATIGGNIAGTRPHASALAPLIALDAKMEVRTGHENFWISVAHYAHARSDTLRHRSHVITRIRLPTDYWDFSYYRRIGSRALFGERADFVFLAQQQKNALSEMRMVFFSDVVMRNREFDNLLLGRAIPLSAGDIAAIVYRSREFFAPESFKSAYIAHCFFHLLEDCLRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83124</accession>
    <name>O83124_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="G71367"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0086"/>
    <dbReference type="EnsemblBacteria" id="AAC65081">
        <property type="protein sequence ID" value="AAC65081"/>
        <property type="gene ID" value="TP_0086"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75305">
        <property type="protein sequence ID" value="AGN75305"/>
        <property type="gene ID" value="TPANIC_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0086"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.86"/>
    <dbReference type="eggNOG" id="ENOG502ZPJT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="907046at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="158"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="314" mass="34814" checksum="DE37159E7D265E50" modified="1998-11-01" version="1">MTFCLLGLYHARVEFATREQLNRYYDLYKDVDVTFSKDVMQALCFNARQVCVRSAGGQCSCVMNSVSMVGAKVILSRKSSLLESIQVEGASVSIRFSFFESDARDAVSFFVTARVLGVEDYAQSTELVVLSVAYTQRIPDMLIERLGLLVEANISSKKRKSERIAVNKESMRRIGLMRAETIVFIQAIPRRCVLRDVSFGGAKFIMMGVAPFLKGKETVLKLDFEEPSTSMSIRGHVVRADQVEGRKDLVAVAMEYDFDVVPVAYRMCLNRYASDRCRRFPGTDEDCSAASAGDPGRSSAGAEGIDLSVPFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83138</accession>
    <name>O83138_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="H71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881549.1">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0100"/>
    <dbReference type="EnsemblBacteria" id="AAC65095">
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        <property type="gene ID" value="TP_0100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75319">
        <property type="protein sequence ID" value="AGN75319"/>
        <property type="gene ID" value="TPANIC_0100"/>
    </dbReference>
    <dbReference type="GeneID" id="57878640"/>
    <dbReference type="KEGG" id="tpa:TP_0100"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.100"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_4_12"/>
    <dbReference type="OMA" id="MIGKPFP"/>
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    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_1"/>
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    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503403" evidence="4">
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            <begin position="34"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="59"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="200" mass="22010" checksum="4AA0DA2E3C58E2E4" modified="1998-11-01" version="1">MSCSRTTGALRAVPLVFRSVLVLAVWGVSCVQAADVAHNADVPSRSLKALERFRFFVYPKPLDLSSDFHAKALKGEALVPSLFKGKVTLLNFWATWCPPCRAEMPSMDRMQALMRGNDFQIVAVNVGDSRKQVESFIARGKHTFPIYLDEEGSLGSVFASRGLPTTYVVDKAGRIVAVVVGSVEYDQPELVALFKELARD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="151" xmlns="http://uniprot.org/uniprot">
    <accession>O83141</accession>
    <name>O83141_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent DNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="6 7">
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="C71367"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0103"/>
    <dbReference type="EnsemblBacteria" id="AAC65098">
        <property type="protein sequence ID" value="AAC65098"/>
        <property type="gene ID" value="TP_0103"/>
    </dbReference>
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        <property type="protein sequence ID" value="AGN75322"/>
        <property type="gene ID" value="TPANIC_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0103"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.103"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_12"/>
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    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="365"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="607" mass="67286" checksum="105452104964803A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83145</accession>
    <name>O83145_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LicC protein (LicC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0107</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71365">
        <property type="entry name" value="H71365"/>
    </dbReference>
    <dbReference type="IntAct" id="O83145">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0107"/>
    <dbReference type="EnsemblBacteria" id="AAC26555">
        <property type="protein sequence ID" value="AAC26555"/>
        <property type="gene ID" value="TP_0107"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75326">
        <property type="protein sequence ID" value="AGN75326"/>
        <property type="gene ID" value="TPANIC_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0107"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.108"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467630_0_0_12"/>
    <dbReference type="OMA" id="YKWTGTM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017190">
        <property type="entry name" value="Bifunc_CCT/choline_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037383">
        <property type="entry name" value="LicCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="246"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC26555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="525" mass="61044" checksum="E46DDCACC79BAB10" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83159</accession>
    <name>PCKG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="1">PEP carboxykinase</shortName>
            <shortName evidence="1">PEPCK</shortName>
            <ecNumber evidence="1">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="1">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pckG</name>
        <name type="synonym">pckA</name>
        <name type="ordered locus">TP_0122</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71364">
        <property type="entry name" value="A71364"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881571.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83159"/>
    <dbReference type="SMR" id="O83159"/>
    <dbReference type="STRING" id="243276.TPANIC_0122"/>
    <dbReference type="EnsemblBacteria" id="AAC65112">
        <property type="protein sequence ID" value="AAC65112"/>
        <property type="gene ID" value="TP_0122"/>
    </dbReference>
    <dbReference type="GeneID" id="57878665"/>
    <dbReference type="KEGG" id="tpa:TP_0122"/>
    <dbReference type="eggNOG" id="COG1274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_12"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="OrthoDB" id="267285at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000103616" description="Phosphoenolpyruvate carboxykinase [GTP]">
        <location>
            <begin position="1"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="514"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <sequence length="618" mass="68125" checksum="4230B8F77DDD4AA6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83170</accession>
    <name>Y134_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0134</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0134</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TP013X lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71363">
        <property type="entry name" value="C71363"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881582.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83170"/>
    <dbReference type="IntAct" id="O83170">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0134"/>
    <dbReference type="EnsemblBacteria" id="AAC65125">
        <property type="protein sequence ID" value="AAC65125"/>
        <property type="gene ID" value="TP_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0134"/>
    <dbReference type="eggNOG" id="ENOG5030DBM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056007_0_0_12"/>
    <dbReference type="OMA" id="TGWGTNC"/>
    <dbReference type="OrthoDB" id="1890188at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018066" description="Uncharacterized lipoprotein TP_0134">
        <location>
            <begin position="29"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="376" mass="40101" checksum="45155887C68283ED" modified="1998-11-01" version="1" precursor="true">MCKPRVWRIAHTIVHVGALLLGTSQLTTCDFSGIFATIQQEVAIKSPSIPGAIYGLVKAGDKLYATNGRLWEKELNGIKWKPVPFLDGQDKRIDSLAASNTCVFACVSGDGVYKYTAGTTSSQKESNTDKAQAVVQMSDGKVVLQCALGDEKTTPSDADERLLGGGQGYLVTSKGFYTLPGSASCEVISETKDVTCKAEAPILASACDGSNTYILTKDKVYCRYTNGSGSTPTTWCDVEHKVSEPLALAVFKNKGETFLLVGGQQGYGEIKIATASGSSSSSSCVPLTAENVHATTGWGANCSTPEGSAEQYRSTIGRWAVSGIYVIKKDTSGGRKKRSTSTDCERPDLYVAVGDASDTYTGLWKFDTATNTWNRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83171</accession>
    <name>Y135_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0135</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0135</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71363">
        <property type="entry name" value="D71363"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83171"/>
    <dbReference type="IntAct" id="O83171">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65126">
        <property type="protein sequence ID" value="AAC65126"/>
        <property type="gene ID" value="TP_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0135"/>
    <dbReference type="HOGENOM" id="CLU_983323_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202197" description="Uncharacterized protein TP_0135">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <sequence length="313" mass="33849" checksum="C43480D60157EC2D" modified="1998-11-01" version="1">MRASEVIADIYPGGDKLRSARVSLLSLFFNHFFARPGYAAICSTGTQGPALCQLKVTAGPCFEQKTVVRRRVVVLVAEAGPHRQRQTDAPEGERVTCIQRYRNGKVGTQPLLLVIERITAGVLRARINPERQAAIHKILVSKRHPKRGVNFLIPVGCNAPRSPRAVLHQSTWKRGTAPINETRAIPRPAAVTSHDAAGATSCAYAAPAATPTPQRRPAESVSRVPRTVLAVSYVFSLHTFQKAAGNPHSLPKFYPPPANICRVLFLQEGRAPRTTAAYPVRACNILTGEVFSHTGEVLCANRACGASPTPSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83180</accession>
    <name>O83180_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine ABC transporter, thiamine-binding periplasmic protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71361">
        <property type="entry name" value="B71361"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881592.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0144"/>
    <dbReference type="EnsemblBacteria" id="AAC65133">
        <property type="protein sequence ID" value="AAC65133"/>
        <property type="gene ID" value="TP_0144"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75364">
        <property type="protein sequence ID" value="AGN75364"/>
        <property type="gene ID" value="TPANIC_0144"/>
    </dbReference>
    <dbReference type="GeneID" id="57878686"/>
    <dbReference type="KEGG" id="tpa:TP_0144"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.150"/>
    <dbReference type="eggNOG" id="COG4143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_6_1_12"/>
    <dbReference type="OMA" id="PTTNWMY"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="335" mass="36813" checksum="25D61EF463C44370" modified="1998-11-01" version="1">MAHRMRVVFCCAAALSLCCCSRSRTDAPSLVIYVYDSFASEWGPGPELARRFYAKTGYSVQYVVFEDVTRAIHRAIRDQHTPSSRGADLIIGVDQYTLPLAREADLFSPYQPALPLPHALRIDPHNLAVPYDWGYVAFMFNTDAALPEPQRLSDLANPVYAKSIALADPHTNVLGTIFIGWAHTSLGAAWPAFWNTLYRANLLALAPSWSAAYGLFTAGEAALVLSYTTSAAYHLHHDNHTRFKPLLFPEGHPMHIEGISLVKRTKHARVATQFIDFLLSTEAQELLPLTQWMYPANPDVPLPAAFSAVPQPAACVSLSPQMCRAAAAALHASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83187</accession>
    <name>O83187_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen fixation protein (RnfC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71362">
        <property type="entry name" value="A71362"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0152"/>
    <dbReference type="EnsemblBacteria" id="AAC65136">
        <property type="protein sequence ID" value="AAC65136"/>
        <property type="gene ID" value="TP_0152"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75371">
        <property type="protein sequence ID" value="AGN75371"/>
        <property type="gene ID" value="TPANIC_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0152"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.159"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010808_6_0_12"/>
    <dbReference type="OMA" id="YPMGSEK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="514" mass="55617" checksum="2B02C8698B9C1B41" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83206</accession>
    <name>Y176_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0176</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0176</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71358">
        <property type="entry name" value="E71358"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881623.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83206"/>
    <dbReference type="IntAct" id="O83206">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65166">
        <property type="protein sequence ID" value="AAC65166"/>
        <property type="gene ID" value="TP_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0176"/>
    <dbReference type="HOGENOM" id="CLU_2468121_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202207" description="Uncharacterized protein TP_0176">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <sequence length="88" mass="10104" checksum="49CC07DA9855A580" modified="1998-11-01" version="1">MTNVFKKNIRALRMRYQDIALTLERTHSNGIYAGTLTAHTGENIPFFRNNRTLHSRYNPWIEAERTLPAQHASFFFVASGQVSTSVFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83224</accession>
    <name>RL22_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">TP_0194</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71355">
        <property type="entry name" value="D71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881641.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83224"/>
    <dbReference type="SMR" id="O83224"/>
    <dbReference type="IntAct" id="O83224">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0194"/>
    <dbReference type="EnsemblBacteria" id="AAC65179">
        <property type="protein sequence ID" value="AAC65179"/>
        <property type="gene ID" value="TP_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0194"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_1_12"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125254" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="124" mass="14097" checksum="FAABD47CF7BF8411" modified="1998-11-01" version="1">MTERVTYRAKTKFLVASPTKVRPVANVVKCKPYVRAMALLGHLPHKGARLISKVMKSAASNAIDRDKRLDEERLFVRDIQIDEGPRLKRLWCRGRGRGDVQLKRMCHITVVVEESVRTKDGSKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83231</accession>
    <name>RL5_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">TP_0201</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71356">
        <property type="entry name" value="C71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881648.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0201"/>
    <dbReference type="EnsemblBacteria" id="AAC65186">
        <property type="protein sequence ID" value="AAC65186"/>
        <property type="gene ID" value="TP_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0201"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_12"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125018" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="185" mass="20804" checksum="FF5D4FFBBD7BF2E0" modified="1998-11-01" version="1">MTDHSCIPELKVRYVQQIVPDMMRDFGYSTVMQVPKLLKIVLSMGLGEALANRKLLDASVADLGVISGQHAVKTRARKSIANFKLREGNEIGVMVTLRRSRMYEFLHRLINVALPRVKDFRGVSPXGFDGHGNYSMGITEQIIFPEIDFDKIERISGLNVNVVTSAQTDQEARTLLTKLGMPFRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83242</accession>
    <name>RPOA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">TP_0212</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71352">
        <property type="entry name" value="B71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881660.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83242"/>
    <dbReference type="SMR" id="O83242"/>
    <dbReference type="IntAct" id="O83242">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0212"/>
    <dbReference type="EnsemblBacteria" id="AAC65201">
        <property type="protein sequence ID" value="AAC65201"/>
        <property type="gene ID" value="TP_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0212"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_12"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175412" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="261"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="351" mass="39545" checksum="81F01E337CBAB5D8" modified="1998-11-01" version="1">MPRRNLLKGFKRPKVLEFLSENSSECYGKFTASPFETGFGTTVGNCLRRVLLSSIQGYAVTGVRITSFDADGVAHFISSEFEQIPHVREDTLEILNNFKRLRFLLPQGAESSTFTYEFRGAVSLTGKDFAKKFQLEVLSQDLLIMEMMDGAHVEVELHVEFGRGYVPAESHDRYADLVGVIPVDAIFSPVLRVRYDIQSCRVGQRGDYDQLSLEVWTDGTVRPEDAIAEAAKIIKEHFTVFVNFDETALDLEDEPEEDDPAVLELLNTKIADVDFSVRARNCLLTMGIKTLGELTRISEQTLANTRNVGKKSLSEIQGKLQEYNLRLGMADYNHVGVVSRLMRQKEEIDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83250</accession>
    <name>O83250_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D,D-carboxypeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71353">
        <property type="entry name" value="B71353"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881669.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0221"/>
    <dbReference type="EnsemblBacteria" id="AAC65208">
        <property type="protein sequence ID" value="AAC65208"/>
        <property type="gene ID" value="TP_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0221"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.240"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054193_4_0_12"/>
    <dbReference type="OMA" id="WHYLYIG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="1">
        <location>
            <begin position="108"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29193" checksum="DB5601245133BE56" modified="1998-11-01" version="1">MARWNCVCVCRVRVSCSGKCGLAAGRGSGGSASCACCCEARGASCAPCTRLCAQGREFLQELDAVLTTEGYLLRLVDKKHPLPETFVPKHLVPVREQWLFFSKGRSLLLTKIAYEALHQLIQAAARDGVALSVGSAYRSFAYQKKLFSWYAQEHGMQEAMRFSAREGTSQHQLGTVVDFGSITPAFARSDAGRWTQRNAHRFGWSLSFPPGYEQVTGYVWEPWHFRYVGVRACALQKKWFEDIQQYMLGFIHEWKVNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83259</accession>
    <name>O83259_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PseudoU_synth_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71349">
        <property type="entry name" value="A71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881679.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0231"/>
    <dbReference type="EnsemblBacteria" id="AAC65220">
        <property type="protein sequence ID" value="AAC65220"/>
        <property type="gene ID" value="TP_0231"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75444">
        <property type="protein sequence ID" value="AGN75444"/>
        <property type="gene ID" value="TPANIC_0231"/>
    </dbReference>
    <dbReference type="GeneID" id="57878772"/>
    <dbReference type="KEGG" id="tpa:TP_0231"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.235"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_4_12"/>
    <dbReference type="OMA" id="FGTSGIM"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="216" mass="23859" checksum="7A59074953340CCB" modified="1998-11-01" version="1">MALPIIFQDAAVVAVDKPAGLAVQPGARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLLFAKHARAAALYQGILGSMRVIKRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRAAHTAYRVLRATDTHTYLELTLHSGRTHQIRIHLAALGCPIIGDDKYGDFARNKACARAWGVKRLQLFAHSLVLPCACKPLVLRARMPVHFLRALDAVAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83266</accession>
    <name>RL1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">TP_0238</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71349">
        <property type="entry name" value="H71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881686.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83266"/>
    <dbReference type="SMR" id="O83266"/>
    <dbReference type="STRING" id="243276.TPANIC_0238"/>
    <dbReference type="PRIDE" id="O83266"/>
    <dbReference type="EnsemblBacteria" id="AAC65226">
        <property type="protein sequence ID" value="AAC65226"/>
        <property type="gene ID" value="TP_0238"/>
    </dbReference>
    <dbReference type="GeneID" id="57878780"/>
    <dbReference type="KEGG" id="tpa:TP_0238"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_12"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125768" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="226" mass="24977" checksum="C2BBB130D47002D1" modified="1998-11-01" version="1">MKRGKKYRAAVARYDRAERFSLDRAVGLLKEVRYASFDETVEVHVSLRLKKNQTVRDTVVLPHRFRAEVRVLVFCKEDRVSEALAAGAAYAGGAEYLEKVKGGWFDFDVVVASPDMMKDVGRLGMVLGRRGLMPNPRTGTVSADLGAAVCELKKGRVEFRADKTGVVHLAVGKTTMDSAQIVENVDVFLSEMDRKKPVDVKAGFVRSISLSSSMGPGIWVVHKSEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83269</accession>
    <name>RPOB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">TP_0241</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71350">
        <property type="entry name" value="C71350"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881689.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83269"/>
    <dbReference type="SMR" id="O83269"/>
    <dbReference type="STRING" id="243276.TPANIC_0241"/>
    <dbReference type="EnsemblBacteria" id="AAC65229">
        <property type="protein sequence ID" value="AAC65229"/>
        <property type="gene ID" value="TP_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0241"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_1_12"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000047987" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <sequence length="1178" mass="132447" checksum="E429EF184B5DB997" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83277</accession>
    <name>Y250_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0250</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0250</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71348">
        <property type="entry name" value="E71348"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83277"/>
    <dbReference type="STRING" id="243276.TPANIC_0250a"/>
    <dbReference type="EnsemblBacteria" id="AAC65242">
        <property type="protein sequence ID" value="AAC65242"/>
        <property type="gene ID" value="TP_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0250"/>
    <dbReference type="HOGENOM" id="CLU_2670012_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202219" description="Uncharacterized protein TP_0250">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="75" mass="8158" checksum="22D2F8511967FC8D" modified="1998-11-01" version="1">MSFPSLLFLGFSGVLAFGEVGWVGVYPPGRGMIRVRCVGCVVGWLGLRRVLVRGGIWLLLHPGIGRVLCLYLGAW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83278</accession>
    <name>DBH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA-binding protein HU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hup</name>
        <name type="ordered locus">TP_0251</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71348">
        <property type="entry name" value="F71348"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881700.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83278"/>
    <dbReference type="SMR" id="O83278"/>
    <dbReference type="IntAct" id="O83278">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0251"/>
    <dbReference type="EnsemblBacteria" id="AAC65236">
        <property type="protein sequence ID" value="AAC65236"/>
        <property type="gene ID" value="TP_0251"/>
    </dbReference>
    <dbReference type="GeneID" id="57878792"/>
    <dbReference type="KEGG" id="tpa:TP_0251"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_1_1_12"/>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0226">DNA condensation</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000104991" description="DNA-binding protein HU">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="105" mass="11649" checksum="740A699C133CA5F0" modified="1998-11-01" version="1">MKRVRRTRSFVVDALCDEVDLSRRHVARVVDSFVSVVTAALERGETVELRDFGVFESRVRKASVGKSIKTGEVVSIPSHCVVVFRPSKRLKSAVRGYRSGEVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O83303</accession>
    <name>O83303_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytidylate kinase</fullName>
            <shortName evidence="10">CK</shortName>
            <ecNumber evidence="10">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytidine monophosphate kinase</fullName>
            <shortName evidence="10">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cmk</name>
        <name evidence="13" type="ordered locus">TP_0279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="10"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71343">
        <property type="entry name" value="B71343"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881728.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83303"/>
    <dbReference type="STRING" id="243276.TPANIC_0279"/>
    <dbReference type="EnsemblBacteria" id="AAC65266">
        <property type="protein sequence ID" value="AAC65266"/>
        <property type="gene ID" value="TP_0279"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75489">
        <property type="protein sequence ID" value="AGN75489"/>
        <property type="gene ID" value="TPANIC_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0279"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.283"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_1_0_12"/>
    <dbReference type="OMA" id="SLNEFRY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="322"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="399"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="494"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="579"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="666"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="753"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="41"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAC65266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="863" mass="95563" checksum="1BBA56BBA07A6319" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83312</accession>
    <name>O83312_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat polysaccharide biosynthesis protein (SpsF)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71344">
        <property type="entry name" value="C71344"/>
    </dbReference>
    <dbReference type="IntAct" id="O83312">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65270">
        <property type="protein sequence ID" value="AAC65270"/>
        <property type="gene ID" value="TP_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0288"/>
    <dbReference type="HOGENOM" id="CLU_882609_0_0_12"/>
    <dbReference type="OMA" id="FIIQARM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="315" mass="35283" checksum="2ABAB16D80750008" modified="1998-11-01" version="1">MEQDRSGVAVIVQARVDSTRLPGKALLPLMGEPLIHYVLQATRVIPAETYILACDEHSKKDFEPVARAHGFYCISGSAEDVLHRFCIAVKAFEHSFPIRTVVRVTGDNPFLFHEAAAAALLRYAELDEPDYFTFTGLPYGSGVEILKARSLLLADRLPLEAYDREHVGPALHRRPGIFVCVREPAAAAWYHPDVRVTVDTQEDFQRAQHMMEYVCTLQCPFPLSSDVILDAYAYARQVVVFVPSVKIGQGAGHLYRAAYLVLRLQGRVRCCLYVPDRSLLCKLSTPFPEELIVDTVPADASLIVVDNFRTCYVRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83321</accession>
    <accession>O83322</accession>
    <name>RFUB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable riboflavin import ATP-binding protein RfuB</fullName>
            <ecNumber evidence="3">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfuB</name>
        <name type="ordered locus">TP_0299/TP_0300</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00615" last="E00615">
            <title>Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Biddy B.A."/>
                <person name="Liu W.Z."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="23404400"/>
            <dbReference type="DOI" id="10.1128/mBio.00615-12"/>
        </citation>
        <scope>IDENTIFICATION OF FRAMESHIFT</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAC65288" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="4">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAC65293" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65293.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65288.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71341">
        <property type="entry name" value="E71341"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342787.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83321"/>
    <dbReference type="STRING" id="243276.TPANIC_0300"/>
    <dbReference type="EnsemblBacteria" id="AAC65288">
        <property type="protein sequence ID" value="AAC65288"/>
        <property type="gene ID" value="TP_0300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65293">
        <property type="protein sequence ID" value="AAC65293"/>
        <property type="gene ID" value="TP_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0299"/>
    <dbReference type="KEGG" id="tpa:TP_0300"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.318"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686724_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000202229" description="Probable riboflavin import ATP-binding protein RfuB">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="343"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23404400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="23404400"/>
        </source>
    </evidence>
    <sequence length="586" mass="64410" checksum="86C8FFE4D416A329" modified="2018-03-28" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83347</accession>
    <name>O83347_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cationic outer membrane protein (OmpH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71339">
        <property type="entry name" value="B71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881775.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83347"/>
    <dbReference type="STRING" id="243276.TPANIC_0327"/>
    <dbReference type="EnsemblBacteria" id="AAC65314">
        <property type="protein sequence ID" value="AAC65314"/>
        <property type="gene ID" value="TP_0327"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75526">
        <property type="protein sequence ID" value="AGN75526"/>
        <property type="gene ID" value="TPANIC_0327"/>
    </dbReference>
    <dbReference type="GeneID" id="57878858"/>
    <dbReference type="KEGG" id="tpa:TP_0327"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.325"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124474_0_0_12"/>
    <dbReference type="OMA" id="DNPYILY"/>
    <dbReference type="OrthoDB" id="1752797at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19716" checksum="2E9F63EB1AE2474F" modified="1998-11-01" version="1">MKATLTFVFMLLTSLLQGQSQHITRFAVIDAARIYSTFWRDSRVLRDYESKKARHQGEIQKMSDELVELRQKKVDAQMQQNIASVQKYEVLIASKTALLLEYSKTSNDELTALRKTLIADDAFYAKLYAAIRRIAESEGYSIVLDLQKNAGILWYSHSVDITEDVLRELSSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83358</accession>
    <name>Y338_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0338</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0338</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71337">
        <property type="entry name" value="H71337"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881786.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83358"/>
    <dbReference type="SMR" id="O83358"/>
    <dbReference type="IntAct" id="O83358">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0338"/>
    <dbReference type="EnsemblBacteria" id="AAC65329">
        <property type="protein sequence ID" value="AAC65329"/>
        <property type="gene ID" value="TP_0338"/>
    </dbReference>
    <dbReference type="GeneID" id="57878868"/>
    <dbReference type="KEGG" id="tpa:TP_0338"/>
    <dbReference type="HOGENOM" id="CLU_104656_0_0_12"/>
    <dbReference type="OMA" id="PEPYTEN"/>
    <dbReference type="OrthoDB" id="2040023at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014245" description="Uncharacterized protein TP_0338">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="162" mass="18367" checksum="718126C5CCC91F32" modified="1998-11-01" version="1" precursor="true">MARVYILFFSVFFVFPLFSEDAARDVEPSDAPVPYEDTEFSLWQKELYRFEALSIGAFPIVTLLSFITYDIIRLIQQWSTKPPTWWALIIPGAELPPLSTKERAIVFGVAVGISVTIGLIDVTYRAVKRAIHRRSLERSQLVPDPIELVPLDSFVEGTDDST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O83361</accession>
    <name>MURC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">TP_0341</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71338">
        <property type="entry name" value="C71338"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881789.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83361"/>
    <dbReference type="SMR" id="O83361"/>
    <dbReference type="IntAct" id="O83361">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0341"/>
    <dbReference type="EnsemblBacteria" id="AAC65326">
        <property type="protein sequence ID" value="AAC65326"/>
        <property type="gene ID" value="TP_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0341"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_12"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182179" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="481" mass="53762" checksum="4E8A736CE4700283" modified="1998-11-01" version="1">MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVPVRTPFSCQNLADAPDVVIHSAAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGIAGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCVVLNGDTFFIAETCEYRRHFLHFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAFFSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALALALSLVKKQYGEVTVEHLTALRKVLALFQGCRRRSEVLGEVRGILFMDDYGHHPTAIKKTLRGLKTFFPERRIVVDFMSHTYSRTAALLTEFAESFQDADVVILHEIYASAREVYQGEVNGEHLFELTKRKHRRVYYYEAVMQAVPFLQAELKEGDLFVTLGAGDNCKLGEVLFNYFKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83363</accession>
    <name>O83363_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TP_0343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71335">
        <property type="entry name" value="F71335"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881791.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83363">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0343"/>
    <dbReference type="EnsemblBacteria" id="AAC65331">
        <property type="protein sequence ID" value="AAC65331"/>
        <property type="gene ID" value="TP_0343"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75541">
        <property type="protein sequence ID" value="AGN75541"/>
        <property type="gene ID" value="TPANIC_0343"/>
    </dbReference>
    <dbReference type="GeneID" id="57878873"/>
    <dbReference type="KEGG" id="tpa:TP_0343"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.341"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_2_0_12"/>
    <dbReference type="OMA" id="WNNAIME"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="46"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAC65331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31719" checksum="5D60274AA203769B" modified="1998-11-01" version="1">MVGLSQSAGDIEKFQNAILDFYAQQGRDFPWRSTCDAYAILVSEFMLQQTQTERVCPKYAEWLHRFPSLESLACAPFAHVLQAWIGLGYNRRARFLHQSAKLIVERYCAVVPDDPSELKKLPGVGDYTAAAVACFAYNKATVFLETNIRAVFIRFFFPDTHQVSDRELLSLVRCTLYEENPRRWYYALMDYGAVLKRKITNPNRRSKHYVKQSPFEGSLRQVRGAVLREISGMQHAVREKTLFAKLSFEHERLSRALDSLVSEGLVVKTEAGYSIAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83372</accession>
    <name>RNH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease H</fullName>
            <shortName>RNase H</shortName>
            <ecNumber>3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rnhA</name>
        <name type="ordered locus">TP_0353</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71333">
        <property type="entry name" value="G71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881801.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0353"/>
    <dbReference type="EnsemblBacteria" id="AAC65340">
        <property type="protein sequence ID" value="AAC65340"/>
        <property type="gene ID" value="TP_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0353"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_0_12"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195412" description="Ribonuclease H">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="169" mass="18186" checksum="164311053632B047" modified="1998-11-01" version="1">MNAHAALTLYTDGACLGNPGPGGWAFALVPSDVPFLETGQXAPEAAAFTRSGSAYPSTNNRMELCAVINALQEAHGRAAEAVVVVTDSQYVRKGITQWIHTWKHNGWKTAAKQPVKNKDLWEALSALADALSVEWRWVKGHAGDPYNELCDRLATDAARRAAQSTADCP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O83401</accession>
    <name>MURF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>UDP-MurNAc-pentapeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murF</name>
        <name type="ordered locus">TP_0386</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71331">
        <property type="entry name" value="D71331"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881834.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83401"/>
    <dbReference type="SMR" id="O83401"/>
    <dbReference type="IntAct" id="O83401">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0386"/>
    <dbReference type="EnsemblBacteria" id="AAC65370">
        <property type="protein sequence ID" value="AAC65370"/>
        <property type="gene ID" value="TP_0386"/>
    </dbReference>
    <dbReference type="GeneID" id="57878912"/>
    <dbReference type="KEGG" id="tpa:TP_0386"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_4_0_12"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000101707" description="UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <sequence length="459" mass="50235" checksum="23EA5571ED95F332" modified="1998-11-01" version="1">MLLSFDEVCAAVQGARVCDARGARGFDGVSFDSRAVVPRDLFIPLRGAHVDGHTFVEEALQKGAVATLIDQRYPHAGEYVAWCTRFGAACIAVHDTLRALQDLASFYCKKFPALIRIGITGSSGKTTVKEMARAVFSERYRVVATPGNLNSEIGLPQSLFFVRAEHEVGIFELGMNRRGEMRTLAQILVPHYAIITNVGCAHVGILGTQQAIAEEKKEIFSQFTEHSVGFVPDDAYRVFLSNIPYGRVVVYDQGGRGLATEVIDEGLRGSRVLYQGRWIRVPLPGVHNAKNALAVIALAAQVGLPAEEIQRGMERVKPPFGRSHVVCASLTFLLDCYNANPDSMAAALHLCAHISAVSKVYVLGDMGELGVTAAEAHYRVCVLAAASDARAVYVFGPEFCRAVRKVSWGRKRVYAFALEELSALQETLDAQLRRGDFVLVKGSRSVALERLEPLLRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83410</accession>
    <name>O83410_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ordered locus">TP_0395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71332">
        <property type="entry name" value="E71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881843.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83410">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0395"/>
    <dbReference type="EnsemblBacteria" id="AAC65379">
        <property type="protein sequence ID" value="AAC65379"/>
        <property type="gene ID" value="TP_0395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75589">
        <property type="protein sequence ID" value="AGN75589"/>
        <property type="gene ID" value="TPANIC_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0395"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.395"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_12"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAC65379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33965" checksum="62314F3EC6DD4F03" modified="1998-11-01" version="1">MSNEQFTQYLEYLFRVRRLSAHTVSAYARDLNLFERWLQHAQRACARVTVSDMRLFVCELGRRGLSAASINRVLSVVRGFYVFAKKKHWCADNPARLVRNIKGPSKLPRFMFPPQAKAFYTLPSRTDILWQERDAALFAMLYSTGCRVSEIAALSLKDVHPHLSSAIVRGKGDRERTVFIAPFAQNFLHVYMQARAQRCARYASCTPALFVNQRGRSLSVRGIQYLVSRYVLLAQDVHALSPHAFRHSFASTLIRRGADVRVAQELLGHASVSTTQRYVHVTSEQLQDLYHRAHPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83415</accession>
    <name>O83415_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TP_0400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71328">
        <property type="entry name" value="G71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881848.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83415">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0400"/>
    <dbReference type="EnsemblBacteria" id="AAC65388">
        <property type="protein sequence ID" value="AAC65388"/>
        <property type="gene ID" value="TP_0400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75594">
        <property type="protein sequence ID" value="AGN75594"/>
        <property type="gene ID" value="TPANIC_0400"/>
    </dbReference>
    <dbReference type="GeneID" id="57878926"/>
    <dbReference type="KEGG" id="tpa:TP_0400"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.400"/>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047835_1_1_12"/>
    <dbReference type="OMA" id="QVRPFEF"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 10" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="13">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="12">
        <location>
            <begin position="133"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="11">
        <location>
            <begin position="235"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAC65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="352" mass="39822" checksum="1DA9CC7E4FBE2794" modified="1998-11-01" version="1">MAVTSVKDKLATGEKKQRDIKSLNGRQKAAIFLVSIGEEISAKVMGELKEDEIEKLVFEIARTESVDAELKDAVLEEFQELMTAQNFITSGGIDYARGLLEKSLGSQKAIEIINRLTSSLQVRPFDFIRRTDPTHLLNFIQQEHPQTIALILAYLEPNKASVILQNLPDEIQSDVARRIATMDRTSPDVLREVERVLEKKLSTLSSEDYTAAGGVQNIVDILNLVDRSSEKSIVEALEDEDPDLAEEIKKRMFVFEDIVMLDDRAIQKVLREVNMEELAKALKVVDTEVQDKIFRNMSKRAGSMLKEEMEYMGPTRLKDVEEAQQKVVSIIRHLEDSGDIVIARSEEDEMIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83419</accession>
    <name>Y404_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0404</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0404</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71329">
        <property type="entry name" value="C71329"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881852.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83419"/>
    <dbReference type="SMR" id="O83419"/>
    <dbReference type="IntAct" id="O83419">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0404"/>
    <dbReference type="EnsemblBacteria" id="AAC65395">
        <property type="protein sequence ID" value="AAC65395"/>
        <property type="gene ID" value="TP_0404"/>
    </dbReference>
    <dbReference type="GeneID" id="57878930"/>
    <dbReference type="KEGG" id="tpa:TP_0404"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_4_12"/>
    <dbReference type="OMA" id="FCNTYLV"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202248" description="Uncharacterized protein TP_0404">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <sequence length="177" mass="19491" checksum="A9395B74FA052F93" modified="1998-11-01" version="1">MKVYIHPAEQHTQRTSYLLCNLSLNEALLIDAGHVSTHLIHTIEKNSCTLTAVFLTRTDDATQAGVRTLLRVYSPHIFCGEKCWNAHESTLLQGDCSLNCAGFTVTCFASPAYGCYLYRIAHLAFTGDLCSAGYEEAGNEADTILERACTAHETLILFHGHGPPSSYTRARTQRASH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83428</accession>
    <name>O83428_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71327">
        <property type="entry name" value="C71327"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881861.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83428">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0413"/>
    <dbReference type="EnsemblBacteria" id="AAC65401">
        <property type="protein sequence ID" value="AAC65401"/>
        <property type="gene ID" value="TP_0413"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75608">
        <property type="protein sequence ID" value="AGN75608"/>
        <property type="gene ID" value="TPANIC_0413"/>
    </dbReference>
    <dbReference type="GeneID" id="57878939"/>
    <dbReference type="KEGG" id="tpa:TP_0413"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.413"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032204_0_0_12"/>
    <dbReference type="OMA" id="EANLTEM"/>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="3">
        <location>
            <begin position="366"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="632" mass="70064" checksum="85FC34E63DBB0F97" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83451</accession>
    <name>Y437_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0437</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0437</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71323">
        <property type="entry name" value="E71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881885.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83451"/>
    <dbReference type="IntAct" id="O83451">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0437"/>
    <dbReference type="EnsemblBacteria" id="AAC65435">
        <property type="protein sequence ID" value="AAC65435"/>
        <property type="gene ID" value="TP_0437"/>
    </dbReference>
    <dbReference type="GeneID" id="57878961"/>
    <dbReference type="KEGG" id="tpa:TP_0437"/>
    <dbReference type="eggNOG" id="ENOG502ZYHU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143566_1_0_12"/>
    <dbReference type="OMA" id="FSHVRLY"/>
    <dbReference type="OrthoDB" id="1569941at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202255" description="Uncharacterized protein TP_0437">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <sequence length="176" mass="19893" checksum="F3EB35CF29CD37D0" modified="1998-11-01" version="1">MIQTLVLRDTPRLESCRRGGFAMKFSTRCLRLVLCASAVALSAQDASDTAGRVLEPPPPGLTESNSSRMYYVNLPVVKVFSHRLGYRVIYRRANFEMAEIYLPSAWFSPRVGKALLRHAPVRVDPYLSFFMEGNTLTYVKLTLPRSLSSPVWGTLKSPSEYDDKFDVQFQSPEFSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83455</accession>
    <name>NADK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD kinase</fullName>
            <ecNumber evidence="1">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadK</name>
        <name type="ordered locus">TP_0441</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71324">
        <property type="entry name" value="A71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881889.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83455"/>
    <dbReference type="SMR" id="O83455"/>
    <dbReference type="IntAct" id="O83455">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0441"/>
    <dbReference type="EnsemblBacteria" id="AAC65428">
        <property type="protein sequence ID" value="AAC65428"/>
        <property type="gene ID" value="TP_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0441"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_0_12"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000120682" description="NAD kinase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <sequence length="305" mass="32634" checksum="4885B3DDE3C1CE58" modified="1998-11-01" version="1">MSSRVCPQRPVAKSSGDAKVLLIVSTYKPRAAVLAADVVNFLSIRGFQCHTIEYDGLNKESCARAGYMFAVSIGGDGTTLFAARCASPSGIPILAINLGRFGFIAPIEPRYWQQALSDYLAGGVRPAERALISCTVTRAGKEIASCLALNDVVLSSGRVARLTRAEVCFNDISFGVYEADGIILATPTGSTAYSAACGGPILDPDLDAFVLTPISALCLSNRPVVVPSSGVVRIKVLSMRHKETVLSVDGHELCTLQEEDQLLASRSSCSARLVFCTPHVFYHALCSKLAWSGSIFSRRGRRHDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83465</accession>
    <name>Y451_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0451</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0451</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71322">
        <property type="entry name" value="D71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881899.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83465"/>
    <dbReference type="IntAct" id="O83465">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0451"/>
    <dbReference type="EnsemblBacteria" id="AAC65442">
        <property type="protein sequence ID" value="AAC65442"/>
        <property type="gene ID" value="TP_0451"/>
    </dbReference>
    <dbReference type="GeneID" id="57879576"/>
    <dbReference type="KEGG" id="tpa:TP_0451"/>
    <dbReference type="HOGENOM" id="CLU_209906_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202256" description="Uncharacterized protein TP_0451">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <sequence length="60" mass="6625" checksum="A643A27D5E4241C8" modified="1998-11-01" version="1">MLSMQLVTVTVQGAMVADIAVAVRTAPHPFLYASVLQDSPQARKPVRETRYQKMSAFLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83468</accession>
    <name>O83468_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71322">
        <property type="entry name" value="H71322"/>
    </dbReference>
    <dbReference type="IntAct" id="O83468">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0455"/>
    <dbReference type="EnsemblBacteria" id="AAC65440">
        <property type="protein sequence ID" value="AAC65440"/>
        <property type="gene ID" value="TP_0455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75649">
        <property type="protein sequence ID" value="AGN75649"/>
        <property type="gene ID" value="TPANIC_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0455"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.455"/>
    <dbReference type="eggNOG" id="ENOG50340W9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894126_0_0_12"/>
    <dbReference type="OMA" id="IIYDYTV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503432" evidence="1">
        <location>
            <begin position="35"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="334" mass="38895" checksum="60C6784DF87E3D96" modified="1998-11-01" version="1">MPTLRWQGWRMKLKRSLIVGGGLLLCCAHGYAQAKGARASVHIAYHNRTIYFPGTHESEPIWVKVSLTNTGKDTLRFKLADDRTFSVDFSIRTMKNRALAHTDEWIRKRSTHRPVYFREISLEPGESYSFVENVKHYLDVQSAGLYFLTLLFYPELKRERTGDEDHLASNTLTLEVQPAPAAAALGALPVSPPVGEVLQPQRLSPDRVIEYVLNARQKSHWERFFLYLDLAKMLSRDAGRSRRFNAESEAGRYNMIDTYKHELRQERVDKDIAAIPVEFRIEKTVYTATDAEVRVLEWFEYRDFREKKRFTYHLSSRDGIWYVHDYVVENLGTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83493</accession>
    <name>Y480_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0480</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0480</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71319">
        <property type="entry name" value="F71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881929.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83493"/>
    <dbReference type="STRING" id="243276.TPANIC_0480"/>
    <dbReference type="EnsemblBacteria" id="AAC65469">
        <property type="protein sequence ID" value="AAC65469"/>
        <property type="gene ID" value="TP_0480"/>
    </dbReference>
    <dbReference type="GeneID" id="57879001"/>
    <dbReference type="KEGG" id="tpa:TP_0480"/>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128655_0_0_12"/>
    <dbReference type="OMA" id="EMYNNAF"/>
    <dbReference type="OrthoDB" id="2040551at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019935">
        <property type="entry name" value="CHP03546"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03546">
        <property type="entry name" value="TIGR03546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202262" description="Uncharacterized protein TP_0480">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="162" mass="18171" checksum="C38944D80AE650BB" modified="1998-11-01" version="1">MIRALFSLFRSLHANTHPADLAHAAALALALALLPRSSLLWYLLFAVCFFIRLNRGLLLLSLVLFGFVVPSFDPWLDSLGNWALCLPRLQPVYRALIEIPFVGLARFYNTMIAGGLVAGALCYLPCYALARCAVTAYRTYLYPKIHHATIFFLVRNAPLCKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83497</accession>
    <name>Y484_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0484</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0484</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71320">
        <property type="entry name" value="B71320"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881933.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83497"/>
    <dbReference type="IntAct" id="O83497">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0484"/>
    <dbReference type="EnsemblBacteria" id="AAC65473">
        <property type="protein sequence ID" value="AAC65473"/>
        <property type="gene ID" value="TP_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0484"/>
    <dbReference type="eggNOG" id="COG4254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409343_0_0_12"/>
    <dbReference type="OMA" id="MPANDAV"/>
    <dbReference type="OrthoDB" id="610676at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202265" description="Uncharacterized protein TP_0484">
        <location>
            <begin position="1"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="671" mass="75838" checksum="FE746C96BF27B661" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>O83508</accession>
    <name>Y495_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0495</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0495</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71316">
        <property type="entry name" value="C71316"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83508"/>
    <dbReference type="IntAct" id="O83508">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65490">
        <property type="protein sequence ID" value="AAC65490"/>
        <property type="gene ID" value="TP_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0495"/>
    <dbReference type="HOGENOM" id="CLU_3141875_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202267" description="Uncharacterized protein TP_0495">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <sequence length="49" mass="5166" checksum="01E3617D5E5DB39C" modified="1998-11-01" version="1">MLLMRLAVPFCRQNAVSSYLALSPLPKGGIFSVALAVSGTAESRCLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83512</accession>
    <name>O83512_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein (MreD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71316">
        <property type="entry name" value="G71316"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881948.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83512">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0499"/>
    <dbReference type="EnsemblBacteria" id="AAC65486">
        <property type="protein sequence ID" value="AAC65486"/>
        <property type="gene ID" value="TP_0499"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75689">
        <property type="protein sequence ID" value="AGN75689"/>
        <property type="gene ID" value="TPANIC_0499"/>
    </dbReference>
    <dbReference type="GeneID" id="57879020"/>
    <dbReference type="KEGG" id="tpa:TP_0499"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.495"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132534_2_2_12"/>
    <dbReference type="OMA" id="FFNTRIF"/>
    <dbReference type="OrthoDB" id="1487171at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017225">
        <property type="entry name" value="Cell_shape_determin_MreD_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037497">
        <property type="entry name" value="MreD_Clostridium/Treponema_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18818" checksum="998ED0AF944DA3D6" modified="1998-11-01" version="1">MIRLIAWSVGTSFLFSIVEMAVFVHVSYLSIMPDLVLLVVLFTSIHNGVVAGIWTGFIAGIIFDFLSISPFGLHSFVFTTIGFMVGKVQGRYHIDRVFAPAVLAGFAMIFKVGLVLVLRGVFGPNIQVYSVFSRQLWIEMTLNIVFVPFVFGLLNMFPTTFLYKRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83531</accession>
    <name>O83531_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPK_catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71315">
        <property type="entry name" value="E71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881967.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83531">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0518"/>
    <dbReference type="EnsemblBacteria" id="AAC65506">
        <property type="protein sequence ID" value="AAC65506"/>
        <property type="gene ID" value="TP_0518"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75707">
        <property type="protein sequence ID" value="AGN75707"/>
        <property type="gene ID" value="TPANIC_0518"/>
    </dbReference>
    <dbReference type="GeneID" id="57879041"/>
    <dbReference type="KEGG" id="tpa:TP_0518"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.513"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_1_12"/>
    <dbReference type="OMA" id="PRDKDYT"/>
    <dbReference type="OrthoDB" id="1628990at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_catalytic" evidence="5">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="230" mass="25567" checksum="42FBAC7162ACF431" modified="1998-11-01" version="1">MKRALIITGGEYAPYEFVQYYLPAYDLLIAADSGLDTALQFGLVPDFVIGDMDSVKDNLFIQACDKTRTHLFPRDKDFTDTELAVTLAHQLGSDDLSIVGGGGGRADHFLYFMRLFAAPLSPRLWLYRHGLGYCFGEGCVTQQLCIGGVDNTSFSFFPVGDATDYSLSSEGLHWPLDGVPWHTHVSMSNRSSAPVVRVEAHRGRFLLFLSPLGRYTIDHHERGIACTHRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83547</accession>
    <name>SECG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">secG</name>
        <name type="ordered locus">TP_0536</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71311">
        <property type="entry name" value="E71311"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881983.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83547"/>
    <dbReference type="SMR" id="O83547"/>
    <dbReference type="STRING" id="243276.TPANIC_0536"/>
    <dbReference type="EnsemblBacteria" id="AAC65529">
        <property type="protein sequence ID" value="AAC65529"/>
        <property type="gene ID" value="TP_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0536"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_0_0_12"/>
    <dbReference type="OMA" id="STFWNDD"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000157251" description="Probable protein-export membrane protein SecG">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="133" mass="14279" checksum="43557E45AF1D6DAB" modified="1998-11-01" version="1">MAVLSVMILSLLVVVCLLVVTLVLLQTEEGDGLGGMFSGGSRSAFGSRSASVLTKTSYVMVGLFFGLTFFLALLNRAPDDTGLQKAAQQKQAETAVEWWKHPPKKVLVLQRLLSLLVLPQEFLGLWGSGSSVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83550</accession>
    <name>Y539_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0539</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0539</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71311">
        <property type="entry name" value="H71311"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881986.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83550"/>
    <dbReference type="IntAct" id="O83550">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0539"/>
    <dbReference type="EnsemblBacteria" id="AAC65530">
        <property type="protein sequence ID" value="AAC65530"/>
        <property type="gene ID" value="TP_0539"/>
    </dbReference>
    <dbReference type="GeneID" id="57879581"/>
    <dbReference type="KEGG" id="tpa:TP_0539"/>
    <dbReference type="HOGENOM" id="CLU_2703746_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202272" description="Uncharacterized protein TP_0539">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <sequence length="73" mass="7878" checksum="B901D6AAC2B68400" modified="1998-11-01" version="1">MTSLQVLSIISSFLTQGLPHPPHVAADSHYISKKDSISASVGRLTSLLPCLCALHAYGVGHRPFVIVDIFYAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83554</accession>
    <name>RUVA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">TP_0543</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71312">
        <property type="entry name" value="D71312"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881990.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83554"/>
    <dbReference type="SMR" id="O83554"/>
    <dbReference type="IntAct" id="O83554">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0543"/>
    <dbReference type="EnsemblBacteria" id="AAC65527">
        <property type="protein sequence ID" value="AAC65527"/>
        <property type="gene ID" value="TP_0543"/>
    </dbReference>
    <dbReference type="GeneID" id="57879067"/>
    <dbReference type="KEGG" id="tpa:TP_0543"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_2_0_12"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000094703" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="227" mass="24399" checksum="6B66933517D37156" modified="1998-11-01" version="1">MFESISGILTLHERERLCVEVHGIEWEIAVSAYSSAAFGEVGSHVKVFTWLYHREDALRLFGFSNVQERTLFLSLTKVEGIGPKQALKVLSSISSQALCAALDTGDLCALQRIPGIGKKTAQRMLLALKGTLALTDAASCAQSQTDDRAAHPSNLGCAPHAREIEDLVTALVQMGYDRKMAAEVIAQESAALCSVGRSLYEEEATVLKRAILALSIAHPHAVAPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83555</accession>
    <name>O83555_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71312">
        <property type="entry name" value="E71312"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881991.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83555">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0544"/>
    <dbReference type="EnsemblBacteria" id="AAC65531">
        <property type="protein sequence ID" value="AAC65531"/>
        <property type="gene ID" value="TP_0544"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75731">
        <property type="protein sequence ID" value="AGN75731"/>
        <property type="gene ID" value="TPANIC_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0544"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.582"/>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003608_1_1_12"/>
    <dbReference type="OMA" id="LWVTVKP"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="304"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="622" mass="68206" checksum="9C4158D98051FC5C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83560</accession>
    <name>O83560_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase (ClpC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71311">
        <property type="entry name" value="A71311"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881996.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0549"/>
    <dbReference type="EnsemblBacteria" id="AAC65534">
        <property type="protein sequence ID" value="AAC65534"/>
        <property type="gene ID" value="TP_0549"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75736">
        <property type="protein sequence ID" value="AGN75736"/>
        <property type="gene ID" value="TPANIC_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0549"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.546"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_12"/>
    <dbReference type="OMA" id="HDKFLPD"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="6">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="814" mass="91582" checksum="997545B16F9ACFD4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83570</accession>
    <name>THII_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiI</name>
        <name type="ordered locus">TP_0559</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71310">
        <property type="entry name" value="C71310"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882006.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83570"/>
    <dbReference type="SMR" id="O83570"/>
    <dbReference type="IntAct" id="O83570">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0559"/>
    <dbReference type="EnsemblBacteria" id="AAC26563">
        <property type="protein sequence ID" value="AAC26563"/>
        <property type="gene ID" value="TP_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0559"/>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_0_12"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="OrthoDB" id="773697at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154882" description="Probable tRNA sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <sequence length="401" mass="44640" checksum="BFFA2F544000EE49" modified="1998-11-01" version="1">MVNGSTQYLAHVGELSLKKGNRRQFEVQLERNLTLMLRSINPHVTVRAGRLYLSVPASFEAQTTAEQALSYLLGITGWAAATACPKTMEAITRCAHAEATLAAREGKRTFRIEARRADKRFCRTSSEIAREVGAVIHQSGALSVDLHHPDVVIFIEVREREAFLYGARRRGLRGLPCGVSGRGLLLLSGGIDSPVAGYRMLSRGMHIDCLYFHSYPYTPPEAQKKVEDLAKVLARYGLSTTLTVVSLTDIQKQLQTHAPAPSLTLLLRMCMMRIAEHVAREQRARCLITGESLAQVASQTLENLTVTSACTHLPIFRPLIGADKEDIIRTATEIGTYAISIRPYEDCCTLFAPKHPVLRPEVEEMQKQYQSLMLGPLLEDAFRTRKRTRIYGNYGVQESGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83602</accession>
    <name>Y593_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0593</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0593</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71306">
        <property type="entry name" value="B71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882039.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83602"/>
    <dbReference type="IntAct" id="O83602">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0593"/>
    <dbReference type="EnsemblBacteria" id="AAC65571">
        <property type="protein sequence ID" value="AAC65571"/>
        <property type="gene ID" value="TP_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0593"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464544_0_0_12"/>
    <dbReference type="OrthoDB" id="1217774at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202282" description="Uncharacterized protein TP_0593">
        <location>
            <begin position="1"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="677" mass="75493" checksum="0583E109B453053C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83609</accession>
    <name>Y600_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative zinc metalloprotease TP_0600</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0600</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71304">
        <property type="entry name" value="B71304"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882046.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83609"/>
    <dbReference type="SMR" id="O83609"/>
    <dbReference type="IntAct" id="O83609">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0600"/>
    <dbReference type="EnsemblBacteria" id="AAC65573">
        <property type="protein sequence ID" value="AAC65573"/>
        <property type="gene ID" value="TP_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0600"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_0_0_12"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000088474" description="Putative zinc metalloprotease TP_0600">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ">
        <location>
            <begin position="200"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="450" mass="49565" checksum="7692F518985D37E7" modified="1998-11-01" version="1">MIKIIIGVVVLGIVVLFHELGHFVAALWCRVEVLSFSVGMGPVLFRKKFGKTEYRLSMLPLGGYCGMKGEQAFQTALDQKLSRIPVEPGSLYAVGPLKRMGIAFAGPLANVLMAVMVLALVSALGSRVHTFGNRISPVYVYDSSDNSPARRVGLQDGDTILRIGDQPIRYFSDIQKIVSQHAQRALPFVIERRGQLMHVTITPDRDAHTGMGRVGIYHYVPLVVAAVDAHGAASRAGLEPEDKILAVAGRRVQHAVQLLALLKEFRKKSVVLTVLRSGKRRYHTIALVRTENGAIDVGIEWKAHTVVIPGTSFFASVRAGIAETLRMCVLTVKGIGMLFRGLQFQQAISGPLRITHVIGDVAQHGFQESFLTGLSQLCEFVALVCVSLFIMNLLPIPILDGGLILFACVELFMQRSIHPRVLYYLQFVGFAFVALIFLCAFWNDVNFLFH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83614</accession>
    <name>EFTS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor Ts</fullName>
            <shortName>EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tsf</name>
        <name type="ordered locus">TP_0605</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71304">
        <property type="entry name" value="G71304"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882051.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83614"/>
    <dbReference type="SMR" id="O83614"/>
    <dbReference type="IntAct" id="O83614">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0605"/>
    <dbReference type="EnsemblBacteria" id="AAC65578">
        <property type="protein sequence ID" value="AAC65578"/>
        <property type="gene ID" value="TP_0605"/>
    </dbReference>
    <dbReference type="GeneID" id="57879128"/>
    <dbReference type="KEGG" id="tpa:TP_0605"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_0_12"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161225" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="290" mass="31783" checksum="14B9386AF3E42884" modified="1998-11-01" version="1">MEIAARDVKSLRDKTGAGMMECKRALQECAGDALCAEKYLKERGLAAIENRRGRATAEGVIVIKARHAEGAACGASAVAMVELVCETDFVAKNAEFIALAERIAQAVLEHAYTEVNQVLRDMVVDLATRVRENMSLTRLALLRAGSAGAGQYLSHYVHPDKKTGVVLSFSSDAPDVFLRSDVRAFAYDCCLHAAAYTPRYVRAEDVPAEYVREQREVFQAHVASLQKPAHVKESIVQGKLEKHLAEICFLKQPFVKDDKLSVEKKMAEVGARAGGALRFTQALIYQLGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O83620</accession>
    <name>O83620_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71302">
        <property type="entry name" value="H71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882057.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83620">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0611"/>
    <dbReference type="EnsemblBacteria" id="AAC65587">
        <property type="protein sequence ID" value="AAC65587"/>
        <property type="gene ID" value="TP_0611"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75792">
        <property type="protein sequence ID" value="AGN75792"/>
        <property type="gene ID" value="TPANIC_0611"/>
    </dbReference>
    <dbReference type="GeneID" id="57879134"/>
    <dbReference type="KEGG" id="tpa:TP_0611"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.603"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_12"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="259" mass="28256" checksum="F902D21D7ADAB213" modified="1998-11-01" version="1">MPTLLDIRDLCMSIADRPILKSLNLTLNTGEVHAVMGPNGAGKSTLAGTIVGNPHCTIERGEIYFQGQCINDVPVYERARRGIFLSFQTPEEVPGLSVEEFLRAAKEAVLGTKVSVLDFHTQLRAKLARLRISEAYASRGLNVGFSGGEKKKNEILQLAVLEPKLAILDETDSGLDVDATRIVFEGIDDIRTPDMGFLIITHHREVLEYIKPDVVHILVDGTIVKTGDVSLVHYVVEHGYADFATPRAGEQGGTPVSPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83635</accession>
    <name>SBCC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Nuclease SbcCD subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">sbcC</name>
        <name type="ordered locus">TP_0627</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SbcC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71302">
        <property type="entry name" value="D71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882073.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83635"/>
    <dbReference type="IntAct" id="O83635">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0627"/>
    <dbReference type="PRIDE" id="O83635"/>
    <dbReference type="EnsemblBacteria" id="AAC65599">
        <property type="protein sequence ID" value="AAC65599"/>
        <property type="gene ID" value="TP_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0627"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_2_1_12"/>
    <dbReference type="OMA" id="ISHVQEM"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004592">
        <property type="entry name" value="SbcC_gammaproteobac_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00618">
        <property type="entry name" value="sbcc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105868" description="Nuclease SbcCD subunit C">
        <location>
            <begin position="1"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="521"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="624"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="698"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1047" mass="118647" checksum="D900680131EA3F5D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O83647</accession>
    <name>SYH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Histidine--tRNA ligase</fullName>
            <ecNumber>6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Histidyl-tRNA synthetase</fullName>
            <shortName>HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hisS</name>
        <name type="ordered locus">TP_0641</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71298">
        <property type="entry name" value="H71298"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882086.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83647"/>
    <dbReference type="SMR" id="O83647"/>
    <dbReference type="IntAct" id="O83647">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0641"/>
    <dbReference type="EnsemblBacteria" id="AAC65615">
        <property type="protein sequence ID" value="AAC65615"/>
        <property type="gene ID" value="TP_0641"/>
    </dbReference>
    <dbReference type="GeneID" id="57879166"/>
    <dbReference type="KEGG" id="tpa:TP_0641"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_12"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136286" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="442" mass="50199" checksum="079E2F89784D632B" modified="1998-11-01" version="1">MRVGSAVSPKVLKGFRDLLPDEEIERALLVEKLTVALRQMGFVPIDTPALEYTEVLLRKSEGDTEKQMFRFVDKGGRDVALRFDLTVPLARFVATHYARLYFPFKRYHFAKVWRGEKPQMGRYREFTQCDFDIVGSDSVCADFEILKSIRHMLYMAGAEHIRIHVAHRGLFDRFLRALSLSDQAEHILRIIDKRAKMAPHVLTAQLESLCDPVRVQKIMTYVSAGEVDGVAPSFEHTLSAIETLTGGVSEESTRLRKIYELLCAVNIQSSYVFDPSITRGFDYYTGMVCETFLTQLPHIGSVCSGGRYDHLTALYMKDAVSGVGASIGLDRLYAAFQQLGMSREHVCFVQALIFCQDSALMDVYQKLCSYFAVQVATEVFPDPRKLSQQYAFAEKKGIRWGIFVEQRNAVVEDCLLVLRDLSTRKDTRLPAHEVRRRMAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83648</accession>
    <name>O83648_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase (ManB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TP_0642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71299">
        <property type="entry name" value="A71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882087.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83648">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0642"/>
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        <property type="protein sequence ID" value="AAC65616"/>
        <property type="gene ID" value="TP_0642"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75822">
        <property type="protein sequence ID" value="AGN75822"/>
        <property type="gene ID" value="TPANIC_0642"/>
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    <dbReference type="KEGG" id="tpa:TP_0642"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.635"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_0_12"/>
    <dbReference type="OMA" id="PQDNGYK"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
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    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
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    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
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        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="47"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="214"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="329"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="506"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="586" mass="65137" checksum="94E7F0F81D92421E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83656</accession>
    <name>YBEY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">TP_0650</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71300">
        <property type="entry name" value="A71300"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882095.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83656"/>
    <dbReference type="SMR" id="O83656"/>
    <dbReference type="IntAct" id="O83656">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0650"/>
    <dbReference type="EnsemblBacteria" id="AAC65623">
        <property type="protein sequence ID" value="AAC65623"/>
        <property type="gene ID" value="TP_0650"/>
    </dbReference>
    <dbReference type="GeneID" id="57879174"/>
    <dbReference type="KEGG" id="tpa:TP_0650"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_3_12"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000102558" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="160" mass="18012" checksum="053796A81A7D898F" modified="1998-11-01" version="1">MSEVNKVSVSCEGFCPPPWIGQVAPFVCAVLDSQAISHWDLSIVCCTDAFIRRLNYDYRGIDSPTDVLSFENDGEYCDDAGTRFFLAGDIIISLESVRENSERFHVAAHEEFKRVLIHGILHLSGMDHQDNSPGQEMLRLQERILAQHCRVLSSGIPWES</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83661</accession>
    <name>O83661_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter, periplasmic binding protein (PotD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2007" name="J. Mol. Biol." volume="373" first="681" last="694">
            <title>Structural and biochemical basis for polyamine binding to the Tp0655 lipoprotein of Treponema pallidum: putative role for Tp0655 (TpPotD) as a polyamine receptor.</title>
            <authorList>
                <person name="Machius M."/>
                <person name="Brautigam C.A."/>
                <person name="Tomchick D.R."/>
                <person name="Ward P."/>
                <person name="Otwinowski Z."/>
                <person name="Blevins J.S."/>
                <person name="Deka R.K."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="17868688"/>
            <dbReference type="DOI" id="10.1016/J.JMB.2007.08.018"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 25-348</scope>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71296">
        <property type="entry name" value="H71296"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882100.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="2V84">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.78 A"/>
        <property type="chains" value="A=25-348"/>
    </dbReference>
    <dbReference type="PDBsum" id="2V84"/>
    <dbReference type="SMR" id="O83661"/>
    <dbReference type="IntAct" id="O83661">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0655"/>
    <dbReference type="EnsemblBacteria" id="AAC65630">
        <property type="protein sequence ID" value="AAC65630"/>
        <property type="gene ID" value="TP_0655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75834">
        <property type="protein sequence ID" value="AGN75834"/>
        <property type="gene ID" value="TPANIC_0655"/>
    </dbReference>
    <dbReference type="GeneID" id="57879179"/>
    <dbReference type="KEGG" id="tpa:TP_0655"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.648"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_3_12"/>
    <dbReference type="OMA" id="SNWTEYM"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="BRENDA" id="7.6.2.16">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="O83661"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503426" evidence="2">
        <location>
            <begin position="30"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine-binding" evidence="1">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2V84"/>
        </source>
    </evidence>
    <sequence length="348" mass="39752" checksum="44ABD94E5D1F920B" modified="1998-11-01" version="1">MKRFCVSSSRILSLLFLSLWMGSCLQTRQDVLYLYNWTYYTPTSLIKKFEQQYNVQVVYDDYASNEDMFAKLSIGASGYDLVVPSGDFVSIMKRKHLLEKIDLSKIPNVQFIKESVRARIAYDPKMEYSVPYYLGAAGIAVNKKAVPSYARTWSIFSRKDLAYRMSMMDDMREVMGAALASLGYNVNTKNEQELAQAAILVTDHWKPNLVKFDSDGYAKSFASGDFVVAHGFAEAFFAETPEAMHEHIDFFIPQDVASPVYVDSFCIPKGARNRDLAHAFINFFLEPAHYAEFLDTFGFPSTIHREAAAYQKKTPYYSEHDLERGTLKTDVGAAIEHYNAHWNAVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83669</accession>
    <name>O83669_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71297">
        <property type="entry name" value="H71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882108.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83669">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0663"/>
    <dbReference type="EnsemblBacteria" id="AAC65636">
        <property type="protein sequence ID" value="AAC65636"/>
        <property type="gene ID" value="TP_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0663"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.704"/>
    <dbReference type="eggNOG" id="ENOG5033UVP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097187_0_0_12"/>
    <dbReference type="OMA" id="ERADNFV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006714">
        <property type="entry name" value="FlaA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04620">
        <property type="entry name" value="FlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004160290" evidence="3">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27258" checksum="86C71D313FFFCD6F" modified="1998-11-01" version="1">MKQGCFMVAGFALTCAFLVSPLAAQRSKVNYQAYFIDDFDGASEDQGLAWRAAGSKFITKGFPILKYFEGMPQAVRMAGSWQGKDKEARFIGVECKFNRQGNNWLDLIPTKGGSDYEIPLRGVVSGFDVWVWGAGYQYSLEALVRDCTGRVHTLLIGNLDFQGWKNLSVSVPTHIPQTSRYLGSAQHLSFVGFRIRTXPSERVDDFYVFFDQFKALANMHIDFYDGHELRNAQFKEEGESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83677</accession>
    <name>O83677_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">sn-1,2-diacylglycerol cholinephosphotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71296">
        <property type="entry name" value="B71296"/>
    </dbReference>
    <dbReference type="IntAct" id="O83677">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0671"/>
    <dbReference type="EnsemblBacteria" id="AAC26569">
        <property type="protein sequence ID" value="AAC26569"/>
        <property type="gene ID" value="TP_0671"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75849">
        <property type="protein sequence ID" value="AGN75849"/>
        <property type="gene ID" value="TPANIC_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0671"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.663"/>
    <dbReference type="eggNOG" id="COG5050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813633_0_0_12"/>
    <dbReference type="OMA" id="VVILEWI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="PTHR10414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC26569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="344" mass="38969" checksum="AE06243C7EA1EB3F" modified="1998-11-01" version="1">MSHITSRRSSRMKAYSYAVEDRSLLTPFLYRFCVDPLLRVVPYRVPANLITLCANACMLLAFTHAYCGSVGGTYAYWFLVPVLCIVYLVGDCLDGRQARRTGTGSPLGEYFDHCLDTSVVGLLAGIFVLAFRIREPFLLTCIFFVPAFVQISTLWEKLHRGVMVFARIGSNEMVVLTTLGAYAGSFETLRALFLTPLFFSCTPAQVCVSVLSTGVCIFSCAVFWRMRVFSCALFLHLSLFFFLCVFSSTYFPTQIGYITALCTLYHMRYAERLLRVIVQGEGTARVEVLVPLLCGVLFLFPQTSFWVQRAQCSILALEVGVHFVRFVYAHRCYWHWLNPLPTQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83681</accession>
    <name>Y675_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0675</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0675</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71294">
        <property type="entry name" value="C71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882120.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83681"/>
    <dbReference type="IntAct" id="O83681">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0675"/>
    <dbReference type="EnsemblBacteria" id="AAC65651">
        <property type="protein sequence ID" value="AAC65651"/>
        <property type="gene ID" value="TP_0675"/>
    </dbReference>
    <dbReference type="GeneID" id="57879199"/>
    <dbReference type="KEGG" id="tpa:TP_0675"/>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057525_0_1_12"/>
    <dbReference type="OMA" id="VYLELDM"/>
    <dbReference type="OrthoDB" id="1991552at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202300" description="Uncharacterized protein TP_0675">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="332" mass="37234" checksum="2B53708FC8873143" modified="1998-11-01" version="1">MNTTGRPVFPLLRRTVLKRCSLCATRCAIVFLCVLLILPFLSCCTSLSRGALPSLISHKERMFWEIRGPQGSVYILGTISVGSEKLLHFQDKILDVFDSASRLYAELGSEDIKNFASVLQRRMLHGMLEQENAAPTLSSLSREELEMLRSTLGDDMHTLSRFEPWVMRVALYQALIAHTKLDSGKNIEAFLYQRAGNRKILGLDSIQKHLNMLSFGNREEQITLLRALIALGKSPADFKGRLGALVRSYLSNDKTALGRVSTELDALVTKDAAGGLHRRYVAEIAASRRAAWAEEFYRLSLQHGITFVFASAGHFCGPESVFDIMRKRRLLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O83690</accession>
    <name>RECA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">TP_0692</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71293">
        <property type="entry name" value="A71293"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882137.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0692"/>
    <dbReference type="EnsemblBacteria" id="AAC65660">
        <property type="protein sequence ID" value="AAC65660"/>
        <property type="gene ID" value="TP_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0692"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_12"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000122886" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="407" mass="44216" checksum="D9A9861F7B2FF9D1" modified="1998-11-01" version="1">MSKALKGDVPVSSSFEEKMKALEAARLQIEKQFGQGSLMKLGKDDAVQGVEVIPTGNILLDEALGIGGYPRGRIIEIFGPESSGKTTLALHAVAEAQKRGGIAAFIDAEHALDPQYAKDLGVSVGDLWISQPDTGEQALEIAESLVRSGAVDIIVVDSVAALTPQAEIQGDMGDAHVGLIARLMSQALRKLTSIINKSKCTLIFINQLRMKIGIMFGNPETTTGGIALKFYSSVRIEVRKVETLSRGDEEAWGNKVRIRIVKNKMAPPFRKVETEILFGKGFSAFSCLLDAAVKQEIIEKKGAWYAYREEKIGQGRDNAVGFLQQNMDITLEIERAVRTKLFPKQAFISSFQEHRPALSLEASPEESDAKTLRRXASRGAGASSSRVQEGSAANDHFQDESTTAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83700</accession>
    <name>O83700_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71289">
        <property type="entry name" value="B71289"/>
    </dbReference>
    <dbReference type="IntAct" id="O83700">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65671">
        <property type="protein sequence ID" value="AAC65671"/>
        <property type="gene ID" value="TP_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0702"/>
    <dbReference type="HOGENOM" id="CLU_1509973_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="178" mass="19381" checksum="F662561EB81EEF23" modified="1998-11-01" version="1">MTSPQTRAFLGPFRQPVESRRCTSVFGQARVFVYTDGTRSAQYHWGKDFGVPVGTAVYAAGTGRVVLAEQRTTTGWSVVLEHAPGLYTAYYHLNELLVKKDTYVSTGTLIARSGTTGFSTGPHVHWEARINSTPIDPECLLAPPFLTHLPKNALRKLQPTGETQPGTPLPKDTNGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83722</accession>
    <name>O83722_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
            <ecNumber evidence="2">3.6.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71286">
        <property type="entry name" value="A71286"/>
    </dbReference>
    <dbReference type="IntAct" id="O83722">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0740"/>
    <dbReference type="EnsemblBacteria" id="AAC65709">
        <property type="protein sequence ID" value="AAC65709"/>
        <property type="gene ID" value="TP_0740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75914">
        <property type="protein sequence ID" value="AGN75914"/>
        <property type="gene ID" value="TPANIC_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0740"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.729"/>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089580_1_2_12"/>
    <dbReference type="OMA" id="ILTRNWA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="4">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="188" mass="20548" checksum="E475654364DBE71A" modified="1998-11-01" version="1">MDAYARAVLSPPRYEHSRRVAEFGCMLVRRYALEAQLEPHVYCAGIAHDMCREHSEVFLLRAAACDGFPIDVTERGTPLLLHGRAAACVLAQEFGVQDEVLLSAVRWHTFGCEDFGVLGKILFISDKIEPARAWAASLRGAVSTLTLDALAAKVVSASIVCAERKRTTPHPRTCAMLRALGKDVSQPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83725</accession>
    <name>RL27_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmA</name>
        <name type="ordered locus">TP_0743</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71286">
        <property type="entry name" value="D71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882188.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83725"/>
    <dbReference type="SMR" id="O83725"/>
    <dbReference type="IntAct" id="O83725">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0743"/>
    <dbReference type="EnsemblBacteria" id="AAC65717">
        <property type="protein sequence ID" value="AAC65717"/>
        <property type="gene ID" value="TP_0743"/>
    </dbReference>
    <dbReference type="GeneID" id="57879267"/>
    <dbReference type="KEGG" id="tpa:TP_0743"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_12"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000181197" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="87" mass="9415" checksum="4DD438B22F243DE4" modified="1998-11-01" version="1">MARKRGGSGSKNGRDSNPKYLGVKLFGGQHARAGSILVRQRGTRIHPGENVGRGKDDTLFALAPGVVTYLQRKGRRLVSVCVENRPS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83735</accession>
    <name>MIAB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="1">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaB</name>
        <name type="ordered locus">TP_0754</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71284">
        <property type="entry name" value="E71284"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882199.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83735"/>
    <dbReference type="SMR" id="O83735"/>
    <dbReference type="IntAct" id="O83735">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0754"/>
    <dbReference type="EnsemblBacteria" id="AAC65721">
        <property type="protein sequence ID" value="AAC65721"/>
        <property type="gene ID" value="TP_0754"/>
    </dbReference>
    <dbReference type="GeneID" id="57879277"/>
    <dbReference type="KEGG" id="tpa:TP_0754"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_12"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000141756" description="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="148"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="456" mass="52572" checksum="6270950A1C601B5E" modified="1998-11-01" version="1">MTYFFETYGCQMNVAESASVEQLLLARGWTKAVDAQTCDVLIINTCSVRITAETRVFGRLGLFSSLKKKRAFFIILMGCMAQRLHDKIQQQFPRIDYVVGTFAHARFESIFQEIEQKLTQKDYRFEFISERYREHPVSGYRFFASSYSEGSFQSFIPIMNGCNNFCSFCIVPYVRGREISRDLDAILQEVDVLSEKGVREITLLGQNVNSYRGRDREGNIVTFPQLLRHLVRRCEVKDQIKWIRFVSSHPKDLSDDLIATIAQESRLCRLVHLPVQHGANGVLKRMRRSYTREQYLSLVGKLKASVPNVALSTDILIGFPGETEEDFEQTLDLMREVEFDSAFMYHYNPREGTPAYDFPDRIPDATRIARLQRVIALQMSTTLKKMRARVGKTLPVLVESRSRNNPEELFGHTELGEMTVLEGKVDPTYIGRFVDVQVKEVRGRTLRAHLVQERAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83740</accession>
    <name>Y759_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0759</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0759</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71285">
        <property type="entry name" value="B71285"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83740"/>
    <dbReference type="IntAct" id="O83740">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65731">
        <property type="protein sequence ID" value="AAC65731"/>
        <property type="gene ID" value="TP_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0759"/>
    <dbReference type="HOGENOM" id="CLU_3318672_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202316" description="Uncharacterized protein TP_0759">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <sequence length="39" mass="4379" checksum="BB5132E7F8975BA8" modified="1998-11-01" version="1">MLMQPLTFLTCVYLWYSAALCVEVKIVRTDLLSSASVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O83765</accession>
    <name>O83765_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TP_0786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71280">
        <property type="entry name" value="A71280"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882231.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83765">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0786"/>
    <dbReference type="EnsemblBacteria" id="AAC65755">
        <property type="protein sequence ID" value="AAC65755"/>
        <property type="gene ID" value="TP_0786"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75958">
        <property type="protein sequence ID" value="AGN75958"/>
        <property type="gene ID" value="TPANIC_0786"/>
    </dbReference>
    <dbReference type="GeneID" id="57879307"/>
    <dbReference type="KEGG" id="tpa:TP_0786"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.772"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAC65755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="237" mass="26524" checksum="36AA092216F2537B" modified="1998-11-01" version="1">MAAALNKTFRTRHVVHDVSFSVHQAEIVGLFGPNGAGKSVSFSMVMGLCRPDSGRVLLDCTDITPLPIHVRARMGVSYVPQEPSIFRKITVEANVRAIMQMRRDLSYTEQTERCEALLKAFQLTHVRNQRADTLSGGERKRVEIARALTVNPRFLIFDEPFSGIDPCAVQDIKRIIVRLAHSGVGILITDHNVRETLQITDRAYIIHCGHIIAQGSPQEVVRSSHVRQVYLGSQFQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83786</accession>
    <name>ACP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name type="ordered locus">TP_0808</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71277">
        <property type="entry name" value="F71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882253.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83786"/>
    <dbReference type="SMR" id="O83786"/>
    <dbReference type="STRING" id="243276.TPANIC_0808"/>
    <dbReference type="EnsemblBacteria" id="AAC65777">
        <property type="protein sequence ID" value="AAC65777"/>
        <property type="gene ID" value="TP_0808"/>
    </dbReference>
    <dbReference type="GeneID" id="57879326"/>
    <dbReference type="KEGG" id="tpa:TP_0808"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_12"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180210" description="Acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <sequence length="78" mass="8899" checksum="EF3158358484E58E" modified="1998-11-01" version="1">MDELFLRMRALVAEKLEVEEASITLDSSFRGDLGADSLDTYELVYAIEEEMGITIPDEKANEFETVRDAYEFIKSKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83798</accession>
    <name>O83798_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ordered locus">TP_0826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71276">
        <property type="entry name" value="D71276"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882270.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83798">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0826"/>
    <dbReference type="EnsemblBacteria" id="AAC65793">
        <property type="protein sequence ID" value="AAC65793"/>
        <property type="gene ID" value="TP_0826"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75996">
        <property type="protein sequence ID" value="AGN75996"/>
        <property type="gene ID" value="TPANIC_0826"/>
    </dbReference>
    <dbReference type="GeneID" id="57879343"/>
    <dbReference type="KEGG" id="tpa:TP_0826"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.813"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_1_12"/>
    <dbReference type="OMA" id="ILWQGEL"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="85"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAC65793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="273" mass="30332" checksum="0402FC9DDF223336" modified="1998-11-01" version="1">MLFLRSMVLWYAAYVRPLLDVALLSFLLYKTYEILVKTQAVQLVKGAFSILVLYALVFVLKLETLLWILNATAPGVAISITIVFQPELRKIFLKIGEKNWLRQRECAHHTHIDAVLTAADVLSKRKRGMLVVFARHHTVREVSETGTALYARLSSSLLVTIFGHDTPMHDGAVIVRDGLVVSAGSFLPLSEQHDIRKTFGTRHRAALGMAEKTDAITLVVSEETGALSLAYDSKLYYDLPHADVLAQLKQLLETTTRAGHAQGTLDHGRSTLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83819</accession>
    <name>Y847_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0847</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0847</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71273">
        <property type="entry name" value="G71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882291.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83819">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0847"/>
    <dbReference type="EnsemblBacteria" id="AAC65820">
        <property type="protein sequence ID" value="AAC65820"/>
        <property type="gene ID" value="TP_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0847"/>
    <dbReference type="eggNOG" id="ENOG502ZM78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2157263_0_0_12"/>
    <dbReference type="OMA" id="SAYGEAH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202338" description="Uncharacterized protein TP_0847">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="111" mass="12511" checksum="202F884BFDAB4CF0" modified="1998-11-01" version="1">MLNLGQVKVLEEKVAKAVHLVQMLKEENAALRAEIDGRGKRITELEQLVLXFQDDQTKIEEGILKALNHLSTFEDSAYGEALTQHAAKVLENREHAGLSEELTSRTQMEIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83820</accession>
    <name>RL20_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplT</name>
        <name type="ordered locus">TP_0848</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71273">
        <property type="entry name" value="H71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882292.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83820"/>
    <dbReference type="SMR" id="O83820"/>
    <dbReference type="IntAct" id="O83820">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0848"/>
    <dbReference type="EnsemblBacteria" id="AAC65814">
        <property type="protein sequence ID" value="AAC65814"/>
        <property type="gene ID" value="TP_0848"/>
    </dbReference>
    <dbReference type="GeneID" id="57879365"/>
    <dbReference type="KEGG" id="tpa:TP_0848"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_12"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000177253" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="122" mass="13401" checksum="7F1C75020A1DA2F0" modified="1998-11-01" version="1">MSRSLSSNGRVRRRKRILKLAKGFRGRCGTNYKAAKDAVSKALAHSYVARRDRKGSMRRLWISRINASVRTQGLSYSRFMNGLLQAGIALNRKVLSNMAIEDPGAFQTVIDASKKALGGGAC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83828</accession>
    <name>Y856_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0164 protein TP_0856</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0856</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0164 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71271">
        <property type="entry name" value="H71271"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83828"/>
    <dbReference type="IntAct" id="O83828">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0856"/>
    <dbReference type="EnsemblBacteria" id="AAC65828">
        <property type="protein sequence ID" value="AAC65828"/>
        <property type="gene ID" value="TP_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0856"/>
    <dbReference type="HOGENOM" id="CLU_060535_0_0_12"/>
    <dbReference type="OMA" id="GFRMAQG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005362">
        <property type="entry name" value="UPF0164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03687">
        <property type="entry name" value="UPF0164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000036217" description="UPF0164 protein TP_0856">
        <location>
            <begin position="29"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="325" mass="34055" checksum="F9CFDCBD253C07D2" modified="1998-11-01" version="1" precursor="true">MVHYKSVFYKSAALVCGFVLAGASVAIASSEAAAKTRSKMSEFKRRAVSSPSGGRLSVLDGSFTALANDASFFEANPAGSANMTHSELTFAHTVGFNNSHAETLSYVGQSGNWGYGASMRMFFPESGFNFSPSTGPVCTPASNPIKKLGGLGIVNFSRRFGGLSIGANLKAGFRDAQGLTHLSLGTDVGLQWVGNVAKFFSSAEPNMYVGLSATNLGFTVKLPGSPFVLCRATGEQCCKTCSGRCTGVGTCCNGEKPCCKDCDCNCPCQDEATPGSPHATDTMLRAGFAYRPLSWFLFSVGVATRVNVSNLQVDHSGSALPMRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83882</accession>
    <name>O83882_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71268">
        <property type="entry name" value="E71268"/>
    </dbReference>
    <dbReference type="IntAct" id="O83882">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0912"/>
    <dbReference type="EnsemblBacteria" id="AAC65863">
        <property type="protein sequence ID" value="AAC65863"/>
        <property type="gene ID" value="TP_0912"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76080">
        <property type="protein sequence ID" value="AGN76080"/>
        <property type="gene ID" value="TPANIC_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0912"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.895"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_12"/>
    <dbReference type="OMA" id="SKDVCLM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021812">
        <property type="entry name" value="DUF3391"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11871">
        <property type="entry name" value="DUF3391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="182"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="440" mass="49061" checksum="9BD32C5C1C72E7D1" modified="1998-11-01" version="1">MCIRRGINPCAPMPKIRRVKRYRSMSQKIDVSELQEGMCFSEPVFFDDGENLLLREGEPVSTRELTVLQDWNIPYVVTAGRVLAEGESVPSSTVEELAEFEELAAEELLDPEDDIVSTGELRTQDILKDICELLPKVCINPHYHEEYVGFIQELNMLFAKMNAHTTLPARPADMLAKRLSELVRANTLGFVSLVLSYKIEGFRFAKPAVDTAIFSIIVAQHLGFSEKDIFDLVVASLLHDIGMQHVPADILKKSGRLHFQEQQAVDAHTIYAHSYIVNTLKYPNSVGLSVLQHHEHWNGKGYPQSLSGNKITIGARILAVTDNFAAMLAPKSYRKPFSGYQAMKSLLADNARRFDPDVIKAMIQSVGIYPIGSLVLLNNSAVARVVKTTATAPLRPCLRIVIDEHDVTHPDDSGEFIDLAVNKTNYIVGEVSPWSYAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83923</accession>
    <name>O83923_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tp33 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2012" name="J. Mol. Biol." volume="416" first="678" last="696">
            <title>Structural, bioinformatic, and in vivo analyses of two Treponema pallidum lipoproteins reveal a unique TRAP transporter.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Goldberg M."/>
                <person name="Schuck P."/>
                <person name="Tomchick D.R."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="22306465"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2012.01.015"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 15-342</scope>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="J. Mol. Biol." volume="420" first="70" last="86">
            <title>Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT).</title>
            <authorList>
                <person name="Brautigam C.A."/>
                <person name="Deka R.K."/>
                <person name="Schuck P."/>
                <person name="Tomchick D.R."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="22504226"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2012.04.001"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 21-342</scope>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71258">
        <property type="entry name" value="H71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882401.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="3U65">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A/B=15-342"/>
    </dbReference>
    <dbReference type="PDB" id="4DI3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.05 A"/>
        <property type="chains" value="D/E=21-342"/>
    </dbReference>
    <dbReference type="PDB" id="4DI4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.71 A"/>
        <property type="chains" value="B=21-342"/>
    </dbReference>
    <dbReference type="PDBsum" id="3U65"/>
    <dbReference type="PDBsum" id="4DI3"/>
    <dbReference type="PDBsum" id="4DI4"/>
    <dbReference type="SMR" id="O83923"/>
    <dbReference type="IntAct" id="O83923">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0957"/>
    <dbReference type="TCDB" id="2.A.56.2.1">
        <property type="family name" value="the tripartite atp-independent periplasmic transporter (trap-t) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65913">
        <property type="protein sequence ID" value="AAC65913"/>
        <property type="gene ID" value="TP_0957"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76122">
        <property type="protein sequence ID" value="AGN76122"/>
        <property type="gene ID" value="TPANIC_0957"/>
    </dbReference>
    <dbReference type="GeneID" id="57879467"/>
    <dbReference type="KEGG" id="tpa:TP_0957"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.941"/>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036176_6_0_12"/>
    <dbReference type="OMA" id="AQMECAF"/>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3U65"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4DI3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4DI4"/>
        </source>
    </evidence>
    <sequence length="342" mass="38312" checksum="9678BF93ED6FF5A0" modified="1998-11-01" version="1">MRTYFFMSVCSVLTCFGLYAKEKVVLKIASIAPARSIWETELKKLSAEWSEITGGLVSMKFYDMSSLGGEREGIRKLKSSRPGQAAPLDGAVFSCLGLSELAPDSGIYTLSVPFLIQNEKDLERVLHELREDLDRPFRAAGFRVITWTNAGWLSFYTRAPYASLGQLKKQTIALSSLDSSVLGTCFRICGFDIKDAPNARLAPLLKAGSIDGFLSVHLFTWATGFYRYISYALDTKICPAVIGMLISDGSWARIPSRYHDAMLQAATRVRQRLANNLETLDRECSNNIQKAGVSIVHLTPQEIQEWRTEFAADVKRIQARLPGMLNMTLYEKIKHLLYSAQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83933</accession>
    <name>Y967_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0967</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0967</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TP096X family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71260">
        <property type="entry name" value="B71260"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882411.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83933"/>
    <dbReference type="STRING" id="243276.TPANIC_0967"/>
    <dbReference type="EnsemblBacteria" id="AAC65925">
        <property type="protein sequence ID" value="AAC65925"/>
        <property type="gene ID" value="TP_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0967"/>
    <dbReference type="eggNOG" id="ENOG5032M6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532003_0_0_12"/>
    <dbReference type="OMA" id="AGNGWQK"/>
    <dbReference type="OrthoDB" id="397678at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202365" description="Uncharacterized protein TP_0967">
        <location>
            <begin position="1"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="517" mass="56597" checksum="E224976333989DF6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83954</accession>
    <name>O83954_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71256">
        <property type="entry name" value="E71256"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882433.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83954">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0989"/>
    <dbReference type="EnsemblBacteria" id="AAC65945">
        <property type="protein sequence ID" value="AAC65945"/>
        <property type="gene ID" value="TP_0989"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76153">
        <property type="protein sequence ID" value="AGN76153"/>
        <property type="gene ID" value="TPANIC_0989"/>
    </dbReference>
    <dbReference type="GeneID" id="57879498"/>
    <dbReference type="KEGG" id="tpa:TP_0989"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.974"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100242_0_0_12"/>
    <dbReference type="OMA" id="WTNDEYN"/>
    <dbReference type="OrthoDB" id="1557417at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMPK1_CBM" evidence="1">
        <location>
            <begin position="209"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="290" mass="31695" checksum="3192F82591296FE9" modified="1998-11-01" version="1">MKSARRTGFPLACACISRSCARYGFRVCRAFASSPGPVVWGCVRGGALCRGGSRNSMRGCALGVMLVLSGAVGLCAAGLDPTQRRALIESISRVEAPRIQGRCVVFTASGAARHVGIAFEHEGYRPIYSFVRLSQESAQNLTERSVLFHIAPIPEGCSRLSYRLVIDGLWTTDPENSFESYDHRDGMSISYLDVPSHESYQTQHTAAGTRFVYQGAAGQTIHLAGTFNNWDPFMYSLEEVRPGHYELELPLPPGRWLYAFVKDGTSSFDTQSNARAYLADGRVANVVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83961</accession>
    <name>O83961_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71255">
        <property type="entry name" value="E71255"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882440.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0996"/>
    <dbReference type="EnsemblBacteria" id="AAC26584">
        <property type="protein sequence ID" value="AAC26584"/>
        <property type="gene ID" value="TP_0996"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76160">
        <property type="protein sequence ID" value="AGN76160"/>
        <property type="gene ID" value="TPANIC_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0996"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.981"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523638_0_0_12"/>
    <dbReference type="OMA" id="LISKTIW"/>
    <dbReference type="OrthoDB" id="365257at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC26584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="538" mass="61486" checksum="FDB4E6EAE413A05A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-08-29" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83964</accession>
    <name>FTSK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA translocase FtsK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ftsK</name>
        <name type="ordered locus">TP_0999</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Located at the septum.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71255">
        <property type="entry name" value="H71255"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882443.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83964"/>
    <dbReference type="SMR" id="O83964"/>
    <dbReference type="STRING" id="243276.TPANIC_0999"/>
    <dbReference type="EnsemblBacteria" id="AAC26587">
        <property type="protein sequence ID" value="AAC26587"/>
        <property type="gene ID" value="TP_0999"/>
    </dbReference>
    <dbReference type="GeneID" id="57879510"/>
    <dbReference type="KEGG" id="tpa:TP_0999"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_11_2_12"/>
    <dbReference type="OMA" id="IYGEKCY"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000098313" description="DNA translocase FtsK">
        <location>
            <begin position="1"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="145"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="470"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="490"/>
            <end position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="799" mass="86606" checksum="009E39B56A82DE67" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83975</accession>
    <name>PTH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">TP_1011</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71252">
        <property type="entry name" value="G71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882455.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83975"/>
    <dbReference type="SMR" id="O83975"/>
    <dbReference type="IntAct" id="O83975">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1011"/>
    <dbReference type="EnsemblBacteria" id="AAC65962">
        <property type="protein sequence ID" value="AAC65962"/>
        <property type="gene ID" value="TP_1011"/>
    </dbReference>
    <dbReference type="GeneID" id="57879522"/>
    <dbReference type="KEGG" id="tpa:TP_1011"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_2_12"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187846" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="202" mass="22178" checksum="9ABCB684733A0047" modified="1998-11-01" version="1">MGIQLIVFLGNPGAEYEETRHNAAWLLLTYLFPSIVLPWRCGCRGSIARIEGFEGSSEEVWLLKPLTYMNRSGKSVGAACAFLQTDAKQLLVVHDELELPFGVVSLKQGGGLGGHNGLRSIKEVLGTADFWRLRIGIGRPPSESVNIAQYVLSAFYPAEMAAFPKLGRATRDLLCQLVVTDQAATVTLLSAWRKKRLLSLCE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83979</accession>
    <name>NUSB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">TP_1015</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71253">
        <property type="entry name" value="C71253"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882459.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83979"/>
    <dbReference type="SMR" id="O83979"/>
    <dbReference type="STRING" id="243276.TPANIC_1015"/>
    <dbReference type="EnsemblBacteria" id="AAC65965">
        <property type="protein sequence ID" value="AAC65965"/>
        <property type="gene ID" value="TP_1015"/>
    </dbReference>
    <dbReference type="GeneID" id="57879526"/>
    <dbReference type="KEGG" id="tpa:TP_1015"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_0_12"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176601" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="141" mass="16014" checksum="EE40072F6C2A66E2" modified="1998-11-01" version="1">MSEVFPKIGRRRARILAFQALFAWDAAGITPETLTQFTWLRRNPPPSTQDLGFSRLLFLGTLEHLREIDGCVSSRLEHWDFVRLNKVDKAILRLSAYSLLFQKDIPPVVVIHEAVSIARDFGTDDSFRFVNGVLDNIAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83989</accession>
    <name>O83989_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligoendopeptidase F, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_1026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71251">
        <property type="entry name" value="E71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882470.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1026"/>
    <dbReference type="MEROPS" id="M03.010"/>
    <dbReference type="EnsemblBacteria" id="AAC65976">
        <property type="protein sequence ID" value="AAC65976"/>
        <property type="gene ID" value="TP_1026"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76190">
        <property type="protein sequence ID" value="AGN76190"/>
        <property type="gene ID" value="TPANIC_1026"/>
    </dbReference>
    <dbReference type="GeneID" id="57879538"/>
    <dbReference type="KEGG" id="tpa:TP_1026"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.1014"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030403_1_0_12"/>
    <dbReference type="OMA" id="CAFQFWK"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="312"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="589" mass="68793" checksum="FB69DAE4679D538E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="152" xmlns="http://uniprot.org/uniprot">
    <accession>O83999</accession>
    <name>O83999_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation-transporting ATPase, P-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_1036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71250">
        <property type="entry name" value="C71250"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882480.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1036"/>
    <dbReference type="EnsemblBacteria" id="AAC26590">
        <property type="protein sequence ID" value="AAC26590"/>
        <property type="gene ID" value="TP_1036"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76200">
        <property type="protein sequence ID" value="AGN76200"/>
        <property type="gene ID" value="TPANIC_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1036"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.1024"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_12"/>
    <dbReference type="OMA" id="HWMLPAW"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="763"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC26590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="792" mass="84084" checksum="80954DD709B07A95" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O84001</accession>
    <name>APT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">TP_1039</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71250">
        <property type="entry name" value="F71250"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882483.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O84001"/>
    <dbReference type="SMR" id="O84001"/>
    <dbReference type="IntAct" id="O84001">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1039"/>
    <dbReference type="EnsemblBacteria" id="AAC26593">
        <property type="protein sequence ID" value="AAC26593"/>
        <property type="gene ID" value="TP_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1039"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_12"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000149481" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="190" mass="20902" checksum="EC12F26DAEDC5D81" modified="1998-11-01" version="1">MRGIGRYHAPVDGHAALDRAIRKRIDFPKKGILYYDITGVLMNAAVFRYCLDQMVEFYRDEHVTAVAAIESRGFIFAAPFADRMGIPLILVRKAGKLPGDTYSCSYSLEYGKATVEVHKSDVVAGARVLLTDDLIATGGTLNAARTMLRAGGAEVVGFFAVVGLPFLRYHELIGDLPVRTLIEYNQETSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1988-04-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>P07643</accession>
    <name>TMPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Treponemal membrane protein A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Antigen TmpA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Membrane protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tmpA</name>
        <name type="ordered locus">TP_0768</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1985" name="J. Bacteriol." volume="162" first="1227" last="1237">
            <title>Genetic characterization and partial sequence determination of a Treponema pallidum operon expressing two immunogenic membrane proteins in Escherichia coli.</title>
            <authorList>
                <person name="Hansen E.B."/>
                <person name="Pedersen P.E."/>
                <person name="Schouls L.M."/>
                <person name="Severin E."/>
                <person name="van Embden J.D.A."/>
            </authorList>
            <dbReference type="PubMed" id="3922944"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="Infect. Immun." volume="59" first="3536" last="3546">
            <title>Characterization of the 35-kilodalton Treponema pallidum subsp. pallidum recombinant lipoprotein TmpC and antibody response to lipidated and nonlipidated T. pallidum antigens.</title>
            <authorList>
                <person name="Schouls L.M."/>
                <person name="van der Heide H.G.J."/>
                <person name="van Embden J.D.A."/>
            </authorList>
            <dbReference type="PubMed" id="1894360"/>
        </citation>
        <scope>DIACYLGLYCEROL AT CYS-22</scope>
        <scope>PALMITOYLATION AT CYS-22</scope>
        <scope>MUTAGENESIS OF CYS-22</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">To T.phagedenis TmpA.</text>
    </comment>
    <dbReference type="EMBL" id="M10931">
        <property type="protein sequence ID" value="AAA27481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A24587">
        <property type="entry name" value="A24587"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882213.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P07643"/>
    <dbReference type="SMR" id="P07643"/>
    <dbReference type="IntAct" id="P07643">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0768"/>
    <dbReference type="EnsemblBacteria" id="AAC65736">
        <property type="protein sequence ID" value="AAC65736"/>
        <property type="gene ID" value="TP_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0768"/>
    <dbReference type="eggNOG" id="ENOG5031CFT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871359_0_0_12"/>
    <dbReference type="OMA" id="FWEASEA"/>
    <dbReference type="OrthoDB" id="1091615at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018197" description="Treponemal membrane protein A">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of lipid incorporation and cleavage at alternative processing site." evidence="2">
        <original>C</original>
        <variation>S</variation>
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1894360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="345" mass="37285" checksum="92CA2331761BEC94" modified="1988-04-01" version="1" precursor="true">MNAHTLVYSGVALACAAMLGSCASGAKEEAEKKAAEQRALLVESAHADRRLMEARIGAQESGADTQHPELFSQIQDVERQSTDAKIEGDLKKAAGVASEAADKYEILRNRVEVADLQSKIQTHQLAQYDGDSANAAEESWKKALELYETDSAQCLQSTVEALESYRKVAHEGFGRLLPDMKARAGAAKTDVGGLKVAVELRPQLEEADSQYQEAREAEEVNARAKAFSGYHRALEIYTELGKVVRLKKTEAEKALQSAKTKQKASSDLARSADKSAPLPENAQGFSKEPIEVEPLPNDRLNTTQADESAPIPISDTSSPSRVQSRGVEDGGRSPKSSMNEEGASR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-11-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>P18193</accession>
    <name>FLAA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar filament outer layer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Sheath protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">flaA</name>
        <name type="ordered locus">TP_0249</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Infect. Immun." volume="58" first="2025" last="2034">
            <title>Expression in Escherichia coli of the 37-kilodalton endoflagellar sheath protein of Treponema pallidum by use of the polymerase chain reaction and a T7 expression system.</title>
            <authorList>
                <person name="Isaacs R.D."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="2194955"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="3403" last="3411">
            <title>Molecular cloning and DNA sequence analysis of the 37-kilodalton endoflagellar sheath protein gene of Treponema pallidum.</title>
            <authorList>
                <person name="Isaacs R.D."/>
                <person name="Hanke J.H."/>
                <person name="Guzman-Verduzco L.-M."/>
                <person name="Newport G."/>
                <person name="Agabian N."/>
                <person name="Norgard M.V."/>
                <person name="Lukehart S.A."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="2680972"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-350</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6499" last="6508">
            <title>TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability.</title>
            <authorList>
                <person name="Hazlett K.R."/>
                <person name="Cox D.L."/>
                <person name="Decaffmeyer M."/>
                <person name="Bennett M.P."/>
                <person name="Desrosiers D.C."/>
                <person name="La Vake C.J."/>
                <person name="La Vake M.E."/>
                <person name="Bourell K.W."/>
                <person name="Robinson E.J."/>
                <person name="Brasseur R."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="16159783"/>
            <dbReference type="DOI" id="10.1128/JB.187.18.6499-6508.2005"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2015" name="J. Bacteriol." volume="197" first="1906" last="1920">
            <title>A homology model reveals novel structural features and an immunodominant surface loop/opsonic target in the Treponema pallidum BamA ortholog TP_0326.</title>
            <authorList>
                <person name="Luthra A."/>
                <person name="Anand A."/>
                <person name="Hawley K.L."/>
                <person name="LeDoyt M."/>
                <person name="La Vake C.J."/>
                <person name="Caimano M.J."/>
                <person name="Cruz A.R."/>
                <person name="Salazar J.C."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="25825429"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>Nichols-Farmington</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Component of the outer layer of the flagella.</text>
    </comment>
    <comment type="subunit">
        <text>The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Periplasmic flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 3">Periplasm</location>
        </subcellularLocation>
        <text evidence="2">Antibody labeling only occurs after mild detergent solubilization (PubMed:25825429).</text>
    </comment>
    <dbReference type="EMBL" id="M63142">
        <property type="protein sequence ID" value="AAA27477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M26525">
        <property type="protein sequence ID" value="AAA27476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71348">
        <property type="entry name" value="D71348"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881697.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P18193"/>
    <dbReference type="IntAct" id="P18193">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0249"/>
    <dbReference type="EnsemblBacteria" id="AAC65235">
        <property type="protein sequence ID" value="AAC65235"/>
        <property type="gene ID" value="TP_0249"/>
    </dbReference>
    <dbReference type="GeneID" id="57878791"/>
    <dbReference type="KEGG" id="tpa:TP_0249"/>
    <dbReference type="eggNOG" id="ENOG50329D7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821088_0_0_12"/>
    <dbReference type="OMA" id="EDMSGME"/>
    <dbReference type="OrthoDB" id="735776at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006714">
        <property type="entry name" value="FlaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016369">
        <property type="entry name" value="FlaA_Spirochaetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04620">
        <property type="entry name" value="FlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002892">
        <property type="entry name" value="Flagellin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000009354" description="Flagellar filament outer layer protein">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="25825429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="16159783"/>
        </source>
    </evidence>
    <sequence length="350" mass="38857" checksum="2BC7C7EFA0CDB4C7" modified="1996-10-01" version="2" precursor="true">MKKAVVLSAVALLSGVCAVADESVLIDFAKLNADIMADKSGGMTHNRRTVLDYASLADTSYTDEQKALMRSSLAVAQWEVVLNSSARNPVAHAASRVIEAPVSEGAKSFAGERVLGVRVLFPTWDSNANAMIKPAFVIPAYEVMAQVDDQGNVQAPTEEEKASGKGRFEDGYGVVKNVGVLKSIAVNTYGMNYPHGLYVMMRDQDGEVHRYFMGYLLFDSWKELVWNNPSYISDVRSREVRLYPVYPASTPHVVFEGFMVTRDAAHAGGDYVGYFKDVKIIYDKAVLSTVRDFADEDLWGIQARREAERKRVEVARFGQQQVLRYIEQEKLATEVGFTPSGGAQRQEEQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-02-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>P19649</accession>
    <name>TMPB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Treponemal membrane protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Antigen TmpB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tmpB</name>
        <name type="ordered locus">TP_0769</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Infect. Immun." volume="59" first="3685" last="3693">
            <title>Treponema phagedenis encodes and expresses homologs of the Treponema pallidum TmpA and TmpB proteins.</title>
            <authorList>
                <person name="Yelton D.B."/>
                <person name="Limberger R.J."/>
                <person name="Curci K."/>
                <person name="Malinosky-Rummell F."/>
                <person name="Sliviensky L."/>
                <person name="Schouls L.M."/>
                <person name="van Embden J.D.A."/>
                <person name="Charon N.W."/>
            </authorList>
            <dbReference type="PubMed" id="1894368"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1985" name="J. Bacteriol." volume="162" first="1227" last="1237">
            <title>Genetic characterization and partial sequence determination of a Treponema pallidum operon expressing two immunogenic membrane proteins in Escherichia coli.</title>
            <authorList>
                <person name="Hansen E.B."/>
                <person name="Pedersen P.E."/>
                <person name="Schouls L.M."/>
                <person name="Severin E."/>
                <person name="van Embden J.D.A."/>
            </authorList>
            <dbReference type="PubMed" id="3922944"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25</scope>
    </reference>
    <comment type="function">
        <text>Tmp may serve as a porin or transport protein for large molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell outer membrane</location>
            <topology>Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">To T.phagedenis TmpB.</text>
    </comment>
    <dbReference type="EMBL" id="M58562">
        <property type="protein sequence ID" value="AAA27479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="M10931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71283">
        <property type="entry name" value="F71283"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882214.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P19649"/>
    <dbReference type="STRING" id="243276.TPANIC_0769"/>
    <dbReference type="PRIDE" id="P19649"/>
    <dbReference type="EnsemblBacteria" id="AAC65737">
        <property type="protein sequence ID" value="AAC65737"/>
        <property type="gene ID" value="TP_0769"/>
    </dbReference>
    <dbReference type="GeneID" id="57879606"/>
    <dbReference type="KEGG" id="tpa:TP_0769"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042249_0_0_12"/>
    <dbReference type="OMA" id="YTVRPWA"/>
    <dbReference type="OrthoDB" id="1649981at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000022559" description="Treponemal membrane protein B">
        <location>
            <begin position="25"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="EAARKAAE">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARKLEEQRIAAQKAQEERKRAEE">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="EAARKAAE">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ARKLEEQRIAAQKAQEERKRAEE">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="EAARKAAE">
        <location>
            <begin position="221"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="EAARKAEE">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="325" mass="36961" checksum="31B479986D4A3C71" modified="1993-04-01" version="2" precursor="true">MKTRNFSLVSALYVLLGVPLFVSAASYDDNEFSRKSRAYSELAEKTYDAGEYDVSAEYARLAEDFAQKSSVYIKETMARTTAEDAMNAARTRHAWAKNERIDRAYPTEYLLASEAIKTGGLAFDSKQYDVALTWARKALDALKNVKPESQLLAKAAKEEAARKAAEARKLEEQRIAAQKAQEERKRAEEEAARKAAEARKLEEQRIAAQKAQEERKRAEEEAARKAAEEAARKAEELEKGRVLPAQYKVTTWSIDRECFWNIAKNPAVYGNPFLWKKLYEANKDKIPQSKNPNWVEPETVLVIPSLKGEEREGLYEPNVKYRPLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-08-01" modified="2022-05-25" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>P21992</accession>
    <accession>O83840</accession>
    <name>FLAB3_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin FlaB3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Flagellar filament 31 kDa core protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">flaB3</name>
        <name type="ordered locus">TP_0870</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Infect. Immun." volume="58" first="1697" last="1704">
            <title>Cloning, sequencing, and expression of two class B endoflagellar genes of Treponema pallidum subsp. pallidum encoding the 34.5- and 31.0-kilodalton proteins.</title>
            <authorList>
                <person name="Champion C.I."/>
                <person name="Miller J.N."/>
                <person name="Lovett M.A."/>
                <person name="Blanco D.R."/>
            </authorList>
            <dbReference type="PubMed" id="2187805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1988" name="J. Bacteriol." volume="170" first="4072" last="4082">
            <title>Antigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenis.</title>
            <authorList>
                <person name="Norris S.J."/>
                <person name="Charon N.W."/>
                <person name="Cook R.G."/>
                <person name="Fuentes M.D."/>
                <person name="Limberger R.J."/>
            </authorList>
            <dbReference type="PubMed" id="3045083"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 1-30</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="7700" last="7706">
            <title>Novel conserved assembly factor of the bacterial flagellum.</title>
            <authorList>
                <person name="Titz B."/>
                <person name="Rajagopala S.V."/>
                <person name="Ester C."/>
                <person name="Haeuser R."/>
                <person name="Uetz P."/>
            </authorList>
            <dbReference type="PubMed" id="16936039"/>
            <dbReference type="DOI" id="10.1128/JB.00820-06"/>
        </citation>
        <scope>INTERACTION WITH FLIW</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Component of the core of the flagella.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides. Interacts with FliW; a synthetic peptide of FlaB1 (residues 229-247) partially blocks binding of this protein to FliW (PubMed:16936039).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Periplasmic flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="X63965">
        <property type="protein sequence ID" value="CAA45382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A41489">
        <property type="entry name" value="A41489"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882313.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P21992"/>
    <dbReference type="SMR" id="P21992"/>
    <dbReference type="IntAct" id="P21992">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0870"/>
    <dbReference type="EnsemblBacteria" id="AAC65835">
        <property type="protein sequence ID" value="AAC65835"/>
        <property type="gene ID" value="TP_0870"/>
    </dbReference>
    <dbReference type="GeneID" id="57879385"/>
    <dbReference type="KEGG" id="tpa:TP_0870"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_2_0_12"/>
    <dbReference type="OMA" id="ENEKRMN"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182636" description="Flagellin FlaB3">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA45382." evidence="3" ref="1">
        <original>QQ</original>
        <variation>HE</variation>
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16936039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="2187805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="285" mass="31055" checksum="CB75EBCFDE8B1244" modified="1998-12-15" version="3">MIINHNMSAMFAQRQGGINGLAIAKNIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLNQAGQNIQNGISFIQATEGYLAETTEIVQRLRELAIQAANGIYSAEDRMQIQVEVSQLVDEVDRIASQAQFNGMNLLTGRFSRESALGPMQLHVGANMDQNEKIFINTMTASALGFFSDEGTDGSRSISIATVDGANKVIGTLDSALKEINKQRADLGAYQNRFETAYQGIAIAAENLQAAESRIRDADLAQQMVDYTKNQILEQSTMAMLAQANTQPQAVLRLMQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>P74931</accession>
    <name>FLIQ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliQ</name>
        <name type="ordered locus">TP_0717</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Gene" volume="166" first="57" last="64">
            <title>Identification and sequences of the Treponema pallidum fliM', fliY, fliP, fliQ, fliR and flhB' genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="8529894"/>
            <dbReference type="DOI" id="10.1016/0378-1119(95)00583-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4508">
        <property type="entry name" value="JC4508"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74931"/>
    <dbReference type="SMR" id="P74931"/>
    <dbReference type="IntAct" id="P74931">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0717"/>
    <dbReference type="EnsemblBacteria" id="AAC65683">
        <property type="protein sequence ID" value="AAC65683"/>
        <property type="gene ID" value="TP_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0717"/>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164516_2_0_12"/>
    <dbReference type="OMA" id="TMPWMLN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000129102" description="Flagellar biosynthetic protein FliQ">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="94" mass="10186" checksum="E58A188206B3917F" modified="1997-02-01" version="1">MMTQGAVLGLIREGVFQVVLLVAPVLCTALVVGLIVAIFQAVTSIQEQTLTFVPKMLTILGMIALLGGWMLTMLQNYTVRLFDIIPQLVRSGPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>P96122</accession>
    <accession>O83200</accession>
    <name>MTNN_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase</fullName>
            <shortName evidence="1">MTA/SAH nucleosidase</shortName>
            <shortName evidence="1">MTAN</shortName>
            <ecNumber evidence="1">3.2.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-deoxyadenosine nucleosidase</fullName>
            <shortName evidence="1">DOA nucleosidase</shortName>
            <shortName evidence="1">dAdo nucleosidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine nucleosidase</fullName>
            <shortName evidence="1">MTA nucleosidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylhomocysteine nucleosidase</fullName>
            <shortName evidence="1">AdoHcy nucleosidase</shortName>
            <shortName evidence="1">SAH nucleosidase</shortName>
            <shortName evidence="1">SRH nucleosidase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mtnN</name>
        <name type="synonym">mtn</name>
        <name type="ordered locus">TP_0170</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="EC" id="3.2.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine</text>
            <dbReference type="Rhea" id="RHEA:13617"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:78440"/>
            <dbReference type="EC" id="3.2.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine</text>
            <dbReference type="Rhea" id="RHEA:29859"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:149540"/>
            <dbReference type="EC" id="3.2.2.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29860"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="1"/>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71357">
        <property type="entry name" value="G71357"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881617.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96122"/>
    <dbReference type="SMR" id="P96122"/>
    <dbReference type="IntAct" id="P96122">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0170"/>
    <dbReference type="EnsemblBacteria" id="AAC65159">
        <property type="protein sequence ID" value="AAC65159"/>
        <property type="gene ID" value="TP_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="57878712"/>
    <dbReference type="KEGG" id="tpa:TP_0170"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_2_0_12"/>
    <dbReference type="OMA" id="DQFVHSK"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000164451" description="5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC45731." evidence="2" ref="1">
        <original>ALLTLRVLERLSALRTSVVASLFPMVVV</original>
        <variation>SPFDVACS</variation>
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AF12"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="269" mass="28666" checksum="20F16DEADFA2E2E6" modified="2000-05-30" version="2">MTVGVFAALGEEVARVRECLGGVGTERAGLTFYVVSVGALQVVYVCGGVGKVNAALCTQLLISEFGARVLINTGIAGALDERLCVFDVLVSVDAVQHDVDVTAFGYQKGRIPRMDSVEWTANTALRYLVREAFDLCTRDPEWTEGACALSGSGDPPSRVSRLVEGRVASGDLFVSDAQTRARIIREFGAHGVEMEGAAFAHVASVNGVPFVIIRCISDGAGAEQDVSMSYKEFSTRAARRSALLTLRVLERLSALRTSVVASLFPMVVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1994-10-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q08255</accession>
    <name>MGLB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Glucose/galactose-binding lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mglB</name>
        <name type="synonym">tpp38</name>
        <name type="ordered locus">TP_0684</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1994" name="Infect. Immun." volume="62" first="1381" last="1391">
            <title>Similarity between the 38-kilodalton lipoprotein of Treponema pallidum and the glucose/galactose-binding (MglB) protein of Escherichia coli.</title>
            <authorList>
                <person name="Becker P.S."/>
                <person name="Akins D.R."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="8132345"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Gene" volume="177" first="115" last="121">
            <title>A mgl-like operon in Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Porcella S.F."/>
                <person name="Popova T.G."/>
                <person name="Hagman K.E."/>
                <person name="Penn C.W."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="8921855"/>
            <dbReference type="DOI" id="10.1016/0378-1119(96)00286-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>May be involved in the transport of sugars. May have a role in chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="L20301">
        <property type="protein sequence ID" value="AAA27473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U48416">
        <property type="protein sequence ID" value="AAC44584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC5171">
        <property type="entry name" value="JC5171"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882129.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="5JX2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A=36-403"/>
    </dbReference>
    <dbReference type="PDB" id="6BGC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.08 A"/>
        <property type="chains" value="A/B=36-403"/>
    </dbReference>
    <dbReference type="PDB" id="6BGD">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.47 A"/>
        <property type="chains" value="A=36-403"/>
    </dbReference>
    <dbReference type="PDBsum" id="5JX2"/>
    <dbReference type="PDBsum" id="6BGC"/>
    <dbReference type="PDBsum" id="6BGD"/>
    <dbReference type="AlphaFoldDB" id="Q08255"/>
    <dbReference type="SMR" id="Q08255"/>
    <dbReference type="IntAct" id="Q08255">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0684"/>
    <dbReference type="EnsemblBacteria" id="AAC65647">
        <property type="protein sequence ID" value="AAC65647"/>
        <property type="gene ID" value="TP_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0684"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057130_0_0_12"/>
    <dbReference type="OMA" id="HNDSKAR"/>
    <dbReference type="OrthoDB" id="351138at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040740">
        <property type="entry name" value="MglB-2_Peripla_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18610">
        <property type="entry name" value="Peripla_BP_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000031743" description="Glucose/galactose-binding lipoprotein">
        <location>
            <begin position="26"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="2">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="2">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="192"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="223"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="288"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="325"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="337"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="356"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="364"/>
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        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="368"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="378"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="382"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="394"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="399"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="6BGD"/>
        </source>
    </evidence>
    <sequence length="403" mass="43052" checksum="2E05AF844EB8C5FD" modified="1994-10-01" version="1" precursor="true">MKENSCTACSRRLALFVGAAVLVVGCSSKTDVTLNRDKPLVFFNRQPSDPLTGKVDMAAMNWNDKTYYVGFDAKFGGSIQGKMILDFLASSESSVDRNGDGIIGYVLCIGDVGHNDSKVRTEGIRRALGTWTGSSDPGQAKEGQAVVGGKSYKVVELEGKAMTGTDGSTWNTNSATESMGSWVAKFADKIDLVISNNDGMAMGCLQASNYPRGLPIFGYDANADAVESVGKGELTGTVSQNVDAQAVAVLQIIRNLLDGSSGEDVVANGISRPDAHGNKISAPVQYWEDVKAIMADNSEVTSANWKEYTRGARDAGVRQVSAPTKKVLLTVHNASNDFLASAYLPALKHYAPLLNVDLTVVQGDGQNELSCLDKFTNLDMFDAFAVNMVKTNSGADYTDKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q56345</accession>
    <name>Q56345_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="A71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881491.1">
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    </dbReference>
    <dbReference type="IntAct" id="Q56345">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0042"/>
    <dbReference type="EnsemblBacteria" id="AAC65036">
        <property type="protein sequence ID" value="AAC65036"/>
        <property type="gene ID" value="TP_0042"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75262">
        <property type="protein sequence ID" value="AGN75262"/>
        <property type="gene ID" value="TPANIC_0042"/>
    </dbReference>
    <dbReference type="GeneID" id="57878583"/>
    <dbReference type="KEGG" id="tpa:TP_0042"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.38"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767138_0_0_12"/>
    <dbReference type="OMA" id="YPRIARF"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="260"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="310" mass="33200" checksum="9176754201345FF6" modified="1999-05-01" version="2">MSQEIGIKLADGSFFPLFTAEGAQRTTLELVTANDQQSRALLSFFKRVSPGDGEASVTSAELEPMGALSIDTLSVAAAGGATIRLEVECDGSRCRARATDVGSGAFQETSFSVLERSSGDATPDEQPAAQIEHVSSFPEDEGGDGSTLTRRRRILLAVCAFLILLGGVLVGWVLYMHGASRPAVVPSQKVELPRSSAHVAARELERTAVEARVVDLPSETALPETHKEKDVPPASPGAETATSAAAEPVEESGSGSVKVVRYTVKRGDTLWDLARSYYKTPWRYMRIAEFNRLKNPDHIVAGTSIEIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>F7IVV4</accession>
    <name>F7IVV4_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SpoIIIJ-associated protein (Jag)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71261">
        <property type="entry name" value="B71261"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882391.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0948"/>
    <dbReference type="EnsemblBacteria" id="AAC65905">
        <property type="protein sequence ID" value="AAC65905"/>
        <property type="gene ID" value="TP_0948"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76112">
        <property type="protein sequence ID" value="AGN76112"/>
        <property type="gene ID" value="TPANIC_0948"/>
    </dbReference>
    <dbReference type="GeneID" id="57879458"/>
    <dbReference type="KEGG" id="tpa:TP_0948"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.931"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_0_0_12"/>
    <dbReference type="OMA" id="RRVQKWP"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="231" mass="25478" checksum="882228D1838FFC62" modified="2011-07-27" version="1">MVYEFEGKTEQDAIARAAAELGLGVDQFDVEILEIQKSSLFKKGFARIRVHVAAVTASPGHAAHAQYDPVSVLSEQQFADLGAQLRAFLSHVFHAMGYAVTIDAFVRESDRVVVRLHSSHSAILIGKKGKNLDALQLLANVFFTKIGAKGVKVVLDCENYRIRREEMLIRMAYATADQVSASKRSVLLEPMNPYERRLIHTTLHGISGVETRSEGEGLYKQVRVCHTGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW50</accession>
    <name>F7IW50_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cation-activated repressor protein (TroR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71357">
        <property type="entry name" value="D71357"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881614.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0167"/>
    <dbReference type="EnsemblBacteria" id="AAC65157">
        <property type="protein sequence ID" value="AAC65157"/>
        <property type="gene ID" value="TP_0167"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75385">
        <property type="protein sequence ID" value="AGN75385"/>
        <property type="gene ID" value="TPANIC_0167"/>
    </dbReference>
    <dbReference type="GeneID" id="57878709"/>
    <dbReference type="KEGG" id="tpa:TP_0167"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.174"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_4_1_12"/>
    <dbReference type="OMA" id="EHVEMYL"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17122" checksum="774595935DC086D3" modified="2011-07-27" version="1">MSLVSDIAAENYLKTVVKALARSRRERVGTGELSRLLHVTPGTISTMVKRLEKGGYVQRTHRLGCTLTRKGAVFGSAVLRKHRLLESFLSQVLCLEAGVVHKEAEMLEHACSDELIDVIDRYLQYPTRDPHGQPIPRKDTLLDLYVEDDVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7IWE8</accession>
    <name>F7IWE8_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4506">
        <property type="entry name" value="JC4506"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882164.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0719"/>
    <dbReference type="EnsemblBacteria" id="AAC65685">
        <property type="protein sequence ID" value="AAC65685"/>
        <property type="gene ID" value="TP_0719"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75894">
        <property type="protein sequence ID" value="AGN75894"/>
        <property type="gene ID" value="TPANIC_0719"/>
    </dbReference>
    <dbReference type="GeneID" id="57879244"/>
    <dbReference type="KEGG" id="tpa:TP_0719"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.709"/>
    <dbReference type="HOGENOM" id="CLU_1133199_0_0_12"/>
    <dbReference type="OMA" id="APRAMTF"/>
    <dbReference type="OrthoDB" id="1361130at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="262" mass="28809" checksum="9E047D8EF81602CA" modified="2011-07-27" version="1">MKTLGCVLRKFSRRENVLRTFNCSLRIVPRCATLFLSVHVFLHVSFELWAQQQGVDVSAVSEAVSATSAQKEQPAPESARDTREDAFPLTPAEQAFRFDAAPVARDPSPSVFSLLLRFSLVLCVVCAAVYGFLRLIRRSAFLSSAHDPFLKRLACLPIAPGRAVYVVGLAERAFVLAASDTCISLIAEVKDKELIDTMNIVADEQGTDARADFSQMLARLLPARVTGKGKPLVEADFLADTRKKLRRIPRNDSEESAAQDAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O07884</accession>
    <name>FLGE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">flgE</name>
        <name type="ordered locus">TP_0727</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="4628" last="4634">
            <title>Organization, transcription, and expression of the 5' region of the fla operon of Treponema phagedenis and Treponema pallidum.</title>
            <authorList>
                <person name="Limberger R.J."/>
                <person name="Slivienski L.L."/>
                <person name="El-Afandi M.C."/>
                <person name="Dantuono L.A."/>
            </authorList>
            <dbReference type="PubMed" id="8755894"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="U28219">
        <property type="protein sequence ID" value="AAB61251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71292">
        <property type="entry name" value="C71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882172.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O07884"/>
    <dbReference type="SMR" id="O07884"/>
    <dbReference type="IntAct" id="O07884">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0727"/>
    <dbReference type="EnsemblBacteria" id="AAC65692">
        <property type="protein sequence ID" value="AAC65692"/>
        <property type="gene ID" value="TP_0727"/>
    </dbReference>
    <dbReference type="GeneID" id="57879251"/>
    <dbReference type="KEGG" id="tpa:TP_0727"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_2_4_12"/>
    <dbReference type="OMA" id="GLQNHQT"/>
    <dbReference type="OrthoDB" id="704242at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180832" description="Flagellar hook protein FlgE">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="463" mass="49179" checksum="947C4C413B36E7A8" modified="1997-07-01" version="1">MMRSLFSGVSGMQNHQTRMDVIGNNVANVNTTGFKRGRVNFQDLISQQLSAAARPNEEVGGVNPKEVGLGVLIASIDTVHTQGALQTTGINTDVSIQGSGFFVLKSGEKTFFTRAGAFGVDNAGTLVNPANGMRVQGWMAQDVAGERLINSSAQTQDLVIPIGQKIDAQQTSTVHYACNLDKRLPELAADANEADVRKSTWTTDFQVYDSFGQQHTLQINFSRVPGTNNQWQATVAVDPGTEVDTQTRVGVGTSDGAANTFIVNFDNFGHLASVTDTAGNVTGPTGQVLLEASYDVVGANPDDAGQVTRHAFTLNLGEIGTARNTITQFAERSTTKAYRQDGYAMGYLENFKIDQSGVITGVYSNGVSQDIGQLALAGFANQGGLEKAGENTYVQSNNSGIANISTSGVMGKGKLIAGTLEMSNVDLTDQFTDMIITQKGFQAGAKTIQTSDTMLDTVLSLKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-12-09" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O67998</accession>
    <accession>F7IW75</accession>
    <accession>Q7DFP5</accession>
    <name>TP453_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Outer membrane protein TP0453</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">30kLP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0453</name>
        <name type="ORF">TPANIC_0453</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Robinson E.J."/>
                <person name="Shevchenko O.V."/>
                <person name="Radolf J.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols-Farmington</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Clin. Microbiol." volume="41" first="3668" last="3674">
            <title>Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum.</title>
            <authorList>
                <person name="Van Voorhis W.C."/>
                <person name="Barrett L.K."/>
                <person name="Lukehart S.A."/>
                <person name="Schmidt B."/>
                <person name="Schriefer M."/>
                <person name="Cameron C.E."/>
            </authorList>
            <dbReference type="PubMed" id="12904373"/>
            <dbReference type="DOI" id="10.1128/JCM.41.8.3668-3674.2003"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6499" last="6508">
            <title>TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability.</title>
            <authorList>
                <person name="Hazlett K.R."/>
                <person name="Cox D.L."/>
                <person name="Decaffmeyer M."/>
                <person name="Bennett M.P."/>
                <person name="Desrosiers D.C."/>
                <person name="La Vake C.J."/>
                <person name="La Vake M.E."/>
                <person name="Bourell K.W."/>
                <person name="Robinson E.J."/>
                <person name="Brasseur R."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="16159783"/>
            <dbReference type="DOI" id="10.1128/JB.187.18.6499-6508.2005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>PALMITOYLATION</scope>
        <scope>MUTAGENESIS OF ILE-277</scope>
        <scope>EXPRESSION IN E.COLI</scope>
        <source>
            <strain>Nichols-Farmington</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2013" name="J. Clin. Microbiol." volume="51" first="105" last="111">
            <title>New proteins for a new perspective on syphilis diagnosis.</title>
            <authorList>
                <person name="Smith B.C."/>
                <person name="Simpson Y."/>
                <person name="Morshed M.G."/>
                <person name="Cowen L.L."/>
                <person name="Hof R."/>
                <person name="Wetherell C."/>
                <person name="Cameron C.E."/>
            </authorList>
            <dbReference type="PubMed" id="23100335"/>
            <dbReference type="DOI" id="10.1128/JCM.01390-12"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2011" name="J. Biol. Chem." volume="286" first="41656" last="41668">
            <title>The transition from closed to open conformation of Treponema pallidum outer membrane-associated lipoprotein TP0453 involves membrane sensing and integration by two amphipathic helices.</title>
            <authorList>
                <person name="Luthra A."/>
                <person name="Zhu G."/>
                <person name="Desrosiers D.C."/>
                <person name="Eggers C.H."/>
                <person name="Mulay V."/>
                <person name="Anand A."/>
                <person name="McArthur F.A."/>
                <person name="Romano F.B."/>
                <person name="Caimano M.J."/>
                <person name="Heuck A.P."/>
                <person name="Malkowski M.G."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="21965687"/>
            <dbReference type="DOI" id="10.1074/jbc.M111.305284"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 27-287</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DOMAIN</scope>
        <scope>MUTAGENESIS OF ILE-62; LEU-162; LEU-201; VAL-249 AND ILE-277</scope>
        <source>
            <strain>Nichols-Farmington</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Might be involved in ligand transport, alters membrane permeability at acidic pH (4.0 to 5.5) (PubMed:21965687). Incubation of the non-lipidated form with lipid vesicles increases their permeability (PubMed:16159783).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">A mix of monomer and dimers; may integrate into the membrane as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 9">Cell outer membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <orientation evidence="8 9">Periplasmic side</orientation>
        </subcellularLocation>
        <text evidence="3 9">An amphitropic protein able to integrate into the inner leaflet of the outer membrane, probably via amphipathic helices 7 and 8 (PubMed:21965687). It has no surface-exposed domains (PubMed:16159783).</text>
    </comment>
    <comment type="domain">
        <text evidence="3 4">Forms a U-shaped beta-half-barrel with a large hydrophobic cavity (3549 Angstroms(3)). The cavity is opened when amphipathic helices 2, 3 and 9 move away from helices 7 and 8 (PubMed:21965687). Has 5 potential amphipathic helices (P1 to P5, residues 56 to 63, 155 to 162, 194 to 202, 240 to 250, and 270 to 279 respectively); P2, P3 and P5 form helices in the presence of lipid vesicles (PubMed:16159783).</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Palmitoylated upon expression of a fusion protein with first 46 residues fused to PhoA in E.coli.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="2 5">Recognized by sera from 43/43 syphilis patients, it shows promise as a diagnostic antigen (PubMed:12904373). In diagnostic tests for syphilis this protein exhibits a sensitivity of 98% and a specificity of 100%. A fusion with TP0453 (residues 32-287 of TP0453 fused N-terminally to residues 38-450 of TP0326) exhibits a sensitivity of 98% and a specificity of 99%, and both proteins exhibit superior accuracy in classifying analytical false-positive samples than a commericially available test, making them candiates for diagnosis (PubMed:23100335).</text>
    </comment>
    <dbReference type="EMBL" id="AF007220">
        <property type="protein sequence ID" value="AAC18996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71322">
        <property type="entry name" value="F71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881902.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="3K8G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=27-287"/>
    </dbReference>
    <dbReference type="PDB" id="3K8H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.39 A"/>
        <property type="chains" value="A/B=27-287"/>
    </dbReference>
    <dbReference type="PDB" id="3K8I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=27-287"/>
    </dbReference>
    <dbReference type="PDB" id="3K8J">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A=27-287"/>
    </dbReference>
    <dbReference type="PDBsum" id="3K8G"/>
    <dbReference type="PDBsum" id="3K8H"/>
    <dbReference type="PDBsum" id="3K8I"/>
    <dbReference type="PDBsum" id="3K8J"/>
    <dbReference type="AlphaFoldDB" id="O67998"/>
    <dbReference type="SMR" id="O67998"/>
    <dbReference type="IntAct" id="O67998">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0453"/>
    <dbReference type="TCDB" id="1.B.45.1.1">
        <property type="family name" value="the treponema porin (t-por) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65443">
        <property type="protein sequence ID" value="AAC65443"/>
        <property type="gene ID" value="TP_0453"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75647">
        <property type="protein sequence ID" value="AGN75647"/>
        <property type="gene ID" value="TPANIC_0453"/>
    </dbReference>
    <dbReference type="GeneID" id="57878976"/>
    <dbReference type="KEGG" id="tpa:TP_0453"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0453"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.452"/>
    <dbReference type="eggNOG" id="ENOG50302A1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979835_0_0_12"/>
    <dbReference type="OMA" id="EAMFSER"/>
    <dbReference type="OrthoDB" id="1462388at2"/>
    <dbReference type="EvolutionaryTrace" id="O67998"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000434873" description="Outer membrane protein TP0453">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 2" evidence="9">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 3" evidence="9">
        <location>
            <begin position="69"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 4" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 5" evidence="9">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 6" evidence="9">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 7" evidence="9">
        <location>
            <begin position="194"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 8" evidence="9">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic helix 9" evidence="9">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No change in detergent partitioning, vesicle associated." evidence="4">
        <original>I</original>
        <variation>E</variation>
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No change in detergent partitioning, vesicle associated." evidence="4">
        <original>L</original>
        <variation>E</variation>
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Partitions into detergent and aqueous phase, decreased vesicle association." evidence="4">
        <original>L</original>
        <variation>E</variation>
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No longer partitions into detergent, no vesicle association, decreased dimer formation." evidence="4">
        <original>V</original>
        <variation>E</variation>
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="No change in detergent partitioning, vesicle associated, decreased dimer formation. Amphipathic peptide (residues 270 to 280) no longer forms alpha helices in the presence of lipid vesicles." evidence="3 4">
        <original>I</original>
        <variation>E</variation>
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="helix" evidence="12">
        <location>
            <begin position="30"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="70"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="79"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="155"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="224"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="270"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12904373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16159783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="21965687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23100335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="16159783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source ref="1"/>
    </evidence>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="16159783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="21965687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC18996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="3K8G"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="3K8I"/>
        </source>
    </evidence>
    <sequence length="287" mass="32000" checksum="692712D8891CC03F" modified="1998-08-01" version="1" precursor="true">MIRRRYRGCTQGAWIVSVGMLFASCTSGAWKASVDPLGVVGSGADVYLYFPVAGNENLISRIIENHESKADIKKIVDRTTAVYGAFFARSKEFRLFGSGSYPYAFTNLIFSRSDGWASTKTEHGITYYESEHTDVSIPAPHFSCVIFGSSKRERMSKMLSRLVNPDRPQLPPRFEKECTSEGTSQTVALYIKNGGHFITKLLNFPQLNLPLGAMELYLTARRNEYLYTLSLQLGNAKINFPIQFLISRVLNAHIHVEGDRLIIEDGTISAERLASVISSLYSKKGSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83052</accession>
    <name>Y007_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0007</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0007</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71378">
        <property type="entry name" value="F71378"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83052"/>
    <dbReference type="SMR" id="O83052"/>
    <dbReference type="IntAct" id="O83052">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0007"/>
    <dbReference type="EnsemblBacteria" id="AAC65003">
        <property type="protein sequence ID" value="AAC65003"/>
        <property type="gene ID" value="TP_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0007"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277152_0_0_12"/>
    <dbReference type="OMA" id="IMGYPGA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024258">
        <property type="entry name" value="DUF3798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12683">
        <property type="entry name" value="DUF3798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202171" description="Uncharacterized protein TP_0007">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <sequence length="216" mass="23835" checksum="ADFE9106B2DE5175" modified="1998-11-01" version="1">MLALAEDSTIKAIVVSQAVPGVSKAFGIIKSKRPDVLLFAGEPLEPVEMLQESADIVVSQDYLFGGYAVPWVAERMGARTLVHVSFPRHMSYPGLRVRRTVMRAACTDLGLSFAHEEAPDPVDGVSDGELEDFFHKTIVKWIKKYGKETLFYCTNDAHNRPLISALLKYGGMLIGATIFDYADALGVHYAELEDVYKIREKVEKSLVASAQRGALD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83088</accession>
    <name>O83088_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71372">
        <property type="entry name" value="C71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881498.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0049"/>
    <dbReference type="EnsemblBacteria" id="AAC65045">
        <property type="protein sequence ID" value="AAC65045"/>
        <property type="gene ID" value="TP_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0049"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.52"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_2_4_12"/>
    <dbReference type="OMA" id="QWYIHKG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="235"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37497" checksum="554505E2ACA16F24" modified="1998-11-01" version="1">MYALCAACTRSRSAPGRRRPCRTHRHVSTTLSVCGPDFLYYRSHALVRSSVRCWRVGFFFLVCPSVCHLRTFLAAVRAEVDRTQVHLALLRQEAAELIRTSKAFQTSLSQTFSQVGLSGLQSGAEKPVRSVSDTNQSNEPDDASAKDGAQKGNVGVTEQHGKNAQGVGSEPEELRRIAAYFQNSVQPVREIGKLLNSQTALFSDIPSLWPIKGGVGHISMAFGKNRHPFTGQWYVHKGIDLSTHRSGDPIVATADGHVVTVEYDSGWGNYVIIKHKHGFYTRYAHMQSYTVTRGQHIRQGQIIGYIGATGVATGPHLHYEIHIGSDVVDPGKYLNVKTAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83091</accession>
    <name>O83091_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="4">RF MTase</shortName>
            <ecNumber evidence="4">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prmC</name>
        <name evidence="6" type="ordered locus">TP_0052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="4"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71372">
        <property type="entry name" value="F71372"/>
    </dbReference>
    <dbReference type="IntAct" id="O83091">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0052"/>
    <dbReference type="EnsemblBacteria" id="AAC65048">
        <property type="protein sequence ID" value="AAC65048"/>
        <property type="gene ID" value="TP_0052"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75272">
        <property type="protein sequence ID" value="AGN75272"/>
        <property type="gene ID" value="TPANIC_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0052"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.48"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_12"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="5">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="244"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="348" mass="38013" checksum="45250886C59B148E" modified="1998-11-01" version="1">MYCVSRECNLVQELCTIRQARMYARALFQDAPCLRGQNTPLLDADLILSKLLAKPRAWILAHQQDEIASVAHEFKRLVHLRCRGRALAYLTREKEFFGLRFRVTRATLIPKPDTELLVESVLAHVASQMMKPRSVSVHKDTSALPVLKIFEACTGCGCIAIALMHMLRARGTPPLYVIASDICMRALAVARYNARRLLDVSANSRVRFVHADVRAPIPFFSPSEGTDVVQERGVCVPYDVICANPPYVPSAQARALLQDGRGEPLGALDGGADGLDLVRAFAHHSAAALKEGGCVFCEVGSNHAQRAARIFQAAGFATVKISKDLSGKERLISGILRSQSRAVTAPSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83097</accession>
    <name>DNAB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Replicative DNA helicase</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaB</name>
        <name type="ordered locus">TP_0058</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
        </interactant>
        <interactant intactId="EBI-1582316">
            <id>O83047</id>
            <label>dnaA</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
        </interactant>
        <interactant intactId="EBI-1582351">
            <id>O83970</id>
            <label>dnaX</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
        </interactant>
        <interactant intactId="EBI-1198251">
            <id>O83089</id>
            <label>TP_0050</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
        </interactant>
        <interactant intactId="EBI-1198269">
            <id>O83130</id>
            <label>TP_0092</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71370">
        <property type="entry name" value="B71370"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83097"/>
    <dbReference type="SMR" id="O83097"/>
    <dbReference type="IntAct" id="O83097">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0058"/>
    <dbReference type="EnsemblBacteria" id="AAC65054">
        <property type="protein sequence ID" value="AAC65054"/>
        <property type="gene ID" value="TP_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0058"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_2_12"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000102033" description="Replicative DNA helicase">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="SF4 helicase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="438" mass="47796" checksum="14F1D14AA29ACFFA" modified="1998-11-01" version="1">MPGMPNPTQELKGKIPPHNLEAERAVLGAVLLDDSALSTATEQLSASSFYSAAHQRIFQALVELSDLGQRPDILVLSEHLRSCEALDFVGGSAYVASLTDAVPSAANVEYYTRIVCDAAMRRSLLKVARIITAEAFNDTVSGNIVLETAQREIYDLTNARRVATFKLLKNLIPDLVNTIETRYRNQSDLVGIATGLTALDNLTGGFQNSELIVIGARPSMGKTALAMTMASNIAIRQRIPTAFFSLEMSNLLLMQRLIAAESGVSATNLRKGLLQLSDFGRIQNAAGEMYDAPLYIVDVPNMKLLDLRAVARRLCVQEKIQIIFVDYLGLIVADNPFAPRYEQFAAISQSLKSLARELDIPIVALSQVGRPAEGSAPNLADIRGSGAIEQDADVVMFLHRDRNETETQLILAKQRNGPIGTVELEFQASFTRFVCKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83104</accession>
    <name>O83104_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71371">
        <property type="entry name" value="A71371"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0065"/>
    <dbReference type="EnsemblBacteria" id="AAC65059">
        <property type="protein sequence ID" value="AAC65059"/>
        <property type="gene ID" value="TP_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0065"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_12"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="195" mass="22595" checksum="52543AEA2D12DC3A" modified="1998-11-01" version="1">MLKNHVLRCPDGPIRPAMDRMRESLFAILGDMRGCSFLDLFAGSGVCGLEAYSRGAYPVVFVEWNVRSFSVLLQNVQVALCRLECRCMAVERYIARARTLFHFVYLDPPFPYRFHAELLQRLSRASLCREGSVVMVHRPREKKLADKIDSLVRTDQRVYGRSVVDFYRRIKPVLRRTETRCRILLFFVRGDAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83113</accession>
    <name>O83113_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter, periplasmic binding protein (Y4oP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71369">
        <property type="entry name" value="A71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881523.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83113">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0074"/>
    <dbReference type="EnsemblBacteria" id="AAC65069">
        <property type="protein sequence ID" value="AAC65069"/>
        <property type="gene ID" value="TP_0074"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75293">
        <property type="protein sequence ID" value="AGN75293"/>
        <property type="gene ID" value="TPANIC_0074"/>
    </dbReference>
    <dbReference type="GeneID" id="57878614"/>
    <dbReference type="KEGG" id="tpa:TP_0074"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.73"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_2_12"/>
    <dbReference type="OMA" id="PFWANTQ"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="469" mass="52369" checksum="32BE4C09437A3359" modified="1998-11-01" version="1">MCFARSRLFSRGAVGTVCCTVLFLACRVRTPSSVPLRSGSVRAAVPEATSFHWRRYAGTRLRVCFPYHASYRALKAIVPEFESLTGIAVEIDWLQYARMHDKQVLELSKPRGDYDLIAMLCTWKTEYASRGLLRSLDSFFQNPSLCMPHYDFEDLIPVYVETIGYVGGRKPWLGGPGAFLCAVPFGAETSILAYRKDIFHKYRIKVPENYDELLDACKRLRERAQLYGLASRGASGQQALHAYLLHAAPFGAKVLDDSLVPAFHRSRSIATLRWMQEMFAYGPPGMASFAQNEALQAFLQGQTGMYLDTNMIGPLVRDPTRSAIRPHHVGFALHPMAQVRAGEVGGFGLAIPHNSAAPEAAFLLLQWITAPQTGRRVVEQGALPFRQSQLADRALRARFAEFEVLERQLAHCDPDWRPIVPTWGELGTLLGIGINEVLTGVSEPEEAMSALVLPARRILRRHAHARYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83118</accession>
    <name>O83118_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ald_Xan_dh_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71369">
        <property type="entry name" value="F71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881528.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83118">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0079"/>
    <dbReference type="EnsemblBacteria" id="AAC65074">
        <property type="protein sequence ID" value="AAC65074"/>
        <property type="gene ID" value="TP_0079"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75298">
        <property type="protein sequence ID" value="AGN75298"/>
        <property type="gene ID" value="TPANIC_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0079"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.87"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_3_12"/>
    <dbReference type="OMA" id="GKRHGFH"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="740" mass="81779" checksum="7D8AE3DEE4D22ED6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83162</accession>
    <name>O83162_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease (ExoA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71362">
        <property type="entry name" value="B71362"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881574.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0125"/>
    <dbReference type="EnsemblBacteria" id="AAC65116">
        <property type="protein sequence ID" value="AAC65116"/>
        <property type="gene ID" value="TP_0125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75344">
        <property type="protein sequence ID" value="AGN75344"/>
        <property type="gene ID" value="TPANIC_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0125"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.127"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_3_1_12"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29742" checksum="38284EB60EB84523" modified="1998-11-01" version="1">MRPVQRIISWNVNGIRAIERKDFLSWLAREAPDVLCLQEIKAHESQLSAALRAPVWSAGAGGTYYTYFHSAQRPGYSGTALFSKRAPDAVRFFGVPAFDCEGRMLAARFGELTVVSAYFPNAQEGGKRLAYKLDFCAAFRAFCDEERTAGQHVILCGDYNIAHKEIDLAHPQENEGNPGFLPQERAWMDTFTEAGYADSFRAFCTEGQQYTWWSYRARARARNIGWRIDYQCVDQAFLARVTSSQILSEVTGSDHCPVCLTYAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83163</accession>
    <name>Y126_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0126</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0126</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">To T.pallidum TP_0733.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71362">
        <property type="entry name" value="C71362"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83163"/>
    <dbReference type="IntAct" id="O83163">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0126"/>
    <dbReference type="TCDB" id="1.B.6.10.2">
        <property type="family name" value="the ompa-ompf porin (oop) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65118">
        <property type="protein sequence ID" value="AAC65118"/>
        <property type="gene ID" value="TP_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0126"/>
    <dbReference type="HOGENOM" id="CLU_083340_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202192" description="Uncharacterized protein TP_0126">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="291" mass="31921" checksum="4963E1BD06EE67A3" modified="1998-11-01" version="1">MRTHDIPRSPLVGHKKNAAPDGIGASRACCPARENEPFKKGSTNSRGGGVEWSRSSTRRVRGSALERGMKQLKWWAVGPVLGICAGVWGAAHPVHADPWDTTAAGRSTIRLSAMGAVPLFQVDWCNSGRGDDRNANAQTNGHKYIYPAFSAALGFEHFVCRGLSLGIDASVQYHCSYPNNTYSPTTPYYYLAIPVALTAGYTVAFWRIRLPLTVGAGFNYQHYYTSTYYGLVLKAAAGCYFQLTEHWSLGVSATYSGVPRSCEKIIEEDRQQTNTRTAQFIAAGVDVRYHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83164</accession>
    <name>Y127_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0127</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0127</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To T.pallidum TP_0315, TP_0618 and TP_0619.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71362">
        <property type="entry name" value="D71362"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83164"/>
    <dbReference type="IntAct" id="O83164">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0127"/>
    <dbReference type="EnsemblBacteria" id="AAC65119">
        <property type="protein sequence ID" value="AAC65119"/>
        <property type="gene ID" value="TP_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0127"/>
    <dbReference type="HOGENOM" id="CLU_091716_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202193" description="Uncharacterized protein TP_0127">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="229" mass="24870" checksum="39C216395BC6FE88" modified="1998-11-01" version="1">MLGWGMDMSKSVMLCCLLSVQPCYAGYVFVSPKLGVYGEALGGPDTVGKAVKQADGTKIAPKIWYYAPRTPLFGVDIGYQADNGLLFRVNLDAALTRLMFRSQCVVGYSLRFGWGGGYVSIASGIECSATVDDAQYEPYTKNEQGTTVASNTVFPCTVLEALVRDPALTADYLLYGMQSCYAIPLHVGVSYYLAKRWGIECALTASLGISMRTDVRVPYAVRIGPVFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83186</accession>
    <name>O83186_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71361">
        <property type="entry name" value="H71361"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881598.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83186">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0151"/>
    <dbReference type="EnsemblBacteria" id="AAC65135">
        <property type="protein sequence ID" value="AAC65135"/>
        <property type="gene ID" value="TP_0151"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75370">
        <property type="protein sequence ID" value="AGN75370"/>
        <property type="gene ID" value="TPANIC_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0151"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.158"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069371_0_0_12"/>
    <dbReference type="OMA" id="PWYAVAG"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="339" mass="36905" checksum="E40C4FA05CF53349" modified="1998-11-01" version="1">MRTAEYKHAPFLYTGLSAGQNNSVLLALLVAHVFVVAAMRDTVALFSIVSTELGALSAALVQTLRTPHVPLSDSLVLGLLIGAVLPAHNSFLNTFCVAFCAVFFTRVLFGGKIGNWLNPIALAPVLLRLCTEGTSLPTSGRVSVVQGAMSYPLFYSALVEWDAAVRTWCNTQVFQPLGLTLPEGALSACVFTQAAAPGFRYPVLTLLAALCVYAVRARRYICSCAFLVVYSTLFFLPAHAHPATLVSLIKSGALFTAFFVLPEPDTSMRTNGGAWISGGLCAMCAFFLAKKNSSAPDMWGAHDMHLWSAILLTNIVQPLILRAESWYYYVRRRRYDVQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83205</accession>
    <name>Y175_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0175</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0175</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71358">
        <property type="entry name" value="D71358"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83205"/>
    <dbReference type="IntAct" id="O83205">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65165">
        <property type="protein sequence ID" value="AAC65165"/>
        <property type="gene ID" value="TP_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0175"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309644_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202206" description="Uncharacterized protein TP_0175">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <sequence length="210" mass="24239" checksum="03FB0A3B37A841DA" modified="1998-11-01" version="1">MNLITRVSVHSWSQVDLTHIIVQERVHFLHPLTHGSASQEIAQCYMPIIHGNFFVHYLQPWKAFFPTSEQKIAELTSQAMKIIRADFSVQVHFGKLWMRNALLNLRYAQIFTPKLPNINTQTEAIILGAGPSLEKGIEKIRSHRDVYTIFACDTAFPVCCTGGLMPDFFISIDPQYISYATHYVFIPFTGNCNIRHMRVSMRSTQFLFEW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83223</accession>
    <name>RS19_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsS</name>
        <name type="ordered locus">TP_0193</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71355">
        <property type="entry name" value="C71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881640.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83223"/>
    <dbReference type="SMR" id="O83223"/>
    <dbReference type="IntAct" id="O83223">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0193"/>
    <dbReference type="EnsemblBacteria" id="AAC65178">
        <property type="protein sequence ID" value="AAC65178"/>
        <property type="gene ID" value="TP_0193"/>
    </dbReference>
    <dbReference type="GeneID" id="57878731"/>
    <dbReference type="KEGG" id="tpa:TP_0193"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_12"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129932" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="95" mass="10816" checksum="5674789A3FD94648" modified="1998-11-01" version="1">MSRSVKKGPFVDKKLYKRVVEMNKAANQRNKKVIKSYSRCSTIIPEMVGFTISVHNGKSWIPVYITEEFVGHKLGEFSPTRVFRGHSGSDKKVGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83227</accession>
    <name>RL29_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmC</name>
        <name type="ordered locus">TP_0197</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71355">
        <property type="entry name" value="G71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881644.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83227"/>
    <dbReference type="SMR" id="O83227"/>
    <dbReference type="IntAct" id="O83227">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0197"/>
    <dbReference type="EnsemblBacteria" id="AAC65182">
        <property type="protein sequence ID" value="AAC65182"/>
        <property type="gene ID" value="TP_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0197"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_0_12"/>
    <dbReference type="OMA" id="YMDLRFK"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000130487" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="72" mass="8654" checksum="BF6163F9E244D63A" modified="1998-11-01" version="1">MGRGGCAQLSYSELLSRRRELERKYLDLRFQLVVEHVDNKLMKRILRRQIAAVNTFLRHKELTELEKRGVRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83260</accession>
    <name>Y232_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0232</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0232</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71349">
        <property type="entry name" value="B71349"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83260"/>
    <dbReference type="IntAct" id="O83260">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65231">
        <property type="protein sequence ID" value="AAC65231"/>
        <property type="gene ID" value="TP_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0232"/>
    <dbReference type="HOGENOM" id="CLU_3334255_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202216" description="Uncharacterized protein TP_0232">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <sequence length="38" mass="3915" checksum="D5F09C4463F5156A" modified="1998-11-01" version="1">MYCTRCVFAGARGGERSPAAVLSVGKIPAPIVISGYLC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83262</accession>
    <name>RL33_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmG</name>
        <name type="ordered locus">TP_0234</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71349">
        <property type="entry name" value="D71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881682.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83262"/>
    <dbReference type="SMR" id="O83262"/>
    <dbReference type="IntAct" id="O83262">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0234"/>
    <dbReference type="EnsemblBacteria" id="AAC65222">
        <property type="protein sequence ID" value="AAC65222"/>
        <property type="gene ID" value="TP_0234"/>
    </dbReference>
    <dbReference type="GeneID" id="57878775"/>
    <dbReference type="KEGG" id="tpa:TP_0234"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_12"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000170259" description="50S ribosomal protein L33">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="56" mass="6820" checksum="1636DC3500D1F4B1" modified="1998-11-01" version="1">MAKRTAVELIALQCTGCKRRNYTTSRNRRNVQEKLELRKYCPFERRRVLHREAKIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83263</accession>
    <name>SECE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secE</name>
        <name type="ordered locus">TP_0235</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71349">
        <property type="entry name" value="E71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881683.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83263"/>
    <dbReference type="SMR" id="O83263"/>
    <dbReference type="IntAct" id="O83263">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0235"/>
    <dbReference type="EnsemblBacteria" id="AAC65223">
        <property type="protein sequence ID" value="AAC65223"/>
        <property type="gene ID" value="TP_0235"/>
    </dbReference>
    <dbReference type="GeneID" id="57878777"/>
    <dbReference type="KEGG" id="tpa:TP_0235"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_8_0_12"/>
    <dbReference type="OMA" id="WKECIGE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000104191" description="Protein translocase subunit SecE">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <sequence length="59" mass="6789" checksum="9AC35BA8F48B2A7F" modified="1998-11-01" version="1">MLKFAKFRRECVAEFRRVVWPARTQVHTAVKVVLVSTVVMALFLGLIDALFVALLSFFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83267</accession>
    <name>RL10_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplJ</name>
        <name type="ordered locus">TP_0239</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71350">
        <property type="entry name" value="A71350"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881687.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83267"/>
    <dbReference type="SMR" id="O83267"/>
    <dbReference type="STRING" id="243276.TPANIC_0239"/>
    <dbReference type="EnsemblBacteria" id="AAC65227">
        <property type="protein sequence ID" value="AAC65227"/>
        <property type="gene ID" value="TP_0239"/>
    </dbReference>
    <dbReference type="GeneID" id="57878781"/>
    <dbReference type="KEGG" id="tpa:TP_0239"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_2_12"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154739" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="180" mass="19566" checksum="9CE3B8A3A35C49DD" modified="1998-11-01" version="1">MAVRARRLQPAKVAAVESLTRDLGEASSYIFTEYRGLTVEQLTALRRALREFSCVYRVVRNNFANIAFTSLNMTVGEYLVGPTAIALVDTEHANGVARVLFDFAKEVPALVVKGAILDGEVFDASKVEAYSKLPGKKELVSMFLSALNATTVKFVRVLQAVMDKRDEGVEVSVVSGGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83275</accession>
    <name>O83275_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase (AmiA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71348">
        <property type="entry name" value="B71348"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881695.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83275"/>
    <dbReference type="IntAct" id="O83275">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0247"/>
    <dbReference type="EnsemblBacteria" id="AAC65234">
        <property type="protein sequence ID" value="AAC65234"/>
        <property type="gene ID" value="TP_0247"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75459">
        <property type="protein sequence ID" value="AGN75459"/>
        <property type="gene ID" value="TPANIC_0247"/>
    </dbReference>
    <dbReference type="GeneID" id="57878789"/>
    <dbReference type="KEGG" id="tpa:TP_0247"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.251"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_0_0_12"/>
    <dbReference type="OMA" id="QIRPVHH"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="199"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="357" mass="39810" checksum="C46ED7EDB3AEFB71" modified="1998-11-01" version="1">MHWYFDRVSRARGIMKFLRSCLIGGVFFFALCLSADEAFVSAMKLARTLNVSVSWNPLSQTILFSKGERRVQCRVGQVLALLDGSEVLMIDPPVVKDAVVYVSGGFAERLRKVFGYSSHQPEHRVGAVLIDPGHGGKDWGTKGSYREQGKTVVVKEKDIALRASQNIYDLLTARYPDRKIIMTRKGDSYLTLEERVAMANGVKLGKYEAILYVSVHANFSWNTKASGFEVWYLPPEYRRSILDKNAASKEVLPILNSMLEEEFTMESIMIARSIADGMQASVGAQSKNRGVKEEAWFVVRNAKMPSVLVELGFVSNPVEARLLNDADYLKRCAQGIYNGLVSFITYFEGSGGFTGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83285</accession>
    <name>O83285_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Catabolite gene activator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71347">
        <property type="entry name" value="B71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881710.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0261"/>
    <dbReference type="EnsemblBacteria" id="AAC65248">
        <property type="protein sequence ID" value="AAC65248"/>
        <property type="gene ID" value="TP_0261"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75473">
        <property type="protein sequence ID" value="AGN75473"/>
        <property type="gene ID" value="TPANIC_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0261"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.265"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846407_0_0_12"/>
    <dbReference type="OMA" id="RYLTYYP"/>
    <dbReference type="OrthoDB" id="477513at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="347" mass="38313" checksum="BEDA46BF53CF0704" modified="1998-11-01" version="1">MGATLFLGVAWKTEADVPKAIQYKANSVIYFSGDLDDRVMILNKGHVALTFADVETGSQVTEYIKTGEFFGVKSALGNFPREENAITLVDSIVYAFGSQEFEAFAQTNIRIVMKMLKVFSRQLRSVHRQLESLLDSQEETNNEEGLYTVARAFHASEHYLAASQVAQRYRELYPDGKHRHDIASMLESADGTVGRGFEEAGAQGSDAGFEVPSAFAESAVDSEVGDLRAAELLEQQGKWGEAYEHYRLGCASNGGVGAEAAYLGAGRCLFEQREFVRSIQTFTECITRNPKSTRLAEVLMYLGQCYQGMGRPDKAISFYDKALSTAPESLVPRIKELQRSCEEASHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83288</accession>
    <name>DEOC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="1">DERA</shortName>
            <ecNumber evidence="1">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="1">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoC</name>
        <name type="ordered locus">TP_0264</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71347">
        <property type="entry name" value="E71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881713.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83288"/>
    <dbReference type="SMR" id="O83288"/>
    <dbReference type="STRING" id="243276.TPANIC_0264"/>
    <dbReference type="EnsemblBacteria" id="AAC65251">
        <property type="protein sequence ID" value="AAC65251"/>
        <property type="gene ID" value="TP_0264"/>
    </dbReference>
    <dbReference type="GeneID" id="57878805"/>
    <dbReference type="KEGG" id="tpa:TP_0264"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_12"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000057282" description="Deoxyribose-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="218" mass="23470" checksum="6228CE8DFDFBB206" modified="1998-11-01" version="1">MELNAYIDHTLLRPSASEAEVLRLCQEAQHYRFASVCVNPCHVALAAGAVRGTAVRVCSVIGFPFGTHVTEVKCAEAQRALDDGAQELDMVVRIDKVCAGEREVVEREIAQVAARCHARGAIVKVIVETALLDEMHIAFACSCVEAGHADFIKTSTGYASRGGTEGDIQCFKKYLKGETKIKASGGIRTRAQAQRFIELGCARIGTSNGVAIMEERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83310</accession>
    <name>O83310_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71344">
        <property type="entry name" value="A71344"/>
    </dbReference>
    <dbReference type="IntAct" id="O83310">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65268">
        <property type="protein sequence ID" value="AAC65268"/>
        <property type="gene ID" value="TP_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0286"/>
    <dbReference type="HOGENOM" id="CLU_2037038_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13163" checksum="F6CBF36F6519C2EF" modified="1998-11-01" version="1">MMSTIPIIFNEKNVAHTVVGGQLCPVASAFLGAVVLNRGVRWNRAEFFAQLTTLGIAPIVSVERSAAAPDVTGLAERFPFVKFITPLECISVGEMINLGVAELDVMYVLVLWSDMRIDPQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83316</accession>
    <name>Y293_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0293</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0293</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71344">
        <property type="entry name" value="H71344"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83316"/>
    <dbReference type="STRING" id="243276.TPANIC_0293"/>
    <dbReference type="EnsemblBacteria" id="AAC65284">
        <property type="protein sequence ID" value="AAC65284"/>
        <property type="gene ID" value="TP_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0293"/>
    <dbReference type="HOGENOM" id="CLU_2977959_0_0_12"/>
    <dbReference type="OMA" id="CVRSLCD"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202228" description="Uncharacterized protein TP_0293">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <sequence length="58" mass="6822" checksum="31F7C0A3066A64C0" modified="1998-11-01" version="1">MRMTRVRSLCLAYARCVRLGVFRCISLRGWAPYRAVETVLVQSALTSVERLHEMFRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83329</accession>
    <name>O83329_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PASTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71339">
        <property type="entry name" value="E71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881756.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83329">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0307"/>
    <dbReference type="EnsemblBacteria" id="AAC65296">
        <property type="protein sequence ID" value="AAC65296"/>
        <property type="gene ID" value="TP_0307"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75511">
        <property type="protein sequence ID" value="AGN75511"/>
        <property type="gene ID" value="TPANIC_0307"/>
    </dbReference>
    <dbReference type="GeneID" id="57878843"/>
    <dbReference type="KEGG" id="tpa:TP_0307"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.307"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066816_0_0_12"/>
    <dbReference type="OMA" id="LIPHIEF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37095" checksum="415E7B297E6B9AFF" modified="1998-11-01" version="1">MDDGPLRVVVLTSFVILVVVCAVALCTFFVFLKSPDQVMTPHIVGKDFVSAAIEMQAKELYPRVQLRFSTREKPGVVLEQNPPAGAIVKAGRYVDLVVSQQAVTTHVEDYRGLQVEEAVARIAAAEVERRISVKTPHLYRFSTGAAGTILEQDPAPGAVLSADVELRFVVSKGSEREQTTVPLLVGYSLPELYRVMAQTALTLQFTVSPPSPSGERKDGEARGRTRANAQDYARVSAQDHDPGSRVEAFRAMQVQVLFPERGEAHEIYGILALDLPRYPYPMSCVLDVQYPGGVRTALAMFQHPGGRFTIPYGLPAGATLFLTVGGKELFSGEVGALPHAGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83348</accession>
    <name>MUTS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mutS</name>
        <name type="ordered locus">TP_0328</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71339">
        <property type="entry name" value="C71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881776.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83348"/>
    <dbReference type="SMR" id="O83348"/>
    <dbReference type="IntAct" id="O83348">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0328"/>
    <dbReference type="EnsemblBacteria" id="AAC65315">
        <property type="protein sequence ID" value="AAC65315"/>
        <property type="gene ID" value="TP_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="57878859"/>
    <dbReference type="KEGG" id="tpa:TP_0328"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_3_12"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115163" description="DNA mismatch repair protein MutS">
        <location>
            <begin position="1"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="626"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="900" mass="99705" checksum="0972F3B6CBC088FE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83360</accession>
    <name>O83360_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Folylpolyglutamate synthetase (FolC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71338">
        <property type="entry name" value="B71338"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881788.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0340"/>
    <dbReference type="EnsemblBacteria" id="AAC65325">
        <property type="protein sequence ID" value="AAC65325"/>
        <property type="gene ID" value="TP_0340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75538">
        <property type="protein sequence ID" value="AGN75538"/>
        <property type="gene ID" value="TPANIC_0340"/>
    </dbReference>
    <dbReference type="GeneID" id="57878870"/>
    <dbReference type="KEGG" id="tpa:TP_0340"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.338"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_12"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="3">
        <location>
            <begin position="344"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="490" mass="54652" checksum="18A5BDE9E3B5E94D" modified="1998-11-01" version="1">MSDLSNVHQFSFPARIAASSVPHIIVRPSAHGVSHIPVHSFQDFYAWVERIRTLEKMPPSGTPPLHRMTALARALCNPHNAYQSIHVAGTKGKGSSARMLAAILNEIGFNTGLYASPHVMDPRERITRAGVFFSPAEYASACTHVYHTVKKTENLRDYGQATWFELITLLAFMLFAQQRMEWSVFEVGLGGRLDATNIICPSICLLLPIEQEHTRILGTRIKSIAKEKGGIIKPYTPIFCFDQPEDALHVFKHIAREKHAPFFYLPDMVTHIESSIKHFTHTATLSFNAAHPVGRLFARNIHCTLALCDIVQAKNAALAACAAKYLFPTVSETLIERGLSRAYVPARFEIMQEDPLIVIDGAHTTQSIRCACRTFSSLLPSAQYILLFACAADKAVSQFPPLFSHAASEIFLTIPGTSKHADIQKTYHAFRTTFHQTVPIFWSEDFASIISRALYASFAQRKALLAIGSFYLAAEVKRIYARTCHTLPNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83396</accession>
    <name>Y381_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0381</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0381</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71330">
        <property type="entry name" value="G71330"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881829.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83396"/>
    <dbReference type="IntAct" id="O83396">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0381"/>
    <dbReference type="EnsemblBacteria" id="AAC65382">
        <property type="protein sequence ID" value="AAC65382"/>
        <property type="gene ID" value="TP_0381"/>
    </dbReference>
    <dbReference type="GeneID" id="57878908"/>
    <dbReference type="KEGG" id="tpa:TP_0381"/>
    <dbReference type="eggNOG" id="COG5522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088526_2_0_12"/>
    <dbReference type="OMA" id="KEINAMF"/>
    <dbReference type="OrthoDB" id="1208418at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011737">
        <property type="entry name" value="CHP02206_TP0381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09529">
        <property type="entry name" value="Intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02206">
        <property type="entry name" value="intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202246" description="Uncharacterized protein TP_0381">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="238" mass="27120" checksum="2158C2FAA47D693D" modified="1998-11-01" version="1">MLGAELADTGLFVRFGALHFAIASVAVLLSALFVLLPFALPRLLAHKNLARAGVAILFLRLGLMLCGTLLDGRSWRNELPFHLCPAALISGSLYFITRRPIFFNLLYFWHFGSFVAVLYPDLTRAHTILYAYLFMLTHCLEPAMVVFSLLHLRERISKRGLQCAVLGFLLLAANALFWNRRLGANYLFISKYPLEILRVIRPFFVYQLLFVSALCLLMLVLYLPFRPSQHGRNQLFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>O83406</accession>
    <name>O83406_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase/recombinase (CodV)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71332">
        <property type="entry name" value="A71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881839.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83406">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0391"/>
    <dbReference type="EnsemblBacteria" id="AAC65375">
        <property type="protein sequence ID" value="AAC65375"/>
        <property type="gene ID" value="TP_0391"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75585">
        <property type="protein sequence ID" value="AGN75585"/>
        <property type="gene ID" value="TPANIC_0391"/>
    </dbReference>
    <dbReference type="GeneID" id="57878917"/>
    <dbReference type="KEGG" id="tpa:TP_0391"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.391"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_12"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="107"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="306" mass="34343" checksum="1553E38887B6D4A6" modified="1998-11-01" version="1">MKDVDIRVQSFYAYLISAEAHALLTARTYVTTLMLFQKNLDPPCNIESANAHDCVRFIEKRSAAGVSGKTIAKDMAALHAFYQFLILEQVRPDNPMQDVDAPRRAYSLPRVLSPEQVNTFLQSIPLCTPGGVRDRALFELIYAAGLRVSEAVSLSLSDIFFAERLLKVTGKGNKERMAPFGEQACYFLMQYIREARVRFTSAKHPENSEKKGAVFLNRQGGRLSRKGIWKRLQDIEIRSGVETHVHTFRHSYATHLLAGGVDLHSVQCLLGHADIATTQVYTHVENGQLEACHRACFSSEGLRDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83411</accession>
    <name>O83411_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71328">
        <property type="entry name" value="C71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881844.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83411">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0396"/>
    <dbReference type="EnsemblBacteria" id="AAC65384">
        <property type="protein sequence ID" value="AAC65384"/>
        <property type="gene ID" value="TP_0396"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75590">
        <property type="protein sequence ID" value="AGN75590"/>
        <property type="gene ID" value="TPANIC_0396"/>
    </dbReference>
    <dbReference type="GeneID" id="57878922"/>
    <dbReference type="KEGG" id="tpa:TP_0396"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.396"/>
    <dbReference type="eggNOG" id="COG1815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125463_3_1_12"/>
    <dbReference type="OMA" id="NIQAHHF"/>
    <dbReference type="OrthoDB" id="1914857at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15646" checksum="FBBF206E38C94AE4" modified="1998-11-01" version="1">MNSFTRTVDLLHRALDVNALRYEVTANNLANAEVPGFKRTDVNFEAELKRALDSQRNETSFFKQATAGTNMLSSDVIDYRSVRPRRVLDYLTDVKANGNNVDAEQEAMHVLKIQMHYQMLSQMVGFQYRQVESVLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83413</accession>
    <name>FLIE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliE</name>
        <name type="ordered locus">TP_0398</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71328">
        <property type="entry name" value="E71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881846.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83413"/>
    <dbReference type="SMR" id="O83413"/>
    <dbReference type="IntAct" id="O83413">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0398"/>
    <dbReference type="EnsemblBacteria" id="AAC65386">
        <property type="protein sequence ID" value="AAC65386"/>
        <property type="gene ID" value="TP_0398"/>
    </dbReference>
    <dbReference type="GeneID" id="57878924"/>
    <dbReference type="KEGG" id="tpa:TP_0398"/>
    <dbReference type="eggNOG" id="COG1677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147249_4_1_12"/>
    <dbReference type="OMA" id="VRIDAFF"/>
    <dbReference type="OrthoDB" id="1581972at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105569" description="Flagellar hook-basal body complex protein FliE">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="124" mass="13703" checksum="A7A366675CFD773A" modified="1998-11-01" version="1">MTPVGTITNSANVYKVPSLRKVPEIGPVSVESVRQRMRGNTDAVDQAVNKKAMSFEQTLLRAFDQVNQKQQKTAELTEQMIVDPESVDVHDVTVAMAEASMSLKIAQTVIDKVLKSWNDVTTAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83416</accession>
    <name>FLIH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar assembly protein FliH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliH</name>
        <name type="ordered locus">TP_0401</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Needed for flagellar regrowth and assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliH family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71328">
        <property type="entry name" value="H71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881849.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83416"/>
    <dbReference type="SMR" id="O83416"/>
    <dbReference type="IntAct" id="O83416">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0401"/>
    <dbReference type="PRIDE" id="O83416"/>
    <dbReference type="EnsemblBacteria" id="AAC65389">
        <property type="protein sequence ID" value="AAC65389"/>
        <property type="gene ID" value="TP_0401"/>
    </dbReference>
    <dbReference type="GeneID" id="57878927"/>
    <dbReference type="KEGG" id="tpa:TP_0401"/>
    <dbReference type="eggNOG" id="COG1317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077967_0_0_12"/>
    <dbReference type="OMA" id="CIIETDF"/>
    <dbReference type="OrthoDB" id="1285795at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000180895" description="Flagellar assembly protein FliH">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="309" mass="35339" checksum="213978124489C81F" modified="1998-11-01" version="1">MPKMIFRNHEVKNLDQFLLLDLSRSFGVEPQIEEVQSEPVCPVPDMREVQEEVELFRKSWEEEQVQLRARAEREAQDLKERVEEEITAYREQCTQEADRILAQAKEQSELQISEAQQQAERMIAEAETSRQKICDHSKAEGIRLGKEEGFRAGQEEVRYLTERLHKMIEEVMGRRQGILRETERQIVDLVLLMTRKVVKVISENQRAVISANVVHALRKVRTRGAVTLRVNLADVELVTQHKQEFIAAVERVDDLTVVEDTSVGRGGCVVETDFGEIDARVASQLHELEQRVLEVAPIVVSSMSASKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83429</accession>
    <name>O83429_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-alanine glycine permease (DagA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71327">
        <property type="entry name" value="D71327"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881862.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83429">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0414"/>
    <dbReference type="EnsemblBacteria" id="AAC65402">
        <property type="protein sequence ID" value="AAC65402"/>
        <property type="gene ID" value="TP_0414"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75609">
        <property type="protein sequence ID" value="AGN75609"/>
        <property type="gene ID" value="TPANIC_0414"/>
    </dbReference>
    <dbReference type="GeneID" id="57878940"/>
    <dbReference type="KEGG" id="tpa:TP_0414"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.414"/>
    <dbReference type="eggNOG" id="COG1115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024867_1_2_12"/>
    <dbReference type="OMA" id="VSMTQVF"/>
    <dbReference type="OrthoDB" id="883596at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="451" mass="47349" checksum="D0F029B27CF71C47" modified="1998-11-01" version="1">MGVVEWVGEWMHAVVWSFPMVVLLLGTGCYVTVCMKFFPVVRLWYVLRQTIGGRGGKKGGSGEVSAFRAVSTALAATLGSGNIVGVATAIAIGGPGAIFWIWVTGIFGMGTKFVEVVLAVYYRRQTGDGRFVGGPMYYLKDGVGVPGAGVLASLFCIFSVIASFGIGNMTQSNSVALVFEDVFCVDVRVTGAVLMVLVGLVSVGGLKSISWVTGVMVPGMAILYVCVGVVLVCCNTRQLVPVCWDIVSGAFAGTAAVGGFAGSVVRQAIAVGISRGVAVNEAGLGTAPIAHAAAITDHPVRQGLWGIFEVFVGTMVVSSVTAFAILLTGVWQGGASGAALTVQSFERGLPFGIGQYVVGVSVPLFAFTTMLGWLYYGERCAEFLCGPRVCPLYRAVWLPFVYVGAVGSLSSVWNISDAFNGLMALPNLVGLLFLARQGMRLREEFFAQQEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83430</accession>
    <name>Y415_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0415</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0415</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71327">
        <property type="entry name" value="E71327"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83430"/>
    <dbReference type="STRING" id="243276.TPANIC_0415"/>
    <dbReference type="EnsemblBacteria" id="AAC65407">
        <property type="protein sequence ID" value="AAC65407"/>
        <property type="gene ID" value="TP_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0415"/>
    <dbReference type="HOGENOM" id="CLU_1554609_0_0_12"/>
    <dbReference type="OMA" id="HRVYLLW"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202250" description="Uncharacterized protein TP_0415">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <sequence length="177" mass="19319" checksum="F015A9B091840FBA" modified="1998-11-01" version="1">MRSRKGRGARRWMSHENGVAVHGNVGVEGARKFLESRCVLKEAEGGEICWSVIVEKKVDDIRVKGEQHGGFLCAGMWGDFVGTGEERIAGRDRTEEAHVTGKEGKVFRRQGVEGGTLRVRLEKCRIVGWGMYGGPGVVRVFCARSGAHSALSAKRAQAAYLAMWPSIGCISFRVCPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83434</accession>
    <name>SURE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>5'-nucleotidase SurE</fullName>
            <ecNumber>3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">surE</name>
        <name type="ordered locus">TP_0419</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71328">
        <property type="entry name" value="A71328"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83434"/>
    <dbReference type="SMR" id="O83434"/>
    <dbReference type="IntAct" id="O83434">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0419"/>
    <dbReference type="EnsemblBacteria" id="AAC65406">
        <property type="protein sequence ID" value="AAC65406"/>
        <property type="gene ID" value="TP_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0419"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_3_0_12"/>
    <dbReference type="OMA" id="YWRWGPR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000111848" description="5'-nucleotidase SurE">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="187" mass="19541" checksum="1315F46F35DDF24E" modified="1998-11-01" version="1">MRILLTNDDGYQAAGIRALHAALKAAPEGYEVTVVAPDRDRSAVSHGITTLEPVTVKEVEPGIWSCSGTPVDCVNRALRQVCVGTPPDVVVSGINEGENLGTDIVFSGTVAAARQAVMYGIAGIAASLLPVSDFGTGCRFQALARFVARHVRALAALSSEDVLVNINARSAQAYARACYARVASSDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83463</accession>
    <name>Y449_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0449</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0449</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71325">
        <property type="entry name" value="A71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881897.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83463"/>
    <dbReference type="SMR" id="O83463"/>
    <dbReference type="IntAct" id="O83463">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0449"/>
    <dbReference type="EnsemblBacteria" id="AAC65437">
        <property type="protein sequence ID" value="AAC65437"/>
        <property type="gene ID" value="TP_0449"/>
    </dbReference>
    <dbReference type="GeneID" id="57878973"/>
    <dbReference type="KEGG" id="tpa:TP_0449"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389674_0_0_12"/>
    <dbReference type="OMA" id="PGENERI"/>
    <dbReference type="OrthoDB" id="1906165at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014249" description="Uncharacterized lipoprotein TP_0449">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="196" mass="22570" checksum="67DE09899A6FF70B" modified="1998-11-01" version="1" precursor="true">MNGKQCFCFFLFHLFYTGLFACGKPESSLAPEYFDLAHAYVQLHRYDEARDYYMRAARDPAYYHAAQYNFARVCGLQNDWKTAVHALQPLYDADSANATIAAAYAYALLSFGETARALLLYQQLYERDQKNTQRILEYANVLVHAKKYIQAVEFLRQKKSLLSEAEDVRVLQSIVRKLKDSVPPHLIADFVSTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83472</accession>
    <name>O83472_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71320">
        <property type="entry name" value="E71320"/>
    </dbReference>
    <dbReference type="IntAct" id="O83472">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0459"/>
    <dbReference type="EnsemblBacteria" id="AAC65447">
        <property type="protein sequence ID" value="AAC65447"/>
        <property type="gene ID" value="TP_0459"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75653">
        <property type="protein sequence ID" value="AGN75653"/>
        <property type="gene ID" value="TPANIC_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0459"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.459"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_12"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="261" mass="29216" checksum="31A643E33CDA680B" modified="1998-11-01" version="1">MCRLQPFFRLRLQVYLARSGCASRRACEALIASGRVTVDGQTVTTQGRTVCAQNVVCVDGTVVQLERVQRYVLLYKPVGYICSLAPQFPAGYAHTQVRAGPSKQEYARAIDLVQPAYQERLYHIGRLDVRSEGALLFTNDGSFAQALGHPRSGIEKEYIVETREPVPAALLSSFVRGVWVEGCRYRCVRARHLAAQCVQLVLVEGKKREIRVVFEAWGQDVVRLVRVRIGRVRLGPLRPGAFRTMRLQEVAQLLQCAGCAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83478</accession>
    <name>Y465_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0465</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0465</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71321">
        <property type="entry name" value="C71321"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881914.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83478"/>
    <dbReference type="IntAct" id="O83478">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0465"/>
    <dbReference type="EnsemblBacteria" id="AAC65457">
        <property type="protein sequence ID" value="AAC65457"/>
        <property type="gene ID" value="TP_0465"/>
    </dbReference>
    <dbReference type="GeneID" id="57878988"/>
    <dbReference type="KEGG" id="tpa:TP_0465"/>
    <dbReference type="HOGENOM" id="CLU_1045615_0_0_12"/>
    <dbReference type="OMA" id="ENGRNDY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202258" description="Uncharacterized protein TP_0465">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="290" mass="32670" checksum="0C5771A7EA13FD08" modified="1998-11-01" version="1">MSQVLTVLHALSSPPWICLLSFNRMVLARQCAFVLVSCVVPCVAGAVLSSCMPFYARTEGLTLKRVYFEKAGKTDATLALHVTLEYPAPPEEYFYLEVEELRTGMRWVFGEKDTRVYIATDELHPGRRMLRVGGMQYPWGDFPAGTYVVYVRDSTGTYAQQRVTLGAGYPAHEPFPFSFSVDAQRWTLSAPAQPALVGPFTAHTHTSLVLLTRDYRTVAQHPLSLTSLPNARLSSPRVHTFEASMDALKTTHQDAYYLQCVVEDFQRSWRFISQPHRLYPEDALSEQAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83484</accession>
    <name>O83484_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71322">
        <property type="entry name" value="A71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881920.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83484">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0471"/>
    <dbReference type="EnsemblBacteria" id="AAC65460">
        <property type="protein sequence ID" value="AAC65460"/>
        <property type="gene ID" value="TP_0471"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75663">
        <property type="protein sequence ID" value="AGN75663"/>
        <property type="gene ID" value="TPANIC_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0471"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.503"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048872_0_0_12"/>
    <dbReference type="OMA" id="LITCAMV"/>
    <dbReference type="OrthoDB" id="734932at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="3">
        <location>
            <begin position="416"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="469" mass="52961" checksum="7D3AB58AD674CC8E" modified="1998-11-01" version="1">MAHLTFLLGCATMGGMSAYMALLAAAFSSSIVFLLVFLMRGFSIPRRQLLVEKSFRDGKYALAIKHAHAVLAKDPHNWAVRVLLGRAHLAEGKRDVALMELRAASSRAAFGKVVDEVEFRKTIAQLYLQFDQIEEALKEYTLLIRLDPTCADYHYRIGQLFERKNVTDRAAAYYRQCIGMDAAHPAAHAALGSLLLRSGHLAEARAELDTVLALEPANAEALFCQGQLLRKEREYAAALRSFEQASRSPVLRQKCFTERGCCYMDAKDVDRAIVEFDRALRCKSQSGENEDLQIRYLLASCYEKKRDVEKAIEQWEAINARSAGFKDVTIKLAQYQDIRLNDRMKEYLTLDGDSFFDLCQRIVSKALRLSIDSVQDVRGCCEIVATERDEKGWSNVRTQPKVVVFYREARVLDDSFLRAILERMKERGIARGVVVTSSSFSRAALSFAENRPLELLGKNELERLLDASS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83489</accession>
    <name>ACKA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetate kinase</fullName>
            <ecNumber evidence="1">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ackA</name>
        <name type="synonym">ack</name>
        <name type="ordered locus">TP_0476</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71319">
        <property type="entry name" value="B71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881925.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83489"/>
    <dbReference type="SMR" id="O83489"/>
    <dbReference type="STRING" id="243276.TPANIC_0476"/>
    <dbReference type="EnsemblBacteria" id="AAC65463">
        <property type="protein sequence ID" value="AAC65463"/>
        <property type="gene ID" value="TP_0476"/>
    </dbReference>
    <dbReference type="GeneID" id="57878997"/>
    <dbReference type="KEGG" id="tpa:TP_0476"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_12"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000107634" description="Acetate kinase">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <sequence length="448" mass="49195" checksum="7F4891EFE16F7500" modified="1998-11-01" version="1">MIILTLNCGSSSVKYQVYNWTERAVIAVGVVERVTQAGSVITHEVHGRENHVRESPCPTHTEAVQLIISTLTDAHVGVISDMSLIKAVGHRVLHAADRFVKSVVVTPDVLETFRSVQDLGPLHNPANIRGIEAAQAVIPSVPHCAIMDTAWHQTMPEASFMYAVPRQWYEEYAVRRYGFHGTSFLYTAKRASVILKKRAEDTNIIIAHIGNGASMCCVKNGVSFDTSMGITPLEGLIMGTRCGDCDPALAFYIMRKTGMSVSDIDTTLNKQSGLLGITGKYVDRRDVCAAMKNGDALARLAFDMEVHRIRKYFGAYVAALGKQPDALVFTAGVGEMCCDVRAAACAGLEHLGIRLDARKNELARTRNAETEISTDDSPVRILVIPTDEELVMTEDTYALMQGTYDVHTRFTYSFQDPTYVNKARAAGLKRDLEKNPALATIVVPRLDT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83491</accession>
    <name>G6PD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="1">G6PD</shortName>
            <ecNumber evidence="1">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zwf</name>
        <name type="ordered locus">TP_0478</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71319">
        <property type="entry name" value="D71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881927.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83491"/>
    <dbReference type="SMR" id="O83491"/>
    <dbReference type="IntAct" id="O83491">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0478"/>
    <dbReference type="EnsemblBacteria" id="AAC65465">
        <property type="protein sequence ID" value="AAC65465"/>
        <property type="gene ID" value="TP_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0478"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_12"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0313">Glucose metabolism</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000068137" description="Glucose-6-phosphate 1-dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <sequence length="515" mass="58032" checksum="22936A1609EBD798" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83504</accession>
    <name>O83504_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">TP_0491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71318">
        <property type="entry name" value="C71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881940.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0491"/>
    <dbReference type="EnsemblBacteria" id="AAC65478">
        <property type="protein sequence ID" value="AAC65478"/>
        <property type="gene ID" value="TP_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0491"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.525"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_12"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="344" mass="38364" checksum="691AE441CD6B46C2" modified="1998-11-01" version="1">MSIRTFSFTPSVRLRRIVLWGSLFCAGVLCLLCLCLLVGLAPVRPFVKKEHMFTVQSGVGARKVIHELRNARLIRSEWAARLYVFARALNFKAGSYAVSPAMSAVRILTMLDDVEQQRFIKVTVPEGLTVKKIAALLQDATVVSAAAFVEACTSAALRTRYKIPAPSVEGFLYPDTYFFSYQERAANVVGTMIENFLAKTSQLPSFPGDPVARFKTVILASIVEREYRVASEAARIAGVFYNRMKVNMGLQSCATVEYVITEIEGKAHPERLFFKDLEIDSPFNTYKCAGLPPAPISNPGLTALNAALHPEVHDFFYFRLTDPQRARTRSPRRWTSMIKLGSCC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83514</accession>
    <name>RODA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="1">PGT</shortName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Peptidoglycan polymerase</fullName>
            <shortName evidence="1">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rodA</name>
        <name type="synonym">mrdB</name>
        <name type="ordered locus">TP_0501</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71317">
        <property type="entry name" value="A71317"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881950.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83514"/>
    <dbReference type="SMR" id="O83514"/>
    <dbReference type="IntAct" id="O83514">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0501"/>
    <dbReference type="EnsemblBacteria" id="AAC65488">
        <property type="protein sequence ID" value="AAC65488"/>
        <property type="gene ID" value="TP_0501"/>
    </dbReference>
    <dbReference type="GeneID" id="57879022"/>
    <dbReference type="KEGG" id="tpa:TP_0501"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_12"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000062721" description="Peptidoglycan glycosyltransferase RodA">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <sequence length="433" mass="48345" checksum="19C2EAE3187A3669" modified="1998-11-01" version="1">MRIRGVSDFDYLLLLTMLALTSIGILFIYSSGVNSEGHVISREYLKQIVWAVMGVVLMLSVSMYDYHRFKDRTTLIFAGFILLLIYTRLFGRYVNGAKSWIGVGEFGIQISEFAKIAYILYLAHYLVYSQSEPMLKRFAKAGVITLLPMALILSQPDLGTASVYLPIFLVMCFIAGFPLRLIFAVVCVVLLTLLFTLLPLWEQTFLQYQGVATRIADSRMLSLFVFFSLSATSAVAVVGYLLSGRKYYYWITYALGMVSISYGASLLGVRVLKPYQMMRLIIFLNPEVDPLKAGWHIIQSMIAIGSGGAFGMGYLRGPQSHYRFLPQQSTDFIFSILSEEWGFVGGVIVFGLYLLFFLHTLSIMSHVDDLYGKLIASGVLGMFLFHFVVNVGMTMGIMPITGIPLLLLSYGGSSLWTAMIATGLLMSINARQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83520</accession>
    <name>CLPP1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 1</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP1</name>
        <name type="synonym">clpP-1</name>
        <name type="ordered locus">TP_0507</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71314">
        <property type="entry name" value="B71314"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881956.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83520"/>
    <dbReference type="SMR" id="O83520"/>
    <dbReference type="IntAct" id="O83520">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0507"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="AAC65495">
        <property type="protein sequence ID" value="AAC65495"/>
        <property type="gene ID" value="TP_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0507"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_12"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179704" description="ATP-dependent Clp protease proteolytic subunit 1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="203" mass="22346" checksum="52692B1AAB45ADB3" modified="1998-11-01" version="1">MRERMHNLVPYVIEQSGGGERSYDIFSRLLKDRIIFVDGEITDAVADLVVAQLLFLESQNPDKDISLYINSPGGAVTAGLAVYDTMQHICPEVQTICLGQASSMAAVLLAGGAPGKRFALPSSRVMIHQPWGGVQGQASDVCIQAQEILRLKTLTIAYFALHTGQSEEQVREDMERDFFLSAEQACSYGIVDTVMKRRKHAQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83521</accession>
    <name>CLPX_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">TP_0508</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71314">
        <property type="entry name" value="C71314"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881957.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83521"/>
    <dbReference type="SMR" id="O83521"/>
    <dbReference type="IntAct" id="O83521">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0508"/>
    <dbReference type="EnsemblBacteria" id="AAC65496">
        <property type="protein sequence ID" value="AAC65496"/>
        <property type="gene ID" value="TP_0508"/>
    </dbReference>
    <dbReference type="GeneID" id="57879031"/>
    <dbReference type="KEGG" id="tpa:TP_0508"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_12"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000160448" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="415" mass="45478" checksum="A416A8471D423D5A" modified="1998-11-01" version="1">MLRSKGDLVLGCSFCGKKEDERRRIVTGHGVSICNYCVERCAEYLRDRKPSALALMTKEEIPTPLELKAYLDQYVIGQDLAKRVLSVAVYNHYKRVAGRSLDIDSVLIEKSNVLLIGPTGSGKTLLAKTLSQKMKVPFAIADATTLTEAGYVGEDVENILLKLVQNANGDVALAERGIIFIDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTIASVPPQGGRKHPNQDMLRVDTSNILFICGGAFVGLDGIVGTRVCKNPVGFGADVKTVKERGLQLMHEDVIPDDLVKFGLIPEIIGRLPVTVALDALSKEDLRNILVRPRNAIVRQFEALFALDDVRLVFDEDALDAIAQQAIDQKTGARGLRSIVERLMLDAMFEAPSLKGKKELCITKKVVTQEEKASVRLVSERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83524</accession>
    <name>O83524_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor (CarD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71314">
        <property type="entry name" value="F71314"/>
    </dbReference>
    <dbReference type="IntAct" id="O83524">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0511"/>
    <dbReference type="EnsemblBacteria" id="AAC65499">
        <property type="protein sequence ID" value="AAC65499"/>
        <property type="gene ID" value="TP_0511"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75700">
        <property type="protein sequence ID" value="AGN75700"/>
        <property type="gene ID" value="TPANIC_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0511"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.506"/>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048259_1_1_12"/>
    <dbReference type="OMA" id="DMKVMIP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="35"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="208" mass="23789" checksum="6BEBA6DC7BA34A1E" modified="1998-11-01" version="1">MATRAWWSSLVFPLPLPTDFFPCLCYAGPMGKACAFRPHDHVVYPGQGVGQVQEISEKTFKNETLLYYVIYLEESDMTVLIPVDKAQELGIRTIVKRKEAERALRFLSEDFDPSPLDWKMRYQVNLNLFKSGGILDNAAVVRSLYHRSKVKELPIQERRLYDSAYRIFQDEMCFALGLRPPEVETLIHGYLEKAKENPVVSGTVDVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83528</accession>
    <name>O83528_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LptD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71315">
        <property type="entry name" value="B71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881964.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83528">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0515"/>
    <dbReference type="EnsemblBacteria" id="AAC65503">
        <property type="protein sequence ID" value="AAC65503"/>
        <property type="gene ID" value="TP_0515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75704">
        <property type="protein sequence ID" value="AGN75704"/>
        <property type="gene ID" value="TPANIC_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0515"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.510"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280171_0_0_12"/>
    <dbReference type="OMA" id="TSKIPEP"/>
    <dbReference type="OrthoDB" id="236451at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LptD" evidence="2">
        <location>
            <begin position="342"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="991" mass="112473" checksum="027B05896769B04C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83530</accession>
    <name>RUVC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber>3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ruvC</name>
        <name type="ordered locus">TP_0517</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71315">
        <property type="entry name" value="D71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881966.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83530"/>
    <dbReference type="SMR" id="O83530"/>
    <dbReference type="IntAct" id="O83530">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0517"/>
    <dbReference type="EnsemblBacteria" id="AAC65505">
        <property type="protein sequence ID" value="AAC65505"/>
        <property type="gene ID" value="TP_0517"/>
    </dbReference>
    <dbReference type="GeneID" id="57879040"/>
    <dbReference type="KEGG" id="tpa:TP_0517"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_12"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000183141" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="196" mass="20942" checksum="BD704CF266A5C714" modified="1998-11-01" version="1">MHAQNVDIAPGSTSTVSIIVGIDPGLESTGYGVIEAGGGSLRCLTYGVIVTQSNQPSAARLRHIFDTLQQVISIYQPQYCAVETIYFAKNVTSALCVAQARGVVLLAMAQQHISVAEYAPNAIKKAITGIAQAEKRQVQHLVKILLNLKDIPHPDHAADALAVAVTHVHCCMSSNYAVGSTRSRGAYVTLYKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="145" xmlns="http://uniprot.org/uniprot">
    <accession>O83532</accession>
    <name>O83532_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Response regulatory protein (AtoC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71315">
        <property type="entry name" value="F71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881968.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83532">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0519"/>
    <dbReference type="EnsemblBacteria" id="AAC65507">
        <property type="protein sequence ID" value="AAC65507"/>
        <property type="gene ID" value="TP_0519"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75708">
        <property type="protein sequence ID" value="AGN75708"/>
        <property type="gene ID" value="TPANIC_0519"/>
    </dbReference>
    <dbReference type="GeneID" id="57879042"/>
    <dbReference type="KEGG" id="tpa:TP_0519"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.514"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_12"/>
    <dbReference type="OMA" id="DWTGNIR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="458" mass="50963" checksum="A76CC326361D8B89" modified="1998-11-01" version="1">MKFSILVLDDEKNIREGLQMALEDEGYEVFTAEDGNTGVEIALKGDIDLIITDLKMPRMSGELVLQHVHAVLPDIPIIILTGHGTVENAVEAMHKGAYDFLTKPLDLNRLSLLVRRALQNRELIVQHRELIKQIGNRTSFENIVGESPAMNKVFDMVKKAAASKASVLITGESGVGKELIANAIHNLSPRKAKPLIKVHCASFAEGVLESELFGHERGAFTGAVNRMKGRFELAHEGSMFLDEIGEVSMAVQIKLLRVLQERSFERVGGRETIKVDVRVISATNRNLLEEIKRNLFREDLYYRLNVVHIHVPALRERKEDLPLLIATFLKEIAEENGKKITSIDPQAQSALHAYDWPGNIRQLRNCIESAVIMSSGPVIHIEDLSEPIRSLGETSSIRIPIGVSMEDAEKEIILQTLEAQKGNKSKTADVLGIGRKTLYLKLDQYTNTSFEPDAAAKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83541</accession>
    <name>VATA2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase alpha chain 2</fullName>
            <ecNumber>7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit A 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpA2</name>
        <name type="ordered locus">TP_0529</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71313">
        <property type="entry name" value="C71313"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881977.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83541"/>
    <dbReference type="SMR" id="O83541"/>
    <dbReference type="STRING" id="243276.TPANIC_0529"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65516">
        <property type="protein sequence ID" value="AAC65516"/>
        <property type="gene ID" value="TP_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0529"/>
    <dbReference type="eggNOG" id="COG1155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_12"/>
    <dbReference type="OMA" id="TAFVQVY"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144621" description="V-type ATP synthase alpha chain 2">
        <location>
            <begin position="1"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="242"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="605" mass="66740" checksum="65A2CB82B3822EE6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83556</accession>
    <name>O83556_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TP_0545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71312">
        <property type="entry name" value="F71312"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881992.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0545"/>
    <dbReference type="EnsemblBacteria" id="AAC65528">
        <property type="protein sequence ID" value="AAC65528"/>
        <property type="gene ID" value="TP_0545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75732">
        <property type="protein sequence ID" value="AGN75732"/>
        <property type="gene ID" value="TPANIC_0545"/>
    </dbReference>
    <dbReference type="GeneID" id="57879069"/>
    <dbReference type="KEGG" id="tpa:TP_0545"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.541"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_1_12"/>
    <dbReference type="OMA" id="MWDAAMA"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697294" description="D-galactose-binding periplasmic protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="10">
        <location>
            <begin position="28"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="354" mass="38365" checksum="7FA3AC97ABF7B39F" modified="1998-11-01" version="1">MKGTGMCVALLLCALGAGACKRSEKPTIGVVVYQYDNTLVARLRHILSTVGKKHARILIVDSQASQSIQNKHIDQFIARGVHGLAVNLVDHRAARTVIEKAQQARIPLVFFNRMPDLSDLNRYARAYYVGVKDDELGLLQSRLVAQYLERTPSADKNADGIIQCVVLKGDPDHKSGARCARYVCQALREIGLKGEIIGEAFALDSRVKGQAAMHTLIHTHGDRIEAVFANNDDAALGAIEALQSAGFFKENKRVPVVGIDATASALKAIEEDLMLGTVLNDVSSQGKAILNLLFALMGDSVPSIPAEDSTAFTHAGNGVAGRAAVFGTAEKQCVWIPYKVVTKENYRTVQNYLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-27" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83567</accession>
    <name>ASNA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnA</name>
        <name type="ordered locus">TP_0556</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71309">
        <property type="entry name" value="H71309"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882003.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83567"/>
    <dbReference type="SMR" id="O83567"/>
    <dbReference type="STRING" id="243276.TPANIC_0556"/>
    <dbReference type="EnsemblBacteria" id="AAC26560">
        <property type="protein sequence ID" value="AAC26560"/>
        <property type="gene ID" value="TP_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0556"/>
    <dbReference type="eggNOG" id="COG2502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071543_0_0_12"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="OrthoDB" id="487853at2"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00645">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195897" description="Aspartate--ammonia ligase">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <sequence length="330" mass="36856" checksum="7FF7623F5A963216" modified="1998-11-01" version="1">MEKSFILQQQGISFAKHTFTQKLMEHLGLIEVQGPLLSQVGDGIQDGLSGREKAVSVSVKQIPGTAFEVVHSLAKWKRHTLARYGFQDNEGLFVHMIALRPDEDFLDQVRSVCVDQWDWEKVVPVGSRNLAYLKDTVRKVYGALRESEVLVSERFGLRAFLPADIVFVQSEELVRRYPHLDSKGREDAICKEHGAVFLIGIGGVLSDGKPHDVRAPDYDDWTTPSEGEYKGLNGDILVWNPVLGRAFEVSSMGIRVDEGALRTQLALTGDEDSLACSWHQDLINGRLPQSIGGGIGQSRLAMLLLQRKHIGEVQASVWPRSVREEFENIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83582</accession>
    <name>Y572_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0572</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0572</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71309">
        <property type="entry name" value="B71309"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882019.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83582"/>
    <dbReference type="SMR" id="O83582"/>
    <dbReference type="STRING" id="243276.TPANIC_0572"/>
    <dbReference type="EnsemblBacteria" id="AAC65551">
        <property type="protein sequence ID" value="AAC65551"/>
        <property type="gene ID" value="TP_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0572"/>
    <dbReference type="eggNOG" id="COG2717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690609_0_0_12"/>
    <dbReference type="OMA" id="LASCHIF"/>
    <dbReference type="OrthoDB" id="1740020at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202275" description="Uncharacterized protein TP_0572">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="360" mass="38634" checksum="798365F156B76BCB" modified="1998-11-01" version="1">MSALFSLVAVYVLVCALHKQIKKYASVCYLGSACVSVAVVCVVWSGATKGNFGVRVLLHPLTSASFSTAIFTFVMCASVLKNGLLKQRVMGLRAELAITAAILTLGHNIAHGRDYLVRLCGSTGDLSTGFLVAGAVSMVLVLLMSILAVTSFKVVRRRMGAKTWKRVQRLAYLFYGLTYVHLSFILLPTALRGYIPSVVSYVLYTVIFATYALLRVRKALGKRKGACALCSAAVAVSFVAFVLGASHMVRHTRRAHTERTTRAKARKCSPAEMKDGVYEASAQGHNGKLSLRVTISQGRIEAVTVVGHSDDDPYASWAVEGVSAAIVGAQSTDVDVVSEATSTSEAIIRAVEKILQQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83603</accession>
    <name>O83603_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71306">
        <property type="entry name" value="C71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882040.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0594"/>
    <dbReference type="EnsemblBacteria" id="AAC65572">
        <property type="protein sequence ID" value="AAC65572"/>
        <property type="gene ID" value="TP_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0594"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.633"/>
    <dbReference type="eggNOG" id="COG4731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389679_0_0_12"/>
    <dbReference type="OMA" id="WGIGQKP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2147" evidence="2">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="202" mass="22098" checksum="89756AB966E8648D" modified="1998-11-01" version="1">MVPAFLQVVFPLVGCAHYILWGRAMRKVIVYGVVLCLCVPCFTASSDKAAQVPSVQKEMADPVEGIWKSVDDNTGKPTGVWRLYVQDGKLFGKILVCMGRAPNAAVVSCTRTYPDFSKKGNVANMPLVGTPFIYNLERTSPGSWGGGYVIDPASGKYYYCKINFIPADGRSYKVDTLQMRGEISWGIGQKPVLAQVFPDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83605</accession>
    <name>O83605_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polynucleotide adenylyltransferase (PcnB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71306">
        <property type="entry name" value="E71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882042.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0596"/>
    <dbReference type="EnsemblBacteria" id="AAC65568">
        <property type="protein sequence ID" value="AAC65568"/>
        <property type="gene ID" value="TP_0596"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75779">
        <property type="protein sequence ID" value="AGN75779"/>
        <property type="gene ID" value="TPANIC_0596"/>
    </dbReference>
    <dbReference type="GeneID" id="57879120"/>
    <dbReference type="KEGG" id="tpa:TP_0596"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.590"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_0_1_12"/>
    <dbReference type="OMA" id="DDPVRMI"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010206">
        <property type="entry name" value="PolA_pol_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01942">
        <property type="entry name" value="pcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="370" mass="41316" checksum="15871A38108D2F74" modified="1998-11-01" version="1">MLVRYSYDAKGRRLGRALVYTESEHGIPRQSVDAGAIRVVEALVGAGYETYIVGGAVRDLVAGRTPKDFDIVTGAVPSRIRRLFRNSRIIGRRFRIVHVSCGSQLYEVSTFRSRVGEGSVCVPGTLEEDAWRRDFSVNALYYDPLRNVVIDCVGGMVDLKRRRVRPLIPLRSIFVEDPVRMLRALKCSVMCESSIPFSVRRSIRRSVSLLGGCSPSRLTDEFVKILFSGRSAALVRALCGYQLLLYLQPSVHYFMRDVPCFESAFFASLRVLDQAFVSGRVKRVGQALTYVLRDFVGLVFGHADAPDEVYIRVYRACRSFVLPMNPPRVELEYAVRSCLGGRGFAARAACTPSGRLCARENGVRCVFSSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83618</accession>
    <name>SYN_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="1">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnS</name>
        <name type="ordered locus">TP_0609</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71302">
        <property type="entry name" value="F71302"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83618"/>
    <dbReference type="SMR" id="O83618"/>
    <dbReference type="STRING" id="243276.TPANIC_0609"/>
    <dbReference type="EnsemblBacteria" id="AAC65585">
        <property type="protein sequence ID" value="AAC65585"/>
        <property type="gene ID" value="TP_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0609"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_12"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176472" description="Asparagine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="523" mass="57798" checksum="93515E46900EE4C2" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83641</accession>
    <name>MSRAB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Peptide methionine sulfoxide reductase MsrB/MsrA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>Peptide methionine sulfoxide reductase MsrB</fullName>
                <ecNumber>1.8.4.12</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Peptide-methionine (R)-S-oxide reductase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Peptide methionine sulfoxide reductase MsrA</fullName>
                <shortName>Protein-methionine-S-oxide reductase</shortName>
                <ecNumber>1.8.4.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Peptide-methionine (S)-S-oxide reductase</fullName>
                <shortName>Peptide Met(O) reductase</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">msrAB</name>
        <name type="synonym">msrA</name>
        <name type="ordered locus">TP_0633</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12"/>
    <dbReference type="EC" id="1.8.4.11"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71300">
        <property type="entry name" value="G71300"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882079.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83641"/>
    <dbReference type="SMR" id="O83641"/>
    <dbReference type="STRING" id="243276.TPANIC_0633"/>
    <dbReference type="EnsemblBacteria" id="AAC65608">
        <property type="protein sequence ID" value="AAC65608"/>
        <property type="gene ID" value="TP_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0633"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_7_1_12"/>
    <dbReference type="OMA" id="FWGVEYH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138525" description="Peptide methionine sulfoxide reductase MsrB/MsrA">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MsrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Peptide methionine sulfoxide reductase A">
        <location>
            <begin position="127"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="291" mass="32802" checksum="3FF46CC8D37E8C15" modified="1998-11-01" version="1">MLANLQHLSDIQYRVTQQSATETPFKNEFWNSYQPGFYLDVVSGELLFLSEDKFDSGCGWPSFSAPAYARAVIEKEDRTHNMLRTEVRSRNANSHLGHVFKDGPPERGGLRYCINSAALRFVAREEGTALFAAGCFWSTEAYFRRVKGVLRVRVGYTGGTTKSPTYRNVCTGTTGHAEAVEILFDPQVISYEDLLKHFFRMHDPTSLNKQGGDVGTQYRSAIFYLSGTQKQQAETLMGRYAGAGKFTRPLVTTLEEARDFYPAEEYHQDYLTKNPGGYCHVSLHLASEPLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83662</accession>
    <name>Y656_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0656</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0656</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71297">
        <property type="entry name" value="A71297"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83662"/>
    <dbReference type="IntAct" id="O83662">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65639">
        <property type="protein sequence ID" value="AAC65639"/>
        <property type="gene ID" value="TP_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0656"/>
    <dbReference type="HOGENOM" id="CLU_3384332_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202295" description="Uncharacterized protein TP_0656">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="33" mass="3646" checksum="37964F03E2964260" modified="1998-11-01" version="1">MRTGTRCDLGELSHPRKTLPPRGMGILCNYTGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83663</accession>
    <name>CSRA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csrA</name>
        <name type="ordered locus">TP_0657</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71297">
        <property type="entry name" value="B71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882102.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83663"/>
    <dbReference type="SMR" id="O83663"/>
    <dbReference type="IntAct" id="O83663">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0657"/>
    <dbReference type="EnsemblBacteria" id="AAC65631">
        <property type="protein sequence ID" value="AAC65631"/>
        <property type="gene ID" value="TP_0657"/>
    </dbReference>
    <dbReference type="GeneID" id="57879180"/>
    <dbReference type="KEGG" id="tpa:TP_0657"/>
    <dbReference type="eggNOG" id="COG1551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164837_0_0_12"/>
    <dbReference type="OMA" id="IHRKEVY"/>
    <dbReference type="OrthoDB" id="2032250at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000177094" description="Translational regulator CsrA">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="73" mass="8336" checksum="45FA16B082FF25FF" modified="1998-11-01" version="1">MLILSRKTNQKIFIGDSIELTIIEIRGDQVKVGVEAPRSVKIFRQEVYEEIQRENRAASDSPWSPNSLPQLPV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83686</accession>
    <name>TSAD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">TP_0680</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71294">
        <property type="entry name" value="H71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882125.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83686"/>
    <dbReference type="SMR" id="O83686"/>
    <dbReference type="STRING" id="243276.TPANIC_0680"/>
    <dbReference type="EnsemblBacteria" id="AAC65643">
        <property type="protein sequence ID" value="AAC65643"/>
        <property type="gene ID" value="TP_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0680"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_12"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000096975" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="352" mass="38132" checksum="7597553A6AAD8C2F" modified="1998-11-01" version="1">MNVLGIETSCDETAVAIVKDGTHVCSNVVATQIPFHAPYRGIVPELASRKHIEWILPTVKEALARAQLTLADIDGIAVTHAPGLTGSLLVGLTFAKTLAWSMHLPFIAVNHLHAHFCAAHVEHDLAYPYVGLLASGGHALVCVVHDFDQVEALGATIDDAPGEAFDKVAAFYGFGYPGGKVIETLAEQGDARAARFPLPHFHGKGHRYDVSYSGLKTAVIHQLDHFWNKEYERTAQNIAAAFQACAINILLRPLARALQDTGLPTAVVCGGVAANSLLRKSVADWKHARCVFPSREYCTDNAVMVAALGYRYLIRGDRSFYGVTERSRIAHFSKRGGDRLAAQRSAASQPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83704</accession>
    <name>O83704_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71289">
        <property type="entry name" value="F71289"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882151.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83704">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0706"/>
    <dbReference type="EnsemblBacteria" id="AAC65674">
        <property type="protein sequence ID" value="AAC65674"/>
        <property type="gene ID" value="TP_0706"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75881">
        <property type="protein sequence ID" value="AGN75881"/>
        <property type="gene ID" value="TPANIC_0706"/>
    </dbReference>
    <dbReference type="GeneID" id="57879231"/>
    <dbReference type="KEGG" id="tpa:TP_0706"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.696"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_2_12"/>
    <dbReference type="OMA" id="YEFYFFD"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503440" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="308" mass="33622" checksum="6B6F716104D4ECE2" modified="1998-11-01" version="1">MVRAAVCSCLCVCVAHPAVCGPYPLIAQLQGQDALFRQYSDDVRAARVALAQGKRGNDLPLRFYAYRVKKADTIIRIAARCGIPYDAVASLNRIETLHTPLEGRTLLLPTVPGLYVSADPHLPLERLIYALIKKGQGPSFFLSLPGTAQTTHTREKREVVCAPQALFDGTVRAFFLKPFYRFPLASGRLTSGFGARKSPFTGRLSYHPGIDLAAPMGALVYACASGQVATIAYNRLYGKYVILQHTDGRHSLYGHLSAVRVRVQQKLSVGAVIGNVGSTGASTGPHLHFEVREAGVPQNPERFMEKFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83711</accession>
    <name>Y723_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0723</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0723</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71291">
        <property type="entry name" value="G71291"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83711"/>
    <dbReference type="IntAct" id="O83711">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65696">
        <property type="protein sequence ID" value="AAC65696"/>
        <property type="gene ID" value="TP_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0723"/>
    <dbReference type="HOGENOM" id="CLU_3241009_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202311" description="Uncharacterized protein TP_0723">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <sequence length="44" mass="5140" checksum="1D0ADD46A40A5F9B" modified="1998-11-01" version="1">MMVHFRFPFPGGEFPVSAQPEFELVARLHAAVVREEDVWQKRTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83733</accession>
    <name>Y752_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0752</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0752</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71284">
        <property type="entry name" value="C71284"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882197.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83733"/>
    <dbReference type="SMR" id="O83733"/>
    <dbReference type="IntAct" id="O83733">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0752"/>
    <dbReference type="EnsemblBacteria" id="AAC65729">
        <property type="protein sequence ID" value="AAC65729"/>
        <property type="gene ID" value="TP_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0752"/>
    <dbReference type="eggNOG" id="ENOG5032KME">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747921_0_0_12"/>
    <dbReference type="OMA" id="IVERAMH"/>
    <dbReference type="OrthoDB" id="1636936at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014258" description="Uncharacterized protein TP_0752">
        <location>
            <begin position="29"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR">
        <location>
            <begin position="307"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="380" mass="43043" checksum="D585DF63F0AC6BB7" modified="1998-11-01" version="1" precursor="true">MQFLSDTQRMVLSRAVCASFFFFHVAVAAYTARVQEMAMRGFALRNFQQVHAYFEQHIPLLSSFTEKKEALSLFAQYLELHDAHERAAHRYRDAALYALGTERVQFLLEATRNAMAADAREYARETLAEVEHIGVQVLNKKQHATFLVYHVWLALHAASTAAHLHEQLERLEEYGTQGVFNVFETVLLFTRWWITQDEKVAQRLTERYPQSFEALSVIGAVEIAPSVFWHLMPRAYGEAVESMGKSETVVLQDAKLRPVPEVVAAHRTRRAHVAADGTAARSAMSSSHNLGVSILEGGVSVPDEVGAGDEKPRGYQLGFFRAKENAQRLMDDLERRGFGFQLHTVRRADAVYYQVFVPEDDSGFVGHRLKDAGYETFPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83750</accession>
    <name>O83750_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71283">
        <property type="entry name" value="H71283"/>
    </dbReference>
    <dbReference type="IntAct" id="O83750">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0771"/>
    <dbReference type="EnsemblBacteria" id="AAC65739">
        <property type="protein sequence ID" value="AAC65739"/>
        <property type="gene ID" value="TP_0771"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75944">
        <property type="protein sequence ID" value="AGN75944"/>
        <property type="gene ID" value="TPANIC_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0771"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.758"/>
    <dbReference type="eggNOG" id="COG1283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025623_0_1_12"/>
    <dbReference type="OMA" id="FCAVAYN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="593" mass="65374" checksum="A7D57A08B090A0FE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83751</accession>
    <name>Y772_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0772</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0772</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71284">
        <property type="entry name" value="A71284"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882217.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83751"/>
    <dbReference type="IntAct" id="O83751">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0772"/>
    <dbReference type="PRIDE" id="O83751"/>
    <dbReference type="EnsemblBacteria" id="AAC65742">
        <property type="protein sequence ID" value="AAC65742"/>
        <property type="gene ID" value="TP_0772"/>
    </dbReference>
    <dbReference type="GeneID" id="57879293"/>
    <dbReference type="KEGG" id="tpa:TP_0772"/>
    <dbReference type="eggNOG" id="ENOG5031C89">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088597_0_0_12"/>
    <dbReference type="OMA" id="QLENGMA"/>
    <dbReference type="OrthoDB" id="1782246at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202320" description="Uncharacterized protein TP_0772">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="274" mass="30839" checksum="EE39DD5AAE5BA414" modified="1998-11-01" version="1">MCATLRPMETLGFCMLSPSTLPLRKWGIRLCRAGYRALGALLGTGVLVCCASSTNMTVSNDYPPKELGVLNAYTVDRLRTAISPRDFTFVFDPPIDTVLMQFKFLLDGITLYLERKDRTALREAIEKYLGEYEAQTLTREKSSERAYFGTTTPLMTWGILGSAHNATPTMRFEYQFITDDRPYFIIANRTIPGANGYNCPAVRIALSPAQCSQVMQYLDQGNLDALLEEMAQSFETFDTQQDPKKTPETDKNAAYKGKEKKGKKEERGPRSIMK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83759</accession>
    <name>NADE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="1">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nadE</name>
        <name type="ordered locus">TP_0780</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks the conserved active sites for the glutaminase activity.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71282">
        <property type="entry name" value="E71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882225.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0780"/>
    <dbReference type="EnsemblBacteria" id="AAC65748">
        <property type="protein sequence ID" value="AAC65748"/>
        <property type="gene ID" value="TP_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0780"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025662_0_0_12"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152246" description="Putative glutamine-dependent NAD(+) synthetase">
        <location>
            <begin position="1"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ligase" evidence="3">
        <location>
            <begin position="346"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="496"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P9WJJ3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="679" mass="72154" checksum="370BA934CC405878" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83763</accession>
    <name>Y784_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0784</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0784</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71283">
        <property type="entry name" value="A71283"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882229.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83763"/>
    <dbReference type="IntAct" id="O83763">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0784"/>
    <dbReference type="EnsemblBacteria" id="AAC65754">
        <property type="protein sequence ID" value="AAC65754"/>
        <property type="gene ID" value="TP_0784"/>
    </dbReference>
    <dbReference type="GeneID" id="57879305"/>
    <dbReference type="KEGG" id="tpa:TP_0784"/>
    <dbReference type="HOGENOM" id="CLU_114980_0_0_12"/>
    <dbReference type="OMA" id="EPSTREY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202324" description="Uncharacterized protein TP_0784">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <sequence length="199" mass="22512" checksum="D2728CDCE77144C4" modified="1998-11-01" version="1">MRIRLLFAPVSCLLLVCCADSSALRWIQQPSATRNTPTIAFFQVTFDRYNTHLLETRLHAQTLEFYHHDQTWTARDIHFTRYDGNGRASVRGHAGVLLTDCEGTVFYLGKKVDCFFPHEGLRLEGRAFRWENTRALFTSDHFSPVRISDASGAVVTGVGLCVNARTKRFVFQNGVHIDVDLDSFAKTRASRYAAPNLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83764</accession>
    <name>O83764_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OstA-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71283">
        <property type="entry name" value="B71283"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882230.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83764">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0785"/>
    <dbReference type="EnsemblBacteria" id="AAC65749">
        <property type="protein sequence ID" value="AAC65749"/>
        <property type="gene ID" value="TP_0785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75957">
        <property type="protein sequence ID" value="AGN75957"/>
        <property type="gene ID" value="TPANIC_0785"/>
    </dbReference>
    <dbReference type="GeneID" id="57879306"/>
    <dbReference type="KEGG" id="tpa:TP_0785"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.771"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080451_1_0_12"/>
    <dbReference type="OMA" id="YIEARGN"/>
    <dbReference type="OrthoDB" id="1368384at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OstA-like_N" evidence="1">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="228" mass="26085" checksum="E1E0BFF4C08C2AEB" modified="1998-11-01" version="1">MTRASSYPAFSPVPFLRTVLLALFLMSLCVWQRAHARGKVRFFADSLEGSADPHAPRTVLRGNARMYFADLEIHADKIEISGDDYHLVTATGNVRGEKKTQHLTFSAQSLHFSRNAHTTELLGAAQISDKRENVMARAERIVYHEKNETLLLQMNVSLTYQDLQCQAMFGMYYRKSIFLELSGAPRVSDRGNLFQAERITLNMARREIQLHGKVQGSILKPYEWEQHR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83768</accession>
    <name>Y789_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0789</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0789</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71280">
        <property type="entry name" value="D71280"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882234.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83768"/>
    <dbReference type="SMR" id="O83768"/>
    <dbReference type="IntAct" id="O83768">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0789"/>
    <dbReference type="EnsemblBacteria" id="AAC65764">
        <property type="protein sequence ID" value="AAC65764"/>
        <property type="gene ID" value="TP_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0789"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074356_0_0_12"/>
    <dbReference type="OMA" id="NKSGPFM"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014261" description="Uncharacterized protein TP_0789">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="258" mass="29040" checksum="5CE4E6C09FC240B1" modified="1998-11-01" version="1" precursor="true">MKRIAYVPLCAVVGGMCSMWAQSATDVMGSFKKTAETGTMGTQARMVVRKAGKTVSTLVLKQYTRYEKSGEQKTLIEFLSPLSVRGTRFLSLQKKDGAWEQYLYLPKLARVRSITGGDAHASFMGTDFSYHDLSLVGGVADLDECTLDGTESYGGKMCVRIQTLSHKPQARYVRALLWIEQETGRFVKGEFFDKKDKRVKIMTLSDYETIQGVDTPKTVVLETIAQRSTTTIHLTKVEYHMDIPEKVFTPEYLTQTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83794</accession>
    <name>O83794_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71275">
        <property type="entry name" value="H71275"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882266.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0822"/>
    <dbReference type="EnsemblBacteria" id="AAC65790">
        <property type="protein sequence ID" value="AAC65790"/>
        <property type="gene ID" value="TP_0822"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75992">
        <property type="protein sequence ID" value="AGN75992"/>
        <property type="gene ID" value="TPANIC_0822"/>
    </dbReference>
    <dbReference type="GeneID" id="57879339"/>
    <dbReference type="KEGG" id="tpa:TP_0822"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.808"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_12"/>
    <dbReference type="OMA" id="RIGFTVI"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="301" mass="33249" checksum="37BCD5E6DE950C7D" modified="1998-11-01" version="1">MVSRRAQAGNMRELEHFVQSLATAACALGAGLTQVATSERVWYLLRFVAVLCITSAFFRMLRRGVRRVVARRLSAQTQHFVFKTLNYLSFTVMTFTAFHWLGINVSALLGAAGIAGVALGFAAQTSVSNVISGLFVMTERAFRIQDVIEIDGIVGAVQSINLLSVALKTLDGQYVRVPNETILKANLVNYSHCPHRRVKTEVSVAYGSDLRRVQQLLLDVATRNRFVLSDPAPAVLWNAFADSGIDVTLLTWTHIEHFNDLRNAIFVDIDECFKQAGIEVPFPHVDVRVQGACDAPRAETV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83837</accession>
    <name>Y865_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0164 protein TP_0865</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0865</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0164 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71273">
        <property type="entry name" value="A71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882309.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83837"/>
    <dbReference type="STRING" id="243276.TPANIC_0865"/>
    <dbReference type="EnsemblBacteria" id="AAC65833">
        <property type="protein sequence ID" value="AAC65833"/>
        <property type="gene ID" value="TP_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0865"/>
    <dbReference type="eggNOG" id="ENOG5033RFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042920_0_0_12"/>
    <dbReference type="OMA" id="HRFLSAY"/>
    <dbReference type="OrthoDB" id="848913at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005362">
        <property type="entry name" value="UPF0164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03687">
        <property type="entry name" value="UPF0164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000036220" description="UPF0164 protein TP_0865">
        <location>
            <begin position="50"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="479" mass="52439" checksum="67592F18F1326955" modified="1998-11-01" version="1" precursor="true">MVRMRRRRACSSGGACGCAAVRGARSFLSVRVLGMRIGMSALCLAPLFARTASLGAWSSQGGEVLGEVRARVPAHRRVRRAVSGTSVTPVVAMAAKTSEKQKGVGRRALSLRTGGRYEMLGLAFTALADDASFFEANAAGSAAFPYLLVGGFHFARVNQSHTDTIALVHSIGRTGYGFSASVQYPYLTMEGKAVGGVAIFNVAHRFLSAYRFKGISVGTNVKVGYRDSSAGGERNKKNQGGKKHVVVTADIGLQGTWSVAKNFGSHEPNLWVGGTVKNVGLSVEVDASNSGSSMSGGRTVHATNSSFILACAYQPIRWFLFGTGIEWKYNVQEFADNNRFRYGVAFLLLPVQYVAFGSNVFLTGLASDIRASAGVEFKSTWVRVDLTYTYESDKDEHVISCGIAGFFNRDRRKHLEKEVYTSYLRGLRHYDAQHYEEAIAEWRRTLQRAGSFEPAREGIERATKLLQLNRQVYDFHFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83849</accession>
    <name>O83849_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC_transp_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71271">
        <property type="entry name" value="E71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882322.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0879"/>
    <dbReference type="EnsemblBacteria" id="AAC65841">
        <property type="protein sequence ID" value="AAC65841"/>
        <property type="gene ID" value="TP_0879"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76048">
        <property type="protein sequence ID" value="AGN76048"/>
        <property type="gene ID" value="TPANIC_0879"/>
    </dbReference>
    <dbReference type="GeneID" id="57879393"/>
    <dbReference type="KEGG" id="tpa:TP_0879"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.863"/>
    <dbReference type="eggNOG" id="COG3225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543946_0_0_12"/>
    <dbReference type="OMA" id="IANFADH"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="29"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="493" mass="56138" checksum="F4DEB2732CC82EEC" modified="1998-11-01" version="1">MSRKHHIPCTVMILNIMMSVFVTFCTPVRCDLTAQRAYSLSAHTIKLFESVESTVEITWFYSTDVDRYIPTVIYVRDLLKEYAHQLSKQCAVAMKDINLLSQSLRKELGFVARRVTYTRNTASIAYDAYSAILVEYRGMARAVPFVSDTKRLEYDIARLIIQMQQEMSADMMSRGIYVLAPPESLSTTYAHVLPRLQSEGLLPEILSISLPQLDTRIPLLILGSGYVDEHAVTLLDAFLQKGGNALCFVSGNSVQLNDQWTVEEKRHDFLINLLSTYGITINSDLILDEQSFAVSLPSVYETQYDRVSYPFWPVVTLKPYTHGVPVMVQAGIQFLRLFWPSSIRVSFPARVFESTSNHSLCMTAPFNIDPSVDHLKDLAKGKMPAPQAFVAFRDYPGKLMVVSDEYMVSAIVEHTHNGENLDFMINCIQWLCGNDGLLMLKSKNPAWLPLKSFRDEQKFARIVHRARYLNIVAIPVLIGMLFVVMQILYRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83864</accession>
    <name>O83864_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71266">
        <property type="entry name" value="C71266"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882337.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83864">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0894"/>
    <dbReference type="EnsemblBacteria" id="AAC65851">
        <property type="protein sequence ID" value="AAC65851"/>
        <property type="gene ID" value="TP_0894"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76063">
        <property type="protein sequence ID" value="AGN76063"/>
        <property type="gene ID" value="TPANIC_0894"/>
    </dbReference>
    <dbReference type="GeneID" id="57879408"/>
    <dbReference type="KEGG" id="tpa:TP_0894"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.879"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034061_0_0_12"/>
    <dbReference type="OMA" id="IDADNTQ"/>
    <dbReference type="OrthoDB" id="990092at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="340" mass="38411" checksum="522DF59AC896F10C" modified="1998-11-01" version="1">MEKKFALLIDGDNISPKFLEGIVGEVSKEGDIHVRRVYGDWTTPNMNGWKGLLTKIPIRPVQQFRYGDNATDNTIIMEAIELANNNRAINAVCIASTDSDYYSLALKLREYGLYVLGIGKRNAREIWVSACNEFKYIENIETEHFGLSAGFAFHTESDAAAVPGAGVDAVEEDTGGFDLGKLIAHAYRNSRMTEEGWVSLSNLGKSLRITKPEFDPRSYNHSTLREMVEALPELFEVQSDRRIPPNYWVRAVRGAHKRTVLYGVIKRFRERDRWGVISHEELGDFRFVYSNLKRECRATALPEGTTVSFSVFRMPNDQGKSDEERHGRAADVLVVKRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83865</accession>
    <name>O83865_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71266">
        <property type="entry name" value="D71266"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882338.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83865">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0895"/>
    <dbReference type="EnsemblBacteria" id="AAC65865">
        <property type="protein sequence ID" value="AAC65865"/>
        <property type="gene ID" value="TP_0895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76064">
        <property type="protein sequence ID" value="AGN76064"/>
        <property type="gene ID" value="TPANIC_0895"/>
    </dbReference>
    <dbReference type="GeneID" id="57879409"/>
    <dbReference type="KEGG" id="tpa:TP_0895"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.880"/>
    <dbReference type="eggNOG" id="COG3439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116237_2_0_12"/>
    <dbReference type="OMA" id="VIRHDEL"/>
    <dbReference type="OrthoDB" id="1819840at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697185" description="DUF302 domain-containing protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF302" evidence="2">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18863" checksum="9D4C52AD010AA33F" modified="1998-11-01" version="1">MCRRLCHHRWRVWGKVASLGVLLLGGLVACTSSAAGSTSNTRPGVRMTITSRYPFDRTMQLLESALRTQGFSVFGIVDYREAAHKQNLDIQPAKLMVVGFPKIGTPLMLEDPYFLLRVPLYLMVTDVRGKTRVSFHNTRGLMDSYVELSDMDQAIELVESIVKKTLAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83876</accession>
    <name>KHPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name type="ordered locus">TP_0906</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71267">
        <property type="entry name" value="G71267"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83876"/>
    <dbReference type="SMR" id="O83876"/>
    <dbReference type="IntAct" id="O83876">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0906"/>
    <dbReference type="EnsemblBacteria" id="AAC65858">
        <property type="protein sequence ID" value="AAC65858"/>
        <property type="gene ID" value="TP_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0906"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_12"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="KhpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000163238" description="RNA-binding protein KhpA">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <sequence length="80" mass="8686" checksum="9152D0A754C8E732" modified="1998-11-01" version="1">MVTMEEELIAYIARALVDRPGEVTVTKSPGEGLEILQLRVASEDVGKVIGKHGRIARALRTLLSASAHASQTRYALEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83881</accession>
    <name>O83881_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71268">
        <property type="entry name" value="D71268"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882354.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83881">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0911"/>
    <dbReference type="EnsemblBacteria" id="AAC65862">
        <property type="protein sequence ID" value="AAC65862"/>
        <property type="gene ID" value="TP_0911"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76079">
        <property type="protein sequence ID" value="AGN76079"/>
        <property type="gene ID" value="TPANIC_0911"/>
    </dbReference>
    <dbReference type="GeneID" id="57879421"/>
    <dbReference type="KEGG" id="tpa:TP_0911"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.894"/>
    <dbReference type="eggNOG" id="COG2257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_4_2_12"/>
    <dbReference type="OMA" id="PQLYAVI"/>
    <dbReference type="OrthoDB" id="1823885at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004683">
        <property type="entry name" value="T3SS_FlhB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00789">
        <property type="entry name" value="flhB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="83" mass="8996" checksum="756E63CE7CE3D1D9" modified="1998-11-01" version="1">MKRKRACSVALSYATGDKAPIIVASGTGAIAEKIVEIAKKFDIALVQDELLARVLSEHRIGACIPPETYQVVSAIFAFLYTQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83883</accession>
    <name>Y913_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0102 protein TP_0913</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0913</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71268">
        <property type="entry name" value="F71268"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882356.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83883"/>
    <dbReference type="SMR" id="O83883"/>
    <dbReference type="IntAct" id="O83883">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0913"/>
    <dbReference type="EnsemblBacteria" id="AAC65864">
        <property type="protein sequence ID" value="AAC65864"/>
        <property type="gene ID" value="TP_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0913"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_1_12"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167385" description="UPF0102 protein TP_0913">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="126" mass="14586" checksum="C9345F99ADAEDFC5" modified="1998-11-01" version="1">MPKHNKLLGAFGEAYAARWLATRGYIIITRNWRRATGEIDIIAQQDDTIVFVEVKTLRCTSYADLAIIVGKRKQKRICETAKHFLASAREYNHMCARFDVIVLRSDPFRRQDVDIVHLPHAFEDLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83886</accession>
    <name>Y916_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0916</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0916</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71265">
        <property type="entry name" value="A71265"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83886"/>
    <dbReference type="SMR" id="O83886"/>
    <dbReference type="IntAct" id="O83886">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65877">
        <property type="protein sequence ID" value="AAC65877"/>
        <property type="gene ID" value="TP_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0916"/>
    <dbReference type="HOGENOM" id="CLU_3259314_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202350" description="Uncharacterized protein TP_0916">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <sequence length="42" mass="4801" checksum="930F308E9B3C587F" modified="1998-11-01" version="1">MAPGLWEQEQSLSCGTCTYGRTEVNSRILRKLRVGIGYEREL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83918</accession>
    <name>O83918_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly(ethylene terephthalate) hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.101</ecNumber>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12420"/>
            <dbReference type="Rhea" id="RHEA-COMP:12421"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:131701"/>
            <dbReference type="ChEBI" id="CHEBI:131704"/>
            <dbReference type="EC" id="3.1.1.101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:49529"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47348"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:50477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:47349"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.101" evidence="5"/>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71261">
        <property type="entry name" value="F71261"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882396.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0952"/>
    <dbReference type="ESTHER" id="trepa-TP0952">
        <property type="family name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65907">
        <property type="protein sequence ID" value="AAC65907"/>
        <property type="gene ID" value="TP_0952"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76117">
        <property type="protein sequence ID" value="AGN76117"/>
        <property type="gene ID" value="TPANIC_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0952"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.1005"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070820_0_0_12"/>
    <dbReference type="OMA" id="RGWNSTQ"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="Chlorophyllase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="Chlorophyllase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697299" description="Poly(ethylene terephthalate) hydrolase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="345" mass="39681" checksum="FD59315635D6664B" modified="1998-11-01" version="1">MLCLFLCGCVMKKWCGLAFSIFFSFFLRAQDLTFQEVFEVAACNDDVSLLNKMHKRTVRDNQFDEQLTDRVHLRYPASVYYPAHQGTYPLIMLSRGWNSTQDYQRALARFLAAQGFVTVVFTSRAQRRPPDFLSTFDSVYALMQRVNEQEGSPLYRKVDFTRVGVLGHSMGGTAALHYANRYPERIRTVVALHPFNGGADMVNMVGGKNEQLGTDLRSVRAAVLILTGTKDMLAYPERSYEFFQSLPQDVPACFLSLKGMGHGAGTDKYFEVWGFTYNKTLSVESFALYRRLISAWFRLFLREEEEYRALFNEHGRPFRNLKPHLSQETGRAHSYPFFCEQNISN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83935</accession>
    <name>Y969_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0969</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0969</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TP096X family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71260">
        <property type="entry name" value="D71260"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83935"/>
    <dbReference type="IntAct" id="O83935">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0969"/>
    <dbReference type="EnsemblBacteria" id="AAC65927">
        <property type="protein sequence ID" value="AAC65927"/>
        <property type="gene ID" value="TP_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0969"/>
    <dbReference type="eggNOG" id="ENOG5032M6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532003_0_0_12"/>
    <dbReference type="OMA" id="MGEPAIT"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014269" description="Uncharacterized protein TP_0969">
        <location>
            <begin position="16"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="539" mass="59651" checksum="626A657AB3E5A37E" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83946</accession>
    <name>O83946_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensory transduction histidine kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71258">
        <property type="entry name" value="C71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882425.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83946">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0981"/>
    <dbReference type="EnsemblBacteria" id="AAC65936">
        <property type="protein sequence ID" value="AAC65936"/>
        <property type="gene ID" value="TP_0981"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76145">
        <property type="protein sequence ID" value="AGN76145"/>
        <property type="gene ID" value="TPANIC_0981"/>
    </dbReference>
    <dbReference type="GeneID" id="57879490"/>
    <dbReference type="KEGG" id="tpa:TP_0981"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.966"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_12"/>
    <dbReference type="OMA" id="TTDMMTK"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="247"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="387" mass="43331" checksum="5E4ABF57C3C1549A" modified="1998-11-01" version="1">MSYRTRSSLDRKRDYICPACNLYKAGSCARIVHPRWQGILVKECVSKEKRIYDLKQLLEISKSLNSLLEFTHLVEAILYVAMAQTKTLGAALFTKKNAGMKKLSLSRNVCGFDVSHHAQLIISEEDPILRLLDEKACCLSPEEVQSALAPSKSVRSLLDLQPSLFVPLRAKDHLVGLILLGKKINVHEAYTPYDQSIIMDIAQLAAIAINNALLLEQATTDMMTQMKLKHYFFAMLTAKLDTLSTQETVSVLMLDIDFFKQINDTHGHLCGDLVLQHVAEIIRSCTRPCDIASRYGGEEFMLMLSNNSSREAAHVAERIRVATEQLTIPYHEVSIRVTVSAGVAEYLPNQESAETLIKRADSALYQAKQNGRNKVVISEKNMCSSQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83949</accession>
    <name>HTPG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">TP_0984</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71258">
        <property type="entry name" value="F71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882428.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83949"/>
    <dbReference type="SMR" id="O83949"/>
    <dbReference type="IntAct" id="O83949">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0984"/>
    <dbReference type="EnsemblBacteria" id="AAC65938">
        <property type="protein sequence ID" value="AAC65938"/>
        <property type="gene ID" value="TP_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0984"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_12"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000063018" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="349"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="566"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="639" mass="72938" checksum="3E8FDBAC2282C31D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83952</accession>
    <name>Y987_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0987</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0987</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71256">
        <property type="entry name" value="C71256"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83952"/>
    <dbReference type="IntAct" id="O83952">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65950">
        <property type="protein sequence ID" value="AAC65950"/>
        <property type="gene ID" value="TP_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0987"/>
    <dbReference type="HOGENOM" id="CLU_3012965_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202369" description="Uncharacterized protein TP_0987">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <sequence length="56" mass="6479" checksum="268C6FA075DB7619" modified="1998-11-01" version="1">MSYDFTQYQRPSGRLLARKDFLHVVAVRDAPHDGKYAVEVPVHVTRTCLILLPRKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83958</accession>
    <name>RLPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="1">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlpA</name>
        <name type="ordered locus">TP_0993</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71257">
        <property type="entry name" value="A71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882437.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83958"/>
    <dbReference type="SMR" id="O83958"/>
    <dbReference type="IntAct" id="O83958">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0993"/>
    <dbReference type="EnsemblBacteria" id="AAC65949">
        <property type="protein sequence ID" value="AAC65949"/>
        <property type="gene ID" value="TP_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0993"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_3_3_12"/>
    <dbReference type="OMA" id="PANEDRK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000030810" description="Probable endolytic peptidoglycan transglycosylase RlpA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="318" mass="33376" checksum="1597E8B85CC019F8" modified="1998-11-01" version="1" precursor="true">MMDKRVVAVAAVLWNVQMLFAAGEVIVPEGYASYYAESFNGRPTASGEIFDMNAYTAAHRTLPFGTVVELTNLDNGKKVIVRINDRGPYAANREIDVSKAAAVALDMLNAGVARVSIHKADPNAHASQQRNDRQTSPGVLPQDSFGVPPTAPTSSAPVMYADPHNPPPAPVGRRAGTPGVPGVANTTDVPASEYGAPPVAYAAPGSTPSRVPYGTAVPGSAAPNSHAQPVPSSSSYAAAAPLPYAAGGGKVSGMKSVYTPTHSGETRGVLWRIQLGAFVREENALRLVVKCARRALILHMSEQSTRCAWCCRGYAPRT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83980</accession>
    <name>SYA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Alanine--tRNA ligase</fullName>
            <ecNumber>6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alanyl-tRNA synthetase</fullName>
            <shortName>AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">alaS</name>
        <name type="ordered locus">TP_1017</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two domains; the N-terminal catalytic domain (in this organism this is shorter than usual) and the editing domain; the C-terminal C-Ala domain found in most orthologs is missing. The editing domain removes incorrectly charged amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71253">
        <property type="entry name" value="E71253"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882461.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83980"/>
    <dbReference type="SMR" id="O83980"/>
    <dbReference type="IntAct" id="O83980">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1017"/>
    <dbReference type="EnsemblBacteria" id="AAC65968">
        <property type="protein sequence ID" value="AAC65968"/>
        <property type="gene ID" value="TP_1017"/>
    </dbReference>
    <dbReference type="GeneID" id="57879528"/>
    <dbReference type="KEGG" id="tpa:TP_1017"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_0_2_12"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000075237" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="605" mass="67187" checksum="9EB42BC1C86DF4C4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83992</accession>
    <name>Y1029_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1029</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1029</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71251">
        <property type="entry name" value="H71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882473.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83992"/>
    <dbReference type="SMR" id="O83992"/>
    <dbReference type="STRING" id="243276.TPANIC_1029"/>
    <dbReference type="EnsemblBacteria" id="AAC65982">
        <property type="protein sequence ID" value="AAC65982"/>
        <property type="gene ID" value="TP_1029"/>
    </dbReference>
    <dbReference type="GeneID" id="57879541"/>
    <dbReference type="KEGG" id="tpa:TP_1029"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090659_0_0_12"/>
    <dbReference type="OMA" id="IRIHDKY"/>
    <dbReference type="OrthoDB" id="1837600at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202374" description="Uncharacterized protein TP_1029">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="228" mass="25187" checksum="39EB5D6EEAE1846A" modified="1998-11-01" version="1">MSKISSKISSVDQEKFQAFLQQILRNVKTQEDPRVLDAYRRLFRKSVPFSMRSYVAAHLAHTHCRAGATAGSTRRTGAREGIRTGSAHAPSCASAPASAARARDFERKARDYPALCPGDTTSIFISIGKNRHIYPRDIIALLMQRADVAREHIGTIRILDHYSFIQVLSGEAEAVIARLNGLFYRGRTLTVSHSRRADEHPAPSTEPHAAAVAPEPDFMAEPIPALEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1995-11-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>P45685</accession>
    <name>TPL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Protein tpl</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tpl</name>
        <name type="ordered locus">TP_0046</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1994-07" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning of signal peptidase II-like activity from Treponema pallidum subspecies pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Jones T.S."/>
                <person name="Vega R.B."/>
                <person name="Tryon V.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Supposed to have signal peptidase II-like activity.</text>
    </comment>
    <dbReference type="EMBL" id="U11881">
        <property type="protein sequence ID" value="AAA20395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71371">
        <property type="entry name" value="H71371"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881495.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P45685"/>
    <dbReference type="SMR" id="P45685"/>
    <dbReference type="IntAct" id="P45685">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0046"/>
    <dbReference type="PRIDE" id="P45685"/>
    <dbReference type="EnsemblBacteria" id="AAC65042">
        <property type="protein sequence ID" value="AAC65042"/>
        <property type="gene ID" value="TP_0046"/>
    </dbReference>
    <dbReference type="GeneID" id="57878587"/>
    <dbReference type="KEGG" id="tpa:TP_0046"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_5_12"/>
    <dbReference type="OMA" id="CCHAVSD"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072649" description="Protein tpl">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00744"/>
        </source>
    </evidence>
    <sequence length="233" mass="26872" checksum="B672F2471B3E0DA1" modified="1995-11-01" version="1">MIPKLSPNADPCTACASTPAFPPQPMEEEGEFLYQLRLEYSREVLYARFHAALRVHTFVVVPTRYGNDIARCVGRIRTPVQTDIASVVRVASDQDLCTWHIHREKERAAEMIFRDRIEHYQLEMKCICCHYPLEEARVVFLYSAPARVDFRELVRDLGATFGTRVELRQINEREEARIVGGIDCCGRALCCCSVFSRLRPVSVKMVKEKNLLFRSTQMMGRCGRLRCCLTFEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>P74930</accession>
    <name>FLIP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliP</name>
        <name type="ordered locus">TP_0718</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Gene" volume="166" first="57" last="64">
            <title>Identification and sequences of the Treponema pallidum fliM', fliY, fliP, fliQ, fliR and flhB' genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="8529894"/>
            <dbReference type="DOI" id="10.1016/0378-1119(95)00583-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4507">
        <property type="entry name" value="JC4507"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882163.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74930"/>
    <dbReference type="SMR" id="P74930"/>
    <dbReference type="STRING" id="243276.TPANIC_0718"/>
    <dbReference type="EnsemblBacteria" id="AAC65684">
        <property type="protein sequence ID" value="AAC65684"/>
        <property type="gene ID" value="TP_0718"/>
    </dbReference>
    <dbReference type="GeneID" id="57879243"/>
    <dbReference type="KEGG" id="tpa:TP_0718"/>
    <dbReference type="eggNOG" id="COG1338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042028_1_0_12"/>
    <dbReference type="OMA" id="MPPNQIL"/>
    <dbReference type="OrthoDB" id="1049349at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000191990" description="Flagellar biosynthetic protein FliP">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="271" mass="30734" checksum="BBE0138E80C90EF7" modified="1997-02-01" version="1">MIRARACVRRALFFVSLFFFPLFAQDARGGVERGVTGINAERPASRIPFINFDIREPQTNREVAFSVQLLLLLTLISLAPSILLLMTAFLRLSIVLDFIKRALSLQQVPPTQVLHGIALFLALFIMWPVFTEIYAKSFKPLTDGQVDIQTAYTEAERPLRVFMYRQMAHDPSSVRLCMSMAKLPKPDTLADVPTYVLIPAFILHELTVAFQIGIFLYLPFIIVDMVVASILMSMGMIMLPPVQISLPFKLVLFVLVDGWNLLIDRLFHSFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="146" xmlns="http://uniprot.org/uniprot">
    <accession>P74933</accession>
    <accession>O83143</accession>
    <name>DPO1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase I</fullName>
            <shortName>POL I</shortName>
            <ecNumber>2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">polA</name>
        <name type="ordered locus">TP_0105</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="J. Med. Microbiol." volume="49" first="657" last="667">
            <title>Molecular cloning of a gene (polA) coding for an unusual DNA polymerase I from Treponema pallidum.</title>
            <authorList>
                <person name="Rodes B."/>
                <person name="Liu H."/>
                <person name="Johnson S."/>
                <person name="George R."/>
                <person name="Steiner B.M."/>
            </authorList>
            <dbReference type="PubMed" id="10882092"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7"/>
    <dbReference type="EMBL" id="U57757">
        <property type="protein sequence ID" value="AAB17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71365">
        <property type="entry name" value="F71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881554.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74933"/>
    <dbReference type="SMR" id="P74933"/>
    <dbReference type="STRING" id="243276.TPANIC_0105"/>
    <dbReference type="EnsemblBacteria" id="AAC26553">
        <property type="protein sequence ID" value="AAC26553"/>
        <property type="gene ID" value="TP_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0105"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_12"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
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        <property type="entry name" value="SSF88723"/>
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        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000101261" description="DNA polymerase I">
        <location>
            <begin position="1"/>
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    <feature type="domain" description="5'-3' exonuclease" evidence="2">
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        <location>
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            <end position="589"/>
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    <feature type="sequence conflict" description="In Ref. 1; AAB17467." evidence="3" ref="1">
        <original>V</original>
        <variation>A</variation>
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            <position position="782"/>
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    <evidence type="ECO:0000250" key="1"/>
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    <sequence length="997" mass="112217" checksum="764DE97E4CCD2054" modified="1998-12-15" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>P96116</accession>
    <accession>Q56329</accession>
    <name>TROA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Periplasmic zinc-binding protein TroA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Tromp-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">troA</name>
        <name type="synonym">troMP1</name>
        <name type="ordered locus">TP_0163</name>
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    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="J. Bacteriol." volume="177" first="3556" last="3562">
            <title>Porin activity and sequence analysis of a 31-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp1).</title>
            <authorList>
                <person name="Blanco D.R."/>
                <person name="Champion C.I."/>
                <person name="Exner M.M."/>
                <person name="Erdjument-Bromage H."/>
                <person name="Hancock R.E."/>
                <person name="Tempst P."/>
                <person name="Miller J.N."/>
                <person name="Lovett M.A."/>
            </authorList>
            <dbReference type="PubMed" id="7768866"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1999" name="J. Bacteriol." volume="181" first="4420" last="4423">
            <title>Physicochemical evidence that Treponema pallidum TroA is a zinc-containing metalloprotein that lacks porin-like structure.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Lee Y.-H."/>
                <person name="Hagman K.E."/>
                <person name="Shevchenko D."/>
                <person name="Lingwood C.A."/>
                <person name="Hasemann C.A."/>
                <person name="Norgard M.V."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="10400603"/>
        </citation>
        <scope>CHARACTERIZATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Nat. Struct. Biol." volume="6" first="628" last="633">
            <title>Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone.</title>
            <authorList>
                <person name="Lee Y.-H."/>
                <person name="Deka R.K."/>
                <person name="Norgard M.V."/>
                <person name="Radolf J.D."/>
                <person name="Hasemann C.A."/>
            </authorList>
            <dbReference type="PubMed" id="10404217"/>
            <dbReference type="DOI" id="10.1038/10677"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 23-313</scope>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane.</text>
    </comment>
    <comment type="subunit">
        <text>Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be an outer membrane protein with porin-like properties.</text>
    </comment>
    <comment type="sequence caution" evidence="1">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAA92353" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="U16363">
        <property type="protein sequence ID" value="AAA92353.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71360">
        <property type="entry name" value="A71360"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881610.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
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    <dbReference type="PDB" id="1K0F">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A=32-308"/>
    </dbReference>
    <dbReference type="PDB" id="1TOA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B=23-308"/>
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    <dbReference type="STRING" id="243276.TPANIC_0163"/>
    <dbReference type="TCDB" id="3.A.1.15.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65151">
        <property type="protein sequence ID" value="AAC65151"/>
        <property type="gene ID" value="TP_0163"/>
    </dbReference>
    <dbReference type="GeneID" id="57878705"/>
    <dbReference type="KEGG" id="tpa:TP_0163"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_12"/>
    <dbReference type="OMA" id="DPHIWFD"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
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    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
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    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000031872" description="Periplasmic zinc-binding protein TroA">
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            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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    </evidence>
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            <dbReference type="PDB" id="1K0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="1TOA"/>
        </source>
    </evidence>
    <sequence length="308" mass="33570" checksum="2FDD8FF20D012B08" modified="1997-05-01" version="1" precursor="true">MIRERICACVLALGMLTGFTHAFGSKDAAADGKPLVVTTIGMIADAVKNIAQGDVHLKGLMGPGVDPHLYTATAGDVEWLGNADLILYNGLHLETKMGEVFSKLRGSRLVVAVSETIPVSQRLSLEEAEFDPHVWFDVKLWSYSVKAVYESLCKLLPGKTREFTQRYQAYQQQLDKLDAYVRRKAQSLPAERRVLVTAHDAFGYFSRAYGFEVKGLQGVSTASEASAHDMQELAAFIAQRKLPAIFIESSIPHKNVEALRDAVQARGHVVQIGGELFSDAMGDAGTSEGTYVGMVTHNIDTIVAALAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>P96117</accession>
    <name>TROB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Zinc transport system ATP-binding protein TroB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">troB</name>
        <name type="ordered locus">TP_0164</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TroABCD for zinc.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71357">
        <property type="entry name" value="A71357"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881611.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96117"/>
    <dbReference type="SMR" id="P96117"/>
    <dbReference type="IntAct" id="P96117">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0164"/>
    <dbReference type="TCDB" id="3.A.1.15.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="PRIDE" id="P96117"/>
    <dbReference type="EnsemblBacteria" id="AAC65154">
        <property type="protein sequence ID" value="AAC65154"/>
        <property type="gene ID" value="TP_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0164"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="SVWDVVM"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="chain" id="PRO_0000093025" description="Zinc transport system ATP-binding protein TroB">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="11"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="266" mass="29360" checksum="A7EB2DEDC4CF85B6" modified="1997-05-01" version="1">MAEISATAYAVQVDDLTLAYRQKPVLWDVDVRIPEGVIEAIIGPNGAGKSTLLKAIMGLLPLASGEVRVFGRPFSKERRRVAYVPQRSAVDWDFPTTVFDVVLMGSYGSLGWILRPGKREKARAREAIEEVGMGAFLDRQISELSGGQQQRVFLARALVQDADLYFMDEPFQGVDAATEQAIVTLLKTLKGRGKTLLVVHHDLQTVAEYFDRVLLLNVRVIAEGAVVSAFTEEYVQRAYGGRISSTLFPRGNKEDVHDARAHASVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>P96119</accession>
    <accession>O83198</accession>
    <name>TROD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Zinc transport system membrane protein TroD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">troD</name>
        <name type="ordered locus">TP_0166</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TroABCD for zinc.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71357">
        <property type="entry name" value="C71357"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342310.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96119"/>
    <dbReference type="SMR" id="P96119"/>
    <dbReference type="STRING" id="243276.TPANIC_0166"/>
    <dbReference type="TCDB" id="3.A.1.15.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65156">
        <property type="protein sequence ID" value="AAC65156"/>
        <property type="gene ID" value="TP_0166"/>
    </dbReference>
    <dbReference type="GeneID" id="57878708"/>
    <dbReference type="KEGG" id="tpa:TP_0166"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_1_12"/>
    <dbReference type="OMA" id="ALMGDGI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="chain" id="PRO_0000171155" description="Zinc transport system membrane protein TroD">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="367" mass="38764" checksum="991A23737DD6B900" modified="1997-05-01" version="1">MTMEVVLIAVVVSVACALCGVFLVLRRISLMSDAISHSVILGIVLGYFLSRTLSSFVPFVGAVIAGICSVICAELLQKTGMVKSDAAVGLVFPAMFGLGVILVSLYAGNVHLDTDAVLLGEIGLAPLDRVSFFAWSLPRSLVQMGSVLCGLLLLLALFFKELKISTFDPVLATSLGFSPTLINYGLMLAVSITCVGAFDSVGAVLVIALMITPPAAALLLTDNLLLMLVLASLLASCASISGLFLAVKIDGSIAGAMATMAGVLFALVYLFSPKHGVVRRCLVMRALKLDLDVVTLAVHLATHRYTVERSVECAEVHLTEHVSWSARRAARVVRTALRRGMVERHGALLLLTAQGVSLAQARLDVSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>P96121</accession>
    <name>GPMA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-dependent PGAM</shortName>
            <shortName evidence="1">PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">dPGM</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name type="synonym">gpm</name>
        <name type="synonym">pgm</name>
        <name type="ordered locus">TP_0168</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71357">
        <property type="entry name" value="E71357"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881615.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96121"/>
    <dbReference type="SMR" id="P96121"/>
    <dbReference type="IntAct" id="P96121">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0168"/>
    <dbReference type="EnsemblBacteria" id="AAC65158">
        <property type="protein sequence ID" value="AAC65158"/>
        <property type="gene ID" value="TP_0168"/>
    </dbReference>
    <dbReference type="GeneID" id="57878710"/>
    <dbReference type="KEGG" id="tpa:TP_0168"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_12"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179934" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="251" mass="28358" checksum="8589EE625A80D60B" modified="1997-05-01" version="1">MKLVLIRHGESEWNRLNLFTGWTDVPLTPRGESEAQEGGRVLQEAGFDFDLCYTSFLKRAIRTLNFVLQALDREWLPVHKSWKLNERHYGDLQGLNKTETAQKYGEQQVRVWRRSFDVAPPPLTVGDARCPHTQASYRGVCASGRTPVLPFTESLKDTVARVVPYFEEEIKPQMISGQRVLIVAHGNSLRALMKHIESLDETQIMEVNLPTGVPLVYEFEADFTLCGKRFLGNEADVAARAQAVADQGKSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>P96126</accession>
    <name>CHEY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chemotaxis protein CheY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cheY</name>
        <name type="ordered locus">TP_0366</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="7" first="267" last="284">
            <title>Identification, sequences, and expression of Treponema pallidum chemotaxis genes.</title>
            <authorList>
                <person name="Greene S.R."/>
                <person name="Stamm L.V."/>
                <person name="Hardham J.M."/>
                <person name="Young N.R."/>
                <person name="Frye J.G."/>
            </authorList>
            <dbReference type="PubMed" id="9255518"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA.</text>
    </comment>
    <dbReference type="EMBL" id="U61851">
        <property type="protein sequence ID" value="AAC45558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71335">
        <property type="entry name" value="D71335"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881814.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96126"/>
    <dbReference type="SMR" id="P96126"/>
    <dbReference type="STRING" id="243276.TPANIC_0366"/>
    <dbReference type="EnsemblBacteria" id="AAC65351">
        <property type="protein sequence ID" value="AAC65351"/>
        <property type="gene ID" value="TP_0366"/>
    </dbReference>
    <dbReference type="GeneID" id="57878894"/>
    <dbReference type="KEGG" id="tpa:TP_0366"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_12"/>
    <dbReference type="OMA" id="VMCTSVE"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0283">Flagellar rotation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0902">Two-component regulatory system</keyword>
    <feature type="chain" id="PRO_0000081056" description="Chemotaxis protein CheY">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <sequence length="144" mass="15736" checksum="439BA06C877692AF" modified="1997-05-01" version="1">MISKQDFPTINDRVPAGQKPNGAPYRVLVVDDSMFVSKQIGQILTSEGYEVADTAVDGVDGVEKYKAMSPGVDLVTMDITMPKMDGITALEKILEFDKNAKVVIISALGKEELVKKALLLGAKNYIVKPLDRKKVLERIASVLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-02-21" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q01305</accession>
    <name>TP75_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Protein Tp75</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">Tp75</name>
        <name type="ordered locus">TP_0006</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1991" name="Mol. Microbiol." volume="5" first="2405" last="2415">
            <title>Identification of Treponema pallidum subspecies pallidum genes encoding signal peptides and membrane-spanning sequences using a novel alkaline phosphatase expression vector.</title>
            <authorList>
                <person name="Blanco D."/>
                <person name="Giladi M."/>
                <person name="Champion C.I."/>
                <person name="Haake D.A."/>
                <person name="Chikami G.K."/>
                <person name="Miller J.N."/>
                <person name="Lovett M.A."/>
            </authorList>
            <dbReference type="PubMed" id="1791755"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1991.tb02086.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="X61226">
        <property type="protein sequence ID" value="CAA43538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71378">
        <property type="entry name" value="E71378"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q01305"/>
    <dbReference type="IntAct" id="Q01305">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0006"/>
    <dbReference type="EnsemblBacteria" id="AAC65002">
        <property type="protein sequence ID" value="AAC65002"/>
        <property type="gene ID" value="TP_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0006"/>
    <dbReference type="HOGENOM" id="CLU_3031119_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000022572" description="Protein Tp75">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="55" mass="5851" checksum="3802E0C7B1856E49" modified="1999-05-01" version="2" precursor="true">MGTRVRFSFCGIAGVCLLALGFLVSCSLQSSRSATKKSEARRTSYRIGLMTSTGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>Q56346</accession>
    <name>ALR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine racemase</fullName>
            <ecNumber evidence="1">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">alr</name>
        <name type="ordered locus">TP_0681</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1996-05" db="EMBL/GenBank/DDBJ databases">
            <title>Partial sequence of alanine racemase from Treponema pallidum.</title>
            <authorList>
                <person name="Steiner B.M."/>
                <person name="Rodes B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-198</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alanine racemase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAB17466" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65644" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65644.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U57756">
        <property type="protein sequence ID" value="AAB17466.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71295">
        <property type="entry name" value="A71295"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012460586.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56346"/>
    <dbReference type="SMR" id="Q56346"/>
    <dbReference type="IntAct" id="Q56346">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0681"/>
    <dbReference type="EnsemblBacteria" id="AAC65644">
        <property type="protein sequence ID" value="AAC65644"/>
        <property type="gene ID" value="TP_0681"/>
    </dbReference>
    <dbReference type="GeneID" id="57879206"/>
    <dbReference type="KEGG" id="tpa:TP_0681"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_12"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114590" description="Alanine racemase">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="377" mass="40312" checksum="96387BFF1EAD0913" modified="2002-03-05" version="3">MACNQALIHLANLRHNLGEIMSRTRARVCLPVKADAYGHGACDVAQAALSCGVHSFAVACVQEASQLRAAGVRAPILCLSTPTAEEISSLIEHRVHTVISERAHIALIARALRQSADTGATCGVHVKIDTGMGRIGCAPDEACALVQMVCATPGLHLEGVCTHFSVADSVRAEDLQYTEMQRAHFMHCVQYIRKSGISIPLVHAANSAALLCHPRAHFDMVRPGLLAYGYAPESVHPAVRSVFLPVMELVTQVRAIKKIPAGAYVSYQRLWRAHTETHVGILPIGYADGVMRALSPGLQVCIGGKWYPVVGAICMDQCVVDLGTPLRVTVGDRVTLFGPQDAGGPGQGADVLASHAGTIPYELLCAIGKRVERVYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7ITI9</accession>
    <name>F7ITI9_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71279">
        <property type="entry name" value="A71279"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882264.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0820"/>
    <dbReference type="EnsemblBacteria" id="AAC65783">
        <property type="protein sequence ID" value="AAC65783"/>
        <property type="gene ID" value="TP_0820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75990">
        <property type="protein sequence ID" value="AGN75990"/>
        <property type="gene ID" value="TPANIC_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0820"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.806"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094983_0_0_12"/>
    <dbReference type="OMA" id="WWYRLGS"/>
    <dbReference type="OrthoDB" id="1438690at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="256" mass="28834" checksum="3E3AF8DC839D9EF4" modified="2011-07-27" version="1">MSRVRVAFHKGRALCAGAFDVSEGGAVFTRTRTVAGAFVLVWFLARGSAQEQPPAAAQAGAAEVREALSLYRNGRSMDTSGGREDAQKMYTQAVELCRSVLERDPRHADAYAVCTWSLFRLGRYADTVALCQEALKISVDHRVVETLAEALFFVGDYKGSMHAMERYIDMAPRGERISVAYFYLGEIFRLTKRFRKADIAYSTAVNFEPSNALWWYRLGLAREYAGDKGFALDAYRRALHLRPEYKEAQESIRRLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83063</accession>
    <name>GREA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">greA</name>
        <name type="ordered locus">TP_0019</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71375">
        <property type="entry name" value="G71375"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83063"/>
    <dbReference type="SMR" id="O83063"/>
    <dbReference type="IntAct" id="O83063">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65015">
        <property type="protein sequence ID" value="AAC65015"/>
        <property type="gene ID" value="TP_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0019"/>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_12"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000176987" description="Transcription elongation factor GreA">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <sequence length="162" mass="18046" checksum="3AE7677F297751DA" modified="1998-11-01" version="1">MVSGRGLVVTAKMLNAKKKELQDLLDVRIPENSREIGRALELGDLRENAEYKAAREEQTRLNNMVTRLQEEIERAQVFDPTTVVAGRVSFGTVISLKNHTSGEDETYTILGPWESAPERGIISYMSPLGSNLLNRKTGEQLAFTVGEHEKVYEILSISAAEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83074</accession>
    <name>Y031_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0031</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0031</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71375">
        <property type="entry name" value="A71375"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881480.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83074"/>
    <dbReference type="IntAct" id="O83074">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0031"/>
    <dbReference type="EnsemblBacteria" id="AAC65032">
        <property type="protein sequence ID" value="AAC65032"/>
        <property type="gene ID" value="TP_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0031"/>
    <dbReference type="HOGENOM" id="CLU_2412291_0_0_12"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202179" description="Uncharacterized protein TP_0031">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="92" mass="10276" checksum="4EB638881276C4E8" modified="1998-11-01" version="1">MDLGQRVVRVIPLAPLPVRVYNAGGLRVDFFPRFFGRSPQGVGVGFARLKLSASVGSNGFRLTRAVWIFWLCFLVSGLSRAFLVYFLSVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83093</accession>
    <name>O83093_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SpoU_sub_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71372">
        <property type="entry name" value="H71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881503.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83093">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0054"/>
    <dbReference type="EnsemblBacteria" id="AAC65050">
        <property type="protein sequence ID" value="AAC65050"/>
        <property type="gene ID" value="TP_0054"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75274">
        <property type="protein sequence ID" value="AGN75274"/>
        <property type="gene ID" value="TPANIC_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0054"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.50"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_2_0_12"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="319" mass="35537" checksum="7F6021DA46B9B950" modified="1998-11-01" version="1">MLEHMKREQARSQLSHEPPKRRRASLTVCGLRAVETLGSIHPEKIHRFFFTPVRAKRFGPLCAYLAARKRLYRSANTQELERLTQSVHHQGVAATIDEPRFPAVTHSQVEFWVQRREFVVLLDRVGDAHNLGAIIRSAAFFGVHSLVVSDCRQQAQVTSATYRVAQGGMEFVQLLRCTNAQEVLEMCAGKMTRVGASPHAFRSLTRLSNILSPEEAVILVLGNEETGLSEHLTAHCDHLCRIAGSGQVESLNVAQAGALFLSTIVQLRQSPQDYTQGHRATPRAQERVHRCGQLEEKGQKNGARVLIPRSGARANSRES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83099</accession>
    <name>RL9_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">TP_0060</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71370">
        <property type="entry name" value="D71370"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881509.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83099"/>
    <dbReference type="SMR" id="O83099"/>
    <dbReference type="IntAct" id="O83099">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0060"/>
    <dbReference type="EnsemblBacteria" id="AAC65055">
        <property type="protein sequence ID" value="AAC65055"/>
        <property type="gene ID" value="TP_0060"/>
    </dbReference>
    <dbReference type="GeneID" id="57878600"/>
    <dbReference type="KEGG" id="tpa:TP_0060"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_12"/>
    <dbReference type="OMA" id="CKDGKAN"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176699" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="156" mass="17504" checksum="7F68DC735D64EB1C" modified="1998-11-01" version="1">MKIILNQDVKILGEEGDVKEVAAGYFRNYLYPRNLAVPHNRFTVARFKQRQQDIEMRKSLKRQDAANLKARLEAQPVVIAMPAGTNGKLYGAVTSHTVAEQLACMGFEVERKRVEVPGLTLKCVGNYHVTIRLYEEICAVVPVTIKNQSEADSVSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83103</accession>
    <name>Y064_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0064</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0064</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71370">
        <property type="entry name" value="H71370"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881513.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83103"/>
    <dbReference type="SMR" id="O83103"/>
    <dbReference type="IntAct" id="O83103">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0064"/>
    <dbReference type="EnsemblBacteria" id="AAC65064">
        <property type="protein sequence ID" value="AAC65064"/>
        <property type="gene ID" value="TP_0064"/>
    </dbReference>
    <dbReference type="GeneID" id="57878604"/>
    <dbReference type="KEGG" id="tpa:TP_0064"/>
    <dbReference type="eggNOG" id="ENOG502ZM16">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122425_0_0_12"/>
    <dbReference type="OMA" id="TRIEGIY"/>
    <dbReference type="OrthoDB" id="1518607at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202183" description="Uncharacterized protein TP_0064">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <sequence length="191" mass="22079" checksum="2837931F910CD831" modified="1998-11-01" version="1">MLPTAQRRLRGYIRACAPYGRRGEEPVRRRCAFLCARVGHVCVGRSVVQNFVFQDNIYHLARSIDVLYEGLQLNLDECLYAEKVVYDVRFFDHALQKLCAHIDRQSHFPDYLPILHCLFSCGARFLNLLNFLIHRASPVTAQVEFTRMLPFIEKRHSALHENLARSIQEVDTSADASHVVSQDEIDELLEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83109</accession>
    <name>Y070_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0070</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0070</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71371">
        <property type="entry name" value="F71371"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881519.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83109"/>
    <dbReference type="IntAct" id="O83109">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0070"/>
    <dbReference type="EnsemblBacteria" id="AAC65067">
        <property type="protein sequence ID" value="AAC65067"/>
        <property type="gene ID" value="TP_0070"/>
    </dbReference>
    <dbReference type="GeneID" id="57878610"/>
    <dbReference type="KEGG" id="tpa:TP_0070"/>
    <dbReference type="eggNOG" id="ENOG502ZJPR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154627_0_0_12"/>
    <dbReference type="OMA" id="MIQFYFL"/>
    <dbReference type="OrthoDB" id="1748591at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202186" description="Uncharacterized protein TP_0070">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="128" mass="13552" checksum="81B55415B523D5DF" modified="1998-11-01" version="1">MLPFYFLSVATNAAIGFILTVLDSQEESAHDCPFLYDATFSLVLALLSGIAAVCKCVNPIGAQLPVLGDLIPTLAGGTGCALFLHRYCVALSKPSPIPRTLVQYAKPLGLFSLAASILHLLFAPTLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83121</accession>
    <name>O83121_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4015 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71367">
        <property type="entry name" value="D71367"/>
    </dbReference>
    <dbReference type="IntAct" id="O83121">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0083"/>
    <dbReference type="EnsemblBacteria" id="AAC65079">
        <property type="protein sequence ID" value="AAC65079"/>
        <property type="gene ID" value="TP_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0083"/>
    <dbReference type="eggNOG" id="COG1306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643942_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025275">
        <property type="entry name" value="DUF4015"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13200">
        <property type="entry name" value="DUF4015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4015" evidence="2">
        <location>
            <begin position="65"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="426" mass="48441" checksum="1FB265CF5B383399" modified="1998-11-01" version="1">MPRPFDLARLEQDLRRIPDQILCAWVPRHVSQTGDALSLSELWLLHDRSSLAKEGRFARADLKKGIYVPAHHIKDPKLRAMHFKTIADNKLNMLVYDMKDELGMVRYQSQDPFVRSVGAVRPFVDMKTFVKQAKEKKLYLIARIVVFKDKYLFRWNGFELAVKAGGKPWQGYKNGALRKEEIHEHWVDPYNEKVWRYNVAIAKEAIEFGFDEVQFDYIRFPTDGDNLHQAEYPARESGMDRESALMSFLAYARERIDAPISIDIYGANGWYRTGARTGQDVELLAEYVDVICPMFYPSHFSQSFLAYAPAQERPYRIYYYGGTATGCWPATGWSSDPGCRPSTYRSLTTGRTTARITCSARWLASANQSMKDTRTGTTQGVTQTSGPTARASVSRQGNPASGRPLLGRFPTQDRKSASVLSGEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83157</accession>
    <name>O83157_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter, ATP-binding protein (Abc)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71363">
        <property type="entry name" value="G71363"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881569.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83157">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0120"/>
    <dbReference type="EnsemblBacteria" id="AAC65110">
        <property type="protein sequence ID" value="AAC65110"/>
        <property type="gene ID" value="TP_0120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75339">
        <property type="protein sequence ID" value="AGN75339"/>
        <property type="gene ID" value="TPANIC_0120"/>
    </dbReference>
    <dbReference type="GeneID" id="57878663"/>
    <dbReference type="KEGG" id="tpa:TP_0120"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.122"/>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="VFITHEI"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015821">
        <property type="term" value="P:methionine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="269" mass="29737" checksum="4A9193EEAB885629" modified="1998-11-01" version="1">MVRLERLKKTYAGVPILRDISLEIPAHGMYGIIGKSGAGKSTLLRIMSLLEKPDEGAVFYHTTRVDLLRGAALRAQRRRIGLIFQQFHLFSSRTVFGNVAYPLEIARYARKDAYARVLHLLHLVGLADKAQARISTLSGGQKQRVAIARALAAEPAILFCDEATSALDPQTTQSILTLLKNVQCSLRLTVVLITHQMEVVRDLCDRAAVLHEGEIVEEGRVTQLFAAPRRLITQQLLSGCSFASFAKSEPFHRMSSGACAVHAIDKAHW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83169</accession>
    <name>Y133_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0133</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0133</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TP013X lipoprotein family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65124" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65124.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71363">
        <property type="entry name" value="B71363"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83169"/>
    <dbReference type="IntAct" id="O83169">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0133"/>
    <dbReference type="PRIDE" id="O83169"/>
    <dbReference type="EnsemblBacteria" id="AAC65124">
        <property type="protein sequence ID" value="AAC65124"/>
        <property type="gene ID" value="TP_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0133"/>
    <dbReference type="HOGENOM" id="CLU_056007_0_0_12"/>
    <dbReference type="OMA" id="SAAQKWN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018065" description="Uncharacterized lipoprotein TP_0133">
        <location>
            <begin position="30"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="409" mass="43096" checksum="C46E28126C36F65E" modified="2001-06-01" version="2" precursor="true">MARSRCVHRVVHQAACIGVIGLSTSALTTCDFTGIFVAIQSEVPIKTPSIPGAIYGLVKAGSKLYATNGQLWKKNVAEEGKDWERESCFDSVIGDSRITSLAADNGENGVLVACILGKGAYKWSQGSADQTSGNPSALSGTEKALSVVGTGTSCVYLNHTDDKVGETSSSESGGMTASGETNEFCLHAGNGFLVTTKKVCVGSDGSPVAKSDGEEPVPPILAATDDGSGHVYILTKDKVYCKKVNQSEGKIQDCPQSAAAAPEPTGAHSVAHKVADAHSIAFFKNGSDEFLLIGGRQGYGEIKLERGSGSNGNGAQCVHLKEENVHDQTGWHEKGSTPKGSAEQYRSTIGRWAVSGIYVIKKSTSGGRGKRSTSTDCERPDLYVAVGDTNDTYTGLWRFDSAAQKWNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83177</accession>
    <name>O83177_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA-protein-cysteine S-methyltransferase (Dat)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71360">
        <property type="entry name" value="G71360"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881589.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0141"/>
    <dbReference type="EnsemblBacteria" id="AAC65129">
        <property type="protein sequence ID" value="AAC65129"/>
        <property type="gene ID" value="TP_0141"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75361">
        <property type="protein sequence ID" value="AGN75361"/>
        <property type="gene ID" value="TPANIC_0141"/>
    </dbReference>
    <dbReference type="GeneID" id="57878683"/>
    <dbReference type="KEGG" id="tpa:TP_0141"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.146"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_12"/>
    <dbReference type="OMA" id="INNPKSC"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="177" mass="19379" checksum="35B928FA8F8CB429" modified="1998-11-01" version="1">MSVHQGGIRFPLLYLEMETPLGRMCIAERAHTIVYVWFHRVGPRGSPVSGVCAQHVCPGKTALLRETQSQIHAYFCGALREFSVPVTVEGTPFMQRVWGATRNIAYGTTKSYAQLSQDIGCPRAARAVGQALHRNPLLLLIPCHRVISARASIGGFAYGSALKHFLLQQEAAVCACE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83183</accession>
    <name>Y148_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0148</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0148</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71361">
        <property type="entry name" value="E71361"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881595.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83183"/>
    <dbReference type="IntAct" id="O83183">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0148"/>
    <dbReference type="EnsemblBacteria" id="AAC65140">
        <property type="protein sequence ID" value="AAC65140"/>
        <property type="gene ID" value="TP_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0148"/>
    <dbReference type="eggNOG" id="ENOG5032PC1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433901_0_0_12"/>
    <dbReference type="OrthoDB" id="1535489at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202200" description="Uncharacterized protein TP_0148">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="192" mass="21083" checksum="D85FBDB80F7A89F7" modified="1998-11-01" version="1">MVTMVPPLFFVCALFFAEGIGLDRLCIAALSPRCTLFHTCRFLFLGGILITGNWVCIHYVYDPLALRFLTPLGVGASAFCLSTCSGKLSRTCTSHRAQSEWGLLYALVFYITYTALNLFEALVMWGVSCVGFLCFSTILRAIHQRITQGNGTAVEKTAALLLASMGFIALSLYGTDELWLFPIPAAGMRTRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83184</accession>
    <name>Y149_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0149</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0149</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71361">
        <property type="entry name" value="F71361"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881596.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83184"/>
    <dbReference type="IntAct" id="O83184">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0149"/>
    <dbReference type="EnsemblBacteria" id="AAC65141">
        <property type="protein sequence ID" value="AAC65141"/>
        <property type="gene ID" value="TP_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0149"/>
    <dbReference type="eggNOG" id="ENOG5032I09">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377595_0_0_12"/>
    <dbReference type="OMA" id="REFFAFG"/>
    <dbReference type="OrthoDB" id="1834273at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202201" description="Uncharacterized protein TP_0149">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="197" mass="21542" checksum="B4EE40FD4BE9BD81" modified="1998-11-01" version="1">MSKYTVKRASVLCIFGIGLFVPATGTFACGLLLVLGFWVLFFSSLLARFLSQFFMRTRSAPLFEVCLTLSATIMYDNLIQGFFPLVRMMLCPYLFITALSRTLDLCLTAYDADAESLECVGVFGIMIAGISLVRELVAFGCVSLPAPSGFLRIISFPPSNVIRFAATGAGTLISCGIVLWIFRSAGNDHTPSLRSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83192</accession>
    <name>O83192_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71359">
        <property type="entry name" value="C71359"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881604.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83192">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0157"/>
    <dbReference type="EnsemblBacteria" id="AAC65147">
        <property type="protein sequence ID" value="AAC65147"/>
        <property type="gene ID" value="TP_0157"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75376">
        <property type="protein sequence ID" value="AGN75376"/>
        <property type="gene ID" value="TPANIC_0157"/>
    </dbReference>
    <dbReference type="GeneID" id="57878700"/>
    <dbReference type="KEGG" id="tpa:TP_0157"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.164"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080737_0_0_12"/>
    <dbReference type="OMA" id="EHYSNMD"/>
    <dbReference type="OrthoDB" id="706925at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="300" mass="34469" checksum="3D81E706DA564436" modified="1998-11-01" version="1">MSIHSLQQTFSDIVPLLEQYTRADRFMREDNLLHERNEPIRRIVESLVARILLPGSTMRGNEQIASFLHKTNEGKRGLILAEHYSNFDLPCLLYLMEQGSSAGRMLSEKIVSIAGIKLREENRILAMLTEGYDHLVIYPSRSLATITDAHCLARETKRSRALNRAAMKYLEELRNAGKVILVFPAGTRYRPGRPETKRGVREVYSYIKHAEVLLLISINGNCLRVAERSTDMTEDAVHPDVVLLEARTVDDCALFREKALDWHRTHNVAAPSEDKKQIVVDYVMHLLEEMHEHNERERLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83207</accession>
    <name>Y177_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0177</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0177</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71358">
        <property type="entry name" value="F71358"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881624.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83207"/>
    <dbReference type="IntAct" id="O83207">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0177"/>
    <dbReference type="EnsemblBacteria" id="AAC65167">
        <property type="protein sequence ID" value="AAC65167"/>
        <property type="gene ID" value="TP_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0177"/>
    <dbReference type="HOGENOM" id="CLU_037954_1_0_12"/>
    <dbReference type="OMA" id="THARPYS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202208" description="Uncharacterized protein TP_0177">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <sequence length="436" mass="49533" checksum="50A9DC1D838057AB" modified="1998-11-01" version="1">MSRTPRSFCGHAFHMQSLSQFDTQTMRSLHPISSGTQSGDQTARSLHSFLINHIPDELLGQTAFVPWEPANRIWRAQAQSTWQEITYTIKVIQSEIATRIYFGKRWLLNTLRNVFFLERPVRVCLTAPEVLCVAAGFGLEQITRVGLPIVAVSSALQALLYRNISPDICMSTDGSFWAAEHFPPAPTLPVLFPLEACIPPRVFKYSPISLLNYHSHTEHFFLQHLHIPSVSAQRHGSVMGTALEYLLQCGVHSIYLAGLDLHPGKGFQHARPHASFKRFNPKRTEPLATCIAGNFDNRSLETYAHWFYSLPQEKIQKLTRLNTEHAPPSNVRTITYEDFSQHAFAKKDTFTFSEGPPISRIHKKAVLRHYFERITRSAHHARIASSIASSGIEKEAFEFLAYAELLHLRKNPSQGTQTLIHKVRHEIVQLRNKLSI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83211</accession>
    <name>Y181_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0181</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0181</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71353">
        <property type="entry name" value="G71353"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881628.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83211"/>
    <dbReference type="SMR" id="O83211"/>
    <dbReference type="STRING" id="243276.TPANIC_0181"/>
    <dbReference type="EnsemblBacteria" id="AAC65194">
        <property type="protein sequence ID" value="AAC65194"/>
        <property type="gene ID" value="TP_0181"/>
    </dbReference>
    <dbReference type="GeneID" id="57878719"/>
    <dbReference type="KEGG" id="tpa:TP_0181"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146778_0_0_12"/>
    <dbReference type="OMA" id="ELMVINH"/>
    <dbReference type="OrthoDB" id="1677401at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202212" description="Uncharacterized protein TP_0181">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="147" mass="16464" checksum="F680BA906C6BEA77" modified="1998-11-01" version="1">MRIYLRVVLPLSLALNSYGVLAFFWGERGVCAMRLLEREKKELVHHIQTLAERGRDLAAVVDALSFDEETIGAYARQLGYVRAGDVLVRPVNFTVAHMHTLDSGDARPLVAPACFSDTRCKVYALCVGFFVVLLQLLWGSARAYFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83216</accession>
    <name>O83216_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxygen-independent coproporphyrinogen III oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71354">
        <property type="entry name" value="D71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881633.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0186"/>
    <dbReference type="EnsemblBacteria" id="AAC65171">
        <property type="protein sequence ID" value="AAC65171"/>
        <property type="gene ID" value="TP_0186"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75400">
        <property type="protein sequence ID" value="AGN75400"/>
        <property type="gene ID" value="TPANIC_0186"/>
    </dbReference>
    <dbReference type="GeneID" id="57878724"/>
    <dbReference type="KEGG" id="tpa:TP_0186"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.188"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_12"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="393" mass="44105" checksum="00D697BAED537F8C" modified="1998-11-01" version="1">MSSEVGASLYVHIPFCAQRCAYCDFYSLVRSTYFRPHQPCPHFIDRLLQDVALQRECFGVQGWQTVYMGGGTPSLLAPQDIRHFCVALRAAQRYPIQEFTLEVNPEDVTEEFLCACAEGGVNRLSLGVQSLRDEVLRAERRAASAECARTALRVMTANARFFSGGVRISADLIAGLRGQTARMVREDIDELLSFGLRHVSLYGLCVPHPTETQEERIAALWAHGSAYLVRAGFNRYELSNFARTAADESAHNRAYWRMAPHAGVGPGAVGTRFVNLSLSKEGAWAIRSTVRKHLGQYLAEVCRENVYEHEFLTEHMCVQEALLMGLRLEQGLDVVTFRARFGKGIEAYIGKTIARWQCHGRMQRTATSLRLSAQARVFLDSFLREAFAELART</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83229</accession>
    <name>RL14_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">TP_0199</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="PLoS Genet." volume="8" first="E1002815" last="E1002815">
            <title>RsfA (YbeB) proteins are conserved ribosomal silencing factors.</title>
            <authorList>
                <person name="Hauser R."/>
                <person name="Pech M."/>
                <person name="Kijek J."/>
                <person name="Yamamoto H."/>
                <person name="Titz B."/>
                <person name="Naeve F."/>
                <person name="Tovchigrechko A."/>
                <person name="Yamamoto K."/>
                <person name="Szaflarski W."/>
                <person name="Takeuchi N."/>
                <person name="Stellberger T."/>
                <person name="Diefenbacher M.E."/>
                <person name="Nierhaus K.H."/>
                <person name="Uetz P."/>
            </authorList>
            <dbReference type="PubMed" id="22829778"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1002815"/>
        </citation>
        <scope>INTERACTION WITH RSFS</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8 (By similarity). Interacts with ribosomal silencing factor RsfS, which may inhibit ribosomal subunit association.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71356">
        <property type="entry name" value="A71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881646.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83229"/>
    <dbReference type="SMR" id="O83229"/>
    <dbReference type="IntAct" id="O83229">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0199"/>
    <dbReference type="EnsemblBacteria" id="AAC65184">
        <property type="protein sequence ID" value="AAC65184"/>
        <property type="gene ID" value="TP_0199"/>
    </dbReference>
    <dbReference type="GeneID" id="57878737"/>
    <dbReference type="KEGG" id="tpa:TP_0199"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_12"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000128568" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22829778"/>
        </source>
    </evidence>
    <sequence length="122" mass="13359" checksum="971E6D3DDA6ED85B" modified="1998-11-01" version="1">MIQVQSRLNVADNSGARLVQCIKVVGGSRRRYASVGDIIVVAVKDALPTSVIKKGSVEKAVIVRVSKEYRRVDGTYIRFDDNACVVIDANGNPKGKRIFGPVARELRDMDFTKIVSLAPEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83232</accession>
    <name>RS14Z_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">TP_0202</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71356">
        <property type="entry name" value="D71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881649.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83232"/>
    <dbReference type="SMR" id="O83232"/>
    <dbReference type="IntAct" id="O83232">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0202"/>
    <dbReference type="EnsemblBacteria" id="AAC65191">
        <property type="protein sequence ID" value="AAC65191"/>
        <property type="gene ID" value="TP_0202"/>
    </dbReference>
    <dbReference type="GeneID" id="57879565"/>
    <dbReference type="KEGG" id="tpa:TP_0202"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_12"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000130957" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="6986" checksum="26FB261254DCA152" modified="1998-11-01" version="1">MATVAMINKAKATPKYATRRYNRCGVCGRPRGYMRRFQLCRLCFRKLASEGQIPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83248</accession>
    <name>O83248_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor SigG regulation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71352">
        <property type="entry name" value="H71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881667.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0219"/>
    <dbReference type="EnsemblBacteria" id="AAC65206">
        <property type="protein sequence ID" value="AAC65206"/>
        <property type="gene ID" value="TP_0219"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75433">
        <property type="protein sequence ID" value="AGN75433"/>
        <property type="gene ID" value="TPANIC_0219"/>
    </dbReference>
    <dbReference type="GeneID" id="57878757"/>
    <dbReference type="KEGG" id="tpa:TP_0219"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.223"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023575_0_0_12"/>
    <dbReference type="OMA" id="MSQMKGV"/>
    <dbReference type="OrthoDB" id="736514at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="488"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="715" mass="81440" checksum="AB69F260F326E02D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83261</accession>
    <name>O83261_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71349">
        <property type="entry name" value="C71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881681.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83261">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0233"/>
    <dbReference type="EnsemblBacteria" id="AAC65221">
        <property type="protein sequence ID" value="AAC65221"/>
        <property type="gene ID" value="TP_0233"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75445">
        <property type="protein sequence ID" value="AGN75445"/>
        <property type="gene ID" value="TPANIC_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0233"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.251"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488387_0_0_12"/>
    <dbReference type="OMA" id="FFNIKDN"/>
    <dbReference type="OrthoDB" id="1225401at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="181" mass="20002" checksum="574BDDC72C097047" modified="1998-11-01" version="1">MGTVVPGFDDEKDESLKMNLQKIDDLEGGVVVFLNGYIDTYNSSFFQKRIAKVIDAGYTRIVFNCASLNYVSSTGIGSFTAFLKTVKPKGGDIVLLDIQPRVYEVFQLLGFSQFFNIRDSIADAVSLFRNKVSPLKVDTFPKVFSCPICSKKLKATKQGRFRCSECKTILALDASAHVSLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83265</accession>
    <name>RL11_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">TP_0237</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71349">
        <property type="entry name" value="G71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881685.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83265"/>
    <dbReference type="SMR" id="O83265"/>
    <dbReference type="IntAct" id="O83265">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0237"/>
    <dbReference type="EnsemblBacteria" id="AAC65225">
        <property type="protein sequence ID" value="AAC65225"/>
        <property type="gene ID" value="TP_0237"/>
    </dbReference>
    <dbReference type="GeneID" id="57878779"/>
    <dbReference type="KEGG" id="tpa:TP_0237"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_12"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104403" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="146" mass="15376" checksum="23EBFE0B7F7B8F2E" modified="1998-11-01" version="1">MAAKKKVVTQIKLQCPAGKATPAPPVGPALGPHGVSAPQFVQQFNDRTKSMEPGLVVPVVVTVYSDKSFSFVLKTPPAAVLIRKACGIEKGSTNSVKQKVARLSLAQLTEIAQVKLPDMSALTLDAAKRIIAGTARSMGVEVERSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83274</accession>
    <name>Y246_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0246</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0246</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71348">
        <property type="entry name" value="A71348"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83274"/>
    <dbReference type="STRING" id="243276.TPANIC_0246"/>
    <dbReference type="EnsemblBacteria" id="AAC65240">
        <property type="protein sequence ID" value="AAC65240"/>
        <property type="gene ID" value="TP_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0246"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423186_0_0_12"/>
    <dbReference type="OMA" id="NQIMWHI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202218" description="Uncharacterized protein TP_0246">
        <location>
            <begin position="1"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="378"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00219"/>
        </source>
    </evidence>
    <sequence length="597" mass="69814" checksum="BAF44661C4FDFB4D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83291</accession>
    <name>O83291_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71345">
        <property type="entry name" value="E71345"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881716.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83291">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0267"/>
    <dbReference type="EnsemblBacteria" id="AAC65255">
        <property type="protein sequence ID" value="AAC65255"/>
        <property type="gene ID" value="TP_0267"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75478">
        <property type="protein sequence ID" value="AGN75478"/>
        <property type="gene ID" value="TPANIC_0267"/>
    </dbReference>
    <dbReference type="GeneID" id="57878811"/>
    <dbReference type="KEGG" id="tpa:TP_0267"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.271"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_4_2_12"/>
    <dbReference type="OMA" id="FEGSCEM"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13014" checksum="E8323104D3093B64" modified="1998-11-01" version="1">MASAHSFDLVDLDDEDYGTILAEDVEFSGTVRFEEPFMVRGVFEGSIESSGDLMVEEQARVRAEIVADRVVIKGEVIGNVTAMSVVRVFPCGRLIGDVTAPEVVLESGCFFSGVCSMPESG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83293</accession>
    <name>MTAB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB</fullName>
            <ecNumber>2.8.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>tRNA-t(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">mtaB</name>
        <name type="ordered locus">TP_0269</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylthiotransferase family. MtaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71345">
        <property type="entry name" value="G71345"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881718.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83293"/>
    <dbReference type="SMR" id="O83293"/>
    <dbReference type="IntAct" id="O83293">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0269"/>
    <dbReference type="EnsemblBacteria" id="AAC65257">
        <property type="protein sequence ID" value="AAC65257"/>
        <property type="gene ID" value="TP_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0269"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_12"/>
    <dbReference type="OMA" id="HFHIPLQ"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000141755" description="Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="199"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P54462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="482" mass="53173" checksum="FE93DA4FAD2D276D" modified="1998-11-01" version="1">MFSVRIETLGCRLNHVESESLAALFLQEGFAVCRGNTSTAPVVLCVINTCTVTSKAEQKARRLVRLLLRTYPTAIALVTGCYAQLEPASLEAMDDRVLAFPGKQKDALSLLPSCLRALLVQRGPAPIDQYVCGMRALLASLKKKIISLELTSEFPSQTHMPTRNALPQLTGVPHAPRVSVSSFSEPTAVPRFALYAPRFLFHSRASIKVQDGCNSGCAFCRIRFARGRAVSLETHEVIGRVQALEARGMSEVVLTGVNLSQYRSGSIDFAGLLELIVQETHTIHIRISSLYPESVTSAFLRAIAHTRVSPHFHLSVQSGSDRVLRRMRRAYTRADIYQAVSDLRSVREEPFLGCDIIVGFPGETEEDFADTQRMCKTLRFAGIHVFPFSARPGTEAFAMDAKVPQRIAGERVAAMQQLAEKNYRAYLEYWNGRELCAVVEQSVARVLTENYLSLPIIERGGVAASAGSHVRIRVHNEGAILL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83295</accession>
    <name>PARB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable chromosome-partitioning protein ParB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">parB</name>
        <name type="ordered locus">TP_0271</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71346">
        <property type="entry name" value="A71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881720.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83295"/>
    <dbReference type="SMR" id="O83295"/>
    <dbReference type="IntAct" id="O83295">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0271"/>
    <dbReference type="EnsemblBacteria" id="AAC65259">
        <property type="protein sequence ID" value="AAC65259"/>
        <property type="gene ID" value="TP_0271"/>
    </dbReference>
    <dbReference type="GeneID" id="57878815"/>
    <dbReference type="KEGG" id="tpa:TP_0271"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_12"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000178692" description="Probable chromosome-partitioning protein ParB">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="324" mass="35430" checksum="DCCF790B2EB84276" modified="1998-11-01" version="1">MGKDKLGKGIDALLQESSDRYDVRDSGGVQTVHYLDPTLLQANPHQARRTFAQESLEELAASIREHGVIQPVLAEKNQDGSWVIIAGERRTRAAILAGLNRIPVIVRTCDHEKKLAIALIENVQRENLNPLEEARAYQHIMDLGNLSHEELAQRVGKNRSTITNALRLLKLPPEVQQSLSSRTLSAGHARALLSLTDMQLCVSVAQYVVTHALSVRAAEECVACLNRGGSLHDYAGARAHTAASSPSPGGSATDITRLPPSSPSTDAQLDARIRNADIADIEQQLLEQLGTKVRISGNLQRGRIEITYFSQAELERLYGLLKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83299</accession>
    <name>O83299_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetyl-D-mannosamine transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71342">
        <property type="entry name" value="F71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881724.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83299">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0275"/>
    <dbReference type="CAZy" id="GT26">
        <property type="family name" value="Glycosyltransferase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65263">
        <property type="protein sequence ID" value="AAC65263"/>
        <property type="gene ID" value="TP_0275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75486">
        <property type="protein sequence ID" value="AGN75486"/>
        <property type="gene ID" value="TPANIC_0275"/>
    </dbReference>
    <dbReference type="GeneID" id="57878819"/>
    <dbReference type="KEGG" id="tpa:TP_0275"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.279"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_12"/>
    <dbReference type="OMA" id="KEPRRMW"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28940" checksum="B7D9DD4CDB35A33B" modified="1998-11-01" version="1">MEQTQLVTRIEFLSVPLDVVREEYLCTVILSLLEKKEPQHIIFLSLWDVLKARHNHEFRTMVGRAALCLPTSYSIVRGARFLGLPTPIFRHPFQFIITLLNVMDTHYKSLYLFGGRGQSLLEAERNVHSTFPGLSVVGRFHGFYRKTLENNIITAIVKSNASLVIVGNGVPGGVRWIARNRAHFAGGIFVQDSEVIDIFSKRRKRPRAKELLHGRSPWGQTLHPLRWHRSVRYVWYIFLLLFYRIFRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83311</accession>
    <name>O83311_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71344">
        <property type="entry name" value="B71344"/>
    </dbReference>
    <dbReference type="IntAct" id="O83311">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0286"/>
    <dbReference type="EnsemblBacteria" id="AAC65269">
        <property type="protein sequence ID" value="AAC65269"/>
        <property type="gene ID" value="TP_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0287"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1325875_0_0_12"/>
    <dbReference type="OMA" id="ERHAHRS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="207" mass="24202" checksum="F1F622EE7F6F1446" modified="1998-11-01" version="1">MERHAHRSAGMSQHIQDILRTNTHMCIAPQLCSSHSTVLPTQIVPALRKSDFFTQPTECTTNHTPTIYPYDFVGIYHRDRFIQCGGFDFTIANAYWQNLDFGLRSYLWGECIEVNTQIRLFYEALPPQEDASADGSYRIFYLKNLAPLLEKDRAFISGTQFFSFFRNSGLHLIEAYRLFRDAQKWVAVNRYRFKKTAARLVSEWEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83317</accession>
    <name>O83317_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71345">
        <property type="entry name" value="A71345"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881743.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83317">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0294"/>
    <dbReference type="EnsemblBacteria" id="AAC65273">
        <property type="protein sequence ID" value="AAC65273"/>
        <property type="gene ID" value="TP_0294"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75499">
        <property type="protein sequence ID" value="AGN75499"/>
        <property type="gene ID" value="TPANIC_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="57878831"/>
    <dbReference type="KEGG" id="tpa:TP_0294"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.295"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_8_0_12"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="86"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="211"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="421" mass="47431" checksum="1AE6FE05AE3B6FAB" modified="1998-11-01" version="1">MRCSGFTDLAIVACPGGEHFADETIKHLTRVCERKFHQRMDRLTDRYGLDSGSVIRDANFYRDLFSTELCAHDDVRRFNPPHFKVDAQFICFLNGELKTQINECIRGKDVFIFQDVENHQPVLVNNGKSKKIFSVNDHVMMLIVTIDAVRHAGAGRVTLVLPTYPYSRQHKKCGREGLTAGLLGSVYEYLGVSHIVTLDLHSREIENAFHRTRLENLHASYQIIRELAKIENLSDPDIPFVVVAPDSGAVERNKFYSSGLKKPLAMIYKVRDYSVVAQNAKQSNIVEINLLGDVEGKTAFIADDMLGSGGTMLKAMEFLKSRGAKQVIAAVSLPFFTGNALELFDEAYEKRYFSRIIGTNAVFHTQLSHKQWYTETDVSGLFARVIARIHHNQSLSSLLDDRSIIERLLHARLSVAGTPRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>O83338</accession>
    <name>Y318_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0318</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0318</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71340">
        <property type="entry name" value="G71340"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881766.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83338"/>
    <dbReference type="EnsemblBacteria" id="AAC65307">
        <property type="protein sequence ID" value="AAC65307"/>
        <property type="gene ID" value="TP_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0318"/>
    <dbReference type="HOGENOM" id="CLU_210505_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202234" description="Uncharacterized protein TP_0318">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <sequence length="59" mass="6123" checksum="4D5C637EE9F03973" modified="1998-11-01" version="1">MRKIRGHSVTQGDKEVQGVVSFCVCAGGRVRGLLDRAGGGGEVAWGACGGGVCCVWWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83377</accession>
    <name>O83377_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71334">
        <property type="entry name" value="D71334"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881806.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0358"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65344">
        <property type="protein sequence ID" value="AAC65344"/>
        <property type="gene ID" value="TP_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0358"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.377"/>
    <dbReference type="eggNOG" id="COG1543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_12"/>
    <dbReference type="OMA" id="CAYYEGL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="423"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="526" mass="59701" checksum="D5F0C32CADB6C41A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83379</accession>
    <name>O83379_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71334">
        <property type="entry name" value="F71334"/>
    </dbReference>
    <dbReference type="IntAct" id="O83379">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0360"/>
    <dbReference type="EnsemblBacteria" id="AAC65345">
        <property type="protein sequence ID" value="AAC65345"/>
        <property type="gene ID" value="TP_0360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75557">
        <property type="protein sequence ID" value="AGN75557"/>
        <property type="gene ID" value="TPANIC_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0360"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.359"/>
    <dbReference type="HOGENOM" id="CLU_203717_0_0_12"/>
    <dbReference type="OMA" id="KFFCSCG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="58" mass="6438" checksum="8160777031FDFC77" modified="1998-11-01" version="1">MKMAGASKNSRTAAATQRFNCPCGGEVVLRSIVDNGKVKNIAECPKCRRVERRPRDFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83390</accession>
    <name>Y375_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0375</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0375</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71330">
        <property type="entry name" value="A71330"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83390"/>
    <dbReference type="SMR" id="O83390"/>
    <dbReference type="IntAct" id="O83390">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0375"/>
    <dbReference type="EnsemblBacteria" id="AAC65380">
        <property type="protein sequence ID" value="AAC65380"/>
        <property type="gene ID" value="TP_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0375"/>
    <dbReference type="HOGENOM" id="CLU_2774752_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202245" description="Uncharacterized protein TP_0375">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <sequence length="69" mass="7354" checksum="B897D859A2B4830E" modified="1998-11-01" version="1">MASVFSFLLMSAAGFPTLSTDSSIRSSRNALTLLRWICEAVSAAVPVSRPSANCVTYKAVISKFIARIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83394</accession>
    <name>SECA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">TP_0379</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">May bind 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71330">
        <property type="entry name" value="E71330"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881827.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83394"/>
    <dbReference type="SMR" id="O83394"/>
    <dbReference type="STRING" id="243276.TPANIC_0379"/>
    <dbReference type="PRIDE" id="O83394"/>
    <dbReference type="EnsemblBacteria" id="AAC65365">
        <property type="protein sequence ID" value="AAC65365"/>
        <property type="gene ID" value="TP_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0379"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_12"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000109619" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="902"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="904"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <sequence length="916" mass="103780" checksum="EA5561F6EE7C65AE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83409</accession>
    <name>TOP1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA topoisomerase 1</fullName>
            <ecNumber evidence="1">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA topoisomerase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">topA</name>
        <name type="ordered locus">TP_0394</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71332">
        <property type="entry name" value="D71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881842.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83409"/>
    <dbReference type="SMR" id="O83409"/>
    <dbReference type="IntAct" id="O83409">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0394"/>
    <dbReference type="EnsemblBacteria" id="AAC65378">
        <property type="protein sequence ID" value="AAC65378"/>
        <property type="gene ID" value="TP_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0394"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_12"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000145170" description="DNA topoisomerase 1">
        <location>
            <begin position="1"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type 1">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type 2">
        <location>
            <begin position="628"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type 3">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="1">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <sequence length="731" mass="82441" checksum="C0F0C6C3DDD16F29" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83420</accession>
    <name>O83420_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">McbG protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71329">
        <property type="entry name" value="D71329"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0405"/>
    <dbReference type="EnsemblBacteria" id="AAC65393">
        <property type="protein sequence ID" value="AAC65393"/>
        <property type="gene ID" value="TP_0405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75599">
        <property type="protein sequence ID" value="AGN75599"/>
        <property type="gene ID" value="TPANIC_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0405"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.405"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109834_0_0_12"/>
    <dbReference type="OMA" id="CAHEGCP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="149" mass="17149" checksum="0A2F94BEFD057483" modified="1998-11-01" version="1">MYAPRMRLNRVDFSGFHFVGCNFFNTVFNACVFANVVMRMCFFERCYLVNSSFTEADIQFSSFEGSILHTVSFAHAVLLSDNFNRIHAQDVSFQESDLSHTRFLHATLATVRFENCTVQHTHFMPSHTTHCTFKGSSTEHARIYLSDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83423</accession>
    <name>O83423_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71329">
        <property type="entry name" value="G71329"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881856.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83423">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0408"/>
    <dbReference type="EnsemblBacteria" id="AAC65396">
        <property type="protein sequence ID" value="AAC65396"/>
        <property type="gene ID" value="TP_0408"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75602">
        <property type="protein sequence ID" value="AGN75602"/>
        <property type="gene ID" value="TPANIC_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0408"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.433"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004535_0_0_12"/>
    <dbReference type="OMA" id="QSLMNSM"/>
    <dbReference type="OrthoDB" id="791690at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="352"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="918"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="1084" mass="124015" checksum="C549B5501DB8F688" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83437</accession>
    <name>Y422_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0422</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0422</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71325">
        <property type="entry name" value="C71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881870.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83437"/>
    <dbReference type="IntAct" id="O83437">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0422"/>
    <dbReference type="EnsemblBacteria" id="AAC65418">
        <property type="protein sequence ID" value="AAC65418"/>
        <property type="gene ID" value="TP_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0422"/>
    <dbReference type="eggNOG" id="ENOG5032GJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796788_0_0_12"/>
    <dbReference type="OMA" id="WENETRL"/>
    <dbReference type="OrthoDB" id="866446at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202252" description="Uncharacterized protein TP_0422">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <sequence length="341" mass="37978" checksum="3376F31E7B2C2022" modified="1998-11-01" version="1">MRRLSDRLRGMTGKGWSAWVRLCVLSTQVGLAAEPALARLAGVWENATRIVAIAPTADAMRFSLMLVHKPYYAYVYERVAVFSLSSLSDARADVLPPPAAQKAERVDLVLSFEGRVRVQPLVLCRWGDALFCSFFQRVSYGTRSGSVSSEQIPVRTDDPLFGFWIEEGSAEALRAYSSQAPGELNAFFFTEANFYRFRYWRDDALAFAAQRAYFTADDGVTYEIPQYVQRGAAVYSCTTGRSRVVRNFQTGTYEVRTSSDGSKRLMLRRRGAGPGSYAVGAVYPRQGFLDESALALRVDGQFLAIGEPFLRKSAVHDVTAFIDAHNARKRAPRAPLLVPDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83442</accession>
    <name>VATB1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase beta chain 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit B 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpB1</name>
        <name type="ordered locus">TP_0427</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71325">
        <property type="entry name" value="H71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881875.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83442"/>
    <dbReference type="SMR" id="O83442"/>
    <dbReference type="IntAct" id="O83442">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0427"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65413">
        <property type="protein sequence ID" value="AAC65413"/>
        <property type="gene ID" value="TP_0427"/>
    </dbReference>
    <dbReference type="GeneID" id="57878952"/>
    <dbReference type="KEGG" id="tpa:TP_0427"/>
    <dbReference type="eggNOG" id="COG1156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_2_0_12"/>
    <dbReference type="OMA" id="GFKIKPR"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144683" description="V-type ATP synthase beta chain 1">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="430" mass="47229" checksum="26DF2DFF3B0646D9" modified="1998-11-01" version="1">MYKVYEKIESINGSVITVRAKGVHYGELARVKTAFGDSLAEVNKLEGDVVSLQVFAGGRGISTGSEVRFLGRGMLVSFSDYLLGRIFNGSGVPRDGGPALKEGRVEIGGPSVNPAKRVIARRMIRTGIPMIDVFNTLVVSQKLPIFSSSGEPYNELLARIAMQAEVDVIVLGGMGLKHDDYLYFKSALEEAGALSRAVLFVHTASDPTVECLMVPDMCLAVAEQFALKGRDVLVLLTDMTNFADAMKEIAIIQEQVPSNRGYPGDLYSQLASRYEKAVDFDDAGSVTILAVTTMPGDDVTHPVPDNTGYITEGQFYLKNGRIEPFGSLSRLKQNVNGRTRADHRALMDNMIKLYAAYRDALEKRSMGFAMSEWDEKLLTYGGLFEAQLMDLSVNIPLEEAFDTGWKILGRCFTPEETGIRSDLINTYWPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83443</accession>
    <name>VATD1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit D 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit D 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpD1</name>
        <name type="ordered locus">TP_0428</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71326">
        <property type="entry name" value="A71326"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881876.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83443"/>
    <dbReference type="SMR" id="O83443"/>
    <dbReference type="STRING" id="243276.TPANIC_0428"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65414">
        <property type="protein sequence ID" value="AAC65414"/>
        <property type="gene ID" value="TP_0428"/>
    </dbReference>
    <dbReference type="GeneID" id="57878953"/>
    <dbReference type="KEGG" id="tpa:TP_0428"/>
    <dbReference type="eggNOG" id="COG1394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113661_0_0_12"/>
    <dbReference type="OMA" id="VQIPGYK"/>
    <dbReference type="OrthoDB" id="1204844at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144273" description="V-type ATP synthase subunit D 1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="206" mass="23803" checksum="BC33C36FC5795483" modified="1998-11-01" version="1">MAVRLTKNELKRQKETLKTFRRFLPTLQLKKQQLYAEIRAVEARASEVRSRADALRQDVQQWVAVFSESGVFDARLLRVQEVKKTYASIAGVRIPCFLEVHFACPPYDLYRVPLWVDTAVRKMQEVLSLDLEAHVLDEQALLLGAELRTTTQRVNLFEKVKIPETRACIRKITVYLGDQQVAAVVRGKMSKKNLVDVSRMEQEDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83448</accession>
    <name>O83448_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71326">
        <property type="entry name" value="F71326"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0433"/>
    <dbReference type="EnsemblBacteria" id="AAC65421">
        <property type="protein sequence ID" value="AAC65421"/>
        <property type="gene ID" value="TP_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0433"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085618_0_0_12"/>
    <dbReference type="OMA" id="EREVEDX"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="256" mass="27454" checksum="E90329D25A119E76" modified="1998-11-01" version="1">MIKRHMFAKRGVKGRSYLVRVNTAFLVLCVASVTPLWAVWEGNAEIGPQGSFLQDGMFVRSDMFPKNTAVEISNLEKNAKAQAVVIGHAGIPGLLVSLAPAAAAQLGIGVYQAVRVRVRTLGTVRGGSQTSQDGLSLASLPSRVPARPAQRDPLSSPPAGHTVPEYRDTVIFDDPRLVSPLSREVEDAPKVVEPASEREGGEREVEDAPKVVEPASEREGGEREVEDXPKVVEPASEREGGEREVEDVPKVRGAGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83452</accession>
    <name>IXTPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0438</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71323">
        <property type="entry name" value="F71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881886.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83452"/>
    <dbReference type="SMR" id="O83452"/>
    <dbReference type="STRING" id="243276.TPANIC_0438"/>
    <dbReference type="EnsemblBacteria" id="AAC65425">
        <property type="protein sequence ID" value="AAC65425"/>
        <property type="gene ID" value="TP_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0438"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_12"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000178257" description="dITP/XTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <sequence length="269" mass="30009" checksum="0FB9648143E174C2" modified="1998-11-01" version="1">MRAVDFLRRATVCWYMRIYLASNNAHKHAEFSSLFPMHTILLPKDEGIDFFSPEDGSTFFANARQKADALYDVVHAPVLADDSGLCVDALDGDPGVHSARFGAQHGVHTDTARMQLLLERMHGRQDRACSFVCVAVLKLGSVPLCVGRGVCRGVLTTEMSGVEGFGYDPIFLLPHLGRTFAQLSIEEKNRVSHRALAALRLAQVLAMMQLPRALRYELKLLRGARRMTRGGVLRPGAPCAQRKGQTAQTARRHKFYARARRCARRIHRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83467</accession>
    <name>Y454_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0454</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0454</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71322">
        <property type="entry name" value="G71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881903.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83467"/>
    <dbReference type="SMR" id="O83467"/>
    <dbReference type="STRING" id="243276.TPANIC_0454"/>
    <dbReference type="EnsemblBacteria" id="AAC65444">
        <property type="protein sequence ID" value="AAC65444"/>
        <property type="gene ID" value="TP_0454"/>
    </dbReference>
    <dbReference type="GeneID" id="57878978"/>
    <dbReference type="KEGG" id="tpa:TP_0454"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170086_0_0_12"/>
    <dbReference type="OMA" id="KAMDNID"/>
    <dbReference type="OrthoDB" id="1602781at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202257" description="Uncharacterized protein TP_0454">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <sequence length="229" mass="24912" checksum="074482F285CC13B8" modified="1998-11-01" version="1">MMKALLVADDPVSVNLVFENHTQCGYEVIHYRSALKALDNMEEIQPQLLFINASDFPRHWRVLTQFFKHQSVCGARVILLVNTPSSSLSARQVAQAGVHALIDYTLSPEEGRKALCGVLTPSACAGSVDVGHAHTCQADFVFTNPCSGSIVTGTVREVSEEGVDFIPDFPASVNNLQEQDVLEHCALKVAHDILGVRCSFHSSDGRILLRFIDPDASLVHAVRSVTGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83474</accession>
    <name>O83474_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71320">
        <property type="entry name" value="G71320"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881910.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83474">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0461"/>
    <dbReference type="EnsemblBacteria" id="AAC65454">
        <property type="protein sequence ID" value="AAC65454"/>
        <property type="gene ID" value="TP_0461"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75655">
        <property type="protein sequence ID" value="AGN75655"/>
        <property type="gene ID" value="TPANIC_0461"/>
    </dbReference>
    <dbReference type="GeneID" id="57878985"/>
    <dbReference type="KEGG" id="tpa:TP_0461"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.461"/>
    <dbReference type="HOGENOM" id="CLU_143567_0_0_12"/>
    <dbReference type="OMA" id="TGKMEGI"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13029" checksum="24F4A1BDA63530AF" modified="1998-11-01" version="1">MLQAAACGAMRGGVLEYTGKMEGMGVRVERVRCEQNLSKTAFARELGIGVEELDAIERGTMPLSRDLTLLLCVVFAVNRLWLESGEGEPFSASAVSPQETVQPEEEAREPPIPPPRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83482</accession>
    <name>O83482_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71321">
        <property type="entry name" value="G71321"/>
    </dbReference>
    <dbReference type="IntAct" id="O83482">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0468"/>
    <dbReference type="EnsemblBacteria" id="AAC65450">
        <property type="protein sequence ID" value="AAC65450"/>
        <property type="gene ID" value="TP_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0469"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028029_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="487" mass="54109" checksum="3CECA6A87BBF7DDA" modified="1998-11-01" version="1">MNNVHKTFIALAAGLVLLLAVVAGFSLFSRGVVRARLPRAAGETLLEEEGVSEQELAWLETNQLLQEQGEEPGVLVDHHVQLSGNSDEEQFLQTLSEELAPQRPVPYAPTPRERMQEQDTRQKGARVLTPPRGVSRTASFSPEKSIKRAVQIATRPEVRAPAETATPQHHVHALLSEGKELTERRDYPGAVRVFNKAIRALPAGDAVFAADAYTRMGEAMYALSQHDNRDGFERTRALETATVYVKEALRLNPRSAAAHYLAACIADAQPDDDQTTALTLLERAAALDRREYRYSYELGKRLFAVRRFAEAQEAFNAATVANPKFEPAFFNLGLTCRVRAKHDLALQAFRAVIRLNPTHTRAWIELGRVHDAQGEVSAALADYQKAQECAAAAEAHDLYLTAARERARVLAKSGAKEEAVRLFQEILERDSEDALTLYNLATVLLDLDRNEEALKHAQQAVYANGSQARFLYASCLQRKKQGVWILP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83494</accession>
    <name>Y481_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0481</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0481</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71319">
        <property type="entry name" value="G71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881930.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83494"/>
    <dbReference type="SMR" id="O83494"/>
    <dbReference type="IntAct" id="O83494">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0481"/>
    <dbReference type="EnsemblBacteria" id="AAC65470">
        <property type="protein sequence ID" value="AAC65470"/>
        <property type="gene ID" value="TP_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0481"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.513"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572289_0_0_12"/>
    <dbReference type="OMA" id="INANMEI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202263" description="Uncharacterized protein TP_0481">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="477" mass="53153" checksum="D32B041577BE4120" modified="1998-11-01" version="1">MSDDSTPKTPSRRIRHTGRRRTLHRFFCKRYTPRSLKRFLRRIHIPADRAYCMRYLADPVSTPVRVFGRTLLSRTYVRFDQQAIAHSADLKRLNAIAASIAKQRGRVNFWSLSMACASVLALLGLVYLIRNVIARRVVIGGSEAVFGARCEAAVVDLDLFNARFRLKNYAVANKHHPMWNLFEIESIDIHFDLLELSRGKFVSHTMVVEGVTWNTPRKTSGALPPRRAKRQRVRSSNPLIAKIQEKAAELAAPVSFGAGFSALKAQVDPRILLEREVKALKTPTLVQHVGAQAPKLAERWTQRVFDAHARAEKTVAAIRAVTELDFHALKDVSAIKQGIETLDRARRSTEEALATARTISHELQQDVHSTLGLAREFAAAVKADGARIARAAAAIRDIQADGGKKFISGLCTVFLARSFSHYYPYVAQMLDYVRGSQRTPSDGSPSAEAEKTAQSLTTRKRLQGVIFCLSATSLPCC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83495</accession>
    <name>Y482_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0482</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0482</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71319">
        <property type="entry name" value="H71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881931.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83495"/>
    <dbReference type="SMR" id="O83495"/>
    <dbReference type="EnsemblBacteria" id="AAC65471">
        <property type="protein sequence ID" value="AAC65471"/>
        <property type="gene ID" value="TP_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0482"/>
    <dbReference type="HOGENOM" id="CLU_986742_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202264" description="Uncharacterized protein TP_0482">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="282" mass="30611" checksum="99A84614896B3B45" modified="1998-11-01" version="1">MFERNVPSVLLRNIGVSAADPQARFSVAARVRNASNDAHGFGEPISFLLDVAAGAQDASLRGVVDLRRAHPDLVDVSCTARGIPLAVPAPAEGFPELSGVLGLHTQVFVRKDHSVELKMGARISDSVLRAAPFEPRVLFDVYADVLRQIRQIAFEATVRVSAEGALSISVESDADGAFVRALSRAFAQQVDALRRAVIAEGERFLAQQRRVYAQEIAQVTQLVSRAEDAIAQLGVSSRVIQQKRAEAERLLEAAARKALGEVTKRAADELQNKARDAFRSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83501</accession>
    <name>O83501_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein (Mcp2-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TP_0488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71317">
        <property type="entry name" value="H71317"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881937.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0488"/>
    <dbReference type="EnsemblBacteria" id="AAC65475">
        <property type="protein sequence ID" value="AAC65475"/>
        <property type="gene ID" value="TP_0488"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75679">
        <property type="protein sequence ID" value="AGN75679"/>
        <property type="gene ID" value="TPANIC_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0488"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.522"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="VMSEITH"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="458"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="559"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="845" mass="91517" checksum="146E75B255523063" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>O83517</accession>
    <name>Y504_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0504</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0504</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71317">
        <property type="entry name" value="D71317"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83517"/>
    <dbReference type="IntAct" id="O83517">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65493">
        <property type="protein sequence ID" value="AAC65493"/>
        <property type="gene ID" value="TP_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0504"/>
    <dbReference type="HOGENOM" id="CLU_3190275_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202268" description="Uncharacterized protein TP_0504">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="46" mass="5038" checksum="5BFA08088568ACC3" modified="1998-11-01" version="1">MEVTPLETGRARSHQKASTAAQPHAADEKMTGSTARRYLSQDHQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83518</accession>
    <name>O83518_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexokinase (Hxk)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71317">
        <property type="entry name" value="E71317"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881954.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83518">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0505"/>
    <dbReference type="EnsemblBacteria" id="AAC65489">
        <property type="protein sequence ID" value="AAC65489"/>
        <property type="gene ID" value="TP_0505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75694">
        <property type="protein sequence ID" value="AGN75694"/>
        <property type="gene ID" value="TPANIC_0505"/>
    </dbReference>
    <dbReference type="GeneID" id="57879025"/>
    <dbReference type="KEGG" id="tpa:TP_0505"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.500"/>
    <dbReference type="eggNOG" id="COG5026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_3_12"/>
    <dbReference type="OMA" id="IAINCEW"/>
    <dbReference type="OrthoDB" id="926142at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:cellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="PTHR19443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase_1" evidence="8">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase_2" evidence="9">
        <location>
            <begin position="219"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="444" mass="47845" checksum="5ACC3E1100D4B07E" modified="1998-11-01" version="1">MDQHTRTRDLVSAFFGRFHFDVQGPSVRTVVDVLRADMVRGLEEEAQLPPRMGSALAMIPTWVAPPRVSPCNRRVIVIDAGGTNFRSCLVRFGDSGTPHIENLEKRPMPGTTREYSRTEFFGEIADNLARLKGAADCIGFCFSYPIRIRPDGDGEVIQFAKEIKAAEVIGTCVGAGLTEALSARNWPELRSLKMLNDATSALLAGFFAAPEGCSFSSYVGFILGTGMNSAYLEPDPIPKIPAHHTPQVVVCESGKSNKVPRSVFDELFTQTTAEPDIAHLEKMSSGTYLGPLASVVVRLAAQEGLFSHAVHAALSTVSFTLVDMDRFLFAPSVSTTTLGALLAPGTDTDREILFLLLDAVVARAARIAAGVIAASVLKSGAGYDPLRPVCVLAEGTTFQRTYRLRTRVTSHLQAFLTEERGVYFDIISLENAVTLGSALGGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83526</accession>
    <name>O83526_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">K+ transport protein (TrkA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71314">
        <property type="entry name" value="H71314"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881962.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83526"/>
    <dbReference type="IntAct" id="O83526">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0513"/>
    <dbReference type="EnsemblBacteria" id="AAC65501">
        <property type="protein sequence ID" value="AAC65501"/>
        <property type="gene ID" value="TP_0513"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75702">
        <property type="protein sequence ID" value="AGN75702"/>
        <property type="gene ID" value="TPANIC_0513"/>
    </dbReference>
    <dbReference type="GeneID" id="57879036"/>
    <dbReference type="KEGG" id="tpa:TP_0513"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.508"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_0_3_12"/>
    <dbReference type="OMA" id="IACQVAY"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="232"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="383"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="466" mass="49642" checksum="7D266ED62B7F49D0" modified="1998-11-01" version="1">MRVIVVGCGTNGRELTRRLSARGHQVTLVAAAHEPVPRKIPAGAQALVRHQKDHRATLGEAGIAKAQAFVAVTEVDELNIVLCGIAADLNAGVIKIAQTHDDHYAHAVCRESRCIFGIDFLISADKEAMRAVVSTVEQGAISDVIPLKNAPYEIARFPIAKGSGLDGITLSDMRRLVKISFVAVAFEVRGRSVIPSGETMLASGMRLSVLCAPEHMGRFYELAGFKIHPVKKIALIGMSAVGTLVAQDVAEKCKPHFFSSAFSLSPRERASLVLVDKSETATQAVCAQFPHVTAYHGDVTDEAFFAEITPDTFDLVITTTNNYELNMITAAYMKTLGVPRAVALVHSSLMEDIAGKIGIDVAVSYQDVVVDAIMSHLAGSHVTGIHTIGDGSLEIVEFAISAQSPLVGKRLKDIAVHGSFLVLLISTVRGSFIPSGDTVLLEGSVLMFIVQSAQSEKIVALLGGTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83534</accession>
    <name>Y522_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0522</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0522</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71315">
        <property type="entry name" value="H71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881970.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83534"/>
    <dbReference type="IntAct" id="O83534">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0522"/>
    <dbReference type="EnsemblBacteria" id="AAC65511">
        <property type="protein sequence ID" value="AAC65511"/>
        <property type="gene ID" value="TP_0522"/>
    </dbReference>
    <dbReference type="GeneID" id="57879045"/>
    <dbReference type="KEGG" id="tpa:TP_0522"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129914_0_0_12"/>
    <dbReference type="OMA" id="FFLVIHI"/>
    <dbReference type="OrthoDB" id="2061122at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202269" description="Uncharacterized protein TP_0522">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="159" mass="17810" checksum="A922297C1E507CF1" modified="1998-11-01" version="1">MTISTLDLILGIIMGIVTVRATMRGFVDEFFSKASILCAAVVAILCHKRLVPLTRVLLGHSILLPCITFLITFMGVYCVMLFLRSRMRTYATRDLISGFNQVFGFFFGIIEGSVLLTVILLLLHVQPFVSVSHMLHESVINTVLSPLVLDGVRYMRLKM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83553</accession>
    <name>PFP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="1">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pfp</name>
        <name type="ordered locus">TP_0542</name>
        <name type="ORF">TPANIC_0542</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2001" name="FEMS Microbiol. Lett." volume="194" first="257" last="260">
            <title>Biochemical characterization of an active pyrophosphate-dependent phosphofructokinase from Treponema pallidum.</title>
            <authorList>
                <person name="Roberson R.S."/>
                <person name="Ronimus R.S."/>
                <person name="Gephard S."/>
                <person name="Morgan H.W."/>
            </authorList>
            <dbReference type="PubMed" id="11164318"/>
            <dbReference type="DOI" id="10.1111/j.1574-6968.2001.tb09479.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1 2">Non-allosteric.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">1.39 mM for phosphate</KM>
            <KM evidence="2">0.042 mM for diphosphate</KM>
            <KM evidence="2">0.529 mM for fructose 6-phosphate</KM>
            <KM evidence="2">0.267 mM for fructose 1,6-bisphosphate</KM>
            <Vmax evidence="2">141.0 umol/min/mg enzyme for the forward reaction</Vmax>
            <Vmax evidence="2">42.4 umol/min/mg enzyme for the reverse reaction</Vmax>
        </kinetics>
        <phDependence>
            <text evidence="2">Optimum pH is 8.0 for both the forward and reverse reactions.</text>
        </phDependence>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71312">
        <property type="entry name" value="C71312"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881989.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83553"/>
    <dbReference type="SMR" id="O83553"/>
    <dbReference type="IntAct" id="O83553">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0542"/>
    <dbReference type="PRIDE" id="O83553"/>
    <dbReference type="EnsemblBacteria" id="AAC65526">
        <property type="protein sequence ID" value="AAC65526"/>
        <property type="gene ID" value="TP_0542"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75729">
        <property type="protein sequence ID" value="AGN75729"/>
        <property type="gene ID" value="TPANIC_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0542"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0542"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.538"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022288_0_1_12"/>
    <dbReference type="OMA" id="SAKKYWH"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01980">
        <property type="entry name" value="Phosphofructokinase_II_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011183">
        <property type="entry name" value="PfpB_PPi_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005677">
        <property type="entry name" value="PPi_PFK_PfpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02477">
        <property type="entry name" value="PFKA_PPi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000429711" description="Pyrophosphate--fructose 6-phosphate 1-phosphotransferase">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11164318"/>
        </source>
    </evidence>
    <sequence length="573" mass="62427" checksum="3A9A95B01CBC134E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83565</accession>
    <name>O83565_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase (Gph-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71309">
        <property type="entry name" value="F71309"/>
    </dbReference>
    <dbReference type="IntAct" id="O83565">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0554"/>
    <dbReference type="EnsemblBacteria" id="AAC26558">
        <property type="protein sequence ID" value="AAC26558"/>
        <property type="gene ID" value="TP_0554"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75741">
        <property type="protein sequence ID" value="AGN75741"/>
        <property type="gene ID" value="TPANIC_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0554"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.551"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_12"/>
    <dbReference type="OMA" id="YLCGKFG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC26558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24577" checksum="1EFC03734C5BF980" modified="1998-11-01" version="1">MRPMTRACIFDLDGTLTNTLGTIAYFVNMQAAHYHLPPIPSEKFALFLGDGSRALIQRVLAHYGAAAQTISEDEFLQRYCLAYEADFLQRCTVYPGVPEMLVELKRRRIELAILSNKPHSIAQKVASAFFGDNVFSVVLGQREGVPVKPDPAGLFEILRTLNVETAEALFVGDTAVDIRTASAAQVRSVGVLWGFRDETELSQAQAHVLIRTPAELLQHLSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O83583</accession>
    <name>Y573_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0573</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0573</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71309">
        <property type="entry name" value="C71309"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83583"/>
    <dbReference type="IntAct" id="O83583">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65550">
        <property type="protein sequence ID" value="AAC65550"/>
        <property type="gene ID" value="TP_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0573"/>
    <dbReference type="HOGENOM" id="CLU_3405987_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202276" description="Uncharacterized protein TP_0573">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <sequence length="30" mass="3380" checksum="C0B2640A4B30E33C" modified="1998-11-01" version="1">MQTFSLLVAYKIFTDGTETKRVHASKAKHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83592</accession>
    <name>Y583_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0583</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0583</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71307">
        <property type="entry name" value="E71307"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83592"/>
    <dbReference type="IntAct" id="O83592">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65561">
        <property type="protein sequence ID" value="AAC65561"/>
        <property type="gene ID" value="TP_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0583"/>
    <dbReference type="HOGENOM" id="CLU_3278193_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202279" description="Uncharacterized protein TP_0583">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <sequence length="41" mass="4514" checksum="570D9C0C3D582FC6" modified="1998-11-01" version="1">MRSSIAPTAPAACSSKRWYPSVCEPDVRNQKNWGHPITPCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83604</accession>
    <name>KAD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <shortName evidence="1">AK</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk</name>
        <name type="ordered locus">TP_0595</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71306">
        <property type="entry name" value="D71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882041.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83604"/>
    <dbReference type="SMR" id="O83604"/>
    <dbReference type="STRING" id="243276.TPANIC_0595"/>
    <dbReference type="EnsemblBacteria" id="AAC65567">
        <property type="protein sequence ID" value="AAC65567"/>
        <property type="gene ID" value="TP_0595"/>
    </dbReference>
    <dbReference type="GeneID" id="57879119"/>
    <dbReference type="KEGG" id="tpa:TP_0595"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_12"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000158878" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <sequence length="211" mass="22933" checksum="E33CD7B1B7375DF3" modified="1998-11-01" version="1">MRFVFLGPPGAGKGTLAGEISGRCGVVHISTGGILRAAIQKQTALGKKVQKVVEVGGLVDDQTVTELVRERVSHEDVVSGFILDGFPRTVTQARCLEDIVPIDYAVSIVVPDDVLVARLTGRRVCSACGSSYHVLFAQPKREGVCDRCRGVLVVREDDKMSAILQRLTAYRAQAEPIVHFYSERGKLVSLNGAPPISDVVLEFQERFAQSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83616</accession>
    <name>Y607_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0607</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0607</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71305">
        <property type="entry name" value="A71305"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83616"/>
    <dbReference type="IntAct" id="O83616">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65583">
        <property type="protein sequence ID" value="AAC65583"/>
        <property type="gene ID" value="TP_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0607"/>
    <dbReference type="HOGENOM" id="CLU_3190279_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202286" description="Uncharacterized protein TP_0607">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <sequence length="48" mass="5451" checksum="6D3CBF1E3DA4E2C8" modified="1998-11-01" version="1">MTVCEGTRFSVLSRISPARVRVVKERRMRASALSVEEWYGSGDYQKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83629</accession>
    <name>O83629_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tpr protein I (TprI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71301">
        <property type="entry name" value="E71301"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882066.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83629">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0620"/>
    <dbReference type="EnsemblBacteria" id="AAC65594">
        <property type="protein sequence ID" value="AAC65594"/>
        <property type="gene ID" value="TP_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0620"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.661"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="MWSERYF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004160545" evidence="1">
        <location>
            <begin position="23"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_N" evidence="2">
        <location>
            <begin position="84"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="3">
        <location>
            <begin position="411"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="609" mass="66511" checksum="AB9A0DFE27859235" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83630</accession>
    <name>O83630_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71301">
        <property type="entry name" value="G71301"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882068.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83630">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0622"/>
    <dbReference type="EnsemblBacteria" id="AAC65603">
        <property type="protein sequence ID" value="AAC65603"/>
        <property type="gene ID" value="TP_0622"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75803">
        <property type="protein sequence ID" value="AGN75803"/>
        <property type="gene ID" value="TPANIC_0622"/>
    </dbReference>
    <dbReference type="GeneID" id="57879145"/>
    <dbReference type="KEGG" id="tpa:TP_0622"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.614"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032129_0_0_12"/>
    <dbReference type="OMA" id="ERRAVYY"/>
    <dbReference type="OrthoDB" id="1131043at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="544"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="593" mass="66777" checksum="0C47CE0F834B842F" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83631</accession>
    <name>O83631_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound lytic murein transglycosylase D (DniR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71301">
        <property type="entry name" value="H71301"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0623"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65596">
        <property type="protein sequence ID" value="AAC65596"/>
        <property type="gene ID" value="TP_0623"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75804">
        <property type="protein sequence ID" value="AGN75804"/>
        <property type="gene ID" value="TPANIC_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0623"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.615"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020121_0_0_12"/>
    <dbReference type="OMA" id="GFWQFKK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="605"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="732"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="779" mass="84831" checksum="CF53459F1BE76D7D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83637</accession>
    <name>Y629_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0629</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0629</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71300">
        <property type="entry name" value="C71300"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83637"/>
    <dbReference type="IntAct" id="O83637">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0629"/>
    <dbReference type="EnsemblBacteria" id="AAC65612">
        <property type="protein sequence ID" value="AAC65612"/>
        <property type="gene ID" value="TP_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0629"/>
    <dbReference type="eggNOG" id="ENOG5031C7C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1030316_0_0_12"/>
    <dbReference type="OMA" id="KRFHFYR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202292" description="Uncharacterized protein TP_0629">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <sequence length="274" mass="31272" checksum="89ACAAA4D859546D" modified="1998-11-01" version="1">MDLGMTMAGFLRGLWCVVGTSVCAQTLQEAPAHFLLEGTDFAARVLRMSISARNVPSYWFEEGVWSEAPSASSRLPAKNKSTPGVPRRVTRALPRVKPDVFVFGNEHETVFWGQLNTIEHARYVVHRAVHPLDAHAHERYYEPLLKRFHFYCLEGRTPITSVSLCLFALDVSTRLIWAYALPSQVEMVWGTCIPRAWIPLEMHSHVRARYPKAKFYQFDPIGFVDSEGKVVLYPWALEQHAQRPQDFLVYEPQQGDWEQVASQTGPGHSPYRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83660</accession>
    <name>O83660_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter, permease protein (PotC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0654</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71296">
        <property type="entry name" value="G71296"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882099.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83660">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0654"/>
    <dbReference type="EnsemblBacteria" id="AAC65629">
        <property type="protein sequence ID" value="AAC65629"/>
        <property type="gene ID" value="TP_0654"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75833">
        <property type="protein sequence ID" value="AGN75833"/>
        <property type="gene ID" value="TPANIC_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0654"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.647"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_0_12"/>
    <dbReference type="OMA" id="FPMFVWG"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="272" mass="29951" checksum="EA33557FEB5C4ED1" modified="1998-11-01" version="1">MPNCRLIHTRARTPLRCSFSAVLLAAVVSFLFLPLAVIALFSFNKDKSLIWTGFSLRWYTELFFYSEKLWSSFLNSVLIASVSALVATIVGTAAAIAIRWYRFSGRLYAQVMSLLPMLLPEVITGMAMLVFFSLVRLPLGRASIITAHITFCLPFVLLLILTRIDTFDLSLIEAAQDLGANEWQALGKIVIPAIMPGILSGFLLSVTLSLEDFVITFFVAGPGSTTLPLYVFSMIRYGVSPIINALSLIMMAGIVGVAYLLRNSLKTIVHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83689</accession>
    <name>O83689_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71292">
        <property type="entry name" value="H71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882136.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83689"/>
    <dbReference type="IntAct" id="O83689">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0691"/>
    <dbReference type="EnsemblBacteria" id="AAC65659">
        <property type="protein sequence ID" value="AAC65659"/>
        <property type="gene ID" value="TP_0691"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75869">
        <property type="protein sequence ID" value="AGN75869"/>
        <property type="gene ID" value="TPANIC_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0691"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.683"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_0_12"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="252" mass="29230" checksum="BA8069D78D95614D" modified="1998-11-01" version="1">MWMDESPVPVQEFKLSQFEGPLDLLLFLIKKNELSIYDIPICEITAQYLQYVDQTVSPDLRGLTEFYAMAAVLLYIKSCMLLPMELDLDGEDIEDPRQSLVEHLIEYQKYKQLCKLMELYECEDMWCVERKKTQHLFLSPAEVPLLHGDVRDLLMLFIRLVRKTPQWIMDLYEEVSVNEKLTLLSELLGVRGRCVFTELIKQPSRADVVCAFVAILEAAKTHLVHISQPEFFGPITLYAREVSPKVQDVCHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83706</accession>
    <name>Y708_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0708</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0708</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71289">
        <property type="entry name" value="H71289"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882153.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83706"/>
    <dbReference type="IntAct" id="O83706">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0708"/>
    <dbReference type="EnsemblBacteria" id="AAC65695">
        <property type="protein sequence ID" value="AAC65695"/>
        <property type="gene ID" value="TP_0708"/>
    </dbReference>
    <dbReference type="GeneID" id="57879233"/>
    <dbReference type="KEGG" id="tpa:TP_0708"/>
    <dbReference type="HOGENOM" id="CLU_1562198_0_0_12"/>
    <dbReference type="OMA" id="FLKVPAI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202309" description="Uncharacterized protein TP_0708">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="171" mass="17961" checksum="8C97AE403F9A3384" modified="1998-11-01" version="1">MDVQERRFSCAAVGASLKVPAIAAGAAFFLSIATAAVARNARVYVSVARATVLALGAGVTAYALRALLAYVVPDLLVQEDGKMPIPHVDLTLDDVVEPSFASPGGDVVQETDDSFDSLIPTGELGELGYSFSPSTPSFEDKTSDLVGDVLTDLPETKRMARAIRTVLSQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>O83707</accession>
    <name>O83707_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-28 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71290">
        <property type="entry name" value="A71290"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882154.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83707">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0709"/>
    <dbReference type="EnsemblBacteria" id="AAC65675">
        <property type="protein sequence ID" value="AAC65675"/>
        <property type="gene ID" value="TP_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0709"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.754"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_1_12"/>
    <dbReference type="OMA" id="IKFETYA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="262" mass="29928" checksum="B0C9F93865A4E99D" modified="1998-11-01" version="1">MGNTAFEQQSEEELWLEYRRTRSAKIREYFVVQYAPLVKYVASKIAVGKPGNVEFDDLVSYGIFGLFDAIDKYDPEKNIRFNTYAVTRIRGAIFDELRSIDWVPRSVRQQTRQIEEAIADLEARLGRXATDTEIACALNIELEEYHQLLLKVSGTSVISLADSKFGGDERDHVSVGDSIEAPASLNPDVIVEREEIKRIIAEAIRELSQREQQVLILYYYEEMTLKEIGKVLKVTESRISQIHTSANLKLKAKLTNIKKGIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83710</accession>
    <accession>Q56337</accession>
    <name>FLHB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">flhB</name>
        <name type="ordered locus">TP_0715</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Gene" volume="166" first="57" last="64">
            <title>Identification and sequences of the Treponema pallidum fliM', fliY, fliP, fliQ, fliR and flhB' genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="8529894"/>
            <dbReference type="DOI" id="10.1016/0378-1119(95)00583-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71290">
        <property type="entry name" value="G71290"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882160.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83710"/>
    <dbReference type="SMR" id="O83710"/>
    <dbReference type="IntAct" id="O83710">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0715"/>
    <dbReference type="PRIDE" id="O83710"/>
    <dbReference type="EnsemblBacteria" id="AAC65681">
        <property type="protein sequence ID" value="AAC65681"/>
        <property type="gene ID" value="TP_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0715"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_1_2_12"/>
    <dbReference type="OMA" id="DEYKQQE"/>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000180954" description="Flagellar biosynthetic protein FlhB">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB00549." evidence="3" ref="1">
        <original>ALVLIFTKLDKFKTHAQRKR</original>
        <variation>CFSADFYQAG</variation>
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="376" mass="43039" checksum="FEA32E2E8B269540" modified="1998-11-01" version="1">MIEQEGTFPLPLFIIDLQWFAAEDEGRSEDPTETKLRKAREEGRVPKSQDLNGAFVMLFTSTSLFLLAPFILRECIGVLRFFFTRATTASIQNTGWFFVFVRYFMKLALPISFVALVSGVAANIVQNKTVLFSVKSIRPQFKKISPDVIRFFKRSFFSTEGLFNLLKSLIKITAIFFVSYFTIRNDLFMFVSLLGVSLTQSIFYITSLAGKVLLEVSLLLVVFSLPDYFFQRRQFIDSLKMSRQEVKEELKEQEGDPLVRSYVRKQMQSLVRESARNTTDADVVITNPTHFAVAVQYEPAYMTAPTVVAKGSDGTAYRIKRLAKEAGILIEENKPLARALYTQVAIGREVPYEYFNALVLIFTKLDKFKTHAQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83755</accession>
    <name>O83755_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71282">
        <property type="entry name" value="A71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882221.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0776"/>
    <dbReference type="EnsemblBacteria" id="AAC65745">
        <property type="protein sequence ID" value="AAC65745"/>
        <property type="gene ID" value="TP_0776"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75949">
        <property type="protein sequence ID" value="AGN75949"/>
        <property type="gene ID" value="TPANIC_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0776"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.763"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_0_0_12"/>
    <dbReference type="OMA" id="LWPTRCA"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="258" mass="28894" checksum="1B4515FC00080A06" modified="1998-11-01" version="1">MILFSRARLWARDGVARAYVSFLGPRRCVFCASRCTGTVPLCCSCVQDRLYARAHDFLEHPEDFCSRCAKPLVSARALCVSCRALRESGETPALWRVFSLLPYLGVGRPLMSLWKTQQERNFDALFSRIAGCFLRTARERSFVTASTELVPVPPRPCKMAERGWDQVEDVSRRLELAGFTVNRALVRVEGRFAQKTLSRAARVENLAGSIELGAHARVPRDALIIDDVVTTYATMDACARVLRSSGSERVQGFSFFFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83756</accession>
    <name>Y777_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0777</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0777</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71282">
        <property type="entry name" value="B71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882222.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83756"/>
    <dbReference type="IntAct" id="O83756">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0777"/>
    <dbReference type="EnsemblBacteria" id="AAC65750">
        <property type="protein sequence ID" value="AAC65750"/>
        <property type="gene ID" value="TP_0777"/>
    </dbReference>
    <dbReference type="GeneID" id="57879299"/>
    <dbReference type="KEGG" id="tpa:TP_0777"/>
    <dbReference type="eggNOG" id="ENOG5031CR7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686730_0_0_12"/>
    <dbReference type="OMA" id="HRDICEP"/>
    <dbReference type="OrthoDB" id="1905396at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202321" description="Uncharacterized protein TP_0777">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <sequence length="74" mass="9018" checksum="299EB9E2CEC22DE5" modified="1998-11-01" version="1">MKTLQCDICRKEVDNSLPERLYWTFREYDVCEDCKESIEDKLRPIIRTHQPYSQGWYENQFMGMVQRGVSNRRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83766</accession>
    <name>Y787_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0787</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0787</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71280">
        <property type="entry name" value="B71280"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882232.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83766"/>
    <dbReference type="SMR" id="O83766"/>
    <dbReference type="IntAct" id="O83766">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65762">
        <property type="protein sequence ID" value="AAC65762"/>
        <property type="gene ID" value="TP_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0787"/>
    <dbReference type="HOGENOM" id="CLU_2037037_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202325" description="Uncharacterized protein TP_0787">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="139" mass="15068" checksum="C31A243C6D2F0C22" modified="1998-11-01" version="1">MHCPLLRHTVVIEWAAPSMVGSAPMGRDSPAGMREAVYFLHRMVVCLGVLLCAASLLYVFGNFSHFLDKSQFIILRSCVGCSVLLVVACLCAGSFELYFFLTRSDAPYGRLLCITVVALLFGMGALVFNTVVLIVAKGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83797</accession>
    <name>Y825_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0825</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0825</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71276">
        <property type="entry name" value="C71276"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83797"/>
    <dbReference type="STRING" id="243276.TPANIC_0825"/>
    <dbReference type="EnsemblBacteria" id="AAC65799">
        <property type="protein sequence ID" value="AAC65799"/>
        <property type="gene ID" value="TP_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0825"/>
    <dbReference type="HOGENOM" id="CLU_2921416_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202335" description="Uncharacterized protein TP_0825">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <sequence length="61" mass="7260" checksum="9AB19F958C9CDC9D" modified="1998-11-01" version="1">MNSMHLHAVRYIRVRLQRMRQMAAIQRKERGGPACSRQAPGDRIRFNRRTRCLESEHRAIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83806</accession>
    <name>SYY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">TP_0834</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65798" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65798.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71277">
        <property type="entry name" value="D71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342602.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83806"/>
    <dbReference type="SMR" id="O83806"/>
    <dbReference type="IntAct" id="O83806">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0834"/>
    <dbReference type="EnsemblBacteria" id="AAC65798">
        <property type="protein sequence ID" value="AAC65798"/>
        <property type="gene ID" value="TP_0834"/>
    </dbReference>
    <dbReference type="GeneID" id="57879351"/>
    <dbReference type="KEGG" id="tpa:TP_0834"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_12"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000055667" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="409" mass="45079" checksum="384A025D8C3106B8" modified="2006-05-16" version="2">MNPALARLQARGFIRQCTDLSALSARMDAGPLTFYVGVDPTGSSLHVGHMLPMFALKHLCDAGHRGCVLIGGGTARIGDPSGKTSMRKMLDYATLDAYAGAIVAQLDHFLSFDHRHVFYVNNRDWLAHLNYIDFLREVGAHFSVNKMLTYEAYKKRLETGLSFLEFNYQLLQSYDFLTLSDRYAVELQIGGDDQWGNIVAGADLVRRVRGKTVHGLTFPLITRADGQKMGKTEQGALFLDPALVSPYDFFQYWRNTPDEDVRRFLLLFTFLSVRDVEAILTQGINCAKELLAYEVTRLMHGTAVAQVALQGARAAFGGCGDKCALPTFELTQCTLQVGIKVTDLFVQVGLCTTKSDARRLIAQGGAFVGLQRVADIGAVIDQSALDLDGTVIVRAGKKRVVRIVTDVLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83811</accession>
    <name>Y839_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0839</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0839</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71275">
        <property type="entry name" value="D71275"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882283.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83811"/>
    <dbReference type="STRING" id="243276.TPANIC_0839"/>
    <dbReference type="EnsemblBacteria" id="AAC65809">
        <property type="protein sequence ID" value="AAC65809"/>
        <property type="gene ID" value="TP_0839"/>
    </dbReference>
    <dbReference type="GeneID" id="57879356"/>
    <dbReference type="KEGG" id="tpa:TP_0839"/>
    <dbReference type="HOGENOM" id="CLU_828859_0_0_12"/>
    <dbReference type="OMA" id="QAYPHTI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014264" description="Uncharacterized lipoprotein TP_0839">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="335" mass="37365" checksum="2F4C5FE154DAB869" modified="1998-11-01" version="1" precursor="true">MDKKARAHTVIVCLVGALSLACAYLLGGSMKYLRGDVSRFWTSSRMQRHPAHSSQPVVRTFTDADGYTCLDQAHPHTIVIDATRVRVSVQVCAQRRSLAYKVVKNSVYDPLSIHLDPTMLVLRRGKKTVRESTPPADSPGVMQSALNVRDTLRDWFYTFWKNVWGSRWGHSVVPIEAIICVPAQHNVHNLKVRVKDSSLRLEGIEVRFADVYAHASELKLNGVRTDRTLLHTTDGDTQCSRCVLSDAHLYTDRGTLSFDGTLQGNSEIGTRTGTVVARFTERQSYYALSVFSGHGAVYINDQRVRKTLGTCLSTGGSAQLCVRNERGVLHVYFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83815</accession>
    <name>O83815_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71273">
        <property type="entry name" value="C71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882287.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83815">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0843"/>
    <dbReference type="EnsemblBacteria" id="AAC65811">
        <property type="protein sequence ID" value="AAC65811"/>
        <property type="gene ID" value="TP_0843"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76013">
        <property type="protein sequence ID" value="AGN76013"/>
        <property type="gene ID" value="TPANIC_0843"/>
    </dbReference>
    <dbReference type="GeneID" id="57879360"/>
    <dbReference type="KEGG" id="tpa:TP_0843"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.830"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000924_0_0_12"/>
    <dbReference type="OMA" id="REDWMDC"/>
    <dbReference type="OrthoDB" id="1322159at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31526" checksum="84860F47D713B076" modified="1998-11-01" version="1">MHFSMCPDTMASPWKVWPLVEDYYRVLGVSHRASTPEIKCAFRKKAKALHPDLVSHTAELECEAVARERALRRILTAYEVLSDPGRRAKFDLLYARFCARPAPAGFDYRVYLRAQGTLCAMVELILFDLFHGFECDAVRAYLSLKCRPEGFNLATHLTREDFMDCGFVLAEELHVRGECYECFTLLQDIVFEELRCAYFRHFFPEVLKLAEHIALGTASVRGRNGKSCVYCARAHACLPAQEIVTFYACLVEYYERTGDRRRARGYAQKMDSVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83841</accession>
    <name>Y871_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0871</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0871</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71270">
        <property type="entry name" value="E71270"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83841"/>
    <dbReference type="STRING" id="243276.TPANIC_0871"/>
    <dbReference type="EnsemblBacteria" id="AAC65846">
        <property type="protein sequence ID" value="AAC65846"/>
        <property type="gene ID" value="TP_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0871"/>
    <dbReference type="HOGENOM" id="CLU_3067334_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202343" description="Uncharacterized protein TP_0871">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="53" mass="5998" checksum="F238BDAFD5C6D6D7" modified="1998-11-01" version="1">MSAYRYANLTNTKYIPSVYAVMATAGCDDRKIKRKEKGKRHAAPLSLMGVHKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83843</accession>
    <name>Y873_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0873</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0873</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71270">
        <property type="entry name" value="G71270"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882316.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83843"/>
    <dbReference type="SMR" id="O83843"/>
    <dbReference type="IntAct" id="O83843">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0873"/>
    <dbReference type="EnsemblBacteria" id="AAC65847">
        <property type="protein sequence ID" value="AAC65847"/>
        <property type="gene ID" value="TP_0873"/>
    </dbReference>
    <dbReference type="GeneID" id="57879387"/>
    <dbReference type="KEGG" id="tpa:TP_0873"/>
    <dbReference type="eggNOG" id="ENOG5033BU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383650_0_0_12"/>
    <dbReference type="OMA" id="QMEINIE"/>
    <dbReference type="OrthoDB" id="1289611at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202344" description="Uncharacterized protein TP_0873">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <sequence length="200" mass="21702" checksum="A915ABF326FC57A5" modified="1998-11-01" version="1">MDITINGHTLQYVIEHEKTIGEVLGAIEAACKKEKQTVSAVTVNGRELSANELDTLFCQSLDTDVTLNLTTLSGGDVRALLREISTTLLARTAALQEIAVNMHSGNLAESYAMVSDFSALLKSLYHCFTLSDIADLDHGLRIKGKALHDYQREISPLLKGLLEAMEEGDSVAVGDIAEYELAPVVRDLSDGILHMDMGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83850</accession>
    <name>O83850_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane spanning protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71271">
        <property type="entry name" value="F71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882323.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83850">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0880"/>
    <dbReference type="EnsemblBacteria" id="AAC65842">
        <property type="protein sequence ID" value="AAC65842"/>
        <property type="gene ID" value="TP_0880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76049">
        <property type="protein sequence ID" value="AGN76049"/>
        <property type="gene ID" value="TPANIC_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="57879394"/>
    <dbReference type="KEGG" id="tpa:TP_0880"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.864"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081003_0_0_12"/>
    <dbReference type="OMA" id="KFLAAWV"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26999" checksum="C57ADC6D817B65AE" modified="1998-11-01" version="1">MQCKQFFTLYKKELRSLLTSPVTYVCHVLLHLGLTIPFIGVNFWLNAGISELQSFFLNAPLLFCIIIPLLTMHVWSHERKSGTDTLLFSFPIAERTIVLTKYLSLLSVYGGMIVVSTAIPLSIFSLGYFDYAPCALAYVTLVLFGAALLSLSCAVASYVSYAAVGFVLNFTLAVMALLVHIPARVFISHRYIRACVSWVSFVYHFESAARGIFDLSDFAFYIFVAIAGIELQCLIVRVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83853</accession>
    <name>O83853_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71268">
        <property type="entry name" value="H71268"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0883"/>
    <dbReference type="EnsemblBacteria" id="AAC26573">
        <property type="protein sequence ID" value="AAC26573"/>
        <property type="gene ID" value="TP_0883"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76052">
        <property type="protein sequence ID" value="AGN76052"/>
        <property type="gene ID" value="TPANIC_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0883"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.867"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_2_12"/>
    <dbReference type="OMA" id="WFTSKLA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC26573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="365" mass="42123" checksum="2D5A1C6239F92CB8" modified="1998-11-01" version="1">MLDMFLPIFFLVLVCASMILDAIDILVNLTQFISNGYRFSSLVKIWYVSIPHYVLLCCPLSVLFAATYTVRILYVQNEFLAIHFGGLSFFSIVGPWFGFMCFLAIGIFAFDNSVVVVSQSKKDEIIARTVSYAQGNSENDVVASSFDGKIISIAGAYHRGQKVLVDMLVIMKNSNGTIQKLIEAHTAHWQKDRWVLIKPVVYTITHEMKLMVSEYLDSFELREPLELFDHQDFLTKGMSIQKIKETLHTLKYASKPHRELSIRFYKKFYFPLTMCIMLCLSFLTGSFLKKRSLIMYIFCSVVLASAYYVVEMTSIVCAREEYFSPFWGVFFPVLTFLFLIFYVWCAGFMQERQYRASSLRQSVCL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83860</accession>
    <name>RBFA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">TP_0890</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71269">
        <property type="entry name" value="G71269"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882333.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83860"/>
    <dbReference type="SMR" id="O83860"/>
    <dbReference type="STRING" id="243276.TPANIC_0890"/>
    <dbReference type="EnsemblBacteria" id="AAC26580">
        <property type="protein sequence ID" value="AAC26580"/>
        <property type="gene ID" value="TP_0890"/>
    </dbReference>
    <dbReference type="GeneID" id="57879404"/>
    <dbReference type="KEGG" id="tpa:TP_0890"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_6_5_12"/>
    <dbReference type="OMA" id="CSLSINH"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000102761" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <sequence length="126" mass="14128" checksum="D4B19B9861BBD2B3" modified="1998-11-01" version="1">MKQVSQLRVRKLGEHIRAEIAQLIMLGKIKDPRVSPFLSVNWVDVSGGMVCARVYVSSFMGKYKTKQGVQGLESAAGFIRSVLAKKLRLRQCPRLSFVYDESVRDGFSLSRKIDRLESGGVQTEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83867</accession>
    <accession>Q9L8S8</accession>
    <name>O83867_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein K (TprK)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65852.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71266">
        <property type="entry name" value="F71266"/>
    </dbReference>
    <dbReference type="IntAct" id="O83867">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0897"/>
    <dbReference type="EnsemblBacteria" id="AAC65852">
        <property type="protein sequence ID" value="AAC65852"/>
        <property type="gene ID" value="TP_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0897"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="112"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="319"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65852.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="505" mass="55466" checksum="B53D6475508DED9E" modified="2014-04-16" version="3">MIDPSATSRYGSPRLVSNGFRHRRKVVYQRVGHRRFSLIFFFVVVLGRSPRLWAQVSFTPDIEGYAELAWGIAXEDGXAGNLKHGFKTTTDFKIVFPIVAKKDFKYRGEGNVYAEINVKALKLSLESNGGAKFDTKGSAKTIEATLHCYGAYLTIGKNPDFKSTFAVLWEPWTANGDYKSKGDKPVYEPGFEGAGGKLGYKQTDIAGTGLTFDIAFKFASNTDWEGKDSKGNVPAGVTPSKYGLGGDILFGWERTREDGVQEYIKVELTGNSTLSSDYAQARALAAGAKVSMKLWGLCALAATDVGHKKNGAQGTVGADALLTLGYRWFSAGGYFASXASNVFGGVFLNMAMREHDCAAYIKLETKGSDPDTSFLEGLDLGVDVRTYMPVHYKVLKALPPAIXFPVYGKVWGSYRHDMGEYGWVKVYANLYGGTNKKATPPAAPATKWKAGYCGYYECGVVVSPLEKVEIRLSWEQGKLQENSNVVIEKNVTERWQFVGACRLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83868</accession>
    <name>O83868_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TP_0898</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71266">
        <property type="entry name" value="G71266"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882341.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83868">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0898"/>
    <dbReference type="EnsemblBacteria" id="AAC65853">
        <property type="protein sequence ID" value="AAC65853"/>
        <property type="gene ID" value="TP_0898"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76067">
        <property type="protein sequence ID" value="AGN76067"/>
        <property type="gene ID" value="TPANIC_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0898"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.883"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001114_1_3_12"/>
    <dbReference type="OMA" id="QSFIVQA"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="9"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="566"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAC65853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137096" checksum="DCCCDA3B1F267597" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83887</accession>
    <name>O83887_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71265">
        <property type="entry name" value="B71265"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882360.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83887">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0917"/>
    <dbReference type="EnsemblBacteria" id="AAC65873">
        <property type="protein sequence ID" value="AAC65873"/>
        <property type="gene ID" value="TP_0917"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76084">
        <property type="protein sequence ID" value="AGN76084"/>
        <property type="gene ID" value="TPANIC_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0917"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.900"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_12"/>
    <dbReference type="OMA" id="TMTVAVR"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="449" mass="49695" checksum="F5BF7E18D10A97CF" modified="1998-11-01" version="1">MNENFEKIQTLLEHKRYVPLIANLNEMNEVDVAHVLDMQSPAQALLLFRMLPKNLAANVFAQLSSSKQSAFLATITDRELAPILAELAMDDIVDLVEEMPANAVKRILAQTGETERQVINQLLKYPEDSAGSLMTTEYVDLEKQMTVHDALCCIRETGLKKETVYTCYVIDQNRFLHGVISLKKLVLSQGDLLIENLCERDCIFVHTHDDQEAVAAVFKKYGFLALPVVDTERRLIGIITVDDIMDVMQQEVTEDFQIMAAMQPSDEAYLETEVFTLVKHRIGWLLLLMVSETFTGNLIAGYEDLLVTATALTTFIPMLMDTGGNSGSQSSTLIIRGLATGEIQLHDWLRVLYKELRVALAVGGILGTTSLAKTYFINGKPLALCGSVGITLMITVVAAKLTGGLLPILAKKLCLDPAIMAGPLITTIVDTTSLFVFFNVARVVLRWPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83889</accession>
    <name>THIO_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Thioredoxin</fullName>
            <shortName>Trx</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trxA</name>
        <name type="ordered locus">TP_0919</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71265">
        <property type="entry name" value="D71265"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882362.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83889"/>
    <dbReference type="SMR" id="O83889"/>
    <dbReference type="STRING" id="243276.TPANIC_0919"/>
    <dbReference type="EnsemblBacteria" id="AAC65875">
        <property type="protein sequence ID" value="AAC65875"/>
        <property type="gene ID" value="TP_0919"/>
    </dbReference>
    <dbReference type="GeneID" id="57879429"/>
    <dbReference type="KEGG" id="tpa:TP_0919"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_3_12"/>
    <dbReference type="OMA" id="KIKICKF"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000120144" description="Thioredoxin">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="105" mass="11391" checksum="637ABB85D9AFE867" modified="1998-11-01" version="1">MALLDISSGNVRKTIETNPLVIVDFWAPWCGSCKMLGPVLEEVESEVGSGVVIGKLNVDDDQDLAVEFNVASIPTLIVFKDGKEVDRSIGFVDKSKILTLIQKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83891</accession>
    <name>O83891_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71265">
        <property type="entry name" value="F71265"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882364.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83891">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0921"/>
    <dbReference type="EnsemblBacteria" id="AAC65876">
        <property type="protein sequence ID" value="AAC65876"/>
        <property type="gene ID" value="TP_0921"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76088">
        <property type="protein sequence ID" value="AGN76088"/>
        <property type="gene ID" value="TPANIC_0921"/>
    </dbReference>
    <dbReference type="GeneID" id="57879431"/>
    <dbReference type="KEGG" id="tpa:TP_0921"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.905"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_12"/>
    <dbReference type="OMA" id="ACGIPYW"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="333"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="445" mass="48644" checksum="04C1A4EF442DA7AB" modified="1998-11-01" version="1">MKIVIIGANHAGTACVNCLTDLTTTNEVVVFDRNNNISFLGCGMALWIGGQIRGSEGLFYANKEQLEKKGARVSMESDITRIDFASKKVYGTARDGSAIAESYDKLIIATGSLPIIPKIDGMDLENVQRIKLFQDAEAVIKKLEQPSIKNIAVIGAGYIGVELAEAFERHQKKVTLIDAMDSSLSNYYDASFRALMDENLRSHHITLAFGQKVQKLRGSNGKVVAVVTDKGEYPADMVMVCIGFSPNTALGKNEVRTFANGAYAVDLKQETSVKDVYAIGDCATVFDNSLGQTSYIALATNAMRSGIVAAHNAAGFPLEGIGVQGSNGINIYDLKMVSTGVTQERAARMGLEVEVTDFEDSQLPAFMEVDNHPVKIRIVFDKKTRVIVGAQMASRHDMSMGIHLFSLAIQERVTIDKLKLLDMFFLPHFNKPYNYVTMAALRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83927</accession>
    <name>O83927_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar basal-body rod protein (FlgG-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71259">
        <property type="entry name" value="D71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882405.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83927">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0961"/>
    <dbReference type="EnsemblBacteria" id="AAC65916">
        <property type="protein sequence ID" value="AAC65916"/>
        <property type="gene ID" value="TP_0961"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76126">
        <property type="protein sequence ID" value="AGN76126"/>
        <property type="gene ID" value="TPANIC_0961"/>
    </dbReference>
    <dbReference type="GeneID" id="57879471"/>
    <dbReference type="KEGG" id="tpa:TP_0961"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.945"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_0_12"/>
    <dbReference type="OMA" id="NLYFAIQ"/>
    <dbReference type="OrthoDB" id="947161at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012836">
        <property type="entry name" value="FlgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02490">
        <property type="entry name" value="flgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="271" mass="30228" checksum="FF611FD60ED314F5" modified="1998-11-01" version="1">MIRGWYTAASGMSAQQRRLDAIAQNLANVDTTSYKRDVAVHKSFPELLLRRVNDDGVVKNPFGSSDVSPIVGKLGLGVEVNELFTEFEQGSLKQTQSPSDIALEGMGFFVIRTPQGEEYTRNGNFLVGVEGYLMTKNGYPVLGENGPLFLQERYYTINQNGEIYVRPIDRPDVDGFFLDRLKIVTFENVRYLQKKGADTYMQTPVSGAPIAAEGPERPAAVQGFVEASNVNVVNEMVRMIEVNRAYEANQKTIQAEDGMMGRLWNEVVRAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>O83936</accession>
    <name>Y970_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0970</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0970</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71260">
        <property type="entry name" value="E71260"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83936"/>
    <dbReference type="EnsemblBacteria" id="AAC65928">
        <property type="protein sequence ID" value="AAC65928"/>
        <property type="gene ID" value="TP_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0970"/>
    <dbReference type="HOGENOM" id="CLU_3334254_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202366" description="Uncharacterized protein TP_0970">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <sequence length="38" mass="4182" checksum="D11D5331CC662A9D" modified="1998-11-01" version="1">MRAHKGVLCSVRQAGSAVRGAARRVRFEGVGFDTQLFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83941</accession>
    <name>Y976_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0976</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0976</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71257">
        <property type="entry name" value="F71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882420.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83941"/>
    <dbReference type="IntAct" id="O83941">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0976"/>
    <dbReference type="EnsemblBacteria" id="AAC65940">
        <property type="protein sequence ID" value="AAC65940"/>
        <property type="gene ID" value="TP_0976"/>
    </dbReference>
    <dbReference type="GeneID" id="57879485"/>
    <dbReference type="KEGG" id="tpa:TP_0976"/>
    <dbReference type="eggNOG" id="ENOG5030273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555407_0_0_12"/>
    <dbReference type="OMA" id="SAHEMML"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202368" description="Uncharacterized protein TP_0976">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="459" mass="49188" checksum="AB54E7F5BCB4D3BF" modified="1998-11-01" version="1">MVLTQKNLVKRTTESTETEAVSDLLVSELLILGLSLPALLRPFSRQSRKISAIPLLPVLALSVGALTVLGQGLTLDLTLSLVSSSVVCLTELPRLVAFSQGIPNDLYSAGARIARVLLLVAGVFTLVIVCLCAPEPGYRPSRSVVRSSFSLRLGNTKVNAGLLLSLANPYETSHLDNPSAPHPSENPQSRAHPKQNPVGVNVVVLKNTPQSAHRAHPETLELMLAERGYTVFVPYQDAYSPSYSAASLAAPMRTSPGVVLLSSALRGVPFDVPTPYVSRRANTIDAATFEDAHVPALFPALFALCRHAPTFVYAESAHEVMLSRFLQQQPHACAGVFFVLPDSAARGPHHAPAVQGAPPPVDTAGVASAVRGASRTLPAVYRQYVHAAEAAWAELASTDILAAYLAGLPRDRHRTRLQARATQVDQWIRAQLHLSEPVLPHAQALSHHTVHAGGTYDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83947</accession>
    <name>O83947_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GlpG protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71258">
        <property type="entry name" value="D71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882426.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83947">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0982"/>
    <dbReference type="MEROPS" id="S54.025"/>
    <dbReference type="EnsemblBacteria" id="AAC65937">
        <property type="protein sequence ID" value="AAC65937"/>
        <property type="gene ID" value="TP_0982"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76146">
        <property type="protein sequence ID" value="AGN76146"/>
        <property type="gene ID" value="TPANIC_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0982"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.967"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_4_1_12"/>
    <dbReference type="OMA" id="FILLAPW"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="208" mass="23418" checksum="086B57888391798E" modified="1998-11-01" version="1">MSVIRKPFRYSYTNVTLSLVLANGAVFVITSLVESLGIYLALVPGLVRYHRMYWQIFTYQFVHSGVWHLLFNMLGLVFFGQTIEKKMGSSEMLLFYLLVGTLCGAGACAAYLCVGRLNVLLLGASGSIFAILFLFSVMFPTALIYLWGVIPIPAPLLIVGYILFEIFDLFFSRDNVSHLTHLLGVLFAWGYIRIRFGIKPLKVWSIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83959</accession>
    <name>O83959_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71255">
        <property type="entry name" value="C71255"/>
    </dbReference>
    <dbReference type="IntAct" id="O83959">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0994"/>
    <dbReference type="EnsemblBacteria" id="AAC26582">
        <property type="protein sequence ID" value="AAC26582"/>
        <property type="gene ID" value="TP_0994"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76158">
        <property type="protein sequence ID" value="AGN76158"/>
        <property type="gene ID" value="TPANIC_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0994"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.979"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_3_12"/>
    <dbReference type="OMA" id="HIYASEF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC26582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="269" mass="29534" checksum="0ECB21D720F6D319" modified="1998-11-01" version="1">MEVGTRAGDYQERKALLLQACAGRSLPSCLHFSVGVRPAPEPIAHPETALSLLRSDVRALCAEQAPYRALGECGLDRHWNGPQVACKARKGSGVRGTPDLDAEEYLFKAQLSIAKAQNLPLIIHSRDAFEPTLRCLDSVGWRKGVMHCFSYGVVEAHAFLERGLYISCAGTLTYAKTTSELLARDALIRSIPLDRLLLETDTPYLAPVPHRGTHNRPEYVRHTYALVANILGISEKALAQHVFANCCALFEAQEPTEACSQAHAPTRYT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83973</accession>
    <name>GPDA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">TP_1009</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71252">
        <property type="entry name" value="E71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882453.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83973"/>
    <dbReference type="SMR" id="O83973"/>
    <dbReference type="IntAct" id="O83973">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1009"/>
    <dbReference type="EnsemblBacteria" id="AAC65960">
        <property type="protein sequence ID" value="AAC65960"/>
        <property type="gene ID" value="TP_1009"/>
    </dbReference>
    <dbReference type="GeneID" id="57879520"/>
    <dbReference type="KEGG" id="tpa:TP_1009"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_0_12"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138051" description="Glycerol-3-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="276"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="356" mass="37879" checksum="03967CE61767D915" modified="1998-11-01" version="1">MASIAILGGGAWGTALAASLTVNGHTVMLWARRRQTCDAINARNENVQYLPGITLPAALCASPDMAYVCAGADLIVLAVPSCYLAEVAALMNTTPRFQRLRTAAVGQEYPLIGILTKGFIPDQEGMPHLITDALGALLPSGAHGQLVYISGPSHAQEVAQGKVTGLIAASQNPMAAIRVRELLRSKRVQVYSSLDVVGVQVCAAVKNVIAIAFGLLDAMAEHSEAFGDNTESMLLAAGLNEIQTIGKQLGSTHPETFTSLAGIGDLDVTCRSAYGRNRRFGRDIVHKGILDSFSGIQDLVSRLPEVGYLAEGVVACMHVQRLAERDRLKVPICAGLYAILNREKGADTFMQEILGW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83974</accession>
    <name>NDK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name type="ordered locus">TP_1010</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71252">
        <property type="entry name" value="F71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882454.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83974"/>
    <dbReference type="SMR" id="O83974"/>
    <dbReference type="IntAct" id="O83974">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1010"/>
    <dbReference type="EnsemblBacteria" id="AAC65961">
        <property type="protein sequence ID" value="AAC65961"/>
        <property type="gene ID" value="TP_1010"/>
    </dbReference>
    <dbReference type="GeneID" id="57879521"/>
    <dbReference type="KEGG" id="tpa:TP_1010"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_12"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000137069" description="Nucleoside diphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="149" mass="16657" checksum="BB329539671E80BE" modified="1998-11-01" version="1">MAFETTFVMLKPGVLQRRLVGEVLSRFERKGLVLTALRLLCVDTATAELHYAEHREKPFYPSLIAYITSAPVVALAFKGENAISLVRTLCGSTRVEHAQPGTIRGDFALRTTTNIVHASDSPESAARELALYFSAQDFVEWRDGNYDFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83982</accession>
    <name>GATC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Glutamyl-tRNA(Gln) amidotransferase subunit C</fullName>
            <shortName>Glu-ADT subunit C</shortName>
            <ecNumber>6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gatC</name>
        <name type="ordered locus">TP_1019</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GatC family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65969" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.3.5.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65969.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71253">
        <property type="entry name" value="G71253"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83982"/>
    <dbReference type="IntAct" id="O83982">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1019"/>
    <dbReference type="EnsemblBacteria" id="AAC65969">
        <property type="protein sequence ID" value="AAC65969"/>
        <property type="gene ID" value="TP_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1019"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_3_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105355" description="Glutamyl-tRNA(Gln) amidotransferase subunit C">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="114" mass="12559" checksum="F25013CFAC01C509" modified="2000-05-30" version="2">MAQQRITSDIFAQLLTLSHLESSECAVGLATQIEDIIQYFSVVEQFDPGPRDDPDTDNAQGRCSQGNKIDVDCCPDWVRKDVALPGLSVHDLKRLSTEFADGYFRAPRALDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83994</accession>
    <name>O83994_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein L (TprL)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_1031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71252">
        <property type="entry name" value="B71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882475.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1031"/>
    <dbReference type="EnsemblBacteria" id="AAC65979">
        <property type="protein sequence ID" value="AAC65979"/>
        <property type="gene ID" value="TP_1031"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76195">
        <property type="protein sequence ID" value="AGN76195"/>
        <property type="gene ID" value="TPANIC_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1031"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.1089"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="KRVFSRQ"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="317"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="514" mass="56509" checksum="94862730F3B72099" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-09-26" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O84003</accession>
    <name>CLPP2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 2</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP2</name>
        <name type="synonym">clpP-2</name>
        <name type="ordered locus">TP_1041</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC26595" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26595.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71250">
        <property type="entry name" value="H71250"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342706.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O84003"/>
    <dbReference type="SMR" id="O84003"/>
    <dbReference type="STRING" id="243276.TPANIC_1041"/>
    <dbReference type="EnsemblBacteria" id="AAC26595">
        <property type="protein sequence ID" value="AAC26595"/>
        <property type="gene ID" value="TP_1041"/>
    </dbReference>
    <dbReference type="GeneID" id="57879552"/>
    <dbReference type="KEGG" id="tpa:TP_1041"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_4_0_12"/>
    <dbReference type="OMA" id="RFIQPHA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="BRENDA" id="3.4.21.92">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179705" description="ATP-dependent Clp protease proteolytic subunit 2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="199" mass="22086" checksum="CC5025ACD9AB63AE" modified="2001-09-26" version="2">MRCDATQEKRAHSESGESVFFQKFLETRQILLSGEISKDLAEGIVRQLFVLESLSVSKPIYMYVDSPGGDVDAGYAIFDVIRFVKTPVYTIGMGLVASAGVLVLLAAKKDCRFGLRNSRYLIHQPLSGMRGVATDIEIHARELEKTRSKLNALIASETGVSLDKVAQDTNRDYWLDASQALEYGLISNLIEKRADLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O88138</accession>
    <name>O88138_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tpr protein C (TprC)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Tpr protein D (TprD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0117</name>
        <name evidence="5" type="ordered locus">TP_0131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71365">
        <property type="entry name" value="D71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881566.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O88138">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0117"/>
    <dbReference type="TCDB" id="1.B.38.1.5">
        <property type="family name" value="the treponema porin major surface protein (tp-msp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65107">
        <property type="protein sequence ID" value="AAC65107"/>
        <property type="gene ID" value="TP_0117"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65117">
        <property type="protein sequence ID" value="AAC65117"/>
        <property type="gene ID" value="TP_0131"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75336">
        <property type="protein sequence ID" value="AGN75336"/>
        <property type="gene ID" value="TPANIC_0117"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75353">
        <property type="protein sequence ID" value="AGN75353"/>
        <property type="gene ID" value="TPANIC_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0117"/>
    <dbReference type="KEGG" id="tpa:TP_0131"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.119"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="PNIMMPL"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503445" evidence="1">
        <location>
            <begin position="23"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_N" evidence="2">
        <location>
            <begin position="84"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="3">
        <location>
            <begin position="400"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="598" mass="64736" checksum="63B0920477B4FCD4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-04-01" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>P16055</accession>
    <accession>O83201</accession>
    <name>TA15_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>15 kDa lipoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Major membrane immunogen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tpp15</name>
        <name type="ordered locus">TP_0171</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Mol. Microbiol." volume="4" first="1371" last="1379">
            <title>Lipid modification of the 15 kilodalton major membrane immunogen of Treponema pallidum.</title>
            <authorList>
                <person name="Purcell B.K."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="2280688"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.1990.tb00716.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P16055"/>
    <dbReference type="SMR" id="P16055"/>
    <dbReference type="IntAct" id="P16055">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0171"/>
    <dbReference type="EnsemblBacteria" id="AAC65160">
        <property type="protein sequence ID" value="AAC65160"/>
        <property type="gene ID" value="TP_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0171"/>
    <dbReference type="eggNOG" id="COG4939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119924_1_0_12"/>
    <dbReference type="OMA" id="HGYKGQI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017058">
        <property type="entry name" value="Major_M_immunogen_Tpp15_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036531">
        <property type="entry name" value="Tpp15_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018199" description="15 kDa lipoprotein">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3." evidence="1" ref="3">
        <original>R</original>
        <variation>GA</variation>
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; AAC65160." evidence="1" ref="3">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="141" mass="15783" checksum="BC00878646EADCF5" modified="1990-04-01" version="1" precursor="true">MVKRGRFALCLAVLLGACSFSSIPNGTYRATYQDFDENGWKDFLEVTFDGGKMVQVVYDYQHKEGRFKSQDADYHRVMYASSGIGPEKAFRELADALLEKGNPEMVDVVTGATVSSQSFRRLGRALLQSARRGEKEAIISR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-02-01" modified="2022-05-25" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>P19478</accession>
    <name>TA34_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>34 kDa membrane antigen</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Pathogen-specific membrane antigen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tpd</name>
        <name type="ordered locus">TP_0971</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="3314" last="3323">
            <title>Molecular characterization of the pathogen-specific, 34-kilodalton membrane immunogen of Treponema pallidum.</title>
            <authorList>
                <person name="Swancutt M.A."/>
                <person name="Riley B.S."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="2680970"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PARTIAL PROTEIN SEQUENCE</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1991" name="Infect. Immun." volume="59" first="3536" last="3546">
            <title>Characterization of the 35-kilodalton Treponema pallidum subsp. pallidum recombinant lipoprotein TmpC and antibody response to lipidated and nonlipidated T. pallidum antigens.</title>
            <authorList>
                <person name="Schouls L.M."/>
                <person name="van der Heide H.G.J."/>
                <person name="van Embden J.D.A."/>
            </authorList>
            <dbReference type="PubMed" id="1894360"/>
        </citation>
        <scope>MUTAGENESIS OF CYS-20</scope>
        <scope>DIACYLGLYCEROL AT CYS-20</scope>
        <scope>PALMITOYLATION AT CYS-20</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>This antigen is a pathogen-specific membrane immunogen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0423 family.</text>
    </comment>
    <dbReference type="EMBL" id="J04241">
        <property type="protein sequence ID" value="AAA27474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A40182">
        <property type="entry name" value="A40182"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882415.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="2O6C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=18-204"/>
    </dbReference>
    <dbReference type="PDB" id="2O6D">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.86 A"/>
        <property type="chains" value="A/B=18-204"/>
    </dbReference>
    <dbReference type="PDB" id="2O6E">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=18-204"/>
    </dbReference>
    <dbReference type="PDB" id="2O6F">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.63 A"/>
        <property type="chains" value="A/B=18-204"/>
    </dbReference>
    <dbReference type="PDB" id="3PJL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=21-204"/>
    </dbReference>
    <dbReference type="PDB" id="3PJN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=21-204"/>
    </dbReference>
    <dbReference type="PDBsum" id="2O6C"/>
    <dbReference type="PDBsum" id="2O6D"/>
    <dbReference type="PDBsum" id="2O6E"/>
    <dbReference type="PDBsum" id="2O6F"/>
    <dbReference type="PDBsum" id="3PJL"/>
    <dbReference type="PDBsum" id="3PJN"/>
    <dbReference type="AlphaFoldDB" id="P19478"/>
    <dbReference type="SMR" id="P19478"/>
    <dbReference type="IntAct" id="P19478">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0971"/>
    <dbReference type="EnsemblBacteria" id="AAC65921">
        <property type="protein sequence ID" value="AAC65921"/>
        <property type="gene ID" value="TP_0971"/>
    </dbReference>
    <dbReference type="GeneID" id="57879480"/>
    <dbReference type="KEGG" id="tpa:TP_0971"/>
    <dbReference type="eggNOG" id="COG3470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100963_0_0_12"/>
    <dbReference type="OMA" id="GRFWTEP"/>
    <dbReference type="OrthoDB" id="1456006at2"/>
    <dbReference type="EvolutionaryTrace" id="P19478"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018470">
        <property type="entry name" value="Metal-bd_Tp34-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10634">
        <property type="entry name" value="Iron_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017018">
        <property type="entry name" value="Tp34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018201" description="34 kDa membrane antigen">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1 2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="4">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of lipid incorporation." evidence="2">
        <original>C</original>
        <variation>S</variation>
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="61"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="helix" evidence="5">
        <location>
            <begin position="98"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="141"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="turn" evidence="5">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="strand" evidence="5">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1894360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="1894360"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2O6F"/>
        </source>
    </evidence>
    <sequence length="204" mass="22085" checksum="2ABD8A42965034D0" modified="1991-02-01" version="1" precursor="true">MKRVSLLGSAAIFALVFSACGGGGEHQHGEEMMAAVPAPDAEGAAGFDEFPIGEDRDVGPLHVGGVYFQPVEMHPAPGAQPSKEEADCHIEADIHANEAGKDLGYGVGDFVPYLRVVAFLQKHGSEKVQKVMFAPMNAGDGPHYGANVKFEEGLGTYKVRFEIAAPSHDEYSLHIDEQTGVSGRFWSEPLVAEWDDFEWKGPQW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>P29723</accession>
    <accession>O83584</accession>
    <name>TA47_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Putative DD-carboxypeptidase TP_0574</fullName>
            <ecNumber evidence="8">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">47 kDa lipoprotein</fullName>
            <shortName evidence="9">Tp47</shortName>
            <shortName evidence="11">Tpp47</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">47 kDa membrane antigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">47-kilodalton major integral membrane immunogen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0574</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Infect. Immun." volume="60" first="1568" last="1576">
            <title>Analysis of the N-terminal region of the 47-kilodalton integral membrane lipoprotein of Treponema pallidum.</title>
            <authorList>
                <person name="Weigel L.M."/>
                <person name="Brandt M.E."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="1372297"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 84-96; 126-143; 207-221; 266-298; 340-350; 366-390 AND 392-414</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="196" last="203">
            <title>Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum.</title>
            <authorList>
                <person name="Hsu P.L."/>
                <person name="Chamberlain N.R."/>
                <person name="Orth K."/>
                <person name="Moomaw C.R."/>
                <person name="Zhang L.Q."/>
                <person name="Slaughter C.A."/>
                <person name="Radolf J.D."/>
                <person name="Sell S."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="2642466"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-434</scope>
        <scope>PROTEIN SEQUENCE OF 84-96; 126-143; 207-221; 266-298; 340-350 AND 392-414</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="1248" last="1254">
            <title>Penicillin-binding proteins and peptidoglycan of Treponema pallidum subsp. pallidum.</title>
            <authorList>
                <person name="Radolf J.D."/>
                <person name="Moomaw C."/>
                <person name="Slaughter C.A."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="2647634"/>
        </citation>
        <scope>PENICILLIN-BINDING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="2878" last="2885">
            <title>Acylation of the 47-kilodalton major membrane immunogen of Treponema pallidum determines its hydrophobicity.</title>
            <authorList>
                <person name="Chamberlain N.R."/>
                <person name="DeOgny L."/>
                <person name="Slaughter C."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="2668192"/>
        </citation>
        <scope>PALMITOYLATION AT CYS-20</scope>
        <scope>PROBABLE READTHROUGH</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="1994" name="Proc. Natl. Acad. Sci. U.S.A." volume="91" first="11611" last="11615">
            <title>The 47-kDa major lipoprotein immunogen of Treponema pallidum is a penicillin-binding protein with carboxypeptidase activity.</title>
            <authorList>
                <person name="Weigel L.M."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="7972112"/>
            <dbReference type="DOI" id="10.1073/pnas.91.24.11611"/>
        </citation>
        <scope>POSSIBLE FUNCTION AS A ZINC-DEPENDENT CARBOXYPEPTIDASE</scope>
        <scope>PENICILLIN-BINDING</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="7">
        <citation type="journal article" date="1999" name="Science" volume="285" first="732" last="736">
            <title>Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors.</title>
            <authorList>
                <person name="Brightbill H.D."/>
                <person name="Libraty D.H."/>
                <person name="Krutzik S.R."/>
                <person name="Yang R.B."/>
                <person name="Belisle J.T."/>
                <person name="Bleharski J.R."/>
                <person name="Maitland M."/>
                <person name="Norgard M.V."/>
                <person name="Plevy S.E."/>
                <person name="Smale S.T."/>
                <person name="Brennan P.J."/>
                <person name="Bloom B.R."/>
                <person name="Godowski P.J."/>
                <person name="Modlin R.L."/>
            </authorList>
            <dbReference type="PubMed" id="10426995"/>
            <dbReference type="DOI" id="10.1126/science.285.5428.732"/>
        </citation>
        <scope>FUNCTION IN INFECTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DIACYLGLYCEROL AT CYS-20</scope>
        <scope>PALMITOYLATION AT CYS-20</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2001" name="J. Immunol." volume="166" first="2444" last="2450">
            <title>Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.</title>
            <authorList>
                <person name="Hertz C.J."/>
                <person name="Kiertscher S.M."/>
                <person name="Godowski P.J."/>
                <person name="Bouis D.A."/>
                <person name="Norgard M.V."/>
                <person name="Roth M.D."/>
                <person name="Modlin R.L."/>
            </authorList>
            <dbReference type="PubMed" id="11160304"/>
            <dbReference type="DOI" id="10.4049/jimmunol.166.4.2444"/>
        </citation>
        <scope>FUNCTION IN HOST DENDRITIC CELL MATURATION</scope>
    </reference>
    <reference evidence="17" key="9">
        <citation type="journal article" date="2002" name="J. Biol. Chem." volume="277" first="41857" last="41864">
            <title>Crystal structure of the 47-kDa lipoprotein of Treponema pallidum reveals a novel penicillin-binding protein.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Machius M."/>
                <person name="Norgard M.V."/>
                <person name="Tomchick D.R."/>
            </authorList>
            <dbReference type="PubMed" id="12196546"/>
            <dbReference type="DOI" id="10.1074/jbc.M207402200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 26-434</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>MUTAGENESIS OF 24-HIS--HIS-28; SER-119; LYS-306 AND CYS-315</scope>
        <scope>PENICILLIN-BINDING</scope>
    </reference>
    <comment type="function">
        <text evidence="3 6 8 16">A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus (PubMed:7972112, PubMed:12196546). Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates (PubMed:7972112). May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, not the lipoprotein moiety, is toxic (PubMed:7972112). Binds penicillin (PubMed:2647634, PubMed:7972112). Penicillin binding is covalent, does not require lipidation, and is zinc-dependent (PubMed:7972112, PubMed:12196546). While this protein has beta-lactamase activity in vitro, that is probably not its role in vivo, as T.pallidum is very sensitive to penicillin antibiotics (PubMed:12196546).</text>
    </comment>
    <comment type="function">
        <text evidence="1 2 4 5">A pathogen-specific membrane antigen (PubMed:2642466, PubMed:1372297). Most abundant of the membrane lipoproteins, only found in pathogenic treponemes, suggesting that it is an important structural moiety in the cell envelope of virulent treponemal subspecies. A lipopeptide corresponding to the first 6 mature residues induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells (PubMed:10426995). Stimulates host (human) dendritic cell maturation to become MHC class II-positive antigen presenting cells via TLR2, which depends on lipidation; nonlipidated protein does not stimulate maturation (PubMed:11160304).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3 8">Carboxypeptidase activity is stimulated by zinc (PubMed:7972112). Penicillin-binding is stimulated by zinc (PubMed:12196546).</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Probably a monomer; a non-lipidated construct (residues 22-434) is monomeric in solution but crystallizes as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell inner membrane</location>
            <topology evidence="14">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4 5 6 7">The N-terminus is blocked (PubMed:2642466). Present as a doublet of low abundance 48 kDa and high abundance 47 kDa proteins (PubMed:2647634, PubMed:2668192, PubMed:1372297). The longer form is probably due to readthrough of the stop codon; the extra amino acids at the C-terminus would be X-Lys-Arg-Gly-Val-Leu-Ser-Arg-Val-Ser, a peptide antibody against this sequence detects only the 48 kDa form (PubMed:2668192).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1 4 8">A recombinant non-lipidated form (residues 20-434) is recognized by human antisera, indicating the lipidation site is not essential for antigenicity, although the acylated lipopeptide clearly is antigenic (PubMed:1372297, PubMed:10426995). The non-lipidated form binds also penicillin (PubMed:7972112).</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="8"/>
    <dbReference type="EMBL" id="M88769">
        <property type="protein sequence ID" value="AAA75016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="M88769">
        <property type="protein sequence ID" value="AAA75017.1"/>
        <property type="status" value="ALT_TERM"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71309">
        <property type="entry name" value="D71309"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882021.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="1O75">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=20-434"/>
    </dbReference>
    <dbReference type="PDBsum" id="1O75"/>
    <dbReference type="AlphaFoldDB" id="P29723"/>
    <dbReference type="SMR" id="P29723"/>
    <dbReference type="STRING" id="243276.TPANIC_0574"/>
    <dbReference type="DrugBank" id="DB02879">
        <property type="generic name" value="2,3-Di-O-Sulfo-Alpha-D-Glucopyranose"/>
    </dbReference>
    <dbReference type="PRIDE" id="P29723"/>
    <dbReference type="EnsemblBacteria" id="AAC65545">
        <property type="protein sequence ID" value="AAC65545"/>
        <property type="gene ID" value="TP_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0574"/>
    <dbReference type="HOGENOM" id="CLU_562301_0_0_12"/>
    <dbReference type="OMA" id="TRATTNH"/>
    <dbReference type="OrthoDB" id="751593at2"/>
    <dbReference type="SABIO-RK" id="P29723"/>
    <dbReference type="EvolutionaryTrace" id="P29723"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029220">
        <property type="entry name" value="BP-Tp47_dom_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029221">
        <property type="entry name" value="PBP-Tp47_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029218">
        <property type="entry name" value="PBP-Tp47_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038698">
        <property type="entry name" value="PBP_Tp47_domC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038031">
        <property type="entry name" value="Tp47_mid_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036154">
        <property type="entry name" value="Tp47_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14889">
        <property type="entry name" value="PBP-Tp47_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14888">
        <property type="entry name" value="PBP-Tp47_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81986">
        <property type="entry name" value="SSF81986"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82220">
        <property type="entry name" value="SSF82220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018202" description="Putative DD-carboxypeptidase TP_0574">
        <location>
            <begin position="20"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="14 15">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="14">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Protein still binds ampicillin, in nonlipidated fragment (residues 21-43), crystallized." evidence="9">
        <original>HHETH</original>
        <variation>SHETS</variation>
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Protein still binds ampicillin and penicillin, in nonlipidated fragment (residues 21-43)." evidence="9">
        <original>S</original>
        <variation>C</variation>
        <variation>G</variation>
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Protein still binds ampicillin, in nonlipidated fragment (residues 21-43)." evidence="9">
        <original>K</original>
        <variation>Q</variation>
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Protein still binds ampicillin, in nonlipidated fragment (residues 21-43)." evidence="9">
        <original>C</original>
        <variation>A</variation>
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA75016/AAA75017." evidence="13" ref="1">
        <original>G</original>
        <variation>V</variation>
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="27"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="36"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="79"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="208"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="231"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="264"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="274"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="307"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="312"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="helix" evidence="18">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="344"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="turn" evidence="18">
        <location>
            <begin position="374"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="380"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="392"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="414"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="422"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="strand" evidence="18">
        <location>
            <begin position="427"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="10426995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="11160304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12196546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="1372297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="2642466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="2647634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="2668192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="7972112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="12196546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="1372297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="11">
        <source>
            <dbReference type="PubMed" id="7972112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="12">
        <source>
            <dbReference type="PubMed" id="9665876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13"/>
    <evidence type="ECO:0000305" key="14">
        <source>
            <dbReference type="PubMed" id="10426995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="15">
        <source>
            <dbReference type="PubMed" id="2668192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="16">
        <source>
            <dbReference type="PubMed" id="7972112"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="17">
        <source>
            <dbReference type="PDB" id="1O75"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="1O75"/>
        </source>
    </evidence>
    <sequence length="434" mass="47665" checksum="B5C2A75D4A8849E0" modified="1998-12-15" version="2" precursor="true">MKVKYALLSAGALQLLVVGCGSSHHETHYGYATLSYADYWAGELGQSRDVLLAGNAEADRAGDLDAGMFDAVSRATHGHGAFRQQFQYAVEVLGEKVLSKQETEDSRGRKKWEYETDPSVTKMVRASASFQDLGEDGEIKFEAVEGAVALADRASSFMVDSEEYKITNVKVHGMKFVPVAVPHELKGIAKEKFHFVEDSRVTENTNGLKTMLTEDSFSARKVSSMESPHDLVVDTVGTGYHSRFGSDAEASVMLKRADGSELSHREFIDYVMNFNTVRYDYYGDDASYTNLMASYGTKHSADSWWKTGRVPRISCGINYGFDRFKGSGPGYYRLTLIANGYRDVVADVRFLPKYEGNIDIGLKGKVLTIGGADAETLMDAAVDVFADGQPKLVSDQAVSLGQNVLSADFTPGTEYTVEVRFKEFGSVRAKVVAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>P56822</accession>
    <name>Y315_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0315</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0315</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To T.pallidum TP_0127, TP_0618 and TP_0619.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P56822"/>
    <dbReference type="STRING" id="243276.TPANIC_0315"/>
    <dbReference type="EnsemblBacteria" id="AAC65306">
        <property type="protein sequence ID" value="AAC65306"/>
        <property type="gene ID" value="TP_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0315"/>
    <dbReference type="HOGENOM" id="CLU_091716_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202233" description="Uncharacterized protein TP_0315">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="215" mass="22796" checksum="05CDFEC99530B68D" modified="2000-05-30" version="1">MVRGCRVGQRTGTVGVRVFPVGLCALSLQARDCRGMCGKRLGKVMVLGCMLPGVAARVSLSPKLGVYGDARGGSDLWGICIQAPTMPDTENQAPPRYAPETPLVGLDVAFRAENGFLLQLTVDAALTRLMFCGRCLAGYSFRPGEGSTHLSVAAGFECTALIYDSQHFLSVLGQGLLQPSSSSYSAGNWHRPRSLLGVLTCTAKEVGAIHEESAY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>P96131</accession>
    <name>RL28_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmB</name>
        <name type="synonym">rpl28</name>
        <name type="ordered locus">TP_0362</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1996-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Greene S.R."/>
                <person name="Stamm L.V."/>
                <person name="Hardham J.M."/>
                <person name="Barnes N.Y."/>
                <person name="Fyre J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="U70868">
        <property type="protein sequence ID" value="AAB39650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71334">
        <property type="entry name" value="H71334"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881810.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96131"/>
    <dbReference type="SMR" id="P96131"/>
    <dbReference type="IntAct" id="P96131">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0362"/>
    <dbReference type="EnsemblBacteria" id="AAC65347">
        <property type="protein sequence ID" value="AAC65347"/>
        <property type="gene ID" value="TP_0362"/>
    </dbReference>
    <dbReference type="GeneID" id="57879572"/>
    <dbReference type="KEGG" id="tpa:TP_0362"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_12"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178580" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="78" mass="8440" checksum="B853CC5EC51057B0" modified="1997-05-01" version="1">MARRCGLCGKGTISGCAVSKSMHHCKRVWKPNLLAVRVVVDGSALNMRICARCLRSNPLMKKAQPRANAPLRAAAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUH9</accession>
    <name>F7IUH9_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein (FlbD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71292">
        <property type="entry name" value="B71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882171.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0726"/>
    <dbReference type="EnsemblBacteria" id="AAC65691">
        <property type="protein sequence ID" value="AAC65691"/>
        <property type="gene ID" value="TP_0726"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75900">
        <property type="protein sequence ID" value="AGN75900"/>
        <property type="gene ID" value="TPANIC_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0726"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.715"/>
    <dbReference type="eggNOG" id="COG1582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173020_2_0_12"/>
    <dbReference type="OMA" id="HQIESIE"/>
    <dbReference type="OrthoDB" id="2007051at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071978">
        <property type="term" value="P:bacterial-type flagellum-dependent swarming motility"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="65" mass="7522" checksum="FD2E0F54779523BD" modified="2011-07-27" version="1">MIKVTRLNGNENWVNPHHIETMRCTPDVTLQMLSGKCYVVRESVQEVIDKIVSYRRSIGCLNDET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O66106</accession>
    <name>RSMG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glucose-inhibited division protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="synonym">gidB</name>
        <name type="ordered locus">TP_0946</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Radolf J.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="U97573">
        <property type="protein sequence ID" value="AAC08056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71260">
        <property type="entry name" value="H71260"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882389.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O66106"/>
    <dbReference type="SMR" id="O66106"/>
    <dbReference type="IntAct" id="O66106">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0946"/>
    <dbReference type="EnsemblBacteria" id="AAC65903">
        <property type="protein sequence ID" value="AAC65903"/>
        <property type="gene ID" value="TP_0946"/>
    </dbReference>
    <dbReference type="GeneID" id="57879456"/>
    <dbReference type="KEGG" id="tpa:TP_0946"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_0_12"/>
    <dbReference type="OMA" id="IECELSN"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184360" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <sequence length="222" mass="24587" checksum="F1E1F3AFF903BE59" modified="1998-08-01" version="1">MVTPSQHALLAEGVAHLTDARTAPALCALLKQYLEELILFNTRAHLVHVTHTEELITHHLLDSLSAWPHFTNARAIADIGSGAGLPGIPLACALALYAPETELTLIERREKRIAFLENACARLALPHLRIVHADAHDLTPYTYDAITFRALCPLNHPTVYMLLNKLRPGGVILAYKGKRKLIEQETRDFLPQSCSVFPLHVPFLHEARHLVAIHTPCAAPPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83062</accession>
    <name>GRAD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative GreA-associated domains protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0018</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71377">
        <property type="entry name" value="G71377"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83062"/>
    <dbReference type="IntAct" id="O83062">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0018"/>
    <dbReference type="EnsemblBacteria" id="AAC65010">
        <property type="protein sequence ID" value="AAC65010"/>
        <property type="gene ID" value="TP_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0018"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.19"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417341_0_0_12"/>
    <dbReference type="OMA" id="KKALHRY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177010" description="Putative GreA-associated domains protein">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="GRAD2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GRAD1">
        <location>
            <begin position="153"/>
            <end position="657"/>
        </location>
    </feature>
    <sequence length="657" mass="75688" checksum="AF0DCFB7BAF93A4A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83068</accession>
    <name>O83068_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71376">
        <property type="entry name" value="D71376"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881473.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83068">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0024"/>
    <dbReference type="EnsemblBacteria" id="AAC65018">
        <property type="protein sequence ID" value="AAC65018"/>
        <property type="gene ID" value="TP_0024"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75245">
        <property type="protein sequence ID" value="AGN75245"/>
        <property type="gene ID" value="TPANIC_0024"/>
    </dbReference>
    <dbReference type="GeneID" id="57878566"/>
    <dbReference type="KEGG" id="tpa:TP_0024"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.20"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_3_12"/>
    <dbReference type="OMA" id="AIGANIQ"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="236" mass="26746" checksum="EA32B1C3C24833C7" modified="1998-11-01" version="1">MKRFALIGLGDFGLSMLKELLKLTNNIVLLDRDRTLVETYRSRVRIVRAIDVLDEFTLCKMIPQDINAAVIDLGVKIESSIMITTFLKKLEIADIVVKAYSAEQGHILSSVGATHVVLPDREAAKKVTPMIAFDLLFNFMPLSAQLAIAEMAVHEDYVGRTLREVDVRKNFSLNIIAIRKRDAEDFCFINDPEYCFEANDVLLVAGSHKDIYAQSQDKLAHTHSFSDFFKQWFLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83070</accession>
    <name>O83070_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TP_0026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71376">
        <property type="entry name" value="F71376"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881475.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83070">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0026"/>
    <dbReference type="EnsemblBacteria" id="AAC65020">
        <property type="protein sequence ID" value="AAC65020"/>
        <property type="gene ID" value="TP_0026"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75247">
        <property type="protein sequence ID" value="AGN75247"/>
        <property type="gene ID" value="TPANIC_0026"/>
    </dbReference>
    <dbReference type="GeneID" id="57878568"/>
    <dbReference type="KEGG" id="tpa:TP_0026"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.22"/>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047835_1_0_12"/>
    <dbReference type="OMA" id="YRKNEEF"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="234"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAC65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="340" mass="37533" checksum="B8D92ECCF94BE2A5" modified="1998-11-01" version="1">MNRTESPRGLIKATVREQDRGRTVYKKIAQFLSLIGEEQAALVLKQLEPAQIEAVVAELLTLKPLSPEEAREILREFSALCARVSPVTGGLRAAQSMLSKAFGEEKADLILKRAVPAAQPKPFEFLAALEASQLLPLLEGELPATKTLILSQLPPESAAHYLSNISTEEKKDLIVRLAKLKHVNPQVLQVMSDSLHKKFAALHLSQRRDLDGHAVLAAILKKMERATEHSILHALAEKNPTLAARVRTHLFTLDDIPALPDTFLQKHLASCSEKTLAALINTNHPAFVQKILSNLSKNRAQLVRDEYDTFPPSAHDTRTITEHFLATLRSAGAQQHIASK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83071</accession>
    <name>O83071_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hemolysin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="E71374"/>
    </dbReference>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0027"/>
    <dbReference type="EnsemblBacteria" id="AAC65023">
        <property type="protein sequence ID" value="AAC65023"/>
        <property type="gene ID" value="TP_0027"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75248">
        <property type="protein sequence ID" value="AGN75248"/>
        <property type="gene ID" value="TPANIC_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0027"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.23"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_12"/>
    <dbReference type="OMA" id="EHTMVRN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="407" mass="45023" checksum="B00FD712159D0B69" modified="1998-11-01" version="1">MLSMLFSAAETAFCALNTLRLRYLYEKRHARARVAMRILRRKNFYLAAVVIGNTLASSALSAVIALFARALFGIHAVGWSIGAGTVLTLLFGEIIPKSLALCRPNAVALHTARFLQWSALMLTPFVQVFCMARSALLRLARVACHTPSLRVTDDDLHTVLYAGEADGTVTSRERALYQRILHSASLTARDIMTCRAQLIAVPRASSLAEAIACAQKMRVSRVPVYERSVDWIIGIFDVKKFLCSEEVDGRDLEECGTLMQHVSAPVFVFECTRLAYVQHKLRAHSRAVAIVLDEYGGTAGLVTKHNIYQAFFKSSAHEFPVNSTGPQVTRAGVRAYIFPGSLRLDEINDLLGTDFSSCTSETLAGLIMEYTGCIPDPGTTVVFGSWRCVVLQLHVRRIVRVRFEFQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83078</accession>
    <name>Y035_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable metal transport system ATP-binding protein TP_0035</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0035</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal. Probably responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71375">
        <property type="entry name" value="E71375"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881484.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83078"/>
    <dbReference type="SMR" id="O83078"/>
    <dbReference type="IntAct" id="O83078">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0035"/>
    <dbReference type="EnsemblBacteria" id="AAC65030">
        <property type="protein sequence ID" value="AAC65030"/>
        <property type="gene ID" value="TP_0035"/>
    </dbReference>
    <dbReference type="GeneID" id="57878577"/>
    <dbReference type="KEGG" id="tpa:TP_0035"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093281" description="Probable metal transport system ATP-binding protein TP_0035">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="10"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="238" mass="26460" checksum="673E7B4882BE4D29" modified="1998-11-01" version="1">MRIMASPFAVLLQNVSFRYTADARFILHEVDLAIPKGAYLSVVGENGSGKSTLVKLVLKLLKPSTGTIAHFVQRVGSVPQTKMHTLYFPLTVYEMLNSYRRLLRISHKWVVDAVLEEVGMRGAKKKLVYTLSGGELQKVYIARSLIGDPDLLVLDELSTGIDSRGQKDIYALLKGLNTSRNVTVISVEHNLDAAITNSTQIFHLSEGHGHLCNPQQYVSEFLDMQKKDALACAQCRSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83079</accession>
    <name>Y036_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable metal transport system membrane protein TP_0036</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0036</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71375">
        <property type="entry name" value="F71375"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881485.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83079"/>
    <dbReference type="SMR" id="O83079"/>
    <dbReference type="IntAct" id="O83079">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0036"/>
    <dbReference type="EnsemblBacteria" id="AAC65031">
        <property type="protein sequence ID" value="AAC65031"/>
        <property type="gene ID" value="TP_0036"/>
    </dbReference>
    <dbReference type="GeneID" id="57878578"/>
    <dbReference type="KEGG" id="tpa:TP_0036"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_12"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000171175" description="Probable metal transport system membrane protein TP_0036">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="266" mass="28383" checksum="7D2DA9D0A9E76638" modified="1998-11-01" version="1">MLQYAFMRNAFVASFLIALLCPLVGMHLVLRRYALMGDALAHGSLAGVSIAVSCGIHPGWGSFFFTALVGVLIEFLRAFFKNHHDLILSIVLSLSVGIAVTLLSSGLIQADIDSYLFGSILVVSTRDLWIMLALSVFCVGTLALRYHQLLYLAFDEETARICGVAADGINYVASVVISATIAASIKITGILVLSSLMTVPVATALQLRVGFLLTLVAAFLFSMLDTALGLVFSYYLNVAPGGFTALVSVVVLMLVIALTQVGRART</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83082</accession>
    <name>Y041_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0041</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0041</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71373">
        <property type="entry name" value="H71373"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83082"/>
    <dbReference type="IntAct" id="O83082">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65041">
        <property type="protein sequence ID" value="AAC65041"/>
        <property type="gene ID" value="TP_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0041"/>
    <dbReference type="HOGENOM" id="CLU_3349904_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202181" description="Uncharacterized protein TP_0041">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="40" mass="4391" checksum="EEDB3D96FEECB9B4" modified="1998-11-01" version="1">MNRMLSLSVQSQRAPASPSPYGLKIDKRVSPDYARAGVRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83090</accession>
    <name>RF1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Peptide chain release factor 1</fullName>
            <shortName>RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">prfA</name>
        <name type="ordered locus">TP_0051</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71372">
        <property type="entry name" value="E71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881500.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83090"/>
    <dbReference type="SMR" id="O83090"/>
    <dbReference type="IntAct" id="O83090">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0051"/>
    <dbReference type="EnsemblBacteria" id="AAC65047">
        <property type="protein sequence ID" value="AAC65047"/>
        <property type="gene ID" value="TP_0051"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0051"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_12"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177764" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="351" mass="40194" checksum="6993C6F883B5797C" modified="1998-11-01" version="1">MIEKLEELRAQWRKLQQEVENPSLFSSTQSYRERMRDHAYLSRLMEEYDRYLLTEKQLEDAHVLIQDESDADFKDVIRQEIRTLEAALHTSQKRLKTLLIPPDSLQEKNIIMEIRGGTGGDEAALFAADLFRMYTHYAESKQWRYEVLAVSETELGGFKEITFSISGRDVYGSLRYESGVHRVQRVPSTEASGRIHTSAVTVAVLPEMEETEVDIRAEDVRVDVMRASGPGGQCVNTTDSAVRLTHLPTGIVVVCQDEKSQIKNKAKAMRVLRSRVYDLEESKRQVARARERKSQVGSGDRSERIRTYNFPQNRVTDHRVRVTLYKLDAVMQGALDDIIEPLCIASRESVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83101</accession>
    <name>SSB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="1">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ssb</name>
        <name type="ordered locus">TP_0062</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71370">
        <property type="entry name" value="F71370"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881511.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83101"/>
    <dbReference type="SMR" id="O83101"/>
    <dbReference type="IntAct" id="O83101">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0062"/>
    <dbReference type="EnsemblBacteria" id="AAC65057">
        <property type="protein sequence ID" value="AAC65057"/>
        <property type="gene ID" value="TP_0062"/>
    </dbReference>
    <dbReference type="GeneID" id="57878602"/>
    <dbReference type="KEGG" id="tpa:TP_0062"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_0_1_12"/>
    <dbReference type="OMA" id="GNCIGRF"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000096130" description="Single-stranded DNA-binding protein">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SSB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="176" mass="19043" checksum="47C49D2F79927D2C" modified="1998-11-01" version="1">MADVNHVVLVGRLTRDAELKYTSAGGALCRFSVAINRRRKSGDDWVEEVNFFDIVLWGRQGEVISQYLIKGKQVAVEGELRQSRWEQEGQSRSKVEISATNVQLLGSVLGGAARAEDGEFSSSRVAAESTAGRVRGTSSDSRSPTGDILGEKRGLDATSSLDEADFSSSDLDTVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83116</accession>
    <name>O83116_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Capsular polysaccharide biosynthesis protein (Cap5D)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71369">
        <property type="entry name" value="D71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881526.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83116">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0077"/>
    <dbReference type="EnsemblBacteria" id="AAC65072">
        <property type="protein sequence ID" value="AAC65072"/>
        <property type="gene ID" value="TP_0077"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75296">
        <property type="protein sequence ID" value="AGN75296"/>
        <property type="gene ID" value="TPANIC_0077"/>
    </dbReference>
    <dbReference type="GeneID" id="57878617"/>
    <dbReference type="KEGG" id="tpa:TP_0077"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.77"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_12"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="188"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="538" mass="59305" checksum="650BC5A87D8DEB00" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83125</accession>
    <name>O83125_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71367">
        <property type="entry name" value="H71367"/>
    </dbReference>
    <dbReference type="IntAct" id="O83125">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0087"/>
    <dbReference type="EnsemblBacteria" id="AAC65082">
        <property type="protein sequence ID" value="AAC65082"/>
        <property type="gene ID" value="TP_0087"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75306">
        <property type="protein sequence ID" value="AGN75306"/>
        <property type="gene ID" value="TPANIC_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0087"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.87"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_0_2_12"/>
    <dbReference type="OMA" id="FWMYQTL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="179" mass="20083" checksum="E7B387E4B2F90F64" modified="1998-11-01" version="1">MYKAFEEHVSFYLHRTPAALSLLLLGLLSCVACRTNSLETAQIAFCTGGQYVPVVVELALTEEAQRRGYMGRTRIPDGTGMLFVYKQDTRLSFWMKDTPHPLSLAFLDAQGAIVQIEDLVPLSTHSVRSNRSVRYALEVPRGWFVRSKLLVGARLSARSLARIRRHADPPKGQSGDKRH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>O83128</accession>
    <name>MURB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber>1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">murB</name>
        <name type="ordered locus">TP_0090</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71368">
        <property type="entry name" value="C71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881539.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83128"/>
    <dbReference type="SMR" id="O83128"/>
    <dbReference type="STRING" id="243276.TPANIC_0090"/>
    <dbReference type="EnsemblBacteria" id="AAC65086">
        <property type="protein sequence ID" value="AAC65086"/>
        <property type="gene ID" value="TP_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0090"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_12"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179282" description="UDP-N-acetylenolpyruvoylglucosamine reductase">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type">
        <location>
            <begin position="26"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Insert">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="354" mass="38595" checksum="809E56E606F5BFF2" modified="1998-11-01" version="1">MSAHRIRARRITRRNVPLAERCSFRIGGAAQFWAEPRSCTQLRALIEEAQRARIPLSLIGGGSNVLIADEGVPGLMLSLRRFRSLHTQTQRDGSVLVHAGAGLPVAALLAFCAHHALRGLETFAGLPGSVGGAAYMNARCYGRAIADCFHSARTLVLHPVRSRAKELPEVRKNAQDKRGECLGLDGGPFTCSSFQTVFARAGDWGYKRSPFQSPHGVELHAGRRLILSLCVRLTPGNPAQIRKHMQEKIADRISKGQFRFPSAGSAFKNNPAFGKPSGILIEEAGLRGTSCGAAQVAPWHGNLIINTGNATAHQVRTLLRVVRQRVFETHGVWLEREIIFSGESVRMTSSSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83134</accession>
    <name>O83134_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaK suppressor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71366">
        <property type="entry name" value="D71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881545.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0096"/>
    <dbReference type="EnsemblBacteria" id="AAC65091">
        <property type="protein sequence ID" value="AAC65091"/>
        <property type="gene ID" value="TP_0096"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75315">
        <property type="protein sequence ID" value="AGN75315"/>
        <property type="gene ID" value="TPANIC_0096"/>
    </dbReference>
    <dbReference type="GeneID" id="57878636"/>
    <dbReference type="KEGG" id="tpa:TP_0096"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.96"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_4_1_12"/>
    <dbReference type="OMA" id="CIDCKEE"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13580" checksum="41709507D12B3548" modified="1998-11-01" version="1">MDQSFVEEMKVSLVERKRSLARSLTTNNEDFQAIVAGVDPKDSADIASDDMDRKMLESLSAKDLRCLQQIESALLRIEQGRYGKCADCGESIPEDRLRAIPYSLMCIECQSARESKRRAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83154</accession>
    <name>UVRB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein B</fullName>
            <shortName evidence="1">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrB</name>
        <name type="ordered locus">TP_0116</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71365">
        <property type="entry name" value="C71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881565.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83154"/>
    <dbReference type="SMR" id="O83154"/>
    <dbReference type="STRING" id="243276.TPANIC_0116"/>
    <dbReference type="EnsemblBacteria" id="AAC65106">
        <property type="protein sequence ID" value="AAC65106"/>
        <property type="gene ID" value="TP_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0116"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_12"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138442" description="UvrABC system protein B">
        <location>
            <begin position="1"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="431"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <sequence length="668" mass="76190" checksum="B4C79EC870C244E5" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83161</accession>
    <name>O83161_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="6" type="ordered locus">TP_0124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71364">
        <property type="entry name" value="C71364"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881573.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83161">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0124"/>
    <dbReference type="EnsemblBacteria" id="AAC65113">
        <property type="protein sequence ID" value="AAC65113"/>
        <property type="gene ID" value="TP_0124"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75343">
        <property type="protein sequence ID" value="AGN75343"/>
        <property type="gene ID" value="TPANIC_0124"/>
    </dbReference>
    <dbReference type="GeneID" id="57878667"/>
    <dbReference type="KEGG" id="tpa:TP_0124"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.126"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_018395_0_1_12"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="368" mass="40490" checksum="27C7A11708CB2698" modified="1998-11-01" version="1">MAVNCGIIGLPNVGKSTIFSALTANVVEAANYPFCTIEPNVGMVTVPDVRLEALAGHFRPKKTVYASIECVDIAGLVKGASQGEGLGNRFLAHVREVGVLAHVVRCFEHTDIVHVHNKVDPLSDIETVHIELALADLASVEKRAVRAQKESRMGKSLQKESTLVLRALDTLREYLEMGKAACMAPLSDEERNAVRDMRLLTMKPHLYVCNTDESGMQYGNDFVRAVQEHARVHNTQAIVMCGKFEAELAQLSDVAEQNAFLQELGLRESGRAALARAVYSLMGLRTFFTAGPEECRAWTIRAGLRAPHAAGVIHSDLERGFIRAETYSFDDLASCGSVAKVREANRVRQEGKEYEVQDGDVIFFKFNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83165</accession>
    <name>Y128_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0128</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0128</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71362">
        <property type="entry name" value="E71362"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881577.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83165"/>
    <dbReference type="IntAct" id="O83165">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0128"/>
    <dbReference type="EnsemblBacteria" id="AAC65120">
        <property type="protein sequence ID" value="AAC65120"/>
        <property type="gene ID" value="TP_0128"/>
    </dbReference>
    <dbReference type="GeneID" id="57878672"/>
    <dbReference type="KEGG" id="tpa:TP_0128"/>
    <dbReference type="HOGENOM" id="CLU_2412296_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202194" description="Uncharacterized protein TP_0128">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <sequence length="115" mass="11764" checksum="3E4B3C3E78A109ED" modified="1998-11-01" version="1">MEFLRATASREVDVNSGWGYGSGVERGFLCEGDVRACLVPASHFVRAGTAPGTTPGTAAACLFVPPYVLGVTPAGTLPFGLPSQSVLGGLRLAPVHASSLLEGLGATIFFRCNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83182</accession>
    <name>O83182_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71361">
        <property type="entry name" value="D71361"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881594.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0147"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65134">
        <property type="protein sequence ID" value="AAC65134"/>
        <property type="gene ID" value="TP_0147"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75366">
        <property type="protein sequence ID" value="AGN75366"/>
        <property type="gene ID" value="TPANIC_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0147"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.159"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026700_0_0_12"/>
    <dbReference type="OMA" id="HFMSAGL"/>
    <dbReference type="OrthoDB" id="94039at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015179">
        <property type="entry name" value="A-amylase/a-glucTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09095">
        <property type="entry name" value="DUF1926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1926" evidence="2">
        <location>
            <begin position="443"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="619" mass="70406" checksum="1FDAF4D80379B94B" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83194</accession>
    <name>Y159_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0159</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0159</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71359">
        <property type="entry name" value="E71359"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881606.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83194"/>
    <dbReference type="STRING" id="243276.TPANIC_0159"/>
    <dbReference type="EnsemblBacteria" id="AAC65152">
        <property type="protein sequence ID" value="AAC65152"/>
        <property type="gene ID" value="TP_0159"/>
    </dbReference>
    <dbReference type="GeneID" id="57878702"/>
    <dbReference type="KEGG" id="tpa:TP_0159"/>
    <dbReference type="eggNOG" id="ENOG502ZZH4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787408_0_0_12"/>
    <dbReference type="OMA" id="SMETAGH"/>
    <dbReference type="OrthoDB" id="1752429at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014240" description="Uncharacterized protein TP_0159">
        <location>
            <begin position="21"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="342" mass="39243" checksum="9A1C5A7AEA715C67" modified="1998-11-01" version="1" precursor="true">MYIKVALVCLFSMGARCLLATEPAPVSGDYVLYRDYSWKSPTWVGFLCYDAHTYGALLCTPAESRRITILFTGTEKHGRFELTGQRITSPVRTEDLTGINYLMDLFPQLQRWKHFPRDTHTLVARHTDRSKKSTQFSGAVELQFASFVPLFHLEILRDKQQRVMLQLSEIGKIDHTSDAAFFQFTPMPPSTPTDAPPATLNQTLTRTEYVIDDVCIALDPQWKRIAENSFLSDFAFLTVHQVPAPRAHDYSALRALLQLFLYSGPQGKNILEQLHINDTHARLTLSYAVFDLPSKTVKKTWKIFIRHSDTHYSILSLTADQRTAQRYARYFDTLIETIRTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>O83215</accession>
    <name>O83215_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal peptidase I</fullName>
            <ecNumber evidence="2">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71354">
        <property type="entry name" value="C71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881632.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83215">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0185"/>
    <dbReference type="EnsemblBacteria" id="AAC65170">
        <property type="protein sequence ID" value="AAC65170"/>
        <property type="gene ID" value="TP_0185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75399">
        <property type="protein sequence ID" value="AGN75399"/>
        <property type="gene ID" value="TPANIC_0185"/>
    </dbReference>
    <dbReference type="GeneID" id="57878723"/>
    <dbReference type="KEGG" id="tpa:TP_0185"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.187"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_3_0_12"/>
    <dbReference type="OMA" id="RTWGPVP"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26880" checksum="61FCDA9620131512" modified="1998-11-01" version="1">MFARWRRYSYLARREARRNATAVCSAGVGFFLFYLFITTHVVAAYRIQADSMQPTLSAGDCVLASSLFRFARIKRGDLVLATPLEKEDIGLFKRAMNAVLGFASLQLYRPFGAADRMFSRPQMRRVVGLPGDTVYMRDFVLYVKPHGQQHFLTEFEVSAVSYDVRKGVLPEHWSERLPFSGFMEEMQLDEHSYFVLCDNRIVSSDSRLWGAIDGSTQIKAKAFMRYFPFGAFGVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83239</accession>
    <name>RL36_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="ordered locus">TP_0209</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71351">
        <property type="entry name" value="G71351"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881657.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83239"/>
    <dbReference type="SMR" id="O83239"/>
    <dbReference type="IntAct" id="O83239">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65209">
        <property type="protein sequence ID" value="AAC65209"/>
        <property type="gene ID" value="TP_0209"/>
    </dbReference>
    <dbReference type="GeneID" id="57878747"/>
    <dbReference type="KEGG" id="tpa:TP_0209"/>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000126288" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4338" checksum="AF2B259BFB474B36" modified="1998-11-01" version="1">MKIRTSVKVICDKCKLIKRFGIIRVICVNPKHKQRQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83245</accession>
    <name>GRPE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">TP_0215</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71352">
        <property type="entry name" value="E71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881663.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83245"/>
    <dbReference type="SMR" id="O83245"/>
    <dbReference type="STRING" id="243276.TPANIC_0215"/>
    <dbReference type="EnsemblBacteria" id="AAC65203">
        <property type="protein sequence ID" value="AAC65203"/>
        <property type="gene ID" value="TP_0215"/>
    </dbReference>
    <dbReference type="GeneID" id="57878753"/>
    <dbReference type="KEGG" id="tpa:TP_0215"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_12"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000113887" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="220" mass="24207" checksum="DD51E4E45FAA1BB6" modified="1998-11-01" version="1">MCGGDVQGQGVASGCDEALERADSLRASDPVPVESGEGSVPGEHSQELETGASEETLRERVNVLQEQYLRKAADLENYRKRALRERQEAVEHAYAALLADIVAVLDDFDRAIEAADHASSTEVEASSAFREGVLMIRKQLSSVLETKYGLEYYPVLGERFDPNLHEALSMSPSASVHEKIVGAELQKGYRVRNRILRHAKVMVLTPEEQTEPDRGDGPSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83246</accession>
    <name>DNAK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">dnaK</name>
        <name type="ordered locus">TP_0216</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71352">
        <property type="entry name" value="F71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881664.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83246"/>
    <dbReference type="SMR" id="O83246"/>
    <dbReference type="IntAct" id="O83246">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0216"/>
    <dbReference type="PRIDE" id="O83246"/>
    <dbReference type="EnsemblBacteria" id="AAC65204">
        <property type="protein sequence ID" value="AAC65204"/>
        <property type="gene ID" value="TP_0216"/>
    </dbReference>
    <dbReference type="GeneID" id="57878754"/>
    <dbReference type="KEGG" id="tpa:TP_0216"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_12"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000078577" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="635" mass="68042" checksum="11244A863A4504CD" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83284</accession>
    <name>Y260_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0260</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0260</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71347">
        <property type="entry name" value="A71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881709.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83284"/>
    <dbReference type="IntAct" id="O83284">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0260"/>
    <dbReference type="EnsemblBacteria" id="AAC65253">
        <property type="protein sequence ID" value="AAC65253"/>
        <property type="gene ID" value="TP_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0260"/>
    <dbReference type="eggNOG" id="ENOG5033XG8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628383_0_0_12"/>
    <dbReference type="OMA" id="NIKYLRP"/>
    <dbReference type="OrthoDB" id="440349at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202220" description="Uncharacterized protein TP_0260">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="105"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="448" mass="51247" checksum="F5DCAE035E30B5EB" modified="1998-11-01" version="1">MCYYRYVQVHSIWRRFCALGLLVPFLLLLFSCTNTVGYGVLQWSLPDLGLSTGDILPVYVRSNVSQVYIVEIQKKKVELPFWQLKLCRTKKEALQYAERLREYRYSYATSVLDGLPLREGPENTAPQVYRLREGQAVKLLWKGTGKAVYRGENRLEGDWFKVMTEDGTTGWCFSHGLSLFDERESRPTVRETDDLARDRDLQHVLNSAWYPEYYRTMVEQRRIDLEKMASGWGLFVGEKKGLARIELPDAHYAFPYSRLVKTGSNGYLFDGSSLSIYVRDAHTLAAQFTDEAGRLRIERFVTLEKTPEEIIAEEQLRRSALLEHVCTPGLRLHSEIYGTLSFTERNVFTWTGARALSPALIPAGAGSTGRVALRCFIDQSLKSEYEGVLSFDFDSAQEWVHFLYLRTPGGLKLEHIDSTHLKDATVLRRSVSPVVLYFAPEGHAEPQP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83296</accession>
    <name>SOJ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Protein Soj homolog</fullName>
            <ecNumber>3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0272</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ParA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71346">
        <property type="entry name" value="B71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881721.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83296"/>
    <dbReference type="SMR" id="O83296"/>
    <dbReference type="IntAct" id="O83296">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0272"/>
    <dbReference type="EnsemblBacteria" id="AAC65260">
        <property type="protein sequence ID" value="AAC65260"/>
        <property type="gene ID" value="TP_0272"/>
    </dbReference>
    <dbReference type="GeneID" id="57878816"/>
    <dbReference type="KEGG" id="tpa:TP_0272"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_12"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000201982" description="Protein Soj homolog">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="253" mass="27342" checksum="284B3B31A9306EDA" modified="1998-11-01" version="1">MGKTLVFVNQKGGVGKTTSAINLGAYLALAGKKTLLVDFDPQGNMSSGLGLARGLTVYDLLAGKAHINSVLRTTPVHNLFAIPASIDLSGATVELVDEQDRELYLKKILAEVKDTYDFILIDCPPSLGILTLNGLAAANEVFIPLQCEYFALEGLTLLLQTVKRVQSGLNTALSIGGIFFTMYDTRTKLAQEVVKQVTTYFGDKVFNTIIPRNVKLSEAPSHGLPISSYDAQCAGARSYEKLAREIVARDGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83301</accession>
    <name>O83301_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxyl-terminal protease (Ctp)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71342">
        <property type="entry name" value="H71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881726.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0277"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="AAC65265">
        <property type="protein sequence ID" value="AAC65265"/>
        <property type="gene ID" value="TP_0277"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75488">
        <property type="protein sequence ID" value="AGN75488"/>
        <property type="gene ID" value="TPANIC_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="57878821"/>
    <dbReference type="KEGG" id="tpa:TP_0277"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.281"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_0_12"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="448" mass="50317" checksum="741BB0E930C7E7CE" modified="1998-11-01" version="1">MQTVQDVYEFLRKYYVDEVDPHILYKGALEGMINSLQDPYTTFVESDSISGVNLQDTTKGFFGGIGVVISKSRTSTPGKPAYVEVTAAIEDTPSWKGGIRPRDLIVKIGTMSTDTMTMDEVLKKLRGPIGTKVTLVVKRGTKIFRPFTLTRAKIEIPTVKYAKIDPNIAYVRLIEFNPVTATRMVETVTELRRQGCDRLILDLRNNPGGLITAAVDVTSSFIPSGTVVTTKSRVQGHSITFSVNARAQKLPPSMPVIVLINRDSASASEIVSGALKDHKRAYLVGQTTYGKGVVQQVFDLNERESLKMTISRYYTPSDANIDKSGIPPDLEVRETEFTPEEEEALVSLFKSEKVKLFAEQNRTMNSERIKQYARGLAREFKLRSILVEKLIAQEYHRHNASFVYDLEYDEQLRKAVELIRTQDIHALVARTKTVKELQEGIQEKKKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83313</accession>
    <name>O83313_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71344">
        <property type="entry name" value="D71344"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0288"/>
    <dbReference type="EnsemblBacteria" id="AAC65282">
        <property type="protein sequence ID" value="AAC65282"/>
        <property type="gene ID" value="TP_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0289"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015968_0_0_12"/>
    <dbReference type="OMA" id="DIITAWY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="534" mass="59551" checksum="60B7C9F61BF48959" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83319</accession>
    <name>COAE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name type="ordered locus">TP_0296</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71341">
        <property type="entry name" value="B71341"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881745.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83319"/>
    <dbReference type="SMR" id="O83319"/>
    <dbReference type="IntAct" id="O83319">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0296"/>
    <dbReference type="EnsemblBacteria" id="AAC65285">
        <property type="protein sequence ID" value="AAC65285"/>
        <property type="gene ID" value="TP_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="57878833"/>
    <dbReference type="KEGG" id="tpa:TP_0296"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_2_2_12"/>
    <dbReference type="OMA" id="DVDKEYH"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173026" description="Dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DPCK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="211" mass="23584" checksum="A20927A64D810789" modified="1998-11-01" version="1">MREFCPLIGVIGRSGAGKNVVSRLLAERGCYCIDADARTRELLESYGDSIVERFQVAAAARGLSLRRKDGGLHSAHLGVLLFSEPKLLQQHEEFLLPKVTRLLCEDIARAQAARPKAIVLNAPTLHKTELLQACSFVLYIWAPSILRMWRCKKRERVSFTHLLRRFSAQKGFYAQSIAQNADTYTVANCGRVASLARKVDCILTRRGVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83334</accession>
    <name>O83334_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71340">
        <property type="entry name" value="B71340"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881761.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83334">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0312"/>
    <dbReference type="EnsemblBacteria" id="AAC65299">
        <property type="protein sequence ID" value="AAC65299"/>
        <property type="gene ID" value="TP_0312"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75515">
        <property type="protein sequence ID" value="AGN75515"/>
        <property type="gene ID" value="TPANIC_0312"/>
    </dbReference>
    <dbReference type="GeneID" id="57878847"/>
    <dbReference type="KEGG" id="tpa:TP_0312"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.311"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_0_0_12"/>
    <dbReference type="OMA" id="PIPVWSF"/>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="337" mass="34712" checksum="DCE24908CF029815" modified="1998-11-01" version="1">MSSPVMHVWIGMLIGAANVVPGLSGGTVALLCGTWELLIAAIALDRAHLCRQWRRLLALAGGIVVGIGVCARFMRALYEAFPHLTNAFLAGVLLASVPSLRNRVRAASVAAEHSVQAEGTARGHVGDAARRVWCAVRIIFFVLLGFVAVCAFSRMQHARDASSATAPASVQTTAVLTTAHTRGFVATVCAGALAAAAMLTPGFSGSLVLLLAGVYQPLLSVLSLRAVEQGGGVTGASVISRLCSAHVWGLLFPLCVGMGIGLLGAARVLRAWFRLYPVSAHACVCGLVLGSSVTLFPRGTAAGMQDQFTLFMGCVAGCVGAFALAKVCAWGARDAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83335</accession>
    <name>O83335_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein E (TprE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71340">
        <property type="entry name" value="C71340"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881762.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83335">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0313"/>
    <dbReference type="EnsemblBacteria" id="AAC65300">
        <property type="protein sequence ID" value="AAC65300"/>
        <property type="gene ID" value="TP_0313"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75516">
        <property type="protein sequence ID" value="AGN75516"/>
        <property type="gene ID" value="TPANIC_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0313"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.312"/>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="96"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="559"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="762" mass="81543" checksum="80E065AF5A06F70F" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83343</accession>
    <name>O83343_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose/galactose ABC transporter, permease protein (RbsC-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71338">
        <property type="entry name" value="F71338"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881771.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0323"/>
    <dbReference type="TCDB" id="3.A.1.2.10">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65311">
        <property type="protein sequence ID" value="AAC65311"/>
        <property type="gene ID" value="TP_0323"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75523">
        <property type="protein sequence ID" value="AGN75523"/>
        <property type="gene ID" value="TPANIC_0323"/>
    </dbReference>
    <dbReference type="GeneID" id="57878855"/>
    <dbReference type="KEGG" id="tpa:TP_0323"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.322"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_2_12"/>
    <dbReference type="OMA" id="MIFGNWM"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="316" mass="33825" checksum="E774BE9C3DC5F0D9" modified="1998-11-01" version="1">MNTFYSMVALTLVFSTPILITALGGLFSERSGVINIALEGLMMFGAFSTATVTVLCEPYTIAAPWIALGVGMAVAASVALFYAYLSVRLCSDQIIAGTAINLCATGMTVFFAQVIFGQQGTQAYSRGLVKTSYGFFSRIPVLGPMVFTHTYPTVYLGFVLVALAWYVLYRTPFGVHVRATGDQPYAVDGAGLSVFRLRSAAVVISGLCAGLGGGVLILTQDIQYTVYSTHGTGFIALAALISGRWHPFGVLVTSVLFGFSQILNVYATSVELLKHLPIELFSALPYALTVVVLLLFGGRGEAPRAIGQPYDRARRY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83345</accession>
    <name>O83345_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71338">
        <property type="entry name" value="H71338"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65312">
        <property type="protein sequence ID" value="AAC65312"/>
        <property type="gene ID" value="TP_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0325"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.342"/>
    <dbReference type="HOGENOM" id="CLU_004913_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="988" mass="108468" checksum="2B0360D6D0696D7C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83355</accession>
    <name>Y335_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0335</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0335</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71337">
        <property type="entry name" value="E71337"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83355"/>
    <dbReference type="STRING" id="243276.TPANIC_0335"/>
    <dbReference type="EnsemblBacteria" id="AAC65328">
        <property type="protein sequence ID" value="AAC65328"/>
        <property type="gene ID" value="TP_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0335"/>
    <dbReference type="HOGENOM" id="CLU_1502848_0_0_12"/>
    <dbReference type="OMA" id="TSCTARV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202238" description="Uncharacterized protein TP_0335">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="180" mass="19219" checksum="5BB9C80BB334B48A" modified="1998-11-01" version="1">MAITTAGDICALYPLCPILLHCSTLMHLSPLRNTPHVLHAAAAVTEYAFVLSTLVFPSFCFSLPSPFPFPEGEGGAFYVRLFLNALSEEVLFRAYIPERLCHHATSCTARACGEVLSVLLFALAHRPAGSATLFAGAAGAALRVLFVREKKRSGSRARASALCTAVHALWNAYAIAAAAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83384</accession>
    <name>Y369_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0369</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0369</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71332">
        <property type="entry name" value="H71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881817.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83384"/>
    <dbReference type="SMR" id="O83384"/>
    <dbReference type="STRING" id="243276.TPANIC_0369"/>
    <dbReference type="EnsemblBacteria" id="AAC65360">
        <property type="protein sequence ID" value="AAC65360"/>
        <property type="gene ID" value="TP_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0369"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532002_0_0_12"/>
    <dbReference type="OMA" id="PTPHRQS"/>
    <dbReference type="OrthoDB" id="1779689at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014246" description="Uncharacterized protein TP_0369">
        <location>
            <begin position="18"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="516" mass="55860" checksum="1FBC37CE5A0F0CCF" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83397</accession>
    <name>Y382_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0382</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0382</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71330">
        <property type="entry name" value="H71330"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83397"/>
    <dbReference type="IntAct" id="O83397">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65383">
        <property type="protein sequence ID" value="AAC65383"/>
        <property type="gene ID" value="TP_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0382"/>
    <dbReference type="HOGENOM" id="CLU_3298110_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202247" description="Uncharacterized protein TP_0382">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <sequence length="40" mass="4104" checksum="1B74B6D9597CCC90" modified="1998-11-01" version="1">MGAAGKEGAQCQGGDVCELVRHRLTMQADVLESGGVCGRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83405</accession>
    <name>FTSZ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ftsZ</name>
        <name type="ordered locus">TP_0390</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71331">
        <property type="entry name" value="H71331"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881838.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83405"/>
    <dbReference type="SMR" id="O83405"/>
    <dbReference type="IntAct" id="O83405">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0390"/>
    <dbReference type="EnsemblBacteria" id="AAC65374">
        <property type="protein sequence ID" value="AAC65374"/>
        <property type="gene ID" value="TP_0390"/>
    </dbReference>
    <dbReference type="GeneID" id="57878916"/>
    <dbReference type="KEGG" id="tpa:TP_0390"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_12"/>
    <dbReference type="OMA" id="IMNQGGV"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000114392" description="Cell division protein FtsZ">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="418" mass="43839" checksum="40187993E34CADEE" modified="1998-11-01" version="1">MMNIELAPSGEEFTLSPTVIKVIGAGGGGSNAVNRMMSCGLQCVEFIAANTDVQALSYSTAPKKLAIGTKVTRGLGAGGDPEIGEKAAMEDAEAIASALQGANMVFITAGMGGGTGTGAAPVIAKIARELGALTVAVVTKPFRFEGRAKMMLAERGIEKLRTHSDTVIVIPNQNLLSVVDKRCPIKETYLVADDLLRKSVQSISDLITLPGEVNLDFMDVKNTMEGQGYALIGVGEGEGENRAVDAATAAINNPLLEETRIEGATRLLVAVRGSENLSMGEVDGVMSVVAKTIDPDAIIIHGTSIDASMQDRVRVTVIATGVPQASISIAGDTHSSQKIKTSSYGAVSTGVYISSDEWNRAKSSKQPNLPGLATRNSAVQETRMEKNGVKGHTFGVPLPSVNEDLDEPTFLRNRNKGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="145" xmlns="http://uniprot.org/uniprot">
    <accession>O83417</accession>
    <name>FLII_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellum-specific ATP synthase</fullName>
            <ecNumber>7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliI</name>
        <name type="ordered locus">TP_0402</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71329">
        <property type="entry name" value="A71329"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881850.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83417"/>
    <dbReference type="SMR" id="O83417"/>
    <dbReference type="IntAct" id="O83417">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0402"/>
    <dbReference type="EnsemblBacteria" id="AAC65390">
        <property type="protein sequence ID" value="AAC65390"/>
        <property type="gene ID" value="TP_0402"/>
    </dbReference>
    <dbReference type="GeneID" id="57878928"/>
    <dbReference type="KEGG" id="tpa:TP_0402"/>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_5_1_12"/>
    <dbReference type="OMA" id="MLMMDSV"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022426">
        <property type="entry name" value="FliI_clade3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03498">
        <property type="entry name" value="FliI_clade3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144699" description="Flagellum-specific ATP synthase">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="447" mass="47852" checksum="A4D3BED88A337686" modified="1998-11-01" version="1">MEADLLCKYEVALRESEPVKYVGHVTAVRGLLIESRGPHAVVGELCRIVLRRQGRPLIAEVVGLAGSTVKLMSYTDTHGVEVGCAVVAEGAALSVPVGDALLGRVLNAFGKAIDGKGEIYAPLRSEVLRASSNPMERLPITRQMVTGVRVLDSLLAVGCGQRLGIFSGSGVGKSTLMGMIARNTDADVSVIALIGERGREVMDFVAHDLGPEGLKRSVIVSATSDESPLARVRGAYTATAIAEYFRDQGKQVLLLFDSLTRFAKAQREIGLASGELPATRGYTPGVFETLPKLLERAGSFSMGSVTAFYTVLVDGDDLDEPISDAVRGIVDGHIVLSRALAQRNHYPAIDVLQSVSRLAHRVLGADMKEAVRIVRRALAVYAEVEDLVRVGAYQQGSDAELDRAIAMRAELERFLTQGAQERVRFQDTVTSLSMLTGLSIAQPPSGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83425</accession>
    <name>SECD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secD</name>
        <name type="ordered locus">TP_0410</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71326">
        <property type="entry name" value="H71326"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881858.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83425"/>
    <dbReference type="SMR" id="O83425"/>
    <dbReference type="IntAct" id="O83425">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0410"/>
    <dbReference type="EnsemblBacteria" id="AAC65398">
        <property type="protein sequence ID" value="AAC65398"/>
        <property type="gene ID" value="TP_0410"/>
    </dbReference>
    <dbReference type="GeneID" id="57878936"/>
    <dbReference type="KEGG" id="tpa:TP_0410"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_3_12"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000095973" description="Protein translocase subunit SecD">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <sequence length="583" mass="63861" checksum="9A787E64C4CFE1A1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-02-23" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83432</accession>
    <name>LNT2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apolipoprotein N-acyltransferase 2</fullName>
            <shortName evidence="1">ALP N-acyltransferase 2</shortName>
            <ecNumber evidence="1">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lnt2</name>
        <name type="ordered locus">TP_0417</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71327">
        <property type="entry name" value="G71327"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881865.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0417"/>
    <dbReference type="PRIDE" id="O83432"/>
    <dbReference type="EnsemblBacteria" id="AAC65404">
        <property type="protein sequence ID" value="AAC65404"/>
        <property type="gene ID" value="TP_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0417"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_1_12"/>
    <dbReference type="OMA" id="YVALVPW"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178106" description="Apolipoprotein N-acyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="221"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <sequence length="559" mass="61262" checksum="ADE09DF055713F7E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83435</accession>
    <name>Y420_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0420</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0420</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71328">
        <property type="entry name" value="B71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881868.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83435"/>
    <dbReference type="IntAct" id="O83435">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65408">
        <property type="protein sequence ID" value="AAC65408"/>
        <property type="gene ID" value="TP_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0420"/>
    <dbReference type="HOGENOM" id="CLU_2670013_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202251" description="Uncharacterized protein TP_0420">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <sequence length="75" mass="8256" checksum="D01376B1670F383B" modified="1998-11-01" version="1">MRRRIYEERGAVRQAGLAHVFEYQGGAAHTGAVQDSDWAVVMRGDIAITLVYAQPVSMPPVLPLPDFAFQACCSY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83453</accession>
    <name>CHEW_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chemotaxis protein CheW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cheW</name>
        <name type="ordered locus">TP_0439</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71323">
        <property type="entry name" value="G71323"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83453"/>
    <dbReference type="SMR" id="O83453"/>
    <dbReference type="IntAct" id="O83453">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0439"/>
    <dbReference type="EnsemblBacteria" id="AAC65426">
        <property type="protein sequence ID" value="AAC65426"/>
        <property type="gene ID" value="TP_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0439"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_12"/>
    <dbReference type="OMA" id="CVNIMSV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000198350" description="Chemotaxis protein CheW">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00052"/>
        </source>
    </evidence>
    <sequence length="170" mass="19124" checksum="DE721FFE78BA9C4A" modified="1998-11-01" version="1">MYHGPTLHHRRVPMAVNDEQFQLVTFQLGEELYGIDIMGVKEIVKVQDVRPIPCAPAYVEGIFNLRSEIIPIINLHKRFHLREATLESGDEYLGGFVILNVEDSKLGIIIDRIARVIAVSQEDVQSPPQVITGIGAEYIHGVVRQGTSYLIVLDIHKLFSSKELQKLANL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83454</accession>
    <name>O83454_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat polysaccharide biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71323">
        <property type="entry name" value="H71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881888.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0440"/>
    <dbReference type="EnsemblBacteria" id="AAC65427">
        <property type="protein sequence ID" value="AAC65427"/>
        <property type="gene ID" value="TP_0440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75633">
        <property type="protein sequence ID" value="AGN75633"/>
        <property type="gene ID" value="TPANIC_0440"/>
    </dbReference>
    <dbReference type="GeneID" id="57878964"/>
    <dbReference type="KEGG" id="tpa:TP_0440"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.438"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_2_0_12"/>
    <dbReference type="OMA" id="GVAFREY"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="383" mass="41711" checksum="C55A6DCE8BFB5B79" modified="1998-11-01" version="1">MDAVLTCLVDEKIGPGSLGSTLIQLVREVFSPIDAYVLRSPAIALSFALRALKLPPASPVLLSALAPFWHYREVLHQGLQPLVLDVDIHSGLLSRDVVETGIARGARALLVPETLGNVPPAAVFLELGIPVIEDSSQSVGAVLGEKKVGTFGSCVIVGLEAHDMLTAGGGAVLMAFEAACARRLQALVPEALAVDMLPDMNAALACVQVKQQEKNIALRRAIYDRYSSALLRTRHGTLHRCEQLEHSAYAFPVVLASDLKEVTRYVRQASIEISPAFEHSIVAAFQLPAMRRRWPFPQFLPTSASHTAPFQGEDREVLETTQGAEKTCQDSSWEREVRASEITPEMCWPHASALLLRCVRFPLYPRLAPAHAQEIARILGTLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83460</accession>
    <name>ISPG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="1">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispG</name>
        <name type="ordered locus">TP_0446</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71324">
        <property type="entry name" value="F71324"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83460"/>
    <dbReference type="SMR" id="O83460"/>
    <dbReference type="IntAct" id="O83460">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0446"/>
    <dbReference type="EnsemblBacteria" id="AAC65433">
        <property type="protein sequence ID" value="AAC65433"/>
        <property type="gene ID" value="TP_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0446"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_12"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000190648" description="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <sequence length="404" mass="43734" checksum="7B594D44551DB716" modified="1998-11-01" version="1">MDSSAGVSPCNSPYGSGLLDVPLKLRPRASHYRARSLVIGGKEHVRALPLGGDAPIPIQTMWKEPLIGADLQSIVDRLLELEQLGCDVVRFAVPDRESAELFVALCARTRMPLVADIHFDYRLALRCMDGPVAKVRINPGNIGVRERVRAVVEKARATGTALRIGVNTGSLPGVVKRAVAARYADGMQSVNARAEALVQTAFAEAAYLDQLHFDRVVLSLKASTVAETVRANELFAQQSDIPLHLGVTEAGPLVSGIVKSTLAFSQLLSRNIGATVRVSLSDSMEHEVLAAREILAECGKRAGGVRLVSCPRCGRIGFDVHAFVRRWQKELFSLKKDITVAVMGCVVNGPGEGKHADLGISGAEDSVIFFKRGKIVRRIQVRDLCADERTRIIDAAFKEELSSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83500</accession>
    <name>Y487_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0487</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0487</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71317">
        <property type="entry name" value="G71317"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881936.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83500"/>
    <dbReference type="IntAct" id="O83500">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0487"/>
    <dbReference type="PRIDE" id="O83500"/>
    <dbReference type="EnsemblBacteria" id="AAC65482">
        <property type="protein sequence ID" value="AAC65482"/>
        <property type="gene ID" value="TP_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0487"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.520"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518683_0_0_12"/>
    <dbReference type="OMA" id="CKNARIF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202266" description="Uncharacterized protein TP_0487">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="525" mass="57071" checksum="38259325C96D7567" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83510</accession>
    <name>O83510_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">TP_0497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71316">
        <property type="entry name" value="E71316"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881946.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83510">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0497"/>
    <dbReference type="EnsemblBacteria" id="AAC65484">
        <property type="protein sequence ID" value="AAC65484"/>
        <property type="gene ID" value="TP_0497"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75687">
        <property type="protein sequence ID" value="AGN75687"/>
        <property type="gene ID" value="TPANIC_0497"/>
    </dbReference>
    <dbReference type="GeneID" id="57879018"/>
    <dbReference type="KEGG" id="tpa:TP_0497"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.493"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_12"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="344" mass="37058" checksum="2A552F21AB010BB1" modified="1998-11-01" version="1">MFFLRRFSADVGIDLGTCNTIIYVEGRGIVVNEPSVVAVERGTKSVVAVGSDAKRMLWKTPGNIVAIRPLKDGVIADMDTTEKMIRYFISKILPRHRLIKPRMVIGIPSCITDVECRAVHESASKAGAGEVEVLEESLAAAIGANIPIEEPAGNMVCDIGGGTTEVSVISLLGMVVTNAIRVGGDEFDQAIIKHVRSVHNLIIGEQTAERLKIEIGNASPEKNIEKVEVKGTDAITGLPRRLEIDSVEVREALKEPITQIVEEIKRTLARTPPELAADIVERGIVMTGGGSLLKGLPKLISKETHVPVILAENPMNCVAIGAGRYHEVYKDISGDRSLYAGLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83511</accession>
    <name>O83511_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71316">
        <property type="entry name" value="F71316"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881947.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83511">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0498"/>
    <dbReference type="EnsemblBacteria" id="AAC65485">
        <property type="protein sequence ID" value="AAC65485"/>
        <property type="gene ID" value="TP_0498"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75688">
        <property type="protein sequence ID" value="AGN75688"/>
        <property type="gene ID" value="TPANIC_0498"/>
    </dbReference>
    <dbReference type="GeneID" id="57879019"/>
    <dbReference type="KEGG" id="tpa:TP_0498"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.494"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_0_12"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32334" checksum="3F5D51CC48B57B33" modified="1998-11-01" version="1">MEKAFFFRIDSDLFTFIVFLLVSSGLLVFSGGELIVSFRDVGFSVTSRVEKAAASVSFFVTHTVKTLKTLSEVQRRYEVLREQLKDYEFLQGSRESLRKENQRLRAMLGFSRELSTRNIPAEIIGFDPDNLYSGIVVSRGARHGVRKNMPVVAFQSDTLGLVGKVVQVSRTTSMIVPLYHYQFYVAGKLERAQYRGLISGQGGSDFPLLMRYVKKHGQGSIRVGDLVVTSGENYPFPKDVPVGKVRDIKLHDHETSLELSLDPVLDLFRLEYVFILDLSLSQEGPHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O83536</accession>
    <name>LON_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon protease</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lon</name>
        <name type="ordered locus">TP_0524</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71316">
        <property type="entry name" value="B71316"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881972.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83536"/>
    <dbReference type="SMR" id="O83536"/>
    <dbReference type="STRING" id="243276.TPANIC_0524"/>
    <dbReference type="EnsemblBacteria" id="AAC65510">
        <property type="protein sequence ID" value="AAC65510"/>
        <property type="gene ID" value="TP_0524"/>
    </dbReference>
    <dbReference type="GeneID" id="57879047"/>
    <dbReference type="KEGG" id="tpa:TP_0524"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_12"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000076146" description="Lon protease">
        <location>
            <begin position="1"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="679"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="767"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="440"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="881" mass="97728" checksum="7D1905CD4920B504" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83546</accession>
    <name>Y535_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0535</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0535</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71313">
        <property type="entry name" value="H71313"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881982.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83546"/>
    <dbReference type="SMR" id="O83546"/>
    <dbReference type="STRING" id="243276.TPANIC_0535"/>
    <dbReference type="EnsemblBacteria" id="AAC65521">
        <property type="protein sequence ID" value="AAC65521"/>
        <property type="gene ID" value="TP_0535"/>
    </dbReference>
    <dbReference type="GeneID" id="57879059"/>
    <dbReference type="KEGG" id="tpa:TP_0535"/>
    <dbReference type="HOGENOM" id="CLU_2756626_0_0_12"/>
    <dbReference type="OMA" id="AQRMCES"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202271" description="Uncharacterized protein TP_0535">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <sequence length="70" mass="7879" checksum="D5CB56306A927239" modified="1998-11-01" version="1">MRESAEAAGETLVKEAEGSVVEAQEQAWHEACARIDAQRREACGQLERELSVLEEDVERFEAFLDGFFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83573</accession>
    <name>O83573_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat polysaccharide biosynthesis protein (SpsE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71307">
        <property type="entry name" value="H71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882009.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83573">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0562"/>
    <dbReference type="EnsemblBacteria" id="AAC65539">
        <property type="protein sequence ID" value="AAC65539"/>
        <property type="gene ID" value="TP_0562"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75749">
        <property type="protein sequence ID" value="AGN75749"/>
        <property type="gene ID" value="TPANIC_0562"/>
    </dbReference>
    <dbReference type="GeneID" id="57879088"/>
    <dbReference type="KEGG" id="tpa:TP_0562"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.559"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040465_0_0_12"/>
    <dbReference type="OMA" id="YRHRVEF"/>
    <dbReference type="OrthoDB" id="674753at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFP-like" evidence="1">
        <location>
            <begin position="312"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="378" mass="40533" checksum="6F91E7E8F4618958" modified="1998-11-01" version="1">MFTCGGRCFRPDADILTIAEIGSAHAGSFDRARALIDAAADAAAAAVKFQLIYAHEILHPLTGAVRLPSGAVSLYQRFEELEVPLSFYAQCFNHARSRGMLVGISPFGPRSATEALALKPDFLKVASPELNYPTLISTLAAAELPLILSSGVCLLKEIEGALAQCRQYTKQGSSHALLHCITAYPAPETEYNLALLPALATIFNINVGVSDHSVDPLLVPLLARAHGACIVEKHICLSRTDAGLDDSIALDPADFRTMTAALNSCARRSPSQIISFLHERGYAPHVVRAVIGSGEKVLAPSERAHYQKSNRSLHYLHAYPRGTVLQKENLVIVRSEANLSAGEAPEHANLFVGAVLQRSVHAGEGARFGDIIQKGTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83591</accession>
    <name>O83591_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71307">
        <property type="entry name" value="D71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882028.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83591">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0582"/>
    <dbReference type="EnsemblBacteria" id="AAC65556">
        <property type="protein sequence ID" value="AAC65556"/>
        <property type="gene ID" value="TP_0582"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75768">
        <property type="protein sequence ID" value="AGN75768"/>
        <property type="gene ID" value="TPANIC_0582"/>
    </dbReference>
    <dbReference type="GeneID" id="57879105"/>
    <dbReference type="KEGG" id="tpa:TP_0582"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.578"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_12"/>
    <dbReference type="OMA" id="ERTQMIG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503422" evidence="7">
        <location>
            <begin position="23"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="67"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="357"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="495" mass="54133" checksum="28BA6B9D1469FBAA" modified="1998-11-01" version="1">MKQRCAAVNLIRVIFMCALRCAGVCAGYGHTPSLHGDAHHVLPTPVPFLSGTPVAGKRRSFLRKSFFCAALGIGISIIPLIVVLVVSDGMIEGITTRMIELGSGHLQFIDILPLAPNETATQRYEDAQRIFNAFMAQDFGPYCHSRWMHLQGDGIVIGKTGRAGGNIRAVPPDFFSSERGLRPFLTVEGSLELVDRPQGVHTLILGKRIAERIGVRCGDTCQILTLVQGGTGRAVPKMVRAVVGGIVSCGYQELDALWVFIPLTLGMKILSPASALLSFVVKTADAFDAKAMTRFIEQVHEQLPSHFSAYTWQDMNRSQFHSFRTSRKLLLFIMYLIVLVASVHISSVLVVLMTERRKEIAMLKAMGAPPHVIALIFLSAGLLTALYGLLIGLPLGMWCAIHVNEMFLFAEQMLNSWRTAIHAIGQLFLRTSAHVPVTPIHLLDPAHYLERIPIVLSVHALCGVAGGTLCLSLAVCIIPALRAGRVRPLDLMRKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83628</accession>
    <name>Y619_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0619</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0619</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To T.pallidum TP_0127, TP_0315 and TP_0618.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71301">
        <property type="entry name" value="D71301"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83628"/>
    <dbReference type="IntAct" id="O83628">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0619"/>
    <dbReference type="EnsemblBacteria" id="AAC65602">
        <property type="protein sequence ID" value="AAC65602"/>
        <property type="gene ID" value="TP_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0619"/>
    <dbReference type="HOGENOM" id="CLU_091716_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202290" description="Uncharacterized protein TP_0619">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="270" mass="28911" checksum="2705DECC1E8656C4" modified="1998-11-01" version="1">MRGCRVGQRTGTVGVRVFPVGLCALSLQARDCRGMCGKRLGKVMVLGCMLPGVAARVSLSPKLGVYGDARGGSDLWGICIQAPTMPDTENQAPPRYAPETPLVGLDVAFRAENGFLLQLTVDAALTRLMFCGRCLAGYSFRPGEGSTHLSVAAGFECTALIYDSQHFLSVLGQGLLQPSSSSYSAGNWHRPRSLLGVLTCTAKEVGAIHEESRIKGVCQNYAVPVQLGVQHYFGAHWGIDATATVSFGIDTKLAKFRIPYTLRVGPVFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83638</accession>
    <name>O83638_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71300">
        <property type="entry name" value="D71300"/>
    </dbReference>
    <dbReference type="IntAct" id="O83638">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0630"/>
    <dbReference type="EnsemblBacteria" id="AAC65605">
        <property type="protein sequence ID" value="AAC65605"/>
        <property type="gene ID" value="TP_0630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75811">
        <property type="protein sequence ID" value="AGN75811"/>
        <property type="gene ID" value="TPANIC_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0630"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.624"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_12"/>
    <dbReference type="OMA" id="PGIIYKA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="303" mass="34397" checksum="40761792479F7023" modified="1998-11-01" version="1">MTAATEKSDITRSYLTLGKGVRPMSTLSDAEFAAFKTLIYEHSGITFSALNRSVLESRIRSRLRELALPSACAYYQQVLASSAELSALLDSVTTNLTRFFRNKAHFDSFSHYVIPELVKAKRSVGEHSITVWSAGCSTGEEPYTIAMLLKRYAPAAFSCQVIASDLSLKSLLVARQGYYPRARVSGVPDEYLRAYFRETQEGYQINADIRKMVRFDYHNLKHRSMHRNVDVLFCRNVLIYFDETAQKAVIERFWDAMSAHSFLFIGHSESLFGMNTKFSFLKTPWGCLCQKNDEGSAHECHAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83653</accession>
    <name>SYS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">TP_0647</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71299">
        <property type="entry name" value="F71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882092.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83653"/>
    <dbReference type="SMR" id="O83653"/>
    <dbReference type="IntAct" id="O83653">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0647"/>
    <dbReference type="EnsemblBacteria" id="AAC65620">
        <property type="protein sequence ID" value="AAC65620"/>
        <property type="gene ID" value="TP_0647"/>
    </dbReference>
    <dbReference type="GeneID" id="57879171"/>
    <dbReference type="KEGG" id="tpa:TP_0647"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_12"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122149" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="426" mass="48014" checksum="807C51405D29CEF9" modified="1998-11-01" version="1">MLDYRFIRENVDAVKENVKVRNVHADVDAIVHLYDQRVKLLAELQELQRARNENAQTMKSSLDALARSACVETGRALKDRIAHSERLLVQISDQLLSATQALPNMTHMCTPHGRSDSDNLEIKRCGVPPCFSFSPRDHVELARLLDIVDFEAGKKVSGIKFYYLKREGVLLEQALIMFGLQFLQERGFVPFLTPDIAREGMVCGLGFNPRGSGSNIYRIEGEHRCLVATAEITLGAYHAGEVLEERSLPRLYAGLSHCFRKEAGAAGQFSRGLYRVHQFTKLEMFAYCTPSDSECLHERLRSLEEEIFTALEIPFRVVEVCAGDLGAPAYRKWDLEAWMPGRQGGSWGEVTSASNCTDYQARRLNVRYKDAEGKKHYVHMLNGTALAISRVLIALLENGQDAEGRVRIPQALVPFCGFEYLYPRVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83664</accession>
    <name>FLIW_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fliW</name>
        <name type="ordered locus">TP_0658</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="7700" last="7706">
            <title>Novel conserved assembly factor of the bacterial flagellum.</title>
            <authorList>
                <person name="Titz B."/>
                <person name="Rajagopala S.V."/>
                <person name="Ester C."/>
                <person name="Haeuser R."/>
                <person name="Uetz P."/>
            </authorList>
            <dbReference type="PubMed" id="16936039"/>
            <dbReference type="DOI" id="10.1128/JB.00820-06"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH FLAGELLINS</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (PubMed:16936039).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 3">Interacts with translational regulator CsrA (By similarity). Interacts with flagellins FlaB1, FlaB2 and FlaB3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FliW family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71297">
        <property type="entry name" value="C71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882103.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83664"/>
    <dbReference type="SMR" id="O83664"/>
    <dbReference type="IntAct" id="O83664">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0658"/>
    <dbReference type="EnsemblBacteria" id="AAC65632">
        <property type="protein sequence ID" value="AAC65632"/>
        <property type="gene ID" value="TP_0658"/>
    </dbReference>
    <dbReference type="GeneID" id="57879181"/>
    <dbReference type="KEGG" id="tpa:TP_0658"/>
    <dbReference type="eggNOG" id="COG1699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112356_0_2_12"/>
    <dbReference type="OMA" id="DVAVFCI"/>
    <dbReference type="OrthoDB" id="1767625at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000273014" description="Flagellar assembly factor FliW">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P96503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16936039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="16936039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="150" mass="16925" checksum="8DEB1A015C5437AC" modified="1998-11-01" version="1">MEIQTKTLGTQTVEAHQIITLERGLYGFEKYHRFALFDAVQVPFIHMQSLDDPALSFIAIDPFLFRPDYELDIDDVLLQPLDISSPTDVLVFALVTIPPDGSAVTANLQGPLIVNKKNRKAMQVAMGGDRWRTKHDIVAEMAERRAQEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>O83665</accession>
    <name>O83665_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar hook-associated protein 3 (FlgL)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the core of the flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71297">
        <property type="entry name" value="D71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882104.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83665">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0659"/>
    <dbReference type="EnsemblBacteria" id="AAC65633">
        <property type="protein sequence ID" value="AAC65633"/>
        <property type="gene ID" value="TP_0659"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75837">
        <property type="protein sequence ID" value="AGN75837"/>
        <property type="gene ID" value="TPANIC_0659"/>
    </dbReference>
    <dbReference type="GeneID" id="57879182"/>
    <dbReference type="KEGG" id="tpa:TP_0659"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.651"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024437_7_0_12"/>
    <dbReference type="OMA" id="INRVSHP"/>
    <dbReference type="OrthoDB" id="1788350at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="416" mass="45569" checksum="E09D741AFAA51ECF" modified="1998-11-01" version="1">MGVKRISSHMQGTDSAFFLREQESRLRKVNNQLATQRRIQQLRDDPLAAGHSVRYKSSLARLDRFERNTKTLRDQYQIAEGFMTSALNVVQRLREMAVAGANGTYTPDDLKKMASEADELLQELVHNANAVSADGVRVFSGTKVFTEPFETVMGNVEGLGSEVITQVRYHGSLDPKNVEIDEHSYVGTHQAGSRVFWAERQILLSSVDARAYVLQQDARVTVDGVSIPLVAGDNVYAIISKINDSGAAVRAYLDPVTNGLNMETSDARQLWLQDEDEANVFASLGLITEGQRPPYNVSAGARVSGGSIFDMAIAVRNALLAGDQESLGGKILGSADGAVDNLSLRLAETGARYARAQATLARFNSHIPNVVAAESRESDIDLTQAITDLKMFEYTHQATLSTVGSLYKHTLLDYLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83680</accession>
    <name>Y674_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0674</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0674</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71294">
        <property type="entry name" value="B71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882119.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83680"/>
    <dbReference type="SMR" id="O83680"/>
    <dbReference type="STRING" id="243276.TPANIC_0674"/>
    <dbReference type="EnsemblBacteria" id="AAC65650">
        <property type="protein sequence ID" value="AAC65650"/>
        <property type="gene ID" value="TP_0674"/>
    </dbReference>
    <dbReference type="GeneID" id="57879198"/>
    <dbReference type="KEGG" id="tpa:TP_0674"/>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055978_3_0_12"/>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202299" description="Uncharacterized protein TP_0674">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="116"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00321"/>
        </source>
    </evidence>
    <sequence length="202" mass="22441" checksum="F28A9BE07F8685D8" modified="1998-11-01" version="1">MRPLMAGKRRKDILPLEEALRAQSAFARTLRTWEGARRAAVRSATVRARRRGALPSSQAAAAPRVSLMEVALARYGLFDKDAAGACAEYARQRRTFSIHSRRGRRKLRTAVPEARLDLHGMTCSEARSALDSFFAQARERLLQKVEIVHGKGHHSKGGSVLAPSVKRYVQAHPHAGELFHPAERRGGKGTTWVLLKRSVPLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83685</accession>
    <name>Y679_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0679</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0679</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71294">
        <property type="entry name" value="G71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882124.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83685"/>
    <dbReference type="IntAct" id="O83685">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0679"/>
    <dbReference type="EnsemblBacteria" id="AAC65655">
        <property type="protein sequence ID" value="AAC65655"/>
        <property type="gene ID" value="TP_0679"/>
    </dbReference>
    <dbReference type="GeneID" id="57879204"/>
    <dbReference type="KEGG" id="tpa:TP_0679"/>
    <dbReference type="HOGENOM" id="CLU_2235393_0_0_12"/>
    <dbReference type="OMA" id="FLMYISI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202304" description="Uncharacterized protein TP_0679">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="105" mass="11586" checksum="068BADCD2502523C" modified="1998-11-01" version="1">MNEFLSLLSRAQTILLMLRLAVTAVAVFLAIVAWTKTRTQETVCFIAGVLCMYLAQLFAFLRAAGFSITRYTPVPGVSLVGFTLELLPLACFIASLIFTIKRHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83695</accession>
    <name>O83695_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71293">
        <property type="entry name" value="F71293"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65666">
        <property type="protein sequence ID" value="AAC65666"/>
        <property type="gene ID" value="TP_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0697"/>
    <dbReference type="HOGENOM" id="CLU_1304419_0_0_12"/>
    <dbReference type="OMA" id="FCTDANA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004160546" evidence="1">
        <location>
            <begin position="29"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="202" mass="21440" checksum="08867D2B93E13155" modified="1998-11-01" version="1">MCRLRRSVAGGGALFLAVLWGLCTDANAAQVFVSPRVGQVGVFVWGKGANGEGGTQGTKRTDILAFTPTLGLSVGVSAENGFTFVTQLDAGLSTLLFRAQFLLGWVLRMGERAFFLPSTGVDIMSTKDKIVGVPVNLDFHFFFTGVVGLSVGVASGVGIPITANLEQCKNGAGSTDLKWEQFLQKYCLECPLTVQIGPVFRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83699</accession>
    <name>RPOZ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase subunit omega</fullName>
            <shortName>RNAP omega subunit</shortName>
            <ecNumber>2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rpoZ</name>
        <name type="ordered locus">TP_0701</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71289">
        <property type="entry name" value="A71289"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882146.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83699"/>
    <dbReference type="SMR" id="O83699"/>
    <dbReference type="IntAct" id="O83699">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0701"/>
    <dbReference type="EnsemblBacteria" id="AAC65670">
        <property type="protein sequence ID" value="AAC65670"/>
        <property type="gene ID" value="TP_0701"/>
    </dbReference>
    <dbReference type="GeneID" id="57879226"/>
    <dbReference type="KEGG" id="tpa:TP_0701"/>
    <dbReference type="eggNOG" id="ENOG502ZVPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187773_0_0_12"/>
    <dbReference type="OMA" id="SYQLSML"/>
    <dbReference type="OrthoDB" id="2018659at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000129006" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="67" mass="7349" checksum="36D34AA347B48E10" modified="1998-11-01" version="1">MIFPMQQLIEFQGNIYEITCAATRRAFQLAAVCDPVLDELGGKVVSAAAQQVFSGTVDYRIEPQELG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83716</accession>
    <name>DEOD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="2">PNP</shortName>
            <ecNumber evidence="2">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">deoD</name>
        <name type="ordered locus">TP_0734</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71288">
        <property type="entry name" value="C71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882179.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83716"/>
    <dbReference type="SMR" id="O83716"/>
    <dbReference type="STRING" id="243276.TPANIC_0734"/>
    <dbReference type="EnsemblBacteria" id="AAC65702">
        <property type="protein sequence ID" value="AAC65702"/>
        <property type="gene ID" value="TP_0734"/>
    </dbReference>
    <dbReference type="GeneID" id="57879258"/>
    <dbReference type="KEGG" id="tpa:TP_0734"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_12"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000063168" description="Purine nucleoside phosphorylase DeoD-type">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P50389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="233" mass="25318" checksum="D1A94487B7434A23" modified="1998-11-01" version="1">MSIHLGAKGEDIAPRVLLPGDPLRARFVAERFFHNAYCYNEVRGMLGFTGTYKGVRVSVQGTGMGLPSHSIYVTELFQDYGVQKAIRVGTAGGLQEEVALKSVVCALGAATDSAINARRFSGMHFAPTASWSLLRTAVSVADEMGTGVQVGNVISSDVFYDESGSWRLWARYGVLAVEMETAELYTLAAKFRREALSILTISDHLVTGAVTSAQERERSFTQMIEIALEAIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83719</accession>
    <name>O83719_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter, periplasmic binding protein (MsmE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71288">
        <property type="entry name" value="F71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882182.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0737"/>
    <dbReference type="EnsemblBacteria" id="AAC65705">
        <property type="protein sequence ID" value="AAC65705"/>
        <property type="gene ID" value="TP_0737"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75911">
        <property type="protein sequence ID" value="AGN75911"/>
        <property type="gene ID" value="TPANIC_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="57879261"/>
    <dbReference type="KEGG" id="tpa:TP_0737"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.726"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_12"/>
    <dbReference type="OMA" id="QNKIAFT"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="436" mass="48292" checksum="F4AE907409DE1603" modified="1998-11-01" version="1">MRNTGSATYARIGGVFLSFFVLLPVFCHGSKEKGKEEEPVRLSVLIREKHYSSGLQNVFTKLELEEGIAVTVETIQDDQYPTVLHARLADGTAPDVVEVSLPSLHALDPYLYFVDLSKEAWIPDLLIPPTDPYGKTFALPLNCAVSINALFYNKDLFDRYGISEPKSWNELLESCALIVKSGISIVPLALSTTESFPHTLLADAITKVLGEQGARDLVKRATDDSIDWTHERALYPVLGAYLELFKRGYVNKHHRTARVREIIHDFTRDRIAMYFGSHLVADAIIKERPGINLGACVLPITENAQDVLTGSLEVQGLAVHKKSARVATACRALSVLASAAYQNSFFEEHKGLPAFRNTTSAVIPACLSALFKSHIEKGKVIQAIDAYAQAQNTPHRASVFPDFAAYVTDPAPTAHTMLHRAQTEARRRREPVQKKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83723</accession>
    <name>NADD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber>2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName>NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nadD</name>
        <name type="ordered locus">TP_0741</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71286">
        <property type="entry name" value="B71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882186.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83723"/>
    <dbReference type="SMR" id="O83723"/>
    <dbReference type="IntAct" id="O83723">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0741"/>
    <dbReference type="EnsemblBacteria" id="AAC65710">
        <property type="protein sequence ID" value="AAC65710"/>
        <property type="gene ID" value="TP_0741"/>
    </dbReference>
    <dbReference type="GeneID" id="57879265"/>
    <dbReference type="KEGG" id="tpa:TP_0741"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_1_12"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000181462" description="Probable nicotinate-nucleotide adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="204" mass="22650" checksum="498E35DBB54C10E6" modified="1998-11-01" version="1">MKLALFGGSYDPVHLGHLLLADAVHRHAGYDRVLFVPTFVSPFKEKEGSASAHDRVRMLHLAIGTTPYFSVEECEIRRGGISYTAETVQHVREKYGAQLEGKLALVLGEDAARSVPHWHAFDSWSTHVDFVVGARPVTSGDGGNVERATRTLQSFPFPWVSAENVALPISSTYIRTAIQRGRSWGYLVPSPVREYIIARGLYRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83729</accession>
    <name>Y747_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0747</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0747</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71286">
        <property type="entry name" value="H71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882192.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83729"/>
    <dbReference type="IntAct" id="O83729">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0747"/>
    <dbReference type="EnsemblBacteria" id="AAC65718">
        <property type="protein sequence ID" value="AAC65718"/>
        <property type="gene ID" value="TP_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="57879271"/>
    <dbReference type="KEGG" id="tpa:TP_0747"/>
    <dbReference type="eggNOG" id="ENOG5033THS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813628_0_0_12"/>
    <dbReference type="OMA" id="EVYIYYE"/>
    <dbReference type="OrthoDB" id="819018at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202313" description="Uncharacterized protein TP_0747">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="344" mass="37779" checksum="586188F5090790EF" modified="1998-11-01" version="1">MVSASSFYVPAAVKKNFNALVRHVKGVLSVLDECDPKNNVADQVNLLLCAKEMQSEQVAALLSVLLIDTWGYRLFSYNLRKVSVEGLGFAQETARWKGVDIVLGYHHPDLGFLAINPKNPSNASLVEGFRKNELLLVYVGKQDRGPLDERIADEVAKGLIALIENRKFVVPKEILSGVFAFVSTKKSEGSGKRVRSAKKSGADAARASEGATCDRASSESVSPTARPPAQASAGPIRMSQLISVPVSNELFHNGNVEAWKRIIRSYNARYPSSEVIVFYDGERIVDINTLFKWGKVKHGSVIQFAVSGEEIKDLSKLSKYFKEGASSRFEVFLHGSPDTVLNLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83730</accession>
    <name>Y749_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0749</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0749</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71287">
        <property type="entry name" value="B71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882194.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83730"/>
    <dbReference type="SMR" id="O83730"/>
    <dbReference type="STRING" id="243276.TPANIC_0749"/>
    <dbReference type="EnsemblBacteria" id="AAC65719">
        <property type="protein sequence ID" value="AAC65719"/>
        <property type="gene ID" value="TP_0749"/>
    </dbReference>
    <dbReference type="GeneID" id="57879589"/>
    <dbReference type="KEGG" id="tpa:TP_0749"/>
    <dbReference type="HOGENOM" id="CLU_2703759_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202314" description="Uncharacterized protein TP_0749">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <sequence length="73" mass="8606" checksum="844EE7CC035B6AC9" modified="1998-11-01" version="1">MQDKALFSGALDTPFMQVITWARLYHKNQKRYEKIKKSFTFHETCLQSTKGIVAERILKPCVRRKVNGKFRST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83737</accession>
    <name>FMT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">TP_0756</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71284">
        <property type="entry name" value="G71284"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882201.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83737"/>
    <dbReference type="SMR" id="O83737"/>
    <dbReference type="IntAct" id="O83737">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0756"/>
    <dbReference type="EnsemblBacteria" id="AAC65723">
        <property type="protein sequence ID" value="AAC65723"/>
        <property type="gene ID" value="TP_0756"/>
    </dbReference>
    <dbReference type="GeneID" id="57879279"/>
    <dbReference type="KEGG" id="tpa:TP_0756"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_2_0_12"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083077" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="319" mass="34261" checksum="92DAEEE1ACE33D3A" modified="1998-11-01" version="1">MVRVFFAGTPECAVPSLRRVACAHRVVGVLTNPPAAVGRSGKLVHSAVAREFFRLKASGVLPESASLFVPGRLDRAFYDAVEALRPDVLVCFAYGKIFGPRFLALFPRGAINVHPSLLPRWRGSTPVPAAILAGDCETGVTLQYIGEEMDAGDILAQSRVQLDGTETTGALLSRLSLVAADLVDDVLVGVERHTLAPAAQDHSQATFCGKLCREMGLADWSNPAVVLERKIRAFTPWPGLFTYKDGERIAILQARSCESSFVPLAPVGTVLAADKNGVFVQTGDGVLSLLQLQRSGKKPLFWRDFLNGSPLLLTGRLGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83743</accession>
    <name>Y762_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0762</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0762</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71285">
        <property type="entry name" value="E71285"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882207.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83743"/>
    <dbReference type="SMR" id="O83743"/>
    <dbReference type="STRING" id="243276.TPANIC_0762"/>
    <dbReference type="EnsemblBacteria" id="AAC65733">
        <property type="protein sequence ID" value="AAC65733"/>
        <property type="gene ID" value="TP_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0762"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756350_0_0_12"/>
    <dbReference type="OMA" id="TEKGGEW"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202317" description="Uncharacterized protein TP_0762">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="393" mass="43864" checksum="8C2E7D17B5D42CC5" modified="1998-11-01" version="1">MCSARVTPDVVLLFDPQYWNYLHVARAVAPHALLITDISVFPAVFRLPWEYIVLAGSACPFATSLAHHDASCSPSHALPLPFVAPDLLASGGSVATSAWECARYLGATTIVYIGLDLAFPGARTHFRGALFEERAHLQSGRVAPAETTSFCALHSLPLYPVPAASDPHPGKNSPASPTGENKEQTVLTDARFSLYAVWLEAHLARYTHIKTYALEPAGRRVAGITPLRFSQLVTLLNRSAAVPHCRTMYSRRRRLYSRYRNSSVQVNCTDAVRWRRTMKSTPVHCLGHFTKKKKSAEGARNLWRALRRADTRCASPHNLEHALERTRSFLNAMPLTPTTYENKTHALYTALCTLLPTEPTYRARAHAHLFELLTRTLKFCAAYTEEEGEWREA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83748</accession>
    <name>EFG1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor G 1</fullName>
            <shortName>EF-G 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fusA</name>
        <name type="synonym">fusA-2</name>
        <name type="ordered locus">TP_0767</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71283">
        <property type="entry name" value="D71283"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882212.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83748"/>
    <dbReference type="SMR" id="O83748"/>
    <dbReference type="STRING" id="243276.TPANIC_0767"/>
    <dbReference type="PRIDE" id="O83748"/>
    <dbReference type="EnsemblBacteria" id="AAC65735">
        <property type="protein sequence ID" value="AAC65735"/>
        <property type="gene ID" value="TP_0767"/>
    </dbReference>
    <dbReference type="GeneID" id="57879289"/>
    <dbReference type="KEGG" id="tpa:TP_0767"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_0_12"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045044">
        <property type="entry name" value="EFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="PTHR43636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091254" description="Elongation factor G 1">
        <location>
            <begin position="1"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="6"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="695" mass="76831" checksum="46529989BFE97E4E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83752</accession>
    <name>O83752_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic serine protease DO (HtrA-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71284">
        <property type="entry name" value="B71284"/>
    </dbReference>
    <dbReference type="IntAct" id="O83752">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0773"/>
    <dbReference type="EnsemblBacteria" id="AAC65740">
        <property type="protein sequence ID" value="AAC65740"/>
        <property type="gene ID" value="TP_0773"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75946">
        <property type="protein sequence ID" value="AGN75946"/>
        <property type="gene ID" value="TPANIC_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0773"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.760"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_12"/>
    <dbReference type="OMA" id="DTRHFDY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="282"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="398" mass="42186" checksum="8715EA05F454258D" modified="1998-11-01" version="1">MRNKVRVLAVVAALAAACAVGFFLGRWFDFSARSSVLEAADSLSVSSSEAASFSTVVAEGDPYTVDERQNIAVYRSANEAVVNITTEMVGVNWFLEPVPLEGGSGSGAIIDARGYVLTNTHVIEGASKIYLSLHDGSQYKATVVGVDRENDLAVLKFVSPPGARLTVIRFGSSRNLDVGQKVLAIGNPFGLARTLTVGVVSALARPIQNKGSIIRNMIQTDAAINPGNSGGPLLDTQGRMIGINTVIYSTSGSSSGVGFAVPVDTAKRIVSELIRYGRVRRGKIDAELVQVNASIAHYAQLTVGKGLLVSQVKRGSPAAQAGLRGGTTAVRYGLGRRAAVIYLGGDVITAIDNQPVANLSDYYSVLEDKKPDDEVRVTVLRGRRQHVVAVRLTERSDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83760</accession>
    <name>Y781_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0781</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0781</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71282">
        <property type="entry name" value="F71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882226.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83760"/>
    <dbReference type="STRING" id="243276.TPANIC_0781"/>
    <dbReference type="EnsemblBacteria" id="AAC65751">
        <property type="protein sequence ID" value="AAC65751"/>
        <property type="gene ID" value="TP_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0781"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1712465_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202322" description="Uncharacterized protein TP_0781">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <sequence length="153" mass="16678" checksum="2D68DA244416CF5B" modified="1998-11-01" version="1">MSDTIKPTIQDVVLAGKTGVLALSGTAAPRDADGYVYTRKRTRVHRRVTQGTYRLYAAVADVLEHGTQTFTPFQVHVVVNGSEVSAVSFELIVAKDSQACLSGSLLNERLLYEMKGRVFLGSVVLTRGTAELAISARDISGNERTEVFFLQVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83777</accession>
    <name>Y799_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0799</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0799</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71281">
        <property type="entry name" value="F71281"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83777"/>
    <dbReference type="IntAct" id="O83777">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0799"/>
    <dbReference type="EnsemblBacteria" id="AAC65768">
        <property type="protein sequence ID" value="AAC65768"/>
        <property type="gene ID" value="TP_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0799"/>
    <dbReference type="HOGENOM" id="CLU_3123857_0_0_12"/>
    <dbReference type="OMA" id="KEHPVRY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202329" description="Uncharacterized protein TP_0799">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="50" mass="5796" checksum="6E788CB5CC9A818F" modified="1998-11-01" version="1">MKTGFWQQVLPKRAGRRKEHPVQYMPHKKEENATGLMNPSLHTSHSAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83783</accession>
    <name>O83783_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exoribonuclease II (Rnb)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71279">
        <property type="entry name" value="G71279"/>
    </dbReference>
    <dbReference type="IntAct" id="O83783">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0805"/>
    <dbReference type="EnsemblBacteria" id="AAC65772">
        <property type="protein sequence ID" value="AAC65772"/>
        <property type="gene ID" value="TP_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0805"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.851"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015903_2_0_12"/>
    <dbReference type="OMA" id="YWCLRWL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="274"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="759" mass="84449" checksum="C41552FC4FD045B9" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83801</accession>
    <name>O83801_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71276">
        <property type="entry name" value="G71276"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882273.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83801">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0829"/>
    <dbReference type="EnsemblBacteria" id="AAC65795">
        <property type="protein sequence ID" value="AAC65795"/>
        <property type="gene ID" value="TP_0829"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75999">
        <property type="protein sequence ID" value="AGN75999"/>
        <property type="gene ID" value="TPANIC_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0829"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.816"/>
    <dbReference type="eggNOG" id="COG1655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083032_0_0_12"/>
    <dbReference type="OMA" id="KNPRTCP"/>
    <dbReference type="OrthoDB" id="606787at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018708">
        <property type="entry name" value="DUF2225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09986">
        <property type="entry name" value="DUF2225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="294" mass="33779" checksum="BF9CE4D09B6B9D58" modified="1998-11-01" version="1">MTRSSTKKTDKKESTVSFYSKERIECPVCTTVFQREEMHSGGGRTIAGDLTDELRRTYETSAKYGEVFPPIYHVVVCPTCLYATFLQDFRNIERGIVTKLSSTTSQRRTSVERLIPQVDFSALRTLSSGAAAYYLAILCYDFFDKKYSPTIKQGICALRAAWLFSDLEKKDPNEHYDYIRNLLYQKALFFYRKAIECESTGEEIIAGLKSFGPDTDKNYGYDGVLYLSYLLEYKYGTKRDRAVRRERMQRNKQGLAKIFGLGKSSKEKPGPLLELARQLYENLLAELHEDSETT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83807</accession>
    <name>O83807_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71274">
        <property type="entry name" value="H71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882279.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0835"/>
    <dbReference type="EnsemblBacteria" id="AAC65803">
        <property type="protein sequence ID" value="AAC65803"/>
        <property type="gene ID" value="TP_0835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76005">
        <property type="protein sequence ID" value="AGN76005"/>
        <property type="gene ID" value="TPANIC_0835"/>
    </dbReference>
    <dbReference type="GeneID" id="57879352"/>
    <dbReference type="KEGG" id="tpa:TP_0835"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.822"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015673_0_0_12"/>
    <dbReference type="OMA" id="ADWLDWR"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="382"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="544"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="781"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="815"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="934" mass="100688" checksum="098E5F9F0165A2BB" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-12-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83817</accession>
    <name>Y845_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0178 protein TP_0845</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0845</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0178 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65813" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65813.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71273">
        <property type="entry name" value="E71273"/>
    </dbReference>
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    <dbReference type="IntAct" id="O83817">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0845"/>
    <dbReference type="EnsemblBacteria" id="AAC65813">
        <property type="protein sequence ID" value="AAC65813"/>
        <property type="gene ID" value="TP_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0845"/>
    <dbReference type="eggNOG" id="COG1671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106619_2_0_12"/>
    <dbReference type="OMA" id="DADSCPK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176018" description="UPF0178 protein TP_0845">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="177" mass="19772" checksum="7CB90D4D32EB2DEE" modified="2001-12-05" version="2">MTLWVDADSCPARVRVLVARAAARLGCVARFVANRPIPLVQSPHCIMVETQPVDQAADRHIIAYARAGDLVVTRDIVLAKAIVDARISVINDRGDVYTEENIRERLSVRNFMYDLRGQGLAPETTSPFGRRDAARFADSLDRETAKLLRLARRREAKTGEEQCDWPSAQGKSQTGRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83827</accession>
    <name>Y855_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0855</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0855</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71274">
        <property type="entry name" value="G71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882299.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83827"/>
    <dbReference type="STRING" id="243276.TPANIC_0855"/>
    <dbReference type="PRIDE" id="O83827"/>
    <dbReference type="EnsemblBacteria" id="AAC65823">
        <property type="protein sequence ID" value="AAC65823"/>
        <property type="gene ID" value="TP_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0855"/>
    <dbReference type="eggNOG" id="ENOG5033Q9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011448_0_0_12"/>
    <dbReference type="OrthoDB" id="654985at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014265" description="Uncharacterized protein TP_0855">
        <location>
            <begin position="27"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1127" mass="124701" checksum="C10D4E622C484D39" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83834</accession>
    <name>O83834_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71272">
        <property type="entry name" value="F71272"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882306.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0862"/>
    <dbReference type="EnsemblBacteria" id="AAC65825">
        <property type="protein sequence ID" value="AAC65825"/>
        <property type="gene ID" value="TP_0862"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76031">
        <property type="protein sequence ID" value="AGN76031"/>
        <property type="gene ID" value="TPANIC_0862"/>
    </dbReference>
    <dbReference type="GeneID" id="57879377"/>
    <dbReference type="KEGG" id="tpa:TP_0862"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.847"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_0_1_12"/>
    <dbReference type="OMA" id="KYMSGHI"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="173"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="264" mass="28416" checksum="2E936EF48A223A2E" modified="1998-11-01" version="1">MILKKEAAGVCSFALLLLAGMSIFSCRKGAEGVSSAGEAADKKALTADQLDPRKVQEQERQKTPLSKKSVGYAFGVLMGVTLQDSKLDVDLGQVWKGLKKTVSADKDKQALADAQDVLQRAFEAYRQKEVEKNSQEAKAFLEENAKKPGVQVTSSGLQYEVVKAADGPKPQGGQRVRTQYKGTLLDGTVFDASRDKPAEFPVDGMVPGVSEGLKLMPVGSTYRFYVPSSLGYGERGIEGVIPPGALLVFEIELQEILPDSASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83836</accession>
    <name>O83836_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71272">
        <property type="entry name" value="H71272"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882308.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83836">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0864"/>
    <dbReference type="EnsemblBacteria" id="AAC65827">
        <property type="protein sequence ID" value="AAC65827"/>
        <property type="gene ID" value="TP_0864"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76033">
        <property type="protein sequence ID" value="AGN76033"/>
        <property type="gene ID" value="TPANIC_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0864"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.849"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498683_0_0_12"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="546" mass="58515" checksum="D106CE90EBC06BD4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83838</accession>
    <name>Y867_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0867</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0867</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71270">
        <property type="entry name" value="A71270"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882310.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83838"/>
    <dbReference type="IntAct" id="O83838">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0867"/>
    <dbReference type="EnsemblBacteria" id="AAC65844">
        <property type="protein sequence ID" value="AAC65844"/>
        <property type="gene ID" value="TP_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0867"/>
    <dbReference type="HOGENOM" id="CLU_3031120_0_0_12"/>
    <dbReference type="OMA" id="QYTRVSH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202341" description="Uncharacterized protein TP_0867">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <sequence length="61" mass="7243" checksum="58F6AF412FF6F710" modified="1998-11-01" version="1">MRWLCRLIGYRYGYAVCGGYRRQGGRCSAQLHAQYTRVSHCVLRIAWEVNGADYELFRLWI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83848</accession>
    <name>Y878_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0878</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0878</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71271">
        <property type="entry name" value="D71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882321.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83848"/>
    <dbReference type="STRING" id="243276.TPANIC_0878"/>
    <dbReference type="EnsemblBacteria" id="AAC65848">
        <property type="protein sequence ID" value="AAC65848"/>
        <property type="gene ID" value="TP_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0878"/>
    <dbReference type="eggNOG" id="ENOG5031CDY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871360_0_0_12"/>
    <dbReference type="OMA" id="CIDIFPA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202345" description="Uncharacterized protein TP_0878">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="316" mass="37313" checksum="C66A98B541CBC88E" modified="1998-11-01" version="1">MRSVDSRSSVTRWVCLTSVILFCFCIAVMRYGGVKKRRYFYGFCLHPRERADITEVILRFPREERNASRELRWVKKDRQWFIQLAHAIHPAKQEVLERLFQYLFTKRRFEFITNNTRFFSDYALGKQPAVQMKFTKKNGAAIGDIYFGALNGTGLGRYIRIGDNAAVFLTEDDFTPFFRDEKRFWCDTRQFHELFTQSQIQMMEVSGKYIVRSRTSVVFKEVEQFFARFSYVDVGPTPTQWKESIVIHRGDGKIIRFRLQPAAHQEWTLWDAQSVHAYTLSAYTARYLFALISRMQTETGMSSLQQFDTEENLISD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O83873</accession>
    <name>MURD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber>6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">murD</name>
        <name type="ordered locus">TP_0903</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71267">
        <property type="entry name" value="D71267"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882346.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83873"/>
    <dbReference type="SMR" id="O83873"/>
    <dbReference type="IntAct" id="O83873">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0903"/>
    <dbReference type="EnsemblBacteria" id="AAC65856">
        <property type="protein sequence ID" value="AAC65856"/>
        <property type="gene ID" value="TP_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0903"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_1_12"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000109116" description="UDP-N-acetylmuramoylalanine--D-glutamate ligase">
        <location>
            <begin position="1"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="532" mass="57848" checksum="9FD705C2AE478ADD" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83888</accession>
    <name>O83888_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71265">
        <property type="entry name" value="C71265"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882361.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83888">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0918"/>
    <dbReference type="EnsemblBacteria" id="AAC65874">
        <property type="protein sequence ID" value="AAC65874"/>
        <property type="gene ID" value="TP_0918"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76085">
        <property type="protein sequence ID" value="AGN76085"/>
        <property type="gene ID" value="TPANIC_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0918"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.901"/>
    <dbReference type="eggNOG" id="COG0170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_4_0_12"/>
    <dbReference type="OMA" id="VAFIVCY"/>
    <dbReference type="OrthoDB" id="1421771at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="257" mass="26922" checksum="69A78F5782E7AEF3" modified="1998-11-01" version="1">MDAEDQNNTLQTAAPCRRGEHPARIGAVQAGANPAARTRRAAHVESMHARLASECLRKGIHLSSALSIVLAAWSKPLTLGAIGTLGVGYYVAERWRLRGKTLPLVSLLTRAAARDRDKHERSLVRGPLTLAIGVSSAILLFPPPIAAAAICALAFGDGCASLAGTVYTFLRFKNSADSPGRRRGRTTTLFSVQGKTPVGSAVCCIATALSVHALGASGARSWGLGVCAALIELLPCKDYDNITVPLGTGCIALLMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83904</accession>
    <name>O83904_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71262">
        <property type="entry name" value="B71262"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882377.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0934"/>
    <dbReference type="EnsemblBacteria" id="AAC65891">
        <property type="protein sequence ID" value="AAC65891"/>
        <property type="gene ID" value="TP_0934"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76099">
        <property type="protein sequence ID" value="AGN76099"/>
        <property type="gene ID" value="TPANIC_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0934"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.916"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056006_0_0_12"/>
    <dbReference type="OMA" id="EAYLIFR"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="407" mass="44358" checksum="47B689F851110B9B" modified="1998-11-01" version="1">MKIWLKFFVGSCIGALVAYTIPETLSAPLMQTISELVVSAGSYMLYPVIFFGFSVSIFEMRRERLLLRTTLISIGACVATAFSLSLVGLFSVLVYRPARIPIFATGTPQNPGFQIRTFFLQLFPASSFEVFTNGDYLLPLCVFASFVGAGCAVDHVAAKPVLALFESLTRVAHTVMVFFVDMLSIGFIALSAHWLFRFRPLLSTGVFTDLVILLTLTAIFICSVLYPALIKIMCPEVNPYRVLYAALAPMSTAFFSQNVHATLPVLLYHAEESIGVQRTTATVLLSIFSIFGRAGSACAITMSFALILKSYSHLGIGFFDALWIITAASFLSIFLGRFPTGGVLIALASICAWYGRGFGSGYLVIRPAAFFVGSIATTLDTLNALICTAISAERIGTVRHRAVRFFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83911</accession>
    <name>Y941_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0941</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0941</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71263">
        <property type="entry name" value="A71263"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882384.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83911"/>
    <dbReference type="IntAct" id="O83911">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0941"/>
    <dbReference type="EnsemblBacteria" id="AAC65900">
        <property type="protein sequence ID" value="AAC65900"/>
        <property type="gene ID" value="TP_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="57879451"/>
    <dbReference type="KEGG" id="tpa:TP_0941"/>
    <dbReference type="eggNOG" id="ENOG5031CDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1539354_0_0_12"/>
    <dbReference type="OMA" id="WFNIFEI"/>
    <dbReference type="OrthoDB" id="1471418at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202359" description="Uncharacterized protein TP_0941">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <sequence length="172" mass="19647" checksum="DA4DEB8B1D209887" modified="1998-11-01" version="1">MEPAVILRPLLEKGELKQSVERAQRARYVLYEVQDQGLNFVTASVLADVSAVEKMGLIRRTGKLFSDQEYCDLLNQKVFTVHPDMRGSLKEQGVAFASVEARAYGHWYGIFEVAFPWLPLSVFEDFVLYLRDTKSLSLDEQTAAAVKESFLACRRYSERELDVLFERVLSGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83912</accession>
    <name>Y942_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0942</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0942</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71263">
        <property type="entry name" value="B71263"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882385.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83912"/>
    <dbReference type="SMR" id="O83912"/>
    <dbReference type="IntAct" id="O83912">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0942"/>
    <dbReference type="EnsemblBacteria" id="AAC65901">
        <property type="protein sequence ID" value="AAC65901"/>
        <property type="gene ID" value="TP_0942"/>
    </dbReference>
    <dbReference type="GeneID" id="57879452"/>
    <dbReference type="KEGG" id="tpa:TP_0942"/>
    <dbReference type="eggNOG" id="ENOG50343Q9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677080_0_0_12"/>
    <dbReference type="OMA" id="FAHNEEN"/>
    <dbReference type="OrthoDB" id="1458039at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202360" description="Uncharacterized protein TP_0942">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="154" mass="17418" checksum="EE465BB1896BF82A" modified="1998-11-01" version="1">MDGARVSDEEVARRVATLKRLKALLQEQREKFAQYLVVLQQQQVAIEAQDAETVLRHVELEEALLGDVQRVQKALAPMEQLCLQQASGVQELAQLRCDLSRVQEQVYAQNEKNRALLRAQVSDLRQQLDEFRAARGLVSYEDGEDSGTVIDLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83913</accession>
    <name>O83913_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71263">
        <property type="entry name" value="C71263"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882386.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83913">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0943"/>
    <dbReference type="EnsemblBacteria" id="AAC65896">
        <property type="protein sequence ID" value="AAC65896"/>
        <property type="gene ID" value="TP_0943"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76107">
        <property type="protein sequence ID" value="AGN76107"/>
        <property type="gene ID" value="TPANIC_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0943"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.926"/>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080373_3_0_12"/>
    <dbReference type="OMA" id="EFRDTWK"/>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16626" checksum="6B0EC94DDB8FD85F" modified="1998-11-01" version="1">MAYEDPALSAYRQVDVKTASQGELILLLYDEGIKQLGCAIELMDVQKIPASDIERVHRHILKAQEIITELSVSLDMEAGEKIAQNLLSIYAYFNQQLFHANIQKRADELVTVRDMMRQLREAWFQIVRSPASSVTSASPASYNVNLAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83934</accession>
    <name>Y968_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0968</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0968</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TP096X family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71260">
        <property type="entry name" value="C71260"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882412.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83934"/>
    <dbReference type="IntAct" id="O83934">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0968"/>
    <dbReference type="EnsemblBacteria" id="AAC65926">
        <property type="protein sequence ID" value="AAC65926"/>
        <property type="gene ID" value="TP_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0968"/>
    <dbReference type="HOGENOM" id="CLU_504256_0_0_12"/>
    <dbReference type="OMA" id="EFHMGDA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014268" description="Uncharacterized protein TP_0968">
        <location>
            <begin position="21"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="540" mass="60063" checksum="40840E5CCC008FE4" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83960</accession>
    <name>O83960_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71255">
        <property type="entry name" value="D71255"/>
    </dbReference>
    <dbReference type="IntAct" id="O83960">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0995"/>
    <dbReference type="EnsemblBacteria" id="AAC26583">
        <property type="protein sequence ID" value="AAC26583"/>
        <property type="gene ID" value="TP_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0995"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640823_0_0_12"/>
    <dbReference type="OMA" id="IFMGEMS"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="294"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC26583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="428" mass="48544" checksum="19CE8AFFAEE44327" modified="1998-11-01" version="1">MSMSKIPLISTVTSTISAINGACTGERVDIHIQTLSRLNEIASVFRFEMPEIKIIDFGDPNVDSEACLKIIKDDPWLLFGGVIAITNSMEEKIKIVNRKDPNFLSVSTRQEFEAHASQVVRIVDRNRHFLSSRSLVHQAHGHEQGNFICDTDSFEITFYASLISSYLYNTNRINELERTSFEGAMMELLLNALEHGNCGISYDEKTEWLEQRKDIFDLIALRKQDPRISAKKIYISYDITLQRTRITIRDEGTGFDWKSRMASACKPGLHGMGIKMTEIFVKRLSYNDVGNEVTFEIDNQENVANLVPSILKNQQVLTFRDAQVVCYQNEESSSLFYISSGKFAVYVDNKFMSMLTPSDIFIGEMSFLLNNRRSATIVSVGEGTLVKISKMKFISLIEDHPHYGIYLARLLAGRLAHQSRESASLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83967</accession>
    <name>O83967_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_1002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71254">
        <property type="entry name" value="D71254"/>
    </dbReference>
    <dbReference type="IntAct" id="O83967">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1002"/>
    <dbReference type="EnsemblBacteria" id="AAC65951">
        <property type="protein sequence ID" value="AAC65951"/>
        <property type="gene ID" value="TP_1002"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76166">
        <property type="protein sequence ID" value="AGN76166"/>
        <property type="gene ID" value="TPANIC_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1002"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.987"/>
    <dbReference type="eggNOG" id="COG5497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219100_0_0_12"/>
    <dbReference type="OMA" id="YFMFGEY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018725">
        <property type="entry name" value="DUF2259_secreted"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10016">
        <property type="entry name" value="DUF2259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503429" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24785" checksum="06B875DB1B911330" modified="1998-11-01" version="1">MCYLAAVFLTLCTKSAMAGDIATFVNLGFSAHGKTFAFGQHGVTDGLYQAYADIYVVDVESNRFVQGGVVRTTPTRETKGKRSMDVFLALQNRAQSLLQRADISALRLGRTLYVQAEDRMGEETLLFRDFKTNVEYVVVMHVERTTELGVSFYLTVEMTRPNGSKVSRVVGQRGYVRPGVKNYALKKVLINEQQDALIFVVEKHGYAPDGASVRYMVEACRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-07-11" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83971</accession>
    <name>THYX_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name type="ordered locus">TP_1007</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71255">
        <property type="entry name" value="A71255"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83971"/>
    <dbReference type="SMR" id="O83971"/>
    <dbReference type="IntAct" id="O83971">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1007"/>
    <dbReference type="EnsemblBacteria" id="AAC65955">
        <property type="protein sequence ID" value="AAC65955"/>
        <property type="gene ID" value="TP_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1007"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067790_0_0_12"/>
    <dbReference type="OMA" id="EWARLMP"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175583" description="Flavin-dependent thymidylate synthase">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ThyX" evidence="2">
        <location>
            <begin position="50"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="ThyX motif" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00661"/>
        </source>
    </evidence>
    <sequence length="305" mass="34186" checksum="6562EA1814B5D9FB" modified="1998-11-01" version="1">MTLRTLQAGVAVSIALDRVCFFCYNGAVAHCVVEAAEDILDRRFSVLDKGFVRLIDYLGGDARIVQAARVSYGAGTRTARDDAALIDFLLRNKHTSPFEQVVLTFHVRAPIFVARQWMRHRTARISEVSSRYSLLSHDCYVPQETSVAVQSTRNKQGRASEGISPEQQQEVRAAFEAQQKAACAAYDALIQKNIARELARINVPLSLYTEWYWQIDLHNLFHFLRLRASAHAQAEIRAYAEVIIEITRAVAPCATASFENHEKDGVQFSGREFAALKALLAGEGLSLEGKERARFEEKLRSGLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83997</accession>
    <name>O83997_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_1034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71250">
        <property type="entry name" value="A71250"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882478.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83997">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1034"/>
    <dbReference type="EnsemblBacteria" id="AAC26588">
        <property type="protein sequence ID" value="AAC26588"/>
        <property type="gene ID" value="TP_1034"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76198">
        <property type="protein sequence ID" value="AGN76198"/>
        <property type="gene ID" value="TPANIC_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1034"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.1022"/>
    <dbReference type="eggNOG" id="COG0530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_0_3_12"/>
    <dbReference type="OMA" id="TRDYGVM"/>
    <dbReference type="OrthoDB" id="804531at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="197"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC26588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="341" mass="35537" checksum="0B2647E20FD4ECE6" modified="1998-11-01" version="1">MESFVRSALAARTLPTLLGVLLCALYFLARSADCLVESASALSRRWGISEALLGATLVSLGTTTPEAAVSVYAALCGNADLALGNAIGSIVVDTGFILGLGALLARPGLALDTHLMRRHARVQLFVVCALGWVTLPRFGARVHQYVGWLFLSLLALYLWVSLRWSALPHAPDTRTAALPADKTDTRSVCRLLLQLGGGIGFLVLGSRVLIPTVEIMALRAGVPAGIIAATIIAFGTSVPELVSAITAVRRGHGALAVGNIVGADILNVLFVVGAAASLTPHGLPVPKIFSLLHLPAMLLVVGIFHACALGRRTLTRPAGVLLCAVYGLFVLLNGLLRGTGP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83998</accession>
    <name>SYV_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Valyl-tRNA synthetase</fullName>
            <shortName evidence="1">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">valS</name>
        <name type="ordered locus">TP_1035</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71250">
        <property type="entry name" value="B71250"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882479.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83998"/>
    <dbReference type="SMR" id="O83998"/>
    <dbReference type="STRING" id="243276.TPANIC_1035"/>
    <dbReference type="EnsemblBacteria" id="AAC26589">
        <property type="protein sequence ID" value="AAC26589"/>
        <property type="gene ID" value="TP_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1035"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_12"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000106241" description="Valine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="885"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="566"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <sequence length="956" mass="107363" checksum="7D50583C7C6BA35A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O84002</accession>
    <name>O84002_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysyl-tRNA synthetase (LysS-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_1040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71250">
        <property type="entry name" value="G71250"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882484.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O84002">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1040"/>
    <dbReference type="EnsemblBacteria" id="AAC26594">
        <property type="protein sequence ID" value="AAC26594"/>
        <property type="gene ID" value="TP_1040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76204">
        <property type="protein sequence ID" value="AGN76204"/>
        <property type="gene ID" value="TPANIC_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="57879551"/>
    <dbReference type="KEGG" id="tpa:TP_1040"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.1028"/>
    <dbReference type="eggNOG" id="COG2269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_1_0_12"/>
    <dbReference type="OMA" id="EWYRPGF"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="14"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC26594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="351" mass="39986" checksum="E2E0EED718D68F29" modified="1998-11-01" version="1">MDTESVLFRAQCLRAVRDFFLEHHYIELDTPALARALVPERCLEVFQTEYFTSVHAKDTQKLYLVPSPEVFLKPLIAQLQRSAFQISKCYRNGESMGALHRPEFTMVEYYTVYADYKTSLDVSSKLFRFVVEQVQSHPLADPYSCACFCAPFEYVTVEEAFLRYAGFSLSHASSVQTLAQEVLRSGIDLGARAGVDYTQWSWDDLYELLLVHIVEPKLRSIKDRCVVLYDYPIQISCLAQEHTGRSGIQSTSPNKGDAPHWVVKERWELYVRGVELINCYTEQRDAKHVTRYCREEQTAKQGSARVVHPVPEGFAHACARMPPCSGAALGFDRLVALLAGRHSLDAFVYDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-08-01" modified="2022-05-25" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P21990</accession>
    <name>FLAB1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin FlaB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Flagellar filament 34.5 kDa core protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">flaB1</name>
        <name type="ordered locus">TP_0868</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="Infect. Immun." volume="58" first="1697" last="1704">
            <title>Cloning, sequencing, and expression of two class B endoflagellar genes of Treponema pallidum subsp. pallidum encoding the 34.5- and 31.0-kilodalton proteins.</title>
            <authorList>
                <person name="Champion C.I."/>
                <person name="Miller J.N."/>
                <person name="Lovett M.A."/>
                <person name="Blanco D.R."/>
            </authorList>
            <dbReference type="PubMed" id="2187805"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1988" name="J. Bacteriol." volume="170" first="4072" last="4082">
            <title>Antigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenis.</title>
            <authorList>
                <person name="Norris S.J."/>
                <person name="Charon N.W."/>
                <person name="Cook R.G."/>
                <person name="Fuentes M.D."/>
                <person name="Limberger R.J."/>
            </authorList>
            <dbReference type="PubMed" id="3045083"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 1-20</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="7700" last="7706">
            <title>Novel conserved assembly factor of the bacterial flagellum.</title>
            <authorList>
                <person name="Titz B."/>
                <person name="Rajagopala S.V."/>
                <person name="Ester C."/>
                <person name="Haeuser R."/>
                <person name="Uetz P."/>
            </authorList>
            <dbReference type="PubMed" id="16936039"/>
            <dbReference type="DOI" id="10.1128/JB.00820-06"/>
        </citation>
        <scope>INTERACTION WITH FLIW</scope>
        <scope>MUTAGENESIS OF ILE-233 AND ASN-237</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Component of the core of the flagella.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides. Interacts via its C-terminus with FliW; a synthetic peptide of residues 229-247 partially blocks binding to FliW (PubMed:16936039).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Periplasmic flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="X63965">
        <property type="protein sequence ID" value="CAA45381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B41489">
        <property type="entry name" value="B41489"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882311.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P21990"/>
    <dbReference type="SMR" id="P21990"/>
    <dbReference type="IntAct" id="P21990">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0868"/>
    <dbReference type="PRIDE" id="P21990"/>
    <dbReference type="EnsemblBacteria" id="AAC65834">
        <property type="protein sequence ID" value="AAC65834"/>
        <property type="gene ID" value="TP_0868"/>
    </dbReference>
    <dbReference type="GeneID" id="57879383"/>
    <dbReference type="KEGG" id="tpa:TP_0868"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_2_0_12"/>
    <dbReference type="OMA" id="IASQTTY"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182634" description="Flagellin FlaB1">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for interaction with FliW" evidence="1">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Peptide of residues 229-247 no longer binds FliW." evidence="1">
        <original>I</original>
        <variation>A</variation>
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Peptide of residues 229-247 no longer binds FliW." evidence="1">
        <original>N</original>
        <variation>A</variation>
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16936039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="2187805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="286" mass="31174" checksum="E2D8C13B052C5CF8" modified="1997-11-01" version="2">MIINHNMSAMFAQRTLGHTNVQVGKGIEKLSSGYRINRAGDDASGLAVSEKMRSQIRGLNQASTNASNGVNFIQVTEAYLQETTDIMQRIRELAIQAANGIYSAEDRMQIQVEVSQLVAEVDRIASSAQFNGMNLLTGRFSRTEGENVIGGSMWFHIGANMDQRMRVYIGTMTAVALGVRNGVDESIMSIETADSANKSIGTIDAALKRINKQRADLGGYQNRMEYTVVGLDIAAENLQAAESRIRDANIAKQMVEYTKNQVLTQSGTAMLAQANTSAQSILSILR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-11-01" modified="2022-08-03" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>P23033</accession>
    <accession>O83073</accession>
    <name>CH60_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Common antigen</fullName>
            <shortName>CA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>TP4 antigen</fullName>
            <shortName>TP-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>TPN60</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="synonym">mopA</name>
        <name type="synonym">Tp4</name>
        <name type="ordered locus">TP_0030</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1990-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hindersson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="J. Bacteriol." volume="172" first="2862" last="2870">
            <title>Isolation and characterization of a Treponema pallidum major 60-kilodalton protein resembling the groEL protein of Escherichia coli.</title>
            <authorList>
                <person name="Houston L.S."/>
                <person name="Cook R.G."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="1971618"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 2-23</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>This is one of the most abundant proteins of T.pallidum and is highly antigenic.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="X54111">
        <property type="protein sequence ID" value="CAA38048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71374">
        <property type="entry name" value="H71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881479.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P23033"/>
    <dbReference type="SMR" id="P23033"/>
    <dbReference type="IntAct" id="P23033">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0030"/>
    <dbReference type="PRIDE" id="P23033"/>
    <dbReference type="EnsemblBacteria" id="AAC65026">
        <property type="protein sequence ID" value="AAC65026"/>
        <property type="gene ID" value="TP_0030"/>
    </dbReference>
    <dbReference type="GeneID" id="57878572"/>
    <dbReference type="KEGG" id="tpa:TP_0030"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_12"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000063587" description="Chaperonin GroEL">
        <location>
            <begin position="2"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA38048." evidence="3" ref="1">
        <original>KQ</original>
        <variation>NE</variation>
        <location>
            <begin position="3"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA38048." evidence="3" ref="1">
        <original>PE</original>
        <variation>GQ</variation>
        <location>
            <begin position="525"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="1971618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="544" mass="57981" checksum="CA0AC145AA96E71E" modified="2007-01-23" version="4"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-08-01" modified="2022-05-25" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>P27771</accession>
    <accession>O83775</accession>
    <name>P5CR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="1">P5C reductase</shortName>
            <shortName evidence="1">P5CR</shortName>
            <ecNumber evidence="1">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proC</name>
        <name type="ordered locus">TP_0797</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1990" name="J. Bacteriol." volume="172" first="2996" last="3002">
            <title>Complementation of an Escherichia coli proC mutation by a gene cloned from Treponema pallidum.</title>
            <authorList>
                <person name="Gherardini F.C."/>
                <person name="Hobbs M.M."/>
                <person name="Stamm L.V."/>
                <person name="Bassford P.J. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="2188947"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>PATHWAY</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="M73825">
        <property type="protein sequence ID" value="AAA27478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71281">
        <property type="entry name" value="D71281"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882242.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P27771"/>
    <dbReference type="SMR" id="P27771"/>
    <dbReference type="IntAct" id="P27771">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0797"/>
    <dbReference type="EnsemblBacteria" id="AAC65760">
        <property type="protein sequence ID" value="AAC65760"/>
        <property type="gene ID" value="TP_0797"/>
    </dbReference>
    <dbReference type="GeneID" id="57879317"/>
    <dbReference type="KEGG" id="tpa:TP_0797"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_12"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187310" description="Pyrroline-5-carboxylate reductase">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1." evidence="3" ref="1">
        <original>MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWI</original>
        <variation>MTWDFWVLEQWDGRWQKGWCTQERCKRSSVRLCVKSGKVACAVYIFGHRCLRVSSGTGTEKVNGF</variation>
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAA27478." evidence="3" ref="1">
        <original>VLRDRQSFQGKVLISLA</original>
        <variation>GTARSPIFQESAISC</variation>
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1." evidence="3" ref="1">
        <original>VRAAL</original>
        <variation>CRWLS</variation>
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="2188947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="263" mass="27645" checksum="ED4AD7C54BAF9D61" modified="1998-12-15" version="2">MNVGFLGFGAMGRALAEGLVHAGALQAAQVYACALNQEKLRAQCTSLGIGACASVQELVQKSEWIFLAVKPSQISTVLRDRQSFQGKVLISLAAGMSCAAYEALFAADPHQGIRHLSLLPNLPCQVARGVIIAEARHTLHHDEHAALLAVLRTVAQVEVVDTAYFAIAGVIAGCAPAFAAQFIEALADAGVRYGLARDQAYRLAAHMLEGTAALIQHSGVHPAQLKDRVCSPAGSTIRGVLALEEQGLRRAVIHAVRAALSSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-07-15" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>P74932</accession>
    <name>FLIR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliR</name>
        <name type="ordered locus">TP_0716</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Gene" volume="166" first="57" last="64">
            <title>Identification and sequences of the Treponema pallidum fliM', fliY, fliP, fliQ, fliR and flhB' genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="8529894"/>
            <dbReference type="DOI" id="10.1016/0378-1119(95)00583-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4509">
        <property type="entry name" value="JC4509"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882161.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74932"/>
    <dbReference type="SMR" id="P74932"/>
    <dbReference type="IntAct" id="P74932">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0716"/>
    <dbReference type="EnsemblBacteria" id="AAC65682">
        <property type="protein sequence ID" value="AAC65682"/>
        <property type="gene ID" value="TP_0716"/>
    </dbReference>
    <dbReference type="GeneID" id="57879241"/>
    <dbReference type="KEGG" id="tpa:TP_0716"/>
    <dbReference type="eggNOG" id="COG1684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063626_2_0_12"/>
    <dbReference type="OMA" id="APQFNIF"/>
    <dbReference type="OrthoDB" id="1942709at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000192058" description="Flagellar biosynthetic protein FliR">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="265" mass="29313" checksum="A9BFA16FEE365C09" modified="1997-02-01" version="1">MERSFDALFSQASLFFLAAVRVFALMFTVPLLSVRSVSRVVRVALAGLIAFLVLPLAYPAPMQVREFSAYYVLLLLGEGLLGILTGFFISVIFTTFSAAGQFFSYQMGFGTSEMYDTFAQIENPLMGQFLNFVAMLVFLQIKGFQILFLGGVLRSFQAVNCFVFLRKQEALLLFFTKALSALFLHAMTIALPIMGALLLIHVSMGLLTKAAPQMNLLSEGLPLTIVVTFVLLSVILPYMINLFVSILFGGFEMFEQLLVKLGKAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>P96130</accession>
    <name>RECG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent DNA helicase RecG</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">recG</name>
        <name type="ordered locus">TP_0687</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1996-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="U70661">
        <property type="protein sequence ID" value="AAB38707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71292">
        <property type="entry name" value="D71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882132.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96130"/>
    <dbReference type="SMR" id="P96130"/>
    <dbReference type="IntAct" id="P96130">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0687"/>
    <dbReference type="EnsemblBacteria" id="AAC65656">
        <property type="protein sequence ID" value="AAC65656"/>
        <property type="gene ID" value="TP_0687"/>
    </dbReference>
    <dbReference type="GeneID" id="57879212"/>
    <dbReference type="KEGG" id="tpa:TP_0687"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_12"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000102161" description="ATP-dependent DNA helicase RecG">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="285"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="472"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEQH box">
        <location>
            <begin position="399"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="298"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="686" mass="77197" checksum="B05AFCDC6FA046B0" modified="1997-05-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q56336</accession>
    <name>CFPA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Cytoplasmic filament protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">cfpA</name>
        <name type="synonym">tpn83</name>
        <name type="ordered locus">TP_0748</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="3177" last="3187">
            <title>Characterization of the cytoplasmic filament protein gene (cfpA) of Treponema pallidum subsp. pallidum.</title>
            <authorList>
                <person name="You Y."/>
                <person name="Elmore S."/>
                <person name="Colton L.L."/>
                <person name="Mackenzie C."/>
                <person name="Stoops J.K."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="8655496"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 2-22 AND 147-162</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Component of the cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text>An array of 4 to 6 filaments lie in close apposition to the inner membrane and are always localized directly underneath the corresponding group of periplasmic flagella.</text>
    </comment>
    <dbReference type="EMBL" id="U32683">
        <property type="protein sequence ID" value="AAB07757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="A71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882193.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56336"/>
    <dbReference type="SMR" id="Q56336"/>
    <dbReference type="IntAct" id="Q56336">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0748"/>
    <dbReference type="PRIDE" id="Q56336"/>
    <dbReference type="EnsemblBacteria" id="AAC65715">
        <property type="protein sequence ID" value="AAC65715"/>
        <property type="gene ID" value="TP_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0748"/>
    <dbReference type="eggNOG" id="ENOG5033SJ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404807_0_0_12"/>
    <dbReference type="OMA" id="TSKMGYQ"/>
    <dbReference type="OrthoDB" id="130662at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000089576" description="Cytoplasmic filament protein A">
        <location>
            <begin position="2"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="8655496"/>
        </source>
    </evidence>
    <sequence length="678" mass="78539" checksum="7910E2AE8A03A41F" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q56343</accession>
    <name>Q56343_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Regulatory protein (PfoS/R)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AAC65034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="E71373"/>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0038"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.34"/>
    <dbReference type="eggNOG" id="COG3641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="IQYSGLG"/>
    <dbReference type="OrthoDB" id="814081at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="350" mass="36923" checksum="78759B06901A1F75" modified="1999-05-01" version="2">MHTQSLSPRQFMMKILNGSSAGIVIGLVPPAIAGELFRALAPLSPLFAALYHVVLPIQFSVPALIGTLVGLQFHCSAPEVATLAFVSVIASGNVTLQNGAWLITGIGDVINVMLISALAIILVRALRGKLGSLTIIALPVIVAVVAGGVGSFSLPYVKMITLFVGRVIATFIALQPLLMSILLSMSFSLIIISPVSSVAVGIAVGLTGLASGAANIGVSSCAMTLIVGTMRVNKIGVPLAMFAGAMKMLMPNWIRYPILNIPLLLNGLVCGVLAWLFNLQGTPASAGFGFIGLVGPINAYRLMAYTPMVRAGILFLVYFVLSFLAAYLIDFILVDRLKLYRRELFIPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUP9</accession>
    <name>F7IUP9_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Treponemal aqueous protein (Tap1)</fullName>
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    </protein>
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        <name evidence="3" type="ordered locus">TP_0729</name>
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        <lineage>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
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            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="F71287"/>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
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    <dbReference type="EnsemblBacteria" id="AAC65699">
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        <property type="gene ID" value="TP_0729"/>
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        <property type="protein sequence ID" value="AGN75903"/>
        <property type="gene ID" value="TPANIC_0729"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG3144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="VLQEVHW"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="425"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="547" mass="56463" checksum="61A7C06CF05349CC" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW78</accession>
    <name>F7IW78_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook assembly scaffolding protein (FlgD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71287">
        <property type="entry name" value="E71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882173.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0728"/>
    <dbReference type="EnsemblBacteria" id="AAC65697">
        <property type="protein sequence ID" value="AAC65697"/>
        <property type="gene ID" value="TP_0728"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75902">
        <property type="protein sequence ID" value="AGN75902"/>
        <property type="gene ID" value="TPANIC_0728"/>
    </dbReference>
    <dbReference type="GeneID" id="57879252"/>
    <dbReference type="KEGG" id="tpa:TP_0728"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.717"/>
    <dbReference type="eggNOG" id="COG1843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047535_1_0_12"/>
    <dbReference type="OMA" id="PQIMIDG"/>
    <dbReference type="OrthoDB" id="709873at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17102" checksum="75AA932FF0DB46A4" modified="2011-07-27" version="1">MVQNTNMRFEMTAAERTRLEMDVRVINKQLEAGARSAKRELGKDDFLHLLIAQLTHQDPTAPMQDTQFIAQMAQFSSLEQMANMSAQVEKLGTLFGNTEALQAVGKMVEVTEADNTVRGLISAVTRADKPQVRVGSHWYEWEHVKVIADPSAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-01-16" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O07896</accession>
    <name>RNZ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Z</fullName>
            <shortName evidence="1">RNase Z</shortName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnz</name>
        <name type="ordered locus">TP_0819</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="1"/>
    <dbReference type="EMBL" id="U93844">
        <property type="protein sequence ID" value="AAB61269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71278">
        <property type="entry name" value="H71278"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O07896"/>
    <dbReference type="SMR" id="O07896"/>
    <dbReference type="IntAct" id="O07896">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0819"/>
    <dbReference type="EnsemblBacteria" id="AAC65782">
        <property type="protein sequence ID" value="AAC65782"/>
        <property type="gene ID" value="TP_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0819"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_12"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000155918" description="Ribonuclease Z">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <sequence length="310" mass="35203" checksum="44BED3F50DE1EEEA" modified="1997-07-01" version="1">MHMNLEAFILGCGGMVPLPHRHLTSVLLRREGELFLFDAGEGTQVSLRRLSLRWKKISAIFISHTHADHITGLPGLLMLSSQVARSEPLYIIGPPRTAEYVETSRRILDMYINYEIIVKEVIEPQVVYRGKDFQVRCFCLDHTKPCMGYTLEEQDRPGSFDPRAAQDLHVPCGALWSQLQSGVAVQSAQGVTVYPEQVMGPARPGRKVSFVTDTKYLQSIAAEVRNSDFFVCEGMFEKGMEKDAAEKKHMTCVQAATIARDARVRLMALIHYSPRYTDHELKRLLKEAQRVFPHTILSRDQLMVPIAYRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83047</accession>
    <name>DNAA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaA</name>
        <name type="ordered locus">TP_0001</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582316">
            <id>O83047</id>
        </interactant>
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
            <label>dnaB</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582316">
            <id>O83047</id>
        </interactant>
        <interactant intactId="EBI-1589991">
            <id>O83213</id>
            <label>TP_0183</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC64999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71377">
        <property type="entry name" value="H71377"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881451.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83047"/>
    <dbReference type="SMR" id="O83047"/>
    <dbReference type="IntAct" id="O83047">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0001"/>
    <dbReference type="EnsemblBacteria" id="AAC64999">
        <property type="protein sequence ID" value="AAC64999"/>
        <property type="gene ID" value="TP_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="57878543"/>
    <dbReference type="KEGG" id="tpa:TP_0001"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_12"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114291" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="464" mass="52966" checksum="D20D337F7D942EAE" modified="1998-11-01" version="1">MDAVGYEVFWNETLSQIRSESTEAEFNMWFAHLFFIASFENAIEIAVPSDFFRIQFSQKYQEKLERKFLELSGHPIKLLFAVKKGTPHGNTAPPKHVHTYLEKNSPAEVPSKKSFHPDLNRDYTFENFVSGEETKFSHSAAISVSKNPGTSYNPLLIYGGVGLGKTHLMQAIGHEIYKTTDLNVIYVTAENFGNEFISTLLNKKTQDFKKKYRYTADVLLIDDIHFFENKDGLQEELFYTFNELFEKKKQIIFTCDRPVQELKNLSSRLRSRCSRGLSTDLNMPCFETRCAILIKKIQNYNSTYPHKAIHISDDVVRLVSENISSNIRDLEGALTKIIAFIEVSGSITIDIVPSLLKEFFLSARPKHITVETILHVVADHFNISYSDLKGKKRNKSVVYPRQIAMFLSKELTELSTTELGIEFGGRDHSTVIYGCQKIEGEILTNPSLQANLDLLKSKVQDSIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83051</accession>
    <name>GYRA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase subunit A</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyrA</name>
        <name type="ordered locus">TP_0005</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC64998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71378">
        <property type="entry name" value="D71378"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881455.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83051"/>
    <dbReference type="SMR" id="O83051"/>
    <dbReference type="IntAct" id="O83051">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0005"/>
    <dbReference type="EnsemblBacteria" id="AAC64998">
        <property type="protein sequence ID" value="AAC64998"/>
        <property type="gene ID" value="TP_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0005"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_12"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <feature type="chain" id="PRO_0000145271" description="DNA gyrase subunit A">
        <location>
            <begin position="1"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="1">
        <location>
            <begin position="531"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <sequence length="813" mass="89926" checksum="1F6A3AE08C43ECC4" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83053</accession>
    <name>Y008_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0008</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0008</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71378">
        <property type="entry name" value="G71378"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83053"/>
    <dbReference type="EnsemblBacteria" id="AAC65004">
        <property type="protein sequence ID" value="AAC65004"/>
        <property type="gene ID" value="TP_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0008"/>
    <dbReference type="HOGENOM" id="CLU_2453730_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202172" description="Uncharacterized protein TP_0008">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <sequence length="89" mass="10402" checksum="729309C9B55D0A3D" modified="1998-11-01" version="1">MTMGFVEYARKIIDGEPRKDDMREALAESFDLFTRDAHWRIAPYLRLKTHEIVPNHVLVYTDTYVLGKFTLPVTDQVLPEGYWALTAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83055</accession>
    <name>O83055_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein B (TprB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71376">
        <property type="entry name" value="H71376"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881460.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83055">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0011"/>
    <dbReference type="EnsemblBacteria" id="AAC65006">
        <property type="protein sequence ID" value="AAC65006"/>
        <property type="gene ID" value="TP_0011"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75235">
        <property type="protein sequence ID" value="AGN75235"/>
        <property type="gene ID" value="TPANIC_0011"/>
    </dbReference>
    <dbReference type="GeneID" id="57878551"/>
    <dbReference type="KEGG" id="tpa:TP_0011"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.11"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="WPNKRSE"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="97"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="436"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="660" mass="71106" checksum="11C5E0907ADE8A82" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83061</accession>
    <name>O83061_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71377">
        <property type="entry name" value="F71377"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881466.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83061">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0017"/>
    <dbReference type="EnsemblBacteria" id="AAC65009">
        <property type="protein sequence ID" value="AAC65009"/>
        <property type="gene ID" value="TP_0017"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75239">
        <property type="protein sequence ID" value="AGN75239"/>
        <property type="gene ID" value="TPANIC_0017"/>
    </dbReference>
    <dbReference type="GeneID" id="57878555"/>
    <dbReference type="KEGG" id="tpa:TP_0017"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.15"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891215_0_0_12"/>
    <dbReference type="OMA" id="CVKFWIN"/>
    <dbReference type="OrthoDB" id="1229969at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="315" mass="36223" checksum="3D86F5D22A567F9F" modified="1998-11-01" version="1">MVARSIRVELESALDLLKQGDLRQAHQDLQDLLQKELDNRDVLYALTGIRFWEDRMQRVHTISGGLSQGEYLVGQWGAFVAYMQKRGGVVEPVMYALRCCVFTYALRFYGSLITGDAREHPAEVYRKTGLCYKALGNYDAARECLEFAVSLEPDSSAILAELADAYALAGDERWSKLYFREALFKGASKLELNLLESDLIFSLIERVKSYGFSGVELLEWLPVYGTLEGVLTAKRELRAVEIGKLKQAIYSLENDLRNEKVSAERRLLRPRLINHFFWLVDHYVNVQEDKRNIDEVLLKIKLLDEAVYHRYVRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83067</accession>
    <name>O83067_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-and chloride-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71376">
        <property type="entry name" value="C71376"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881472.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0023"/>
    <dbReference type="EnsemblBacteria" id="AAC65017">
        <property type="protein sequence ID" value="AAC65017"/>
        <property type="gene ID" value="TP_0023"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75244">
        <property type="protein sequence ID" value="AGN75244"/>
        <property type="gene ID" value="TPANIC_0023"/>
    </dbReference>
    <dbReference type="GeneID" id="57878565"/>
    <dbReference type="KEGG" id="tpa:TP_0023"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.19"/>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006855_3_0_12"/>
    <dbReference type="OMA" id="NERGMWN"/>
    <dbReference type="OrthoDB" id="376209at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="443" mass="48426" checksum="59D69341FC48C683" modified="1998-11-01" version="1">MSRRKQGRELFNSHVGVVLSCVGAAMGLANVWLFPGRLVEFGGVTFLIPYFIFLFGLSRFGLMGEYAFGKTLRCGPVRAFTRVCETHPSCFLRALRGSGWFPVGVLLATCSFYVVIIGWILRYVVFSCTNALAGTQAHDLFYQVAGTSANVPWTLAAIALTACVVSAGVQKGVERGNIIMMVLFYGVLAFITGYIFTLPNAWIGMRRMLAFQSSSLCNPRLWLYALGMSFFSLSLGGAAMVLYGSYMPDTVDIPRTAFQTATLDFLASGMSALCLIPSAWVLGMDVSSGPEFLFVTITRVASQIPMGVMISVLFFLCVLCAALSSAIAMLEVILESFVHTCTVGRRTLTWSLALVVAFVSLPLNASMRVFETFTDIVVVILSPLSALMGSVMIFWVYGAERCRVAINRCARGPLGKWFTPYMRYVYLGLCVMIMVLGVMFGGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83077</accession>
    <name>Y034_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized periplasmic metal-binding protein TP_0034</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0034</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal. Metal-binding component.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71375">
        <property type="entry name" value="D71375"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83077"/>
    <dbReference type="SMR" id="O83077"/>
    <dbReference type="IntAct" id="O83077">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0034"/>
    <dbReference type="EnsemblBacteria" id="AAC65029">
        <property type="protein sequence ID" value="AAC65029"/>
        <property type="gene ID" value="TP_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0034"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_12"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000031907" description="Uncharacterized periplasmic metal-binding protein TP_0034">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="316" mass="35434" checksum="16051C2199BC81AB" modified="1998-11-01" version="1" precursor="true">MQRCSVVAALAGVVFLAQACSLSTPSRITHTDKLPVVVTFNALKELTQMVGGEKIHLVSIVPDGVDSHDFEPKAKHMAFISDAKVIVYNGLGMEPWIHSVLHAARNSGSIRVEAAQGIVPLKAHTRGHTAHHVHAHASHGSAYDPHVWLSVCNAQTMLRTIGKALCKADPQHTRFYKRNARNAAARLEALYKEYRSKFAALSHRYFVTTHAAFGYLCRDFDLQQKSIKDVFNTEEPSIKRLVELVEFSKKHSVRTIFSERGPSEKVARVLAQEIGASVETIYTMEKNEENLSYYERMKHNINRIYRACSKQVTPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83087</accession>
    <name>O83087_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71372">
        <property type="entry name" value="B71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881497.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83087">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0048"/>
    <dbReference type="EnsemblBacteria" id="AAC65044">
        <property type="protein sequence ID" value="AAC65044"/>
        <property type="gene ID" value="TP_0048"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75268">
        <property type="protein sequence ID" value="AGN75268"/>
        <property type="gene ID" value="TPANIC_0048"/>
    </dbReference>
    <dbReference type="GeneID" id="57878589"/>
    <dbReference type="KEGG" id="tpa:TP_0048"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.44"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_6_5_12"/>
    <dbReference type="OMA" id="KNRVMLM"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="143" mass="15063" checksum="A0EE3AC2238CD62A" modified="1998-11-01" version="1">MAKIERRSMNTLIGAGSRISGNVVVPGSVRIEGDVDGDVITTGHVVIGKRARVRGVIRVGSIIVGGMVEGDIVASEAVQVLPSGVILGAVLTRKIVVDEQAFLDGFCYAVADQEGFNKVLKAYLGRKSIHTSAFGYNKYSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83096</accession>
    <name>O83096_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxaloacetate decarboxylase, subunit beta (OadB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71373">
        <property type="entry name" value="C71373"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881506.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83096">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0057"/>
    <dbReference type="EnsemblBacteria" id="AAC65052">
        <property type="protein sequence ID" value="AAC65052"/>
        <property type="gene ID" value="TP_0057"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75277">
        <property type="protein sequence ID" value="AGN75277"/>
        <property type="gene ID" value="TPANIC_0057"/>
    </dbReference>
    <dbReference type="GeneID" id="57878598"/>
    <dbReference type="KEGG" id="tpa:TP_0057"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.54"/>
    <dbReference type="eggNOG" id="COG1883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036168_1_0_12"/>
    <dbReference type="OMA" id="PMIADPK"/>
    <dbReference type="OrthoDB" id="662061at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697285" evidence="9">
        <location>
            <begin position="26"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="469" mass="49480" checksum="7C1BB66060FA0479" modified="1998-11-01" version="1">MNTRLPLRVLQCVLVGLLVCGPLCAATRRPVRASAPVPMVQSCKDTGARCAPASSMREDMRASHGAAPLLSVRKFLLNTWHSTGLYAFFHGVTQVPDLANPQRTHSVFGYQQALLLVVGLLIIYLGAAKGFEPLLLIPIGFGTVFVNIPGAGMYSEHGMLKLIYDAGVGNEFFPMLIFMGIGALTDFGPLIANPKMAVLGAAAQLGVFLTLFGVAALNFVPGIRYSILDACAIAIIGGADGPTSIYVSAKLAPELMAVIAVAAYSYMALVPIIQPPLMRLLTTRKERLIRMKQLRPVSRIERVLFPLVLLLLSVLLIPAASPLIGMIAFGNFVKECGVVERLSKTMANELLNIVSILLSLGVGSQMTPDKIMNPNALGIIVLGLVAFSVATAGGVFMAKLMNLFLSEKINPLIGSAGVSAVPMAARVSNKVGLEEDPSNFLLMHAMGPNVAGVIGTAIAAGVFISAYGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83100</accession>
    <name>RS18_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">TP_0061</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71370">
        <property type="entry name" value="E71370"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881510.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83100"/>
    <dbReference type="SMR" id="O83100"/>
    <dbReference type="IntAct" id="O83100">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0061"/>
    <dbReference type="EnsemblBacteria" id="AAC65056">
        <property type="protein sequence ID" value="AAC65056"/>
        <property type="gene ID" value="TP_0061"/>
    </dbReference>
    <dbReference type="GeneID" id="57878601"/>
    <dbReference type="KEGG" id="tpa:TP_0061"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_0_3_12"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000111254" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="99" mass="11552" checksum="E584804DBF605A36" modified="1998-11-01" version="1">MAEDHPSVDLDTHLSSPRESEESAPKKNRQFYRKKVCRFCTQKLLADYKDPDTLRRFITERGKILPRRITGTCAKHQRRVALEVKRSRAVALLPFVLTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83110</accession>
    <name>CLPB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">clpB</name>
        <name type="ordered locus">TP_0071</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71371">
        <property type="entry name" value="G71371"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881520.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83110"/>
    <dbReference type="SMR" id="O83110"/>
    <dbReference type="IntAct" id="O83110">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0071"/>
    <dbReference type="EnsemblBacteria" id="AAC65062">
        <property type="protein sequence ID" value="AAC65062"/>
        <property type="gene ID" value="TP_0071"/>
    </dbReference>
    <dbReference type="GeneID" id="57878611"/>
    <dbReference type="KEGG" id="tpa:TP_0071"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_12"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000191197" description="Chaperone protein ClpB">
        <location>
            <begin position="1"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Repeat 1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Repeat 2" evidence="2">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="341"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD2" evidence="1">
        <location>
            <begin position="559"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal" evidence="1">
        <location>
            <begin position="784"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="609"/>
            <end position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="878" mass="98981" checksum="7D9E7419E42A2202" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83111</accession>
    <name>O83111_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71368">
        <property type="entry name" value="G71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881521.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83111">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0072"/>
    <dbReference type="EnsemblBacteria" id="AAC65068">
        <property type="protein sequence ID" value="AAC65068"/>
        <property type="gene ID" value="TP_0072"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75291">
        <property type="protein sequence ID" value="AGN75291"/>
        <property type="gene ID" value="TPANIC_0072"/>
    </dbReference>
    <dbReference type="GeneID" id="57878612"/>
    <dbReference type="KEGG" id="tpa:TP_0072"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.70"/>
    <dbReference type="eggNOG" id="COG4545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159829_0_1_12"/>
    <dbReference type="OMA" id="CPDTEPF"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017167">
        <property type="entry name" value="UCP037291_glutaredoxin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037291">
        <property type="entry name" value="UCP037291_gluthr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="90" mass="10088" checksum="6C48A247F7C67533" modified="1998-11-01" version="1">MEKTLTLFGSNHCGQCATALEYLRSNHINFEYVDITGSGKNLKRFLKMRDSMPLFDDVKKEGRIGIPCLSVNDGEQVFLGVEGLDLSAFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83112</accession>
    <name>Y073_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0073</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0073</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71368">
        <property type="entry name" value="H71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881522.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83112"/>
    <dbReference type="SMR" id="O83112"/>
    <dbReference type="IntAct" id="O83112">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0073"/>
    <dbReference type="EnsemblBacteria" id="AAC65078">
        <property type="protein sequence ID" value="AAC65078"/>
        <property type="gene ID" value="TP_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0073"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043273_0_0_12"/>
    <dbReference type="OMA" id="NSAQFML"/>
    <dbReference type="OrthoDB" id="375160at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202187" description="Uncharacterized protein TP_0073">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="254"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01177"/>
        </source>
    </evidence>
    <sequence length="513" mass="58173" checksum="0E05F4ADC3A46C97" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83117</accession>
    <name>O83117_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat polysaccharide biosynthesis protein (SpsC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71369">
        <property type="entry name" value="E71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881527.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83117">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0078"/>
    <dbReference type="EnsemblBacteria" id="AAC65073">
        <property type="protein sequence ID" value="AAC65073"/>
        <property type="gene ID" value="TP_0078"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75297">
        <property type="protein sequence ID" value="AGN75297"/>
        <property type="gene ID" value="TPANIC_0078"/>
    </dbReference>
    <dbReference type="GeneID" id="57878618"/>
    <dbReference type="KEGG" id="tpa:TP_0078"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.78"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_3_12"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="412" mass="45296" checksum="BA48672E2EB476CA" modified="1998-11-01" version="1">MEGTVKKKKEGVRDDNAQHAVFNKQVPFFVPSFSEAEERAVCDVLRSGWITTGTQALAFEKEFAAYVGAPYACAVNSATSGLLLTFDAMGIGPDSKILTSPYTFVSTASSALHLGAQVVYADIERDSYNISAECVEACLKKDARIRAIVPIHIAGNVCNMRDLNALARKYQVAVVEDAAHAFPSKTACGYAGTLSHAGVFSFYATKPLTTGEGGMVCTNDAKLAARIACLRSHGIDRAIWDRYTNGTAPWRYDVTSLGWKCNLPDILAAIGRVQLQKAAHLFAQRARIAAAFTRAFSRYEFFCTPPDGDGNAWHLYLLRLVPGTLSVSRDEFVRLLQERGLGVSMHFIPHFEMTFFKKSLCVRAEDFPECAHKYQHTLTLPLWPGMDDSCVAYVIETVVRTAQECAKGRAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83126</accession>
    <name>O83126_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71368">
        <property type="entry name" value="A71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881537.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83126">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0088"/>
    <dbReference type="EnsemblBacteria" id="AAC65083">
        <property type="protein sequence ID" value="AAC65083"/>
        <property type="gene ID" value="TP_0088"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75307">
        <property type="protein sequence ID" value="AGN75307"/>
        <property type="gene ID" value="TPANIC_0088"/>
    </dbReference>
    <dbReference type="GeneID" id="57878628"/>
    <dbReference type="KEGG" id="tpa:TP_0088"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.88"/>
    <dbReference type="eggNOG" id="ENOG5033HN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094598_0_0_12"/>
    <dbReference type="OMA" id="IRRAFFQ"/>
    <dbReference type="OrthoDB" id="1827957at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23231" checksum="C1816A0D0D6A20BC" modified="1998-11-01" version="1">MNYAKNCMALALGGVLHMQSYLCSSPSPSRGAGGARMLATVTPLSQTHSLEKIPAVYRALSLGMGVTEVKEALKKDSIFGYRGERDVSLLMSENRILIETTGPHFIARSWFQFYRDRLYAMTFKLNTDAIDYYSVYENLCKKYGEPHKLSPRVALWEDASTRLVLERPLIIKYIDIRAFNEQLSARDTQKSNAEKDRKRFVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83140</accession>
    <name>O83140_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71367">
        <property type="entry name" value="B71367"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881551.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83140">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0102"/>
    <dbReference type="EnsemblBacteria" id="AAC65097">
        <property type="protein sequence ID" value="AAC65097"/>
        <property type="gene ID" value="TP_0102"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75321">
        <property type="protein sequence ID" value="AGN75321"/>
        <property type="gene ID" value="TPANIC_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0102"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.102"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_12"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="272"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="657" mass="75462" checksum="6B6970BCBC38EE28" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>O83142</accession>
    <name>5NTD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable 5'-nucleotidase</fullName>
            <ecNumber>3.1.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0104</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71365">
        <property type="entry name" value="E71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881553.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83142"/>
    <dbReference type="SMR" id="O83142"/>
    <dbReference type="IntAct" id="O83142">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0104"/>
    <dbReference type="EnsemblBacteria" id="AAC26552">
        <property type="protein sequence ID" value="AAC26552"/>
        <property type="gene ID" value="TP_0104"/>
    </dbReference>
    <dbReference type="GeneID" id="57878644"/>
    <dbReference type="KEGG" id="tpa:TP_0104"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_1_12"/>
    <dbReference type="OMA" id="VQPFTNM"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006420">
        <property type="entry name" value="NadN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01530">
        <property type="entry name" value="nadN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000000027" description="Probable 5'-nucleotidase">
        <location>
            <begin position="22"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="539"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="3">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="593" mass="64871" checksum="051931037DF33B40" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83146</accession>
    <name>PFKA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="1">ATP-PFK</shortName>
            <shortName evidence="1">Phosphofructokinase</shortName>
            <ecNumber evidence="1">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pfkA</name>
        <name type="synonym">pfk</name>
        <name type="ordered locus">TP_0108</name>
        <name type="ORF">TPANIC_0108</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71366">
        <property type="entry name" value="A71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881557.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83146"/>
    <dbReference type="SMR" id="O83146"/>
    <dbReference type="STRING" id="243276.TPANIC_0108"/>
    <dbReference type="EnsemblBacteria" id="AAC26556">
        <property type="protein sequence ID" value="AAC26556"/>
        <property type="gene ID" value="TP_0108"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75327">
        <property type="protein sequence ID" value="AGN75327"/>
        <property type="gene ID" value="TPANIC_0108"/>
    </dbReference>
    <dbReference type="GeneID" id="57878648"/>
    <dbReference type="KEGG" id="tpa:TP_0108"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0108"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.109"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_7_4_12"/>
    <dbReference type="OMA" id="KFAVICV"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01981">
        <property type="entry name" value="Phosphofructokinase_II_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012004">
        <property type="entry name" value="PyroP-dep_PFK_TP0108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000534">
        <property type="entry name" value="PPi_PFK_TP0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000429713" description="ATP-dependent 6-phosphofructokinase">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="256"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01981"/>
        </source>
    </evidence>
    <sequence length="461" mass="50162" checksum="6A902B8678CC8A54" modified="1998-11-01" version="1">MAHLPKEYDFSIESLGESKIPSPIYLSHTLGDFIPNYVSDNEYISHELSARLGETVGPFTHKNLMERAGPRQKIFFNPHHVHAGIVTCGGLCPGLNDVIRAIVRCLWGRYGVKRISGIRFGYKGLLPDYNFDILPLTPEVIDNCHKTGGSLLGTSRGGGNRVVDIVDGIERLNLHILFIIGGDGSQKGAKEIADEIKHRNLKISIIGIPKTVDNDISFVQKSFGFDTAIVKATEAVAAAHMEARSQINGIGLVKLMGRESGFIATYTAIASHETNFVLIPEVSFDLDGPNGLLAHLEKRIALRKHAVLVVAEGAGQDLMVNADGVPSGDSQGGSLRVSSGTDASGNKRLADIGLFLKEKIGVYFKEKRIHINLKYIDPSYLIRSAVAAPIDSIYCERLGNNAVHAAMCGKTKMIIGLVHNKFVHLPIDVVVCQRKHVNPEGSLWRDALDATGQPIVMKNII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83155</accession>
    <name>Y118_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0118</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0118</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71363">
        <property type="entry name" value="E71363"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881567.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83155"/>
    <dbReference type="SMR" id="O83155"/>
    <dbReference type="STRING" id="243276.TPANIC_0118"/>
    <dbReference type="EnsemblBacteria" id="AAC65114">
        <property type="protein sequence ID" value="AAC65114"/>
        <property type="gene ID" value="TP_0118"/>
    </dbReference>
    <dbReference type="GeneID" id="57878661"/>
    <dbReference type="KEGG" id="tpa:TP_0118"/>
    <dbReference type="eggNOG" id="ENOG5030SAZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_652026_0_0_12"/>
    <dbReference type="OMA" id="RTIKNCE"/>
    <dbReference type="OrthoDB" id="2143486at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202191" description="Uncharacterized protein TP_0118">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="421" mass="46702" checksum="8C7C72BD0C515B6A" modified="1998-11-01" version="1">MFADKSLSALNAACQRAQQDLQSHCCSLGEHIVRGGAACDISGLGVQDTDISRCHALQRQRDQVAESILDIKSILQRQEELAALGKRVSKVLHRHARQERDVLRSFVAQYYATYAHVGLPALEPIYARTAELESTLQDLRAKRDQLLETCTFGSILERVGLQAKSAVVQRRIRVLEAKIQKIITLCTPDVIAHPDVERMYHAGELSSALSAAYARLISDRGVYASNLQHSQELMDEQEALDARLRALDCGAKPLKRVAAFTAQVSELDEDINALCARIGAAYASCFFTEEGFAQPPLSQKTRPTVPDELSTLLRTVAEARMRVARAGYQVECAKLRQKLQSEQRVCESFCRSIEEYRRGIKEYEAMIESAQQNVALSKATVARLAQSLEEASERLTLFETSPEPIVLSSEVLSVPQEKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83156</accession>
    <name>O83156_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter, permease protein (YaeE)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71363">
        <property type="entry name" value="F71363"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881568.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83156">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0119"/>
    <dbReference type="EnsemblBacteria" id="AAC65109">
        <property type="protein sequence ID" value="AAC65109"/>
        <property type="gene ID" value="TP_0119"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75338">
        <property type="protein sequence ID" value="AGN75338"/>
        <property type="gene ID" value="TPANIC_0119"/>
    </dbReference>
    <dbReference type="GeneID" id="57878662"/>
    <dbReference type="KEGG" id="tpa:TP_0119"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.121"/>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077375_0_1_12"/>
    <dbReference type="OMA" id="TFWSAIF"/>
    <dbReference type="OrthoDB" id="1464674at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="219" mass="23021" checksum="D61BEF0D684FAFC3" modified="1998-11-01" version="1">MANQTLWLLVARATGQTSLMVCASASIALAAGTPLGILLCVMSPGHVWAHPAWHRVLSSSMNVLRAFPFVILLVVLLPLSRMLTGRTVGTAAAILPLAIAALPFVARVIESALLEVEPGIIQAAVAMGSSMRQLVLKIMLPEAAPACVSGVALMVINLIGYSAMAGAIGGGGLGDVAIRYGYQRFQPEVMTMAVLAILAQVALTQWIGRIICTRIRARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>O83196</accession>
    <name>Y161_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0161</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0161</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71359">
        <property type="entry name" value="G71359"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83196"/>
    <dbReference type="EnsemblBacteria" id="AAC65153">
        <property type="protein sequence ID" value="AAC65153"/>
        <property type="gene ID" value="TP_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0161"/>
    <dbReference type="HOGENOM" id="CLU_3405986_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202202" description="Uncharacterized protein TP_0161">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <sequence length="30" mass="3259" checksum="4B9A413A5498D15F" modified="1998-11-01" version="1">MSELSAAPLRPGKTQESEKGIYYAREGCVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83213</accession>
    <name>Y183_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0183</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0183</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1589991">
            <id>O83213</id>
        </interactant>
        <interactant intactId="EBI-1582316">
            <id>O83047</id>
            <label>dnaA</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1589991">
            <id>O83213</id>
        </interactant>
        <interactant intactId="EBI-1198617">
            <id>O83634</id>
            <label>sbcD</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71354">
        <property type="entry name" value="A71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881630.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83213"/>
    <dbReference type="IntAct" id="O83213">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0183"/>
    <dbReference type="EnsemblBacteria" id="AAC65196">
        <property type="protein sequence ID" value="AAC65196"/>
        <property type="gene ID" value="TP_0183"/>
    </dbReference>
    <dbReference type="GeneID" id="57878721"/>
    <dbReference type="KEGG" id="tpa:TP_0183"/>
    <dbReference type="eggNOG" id="ENOG502ZI1Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979834_0_0_12"/>
    <dbReference type="OMA" id="NDRRNEN"/>
    <dbReference type="OrthoDB" id="1677534at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014242" description="Uncharacterized protein TP_0183">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="281" mass="31059" checksum="43A3E753FD4DD9C6" modified="1998-11-01" version="1" precursor="true">MKKGVRSSRLLILFVLFAHAVHAAPRVGVYRLEVSGVPAHTETTINDALFSFIRELRGYHVVDCREQAVPHRFPEKGNLDYIFCGAMDLTPEGIRLAVALKGKDHNATRLLSKTYETAARILLDSRHLVRDVFDRSVPLTGNQTETSSMRHTRAGEESVSSLDALAGSWHSTEEGERIVIVSEGRGIAVLRSGLSVPLKLKISDGVLVVSQKGAVNARQFSHFPPEIAQKLAQEARPLQWRFPKISGNNRLSGVRTAPVVRGAGHTASVEYEEVPEEWVRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83220</accession>
    <name>RL4_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">TP_0190</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71354">
        <property type="entry name" value="H71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881637.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83220"/>
    <dbReference type="SMR" id="O83220"/>
    <dbReference type="STRING" id="243276.TPANIC_0190"/>
    <dbReference type="EnsemblBacteria" id="AAC65175">
        <property type="protein sequence ID" value="AAC65175"/>
        <property type="gene ID" value="TP_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0190"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_12"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129304" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="216" mass="24179" checksum="288BE5E35151CB0A" modified="1998-11-01" version="1">MEKTVYSVEGVALRSVELDESVFGLSVNRGVIYYAINSELSNKRLGTACTKGRSEVHGSNTKPYKQKGTGRARRGDKKSPLLVGGGTIFGPKPRDFHYALPKKVKRLAMKSLLSLKAQGDALTVIEDFTVESGKTRDLIQVLRHFAQRERTVFILQNDDALLKRAGRNIPTLSFLSYNRLRAHDLFYGRKVLVLETAVHKIADFYRSKDAAQDGTY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83222</accession>
    <name>RL2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">TP_0192</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71355">
        <property type="entry name" value="B71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881639.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83222"/>
    <dbReference type="SMR" id="O83222"/>
    <dbReference type="IntAct" id="O83222">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0192"/>
    <dbReference type="EnsemblBacteria" id="AAC65177">
        <property type="protein sequence ID" value="AAC65177"/>
        <property type="gene ID" value="TP_0192"/>
    </dbReference>
    <dbReference type="GeneID" id="57878730"/>
    <dbReference type="KEGG" id="tpa:TP_0192"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_12"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129643" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="273" mass="29867" checksum="66F989616C28B1FE" modified="1998-11-01" version="1">MALKMYRPMTAGLRGRVDLCRAELTARTPEKSLTRGKPAKAGRGAGGRISVRHRGGGHKRRYRDIDFKRDLHDIPGTVKTIEYDPNRSVNIALVFYANGQKRYILAPKGLKVGQQVVSGEKVPLEPANALPLGVIPVGFTVHNVELTIGKGGQIARSAGTRAVIAAKDGGYVMLRLPSGEARLVHRRCYATIGELGNEDHMNTALGKAGRARWRGVRPTVRGMAMNPVDHPLGGGEGRGKGRNPVTPWGQPCRGYKTRKKRRVSDRFIVSKRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>O83251</accession>
    <name>Y222_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0222</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0222</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71353">
        <property type="entry name" value="C71353"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881670.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83251"/>
    <dbReference type="SMR" id="O83251"/>
    <dbReference type="IntAct" id="O83251">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0222"/>
    <dbReference type="EnsemblBacteria" id="AAC65211">
        <property type="protein sequence ID" value="AAC65211"/>
        <property type="gene ID" value="TP_0222"/>
    </dbReference>
    <dbReference type="GeneID" id="57878760"/>
    <dbReference type="KEGG" id="tpa:TP_0222"/>
    <dbReference type="HOGENOM" id="CLU_1758026_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014243" description="Uncharacterized protein TP_0222">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="148" mass="16224" checksum="389CE9EB3A5DA0BC" modified="1998-11-01" version="1" precursor="true">MWKRGVGALLWGMVLLRSFVAYADSQAATGGLLKEIMGEVASIRLESNMLKQQLRERHAESAALKKALQTLDVKLEKAAKALEESEHALSESKELIETLRSELEILRQRVNALNMRLRRLEITNNVLIGVAVVCGVAAIGAGIYAAVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83253</accession>
    <name>Y224_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0224</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0224</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71350">
        <property type="entry name" value="F71350"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83253"/>
    <dbReference type="IntAct" id="O83253">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65218">
        <property type="protein sequence ID" value="AAC65218"/>
        <property type="gene ID" value="TP_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0224"/>
    <dbReference type="HOGENOM" id="CLU_3376607_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202214" description="Uncharacterized protein TP_0224">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <sequence length="34" mass="3830" checksum="93D82E14E31DE3A6" modified="1998-11-01" version="1">MRISAGVLNFLKVDLFKGVRHACAPLVWDAYPLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83254</accession>
    <name>Y226_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0226</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0226</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71350">
        <property type="entry name" value="H71350"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881674.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83254"/>
    <dbReference type="SMR" id="O83254"/>
    <dbReference type="IntAct" id="O83254">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0226"/>
    <dbReference type="PRIDE" id="O83254"/>
    <dbReference type="EnsemblBacteria" id="AAC65219">
        <property type="protein sequence ID" value="AAC65219"/>
        <property type="gene ID" value="TP_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0226"/>
    <dbReference type="HOGENOM" id="CLU_1214345_0_0_12"/>
    <dbReference type="OMA" id="MHAGYHI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202215" description="Uncharacterized protein TP_0226">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="228" mass="26203" checksum="71F8AD4EFB0EF6A5" modified="1998-11-01" version="1">MFFSLYERRQSLLHRAPPVAKVASFALLLLCCNAQSWCMHASLTLVLLALTLIVTRSLKCVAAHIRVVSIYLAFFFSLKILHTFFSTGVVSATQINQHIHAGYHIGIRLFLLLCASSLFYACTSRLELFSLCLRMGKVLHVRSTAYTTPCAVYVMMLVLYFGHDIFREWTELRFVWRARTRANTSFYNWVDATLHFSKTLLTRLLERAQHPSLRRADFKVSDNILSSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83264</accession>
    <name>NUSG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusG</name>
        <name type="ordered locus">TP_0236</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71349">
        <property type="entry name" value="F71349"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881684.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83264"/>
    <dbReference type="SMR" id="O83264"/>
    <dbReference type="IntAct" id="O83264">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0236"/>
    <dbReference type="PRIDE" id="O83264"/>
    <dbReference type="EnsemblBacteria" id="AAC65224">
        <property type="protein sequence ID" value="AAC65224"/>
        <property type="gene ID" value="TP_0236"/>
    </dbReference>
    <dbReference type="GeneID" id="57878778"/>
    <dbReference type="KEGG" id="tpa:TP_0236"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_0_12"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0806">Transcription termination</keyword>
    <feature type="chain" id="PRO_0000113967" description="Transcription termination/antitermination protein NusG">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <sequence length="185" mass="20928" checksum="DF9DB89A4A2F9F52" modified="1998-11-01" version="1">MAKEWYILHTFSGREARVERAVRMLVEHARIPTNVIFDIKIPEELLTEVKDGKKRVVRRKFFPGYLLVEMDLPEVDWRIVCNEVRRIPGVSGFLGSSGNAKPQAVSADEARRILQKAGEIKGDRTPRIAQTFLVGQQVRIVEGPFATFSGEVEEVMSERNKVRVAVTIFGRATPVELELVQVEAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83273</accession>
    <name>Y245_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0245</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0245</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71347">
        <property type="entry name" value="H71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881693.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83273"/>
    <dbReference type="SMR" id="O83273"/>
    <dbReference type="STRING" id="243276.TPANIC_0245"/>
    <dbReference type="EnsemblBacteria" id="AAC65239">
        <property type="protein sequence ID" value="AAC65239"/>
        <property type="gene ID" value="TP_0245"/>
    </dbReference>
    <dbReference type="GeneID" id="57878787"/>
    <dbReference type="KEGG" id="tpa:TP_0245"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272728_0_0_12"/>
    <dbReference type="OMA" id="GPAYAMH"/>
    <dbReference type="OrthoDB" id="112519at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202217" description="Uncharacterized protein TP_0245">
        <location>
            <begin position="1"/>
            <end position="1151"/>
        </location>
    </feature>
    <sequence length="1151" mass="127558" checksum="EDB6353C32CB4056" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83286</accession>
    <name>O83286_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catabolite gene activator (Crp)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71347">
        <property type="entry name" value="C71347"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0262"/>
    <dbReference type="EnsemblBacteria" id="AAC65249">
        <property type="protein sequence ID" value="AAC65249"/>
        <property type="gene ID" value="TP_0262"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75474">
        <property type="protein sequence ID" value="AGN75474"/>
        <property type="gene ID" value="TPANIC_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0262"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.266"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_5_12"/>
    <dbReference type="OMA" id="WVKIRTY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="224" mass="26000" checksum="C7B322DDDA598712" modified="1998-11-01" version="1">MRRRRMADAFASFTRFAKKFQRGSVIFAEFDVGESFYLVQSGRVRLIKIINGKERYLDVLQPGEIFGEMSILDNSPRSASAVAYDDVVALEFNRENFEVLMMGNPAIAMRLLKTFVRRIYTQKRRFMILTIQDSTARVGDVFLMLDETQPHVDRSSDARSFDISIEEIARWAGLSDREVQDALRRLSDQRKVEWQERRIVVKNMTDLNRYVTMRRGKGDGLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83292</accession>
    <name>O83292_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71345">
        <property type="entry name" value="F71345"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881717.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83292">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0268"/>
    <dbReference type="EnsemblBacteria" id="AAC65256">
        <property type="protein sequence ID" value="AAC65256"/>
        <property type="gene ID" value="TP_0268"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75479">
        <property type="protein sequence ID" value="AGN75479"/>
        <property type="gene ID" value="TPANIC_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0268"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.272"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094983_0_0_12"/>
    <dbReference type="OMA" id="YINLAPE"/>
    <dbReference type="OrthoDB" id="1380982at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24855" checksum="670CAB2D91BE3FE9" modified="1998-11-01" version="1">MIGFPCRRVALLVARFLLPVVFCFVCRGLCSQQSGLAFYRAGSYREAIRCCEEAIAQGSKDLEHYLVLAWALVAVGKYHEAAQWALEGRAVAAHDPRLIEAQAEAFCHLGRNEEALRLFQDYIACAPNGARQTAAYYLMGEIYLRTSRFLHADIAFSVALQLDSLNDFWWARLGYARERAGDYRYALQAYDRALQLNRDLADARRGRERVLRYVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83318</accession>
    <name>O83318_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carhohydrate kinase (XylB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71345">
        <property type="entry name" value="B71345"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881744.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83318">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0295"/>
    <dbReference type="EnsemblBacteria" id="AAC65274">
        <property type="protein sequence ID" value="AAC65274"/>
        <property type="gene ID" value="TP_0295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75500">
        <property type="protein sequence ID" value="AGN75500"/>
        <property type="gene ID" value="TPANIC_0295"/>
    </dbReference>
    <dbReference type="GeneID" id="57878832"/>
    <dbReference type="KEGG" id="tpa:TP_0295"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.296"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_12"/>
    <dbReference type="OMA" id="PLEVLHW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="414" mass="45555" checksum="7F14D035FE008A70" modified="1998-11-01" version="1">MGSGIFVADIGTSSLKAAIISQDGKVLQYQRVFFPQPVKAQDWVRSFFTVFERLRAVHHVIAITISGNGPSVVAVHKKSHAEDQLILWNQAGASDPRCGVSLFLPKVLLLLQRLHFCARDVQFFLSSHEYLIYRLTGCAVTVLPERRYMPTYWTSESLRACALPETLFAPFVAPGSIVASYRGIPVVCGAPDFAAALIGTNTLHAGSGCDRAGSSEGLNVCVRLPPAIRSADARVRVLPSLRADFWNVSFLIADSGSRFASYMRRTHAQGFGERMGQIMALPFQLHDAYPPTVVGEGRQLVEDLAFEVCAGLEYLESVTQLQPVYTVSGGQAKDSRWLQLKADVSGRCFVLPEIHDAELTGNAALACVALDFDADMQTAAQRLCRLKREFIPNRARHEQYAQKRLLRAAREAQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-03-28" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83324</accession>
    <name>RFUD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable riboflavin import permease protein RfuD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rfuD</name>
        <name evidence="5" type="ordered locus">TP_0302</name>
        <name evidence="6" type="ORF">TPANIC_0302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00615" last="E00615">
            <title>Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Biddy B.A."/>
                <person name="Liu W.Z."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="23404400"/>
            <dbReference type="DOI" id="10.1128/mBio.00615-12"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71341">
        <property type="entry name" value="H71341"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881751.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83324"/>
    <dbReference type="IntAct" id="O83324">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0302"/>
    <dbReference type="TCDB" id="3.A.1.2.28">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65290">
        <property type="protein sequence ID" value="AAC65290"/>
        <property type="gene ID" value="TP_0302"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75506">
        <property type="protein sequence ID" value="AGN75506"/>
        <property type="gene ID" value="TPANIC_0302"/>
    </dbReference>
    <dbReference type="GeneID" id="57878838"/>
    <dbReference type="KEGG" id="tpa:TP_0302"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0302"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.302"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_3_12"/>
    <dbReference type="OMA" id="IARIWVE"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_5007697175" description="Probable riboflavin import permease protein RfuD">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="23404400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000305" key="4">
        <source>
            <dbReference type="PubMed" id="23404400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AGN75506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="313" mass="33534" checksum="F50477AC18D3F46E" modified="1998-11-01" version="1">MGVIGTTVIAILHRAAPLACAAAGALATEYAGVLGIFMEGVITFSSFCIAFFALVWGSYWGGLGITVCVVPLCLFFVAVGTERMRANPFLTGIAVHFSAMGMSAFGASSMFARAAASAMQMDTAAHGVSFTHVSLAHTRVLPHPLWGTAVAFALVWVFHLYLYSTNVGINFMHSGEGALALQVRGTDAARYRMVSWAVAGVCAVCAGGLLVLRVGTYTPQMAAGRGWTALAIVFLARKRMMWCVPAAIFFSGIEHMCDVLQGTHVVPTGVLFALPYILSLVVFVCTRRTSPCRRGERRRSRLLFAYLQRVTCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83326</accession>
    <name>Y304_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0304</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0304</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71342">
        <property type="entry name" value="B71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881753.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83326"/>
    <dbReference type="STRING" id="243276.TPANIC_0304"/>
    <dbReference type="EnsemblBacteria" id="AAC65294">
        <property type="protein sequence ID" value="AAC65294"/>
        <property type="gene ID" value="TP_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0304"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306939_0_0_12"/>
    <dbReference type="OMA" id="MEGSCKK"/>
    <dbReference type="OrthoDB" id="485474at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202230" description="Uncharacterized protein TP_0304">
        <location>
            <begin position="1"/>
            <end position="1039"/>
        </location>
    </feature>
    <sequence length="1039" mass="115874" checksum="E8153EA72D071A5A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83328</accession>
    <name>RS4_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">TP_0306</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71339">
        <property type="entry name" value="D71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881755.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83328"/>
    <dbReference type="SMR" id="O83328"/>
    <dbReference type="STRING" id="243276.TPANIC_0306"/>
    <dbReference type="EnsemblBacteria" id="AAC65295">
        <property type="protein sequence ID" value="AAC65295"/>
        <property type="gene ID" value="TP_0306"/>
    </dbReference>
    <dbReference type="GeneID" id="57878842"/>
    <dbReference type="KEGG" id="tpa:TP_0306"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_4_12"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132486" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="204" mass="23409" checksum="330A58CB5A026955" modified="1998-11-01" version="1">MAVKRARGKIVRRLGINIFGNPKYTRLLGKKPAPPGKEHGVKQRAKVSVYGEQLKEKQKFRFAYGMSERQFRNLFAQAHRMKGVTGNNMLSLMERRLDNTVFRMGFAISRVQARQMVSHRYFLINGKTANIPSMRISAHDVITTKNRKGIHSIIRHNLTLSQGQRGSWLNVDEEQLSATVSELPRAQDIHPVGNIQHIVEYYSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-12-09" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83346</accession>
    <name>TP326_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Putative outer membrane protein assembly factor TP_0326</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TP_92</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tp92</name>
        <name type="ordered locus">TP_0326</name>
        <name type="ORF">TPANIC_0326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="J. Clin. Microbiol." volume="41" first="3668" last="3674">
            <title>Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum.</title>
            <authorList>
                <person name="Van Voorhis W.C."/>
                <person name="Barrett L.K."/>
                <person name="Lukehart S.A."/>
                <person name="Schmidt B."/>
                <person name="Schriefer M."/>
                <person name="Cameron C.E."/>
            </authorList>
            <dbReference type="PubMed" id="12904373"/>
            <dbReference type="DOI" id="10.1128/JCM.41.8.3668-3674.2003"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2011" name="Mol. Microbiol." volume="80" first="1496" last="1515">
            <title>TP0326, a Treponema pallidum beta-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.</title>
            <authorList>
                <person name="Desrosiers D.C."/>
                <person name="Anand A."/>
                <person name="Luthra A."/>
                <person name="Dunham-Ems S.M."/>
                <person name="LeDoyt M."/>
                <person name="Cummings M.A."/>
                <person name="Eshghi A."/>
                <person name="Cameron C.E."/>
                <person name="Cruz A.R."/>
                <person name="Salazar J.C."/>
                <person name="Caimano M.J."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="21488980"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2011.07662.x"/>
        </citation>
        <scope>FUNCTION IN HOST IMMUNE SYSTEM RESPONSE</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
        <scope>DOMAIN</scope>
        <scope>TOPOLOGY</scope>
        <source>
            <strain>Nichols-Farmington</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="J. Clin. Microbiol." volume="51" first="105" last="111">
            <title>New proteins for a new perspective on syphilis diagnosis.</title>
            <authorList>
                <person name="Smith B.C."/>
                <person name="Simpson Y."/>
                <person name="Morshed M.G."/>
                <person name="Cowen L.L."/>
                <person name="Hof R."/>
                <person name="Wetherell C."/>
                <person name="Cameron C.E."/>
            </authorList>
            <dbReference type="PubMed" id="23100335"/>
            <dbReference type="DOI" id="10.1128/JCM.01390-12"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="J. Bacteriol." volume="197" first="1906" last="1920">
            <title>A homology model reveals novel structural features and an immunodominant surface loop/opsonic target in the Treponema pallidum BamA ortholog TP_0326.</title>
            <authorList>
                <person name="Luthra A."/>
                <person name="Anand A."/>
                <person name="Hawley K.L."/>
                <person name="LeDoyt M."/>
                <person name="La Vake C.J."/>
                <person name="Caimano M.J."/>
                <person name="Cruz A.R."/>
                <person name="Salazar J.C."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="25825429"/>
        </citation>
        <scope>FUNCTION IN HOST IMMUNE SYSTEM RESPONSE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>STRUCTURE MODEL</scope>
        <scope>TOPOLOGY</scope>
        <scope>EXPRESSION IN E.COLI</scope>
        <source>
            <strain>Nichols-Farmington</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Might be part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="6 8">Both rabbit immune serum and rabbit antiserum specific for extracytoplasmic loop L4 promote bacteria internalization by rabbit peritoneal macrophages. Pools of human syphilitic sera from the USA and Columbia recognize both the N-terminal POTRA-containing and C-terminal beta-barrel domains as well as loop L4, showing this protein stimulates the immune system in both humans and rabbits (PubMed:25825429).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of 2 complexes of about 239 and 164 kDa.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cell outer membrane</location>
        </subcellularLocation>
        <text evidence="6 8">The C-terminal beta-barrel domain is exposed on the outer surface of the outer membrane (PubMed:21488980). Antibody labeling by antisera to either the periplasmic or membrane domain occurs in a punctate fashion over the length of the spirochete; detection by periplasmic POTRA-domain-specific antibodies only occurs after mild detergent solubilization (PubMed:25825429).</text>
    </comment>
    <comment type="induction">
        <text evidence="6">Transcribed at low levels, estimated to be present at about 100 molecules per cell (at protein level).</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus (residues 22-369) partitions into an aqueous phase and is predicted to be periplasmic, while the C-terminus (residues 426-837) partitions into Triton X-114 and has the hallmarks of a beta-stranded protein, suggesting it is membraneous.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="5 7">Recognized by sera from 42/43 syphilis patients, it shows promise as a diagnostic antigen (PubMed:12904373). In further diagnostic tests for syphilis this protein exhibits a sensitivity of 86% and a specificity of 99%. A fusion with TP0453 (residues 32-287 of TP0453 fused N-terminally to residues 38-450 of TP0326) exhibits a sensitivity of 98% and a specificity of 99%, and exhibits superior accuracy in classifying analytical false-positive samples than a commericially available test, making it a better candiate for diagnosis (PubMed:23100335).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The outer membrane of T.pallidum has no lipopolysaccharides, few proteins and is a fluid and very fragile bilayer. Its lack of surface antigenicity is thought to contribute to the ability of the pathogen to evade the human immune system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the BamA family.</text>
    </comment>
    <comment type="sequence caution" evidence="11">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65313" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <comment type="sequence caution" evidence="11">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AGN75525" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65313.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75525.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71339">
        <property type="entry name" value="A71339"/>
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    <dbReference type="RefSeq" id="WP_014342788.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83346"/>
    <dbReference type="SMR" id="O83346"/>
    <dbReference type="STRING" id="243276.TPANIC_0326"/>
    <dbReference type="EnsemblBacteria" id="AAC65313">
        <property type="protein sequence ID" value="AAC65313"/>
        <property type="gene ID" value="TP_0326"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75525">
        <property type="protein sequence ID" value="AGN75525"/>
        <property type="gene ID" value="TPANIC_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0326"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0326"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.324"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_1_1_12"/>
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    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
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    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
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    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
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    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
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        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004161024" description="Putative outer membrane protein assembly factor TP_0326">
        <location>
            <begin position="22"/>
            <end position="837"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="22"/>
            <end position="433"/>
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    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=1" evidence="10">
        <location>
            <begin position="434"/>
            <end position="442"/>
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    </feature>
    <feature type="topological domain" description="Extracellular; loop L1" evidence="11">
        <location>
            <begin position="443"/>
            <end position="450"/>
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    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=2" evidence="10">
        <location>
            <begin position="451"/>
            <end position="461"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="462"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=3" evidence="10">
        <location>
            <begin position="469"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular; loop L2" evidence="11">
        <location>
            <begin position="477"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=4" evidence="10">
        <location>
            <begin position="479"/>
            <end position="489"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="490"/>
            <end position="499"/>
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    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=5" evidence="10">
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            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular; loop L3" evidence="11">
        <location>
            <begin position="521"/>
            <end position="530"/>
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    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=6" evidence="10">
        <location>
            <begin position="531"/>
            <end position="543"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=7" evidence="10">
        <location>
            <begin position="555"/>
            <end position="568"/>
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    <feature type="topological domain" description="Extracellular; loop L4" evidence="13">
        <location>
            <begin position="569"/>
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    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=8" evidence="10">
        <location>
            <begin position="602"/>
            <end position="615"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="616"/>
            <end position="623"/>
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    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=9" evidence="10">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular; loop L5" evidence="11">
        <location>
            <begin position="637"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=10" evidence="10">
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            <end position="658"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
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            <end position="667"/>
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    <feature type="transmembrane region" description="Beta stranded; Name=11" evidence="10">
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            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular; loop L6" evidence="11">
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            <begin position="683"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=12" evidence="10">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="737"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=13" evidence="10">
        <location>
            <begin position="742"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular; loop L7" evidence="11">
        <location>
            <begin position="757"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=14" evidence="10">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="800"/>
            <end position="802"/>
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    <feature type="transmembrane region" description="Beta stranded; Name=15" evidence="10">
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            <begin position="803"/>
            <end position="814"/>
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    </feature>
    <feature type="topological domain" description="Extracellular; loop L8" evidence="11">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Beta stranded; Name=16" evidence="10">
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            <begin position="825"/>
            <end position="829"/>
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    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="11">
        <location>
            <begin position="830"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 1" evidence="3 12">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 2" evidence="3">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 3" evidence="3">
        <location>
            <begin position="185"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 4" evidence="3">
        <location>
            <begin position="276"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA 5" evidence="3">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="12904373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="21488980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="23100335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="25825429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="12904373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="25825429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000305" key="12">
        <source>
            <dbReference type="PubMed" id="21488980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="13">
        <source>
            <dbReference type="PubMed" id="25825429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAC65313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000014259"/>
        </source>
    </evidence>
    <sequence length="837" mass="94267" checksum="10DA39487F828FBC" modified="2015-12-09" version="2" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="147" xmlns="http://uniprot.org/uniprot">
    <accession>O83364</accession>
    <name>O83364_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">TP_0344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71335">
        <property type="entry name" value="G71335"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881792.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83364">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0344"/>
    <dbReference type="EnsemblBacteria" id="AAC65332">
        <property type="protein sequence ID" value="AAC65332"/>
        <property type="gene ID" value="TP_0344"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75542">
        <property type="protein sequence ID" value="AGN75542"/>
        <property type="gene ID" value="TPANIC_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0344"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.342"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_12"/>
    <dbReference type="OMA" id="SHVVHIN"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="614"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="800"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129971" checksum="DAE28354C8D23ECF" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83375</accession>
    <name>O83375_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71334">
        <property type="entry name" value="B71334"/>
    </dbReference>
    <dbReference type="IntAct" id="O83375">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0356"/>
    <dbReference type="EnsemblBacteria" id="AAC65342">
        <property type="protein sequence ID" value="AAC65342"/>
        <property type="gene ID" value="TP_0356"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75553">
        <property type="protein sequence ID" value="AGN75553"/>
        <property type="gene ID" value="TPANIC_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0356"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.355"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_12"/>
    <dbReference type="OMA" id="LPWNTTA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11956" checksum="D52539FCAB638B02" modified="1998-11-01" version="1">MERGNPIAVERRRFCVMSAKIYVGNLNYATTEAGLASLFSQFGEVLSVAVIKDKLTQRSKGFGFVEMESAESAELVINELNEKEFEGRRLRVNYAEEKPRFPFKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83383</accession>
    <name>Y368_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0368</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0368</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71332">
        <property type="entry name" value="G71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881816.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83383"/>
    <dbReference type="SMR" id="O83383"/>
    <dbReference type="IntAct" id="O83383">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0368"/>
    <dbReference type="EnsemblBacteria" id="AAC65359">
        <property type="protein sequence ID" value="AAC65359"/>
        <property type="gene ID" value="TP_0368"/>
    </dbReference>
    <dbReference type="GeneID" id="57878896"/>
    <dbReference type="KEGG" id="tpa:TP_0368"/>
    <dbReference type="eggNOG" id="ENOG5031CYV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2157257_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202242" description="Uncharacterized protein TP_0368">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="111" mass="12400" checksum="D7F9500F74D63CF9" modified="1998-11-01" version="1">MRLRGVAGALLGAVVLVALGLMGVWWVFYPKKGDRGAAVAREPVLLHIDPAQMEAADEPLTLPPIERSRERMSAWSEQECLRQLEYPTEKAVQALEHANEKRIQQMLEAVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83389</accession>
    <name>Y374_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0374</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0374</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71333">
        <property type="entry name" value="E71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881822.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83389"/>
    <dbReference type="SMR" id="O83389"/>
    <dbReference type="IntAct" id="O83389">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0374"/>
    <dbReference type="EnsemblBacteria" id="AAC65362">
        <property type="protein sequence ID" value="AAC65362"/>
        <property type="gene ID" value="TP_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0374"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392278_0_0_12"/>
    <dbReference type="OMA" id="YETHEPI"/>
    <dbReference type="OrthoDB" id="1014561at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202244" description="Uncharacterized protein TP_0374">
        <location>
            <begin position="1"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="791" mass="89452" checksum="FD1D1ABD59ED2D34" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83399</accession>
    <name>RSMH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">TP_0384</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71331">
        <property type="entry name" value="B71331"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881832.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83399"/>
    <dbReference type="SMR" id="O83399"/>
    <dbReference type="IntAct" id="O83399">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0384"/>
    <dbReference type="EnsemblBacteria" id="AAC65368">
        <property type="protein sequence ID" value="AAC65368"/>
        <property type="gene ID" value="TP_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0384"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_12"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000108737" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="379" mass="40937" checksum="AA7DD603FC12CB74" modified="1998-11-01" version="1">MSLSGHTHTKEEVQAEVEAGEVQCPALCHQPVLVQECLTLLEPAIVGISRGADSTRDGAGAFFIDGTLGDGGHTQAFLHAYPALRALGVEIDPSMLARARARLTPFGKRLRYVLGWSDVFFASAYASAPASPATGRTAAGAAGVPGAYPAPQAVLLDLGISFFHYRGAMRGFSFAEEHMLDMRLDPQASQTAADLLNRLPQARLAQLFFEGGEERYARRIAQAVCAQRRQAPFCSARAFAEVVARVVPPMRTARFGKRRGVLGVLPKLHPATKAFQALRIAVNRELERLPRLLTAAFTALAPGGRLAVISFHSREDRIVKVHFRHWAKRCSCPARVPICSCGGVARASLITKKPLVPSCVERAANAASRSATLRVIEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83408</accession>
    <name>O83408_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Smf protein (Smf)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71332">
        <property type="entry name" value="C71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881841.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83408">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0393"/>
    <dbReference type="EnsemblBacteria" id="AAC65377">
        <property type="protein sequence ID" value="AAC65377"/>
        <property type="gene ID" value="TP_0393"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75587">
        <property type="protein sequence ID" value="AGN75587"/>
        <property type="gene ID" value="TPANIC_0393"/>
    </dbReference>
    <dbReference type="GeneID" id="57878919"/>
    <dbReference type="KEGG" id="tpa:TP_0393"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.393"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_3_1_12"/>
    <dbReference type="OMA" id="YSKQHTI"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33105" checksum="6D88ED703BDC84AF" modified="1998-11-01" version="1">MNTDTVLTETHKIALALSYCHFLKGGERLRVSKAVGSFQELTAWKVRDFERVVERHIRTAGAQLSALPHLVRHGIQTMRCYQIKMVFKDDDAFPSWLREISDVPFVLFYRGTLPCATQPIVGMVGTRTPTGEGVRNSLAFSKACAESGIAIVSGLARGIDGFCHKGALAGGGYTLAVLACGVDQLYPRSNSALAARIIETGGCILSEYAPSEHVMRYRFPERNRLISGLARSLVVMEAPKKSGALITALCALEQGRDVYVYEPLLESLQNEGGRLLHAEGARALTCVQDMFDDWEYACTGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83422</accession>
    <name>O83422_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase (Gph-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71329">
        <property type="entry name" value="F71329"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881855.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83422">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0407"/>
    <dbReference type="EnsemblBacteria" id="AAC65394">
        <property type="protein sequence ID" value="AAC65394"/>
        <property type="gene ID" value="TP_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0407"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.432"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_12"/>
    <dbReference type="OMA" id="FPIATRV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="224" mass="25516" checksum="6644526B6F890C04" modified="1998-11-01" version="1">MAFDIDGTLYPGWRLALRVMPFMIRNARLMRAFRAVRQELRREQRTALIPFEDFFFAQATRIAPRVGLSAEEVRAFLDTALYRGWRRHFLHIKPFPHVLSSVLELRRHGLKIALLSDFPPSQKGCLWGVRALCDVTLGTEEIGSLKPSPRAFYALAQRLNLRCEEILYVGNSVHDVEGAHAAGMRIACVRRPFTSLRVRRTRGLALFRLSHIVRICDSMSAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O83431</accession>
    <name>O83431_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal recognition particle protein (Ffh)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71327">
        <property type="entry name" value="F71327"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881864.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0416"/>
    <dbReference type="EnsemblBacteria" id="AAC65403">
        <property type="protein sequence ID" value="AAC65403"/>
        <property type="gene ID" value="TP_0416"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75611">
        <property type="protein sequence ID" value="AGN75611"/>
        <property type="gene ID" value="TPANIC_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0416"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.415"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_12"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="452" mass="49258" checksum="CBCA66F80AD77583" modified="1998-11-01" version="1">MFEQLSASFKRIVGALGGRATISERNIQEAVESIKRALLDADVHVRVVRRFVNQTIQHAQGQTVLASVSPAQQFIKIVHERLTAFLGEHTRSLHLKGPDTQSIILLLGLQGSGKTTSAAKLAAYLKDAGRSPLLAACDHVRAAASAQLAVLGTHIGVPVYQHALPHEQQPCALDTARGALQYARSHGNDVLIIDTAGRLHVDAALMQELILLKETLVPVETLLVADALTGQTVVRIAEEFHAAVGISGVVLSKFDSDTRGGAALSLKSITGQPLLFVGTGERPQDFEPFHPERAAGRILGMGDIVSLVEKAQKAFDAQEHARAQKKTQSHERFTLSDMLDHLQTIEKMGPLHSLVEMIPGLAVAVSADALDARAFKRQKAIIQSMTVQERDNFLIIGPSRRRRIAAGSGTSVADVNRLIKNFERMRTLMRKTAWQSRRAHPKGDTPYGWPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83450</accession>
    <name>O83450_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71323">
        <property type="entry name" value="D71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881884.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0436"/>
    <dbReference type="EnsemblBacteria" id="AAC65424">
        <property type="protein sequence ID" value="AAC65424"/>
        <property type="gene ID" value="TP_0436"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75629">
        <property type="protein sequence ID" value="AGN75629"/>
        <property type="gene ID" value="TPANIC_0436"/>
    </dbReference>
    <dbReference type="GeneID" id="57878960"/>
    <dbReference type="KEGG" id="tpa:TP_0436"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.434"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_12"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="2">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="3">
        <location>
            <begin position="215"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="360" mass="38168" checksum="3B8D0F2EB8DAEC71" modified="1998-11-01" version="1">MFSSSPPSSLPKSVSSPSPCAARTGDRGRGLSGLIEFIDAHRAFAVVGHEKPDGDCVGSSLALASFLRRIGKEVELLSAGPFKRREIAAYATLFRPSLSAQIRPSDQTAVIVVDCSELSRVGAELASQLAPFARAFIDHHETCGDHCAHSFVVKTAPSTTTLVQTLIETMAGSLEAAEARALFLGLATDTGFFRHLDEHSADTFASAARLVRAGANPKDTFLAMNGGRSLASRMLIARVLSRLTPYYGGALMTSYETCEDAVQLGLDVRDSDALYQLIQSIQGVEAIVVVRQESPTHCSVGFRSRGSIDVSVIAARFGGGGHRCAAGLRIEGTVDELLPRFVAAFEAQMRAPAAGAQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83457</accession>
    <name>O83457_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71324">
        <property type="entry name" value="C71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881891.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83457">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0443"/>
    <dbReference type="EnsemblBacteria" id="AAC65430">
        <property type="protein sequence ID" value="AAC65430"/>
        <property type="gene ID" value="TP_0443"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75636">
        <property type="protein sequence ID" value="AGN75636"/>
        <property type="gene ID" value="TPANIC_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0443"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.472"/>
    <dbReference type="eggNOG" id="ENOG5032X70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089660_0_0_12"/>
    <dbReference type="OMA" id="CYGENSK"/>
    <dbReference type="OrthoDB" id="1286839at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="284" mass="33041" checksum="8C931A51B5A0BE0C" modified="1998-11-01" version="1">MRRSCCAQVRGREGGSAVTEEEQNALYQKKLNVYQGTIDQIFTREKNILELIRRDGTGAAYKKLALVDDMIYLSTLYAAKYQTQVVVVGGKQEDLLNEARKTLYKALIYLEEIVTNLIDTPFSDYQEQVAQIANVSQQQRYYLIRKMGLAIDSIISAYGTNTKWYWSFVELQARYATVAKNILDLANSSEIGLNPQADEYETVVYHLRLVKKLLLQAAERYREKYEMTSSSFEDFKLAVCYLHALRRVHLLLNERQDAEEVKKKAKVWSERMEKDQRKRDRSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83459</accession>
    <name>O83459_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme (ThiJ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71324">
        <property type="entry name" value="E71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881893.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83459">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0445"/>
    <dbReference type="EnsemblBacteria" id="AAC65432">
        <property type="protein sequence ID" value="AAC65432"/>
        <property type="gene ID" value="TP_0445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75638">
        <property type="protein sequence ID" value="AGN75638"/>
        <property type="gene ID" value="TPANIC_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0445"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.443"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_2_12"/>
    <dbReference type="OMA" id="TSYPAMK"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="209" mass="22045" checksum="CD210179DC45347E" modified="1998-11-01" version="1">MSVRVYLFVAHGFEEVETITPLDYLRRAGIALTLVGVGAEQVVSTRGLRVSCDCSLEALCASPGIADAACAADAVLLPGGLENCHTLAACAAVRDFVMRVHLRGGLVAALCAAPARVLSAWNLLGSRRYTCYPGMEPAVFSAHDDGVGKRTEEEKSRALRKPERARVVRDGNLLTACAAGAAEEFSFAVIEALCGVEVAQSVRAQVVAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83466</accession>
    <name>SYI_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="1">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ileS</name>
        <name type="ordered locus">TP_0452</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71322">
        <property type="entry name" value="E71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881901.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83466"/>
    <dbReference type="SMR" id="O83466"/>
    <dbReference type="IntAct" id="O83466">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0452"/>
    <dbReference type="PRIDE" id="O83466"/>
    <dbReference type="EnsemblBacteria" id="AAC65439">
        <property type="protein sequence ID" value="AAC65439"/>
        <property type="gene ID" value="TP_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0452"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_12"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000098569" description="Isoleucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="625"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124242" checksum="30FCAE18C6F301A2" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83483</accession>
    <name>O83483_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71321">
        <property type="entry name" value="H71321"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881919.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83483">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0470"/>
    <dbReference type="EnsemblBacteria" id="AAC65451">
        <property type="protein sequence ID" value="AAC65451"/>
        <property type="gene ID" value="TP_0470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75662">
        <property type="protein sequence ID" value="AGN75662"/>
        <property type="gene ID" value="TPANIC_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0470"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.502"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038824_1_0_12"/>
    <dbReference type="OMA" id="NRANTRI"/>
    <dbReference type="OrthoDB" id="1309037at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697170" evidence="4">
        <location>
            <begin position="36"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="369" mass="43304" checksum="7798B1E8D9788D81" modified="1998-11-01" version="1">MCQKSSPCTYARVRSLPSVRLFSFLALAFASFLRAEDAFDHFREGERLLSLQQAQQAIGPLHKAAQQKPAHPKAALYLGMAYLQTGRYTQAIQWLQNPPVHSQEYAHLYAYNLGNVYFVQHRYEEAQHAYEQALALKHDYPPALLNRANTAMKRQAYAHALADYKKYVSQNPTASQHYEVQRMIAALEQWLQRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEEARRKEAEFEALKRALRLKQAEDARTLSTGSEDTVPYQEEHNLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-11-02" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83488</accession>
    <name>G6PI_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="synonym">gpi</name>
        <name type="ordered locus">TP_0475</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71319">
        <property type="entry name" value="A71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881924.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83488"/>
    <dbReference type="SMR" id="O83488"/>
    <dbReference type="STRING" id="243276.TPANIC_0475"/>
    <dbReference type="EnsemblBacteria" id="AAC65462">
        <property type="protein sequence ID" value="AAC65462"/>
        <property type="gene ID" value="TP_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0475"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_12"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180761" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="535" mass="58418" checksum="44C251C52ECEE33A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83490</accession>
    <name>6PGL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>6-phosphogluconolactonase</fullName>
            <shortName>6PGL</shortName>
            <ecNumber>3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pgl</name>
        <name type="synonym">devB</name>
        <name type="ordered locus">TP_0477</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71319">
        <property type="entry name" value="C71319"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881926.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83490"/>
    <dbReference type="SMR" id="O83490"/>
    <dbReference type="STRING" id="243276.TPANIC_0477"/>
    <dbReference type="EnsemblBacteria" id="AAC65464">
        <property type="protein sequence ID" value="AAC65464"/>
        <property type="gene ID" value="TP_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0477"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_4_0_12"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000090109" description="6-phosphogluconolactonase">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="241" mass="27272" checksum="148FBDA12324FEF9" modified="1998-11-01" version="1">MKKHIFEDARAIAAFLVSVFDSRLKTQEILWLALSGGSTPREIFRTWAHEFRHHLDWKRLRFFWSDERCVPPTDAQSNFNMTHSALLEPLEINPDAVFRVRGEDAPESACAAYSQEIEARLPRQRGVPCFDIILLGMGADGHTASIFPHEIELWDHSGCCVVATHPDTGQKRVSFTGHLINNAHEIYVVVTGREKQDMLASVASDPHASVPLHAWTLPKRSGCWIPLLRGLYPRKQCKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83498</accession>
    <name>O83498_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71320">
        <property type="entry name" value="C71320"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881934.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83498">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0485"/>
    <dbReference type="EnsemblBacteria" id="AAC65466">
        <property type="protein sequence ID" value="AAC65466"/>
        <property type="gene ID" value="TP_0485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75676">
        <property type="protein sequence ID" value="AGN75676"/>
        <property type="gene ID" value="TPANIC_0485"/>
    </dbReference>
    <dbReference type="GeneID" id="57879005"/>
    <dbReference type="KEGG" id="tpa:TP_0485"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.482"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016487_0_0_12"/>
    <dbReference type="OMA" id="RIGCGIN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="393"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="614" mass="67030" checksum="DB30561FE1071BC5" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83499</accession>
    <name>O83499_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antigen, p83/100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71317">
        <property type="entry name" value="F71317"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0486"/>
    <dbReference type="EnsemblBacteria" id="AAC65474">
        <property type="protein sequence ID" value="AAC65474"/>
        <property type="gene ID" value="TP_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0486"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483897_0_0_12"/>
    <dbReference type="OMA" id="YRIIHAV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007926">
        <property type="entry name" value="Borrelia_P83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05262">
        <property type="entry name" value="Borrelia_P83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="484" mass="53376" checksum="30F0D0023497A189" modified="1998-11-01" version="1">MKNVLPMCAVLGAGCLFALEVDRRELERANATVEFENFAGTHTDVDSAAAIRRIGEGLASALRGGVAGDRARYALIHAVGPHTTNGFDADILIIGAQARVDHIDNIREIVAAYLSAAYGYRLQDARTIATFTTVYNAVYRADLPTFKARYKGVVTAHLSPEHVGIARRFDQWPGKTQLVIPLSGHSDALSAVDTGAISDKRVVERLREDPDKNVDLRRDMIDLKEREAQEGTRRAQQLAQQSQQAQERAAELSTQAQRAQAHADKTRREAQQAQQAAQNSPDPARTQEAKEKERVAERAQQEAQQAAHTAQKATEQAESLAREARSQEQRAQQKSAEAQRERLEVAGDMQRMMNAGRAKATHGAQEARESVTPCYGLKVVDAQHLLSEIVLVDPKTEAPLRSSSLRTVRNRLLYSEPHALVAIADTTGNGTVRLVHIDPKTLEVTKESTQRIAAQSFLLRERGALLCGDRRKWQPLPGTLYQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83543</accession>
    <name>O83543_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type ATPase, subunit F, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71313">
        <property type="entry name" value="E71313"/>
    </dbReference>
    <dbReference type="IntAct" id="O83543">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0531"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65518">
        <property type="protein sequence ID" value="AAC65518"/>
        <property type="gene ID" value="TP_0531"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75719">
        <property type="protein sequence ID" value="AGN75719"/>
        <property type="gene ID" value="TPANIC_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0531"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.527"/>
    <dbReference type="eggNOG" id="COG1436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_2_1_12"/>
    <dbReference type="OMA" id="TEWQISG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12494" checksum="F7031847DCDD8FD6" modified="1998-11-01" version="1">MRLGCHQVTYCIIGEQELVLGFSLVGVHGFVVHSPEEAARAFSQVTRPPSGDRPAQVLILTQRAMSYLREEVRAWQMQGELPFVVEVPALHEQGNVRTSLRESIRQVIGAKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83548</accession>
    <name>TPIS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="synonym">tpi</name>
        <name type="ordered locus">TP_0537</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71311">
        <property type="entry name" value="F71311"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881984.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83548"/>
    <dbReference type="SMR" id="O83548"/>
    <dbReference type="IntAct" id="O83548">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0537"/>
    <dbReference type="EnsemblBacteria" id="AAC65522">
        <property type="protein sequence ID" value="AAC65522"/>
        <property type="gene ID" value="TP_0537"/>
    </dbReference>
    <dbReference type="GeneID" id="57879061"/>
    <dbReference type="KEGG" id="tpa:TP_0537"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_12"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000090308" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="249" mass="26540" checksum="EF65741D5EE4D431" modified="1998-11-01" version="1">MRGYFIAGNWKMHKTCAEAVALAQELVRELRGGPHTYMIAPSFTALDAVGKVLRGSNVLLGAQDVSSEEWGAHTGEVSVLQLEDLGVQVVIVGHSERRHGRGENDKLINQKVRRVLESGLRVILCVGERLQEYEAGCTNEVVGTQVRAGMADVCGSLMHNVTVAYEPVWAIGTGKTATPAQANAVHAHIRSVVREMYGAAIAEALCIQYGGSMKAENARALLAEEHIDGGLIGGASLEAASFVPIARSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83585</accession>
    <name>RF2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Peptide chain release factor 2</fullName>
            <shortName>RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">prfB</name>
        <name type="ordered locus">TP_0576</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71306">
        <property type="entry name" value="F71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882022.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83585"/>
    <dbReference type="SMR" id="O83585"/>
    <dbReference type="IntAct" id="O83585">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0576"/>
    <dbReference type="EnsemblBacteria" id="AAC65552">
        <property type="protein sequence ID" value="AAC65552"/>
        <property type="gene ID" value="TP_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0576"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_12"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166855" description="Peptide chain release factor 2">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="368" mass="41596" checksum="B8CBE848BE674A4E" modified="1998-11-01" version="1">MVHKSPPSRRACRKYGGVFDVAAYEARIATLEAAAAAPDFWSERARAEALLAELKTLRATLEPWRALRRESADLRALYELAREAQDASLEPELSSLFSDISARFEEASLTRLLHEEVDRLDAFVTIHSGAGGVEACDWAQMLMRMYTRWAERRSFCVHIVDLLESEGGVKSVTLKICGSHAFGFLKGETGVHRLVRISPFDSAARRHTSFTSTYVFPVLDDHVEVHIRSEDMRVDTYRSGGAGGQHVNKTDSAVRITHLPTGIVVTCQNERSQISNRATALSLLRARLYAYERQKKQQEHQRFASEKKDISWGNQIRSYVFHPYTMVKDHRSKCETGNIHAVMDGALEPFIRSYLEFLCTSTQCVEPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83588</accession>
    <name>Y579_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0579</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0579</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71307">
        <property type="entry name" value="A71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882025.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83588"/>
    <dbReference type="IntAct" id="O83588">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0579"/>
    <dbReference type="EnsemblBacteria" id="AAC65559">
        <property type="protein sequence ID" value="AAC65559"/>
        <property type="gene ID" value="TP_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0579"/>
    <dbReference type="HOGENOM" id="CLU_1077441_0_0_12"/>
    <dbReference type="OMA" id="IRPRHGW"/>
    <dbReference type="OrthoDB" id="2054766at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202278" description="Uncharacterized protein TP_0579">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="258" mass="29464" checksum="93E24DB5527CED6F" modified="1998-11-01" version="1">MIRPRYGWMYSSGIAVHLCAAVCAHSAVPAAWTFAEQTQAQKTDTPLDSSSYAVTSPEEAPNEADPFEKELEHAFERAHVSTGGADSSSHADFVHMEEAGRAHASANRWYHETFDSRQRPSSAVLYEGAQLLHTVHWHYVGDRLFPCEKIITTPHTRIRARYNFSGKIVAYEMHTRGVLVYARTYRYDAHARICEKEETTARGNERITYEYRGKVDVLEKRYRNGVLQAIIHQKEGAQDVQVFERGKEIYSTKEVHDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83596</accession>
    <name>Y587_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0587</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0587</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71305">
        <property type="entry name" value="D71305"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83596"/>
    <dbReference type="IntAct" id="O83596">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0587"/>
    <dbReference type="EnsemblBacteria" id="AAC65569">
        <property type="protein sequence ID" value="AAC65569"/>
        <property type="gene ID" value="TP_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0587"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2653420_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202281" description="Uncharacterized protein TP_0587">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <sequence length="76" mass="8551" checksum="E9A39C49A18C76B9" modified="1998-11-01" version="1">MIAQYQRAASLWTLSDTHAILDRLFQTDAMIRSGGTPLQGPLMQLCLYAIVVHAGRAPHRYCTTLQEQCGLQNEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83597</accession>
    <name>O83597_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol3_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71305">
        <property type="entry name" value="E71305"/>
    </dbReference>
    <dbReference type="IntAct" id="O83597">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65563">
        <property type="protein sequence ID" value="AAC65563"/>
        <property type="gene ID" value="TP_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0588"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.627"/>
    <dbReference type="HOGENOM" id="CLU_1093902_0_0_12"/>
    <dbReference type="OMA" id="WQFKRLL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="15"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="254" mass="29125" checksum="6FC820D5F5FB237B" modified="1998-11-01" version="1">MSVWLFTGPEIGERDSAVQEVCARAQAQGTVDVHRLYAHETPVADLVDLLRTRALFADAVCVVLYNAEVIKKCDEVHVLTEWIKDGGSRADVFLVLISDSVSIHKRIEQNISPVHKRVFWELFENKKHAWVQRFFFQHEMRIEQEAIESLLELVENNTRALKTVCTQLSLFFEKGRRITAHDISSLLVHTKEETSFTLFDALSKRDLEHSLMILNTLLCSKDVAPVQILAGLLTRSVALRIGTIYRRTKRTLQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83607</accession>
    <name>Y598_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0598</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0598</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71303">
        <property type="entry name" value="H71303"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83607"/>
    <dbReference type="IntAct" id="O83607">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0598"/>
    <dbReference type="PRIDE" id="O83607"/>
    <dbReference type="EnsemblBacteria" id="AAC65581">
        <property type="protein sequence ID" value="AAC65581"/>
        <property type="gene ID" value="TP_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0598"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.637"/>
    <dbReference type="eggNOG" id="ENOG5034689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019092_1_0_12"/>
    <dbReference type="OMA" id="RISAWDY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202284" description="Uncharacterized protein TP_0598">
        <location>
            <begin position="1"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="605" mass="66846" checksum="F027857FD2F587D1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83613</accession>
    <name>RRF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">TP_0604</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71304">
        <property type="entry name" value="F71304"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882050.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83613"/>
    <dbReference type="SMR" id="O83613"/>
    <dbReference type="IntAct" id="O83613">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0604"/>
    <dbReference type="EnsemblBacteria" id="AAC65577">
        <property type="protein sequence ID" value="AAC65577"/>
        <property type="gene ID" value="TP_0604"/>
    </dbReference>
    <dbReference type="GeneID" id="57879127"/>
    <dbReference type="KEGG" id="tpa:TP_0604"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_12"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167570" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="183" mass="20504" checksum="AE16B5894DDD7C4B" modified="1998-11-01" version="1">MGIAECYEQKMKKSLSALQEGFNTLRTERATAHLLDQITVDYYQQPTALSQVATVSVPEARLIIIQPWDKTLLADIERAILKSKLSLNPSNDGKVIRLVIPPLTQERRKELVRQARALAEQARVAIRNIRREGIEEAKRGHKEGLLSEDALKAAEEAFQKATDASVADVARYLAEKEKDILEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83627</accession>
    <name>Y618_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0618</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0618</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To T.pallidum TP_0127, TP_0315 and TP_0619.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71301">
        <property type="entry name" value="C71301"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83627"/>
    <dbReference type="IntAct" id="O83627">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0618"/>
    <dbReference type="EnsemblBacteria" id="AAC65601">
        <property type="protein sequence ID" value="AAC65601"/>
        <property type="gene ID" value="TP_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0618"/>
    <dbReference type="HOGENOM" id="CLU_1947882_0_0_12"/>
    <dbReference type="OMA" id="CIEAPSW"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202289" description="Uncharacterized protein TP_0618">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="119" mass="12707" checksum="20F04AE9FA0C1235" modified="1998-11-01" version="1">MWRKCLGKVVLLGCALPCVAARISVSPKLGAYGDARGGPDLWGLCIKATDAEEVSGDPDDTEMEYLPPRYAPETPLVGLDVAFRAENGFLLQLTVDAALTRLMFRGQCLAGYSFRPGGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83640</accession>
    <name>SYW_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="1">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpS</name>
        <name type="synonym">trsA</name>
        <name type="ordered locus">TP_0632</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71300">
        <property type="entry name" value="F71300"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882078.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83640"/>
    <dbReference type="SMR" id="O83640"/>
    <dbReference type="IntAct" id="O83640">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0632"/>
    <dbReference type="EnsemblBacteria" id="AAC65607">
        <property type="protein sequence ID" value="AAC65607"/>
        <property type="gene ID" value="TP_0632"/>
    </dbReference>
    <dbReference type="GeneID" id="57879155"/>
    <dbReference type="KEGG" id="tpa:TP_0632"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_1_12"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136701" description="Tryptophan--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <sequence length="337" mass="37562" checksum="75CE7018C14A166D" modified="1998-11-01" version="1">MLRVLTGDRPTGRLHLGHYAGSLGTRLRIQSEHECFFIIADLHTLTTRHGRAQLAELPALVRELVLDYLACGIDAQRAVIYLQSAVPEVTELAFIFANLVTVPRLQRIPSLKEMAQAANLSELPFGLLGYPVLQAADILLARAHLVPVGKDNESHVELTREVAKRFNRLYGEVFPLPRALLSDCATLVGTDGQAKMSKSLGNAIFLSDDEETVRRKVRAMYTDPARTRADIPGRVEGNPVFAYHDAFNPNTDEVAHFKERYRAGRVGDTEVKDALARALNTFLEPIRARRAQLEQQPAYLARVLEEGCARMRAEARKTMQRVKEAMGLSARPLVHLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83645</accession>
    <name>Y638_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0638</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0638</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71298">
        <property type="entry name" value="E71298"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882083.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83645"/>
    <dbReference type="IntAct" id="O83645">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65625">
        <property type="protein sequence ID" value="AAC65625"/>
        <property type="gene ID" value="TP_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0638"/>
    <dbReference type="HOGENOM" id="CLU_150098_0_0_12"/>
    <dbReference type="OMA" id="NIFTSTM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202293" description="Uncharacterized protein TP_0638">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="144" mass="15394" checksum="7D93DA9921FC7699" modified="1998-11-01" version="1">MGTLRRFPASVLQIALALFLLASGARDLVHVDAGVFNAAVYFLGGLFRGHVAIGVLTLAVSLCCLTAGFFLLVDFLRPELSCVSAVLALFVVLWALNMVLVDVVGAFGRGKVLQNVSSALEHLHHTAVDLLVLGALIFVRQHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83655</accession>
    <name>O83655_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemolysin (TlyC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71299">
        <property type="entry name" value="H71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882094.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83655">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0649"/>
    <dbReference type="EnsemblBacteria" id="AAC65622">
        <property type="protein sequence ID" value="AAC65622"/>
        <property type="gene ID" value="TP_0649"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75829">
        <property type="protein sequence ID" value="AGN75829"/>
        <property type="gene ID" value="TPANIC_0649"/>
    </dbReference>
    <dbReference type="GeneID" id="57879173"/>
    <dbReference type="KEGG" id="tpa:TP_0649"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.642"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_3_0_12"/>
    <dbReference type="OMA" id="QMISIKA"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="265" mass="30399" checksum="E41B63F919228864" modified="1998-11-01" version="1">MGVIDWLRRRHAVTHIFQQPLNEEKQDMIRGIVDLSDTSVREVMIPRIDVDFLELSMSGETLVEKVTESGHSRFPVYEQTIDNVVGVLYVKDLIKLFGRPQEVRLERLLRKPFFVPESKRIDSLLREFKRRHVHIAIAVDEYGGVSGIACMEDIIEEIVGDIQDEFDHEREDIEPLGQGVWLCDARVDLEDLSECLHTVFPSQEFGTLGGFVFNLFGKIPVKYEKVSWGAFDFIIQDMEAHKINTIKIVSVLRGDSEPACVSERP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83659</accession>
    <name>O83659_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine ABC transporter, permease protein (PotB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71296">
        <property type="entry name" value="F71296"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882098.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83659">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0653"/>
    <dbReference type="EnsemblBacteria" id="AAC65628">
        <property type="protein sequence ID" value="AAC65628"/>
        <property type="gene ID" value="TP_0653"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75832">
        <property type="protein sequence ID" value="AGN75832"/>
        <property type="gene ID" value="TPANIC_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0653"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.646"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_3_12"/>
    <dbReference type="OMA" id="RIYAWMI"/>
    <dbReference type="OrthoDB" id="1488093at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="299" mass="32473" checksum="46A0E8463B4A5A98" modified="1998-11-01" version="1">MSSRLRVARRRTVGSLGFWCTLPLSAWLTVFFLCPLTVVAVYSFLQKGLYGGVVWKFSIRAYAQVLTSGYGALLARTLLISTGVTCLCVLLALPAGYALSRSRRQTFFLFLIIVPFWTNSLIRINAWITILGNQGFLNEALKSLGFITRSLPLLYHNGAVIVVLTYMFLPYAIFPIFAAIDRFDFSLLESACDLGSTPTGAIIRVLLPNIKTGIATAVFFTFIPVFGSYTVPLLVGGKDSYLIGNAIVDQVRIVGNWPLASAFAMLVTLAGGVGVLWILAESGACNTTPPPCGGRRSYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>O83697</accession>
    <name>Y699_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0699</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0699</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71293">
        <property type="entry name" value="H71293"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83697"/>
    <dbReference type="SMR" id="O83697"/>
    <dbReference type="IntAct" id="O83697">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65668">
        <property type="protein sequence ID" value="AAC65668"/>
        <property type="gene ID" value="TP_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0699"/>
    <dbReference type="HOGENOM" id="CLU_3359083_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202305" description="Uncharacterized protein TP_0699">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <sequence length="36" mass="4089" checksum="154D6038B515280E" modified="1998-11-01" version="1">MQAEVLDFFEDRGETPPGRSSEAGYGLFWRVGVVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83702</accession>
    <name>O83702_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71289">
        <property type="entry name" value="D71289"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882149.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83702">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0704"/>
    <dbReference type="EnsemblBacteria" id="AAC65672">
        <property type="protein sequence ID" value="AAC65672"/>
        <property type="gene ID" value="TP_0704"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75879">
        <property type="protein sequence ID" value="AGN75879"/>
        <property type="gene ID" value="TPANIC_0704"/>
    </dbReference>
    <dbReference type="GeneID" id="57879229"/>
    <dbReference type="KEGG" id="tpa:TP_0704"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.694"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_12"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="78"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="454"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="594"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="706" mass="78762" checksum="7E22BAAA16827BC1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83717</accession>
    <name>O83717_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase (GltA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71288">
        <property type="entry name" value="D71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882180.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83717">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0735"/>
    <dbReference type="EnsemblBacteria" id="AAC65703">
        <property type="protein sequence ID" value="AAC65703"/>
        <property type="gene ID" value="TP_0735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75909">
        <property type="protein sequence ID" value="AGN75909"/>
        <property type="gene ID" value="TPANIC_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0735"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.724"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_12"/>
    <dbReference type="OMA" id="QETQCEQ"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="518" mass="55951" checksum="687009CC27AA89AF" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83718</accession>
    <name>O83718_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase, gamma chain (HydG)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71288">
        <property type="entry name" value="E71288"/>
    </dbReference>
    <dbReference type="IntAct" id="O83718">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0736"/>
    <dbReference type="EnsemblBacteria" id="AAC65704">
        <property type="protein sequence ID" value="AAC65704"/>
        <property type="gene ID" value="TP_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0736"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_0_12"/>
    <dbReference type="OMA" id="AGQFIIL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="280" mass="30544" checksum="F9FE12A26F1A7DDD" modified="1998-11-01" version="1">MFSILEKKQFSPQVFYLKVHAPDIAKNRAAGQFVLVQLDDEYAERIPLTIADAHADEGWIALVIQTVGATTMRLCEKEVGDSISVVLGPLGNPTLIENVGTVACVAGGVGAAPLYPIAQAHKRAGNHVIVILGARNRDLIIFEEEMRALADELVIVTDDGSYGRKGLVTEPLRELCXRASCPQEVVAIGPPIMMKFCAETTRPFGIRTVVSLNTIMIDGTGMCGGCRVNVGSEIKFVCVDGPEFDGHQVDFESMMRRMRAFQAREAHDVHCCKMKHHAGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83727</accession>
    <name>RL21_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">TP_0745</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71286">
        <property type="entry name" value="F71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882190.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83727"/>
    <dbReference type="SMR" id="O83727"/>
    <dbReference type="STRING" id="243276.TPANIC_0745"/>
    <dbReference type="EnsemblBacteria" id="AAC65713">
        <property type="protein sequence ID" value="AAC65713"/>
        <property type="gene ID" value="TP_0745"/>
    </dbReference>
    <dbReference type="GeneID" id="57879269"/>
    <dbReference type="KEGG" id="tpa:TP_0745"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_3_12"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000181019" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="105" mass="11816" checksum="841938DD82627DC3" modified="1998-11-01" version="1">MYALIEYKGKQYKVERGSSIVVDNISEVAPGGCIDVREVLMIGGEGLTRIGSPYLEGVGVRAVVGECFRSRKITVYKYKSKKDYHRTIGHRQWYTRLTVSDILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83769</accession>
    <name>O83769_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Antibiotic transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71280">
        <property type="entry name" value="E71280"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882235.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83769">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0790"/>
    <dbReference type="EnsemblBacteria" id="AAC65756">
        <property type="protein sequence ID" value="AAC65756"/>
        <property type="gene ID" value="TP_0790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75962">
        <property type="protein sequence ID" value="AGN75962"/>
        <property type="gene ID" value="TPANIC_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0790"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.836"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008861_1_1_12"/>
    <dbReference type="OMA" id="AFKIYYV"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="266"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="755"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="888" mass="97519" checksum="BDF5496DB7A5ADE6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83813</accession>
    <name>O83813_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic serine protease DO (HtrA-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71275">
        <property type="entry name" value="F71275"/>
    </dbReference>
    <dbReference type="IntAct" id="O83813">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0841"/>
    <dbReference type="MEROPS" id="S01.525"/>
    <dbReference type="EnsemblBacteria" id="AAC65807">
        <property type="protein sequence ID" value="AAC65807"/>
        <property type="gene ID" value="TP_0841"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76011">
        <property type="protein sequence ID" value="AGN76011"/>
        <property type="gene ID" value="TPANIC_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0841"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.828"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_12"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="279"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="485" mass="51678" checksum="45923AC2E453D52D" modified="1998-11-01" version="1">MPSADTIARRVAGDSGNAGGRTLLPVGVSRESVQLLERLQNANRQVTAEVLPSVVTLDVVETRKVRVRDPFGGFPWFFFRGPEGPGAGPGGGSGNKGEAEEREYKTEGLGSGVIVKKTGKTHYVLTNYHVAGKANEIEIKLHDGRIVKGKLVGGDQRKDIALVSFEDADPNIRVAVLGDSDAVRVGDIVFAVGSPLGYTSTVTQGIISALGRFGGPGNNINDFIQTDAAINQGNSGGPMVNIYGEVIGINAWIASSSGGSQGIGFSIPINNVKSDIESFIQYGQVKYGWLGVQLVATDADTVASLGIAKGTKGVLAAEIFLGSPAHKGGLKPGDYCVKLNGKEVKDVNQFVRDVGALRIGQTAVFDLIRGGVPMTLSVRITERDEKIVNDYSKLWPGFIPLPLTEAVRKRLDLKASVRGVLVSNAQSKSPAALMGLKSADIVVAVNDQRVSSVREFYAVLARQTREVWFDVLRDGQTLSTVRFRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83814</accession>
    <name>MAP1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine aminopeptidase</fullName>
            <shortName evidence="1">MAP</shortName>
            <shortName evidence="1">MetAP</shortName>
            <ecNumber evidence="1">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">map</name>
        <name type="ordered locus">TP_0842</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71273">
        <property type="entry name" value="B71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882286.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83814"/>
    <dbReference type="SMR" id="O83814"/>
    <dbReference type="IntAct" id="O83814">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0842"/>
    <dbReference type="EnsemblBacteria" id="AAC65810">
        <property type="protein sequence ID" value="AAC65810"/>
        <property type="gene ID" value="TP_0842"/>
    </dbReference>
    <dbReference type="GeneID" id="57879359"/>
    <dbReference type="KEGG" id="tpa:TP_0842"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_12"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148966" description="Methionine aminopeptidase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <sequence length="255" mass="27316" checksum="4EDE582C67F3526A" modified="1998-11-01" version="1">MIRIKTPEQIDGIRASCKALARLFDVLIPLVKPGVQTQELDAFCQRFIRSVGGVPAWFSEGFPAAACISINEEVIHGLPSARVIQDGDLVSLDVGINLNGYISDACRTVPVGGVAHERLELLRVTTECLRAGIKACRAGARVRAVSRAVYAVAARHRFGVVYEYCGHGVGLAVHEEPNIPNVPGLEGPNPRFLPGMVVAIEPMLTLGTDEVRTSADGWTVVTADGSCACHVEHTVAVFADHTEVLTEPTEVERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83846</accession>
    <name>O83846_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TsaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71271">
        <property type="entry name" value="B71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882319.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83846">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0876"/>
    <dbReference type="EnsemblBacteria" id="AAC65839">
        <property type="protein sequence ID" value="AAC65839"/>
        <property type="gene ID" value="TP_0876"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76045">
        <property type="protein sequence ID" value="AGN76045"/>
        <property type="gene ID" value="TPANIC_0876"/>
    </dbReference>
    <dbReference type="GeneID" id="57879390"/>
    <dbReference type="KEGG" id="tpa:TP_0876"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.860"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_12"/>
    <dbReference type="OMA" id="GPVYIRK"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="221" mass="23647" checksum="103E3CA7B6B80286" modified="1998-11-01" version="1">MNILAINTVAHALNVAAEGAQGTAVVSIEGAHCCIQQQLVRALDVVVKRAGFPVQETQIVACPRGPGSFTGLRTGFAVAKALQLGVGARFIAVPTLRLAAHPFRAFTGRVLSILDAKRGRFFWNCFKSGEPLFEDSHNHAQEIVKKVDTRVPCLVCGTGTALFKSVMESQDNTVPFMYVETDAHEGAKTLLALVKVLNHSAATPGERGAPQYTTRTYAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O83851</accession>
    <name>O83851_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein (NatA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71271">
        <property type="entry name" value="G71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882324.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83851">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0881"/>
    <dbReference type="EnsemblBacteria" id="AAC65843">
        <property type="protein sequence ID" value="AAC65843"/>
        <property type="gene ID" value="TP_0881"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76050">
        <property type="protein sequence ID" value="AGN76050"/>
        <property type="gene ID" value="TPANIC_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="57879395"/>
    <dbReference type="KEGG" id="tpa:TP_0881"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.865"/>
    <dbReference type="eggNOG" id="COG4555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30045" checksum="ED34E58798807468" modified="1998-11-01" version="1">MEVLRVTSLTKHYGSRRHPVRGCEDVTFCVERGQVCGILGLNGAGKSTVLRVIGGLIHPSSGEVYACHCSLSRYPVGYRRHIGVLHEQNPLYADMTVEQHILFVARIFQLADGEARTAEMIELFQLQSVAHRRVRNLSKGYKQRVGLAQALVHRPKLLVLDEPLSGLDIVYLKEFHKEIVAQNNNLAVVFSTHAVQEIEALCDVFVLLHAGHVLFSGNRAQIAARIVREFPEKKQTVALHLETGTFIAFVFEQYMQWQSAQDAACYAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83857</accession>
    <name>RS15_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">TP_0887</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71269">
        <property type="entry name" value="D71269"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882330.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83857"/>
    <dbReference type="SMR" id="O83857"/>
    <dbReference type="STRING" id="243276.TPANIC_0887"/>
    <dbReference type="EnsemblBacteria" id="AAC26577">
        <property type="protein sequence ID" value="AAC26577"/>
        <property type="gene ID" value="TP_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="57879401"/>
    <dbReference type="KEGG" id="tpa:TP_0887"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_12"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000115577" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="89" mass="10056" checksum="478CD7A8096BD5B7" modified="1998-11-01" version="1">MALTKERTASVVQQYGSGEKDTGSSSVQIALLTERIRQLTDHCKVHPKDKSSNRGLLVLVGRRRRLLRYSRRVSMGAYRSLVKSLGLRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83870</accession>
    <name>Y900_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0900</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0900</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71267">
        <property type="entry name" value="A71267"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83870"/>
    <dbReference type="STRING" id="243276.TPANIC_0899"/>
    <dbReference type="EnsemblBacteria" id="AAC65868">
        <property type="protein sequence ID" value="AAC65868"/>
        <property type="gene ID" value="TP_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0900"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012127_0_0_12"/>
    <dbReference type="OMA" id="WEVWIEA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202347" description="Uncharacterized protein TP_0900">
        <location>
            <begin position="1"/>
            <end position="797"/>
        </location>
    </feature>
    <sequence length="797" mass="89504" checksum="DEBE3440CB6D7999" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83878</accession>
    <name>TRMD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber>2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">trmD</name>
        <name type="ordered locus">TP_0908</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71268">
        <property type="entry name" value="A71268"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882351.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83878"/>
    <dbReference type="SMR" id="O83878"/>
    <dbReference type="STRING" id="243276.TPANIC_0908"/>
    <dbReference type="PRIDE" id="O83878"/>
    <dbReference type="EnsemblBacteria" id="AAC65860">
        <property type="protein sequence ID" value="AAC65860"/>
        <property type="gene ID" value="TP_0908"/>
    </dbReference>
    <dbReference type="GeneID" id="57879418"/>
    <dbReference type="KEGG" id="tpa:TP_0908"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_12"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060488" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="250" mass="28119" checksum="02425EEC28BC12A3" modified="1998-11-01" version="1">MNIDVLTLFPAIPRVYFSTSIMARAVSDGIIHYNIVNIRDFAHDKHKHCDAPPYGGGPGMLMRSEPLGKALDSVDAPKKRVVYVTPSGKLFEQGYARSLAQERALVLICGRYEGIDQRIIDEYVDDEVCIGNYVLSSGEIAALVLIDAVSRCVSGVIRHESLEEESFVNSLVEYPQYTRPRCFHNRDVPPVLLSGHHAHIRTWRLARQIEKTRRNRPDLLSAARASAAWTQEAESLLKELDYELPPHPTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83879</accession>
    <name>RL19_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rplS</name>
        <name type="ordered locus">TP_0909</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71268">
        <property type="entry name" value="B71268"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882352.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83879"/>
    <dbReference type="SMR" id="O83879"/>
    <dbReference type="IntAct" id="O83879">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0909"/>
    <dbReference type="EnsemblBacteria" id="AAC65861">
        <property type="protein sequence ID" value="AAC65861"/>
        <property type="gene ID" value="TP_0909"/>
    </dbReference>
    <dbReference type="GeneID" id="57879419"/>
    <dbReference type="KEGG" id="tpa:TP_0909"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_12"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000163561" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="123" mass="14192" checksum="123E652CB4B545EF" modified="1998-11-01" version="1">MSCHLIQQIENQQRKEPAETFRVGDTVRVHFKIVEGKTERIQAYEGLVLCFKNSGVRRTFTVRKNSYGVGVERIFPLHSPRIERVDVVRAGKVRRAKLYYIREKIGKAARIKARIVKKPSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83884</accession>
    <name>O83884_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71264">
        <property type="entry name" value="G71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882357.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83884">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0914"/>
    <dbReference type="EnsemblBacteria" id="AAC65871">
        <property type="protein sequence ID" value="AAC65871"/>
        <property type="gene ID" value="TP_0914"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76082">
        <property type="protein sequence ID" value="AGN76082"/>
        <property type="gene ID" value="TPANIC_0914"/>
    </dbReference>
    <dbReference type="GeneID" id="57879425"/>
    <dbReference type="KEGG" id="tpa:TP_0914"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.898"/>
    <dbReference type="eggNOG" id="ENOG50339QT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128613_1_0_12"/>
    <dbReference type="OMA" id="EEICYLG"/>
    <dbReference type="OrthoDB" id="2035956at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14573" checksum="44A56360C0904ACF" modified="1998-11-01" version="1">MTDVQSSGRRRKRKRTPRRDVFSPKLEFCEYVCPRCKEVIKDLPVALGDKDSGRPVHFDCVLSFLRESECLAAHEHVVYVGQGKFAVIVFPNPASTTCFSIVRLIEWETKNTLLEWRAGVAKICSQVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83892</accession>
    <name>Y922_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0922</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0922</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71265">
        <property type="entry name" value="G71265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65879">
        <property type="protein sequence ID" value="AAC65879"/>
        <property type="gene ID" value="TP_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0922"/>
    <dbReference type="HOGENOM" id="CLU_936707_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202351" description="Uncharacterized protein TP_0922">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="297" mass="32898" checksum="925349B09560BCFD" modified="1998-11-01" version="1">MPPSPCAVLRVRHTKPARAAGVAAHRSFSLCNEAVYRRGQKVFPLVLRRAARFLHECLPARCEVFEHARSEAKKVHRRYFLPGECAGRACRVWRAVFRALXGNDPSAAVRVPADVRVFVYGTHQASCGGDCGGGGRDCGVSVRKGADTARNATGFAERVHKGVADHGVACRVQPLRGKVRGKRFVRVASVVVISVDNRKRCSQLCACAQQRVRRPPRRAPRRMRQSGAVCPCFLCREGLKHVLRIAVLREVVKQARAKVALYIMPNNTQHAGKPGAQHRTRRSPPAFRRADRLRQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83906</accession>
    <name>O83906_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hemolysin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71262">
        <property type="entry name" value="D71262"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882379.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83906">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0936"/>
    <dbReference type="EnsemblBacteria" id="AAC65893">
        <property type="protein sequence ID" value="AAC65893"/>
        <property type="gene ID" value="TP_0936"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76101">
        <property type="protein sequence ID" value="AGN76101"/>
        <property type="gene ID" value="TPANIC_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0936"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.918"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_776004_0_0_12"/>
    <dbReference type="OMA" id="SREQNEQ"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="357" mass="40514" checksum="9DA9664197261692" modified="1998-11-01" version="1">MEKCESQPYEIFITIGFVGQRMKWDWAANIFSLLMGKSWQRQRARASMLQMSYADCAVCFDQGIGSYMVHRTDIVWVEARALPSHIFSMISQHDDYNYFPVCARTIDAVVGYFSVQRYVRVCLEMERSAGASREQDEQESVASALHVHMEGRRHAHAKGQGVWIADPVIARIVQQPIFVPEVISVRKLLHLFQQMQAQMAFVIDEYGGIEGMVTRDELIMRCVQEYARADGINSEDCFQNPDGSWIVSGWMNLNEMYRLGVLARTTRPHTGVHTIAGYVLSIRNRIPRVKEQLNANGCRFTILKMDGRRIDRLLVEREHPVPSTSGEVPSKGGGKETGDPLSSPRFAKNRKNGPGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83914</accession>
    <name>O83914_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71263">
        <property type="entry name" value="D71263"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882387.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83914">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0944"/>
    <dbReference type="EnsemblBacteria" id="AAC65897">
        <property type="protein sequence ID" value="AAC65897"/>
        <property type="gene ID" value="TP_0944"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76108">
        <property type="protein sequence ID" value="AGN76108"/>
        <property type="gene ID" value="TPANIC_0944"/>
    </dbReference>
    <dbReference type="GeneID" id="57879454"/>
    <dbReference type="KEGG" id="tpa:TP_0944"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.927"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064306_0_0_12"/>
    <dbReference type="OMA" id="IQIWLKM"/>
    <dbReference type="OrthoDB" id="1290611at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="390" mass="43479" checksum="5306F1EBB0C89007" modified="1998-11-01" version="1">MALSVLDRAKRKFAQEKYGEVIKLLEPCVLDYHESFVFHLYLGLACLHEGIVTGAVSYLGRARQIKMSHPTLLCAEAALALKRRDTNRAVERYIAVLDADPKHRLAQKGLNALKAHHTPESLAGFIQSGKVKALYPRPGVAEYRRRSVVCAVGVGCLCTLLVGALGIAGLRVWHSGLWRGTARTSRADVSFLTLTKEEYARPLEGSGSYRYTLSKQDVLQSYANAQKYFQTFKDNAAQVEINKLLASNASHSIKRRARMLMDYFALPTFDTFPDEDNYPYVQVREQKGLYLDCWVVWQGMAANVKRTERSVSFNLLVGYDRLTKLEGIVPVFCNFVVSVDPQKPIRVLGKVQMRGDILYLKARSVFQSVHSQSGTVSGDRQGAAAVLKAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83917</accession>
    <name>RL34_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpmH</name>
        <name type="ordered locus">TP_0951</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71261">
        <property type="entry name" value="E71261"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882395.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83917"/>
    <dbReference type="SMR" id="O83917"/>
    <dbReference type="STRING" id="243276.TPANIC_0951"/>
    <dbReference type="EnsemblBacteria" id="AAC65910">
        <property type="protein sequence ID" value="AAC65910"/>
        <property type="gene ID" value="TP_0951"/>
    </dbReference>
    <dbReference type="GeneID" id="57879597"/>
    <dbReference type="KEGG" id="tpa:TP_0951"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_12"/>
    <dbReference type="OMA" id="RMASVNG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000187496" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="51" mass="6235" checksum="5F1119B108C8B830" modified="1998-11-01" version="1">MKRTYQPSRRKRVRKFGFRARMATRGGRAILRRRRAKGRRKLTVSDEKKPY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83922</accession>
    <name>Y956_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0956</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0956</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71258">
        <property type="entry name" value="G71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882400.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="3U64">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A=23-323"/>
    </dbReference>
    <dbReference type="PDB" id="4DI3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.05 A"/>
        <property type="chains" value="A/B/C=23-323"/>
    </dbReference>
    <dbReference type="PDB" id="4DI4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.71 A"/>
        <property type="chains" value="A=23-323"/>
    </dbReference>
    <dbReference type="PDBsum" id="3U64"/>
    <dbReference type="PDBsum" id="4DI3"/>
    <dbReference type="PDBsum" id="4DI4"/>
    <dbReference type="AlphaFoldDB" id="O83922"/>
    <dbReference type="SMR" id="O83922"/>
    <dbReference type="IntAct" id="O83922">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0956"/>
    <dbReference type="EnsemblBacteria" id="AAC65922">
        <property type="protein sequence ID" value="AAC65922"/>
        <property type="gene ID" value="TP_0956"/>
    </dbReference>
    <dbReference type="GeneID" id="57879466"/>
    <dbReference type="KEGG" id="tpa:TP_0956"/>
    <dbReference type="eggNOG" id="ENOG5032WII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074357_0_0_12"/>
    <dbReference type="OMA" id="WTASAWT"/>
    <dbReference type="OrthoDB" id="1646140at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031823">
        <property type="entry name" value="TatT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038537">
        <property type="entry name" value="TatT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16811">
        <property type="entry name" value="TAtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202363" description="Uncharacterized protein TP_0956">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="107"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="150"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="turn" evidence="1">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="262"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="turn" evidence="1">
        <location>
            <begin position="271"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="helix" evidence="1">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0007829" key="1">
        <source>
            <dbReference type="PDB" id="3U64"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="4DI3"/>
        </source>
    </evidence>
    <sequence length="323" mass="36005" checksum="FB48CDD9542FBCA3" modified="1998-11-01" version="1">MKHPSVRVCCFAFASCLLCAGCSLKRLAFSSLSHTLAPFPEGELDAHLSDADFTRVFTEEDDLDLVAQSLPLVLKVYEALHLQNPAHRGLSLAVGRLYIMYANAFVQTPAQYLPEDEFEAQNEAYSRARKLYLRGARYALSSLETAYPGFTREVFSGDEQRLHKVLSRCTRVDVGTLYWVGTGYVAAFALTPLGSALPDTVHAAVMMLERACDLWPSYQEGAVWNVLTKFYAAAPESFGGGMEKAHTAFEHLTRYCSAHDPDHHITYADALCIPLNNRAGFDEALDRALAIDPESVPHNKLLVILSQKRARWLKAHVQDFFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83929</accession>
    <name>O83929_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71259">
        <property type="entry name" value="F71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882407.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83929">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0963"/>
    <dbReference type="EnsemblBacteria" id="AAC65918">
        <property type="protein sequence ID" value="AAC65918"/>
        <property type="gene ID" value="TP_0963"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76128">
        <property type="protein sequence ID" value="AGN76128"/>
        <property type="gene ID" value="TPANIC_0963"/>
    </dbReference>
    <dbReference type="GeneID" id="57879473"/>
    <dbReference type="KEGG" id="tpa:TP_0963"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.947"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_12"/>
    <dbReference type="OMA" id="GIMNITF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="309"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="409" mass="43579" checksum="F5111F616C1F305F" modified="1998-11-01" version="1">MVGEDFLYALHTFNARRGRTVLSLLGIVVGITSVVVVATLGSSLGASVEKLFEEDNNNIISVAPVAAHDDGVPRGQLVLTEHVRHHLKERVAGVQGFFYLNYLQASASRRSLHAGAVSVLGVEHGWLAASGLTVSYGSDVSVIGYAVGTHSVILGKQTAEGLFPEGNAVGKTITLYVPIGRNKVLPMVVRVAAVLKEKDDFSFSSAAQVLIPRSVLTREFSRRIADAMDLKVYDSGSIAHVEDKVKSVLTNLTGNEKAFEVSSLHLIVEQMRSFLRAMNMVLTGIAAISLIVGGIGIMNIMLVTVAERRQEIGLRKALGASRMHVLHQFLVESATLTFVGGLCGVVLGLLLSVIVIAGLNAFDFQMTFSPSVVGMFIAFAGSVVIGVCFGSYPAFQAAGLDPIQSLEDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83939</accession>
    <name>Y974_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0974</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0974</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71257">
        <property type="entry name" value="D71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882418.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83939"/>
    <dbReference type="SMR" id="O83939"/>
    <dbReference type="IntAct" id="O83939">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0974"/>
    <dbReference type="EnsemblBacteria" id="AAC65939">
        <property type="protein sequence ID" value="AAC65939"/>
        <property type="gene ID" value="TP_0974"/>
    </dbReference>
    <dbReference type="GeneID" id="57879483"/>
    <dbReference type="KEGG" id="tpa:TP_0974"/>
    <dbReference type="eggNOG" id="ENOG502ZRHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184596_0_0_12"/>
    <dbReference type="OMA" id="DPSYIND"/>
    <dbReference type="OrthoDB" id="1846356at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202367" description="Uncharacterized protein TP_0974">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <sequence length="93" mass="10222" checksum="0682BB629B63DA09" modified="1998-11-01" version="1">MMIDKLSGLDPVQNLRASCASEHVARAPAGDEITVSAEAQKKAELYLALEAVRSAPDVREYKIAAAEQKLADPAYLERALSHVVERFLEEQNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83948</accession>
    <name>Y983_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0983</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0983</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71258">
        <property type="entry name" value="E71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882427.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83948"/>
    <dbReference type="IntAct" id="O83948">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0983"/>
    <dbReference type="EnsemblBacteria" id="AAC65941">
        <property type="protein sequence ID" value="AAC65941"/>
        <property type="gene ID" value="TP_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0983"/>
    <dbReference type="eggNOG" id="ENOG50343I0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104224_0_0_12"/>
    <dbReference type="OMA" id="PWGDPGL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014270" description="Uncharacterized protein TP_0983">
        <location>
            <begin position="29"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="238" mass="27194" checksum="C5CAF2C9E6921856" modified="1998-11-01" version="1" precursor="true">MSRNSRGSGRYVFVVLACVFGYTRAVHAEVYTDPSTSGHVTISIPIWAFVEPQPGVMTQQAESPRTPPPQTLRELGAFVLGGAVYGWRFSYTPKEKKRAVMEHFTLTPIFPLPPDSPQISLRHVRTPYPYIHCRAEYSLDARHATHMRQSRNLTYQRAQGRGRGERKEELKGVYHAYHRAIVDALRKTVRKTQKNKPKEVEGMLYVKDNPRLFVEAGEFVAELSLSVHFTKITPYSVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83968</accession>
    <name>Y1003_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1003</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1003</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71254">
        <property type="entry name" value="E71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882447.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83968"/>
    <dbReference type="IntAct" id="O83968">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1003"/>
    <dbReference type="EnsemblBacteria" id="AAC65959">
        <property type="protein sequence ID" value="AAC65959"/>
        <property type="gene ID" value="TP_1003"/>
    </dbReference>
    <dbReference type="GeneID" id="57879514"/>
    <dbReference type="KEGG" id="tpa:TP_1003"/>
    <dbReference type="HOGENOM" id="CLU_803954_0_0_12"/>
    <dbReference type="OMA" id="NIYLLWT"/>
    <dbReference type="OrthoDB" id="1411290at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202372" description="Uncharacterized protein TP_1003">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="345" mass="37828" checksum="8745F06B874BA070" modified="1998-11-01" version="1">MTIAGRNKVVAFSIVLSALLCSISLLQAAFVLSGGSLPQLAVARVPPLLHTTGRAFMHVLTFLLPEAAARSLAAVSTAPSNSSTLVAILGTGLSAPLLLTYLLRRFEKTHAVEISYFSLFLCALNFEGVRLFLPILYTGTLTTYAGNVPMQIVMFFRSLALLALFASGIFAKKTLTRQEGAVVFVLCTVAFLISRYTTIHTIHAYRPSQSTQGAILLAQPISESGSIIDSTGEEKTLKVRSSAHRKTRILVTPQRNFTFYYGSHAWHRWFFWTTAVLSALSYGVLGHTLQISHYYIAAAALPFVIAGYRLLTHGLTWSACIVGLFLLNTASVFFIRSVHRVHIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="140" xmlns="http://uniprot.org/uniprot">
    <accession>O83970</accession>
    <name>O83970_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaX</name>
        <name evidence="3" type="ordered locus">TP_1005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582351">
            <id>O83970</id>
        </interactant>
        <interactant intactId="EBI-1582320">
            <id>O83097</id>
            <label>dnaB</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1582351">
            <id>O83970</id>
        </interactant>
        <interactant intactId="EBI-1585371">
            <id>O83107</id>
            <label>rlmN</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71254">
        <property type="entry name" value="G71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882449.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83970">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1005"/>
    <dbReference type="EnsemblBacteria" id="AAC65953">
        <property type="protein sequence ID" value="AAC65953"/>
        <property type="gene ID" value="TP_1005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76169">
        <property type="protein sequence ID" value="AGN76169"/>
        <property type="gene ID" value="TPANIC_1005"/>
    </dbReference>
    <dbReference type="GeneID" id="57879516"/>
    <dbReference type="KEGG" id="tpa:TP_1005"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.991"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_4_12"/>
    <dbReference type="OMA" id="KKIAHAY"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="572" mass="62486" checksum="A0A8B340FACD3B67" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O84000</accession>
    <name>Y1037_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0073 membrane protein TP_1037</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1037</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71250">
        <property type="entry name" value="D71250"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O84000"/>
    <dbReference type="SMR" id="O84000"/>
    <dbReference type="IntAct" id="O84000">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1037"/>
    <dbReference type="EnsemblBacteria" id="AAC26591">
        <property type="protein sequence ID" value="AAC26591"/>
        <property type="gene ID" value="TP_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1037"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_1_0_12"/>
    <dbReference type="OMA" id="HEVFHSL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000176904" description="UPF0073 membrane protein TP_1037">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="238" mass="26095" checksum="B74F7EB6CAFBECB1" modified="1998-11-01" version="1">MEKIVNADGSDAICPASAACAKSIRSYQESYSLGEEIANAVTHGIGVGLSIVALVLLVVRAVHYTPADLTARYVVGFSVFGSSLIVLYLCSTLYHALPRGAKYVFGVIDHCCIYVLIAGTYTASCLTTLYGAIGWTVFGVIWGLACSGSVIYSVFGHRVRWLSLVMYIAMGWLVVFVAKPLRERLPEISFLFLVLGGVLYTVGCVFYALKRIKWTHTIWHMFVIGGSVMHFFSLYLSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-05-25" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>P16665</accession>
    <name>TPF1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Antigen TpF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Antigen 4D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Antigen C1-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tpf1</name>
        <name type="ordered locus">TP_1038</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Microb. Pathog." volume="6" first="29" last="42">
            <title>Treponema pallidum subspecies pallidum (Nichols) and Treponema pallidum subspecies pertenue (CDC 2575) differ in at least one nucleotide: comparison of two homologous antigens.</title>
            <authorList>
                <person name="Noordhoek G.T."/>
                <person name="Hermans P.W.M."/>
                <person name="Paul A.N."/>
                <person name="Schouls L.M."/>
                <person name="van der Sluis J.J."/>
                <person name="van Embden J.D.A."/>
            </authorList>
            <dbReference type="PubMed" id="2471912"/>
            <dbReference type="DOI" id="10.1016/0882-4010(89)90005-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PROTEIN SEQUENCE OF 2-12</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="633" last="635">
            <title>Primary structure of an oligomeric antigen of Treponema pallidum.</title>
            <authorList>
                <person name="Walfield A.M."/>
                <person name="Roche E.S."/>
                <person name="Zounes M.C."/>
                <person name="Kirkpatrick H."/>
                <person name="Wild M.A."/>
                <person name="Textor G."/>
                <person name="Tsai P.K."/>
                <person name="Richardson C."/>
            </authorList>
            <dbReference type="PubMed" id="2643579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1987" name="J. Bacteriol." volume="169" first="1365" last="1371">
            <title>Role of disulfide bonds in the oligomeric structure and protease resistance of recombinant and native Treponema pallidum surface antigen 4D.</title>
            <authorList>
                <person name="Radolf J.D."/>
                <person name="Borenstein L.A."/>
                <person name="Kim J.Y."/>
                <person name="Fehniger T.E."/>
                <person name="Lovett M.A."/>
            </authorList>
            <dbReference type="PubMed" id="3549683"/>
        </citation>
        <scope>DISULFIDE BONDS</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>May play an important structural role in the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text>Homodecamer; either linked or stabilized by disulfide bonds.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="M32401">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JS0097">
        <property type="entry name" value="JS0097"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882482.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="2FJC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=22-177"/>
    </dbReference>
    <dbReference type="PDBsum" id="2FJC"/>
    <dbReference type="AlphaFoldDB" id="P16665"/>
    <dbReference type="SMR" id="P16665"/>
    <dbReference type="IntAct" id="P16665">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1038"/>
    <dbReference type="EnsemblBacteria" id="AAC26592">
        <property type="protein sequence ID" value="AAC26592"/>
        <property type="gene ID" value="TP_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1038"/>
    <dbReference type="eggNOG" id="COG0783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_2_2_12"/>
    <dbReference type="OMA" id="KKYHWDV"/>
    <dbReference type="OrthoDB" id="1742631at2"/>
    <dbReference type="EvolutionaryTrace" id="P16665"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00819">
        <property type="entry name" value="DPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000201664" description="Antigen TpF1">
        <location>
            <begin position="2"/>
            <end position="177"/>
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    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="29"/>
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    <feature type="strand" evidence="3">
        <location>
            <begin position="60"/>
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    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="65"/>
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    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="101"/>
            <end position="107"/>
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    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="117"/>
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    <feature type="helix" evidence="3">
        <location>
            <begin position="120"/>
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    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="2471912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2FJC"/>
        </source>
    </evidence>
    <sequence length="177" mass="19361" checksum="A0E0855069566773" modified="2007-01-23" version="2">MNMCTDGKKYHSTATSAAVGASAPGVPDARAIAAICEQLRQHVADLGVLYIKLHNYHWHIYGIEFKQVHELLEEYYVSVTEAFDTIAERLLQLGAQAPASMAEYLALSGIAEETEKEITIVSALARVKRDFEYLSTRFSQTQVLAAESGDAVTDGIITDILRTLGKAIWMLGATLKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>P29724</accession>
    <accession>O83339</accession>
    <name>TMPC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Membrane lipoprotein TmpC</fullName>
            <shortName>Membrane protein C</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>35 kDa antigen</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Lipoprotein TpN35</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Purine nucleoside receptor A</fullName>
            <shortName>PnrA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tmpC</name>
        <name type="ordered locus">TP_0319</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Infect. Immun." volume="59" first="3536" last="3546">
            <title>Characterization of the 35-kilodalton Treponema pallidum subsp. pallidum recombinant lipoprotein TmpC and antibody response to lipidated and nonlipidated T. pallidum antigens.</title>
            <authorList>
                <person name="Schouls L.M."/>
                <person name="van der Heide H.G.J."/>
                <person name="van Embden J.D.A."/>
            </authorList>
            <dbReference type="PubMed" id="1894360"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>MUTAGENESIS OF CYS-21</scope>
        <scope>DIACYLGLYCEROL AT CYS-21</scope>
        <scope>PALMITOYLATION AT CYS-21</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="J. Biol. Chem." volume="281" first="8072" last="8081">
            <title>The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Yang X.F."/>
                <person name="Blevins J.S."/>
                <person name="Machius M."/>
                <person name="Tomchick D.R."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="16418175"/>
            <dbReference type="DOI" id="10.1074/jbc.M511405200"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-353 IN COMPLEXES WITH ADENOSINE; INOSINE AND GUANOSINE</scope>
        <scope>PARTIAL PROTEIN SEQUENCE</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds purine nucleosides and may play a role in purine nucleoside uptake. May be part of an ABC-type nucleoside uptake system. Has highest affinity for guanosine, followed by inosine and adenosine. Has very low affinity for cytidine and does not bind thymidine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="2">Encoded in an operon with TP_0320, TP_0321, TP_0322 and TP_0323 that may code for an ABC-type nucleoside uptake system, with TP_0322 and/or TP_0323 encoding putative permeases, and TP_0319 encoding a ligand-binding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="X57836">
        <property type="protein sequence ID" value="CAA40968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71340">
        <property type="entry name" value="H71340"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881767.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="2FQW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.71 A"/>
        <property type="chains" value="A=36-353"/>
    </dbReference>
    <dbReference type="PDB" id="2FQX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=36-353"/>
    </dbReference>
    <dbReference type="PDB" id="2FQY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=36-353"/>
    </dbReference>
    <dbReference type="PDBsum" id="2FQW"/>
    <dbReference type="PDBsum" id="2FQX"/>
    <dbReference type="PDBsum" id="2FQY"/>
    <dbReference type="AlphaFoldDB" id="P29724"/>
    <dbReference type="SMR" id="P29724"/>
    <dbReference type="STRING" id="243276.TPANIC_0319"/>
    <dbReference type="TCDB" id="3.A.1.2.10">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65302">
        <property type="protein sequence ID" value="AAC65302"/>
        <property type="gene ID" value="TP_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0319"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_12"/>
    <dbReference type="OMA" id="LASMMKR"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="EvolutionaryTrace" id="P29724"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018007" description="Membrane lipoprotein TmpC">
        <location>
            <begin position="21"/>
            <end position="353"/>
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    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>inosine</name>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <position position="57"/>
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        <ligand>
            <name>inosine</name>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>inosine</name>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="232"/>
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        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
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    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>inosine</name>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
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        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
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    </feature>
    <feature type="binding site" evidence="2 7">
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        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
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        <ligand>
            <name>inosine</name>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 8">
        <location>
            <position position="280"/>
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        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
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            <position position="280"/>
        </location>
        <ligand>
            <name>guanosine</name>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 6">
        <location>
            <position position="280"/>
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        <ligand>
            <name>inosine</name>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
        </ligand>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1 3">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of lipid incorporation and cleavage at alternative processing site." evidence="3">
        <original>C</original>
        <variation>S</variation>
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; CAA40968." evidence="4" ref="1">
        <original>G</original>
        <variation>A</variation>
        <location>
            <position position="11"/>
        </location>
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    <feature type="sequence conflict" description="In Ref. 1; CAA40968." evidence="4" ref="1">
        <original>A</original>
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        <location>
            <position position="159"/>
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        <location>
            <begin position="41"/>
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    <feature type="strand" evidence="9">
        <location>
            <begin position="53"/>
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    <feature type="helix" evidence="9">
        <location>
            <begin position="56"/>
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    <feature type="strand" evidence="9">
        <location>
            <begin position="74"/>
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    <feature type="helix" evidence="9">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
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    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="99"/>
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    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="106"/>
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    <feature type="helix" evidence="9">
        <location>
            <begin position="109"/>
            <end position="118"/>
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    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="124"/>
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    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="137"/>
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    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="144"/>
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    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="166"/>
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    <feature type="turn" evidence="9">
        <location>
            <begin position="176"/>
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    <feature type="helix" evidence="9">
        <location>
            <begin position="179"/>
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    <feature type="strand" evidence="9">
        <location>
            <begin position="197"/>
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    <feature type="helix" evidence="9">
        <location>
            <begin position="209"/>
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    <feature type="strand" evidence="9">
        <location>
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    <feature type="helix" evidence="9">
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    <feature type="strand" evidence="9">
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    <feature type="helix" evidence="9">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="268"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="272"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="303"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="16418175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="1894360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="1894360"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="6">
        <source>
            <dbReference type="PDB" id="2FQW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="2FQX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="2FQY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2FQX"/>
        </source>
    </evidence>
    <sequence length="353" mass="37769" checksum="CB373138C8C4337D" modified="1998-12-15" version="2" precursor="true">MREKWVRAFAGVFCAMLLIGCSKSDRPQMGNAGGAEGGDFVVGMVTDSGDIDDKSFNQQVWEGISRFAQENNAKCKYVTASTDAEYVPSLSAFADENMGLVVACGSFLVEAVIETSARFPKQKFLVIDAVVQDRDNVVSAVFGQNEGSFLVGVAAALKAKEAGKSAVGFIVGMELGMMPLFEAGFEAGVKAVDPDIQVVVEVANTFSDPQKGQALAAKLYDSGVNVIFQVAGGTGNGVIKEARDRRLNGQDVWVIGVDRDQYMDGVYDGSKSVVLTSMVKRADVAAERISKMAYDGSFPGGQSIMFGLEDKAVGIPEENPNLSSAVMEKIRSFEEKIVSKEIVVPVRSARMMN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>P96118</accession>
    <name>TROC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Zinc transport system membrane protein TroC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">troC</name>
        <name type="ordered locus">TP_0165</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Gene" volume="197" first="47" last="64">
            <title>Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Stamm L.V."/>
                <person name="Porcella S.F."/>
                <person name="Frye J.G."/>
                <person name="Barnes N.Y."/>
                <person name="Howell J.K."/>
                <person name="Mueller S.L."/>
                <person name="Radolf J.D."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
            </authorList>
            <dbReference type="PubMed" id="9332349"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(97)00234-5"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Part of an ATP-driven transport system TroABCD for zinc.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cell membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="U55214">
        <property type="protein sequence ID" value="AAC45727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71357">
        <property type="entry name" value="B71357"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881612.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96118"/>
    <dbReference type="SMR" id="P96118"/>
    <dbReference type="IntAct" id="P96118">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0165"/>
    <dbReference type="TCDB" id="3.A.1.15.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65155">
        <property type="protein sequence ID" value="AAC65155"/>
        <property type="gene ID" value="TP_0165"/>
    </dbReference>
    <dbReference type="GeneID" id="57878707"/>
    <dbReference type="KEGG" id="tpa:TP_0165"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_0_0_12"/>
    <dbReference type="OMA" id="GAWLSYY"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0864">Zinc transport</keyword>
    <feature type="chain" id="PRO_0000171154" description="Zinc transport system membrane protein TroC">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="298" mass="31540" checksum="E4AE590B64BCC259" modified="1997-05-01" version="1">MHALMRLFSDYTLQNVVLGTLFLGLGSGLVGSFAVLRRQSLFGDAVSHATLPGIVIAFLLTGTKSTEILLLGAALSGLVGTVVMLMVMRTTKIDTDGAQGIVLGVFLGFGFLLLTHVQKSPQAAKAGLNKFILGQAATILQRDVLLIIAMEVVIGLLVLLFWKELKLSTFDRDFSAVQGFSPQLMEFMLTALIVVAVVVGVQAVGVILMSALLTAPAVAARQWTNSLRVLCALAALFGGVSGVSGSVVSAQVPRLSTGPVIVLVLTGIALVSIMLGPQRGVLYQLWRRRRVSLLQEEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q56328</accession>
    <name>RFUA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter riboflavin-binding protein RfuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Membrane lipoprotein TpN38(b)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rfuA</name>
        <name evidence="4" type="synonym">tpn38</name>
        <name type="ordered locus">TP_0298</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="FEMS Microbiol. Lett." volume="135" first="57" last="63">
            <title>Expression and sequence analysis of a Treponema pallidum gene, Tpn38(b), encoding an exported protein with homology to T. pallidum and Borrelia burgdorferi proteins.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
            </authorList>
            <dbReference type="PubMed" id="8598278"/>
            <dbReference type="DOI" id="10.1016/0378-1097(95)00429-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2013" name="MBio" volume="4" first="E00615" last="E00615">
            <title>Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes.</title>
            <authorList>
                <person name="Deka R.K."/>
                <person name="Brautigam C.A."/>
                <person name="Biddy B.A."/>
                <person name="Liu W.Z."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="23404400"/>
            <dbReference type="DOI" id="10.1128/mBio.00615-12"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 21-343 IN COMPLEX WITH RIBOFLAVIN</scope>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PALMITOYLATION AT CYS-20</scope>
        <scope>DIACYLGLYCEROL AT CYS-20</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Binds riboflavin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Monomer in solution (PubMed:23404400). The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="U12861">
        <property type="protein sequence ID" value="AAB02167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71341">
        <property type="entry name" value="D71341"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881747.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="4IIL">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.30 A"/>
        <property type="chains" value="A=21-343"/>
    </dbReference>
    <dbReference type="PDBsum" id="4IIL"/>
    <dbReference type="AlphaFoldDB" id="Q56328"/>
    <dbReference type="SMR" id="Q56328"/>
    <dbReference type="IntAct" id="Q56328">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0298"/>
    <dbReference type="EnsemblBacteria" id="AAC65287">
        <property type="protein sequence ID" value="AAC65287"/>
        <property type="gene ID" value="TP_0298"/>
    </dbReference>
    <dbReference type="GeneID" id="57878835"/>
    <dbReference type="KEGG" id="tpa:TP_0298"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_1_12"/>
    <dbReference type="OMA" id="FRVVGNW"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018008" description="ABC transporter riboflavin-binding protein RfuA">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>riboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>riboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>riboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>riboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 7">
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            <dbReference type="ChEBI" id="CHEBI:57986"/>
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            <position position="255"/>
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        <source>
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            <dbReference type="PubMed" id="23404400"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PDB" id="4IIL"/>
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    <sequence length="343" mass="37882" checksum="800687C5A1420C4D" modified="1996-11-01" version="1" precursor="true">MNGAVCVLSALIAVFTCFSCRPAVQDERAVRIAVFVPGFRHDSPVYAMLCDGVERAVTQERATGRSIGLDIIEAGPNQALWREKLAHLAAEQRYRLIVSSNPALPHVLEPILRQFPLQRFLVLDAYAPQEHSLITFRYNQWEQAYLAGHLSALVSASAMRFANADKKIGLIAGQSYPVMTQTIIPAFLAGARAVDPAFEVDVRVVGNWYDAAKSADLARILFHEGVDVMMPICGGANQGVLAAARELGFYVSWFDDNGYARAPGYVVGSSVMEQERLAYEQTLRCIRGELPSAGAWTLGVKDGYVRFIEEDPLYLQTVPEPIRVRQSALLRRIQSGELTLPVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q57321</accession>
    <name>MGLC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Galactoside transport system permease protein MglC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mglC</name>
        <name type="ordered locus">TP_0686</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Gene" volume="177" first="115" last="121">
            <title>A mgl-like operon in Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Porcella S.F."/>
                <person name="Popova T.G."/>
                <person name="Hagman K.E."/>
                <person name="Penn C.W."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="8921855"/>
            <dbReference type="DOI" id="10.1016/0378-1119(96)00286-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="DNA Seq." volume="6" first="293" last="298">
            <title>Identification and sequences of the Treponema pallidum mglA and mglC genes.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Young N.R."/>
                <person name="Frye J.G."/>
                <person name="Hardham J.M."/>
            </authorList>
            <dbReference type="PubMed" id="8988365"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AAC44586.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
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        <property type="entry name" value="MglC"/>
    </dbReference>
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        <property type="entry name" value="PTHR32196:SF18"/>
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    </dbReference>
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        <property type="entry name" value="BPD_transp_2"/>
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    <proteinExistence type="inferred from homology"/>
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    <feature type="chain" id="PRO_0000060109" description="Galactoside transport system permease protein MglC homolog">
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            <end position="531"/>
        </location>
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    </feature>
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    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="481"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="503"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="531" mass="57875" checksum="B92EFA6BC8ABF299" modified="1996-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUJ5</accession>
    <name>F7IUJ5_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein (Mcp1)</fullName>
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    </gene>
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65035.1"/>
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        <property type="nucleotide sequence ID" value="NC_000919.1"/>
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    <dbReference type="EnsemblBacteria" id="AAC65035">
        <property type="protein sequence ID" value="AAC65035"/>
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    </dbReference>
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        <property type="protein sequence ID" value="AGN75261"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243276.9.peg.36"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:chemotaxis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
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        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="292"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="251"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="597" mass="64618" checksum="1AECD46A7EF0B5BD" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7IVD2</accession>
    <name>F7IVD2_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding protein (YlxH-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
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        <property type="protein sequence ID" value="AAC65678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="D71290"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0712"/>
    <dbReference type="EnsemblBacteria" id="AAC65678">
        <property type="protein sequence ID" value="AAC65678"/>
        <property type="gene ID" value="TP_0712"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75887">
        <property type="protein sequence ID" value="AGN75887"/>
        <property type="gene ID" value="TPANIC_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0712"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.702"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="FKVAKNN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
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        <property type="entry name" value="FlhG"/>
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        <property type="entry name" value="MinD_FleN"/>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="5"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAC65678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O07950</accession>
    <name>TPN32_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Membrane lipoprotein TpN32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>29 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tpn32</name>
        <name type="ordered locus">TP_0821</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1997-05" db="EMBL/GenBank/DDBJ databases">
            <title>Treponema pallidum 29K protein is homologous to a lipoprotein present in Pasteurella hemolytica and in Haemophilus influenzae type b.</title>
            <authorList>
                <person name="Porcella S.F."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="submission" date="1997-06" db="EMBL/GenBank/DDBJ databases">
            <title>Treponema pallidum lipoprotein homologue.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="U97358">
        <property type="protein sequence ID" value="AAB63362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U93844">
        <property type="protein sequence ID" value="AAB61267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="G71275"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882265.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="1XS5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A=28-268"/>
    </dbReference>
    <dbReference type="PDBsum" id="1XS5"/>
    <dbReference type="AlphaFoldDB" id="O07950"/>
    <dbReference type="SMR" id="O07950"/>
    <dbReference type="STRING" id="243276.TPANIC_0821"/>
    <dbReference type="EnsemblBacteria" id="AAC65789">
        <property type="protein sequence ID" value="AAC65789"/>
        <property type="gene ID" value="TP_0821"/>
    </dbReference>
    <dbReference type="GeneID" id="57879338"/>
    <dbReference type="KEGG" id="tpa:TP_0821"/>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067080_0_0_12"/>
    <dbReference type="OMA" id="YQDDAES"/>
    <dbReference type="OrthoDB" id="1230456at2"/>
    <dbReference type="EvolutionaryTrace" id="O07950"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000019750" description="Membrane lipoprotein TpN32">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
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            <end position="36"/>
        </location>
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        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="78"/>
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        </location>
    </feature>
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        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="101"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="189"/>
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        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="199"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="turn" evidence="3">
        <location>
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            <end position="212"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
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            <end position="246"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="1XS5"/>
        </source>
    </evidence>
    <sequence length="268" mass="29081" checksum="AB21F8A07A88F691" modified="1997-07-01" version="1" precursor="true">MKGKTVSAALVGKLIALSVGVVACTQVKDETVGVGVLSEPHARLLEIAKEEVKKQHIELRIVEFTNYVALNEAVMRGDILMNFFQHVPHMQQFNQEHNGDLVSVGNVHVEPLALYSRTYRHVSDFPAGAVIAIPNDSSNEARALRLLEAAGFIRMRAGSGLFATVEDVQQNVRNVVLQEVESALLPRVFDQVDGAVINGNYAIMAGLSARRDGLAVEPDASAYANVLVVKRGNEADARVQAVLRALCGGRVRTYLKERYKGGEVAPAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O30405</accession>
    <name>GLPQ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Glycerophosphodiester phosphodiesterase</fullName>
            <shortName>Glycerophosphoryl diester phosphodiesterase</shortName>
            <shortName evidence="8">Gpd</shortName>
            <ecNumber>3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">glpQ</name>
        <name type="synonym">glp</name>
        <name type="ordered locus">TP_0257</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="FEMS Microbiol. Lett." volume="154" first="303" last="310">
            <title>Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue.</title>
            <authorList>
                <person name="Stebeck C.E."/>
                <person name="Shaffer J.M."/>
                <person name="Arroll T.W."/>
                <person name="Lukehart S.A."/>
                <person name="van Voorhis W.C."/>
            </authorList>
            <dbReference type="PubMed" id="9311129"/>
            <dbReference type="DOI" id="10.1016/S0378-1097(97)00346-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="Infect. Immun." volume="65" first="4179" last="4189">
            <title>Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Robinson E.J."/>
                <person name="Li M."/>
                <person name="Shevchenko O.V."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="9317025"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1998" name="Infect. Immun." volume="66" first="5763" last="5770">
            <title>Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase.</title>
            <authorList>
                <person name="Cameron C.E."/>
                <person name="Castro C."/>
                <person name="Lukehart S.A."/>
                <person name="Van Voorhis W.C."/>
            </authorList>
            <dbReference type="PubMed" id="9826352"/>
        </citation>
        <scope>FUNCTION IN HOST INFECTION</scope>
        <scope>BIOTECHNOLOGY</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1999" name="Infect. Immun." volume="67" first="2266" last="2276">
            <title>Membrane topology and cellular location of the Treponema pallidum glycerophosphodiester phosphodiesterase (GlpQ) ortholog.</title>
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Sellati T.J."/>
                <person name="Cox D.L."/>
                <person name="Shevchenko O.V."/>
                <person name="Robinson E.J."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="10225883"/>
        </citation>
        <scope>PALMITOYLATION</scope>
        <scope>EXPRESSION IN E.COLI</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Clin. Microbiol." volume="41" first="3668" last="3674">
            <title>Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum.</title>
            <authorList>
                <person name="Van Voorhis W.C."/>
                <person name="Barrett L.K."/>
                <person name="Lukehart S.A."/>
                <person name="Schmidt B."/>
                <person name="Schriefer M."/>
                <person name="Cameron C.E."/>
            </authorList>
            <dbReference type="PubMed" id="12904373"/>
            <dbReference type="DOI" id="10.1128/JCM.41.8.3668-3674.2003"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2005" name="J. Bacteriol." volume="187" first="6499" last="6508">
            <title>TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability.</title>
            <authorList>
                <person name="Hazlett K.R."/>
                <person name="Cox D.L."/>
                <person name="Decaffmeyer M."/>
                <person name="Bennett M.P."/>
                <person name="Desrosiers D.C."/>
                <person name="La Vake C.J."/>
                <person name="La Vake M.E."/>
                <person name="Bourell K.W."/>
                <person name="Robinson E.J."/>
                <person name="Brasseur R."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="16159783"/>
            <dbReference type="DOI" id="10.1128/JB.187.18.6499-6508.2005"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PALMITOYLATION</scope>
        <scope>EXPRESSION IN E.COLI</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Binds human IgA, IgD and the Fc portion of IgG but not IgM, which may contribute to evasion of the human immune system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10 11">Lipid-anchor</topology>
            <orientation evidence="10">Periplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6 7">Has also been identified in cell outer membrane, but this may be incorrect (PubMed:9826352, PubMed:9317025).</text>
    </comment>
    <comment type="PTM">
        <text evidence="3 5">Palmitoylated upon expression of a fusion protein with first 40 residues fused to PhoA in E.coli.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="4 7">Immunization of rabbits with this protein partially protects against subsequent intradermal challenge, suggesting it may be a viable vaccine candidate (PubMed:9826352). Recognized by sera from 39/43 syphilis patients, it shows promise as a diagnostic antigen (PubMed:12904373).</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The outer membrane of T.pallidum has no lipopolysaccharides, few proteins and is a fluid and very fragile bilayer. Its lack of surface antigenicity is thought to contribute to the ability of the pathogen to evade the human immune system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46"/>
    <dbReference type="EMBL" id="AF004286">
        <property type="protein sequence ID" value="AAB81591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U95744">
        <property type="protein sequence ID" value="AAC08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71346">
        <property type="entry name" value="F71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881706.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O30405"/>
    <dbReference type="SMR" id="O30405"/>
    <dbReference type="IntAct" id="O30405">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0257"/>
    <dbReference type="EnsemblBacteria" id="AAC65246">
        <property type="protein sequence ID" value="AAC65246"/>
        <property type="gene ID" value="TP_0257"/>
    </dbReference>
    <dbReference type="GeneID" id="57878798"/>
    <dbReference type="KEGG" id="tpa:TP_0257"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030226_1_0_12"/>
    <dbReference type="OMA" id="CRHENDI"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="BRENDA" id="3.1.4.46">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000012596" description="Glycerophosphodiester phosphodiesterase">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="10225883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="12904373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="16159783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="9317025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="9826352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="9826352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000305" key="10">
        <source>
            <dbReference type="PubMed" id="10225883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11">
        <source>
            <dbReference type="PubMed" id="16159783"/>
        </source>
    </evidence>
    <sequence length="356" mass="41014" checksum="7AD414E70A4C799A" modified="1998-01-01" version="1" precursor="true">MRGTYCVTLWGGVFAALVAGCASERMIVAYRGAAGYVPEHTFASKVLAFAQGADYLQQDVVLSKDNQLIVAQSHILDNMTDVAEKFPRRQRADGHFYVIDFTVEELSLLRATNSFYTRGKRHTPVYGQRFPLWKPGFRLHTFEEELQFIRGLEQTTGKKIGIYSEIKVPWFHHQEGKDIAALTLALLKKYGYQSRSDLVYVQTYDFNELKRIKRELLPKYEMNVKLIQRVAYTDQRETQEKDSRGKWINYNYNWMFEPGGMQKIAKYADGVGPDWRMLIENEWSKVGAVRLSPMVSAIQDAKLECHVHTVRKETLPSYARTMDEMFSILFKQTGANVVLTDFPDLGVKFLGKPARY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O66103</accession>
    <accession>O83915</accession>
    <name>YIDC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidC</name>
        <name type="ordered locus">TP_0949</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="1997-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Radolf J.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 456-622</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65906" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65906.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U97573">
        <property type="protein sequence ID" value="AAC08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71261">
        <property type="entry name" value="C71261"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342847.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O66103"/>
    <dbReference type="SMR" id="O66103"/>
    <dbReference type="STRING" id="243276.TPANIC_0949"/>
    <dbReference type="EnsemblBacteria" id="AAC65906">
        <property type="protein sequence ID" value="AAC65906"/>
        <property type="gene ID" value="TP_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0949"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_2_0_12"/>
    <dbReference type="OMA" id="MPIMFFF"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000124761" description="Membrane protein insertase YidC">
        <location>
            <begin position="1"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="622" mass="70121" checksum="04C70CA8E8646E8C" modified="2003-11-21" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83059</accession>
    <name>SYFB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
        <name type="ordered locus">TP_0015</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71377">
        <property type="entry name" value="D71377"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881464.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83059"/>
    <dbReference type="SMR" id="O83059"/>
    <dbReference type="IntAct" id="O83059">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0015"/>
    <dbReference type="EnsemblBacteria" id="AAC65007">
        <property type="protein sequence ID" value="AAC65007"/>
        <property type="gene ID" value="TP_0015"/>
    </dbReference>
    <dbReference type="GeneID" id="57878553"/>
    <dbReference type="KEGG" id="tpa:TP_0015"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_12"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00284">
        <property type="entry name" value="Phe_tRNA_synth_beta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022918">
        <property type="entry name" value="Phe_tRNA_ligase_beta2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000126997" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="327"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="604" mass="67190" checksum="553577AA0EE4B124" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83060</accession>
    <name>O83060_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71377">
        <property type="entry name" value="E71377"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881465.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0016"/>
    <dbReference type="EnsemblBacteria" id="AAC65008">
        <property type="protein sequence ID" value="AAC65008"/>
        <property type="gene ID" value="TP_0016"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75238">
        <property type="protein sequence ID" value="AGN75238"/>
        <property type="gene ID" value="TPANIC_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0016"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.14"/>
    <dbReference type="eggNOG" id="COG0630">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014785_0_0_12"/>
    <dbReference type="OMA" id="DWVYVNN"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="613"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="857" mass="95802" checksum="5D68A28EBD540E74" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83122</accession>
    <name>Y084_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0084</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0084</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71367">
        <property type="entry name" value="E71367"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881533.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83122"/>
    <dbReference type="SMR" id="O83122"/>
    <dbReference type="IntAct" id="O83122">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0084"/>
    <dbReference type="EnsemblBacteria" id="AAC65088">
        <property type="protein sequence ID" value="AAC65088"/>
        <property type="gene ID" value="TP_0084"/>
    </dbReference>
    <dbReference type="GeneID" id="57878624"/>
    <dbReference type="KEGG" id="tpa:TP_0084"/>
    <dbReference type="eggNOG" id="ENOG5032FFX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2636990_0_0_12"/>
    <dbReference type="OrthoDB" id="1911794at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202188" description="Uncharacterized protein TP_0084">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <sequence length="77" mass="8224" checksum="09046A5D92463942" modified="1998-11-01" version="1">MVVNAVVGADEASARLREYCSGLPDVEKKIAESTSPEGAKLVSDFGIGSVPMVVILDEDSSELFRTADIGELEKFFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83132</accession>
    <name>PTAS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphate acetyltransferase</fullName>
            <ecNumber>2.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphotransacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pta</name>
        <name type="ordered locus">TP_0094</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71366">
        <property type="entry name" value="B71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881543.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83132"/>
    <dbReference type="SMR" id="O83132"/>
    <dbReference type="IntAct" id="O83132">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0094"/>
    <dbReference type="EnsemblBacteria" id="AAC65090">
        <property type="protein sequence ID" value="AAC65090"/>
        <property type="gene ID" value="TP_0094"/>
    </dbReference>
    <dbReference type="GeneID" id="57878634"/>
    <dbReference type="KEGG" id="tpa:TP_0094"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019723_0_1_12"/>
    <dbReference type="OMA" id="TMLVKMG"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000179150" description="Phosphate acetyltransferase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="336" mass="36538" checksum="C22586DE303135AE" modified="1998-11-01" version="1">MTFVESMQRRAVLAQKRLVLPEACEQRTLEAARLIVFRNIAAKVFLVGCERDIKNTADRCGIDLTDMVVIDPSVSKHRDQFAERYFQKRKHKGISLAQAAEDMRDPLRFAAMMLDQGHADAMVAGAENTTARVLRAGLTIIGTLPSVKTASSCFVMDTNNPRLGGTRGLFIFSDCAVIPTPTAEQLADIACSAAESCRTFIGEEPTVALLSYSTKGSGGDSDENILRVREAVRILHERRVDFTFDGELQLDAALVPKITEKKAPHSPITGKVNTLVFPDLSSGNIGYKLVQRLSDADAYGPFLQGFAKPLSDLSRGCSVEDIVAACAVTLVQSNGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83133</accession>
    <name>Y095_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>TPR repeat-containing protein TP_0095</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0095</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71366">
        <property type="entry name" value="C71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881544.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83133"/>
    <dbReference type="SMR" id="O83133"/>
    <dbReference type="IntAct" id="O83133">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0095"/>
    <dbReference type="EnsemblBacteria" id="AAC65099">
        <property type="protein sequence ID" value="AAC65099"/>
        <property type="gene ID" value="TP_0095"/>
    </dbReference>
    <dbReference type="GeneID" id="57878635"/>
    <dbReference type="KEGG" id="tpa:TP_0095"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422062_0_0_12"/>
    <dbReference type="OMA" id="YSERASC"/>
    <dbReference type="OrthoDB" id="215967at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <feature type="chain" id="PRO_0000106452" description="TPR repeat-containing protein TP_0095">
        <location>
            <begin position="1"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 4">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 5">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 6">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 7">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 8">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 9">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <sequence length="648" mass="72380" checksum="32A2A994F991FE69" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83149</accession>
    <name>RP54_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase sigma-54 factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpoN</name>
        <name type="ordered locus">TP_0111</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sigma-54 factor family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="F71364"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAC65101">
        <property type="protein sequence ID" value="AAC65101"/>
        <property type="gene ID" value="TP_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0111"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_0_1_12"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA-templated transcription, initiation"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Sigma54_CBD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
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    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000205545" description="RNA polymerase sigma-54 factor">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RPON box">
        <location>
            <begin position="458"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="475" mass="54280" checksum="2464059A019A6190" modified="1998-11-01" version="1">MQQLVQQQRLVLNQRLVHGLCLLQLSRGDLKTEVLRAVQRNPLLEIRPSSARRTGKACYLSLGDRRERMRARDRFQQLLENQPDKQVDNIRAVLREQVFYQKHEAIVLDLACAFIQMLDDHGFFSISPAIFQNMCGSMPTALQEKIPQAIALIQRLEPQGCAVFNFKESLAVQARLRFERFSDPLYRCVINLLTHHSELLFCSDNMCDGRVSVHALTTQINSMGLCVQKVSSNDVKDILLLIKELHPFPGKCVSNAQRADTNMLLEPDVLITKTAHGFVTQINCTGIPTVVFRNDYCMHSKAAEKNHALKACMHDALSLVSMLSYRERTLLDIAKTIVHYQCGFFDHGPAKLTPLRMTDVAHRTGLSVSTVSRIVRDKWLQYGSQHFSLRYFFSPRVLSTEEYRDRSSLGQNYPSSPHSKVSVKYRISRLIQEVRTQRISLSDRRIAQLLGEQGIKCARRTVNKYRSELRTCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83176</accession>
    <name>O83176_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+ transport protein (NtpJ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AAC65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71360">
        <property type="entry name" value="F71360"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881588.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83176">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0140"/>
    <dbReference type="EnsemblBacteria" id="AAC65128">
        <property type="protein sequence ID" value="AAC65128"/>
        <property type="gene ID" value="TP_0140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75360">
        <property type="protein sequence ID" value="AGN75360"/>
        <property type="gene ID" value="TPANIC_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0140"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.145"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026429_3_1_12"/>
    <dbReference type="OMA" id="MFIGSAP"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="152"/>
        </location>
    </feature>
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            <end position="183"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="575" mass="62350" checksum="424E11068DBA1430" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83181</accession>
    <name>O83181_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid--CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">Nichols</strain>
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    </reference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
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        <location>
            <begin position="33"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
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    </evidence>
    <sequence length="656" mass="72223" checksum="136AB402E51C1768" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83188</accession>
    <name>O83188_TREPA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="G71358"/>
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    </dbReference>
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        <property type="entry name" value="DUF212"/>
    </dbReference>
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        <property type="entry name" value="PTHR31446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="163" mass="17513" checksum="CD9F99AC7E61C115" modified="1998-11-01" version="1">MDGGYFLGQLHAVFSGEVFLSATCSWLASQVIKVAIACRRSAIRSVHGFFDFAVWRTGGMPSSHSALVSALTLSFALKCGLHSDLFIFSFFSAIIVVRDALGVRRSSGLQAEALNSLGARVSEKLDFSFRPVREIHGHKPLEVVVGVAVGIVTSALFYSSMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83193</accession>
    <name>O83193_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
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            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="228" mass="26478" checksum="9C8CEA3CBE5C7E18" modified="1998-11-01" version="1">MLNWSIPVIRHILFDIDNTLYSCTNPIEMAITQRIHTFVAHFLHVSCEEARALRQRTKHLYATTFEWLKAEHNLIHDEHYFRAVYPPTEIQELQYDPMLRPFLQSLHMPLTALTNAPRVHAQRVLDFFHLSDLFLDVFDITYHAGKGKPHHSCFVRTLEAVHKTVQETLFVDDCLMHVRAFIALGGHAVLVDERDCHAELPPSARMTRVKTIYELPAHLARLAQGDNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83210</accession>
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        <recommendedName>
            <fullName>Uncharacterized protein TP_0180</fullName>
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    </protein>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
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                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
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                <person name="Watthey L."/>
                <person name="Weidman J."/>
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            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="F71353"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0180"/>
    <dbReference type="EnsemblBacteria" id="AAC65195">
        <property type="protein sequence ID" value="AAC65195"/>
        <property type="gene ID" value="TP_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0180"/>
    <dbReference type="HOGENOM" id="CLU_3085912_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202211" description="Uncharacterized protein TP_0180">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <sequence length="52" mass="5518" checksum="95881BBF07666F32" modified="1998-11-01" version="1">MRIESSPLPLTACLHCLPHLHPCFCPYPPPPGGNDTGTAGAFRTRALPSFTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83218</accession>
    <name>RS10_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name type="ordered locus">TP_0188</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71354">
        <property type="entry name" value="F71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881635.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83218"/>
    <dbReference type="SMR" id="O83218"/>
    <dbReference type="IntAct" id="O83218">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0188"/>
    <dbReference type="EnsemblBacteria" id="AAC65173">
        <property type="protein sequence ID" value="AAC65173"/>
        <property type="gene ID" value="TP_0188"/>
    </dbReference>
    <dbReference type="GeneID" id="57878726"/>
    <dbReference type="KEGG" id="tpa:TP_0188"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_12"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146625" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="102" mass="11584" checksum="2C73616A8A01E9E4" modified="1998-11-01" version="1">MARERIRVKLCGFDVELVDQSSRAIVHAVQKAGAEVLGPIPLPTRMHKFTVLRSPHVNKKSREQFEMRTHKRLIDIIEPSQEVMNALMGLELSAGVDVRIKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83221</accession>
    <name>RL23_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">TP_0191</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71355">
        <property type="entry name" value="A71355"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881638.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83221"/>
    <dbReference type="SMR" id="O83221"/>
    <dbReference type="STRING" id="243276.TPANIC_0191"/>
    <dbReference type="EnsemblBacteria" id="AAC65176">
        <property type="protein sequence ID" value="AAC65176"/>
        <property type="gene ID" value="TP_0191"/>
    </dbReference>
    <dbReference type="GeneID" id="57878729"/>
    <dbReference type="KEGG" id="tpa:TP_0191"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_12"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129429" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="94" mass="10512" checksum="DC5421F06AEA95CD" modified="1998-11-01" version="1">MEHTDVVIAPVLTEKSNALRQQGKYVFRVAARATKIQIKQAVTQLFGVTVRRCTVMNVFGKKRRVRHRTGRTSGWKKAIVHVAAGQSIGVLERA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83228</accession>
    <name>RS17_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">TP_0198</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71355">
        <property type="entry name" value="H71355"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83228"/>
    <dbReference type="SMR" id="O83228"/>
    <dbReference type="IntAct" id="O83228">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0198"/>
    <dbReference type="EnsemblBacteria" id="AAC65183">
        <property type="protein sequence ID" value="AAC65183"/>
        <property type="gene ID" value="TP_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0198"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_2_12"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000128494" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="84" mass="9959" checksum="3F2AC9EDE2528F1E" modified="1998-11-01" version="1">MKRPERRTLVGLVTSDKMHKTVTVRITTKKLHALYKKYVSRSKKYQAHDEENTARAGDVVRIAESRPLSRRKRWRLVEIVERAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83233</accession>
    <name>RS8_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">TP_0203</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71356">
        <property type="entry name" value="E71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881650.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83233"/>
    <dbReference type="SMR" id="O83233"/>
    <dbReference type="STRING" id="243276.TPANIC_0203"/>
    <dbReference type="EnsemblBacteria" id="AAC65187">
        <property type="protein sequence ID" value="AAC65187"/>
        <property type="gene ID" value="TP_0203"/>
    </dbReference>
    <dbReference type="GeneID" id="57878740"/>
    <dbReference type="KEGG" id="tpa:TP_0203"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_12"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126515" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="132" mass="14756" checksum="7544E5E7B632D0D7" modified="1998-11-01" version="1">MGVSDPVADMLTKIRNAARAGHEKVDVPSSKLKVEVVKILKTEGYIRNFRKVEEDGSGCIRVFLKYDDNETSVIHGIERISTPGRRVYSGYKTLRRVYNGYGTLIVSTSLGVTTGRHAREQRVGGELICKVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83235</accession>
    <name>RL18_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">TP_0205</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71356">
        <property type="entry name" value="G71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881652.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83235"/>
    <dbReference type="SMR" id="O83235"/>
    <dbReference type="STRING" id="243276.TPANIC_0205"/>
    <dbReference type="EnsemblBacteria" id="AAC65189">
        <property type="protein sequence ID" value="AAC65189"/>
        <property type="gene ID" value="TP_0205"/>
    </dbReference>
    <dbReference type="GeneID" id="57878742"/>
    <dbReference type="KEGG" id="tpa:TP_0205"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_12"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131376" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="120" mass="13657" checksum="2305990773F4FAA8" modified="1998-11-01" version="1">MLRKCSDKQRKRMKRKVHIRKRVYGTAVRPRMTVFRSNRNISVQVIDDDARSTLASVSTLEKDFVLLRANVSSGLQIGEEIGRRLLEKHIDTVIFDRNGYLYHGVVAAVADGARKAGVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83257</accession>
    <name>O83257_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_0229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71351">
        <property type="entry name" value="C71351"/>
    </dbReference>
    <dbReference type="IntAct" id="O83257">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0229"/>
    <dbReference type="EnsemblBacteria" id="AAC65215">
        <property type="protein sequence ID" value="AAC65215"/>
        <property type="gene ID" value="TP_0229"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75442">
        <property type="protein sequence ID" value="AGN75442"/>
        <property type="gene ID" value="TPANIC_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0229"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.233"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_0_12"/>
    <dbReference type="OMA" id="RPWLIAE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="113"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="277" mass="30603" checksum="F24D9FD0BD0BB904" modified="1998-11-01" version="1">MQGSGTVMYAVYGRLSPMHAGDRESIARFVRVVRDCLDLFRTEGIGPRPRNDSVILPNAACSPRNHAGKRAQSTADACVRSSDGSVYTDETLREEIFACRACELYQRRTHAVVGEGVADADVLVVGEAPGAEEDRSGRPFVGRSGKLLDAMLAAIGLSRQQNCYITNVVKCRPPRNRTPTPHETACCARFLHAHLTLHRPCAILVLGRCAAQHMLQTTDGIGKLRGRFFTYQGIPLLATYHPSALLRDEALKRPAWEDLKTFRARLLQLKQDAHMPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83272</accession>
    <name>RS7_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">TP_0244</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71347">
        <property type="entry name" value="G71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881692.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83272"/>
    <dbReference type="SMR" id="O83272"/>
    <dbReference type="STRING" id="243276.TPANIC_0244"/>
    <dbReference type="EnsemblBacteria" id="AAC65233">
        <property type="protein sequence ID" value="AAC65233"/>
        <property type="gene ID" value="TP_0244"/>
    </dbReference>
    <dbReference type="GeneID" id="57878786"/>
    <dbReference type="KEGG" id="tpa:TP_0244"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_12"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124373" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17882" checksum="3B2AD2275919E427" modified="1998-11-01" version="1">MGRKRRVSRRVPPPDARYNSVVLAKFICRMMLAGKKATAVGIMYDCLERIQQRTGEEPLPVFTKALENVKPAVEVKSRRVGGSTYQVPMEIRETRREALGMRWIIGAARRRSGRGMSERLAAEILDAYHSTGTAFKRKEDTHRMAEANKAFSHYRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-02-23" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83276</accession>
    <name>Y248_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0248</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0248</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71348">
        <property type="entry name" value="C71348"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881696.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83276">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65241">
        <property type="protein sequence ID" value="AAC65241"/>
        <property type="gene ID" value="TP_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0248"/>
    <dbReference type="HOGENOM" id="CLU_1895266_0_0_12"/>
    <dbReference type="OMA" id="CWTLLLM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014244" description="Uncharacterized lipoprotein TP_0248">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="134" mass="14843" checksum="75C5A52EB2E99F1F" modified="1998-11-01" version="1" precursor="true">MWHLRCSNWRGSGVFGMCFSLSGCVMGQWCVSRAIVRGHTQGGAVREVVRELLLGPQHHGYARLVDPAVRPLSCFSRGDTLYIDLPVGVLSPKYRTCSLHRAYELXERSVVLNCAPVKRVCFYVGGRAGFESDG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83280</accession>
    <name>O83280_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71348">
        <property type="entry name" value="H71348"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0253"/>
    <dbReference type="EnsemblBacteria" id="AAC65238">
        <property type="protein sequence ID" value="AAC65238"/>
        <property type="gene ID" value="TP_0253"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75465">
        <property type="protein sequence ID" value="AGN75465"/>
        <property type="gene ID" value="TPANIC_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0253"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.257"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_4_3_12"/>
    <dbReference type="OMA" id="TDVVICD"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="137" mass="14872" checksum="D498555F71A22D23" modified="1998-11-01" version="1">MALKRVSEGHGKTVLGAKTVFDGVLRFKGNLHIRGKFSGAIDAQGCLTIAPGAVCAVQYARAVSIFVEGEVRGNLTVVDRVEMRDGSRVFGDVTASRIKICDGVTFEGSVCMTREGNVSKRDLFSVQSEQLKEHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83289</accession>
    <name>O83289_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter, permease protein (BraC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71345">
        <property type="entry name" value="C71345"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881714.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65254">
        <property type="protein sequence ID" value="AAC65254"/>
        <property type="gene ID" value="TP_0265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75477">
        <property type="protein sequence ID" value="AGN75477"/>
        <property type="gene ID" value="TPANIC_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0265"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.285"/>
    <dbReference type="eggNOG" id="COG1114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036807_0_1_12"/>
    <dbReference type="OMA" id="IWPAGPI"/>
    <dbReference type="OrthoDB" id="1533843at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="455" mass="49080" checksum="135B84925FCCC22B" modified="1998-11-01" version="1">MIHTHTLSLSFMLFSFFFGAGNLILPPLLGKHAGTTLATALLGFATSAVLIPIAGLITIAHAGGIVPLSERVGKRFAHLYPAITLLVIGPALSIPRAGIVPFALAIAPLIHRANTTLLAQLIYTTCFFIVSYWLCMRPHTLSNTLGKVLTPALLVLVLLLFLASFTPTLGPYLPAQGAYATHIPFSQGFLDGYLTTDALASLMFGNMILTYLHRTRYTTAPFPPTPANTPADMRTVAWIAGVMLFFTYGVLAHLGALSARQLPHTVNGAHILASVSRHLFGKAGIALLGLIFTIACLTTCAGLLVCVSEYFHKRAPRVSYLCWIRLFTISSFALANTGLERILAYGTPLLMILYPISLVLIGISHLERLIRIPRAAYRLTVWSAGTLSTCAVGTPLVAHTRIGHVLNTLIHTLPLAQEQLCWLIPSAAVLILSTAHARLREKTCTPRGTLPLTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83294</accession>
    <name>O83294_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polynucleotide adenylyltransferase (PcnA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71345">
        <property type="entry name" value="H71345"/>
    </dbReference>
    <dbReference type="IntAct" id="O83294">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0270"/>
    <dbReference type="EnsemblBacteria" id="AAC65258">
        <property type="protein sequence ID" value="AAC65258"/>
        <property type="gene ID" value="TP_0270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75481">
        <property type="protein sequence ID" value="AGN75481"/>
        <property type="gene ID" value="TPANIC_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0270"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.274"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_3_1_12"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="310"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="478" mass="53320" checksum="119F46E4721BAA50" modified="1998-11-01" version="1">MRVFPVCPLLREVSERFIRAGFCIYVVGGAVRDFLLNRSAHDWDLATDAPPERVRMLFRRTVPTGIEHGTVTILFRGHSIECTTFRVESDYSDRRHPDSVCFAARIEDDLARRDFTVNAFAAALPSGEIIDVCGGYADLRNGLICSVGDAHARFSEDALRPLRAVRFAAQLSFSIEARTREAIIALRAHTARISRERVRDELSKMLCTPRPSIALRLMEETGLLHTLFPALAQVCGRNEGEEKETQDSLQVSPQQRRDARTFAACAFAACDRVPAELAVRLAALLFPLAHYRTLPASGTGAALFICPPALAEARELLRGLKYPNYLTAQVCHLVAHARFTPHECWSEGTLRRFVVTVGTTQLESLCVLRRAYLADDDYRISAQPGVSCENAREGKKMQEQFEIFVTRVRRVAAQLPVHGIRDLAVNGRDLIAQGIPPGPTIGHILNALFDMVLMQPSRNTRPQLLEHAQEIVRTMAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83298</accession>
    <name>O83298_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxycytidylate deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71342">
        <property type="entry name" value="E71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881723.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83298">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0274"/>
    <dbReference type="EnsemblBacteria" id="AAC65262">
        <property type="protein sequence ID" value="AAC65262"/>
        <property type="gene ID" value="TP_0274"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75485">
        <property type="protein sequence ID" value="AGN75485"/>
        <property type="gene ID" value="TPANIC_0274"/>
    </dbReference>
    <dbReference type="GeneID" id="57878818"/>
    <dbReference type="KEGG" id="tpa:TP_0274"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.278"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_0_12"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="OrthoDB" id="1544522at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18410" checksum="768FE3E0D775C663" modified="1998-11-01" version="1">MGQREELVTRPSWDEYFMEVCHAIAKRATCDRGRAGCVIARDHHLLVTGYAGAPRGLLHCDEHGHQLRTVQHEDGTCTQHCVRTVHAEQNALCQAARLGIGLEGATLYCTMTPCRTCAMLIINCGIVRVVAEKRYQTATESIMLFAQAQIALEHIYQNPAEYGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83315</accession>
    <name>O83315_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71344">
        <property type="entry name" value="F71344"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881740.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83315">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0291"/>
    <dbReference type="EnsemblBacteria" id="AAC65283">
        <property type="protein sequence ID" value="AAC65283"/>
        <property type="gene ID" value="TP_0291"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75496">
        <property type="protein sequence ID" value="AGN75496"/>
        <property type="gene ID" value="TPANIC_0291"/>
    </dbReference>
    <dbReference type="GeneID" id="57878829"/>
    <dbReference type="KEGG" id="tpa:TP_0291"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.292"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_6_0_12"/>
    <dbReference type="OMA" id="IPFIKPW"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="293" mass="32306" checksum="9AA399CA732E9EBC" modified="1998-11-01" version="1">MVRSARSEYKCRLCARCDGYGCRGQLPGMGGVFNSANFIANCLAWKKYVPQRHELPVVRLAPMTGAVENVGYPDEVSFYYRLIEAVSGTGVLLSVGDGCPDIKLQSGIAALRSFKKKAAVFIKPYVNKKIFERIEWGRDVAEFVGVDIDAYHIVTMRDKVQLEKKTPTHLRAVRRFAKLPIVVKGIFAPRDVELVRELKPDVAIVSNHGGRVETARGSTADFLFEYGGELARCAGEVWVDGGIRSYAHLCAARELGAQQVLIGRPFITALLKGGKGGVQLLVRNMTDRSVRCV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83352</accession>
    <name>Y332_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0332</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0332</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71337">
        <property type="entry name" value="B71337"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83352"/>
    <dbReference type="IntAct" id="O83352">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65327">
        <property type="protein sequence ID" value="AAC65327"/>
        <property type="gene ID" value="TP_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0332"/>
    <dbReference type="HOGENOM" id="CLU_3278191_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202237" description="Uncharacterized protein TP_0332">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <sequence length="41" mass="4642" checksum="0E5DCA6EC6E4D6D5" modified="1998-11-01" version="1">MRAECSAFRYFLKGDGDLVLSVYIRVLCVFLEPVQRGSCSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-12-13" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83357</accession>
    <name>RSMA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">TP_0337</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71337">
        <property type="entry name" value="G71337"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881785.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83357"/>
    <dbReference type="SMR" id="O83357"/>
    <dbReference type="STRING" id="243276.TPANIC_0337"/>
    <dbReference type="PRIDE" id="O83357"/>
    <dbReference type="EnsemblBacteria" id="AAC65323">
        <property type="protein sequence ID" value="AAC65323"/>
        <property type="gene ID" value="TP_0337"/>
    </dbReference>
    <dbReference type="GeneID" id="57878867"/>
    <dbReference type="KEGG" id="tpa:TP_0337"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_12"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000101634" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <sequence length="285" mass="32276" checksum="3AF0BCBE16EB5D4F" modified="1998-11-01" version="1">MCCPNYNSARALAQFLTERGLRMHKKWGQNFLLDPVLRTQLVKILAPERGERVWEIGAGIGAMTALLVQNSDFLTVFEIDRGFVQTLRKLFDAHVRVIEGDVLQQWHAAAAQEQPACVLGNLPYNIAARFIGNTIESGYIFKRMVVTVQKEIGLRMTALPAQKWYSYFSVLCQWQYEVRVIRNVAPVCFWPRPHVVSQALVLTKRNAVPSCVDPALFLHVTKTLFSARRKTVRNNLLTWQKRMPGGAAVCVEELCARAGIDARARAEQLSIYDFITLSDTLRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83366</accession>
    <name>O83366_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71336">
        <property type="entry name" value="A71336"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881794.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0346"/>
    <dbReference type="EnsemblBacteria" id="AAC65337">
        <property type="protein sequence ID" value="AAC65337"/>
        <property type="gene ID" value="TP_0346"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75544">
        <property type="protein sequence ID" value="AGN75544"/>
        <property type="gene ID" value="TPANIC_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0346"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.344"/>
    <dbReference type="HOGENOM" id="CLU_1189488_0_0_12"/>
    <dbReference type="OMA" id="YGHFGIY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503420" evidence="1">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="233" mass="25341" checksum="D152921B12C240F0" modified="1998-11-01" version="1">MCMVPVRRFIAVCAVTACAGPCFCVQAFISSRIGYGRFGIYGNEIKDSYYKHVPMTGLGVDVVTSSGVAMVFNVETALTQLMFRAQALLGYAFEVGRFRFTPAIGGSFLASHDHAAGVALSLDFQYFFNDWVGLDLNIGAGVDVPVNSNLRYLMRVGTPELAKILITHTVTHGLANRWISGPHWWNSLSSWVGNTAGKVAGFVARLIANYLLKGSQYSMLVPVVVRLGAVYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83367</accession>
    <name>O83367_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71336">
        <property type="entry name" value="B71336"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881795.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65338">
        <property type="protein sequence ID" value="AAC65338"/>
        <property type="gene ID" value="TP_0347"/>
    </dbReference>
    <dbReference type="GeneID" id="57878877"/>
    <dbReference type="KEGG" id="tpa:TP_0347"/>
    <dbReference type="HOGENOM" id="CLU_1189488_0_0_12"/>
    <dbReference type="OMA" id="GWFITLA"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="276" mass="29917" checksum="12BFF3C68A7F4EF2" modified="1998-11-01" version="1">MFAWGRYTRCEGVGIRGACAEMKWSGLCLFLRTGGGGCEQMNGKRVFLGIVVVVCAARCFCADVFFSSHLGYGRFYAVGKDIEGQHMHVPSIGGGVCVVADSGFAFACTVDAALTRIMLKTQALFGYAFRWGAFSLIPLLGMDVIVSSDHAFGVAAQVSFQHLISEWWGFALSVSGGVDFPLNPNTRFLAGKLPAETVQRVALVALRQKLISEGIIKALDLGWFITFALTVVAEGFSWIVSQSAWIAQKAVNYFLSDTTRCLILPVTLRAGPTFRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83369</accession>
    <name>SLYD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>FKBP-type peptidyl-prolyl cis-trans isomerase SlyD</fullName>
            <shortName>PPIase</shortName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Metallochaperone SlyD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">slyD</name>
        <name type="ordered locus">TP_0349</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Biochemistry" volume="45" first="20" last="33">
            <title>SlyD proteins from different species exhibit high prolyl isomerase and chaperone activities.</title>
            <authorList>
                <person name="Scholz C."/>
                <person name="Eckert B."/>
                <person name="Hagn F."/>
                <person name="Schaarschmidt P."/>
                <person name="Balbach J."/>
                <person name="Schmid F.X."/>
            </authorList>
            <dbReference type="PubMed" id="16388577"/>
            <dbReference type="DOI" id="10.1021/bi051922n"/>
        </citation>
        <scope>FUNCTION AS A CHAPERONE AND A PPIASE</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal region consists of two globular folded domains that contain prolyl isomerase and chaperone activities.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal region binds nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71336">
        <property type="entry name" value="D71336"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881797.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83369"/>
    <dbReference type="SMR" id="O83369"/>
    <dbReference type="STRING" id="243276.TPANIC_0349"/>
    <dbReference type="EnsemblBacteria" id="AAC65334">
        <property type="protein sequence ID" value="AAC65334"/>
        <property type="gene ID" value="TP_0349"/>
    </dbReference>
    <dbReference type="GeneID" id="57878879"/>
    <dbReference type="KEGG" id="tpa:TP_0349"/>
    <dbReference type="eggNOG" id="COG1047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098197_1_0_12"/>
    <dbReference type="OMA" id="HSHEGGC"/>
    <dbReference type="OrthoDB" id="2044224at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000075362" description="FKBP-type peptidyl-prolyl cis-trans isomerase SlyD">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="PPIase first part" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="IF-chaperone" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="PPIase second part" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="16388577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="176" mass="18428" checksum="77F8FE1901E73399" modified="1998-11-01" version="1">MKIANECVVNIEYTLRDDTGEIIDSSDVMGALEYVQGHGMIIPGLETALINREEGEEFSVTIPPVGAYGEVQEDLRMTVGRDQFPPNVPIEVGMRFDAGSGGDSRPVTVTDVQGETIIVDGNHPLAGKTLHFEVAVRSVREATDDDLAALLFRESTSGGGCGSGAGGCGSCGAGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83382</accession>
    <name>O83382_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="5" type="ordered locus">TP_0367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71332">
        <property type="entry name" value="F71332"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881815.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83382">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0367"/>
    <dbReference type="EnsemblBacteria" id="AAC65355">
        <property type="protein sequence ID" value="AAC65355"/>
        <property type="gene ID" value="TP_0367"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75564">
        <property type="protein sequence ID" value="AGN75564"/>
        <property type="gene ID" value="TPANIC_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0367"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.367"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_1_12"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="249"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="516"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="741"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="941" mass="105926" checksum="AFBC8BE6ADA79B99" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83385</accession>
    <name>Y370_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0370</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0370</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71333">
        <property type="entry name" value="A71333"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83385"/>
    <dbReference type="IntAct" id="O83385">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0370"/>
    <dbReference type="EnsemblBacteria" id="AAC65361">
        <property type="protein sequence ID" value="AAC65361"/>
        <property type="gene ID" value="TP_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0370"/>
    <dbReference type="HOGENOM" id="CLU_153956_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202243" description="Uncharacterized protein TP_0370">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="138" mass="15998" checksum="49CC10750857745D" modified="1998-11-01" version="1">MSAQTQRLHPPFYDKRTQRVNSPFSLPAPKTQEKKYLCLLGTVDSVCAPLYDPPLAFTIPQAEVSHMNERNKLLARALYSCVPHVQGSDDYEDDFEDSDFQDGDFDDFEDEDGFDDDDDFEDDDFEYEDEDNDLDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83392</accession>
    <name>O83392_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71330">
        <property type="entry name" value="C71330"/>
    </dbReference>
    <dbReference type="IntAct" id="O83392">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65363">
        <property type="protein sequence ID" value="AAC65363"/>
        <property type="gene ID" value="TP_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0377"/>
    <dbReference type="HOGENOM" id="CLU_3278192_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="41" mass="4400" checksum="123927ACE837B3DD" modified="1998-11-01" version="1">MLCVLQCPMTEETAQRVIRALRTVAALIVCVLLLGTAGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83393</accession>
    <name>O83393_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71330">
        <property type="entry name" value="D71330"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881826.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83393">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0377"/>
    <dbReference type="EnsemblBacteria" id="AAC65364">
        <property type="protein sequence ID" value="AAC65364"/>
        <property type="gene ID" value="TP_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0378"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.400"/>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136268_1_0_12"/>
    <dbReference type="OMA" id="YTMPENE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14337" checksum="9EE5B0ADEBA323CF" modified="1998-11-01" version="1">MRTHSAPRETQTRRTTRGIAQRESAHAVYAELGRLRALSADKQPVSVIITPLLQYPAADHALYEELVQKKEQLRRASLAWCAQHTAQELHMLGPEQLKIALRDALNTQLSLGRVTHVFLEEFIILF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-04-03" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83398</accession>
    <name>MRAZ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">TP_0383</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71331">
        <property type="entry name" value="A71331"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881831.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83398"/>
    <dbReference type="SMR" id="O83398"/>
    <dbReference type="IntAct" id="O83398">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0383"/>
    <dbReference type="EnsemblBacteria" id="AAC65367">
        <property type="protein sequence ID" value="AAC65367"/>
        <property type="gene ID" value="TP_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0383"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_5_12"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000108552" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="9"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="149" mass="17096" checksum="9CA9465EC5AAE850" modified="1998-11-01" version="1">MEDNAFTGAYSYNLDEKGRLMLPARLRVALSDTRLVLTCAIESCLWVFPRAQWDRFSSQISARASLFHAPSRAVLRRLIAPAQEVELDRAWRLFIPPSLREYAALEKDCLILGLSHCLEIWDRARYRAYLAESEADFRAGTETLQDLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83412</accession>
    <name>O83412_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71328">
        <property type="entry name" value="D71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881845.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83412">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0397"/>
    <dbReference type="EnsemblBacteria" id="AAC65385">
        <property type="protein sequence ID" value="AAC65385"/>
        <property type="gene ID" value="TP_0397"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75591">
        <property type="protein sequence ID" value="AGN75591"/>
        <property type="gene ID" value="TPANIC_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0397"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.397"/>
    <dbReference type="eggNOG" id="COG1558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_12"/>
    <dbReference type="OMA" id="YVAYPNI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="6">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14145" checksum="BCF8A56E06270027" modified="1998-11-01" version="1">MISDNIANASSTRTQEGGVFRRSRVVLAQKNPGIDWRIPFVPEQLDRGVGTGVRVVSIEKDNAPSRLVYDPTHPDAILSGPKAGYVEYPNVDIVTEMVDLISASRAYEANISVISGSKEMFQRALEIAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83414</accession>
    <name>FLIF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliF</name>
        <name type="ordered locus">TP_0399</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71328">
        <property type="entry name" value="F71328"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881847.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83414"/>
    <dbReference type="SMR" id="O83414"/>
    <dbReference type="IntAct" id="O83414">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0399"/>
    <dbReference type="PRIDE" id="O83414"/>
    <dbReference type="EnsemblBacteria" id="AAC65387">
        <property type="protein sequence ID" value="AAC65387"/>
        <property type="gene ID" value="TP_0399"/>
    </dbReference>
    <dbReference type="GeneID" id="57878925"/>
    <dbReference type="KEGG" id="tpa:TP_0399"/>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028108_2_0_12"/>
    <dbReference type="OMA" id="NYEVNRI"/>
    <dbReference type="OrthoDB" id="167675at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000180887" description="Flagellar M-ring protein">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="567" mass="64639" checksum="16344A3FB94281EE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83421</accession>
    <name>MURI_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate racemase</fullName>
            <ecNumber evidence="1">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murI</name>
        <name type="ordered locus">TP_0406</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71329">
        <property type="entry name" value="E71329"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881854.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83421"/>
    <dbReference type="SMR" id="O83421"/>
    <dbReference type="STRING" id="243276.TPANIC_0406"/>
    <dbReference type="EnsemblBacteria" id="AAC65392">
        <property type="protein sequence ID" value="AAC65392"/>
        <property type="gene ID" value="TP_0406"/>
    </dbReference>
    <dbReference type="GeneID" id="57878932"/>
    <dbReference type="KEGG" id="tpa:TP_0406"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_2_2_12"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000095529" description="Glutamate racemase">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <sequence length="268" mass="29449" checksum="AC224098FC8928E0" modified="1998-11-01" version="1">MSDRREQFQYAFLDSGIGGLPYAHALRVRVPEASLVYVADRVYFPYGNKSSAQIIARASAVLQKVQTNFSPHIVVLACNSMSVNALEFLRAQVSVPVVGVVPAIKQAVACSHKKHIGVLATQCTITHPYTACLRAQFGAGCVFQMRADARLIECLERGLIFEVEDMQREAVARSVMPFQEAGVDVLVLACTHFVHVRHLFQDCVGTSCTVVDSLEGVVRRTLRLCPPQSQLRGNAACYVTGARDAVCAARYARYAQHFGLRWAGFLDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83439</accession>
    <name>VATE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpE</name>
        <name type="ordered locus">TP_0424</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71325">
        <property type="entry name" value="E71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881872.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83439"/>
    <dbReference type="SMR" id="O83439"/>
    <dbReference type="IntAct" id="O83439">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0424"/>
    <dbReference type="EnsemblBacteria" id="AAC65411">
        <property type="protein sequence ID" value="AAC65411"/>
        <property type="gene ID" value="TP_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0424"/>
    <dbReference type="eggNOG" id="COG1390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194461_0_0_12"/>
    <dbReference type="OMA" id="MQFEVKD"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000117335" description="V-type ATP synthase subunit E">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="232" mass="24977" checksum="CA8184EC3B642D1E" modified="1998-11-01" version="1">MLGESREEAERIVRAAREEAERIVRAAREEAERIESSSLAALSQASRNVLLSFQDSVTRSLRAIISMETAQAYDAGVLRELIPRVVSAWVQAEGDKLELILSPADLRTLEGVFCAALQEQLSAGVELRSDDCLTAGFRIVPAEGGSYYDFSAAAVAQLFSSYVSARVAEVLSLLRRSCDVFLLLPYNAATISSMRRGASFALSGFFGLCATFLGSAGCCGAWKYLVVSRAGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83440</accession>
    <name>Y425_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0425</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0425</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71325">
        <property type="entry name" value="F71325"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83440"/>
    <dbReference type="STRING" id="243276.TPANIC_0425"/>
    <dbReference type="EnsemblBacteria" id="AAC65419">
        <property type="protein sequence ID" value="AAC65419"/>
        <property type="gene ID" value="TP_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0425"/>
    <dbReference type="HOGENOM" id="CLU_2496941_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202253" description="Uncharacterized protein TP_0425">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <sequence length="86" mass="9737" checksum="728CDB709B7132DB" modified="1998-11-01" version="1">MCPVPARDSTGSRVLDRWGEFEYALRCALARERADRLRWDTPVEVRQCPVAQESVARAARVAVSLDDPLEAGVFFERRALFLCRGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83441</accession>
    <name>VATA1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase alpha chain 1</fullName>
            <ecNumber>7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit A 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpA1</name>
        <name type="ordered locus">TP_0426</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71325">
        <property type="entry name" value="G71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881874.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83441"/>
    <dbReference type="SMR" id="O83441"/>
    <dbReference type="STRING" id="243276.TPANIC_0426"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65412">
        <property type="protein sequence ID" value="AAC65412"/>
        <property type="gene ID" value="TP_0426"/>
    </dbReference>
    <dbReference type="GeneID" id="57878951"/>
    <dbReference type="KEGG" id="tpa:TP_0426"/>
    <dbReference type="eggNOG" id="COG1155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_1_1_12"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144620" description="V-type ATP synthase alpha chain 1">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="589" mass="65019" checksum="F890967333DAB14E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83446</accession>
    <name>COAX_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type III pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaX</name>
        <name type="ordered locus">TP_0431</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71326">
        <property type="entry name" value="D71326"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881879.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83446"/>
    <dbReference type="SMR" id="O83446"/>
    <dbReference type="STRING" id="243276.TPANIC_0431"/>
    <dbReference type="EnsemblBacteria" id="AAC65417">
        <property type="protein sequence ID" value="AAC65417"/>
        <property type="gene ID" value="TP_0431"/>
    </dbReference>
    <dbReference type="GeneID" id="57878956"/>
    <dbReference type="KEGG" id="tpa:TP_0431"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_1_12"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000267602" description="Type III pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="5"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <sequence length="273" mass="28472" checksum="439C9C77CB598BC0" modified="1998-11-01" version="1">MLLIDVGNSHVVFGIQGENGGRVCVRELFRLAPDARKTQDEYSLLIHALCERAGVGRASLRDAFISSVVPVLTKTIADAVAQISGVQPVVFGPWAYEHLPVRIPEPVRAEIGTDLVANAVAAYVHFRSACVVVDCGTALTFTAVDGTGLIQGVAIAPGLRTAVQSLHTGTAQLPLVPLALPDSVLGKDTTHAVQAGVVRGTLFVIRAMIAQCQKELGCRCAAVITGGLSRLFSSEVDFPPIDAQLTLSGLAHIARLVPTSLLPPATVSGSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83449</accession>
    <name>O83449_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71326">
        <property type="entry name" value="G71326"/>
    </dbReference>
    <dbReference type="IntAct" id="O83449">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65422">
        <property type="protein sequence ID" value="AAC65422"/>
        <property type="gene ID" value="TP_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0434"/>
    <dbReference type="HOGENOM" id="CLU_1219263_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25035" checksum="3FA02711A86E45FE" modified="1998-11-01" version="1">MREGSVRWRTCRRYVEPASEREGGEREGGGLPKVVEPASEREGGEREVEDVPGVVEPASGHEGGEREVEDVPGVVEPASGHEGGEREVASQHTKQPSHSVSNSAPNQFRNPEGELPFTLPDLSESEIVVPEEQKGRAHPQVIPEGAPRGLQPGEYYVQIAVFHDAIQVQSIVHRYGVEYPIAVEQDIHEGKVRFTVCVGPVQKDERGAVLENFQRFGFKDAFLKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83458</accession>
    <name>O83458_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71324">
        <property type="entry name" value="D71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881892.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0444"/>
    <dbReference type="EnsemblBacteria" id="AAC65431">
        <property type="protein sequence ID" value="AAC65431"/>
        <property type="gene ID" value="TP_0444"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75637">
        <property type="protein sequence ID" value="AGN75637"/>
        <property type="gene ID" value="TPANIC_0444"/>
    </dbReference>
    <dbReference type="GeneID" id="57878968"/>
    <dbReference type="KEGG" id="tpa:TP_0444"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.442"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_3_12"/>
    <dbReference type="OMA" id="ANGYKGP"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="111"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="342" mass="36588" checksum="ADC98C327E167CA2" modified="1998-11-01" version="1">MRAPAGCGVSRLRVNVCYLRQGERARIGDAHAFFLSAEKGAGMGGFFLSLAGCFLLAAAYGAAQTVHVIAKGETLFSLSRRYGVPLSALAQANNLANVHQLVPGQRIVVPRGYTVRRGDTLFSIARMLNCSLAALLAANGISAAHTIHPGDVLVIPPREKSPPTVAGADRILSVSSLPDGDQWARARADPVQTPVSPPAAVPAPERREISLRDPRQYISKKVDKNARWPVSPTSLAYVRGKTYGVVIDSERNAAVRALMSGKVISRGTHRGYGQVLFVESAGKHVYVYGGLERILPKSGDYVSAGDVLGNLGFDAAAARSRLYFMVYKKNKPIDPAQAPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83470</accession>
    <name>O83470_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71323">
        <property type="entry name" value="B71323"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881906.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83470">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0457"/>
    <dbReference type="EnsemblBacteria" id="AAC65441">
        <property type="protein sequence ID" value="AAC65441"/>
        <property type="gene ID" value="TP_0457"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75651">
        <property type="protein sequence ID" value="AGN75651"/>
        <property type="gene ID" value="TPANIC_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0457"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.457"/>
    <dbReference type="eggNOG" id="ENOG5033X70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041913_0_0_12"/>
    <dbReference type="OMA" id="GLDWTRN"/>
    <dbReference type="OrthoDB" id="1036884at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="593" mass="65567" checksum="C689136D1516548F" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83471</accession>
    <name>O83471_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71320">
        <property type="entry name" value="D71320"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881907.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83471">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0458"/>
    <dbReference type="EnsemblBacteria" id="AAC65446">
        <property type="protein sequence ID" value="AAC65446"/>
        <property type="gene ID" value="TP_0458"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75652">
        <property type="protein sequence ID" value="AGN75652"/>
        <property type="gene ID" value="TPANIC_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0458"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.458"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_12"/>
    <dbReference type="OMA" id="HHTASGY"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="192" mass="20776" checksum="23F008F1C8BF3894" modified="1998-11-01" version="1">MDQAEPCTLHGAPAPDLALLEAILFVEGVRLSYACLARKLGLSEQAVGECVARLGEALASGARGGGGLELHCNEQGVALLPAATVRERLATLYGKRSEGRLSRAAMETLSIVAYAQPVTRAEIEAIRGVGADTMIRLLSERRLICEVGKKDIPGKPAQYGTTEEFLTAFRLRSIADLPKLDEEEQRRFELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83473</accession>
    <name>O83473_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71320">
        <property type="entry name" value="F71320"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881909.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0460"/>
    <dbReference type="EnsemblBacteria" id="AAC65453">
        <property type="protein sequence ID" value="AAC65453"/>
        <property type="gene ID" value="TP_0460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75654">
        <property type="protein sequence ID" value="AGN75654"/>
        <property type="gene ID" value="TPANIC_0460"/>
    </dbReference>
    <dbReference type="GeneID" id="57878984"/>
    <dbReference type="KEGG" id="tpa:TP_0460"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.460"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_14_0_12"/>
    <dbReference type="OMA" id="CYDEAIR"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="235" mass="25958" checksum="5D22EE9D060F421B" modified="1998-11-01" version="1">MGCARCSYFAGAAGILRAHTRSRRGGGRLVNQFFEEFECPEHGRQPRGVQETAESLNCLALSCARKGWYEETVACLRKGLGLSPFNGLLWLNLALGYYALKRTVDSAGALYHALRCTPHHAAVWNMLGVVLHDMGDTEASRNAYEHAIRLETKNGATWNNYGLLLHTEQKYDQAQRAFETALSLLPRSGSALYNLSRTYHALGDARKAAVCRRILAQMPAGEKKPGPITPFALHP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83503</accession>
    <name>O83503_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71318">
        <property type="entry name" value="B71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881939.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83503">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0490"/>
    <dbReference type="EnsemblBacteria" id="AAC65477">
        <property type="protein sequence ID" value="AAC65477"/>
        <property type="gene ID" value="TP_0490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75681">
        <property type="protein sequence ID" value="AGN75681"/>
        <property type="gene ID" value="TPANIC_0490"/>
    </dbReference>
    <dbReference type="GeneID" id="57879012"/>
    <dbReference type="KEGG" id="tpa:TP_0490"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.487"/>
    <dbReference type="HOGENOM" id="CLU_206695_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="62" mass="7230" checksum="6BD1E040146CFAD8" modified="1998-11-01" version="1">MSEEERMYSFSGEEIKELALLFRRCGQTLAPALRRLALFVDRTVCRHMTVEEAEDFFGSAER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83515</accession>
    <name>Y502_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative ankyrin repeat-containing protein TP_0502</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0502</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71317">
        <property type="entry name" value="B71317"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881951.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83515"/>
    <dbReference type="SMR" id="O83515"/>
    <dbReference type="STRING" id="243276.TPANIC_0502"/>
    <dbReference type="EnsemblBacteria" id="AAC65491">
        <property type="protein sequence ID" value="AAC65491"/>
        <property type="gene ID" value="TP_0502"/>
    </dbReference>
    <dbReference type="GeneID" id="57879023"/>
    <dbReference type="KEGG" id="tpa:TP_0502"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077687_0_0_12"/>
    <dbReference type="OMA" id="KEREYDF"/>
    <dbReference type="OrthoDB" id="1691070at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0040">ANK repeat</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000067242" description="Putative ankyrin repeat-containing protein TP_0502">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 1">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 2">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 3">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 4">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <sequence length="298" mass="32803" checksum="DD3C2E925C6BA2B0" modified="1998-11-01" version="1">MKVVLFYDQGRAHSVAAICEVLCAQGCAVTPHAIEQVWNDTSPCSTPLALVQDATHVFFLYAHEPMRDPAFIFFSGVACGRGMHVLLLATTTEVRDIHVFRDLVFLLEEETFEDFFRVEHERFVRQKKKRVARTALLERGYPCFEENFIATVMDGNIDIVNLFLDAGFSAALKDARGTPVLSLAVREGQDEMAAQLIARGAPVDQLSDDRAYSALMEAAQIGNRTVARLLLHAGADPNVRGSNGQTALVLAVGRKDHVLIRLLMDHGANPYLEDKLGLSAQGYAKLFNDPTLCTLVGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83544</accession>
    <name>VATI2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit I 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit I 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpI2</name>
        <name type="ordered locus">TP_0533</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71313">
        <property type="entry name" value="F71313"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881980.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83544"/>
    <dbReference type="SMR" id="O83544"/>
    <dbReference type="IntAct" id="O83544">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0533"/>
    <dbReference type="EnsemblBacteria" id="AAC65519">
        <property type="protein sequence ID" value="AAC65519"/>
        <property type="gene ID" value="TP_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0533"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602593_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000119243" description="V-type ATP synthase subunit I 2">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="454" mass="50847" checksum="E96C1E95A9C1BD33" modified="1998-11-01" version="1">MFRSQRMKFLELVVLERDVDRVLEYLGKTALVHLRLSAAARGSSSHCAQSKEYVGRLEEACKYLGVSGECAFSPGDSLPTEEDYTLAQQILAEVDALHAREREGDAPSVPRGKSSVAHDSANEEQFQGEKCALGSMRGPALCALLRRFALQERVHRTRDALESTRHTYRIAGWLPAHEAKDLVAGLDNVTTGRMAVRLFEPQELSFIRDGSEHVPVCYQHGRFVRSYERMVSSYGCPPYGLVDPTPFVAFSYALLFGIMFGDLGQGLLFFVLGLLLRTRRVRALNRWAHLDYVFLSVGFSSMVMGFLTGEFFAHGTLLAPLIRSVTALCGGVPRDHILHLMPSHGSLHTLMAFFGFTLFLGFVINSLGLIINIVNQVRLRHALQQCVQKRECADSSFFGTWLPLQCAYHFLEFHSGSLMRLQWACLSWVFFVKSFWSVCASVCVRGFLKVLACI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83545</accession>
    <name>Y534_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0534</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0534</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71313">
        <property type="entry name" value="G71313"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881981.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83545"/>
    <dbReference type="SMR" id="O83545"/>
    <dbReference type="STRING" id="243276.TPANIC_0534"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65520">
        <property type="protein sequence ID" value="AAC65520"/>
        <property type="gene ID" value="TP_0534"/>
    </dbReference>
    <dbReference type="GeneID" id="57879058"/>
    <dbReference type="KEGG" id="tpa:TP_0534"/>
    <dbReference type="eggNOG" id="COG1527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823713_0_0_12"/>
    <dbReference type="OMA" id="RSYEYAD"/>
    <dbReference type="OrthoDB" id="1312963at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202270" description="Uncharacterized protein TP_0534">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <sequence length="341" mass="38992" checksum="A65958A20E03BC4B" modified="1998-11-01" version="1">MAVERDVADVFVYAKLSGLCARLWVGERLGTLQGVGTLCDLWVRLFSEPAPRSAGAHLVGLIQRRVEACLLRDCVRAASCYQEPPSLFSALLARYDYLYLKTLSSSESQAGFRVCQPPDLGRFSLFRWEKWPCIEAVTRGSPVSWYNRVPRSDERVLWDLRLDQSYYHALWQTLCSIPEDDRTACSRLVREEVALYAVGWVLRLRMFYGVQKKDAPSELSSNGAIRRCLGTWWKCILFAWDCSLTERGAWSGWRYERFLNNPVDGVQWEPDLDAFERAGSRFLYCLARTVFHAQLFTPATIVAFFMMKRFEARGICALAECIHAGSARTLPREFLGEAAYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83549</accession>
    <name>PGK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoglycerate kinase</fullName>
            <ecNumber>2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">pgk</name>
        <name type="ordered locus">TP_0538</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71311">
        <property type="entry name" value="G71311"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83549"/>
    <dbReference type="SMR" id="O83549"/>
    <dbReference type="IntAct" id="O83549">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0538"/>
    <dbReference type="EnsemblBacteria" id="AAC65523">
        <property type="protein sequence ID" value="AAC65523"/>
        <property type="gene ID" value="TP_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0538"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_12"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000146030" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="419" mass="44944" checksum="7A8C5CACA906342D" modified="1998-11-01" version="1">MMLRTCKDVTMRGERVVVRVDFNVPMRDGMVQDDTRVTAAVPTLRYIIEQGPRHVVLISHLGDPTRDADKAEGNAKKDGCPFDRHAFINGKHRLKPVADCLAKKLGVPVHFAPSCVGQREFIEGLPDGSVVLLENVRFHPEETSGDAKVQEQFARELAQYGDIFVNDAFGTAHREHASTVVLPRLMRRRVAGLLIEREVRYLEPMVCNPKVPMVAVVGGAKVSSKIAVLESLLRTSTALIIGGGMAYTFLKAQGVGVGTSLVEDDFIDTARMLLQKAQSGGVSVVLPVDHVCASTFCADAQPVAVDDVHIPMHLMGMDVGPRTLEQYRAHLKGVSSVLWNGPVGVFEFDAFAHGTRVLAQLIAEATDAGATSVVGGGDSIAAVSKFGLASRMSHVSTGGGASLKLFEGKVLPGISCLET</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83577</accession>
    <name>O83577_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alginate O-acetylation protein (AlgI)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TP_0566</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71308">
        <property type="entry name" value="D71308"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882013.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0566"/>
    <dbReference type="EnsemblBacteria" id="AAC65540">
        <property type="protein sequence ID" value="AAC65540"/>
        <property type="gene ID" value="TP_0566"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75753">
        <property type="protein sequence ID" value="AGN75753"/>
        <property type="gene ID" value="TPANIC_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0566"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.562"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_4_1_12"/>
    <dbReference type="OMA" id="IIWGAWH"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="495" mass="56857" checksum="5B3B0ED9C77EBDD7" modified="1998-11-01" version="1">MFFSLLSPAAFLFIFFILYWYVFRTATQRVVVLLVANFLAIAAFDIRFCIPYLVLSALAYSCGLLILMQKSFLWRKVLLIAGTLLQILFFCLFKHFSDMLSLVRAFAPAYFAQHTWHQHVKDWNIWHPVGISYCTFKCMSYVFDVYLCKIRRREPFARVLLYVSFFPQMISGPIANASHFFTRLPHNLRAGESPLDRPIHFDRAVVLLYTGLVKKVIFADFLSILVTDKIFTLPSAYSSTELLFGLISYSAVLYCDFSGYSDLAIAVGLLFGFETPANFKRPYISQSVTEFWRRWHISFSQWLKEYLYFSLGGSRFGIKRTVCALFFTMLIAGLWHGVRLTFLLWGMAQGVALVIERVYREKRRVNGANAFGSSSVMGRWKARAMRCIRVSALFLFVSVGWLIFRAPSFAEVWRYVTLLFRGSWHGPFQVITPFTALLALCALCVQLPSDRTRARAFACYCAVPLPVKALCAAFFFFVLSVMTPSGIAPFIYYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83579</accession>
    <name>O83579_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71308">
        <property type="entry name" value="G71308"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882016.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83579">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0569"/>
    <dbReference type="EnsemblBacteria" id="AAC65543">
        <property type="protein sequence ID" value="AAC65543"/>
        <property type="gene ID" value="TP_0569"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75756">
        <property type="protein sequence ID" value="AGN75756"/>
        <property type="gene ID" value="TPANIC_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0569"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.565"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_1_12"/>
    <dbReference type="OMA" id="YRPGKWG"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="429"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="5">
        <location>
            <begin position="715"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="774" mass="83723" checksum="1ABAC7A88CAB7448" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83586</accession>
    <name>Y577_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0577</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0577</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71306">
        <property type="entry name" value="G71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882023.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83586"/>
    <dbReference type="STRING" id="243276.TPANIC_0577"/>
    <dbReference type="EnsemblBacteria" id="AAC65558">
        <property type="protein sequence ID" value="AAC65558"/>
        <property type="gene ID" value="TP_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0577"/>
    <dbReference type="eggNOG" id="ENOG5032HA5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444757_0_0_12"/>
    <dbReference type="OMA" id="TMSENAD"/>
    <dbReference type="OrthoDB" id="776672at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202277" description="Uncharacterized protein TP_0577">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="614" mass="68121" checksum="1A748160AA5F8F8D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O83587</accession>
    <name>O83587_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein (FtsY)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71306">
        <property type="entry name" value="H71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882024.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83587">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0578"/>
    <dbReference type="EnsemblBacteria" id="AAC65553">
        <property type="protein sequence ID" value="AAC65553"/>
        <property type="gene ID" value="TP_0578"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75764">
        <property type="protein sequence ID" value="AGN75764"/>
        <property type="gene ID" value="TPANIC_0578"/>
    </dbReference>
    <dbReference type="GeneID" id="57879101"/>
    <dbReference type="KEGG" id="tpa:TP_0578"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.574"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_12"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="295" mass="31928" checksum="7203F8413AA9CD99" modified="1998-11-01" version="1">MKVGLGNLAQKIRRLLGGQAPLDETFFSALEELLIEGDLSLSTAESFCTQLRNAARTRSVHTEDALRTLFAEIMESCVRVTHLAPNPNQCSLYLLLGVNGSGKTTSAAKLAAYYQTQKVHPILFAAADTFRAAAAEQLAHHGAQLGVRVIAHPGGKDPAAVVFDAGEALRAQKRGLLLVDTAGRLHNKTHLIAELQKIDRIAQTKVSADAYRKILVLDATTGQNAFRQAQTFHEAIGVDALLLAKCDTRARGGAVFSIMQELGIPLAFLGWGERYTDLVEANAREFVSSFLHGER</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83589</accession>
    <name>O83589_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71307">
        <property type="entry name" value="B71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882026.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83589">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0580"/>
    <dbReference type="EnsemblBacteria" id="AAC65554">
        <property type="protein sequence ID" value="AAC65554"/>
        <property type="gene ID" value="TP_0580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75766">
        <property type="protein sequence ID" value="AGN75766"/>
        <property type="gene ID" value="TPANIC_0580"/>
    </dbReference>
    <dbReference type="GeneID" id="57879103"/>
    <dbReference type="KEGG" id="tpa:TP_0580"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.576"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_12"/>
    <dbReference type="OMA" id="GWWQQNG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="297"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="429" mass="47955" checksum="5F6DAB63F338597A" modified="1998-11-01" version="1">MSNTHVQTLRWMCFMVRRLNSVRARSANAITSLFFILGIAFGALTLIVILSVMNGFQQGFIGTILQVSSAHVRVYGSVDAVKRAETLGGYQSFYPFIEAHALLQGNYYRQHGALVRAVPADIFHRDRLLARALPITSGSFNLSKKHSIVLGYELARHLSVRTGDQVDTLALSGSDTQKIMPGWNKLTVTGIFKSGYHEVDSTFAYIPLDMGTTLFGTTPDITAAVKLNNHERDDRYLFFLAQHIPDLKAESWREYNRAFFSALRIEKNVMILLVILIFMVVTVNIYHSMRRSIRTRKEEIAMLVSLGAPVSHVQILFIGNGIMIGFLGSLLGVLLGLLITIHVNEIIACIETAVNSAFFLFSLFSGTKTPSFSVFGTQYFYNVERIPVQIFFQEVLFVFLFGTGSASVATYLATRKILLLKPAEVLRDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83590</accession>
    <name>LOLD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lolD</name>
        <name type="ordered locus">TP_0581</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71307">
        <property type="entry name" value="C71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882027.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83590"/>
    <dbReference type="SMR" id="O83590"/>
    <dbReference type="STRING" id="243276.TPANIC_0581"/>
    <dbReference type="EnsemblBacteria" id="AAC65555">
        <property type="protein sequence ID" value="AAC65555"/>
        <property type="gene ID" value="TP_0581"/>
    </dbReference>
    <dbReference type="GeneID" id="57879104"/>
    <dbReference type="KEGG" id="tpa:TP_0581"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51244">
        <property type="entry name" value="LOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092462" description="Lipoprotein-releasing system ATP-binding protein LolD">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01708"/>
        </source>
    </evidence>
    <sequence length="226" mass="25299" checksum="2EBA1B962BEF70E3" modified="1998-11-01" version="1">MNDPILSVEQVSKSFCCATERIQILSDVSFSVPRAVKVAITGESGCGKSTLLNIIGGMEHADSGIVRVLSCDVLTLHEHALTEYRRQFLGLVFQFHHLLRDFTALENVMLPGLIAGKSYREVRARAYELLEKVRVVQRAHHFPAQMSGGERQRTAVARALINDPTLILADEPTGNLDPKNALIVQDLLFSLTEEYQKTLLIVTHDPRIASMTDYRYQLQQGSLIRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83595</accession>
    <name>SYL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">TP_0586</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71305">
        <property type="entry name" value="C71305"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882032.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83595"/>
    <dbReference type="SMR" id="O83595"/>
    <dbReference type="IntAct" id="O83595">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0586"/>
    <dbReference type="EnsemblBacteria" id="AAC65562">
        <property type="protein sequence ID" value="AAC65562"/>
        <property type="gene ID" value="TP_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0586"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_12"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152109" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="634"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="878" mass="98991" checksum="DCD74E2DC3652B74" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83610</accession>
    <name>DXR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="1">DXP reductoisomerase</shortName>
            <ecNumber evidence="1">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxr</name>
        <name type="ordered locus">TP_0601</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DXR family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65574" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65574.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71304">
        <property type="entry name" value="C71304"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013945233.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83610"/>
    <dbReference type="SMR" id="O83610"/>
    <dbReference type="STRING" id="243276.TPANIC_0601"/>
    <dbReference type="EnsemblBacteria" id="AAC65574">
        <property type="protein sequence ID" value="AAC65574"/>
        <property type="gene ID" value="TP_0601"/>
    </dbReference>
    <dbReference type="GeneID" id="57879124"/>
    <dbReference type="KEGG" id="tpa:TP_0601"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_12"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000163727" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="376" mass="40952" checksum="CED7DD6DDB5F507F" modified="2000-05-30" version="2">MSVRRVVVLGITGSIGAAALKLLRRFPDRFLLVGASGHRQTEYARALAREFSLSDITMTGSCSEQEGRARIKRLLSSCEAEVVVNGIAGAAGLFASLEVLKTRCTLALANKESVVLAASLLHAAARESGATIVPVDSEHAAIFQLIAAHGAHAVAQVVLTASGGPFRTFSKECLAHVTVEDALQHPTWRMGKKISVDSATLANKALEVIEAVQFFRIPVDRVTVVVHPQSIVHALVQCHSGETYAQLSVPDMASPLLYALLYPDAPPAYQTPLDFTSGLSLHFEPPRVDDFPLLRMGFDVARAQRAYPIAFNAANEEAVRAFLQRNIGFLDIAHVTAQALQEDWRAIPQTFEEVMACDTRARMCARTCIAQRWRER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83615</accession>
    <name>RS2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsB</name>
        <name type="ordered locus">TP_0606</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71304">
        <property type="entry name" value="H71304"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882052.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83615"/>
    <dbReference type="SMR" id="O83615"/>
    <dbReference type="STRING" id="243276.TPANIC_0606"/>
    <dbReference type="EnsemblBacteria" id="AAC65579">
        <property type="protein sequence ID" value="AAC65579"/>
        <property type="gene ID" value="TP_0606"/>
    </dbReference>
    <dbReference type="GeneID" id="57879129"/>
    <dbReference type="KEGG" id="tpa:TP_0606"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_3_12"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000134267" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="291" mass="33117" checksum="5212538AF1BFBCC1" modified="1998-11-01" version="1">MAVVTIKNLLESGVHFGHQVRRWDPRMKKYIFAERNGIHIIDLQKTITAIREAYDMVRRTVSSGKSVLFVGTKKQSQQTIAKEAQRCGMFYVTNRWLGGMLTNFSTIRKSLSRLKKIERMEIDGTFEHLSKKEVASLRKEHAKLEKNLGGIKEMKELPGVVFIIDTRKETIAIREARRVGIPIVAVVDTNCNPEGIDYPIPGNDDAIRAISLFTQLIANAVMEAGNEHGLKIIENLQDEESGDELDESVSLHEEGREITDYENYTPPEEREYSVNDEGDVFDEDESLYEGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83617</accession>
    <name>Y608_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0608</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0608</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71305">
        <property type="entry name" value="B71305"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83617"/>
    <dbReference type="STRING" id="243276.TPANIC_0608"/>
    <dbReference type="EnsemblBacteria" id="AAC65584">
        <property type="protein sequence ID" value="AAC65584"/>
        <property type="gene ID" value="TP_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0608"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081869_0_0_12"/>
    <dbReference type="OMA" id="VEESYLQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202287" description="Uncharacterized protein TP_0608">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="296" mass="31910" checksum="D0C07235FA48DEFC" modified="1998-11-01" version="1">MADPSACVFRSLRIPGHKPLTWCAKCSTMCPRVPCGSVSVPCAFCTISFRRKCPMQQRFFLLGVCAFAFGVPVFPQQGTDPSVGAQASAGDGGMMTVEQAYLNSAEGVVIKEMVESRGHDSKVLALQYIQEALEGGRGSDDLQEALSRLATAGLFRVIREQGRVINDFPDIRLRACELLARLPSARTKDALIQVMCADREPSVVRAAVKSLGEVGINEQDETTATIGWISRKFSAINPTGSLALEILNTYERLAPTVRDRRAVVESIMDIAADGRYAAAVRARALEVVKGVVSGGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O83642</accession>
    <name>DNLJ_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="synonym">lig</name>
        <name type="ordered locus">TP_0634</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71300">
        <property type="entry name" value="H71300"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882080.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83642"/>
    <dbReference type="SMR" id="O83642"/>
    <dbReference type="IntAct" id="O83642">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0634"/>
    <dbReference type="EnsemblBacteria" id="AAC65609">
        <property type="protein sequence ID" value="AAC65609"/>
        <property type="gene ID" value="TP_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="57879157"/>
    <dbReference type="KEGG" id="tpa:TP_0634"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_3_12"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000161774" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 1" evidence="1">
        <location>
            <begin position="562"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 2" evidence="1">
        <location>
            <begin position="654"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 3" evidence="1">
        <location>
            <begin position="741"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="823" mass="91098" checksum="1EFC9DBC57532A6B" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83644</accession>
    <name>MIAA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">TP_0637</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71301">
        <property type="entry name" value="B71301"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882082.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83644"/>
    <dbReference type="SMR" id="O83644"/>
    <dbReference type="IntAct" id="O83644">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0637"/>
    <dbReference type="PRIDE" id="O83644"/>
    <dbReference type="EnsemblBacteria" id="AAC65611">
        <property type="protein sequence ID" value="AAC65611"/>
        <property type="gene ID" value="TP_0637"/>
    </dbReference>
    <dbReference type="GeneID" id="57879159"/>
    <dbReference type="KEGG" id="tpa:TP_0637"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_12"/>
    <dbReference type="OMA" id="LEIAIHQ"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000164001" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="316" mass="36174" checksum="E4BE144EE6ED5208" modified="1998-11-01" version="1">MRLETQALVPYPVRFDRSHHDALVVLGATATGKTALAVALAQKYQGEIISADSRQVYRGLDVGTGKDLALYGSVPYHLIDVCDPYEEYNVFRFQQAVYGIVPSILRAHKVPIIVGGTGLYLDAVLRQYALVPVERNQALRASLRGASLSHMRAVYFSLKDSHAVHNKTDLEDPARLMRAIEIAVFHATHPELLQQARETRPMMRAKVYGIQYPRSMLRARIRARLEQRIRGGLIEEVAALHKGGVSWQRLEYFGLEYRFTAQYLQGIIATRDEYVDLLFRAISRFAKRQETWFRRMQRLGVKIHWLVHTENGFVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83666</accession>
    <name>O83666_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71297">
        <property type="entry name" value="E71297"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882105.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83666">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0660"/>
    <dbReference type="EnsemblBacteria" id="AAC65634">
        <property type="protein sequence ID" value="AAC65634"/>
        <property type="gene ID" value="TP_0660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75838">
        <property type="protein sequence ID" value="AGN75838"/>
        <property type="gene ID" value="TPANIC_0660"/>
    </dbReference>
    <dbReference type="GeneID" id="57879183"/>
    <dbReference type="KEGG" id="tpa:TP_0660"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.652"/>
    <dbReference type="eggNOG" id="COG1256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012762_1_1_12"/>
    <dbReference type="OMA" id="KPQAAYM"/>
    <dbReference type="OrthoDB" id="1815809at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="576"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="625" mass="68562" checksum="2BE47A5D91C8C2FA" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83674</accession>
    <name>O83674_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71295">
        <property type="entry name" value="G71295"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882113.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83674">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0668"/>
    <dbReference type="EnsemblBacteria" id="AAC26566">
        <property type="protein sequence ID" value="AAC26566"/>
        <property type="gene ID" value="TP_0668"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75846">
        <property type="protein sequence ID" value="AGN75846"/>
        <property type="gene ID" value="TPANIC_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0668"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.660"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113320_0_0_12"/>
    <dbReference type="OMA" id="FFRFGIY"/>
    <dbReference type="OrthoDB" id="1981182at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC26566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="202" mass="22693" checksum="4628F8BDAF12AFF1" modified="1998-11-01" version="1">MSSVLSTLSALLSVYALLCTARVFLSWVPHLSHSPLGEFLSAICEPYLSWFRRFSFMRVGTVDFSPMIAIGVLTILSNTVGTIFLVGSVSVLKLLLQMLMLLLLLWSLCKFVLEFLLILFAVRFVSDRMNVNVHTLFFVMMDRILNPVRVALTAPFKFLDLSYRASLLLCVLVILCARVLGGFFVNVVVRYFLTGTLHVAVM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83676</accession>
    <name>DDL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="2">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ddl</name>
        <name type="synonym">ddlA</name>
        <name type="ordered locus">TP_0670</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71296">
        <property type="entry name" value="A71296"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882115.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83676"/>
    <dbReference type="SMR" id="O83676"/>
    <dbReference type="IntAct" id="O83676">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0670"/>
    <dbReference type="EnsemblBacteria" id="AAC26568">
        <property type="protein sequence ID" value="AAC26568"/>
        <property type="gene ID" value="TP_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0670"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_12"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177898" description="D-alanine--D-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="141"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="396" mass="42728" checksum="FB5829335B6111A5" modified="1998-11-01" version="1">MVHVTLLYGGRSAEHDVSVRSARFVARTLCLQHTVMLIGITRRGVWYAQPACALEQLCTGTVALSIQEDEKRRVCLVPGGGTAGAFVIAGMPCVTDVVFPVLHGSYGEDGTVQGLLEMLQVPYVGCGVCASALAMDKVKAKMLWQAAGLPVLPFVFFRKDAWRMHMQEFVAQLETRLGYPLFVKPAQAGSSVGASAVQTRAPLIPAIEAAFQWDEVVLVERYVRAREIECALSGNGPYTVHGAGEVIAQGAFYDYEEKYADASVARVLVTAPLETAQYEQITTLALRAYEALGLTGLARVDFFLLETGEVYVNEVNTMPGFTSISLFPQICQAAGVAPQDLMAQLLSCARERFAARAALSTDLHAHVCAPSVTAAHDPDAQGDDWDQRDSNPLPTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O83679</accession>
    <name>SYE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">TP_0673</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71296">
        <property type="entry name" value="D71296"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882118.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83679"/>
    <dbReference type="SMR" id="O83679"/>
    <dbReference type="IntAct" id="O83679">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0673"/>
    <dbReference type="EnsemblBacteria" id="AAC26571">
        <property type="protein sequence ID" value="AAC26571"/>
        <property type="gene ID" value="TP_0673"/>
    </dbReference>
    <dbReference type="GeneID" id="57879197"/>
    <dbReference type="KEGG" id="tpa:TP_0673"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_12"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000119687" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="537" mass="59840" checksum="BD9D58C627BAE37F" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83687</accession>
    <name>RLME_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="1">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmE</name>
        <name evidence="1" type="synonym">ftsJ</name>
        <name evidence="1" type="synonym">rrmJ</name>
        <name type="ordered locus">TP_0682</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71295">
        <property type="entry name" value="B71295"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882127.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83687"/>
    <dbReference type="SMR" id="O83687"/>
    <dbReference type="STRING" id="243276.TPANIC_0682"/>
    <dbReference type="EnsemblBacteria" id="AAC65645">
        <property type="protein sequence ID" value="AAC65645"/>
        <property type="gene ID" value="TP_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="57879207"/>
    <dbReference type="KEGG" id="tpa:TP_0682"/>
    <dbReference type="eggNOG" id="COG0293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_4_4_12"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="OrthoDB" id="1798571at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155545" description="Ribosomal RNA large subunit methyltransferase E">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <sequence length="200" mass="21318" checksum="BE3F15687CD02B5A" modified="1998-11-01" version="1">MNVYKRADFWAKKAAAAGYRARSVYKLAALDKKYSLLSRASRVLDLGAAPGSWTQYVLGTAAACTAVCAVDVQPIASDIQDARLQRVQGDLCAADTRARVACNAPFDLILSDAAPRTTGNRTVDTSASACLAAGVCAYVNFLSSDGGLVFKVFQGSEHLAILTHLRAHFGAVCSFKPPASRPRSCELYVVARFFRGTCGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83701</accession>
    <name>Y703_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0703</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0703</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71289">
        <property type="entry name" value="C71289"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83701"/>
    <dbReference type="STRING" id="243276.TPANIC_0702"/>
    <dbReference type="EnsemblBacteria" id="AAC65693">
        <property type="protein sequence ID" value="AAC65693"/>
        <property type="gene ID" value="TP_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0703"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1224300_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202307" description="Uncharacterized protein TP_0703">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="226" mass="24716" checksum="8919FF3F7052F51F" modified="1998-11-01" version="1">MGAERVGRAPGVNAKRAVQTQGVQSPSVKRSVRWVRGLCEVLLFSGVFVSAVSFLLHSAAVPPPERQVVPAHFERIAMQFPRQVSQGACAMATFSLVALQEKDKAHTEVHLVLRTPAGKEAKTVRAFALPPKGIAQLGTDAATAGVSRAGSQDVTHVALLGISIFWEPGDWMLEAQVRVPGGKPYVRRAPLRIEKKEFPREELRLDRKNTAIAQDKSERKKVQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83726</accession>
    <name>O83726_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71286">
        <property type="entry name" value="E71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882189.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83726">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0744"/>
    <dbReference type="EnsemblBacteria" id="AAC65712">
        <property type="protein sequence ID" value="AAC65712"/>
        <property type="gene ID" value="TP_0744"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75918">
        <property type="protein sequence ID" value="AGN75918"/>
        <property type="gene ID" value="TPANIC_0744"/>
    </dbReference>
    <dbReference type="GeneID" id="57879268"/>
    <dbReference type="KEGG" id="tpa:TP_0744"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.733"/>
    <dbReference type="eggNOG" id="COG2868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140910_3_0_12"/>
    <dbReference type="OMA" id="QNEYPDC"/>
    <dbReference type="OrthoDB" id="2065603at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="108" mass="11391" checksum="6D47C81BE3D1B11F" modified="1998-11-01" version="1">MLLEVGDRGQFLSAVASGHAARGTRGGDVVCAAVSVLLRTAVLGLERLGPQIEAADRGFLSFRVGGCPDSALALLCFTAEFLERGLRTLMQEYPSSVHLCVRRGVVCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83734</accession>
    <name>Y753_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0753</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0753</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71284">
        <property type="entry name" value="D71284"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882198.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83734"/>
    <dbReference type="SMR" id="O83734"/>
    <dbReference type="IntAct" id="O83734">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0753"/>
    <dbReference type="EnsemblBacteria" id="AAC65730">
        <property type="protein sequence ID" value="AAC65730"/>
        <property type="gene ID" value="TP_0753"/>
    </dbReference>
    <dbReference type="GeneID" id="57879276"/>
    <dbReference type="KEGG" id="tpa:TP_0753"/>
    <dbReference type="HOGENOM" id="CLU_2385255_0_0_12"/>
    <dbReference type="OMA" id="FIFFNID"/>
    <dbReference type="OrthoDB" id="1775064at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202315" description="Uncharacterized protein TP_0753">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="94" mass="10330" checksum="DEE0920E2A827877" modified="1998-11-01" version="1">MTYGKLIFFIIVLVGFALFMSFNVEHRCDVSLVFYTFQAVPITLSLLFAFACGALTALLFLIDPDAKTRKQKREDSPTSAPTGGVSSPEHVDVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83742</accession>
    <name>Y761_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0761</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0761</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71285">
        <property type="entry name" value="D71285"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882206.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83742"/>
    <dbReference type="SMR" id="O83742"/>
    <dbReference type="IntAct" id="O83742">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0761"/>
    <dbReference type="EnsemblBacteria" id="AAC65732">
        <property type="protein sequence ID" value="AAC65732"/>
        <property type="gene ID" value="TP_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="57879283"/>
    <dbReference type="KEGG" id="tpa:TP_0761"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952972_0_0_12"/>
    <dbReference type="OMA" id="AAWFHDF"/>
    <dbReference type="OrthoDB" id="912403at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014259" description="Uncharacterized protein TP_0761">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="292" mass="32411" checksum="8A316E46BA7E311D" modified="1998-11-01" version="1" precursor="true">MNSNSNKKRDPARFPAGVAQGCSTTRAGDLKHRRKHPFEKFFAQNSALFAQRFPDLARALTLPNEQLLQRIPPDYLLAAAHDGDATLAVRGTYLHSKYRPRQEAARLISQDFFTHAIAKGGYVGAGLGLGYVAELYAQQHPTHTVVLIEPDIFVFLLFLASRPLTPLLRHERLKILPAQTVPDVLQFLRATGDVSLPLFHFLPAQELNTAWFHDFTQAHRHATAQAETNKQTLQRFGPLWIRNTIKNAAQLCVRTPVNALRNCAAGSTALIIAGGPGVDASISFLPYLKKKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83767</accession>
    <name>Y788_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0788</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0788</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71280">
        <property type="entry name" value="C71280"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882233.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83767"/>
    <dbReference type="IntAct" id="O83767">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65763">
        <property type="protein sequence ID" value="AAC65763"/>
        <property type="gene ID" value="TP_0788"/>
    </dbReference>
    <dbReference type="GeneID" id="57879309"/>
    <dbReference type="KEGG" id="tpa:TP_0788"/>
    <dbReference type="eggNOG" id="ENOG50347X1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015418_0_0_12"/>
    <dbReference type="OMA" id="HEYGVIF"/>
    <dbReference type="OrthoDB" id="905221at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202326" description="Uncharacterized protein TP_0788">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="296" mass="33638" checksum="1965B9EBC513F0EA" modified="1998-11-01" version="1">MRVRTFCFSLVCALGASTYLLWRGWLQLSLPAGSYGVMRSRSGGYHHALIAPGRFLWRWEPLLPSNAELFAFELKKQTVSVTVQDVLPAAKEYAQLLDQHAPFDWTLALSARVALKEAFLLDTVQRERITDQNSLERYVDTTAQAALTQVSHDFIARCMADPALYERVHTQYGLATRELKRAIEKEIPHCAISEVVLSEVHIPDMVLYHTAEQAYRAFEAKRSEHLSALAQQAAKRSALENFEMQRLTKWGEFFQRYPSVIDFLNAIRQDGASTLETLKKGSTASHRAIPHEETTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>O83788</accession>
    <name>Y811_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0811</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0811</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71278">
        <property type="entry name" value="A71278"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83788"/>
    <dbReference type="EnsemblBacteria" id="AAC65784">
        <property type="protein sequence ID" value="AAC65784"/>
        <property type="gene ID" value="TP_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0811"/>
    <dbReference type="HOGENOM" id="CLU_3278194_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202331" description="Uncharacterized protein TP_0811">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <sequence length="41" mass="4658" checksum="0F7ACE8C92D0363D" modified="1998-11-01" version="1">MAGIVSAFVTFFYRFISFTTSYVQCVRSIIAEHAGPHGWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83791</accession>
    <name>O83791_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71278">
        <property type="entry name" value="D71278"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882259.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0815"/>
    <dbReference type="EnsemblBacteria" id="AAC65786">
        <property type="protein sequence ID" value="AAC65786"/>
        <property type="gene ID" value="TP_0815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75985">
        <property type="protein sequence ID" value="AGN75985"/>
        <property type="gene ID" value="TPANIC_0815"/>
    </dbReference>
    <dbReference type="GeneID" id="57879333"/>
    <dbReference type="KEGG" id="tpa:TP_0815"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.801"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076898_0_0_12"/>
    <dbReference type="OMA" id="KASHESC"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36194" checksum="538C1E0AD685DACB" modified="1998-11-01" version="1">MSFAKGSGGVVRRCALDLPGASRAMHAFCLLCTSVVGDIVSRLVRNLDAHTIDEALAFVKSREAFSVSLAEYLKAAKCSFSTRGTAPFIRGGSVLYRDAEPCAVLLLTRAGLLLHNSEPNTNSAAIYRACKRLVTAQVRSIVGTEMHTCVIARSISGITTHAQQERYYLLVLPLHTPRVEYEQNSAPLHIRRAQLKDMRELFPLHMHYKREEVLPVGNSPKHKATVRTLHAHLRTRVIFHASIGGHIVAKAQTNAHGFHCHQIGGVYTVPAYRNRGIATALVATLAYNRLDIGKTPVLFVKVRNMAARRVYEKIGFTLHGLYRVINL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O83816</accession>
    <name>G3P_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="1">GAPDH</shortName>
            <ecNumber evidence="2">1.2.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">gap</name>
        <name type="ordered locus">TP_0844</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71273">
        <property type="entry name" value="D71273"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882288.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83816"/>
    <dbReference type="SMR" id="O83816"/>
    <dbReference type="IntAct" id="O83816">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0844"/>
    <dbReference type="PRIDE" id="O83816"/>
    <dbReference type="EnsemblBacteria" id="AAC65812">
        <property type="protein sequence ID" value="AAC65812"/>
        <property type="gene ID" value="TP_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="57879361"/>
    <dbReference type="KEGG" id="tpa:TP_0844"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_12"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000145712" description="Glyceraldehyde-3-phosphate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P09124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P0A9B2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="350" mass="38083" checksum="E305A8F535913CAA" modified="1998-11-01" version="1">MRVAINGFGRIGRLVLQAMAEQKLLGKEFDVAAVVDLSTDARYFAYQLKYDSVQGKMGSSLSAPAEDILEVGGHRIKCVCGRGLKPSQLPWKDLGIEVVIEATGIYANESSYGHLEAGAKRVIISAPAKSSDASKPVKTIVMGVNEHEFDPAEHKVVSNASCTTNCLAPVVHVFLKEGVGIETGLMTTIHSYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGEVLPSTRGKLTGMAFRVPTPTGSVVDLTFRTEKETSVADLNAMLKKASESYLRGVLQYCDEDIVSADVIHNQYSSIYDSRATLQNNLPNEKRFFKVVSWYDNEWGYSNRVVDLLKFISQKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83821</accession>
    <name>RL35_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">TP_0849</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71274">
        <property type="entry name" value="A71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882293.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83821"/>
    <dbReference type="SMR" id="O83821"/>
    <dbReference type="IntAct" id="O83821">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0849"/>
    <dbReference type="EnsemblBacteria" id="AAC65815">
        <property type="protein sequence ID" value="AAC65815"/>
        <property type="gene ID" value="TP_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0849"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_1_1_12"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000177447" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <sequence length="66" mass="7549" checksum="5C9FE49683A9942D" modified="1998-11-01" version="1">MAKMKTKSAAAKRFSVTGAGKVKFKKMNLRHILTKKAPKRKRKLRHAGFLSKVELKVVKRKLLPYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83824</accession>
    <name>LGT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt</name>
        <name type="ordered locus">TP_0852</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71274">
        <property type="entry name" value="D71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882296.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83824"/>
    <dbReference type="SMR" id="O83824"/>
    <dbReference type="STRING" id="243276.TPANIC_0852"/>
    <dbReference type="EnsemblBacteria" id="AAC65817">
        <property type="protein sequence ID" value="AAC65817"/>
        <property type="gene ID" value="TP_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0852"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_0_12"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172706" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="332" mass="38154" checksum="6FD260564892269D" modified="1998-11-01" version="1">MLSIVYPSWIRPEIIPSFPYFRWYGFMYVVAFSIAYILFRYQVRRGELDKWSRVSEPVTQDDIMSFFTWTILGILIGARVFSTMVYEVDLLYMRKPWLIFWPFSLQTGEWVGLRGMSYHGGLIGALVGGGLWTQSHGRSFLAWADVAAASTPLGYTFGRIGNFLNAELYGRITDIPIGMIFPNVPLSDMFPASEPWVREFAQRVGIHVQEGARLVNLPRHPSQIYEAFFEGIVLWCILWCARRVKTYNGFLVCLYVVGYGVFRFFIEYFRQPDAHLGYRFSATQSSPIYLFQSWSDVSTGQILCVLMILAGLGGMFALSAYHKRDSVRKARV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83831</accession>
    <accession>O83832</accession>
    <name>Y859_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0164 protein TP_0859/TP_0860</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0859/TP_0860</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0164 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAC65832" version="1"/>
        </conflict>
        <text>Produces two separate ORFs.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65831.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65832.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71272">
        <property type="entry name" value="C71272"/>
    </dbReference>
    <dbReference type="PIR" id="D71272">
        <property type="entry name" value="D71272"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_014342835.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83831"/>
    <dbReference type="IntAct" id="O83831">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0859"/>
    <dbReference type="EnsemblBacteria" id="AAC65831">
        <property type="protein sequence ID" value="AAC65831"/>
        <property type="gene ID" value="TP_0859"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65832">
        <property type="protein sequence ID" value="AAC65832"/>
        <property type="gene ID" value="TP_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0859"/>
    <dbReference type="KEGG" id="tpa:TP_0860"/>
    <dbReference type="eggNOG" id="ENOG5033RFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194462_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005362">
        <property type="entry name" value="UPF0164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03687">
        <property type="entry name" value="UPF0164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000036219" description="UPF0164 protein TP_0859/TP_0860">
        <location>
            <begin position="45"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="494" mass="52883" checksum="5B419C60CCEAF840" modified="2001-06-01" version="2" precursor="true">MVRRPCVSAAPVRVGGRLVFGFARVGSRGLCLGALLLSPRIVLAQHVADAPLGARGVVPRSSLPRRTRAARATTLRSRGGVVSSRASGGTLVVTAQKPKVMARNDVDYRPLSLQAGGRQGSLDLVATATADDASFFEANAAGSATIPRMTLAFFHTMRISDSHIDVLSFVGRAGRTGYGVSARAFYPDMSSKTTGFVGIFNVSHAFSSAYRFKGVSVGANLKVGYRHTRGGGSSQSKSSNGKENHHIVLTADVGVRGAWTVSKNFGAHEPNLWAGVAFRNIGASINATNLHGNNGAGGSGGGGGGNGDGKPAHVTDSRVILALAYQPVRYFLFGAGLEWLYNVGSIKAVNSLRYGAAFMLFPLRQLAFSSSVVMKGMGPQQVRASAGAEVQFSHVRCTASYSYLWSATPTRPHYVSIGVAGFLKPVPEQPLWQEVYRSYLRGLRHYHAQRYAEAIAEWKRTLQQGVSFEPAREGIERATKLLQLNQKVHDFNIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83855</accession>
    <name>DUT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dut</name>
        <name type="ordered locus">TP_0885</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71269">
        <property type="entry name" value="B71269"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882328.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83855"/>
    <dbReference type="SMR" id="O83855"/>
    <dbReference type="STRING" id="243276.TPANIC_0885"/>
    <dbReference type="EnsemblBacteria" id="AAC26575">
        <property type="protein sequence ID" value="AAC26575"/>
        <property type="gene ID" value="TP_0885"/>
    </dbReference>
    <dbReference type="GeneID" id="57879399"/>
    <dbReference type="KEGG" id="tpa:TP_0885"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_2_12"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182913" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <sequence length="146" mass="15376" checksum="561451F2BE54DE11" modified="1998-11-01" version="1">MIRVRAVVYPGASFPEYQTLGSSGADLRAFLPGGPLEVHPLGRVLVPTGVCVELPVGLEMQIRPRSGLALEYGVTVLNSPGTIDADYRGEIRVLLVNLGLAAFVVSHGDRIAQAVISSVLRVEYVRSGSISLTERGKGGYGSTGVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83866</accession>
    <name>Y896_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0896</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0896</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71266">
        <property type="entry name" value="E71266"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83866"/>
    <dbReference type="IntAct" id="O83866">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0896"/>
    <dbReference type="EnsemblBacteria" id="AAC65866">
        <property type="protein sequence ID" value="AAC65866"/>
        <property type="gene ID" value="TP_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0896"/>
    <dbReference type="HOGENOM" id="CLU_3123858_0_0_12"/>
    <dbReference type="OMA" id="YVTRYVE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202346" description="Uncharacterized protein TP_0896">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <sequence length="50" mass="5735" checksum="755EA69638E72301" modified="1998-11-01" version="1">MSLDLVGMYGSFLSEGANLRPFGRYAKIPRIGSHMTRYVEFLRRRISGRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83874</accession>
    <name>Y904_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0904</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0904</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71267">
        <property type="entry name" value="E71267"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882347.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83874"/>
    <dbReference type="STRING" id="243276.TPANIC_0904"/>
    <dbReference type="EnsemblBacteria" id="AAC65869">
        <property type="protein sequence ID" value="AAC65869"/>
        <property type="gene ID" value="TP_0904"/>
    </dbReference>
    <dbReference type="GeneID" id="57879595"/>
    <dbReference type="KEGG" id="tpa:TP_0904"/>
    <dbReference type="HOGENOM" id="CLU_2541589_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202348" description="Uncharacterized protein TP_0904">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <sequence length="83" mass="9659" checksum="A87E7CF3D62E3465" modified="1998-11-01" version="1">MNKNTQDKGTPAALQVFLLPQYNRYSAEMTRHVPLLCNLFSMSRYVLRHLTAQIILERMSAACVCLRRRRQSEFTDPTEKIGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83898</accession>
    <name>Y928_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0928</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0928</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71264">
        <property type="entry name" value="A71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882371.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83898"/>
    <dbReference type="IntAct" id="O83898">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65887">
        <property type="protein sequence ID" value="AAC65887"/>
        <property type="gene ID" value="TP_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0928"/>
    <dbReference type="HOGENOM" id="CLU_1128659_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202354" description="Uncharacterized protein TP_0928">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="246" mass="27471" checksum="97A54648E91473E7" modified="1998-11-01" version="1">MKSFYFGRGALASTGGCVVLAVAALMFVFLPALSGGGHGHVRLGSWGGVALTNAPDSLFSQQYSALAQTAERYNLYPKDAQEREGMDRRVLRAAFRAAVVQLAGTEQTKQSGFTLSEELLDREVLSFYADADGTYSPQRYQGTPEHVRLSQRKKMRDSLLSDQYLYHLFGKETGRGGLKLNSRELRFVQDMAKKERSFRYVVLGEERFPAERVSRTGKSMPTFLPCITFPCSPTPRKRTRAARHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="149" xmlns="http://uniprot.org/uniprot">
    <accession>O83909</accession>
    <name>O83909_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TP_0939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Nichols</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71262">
        <property type="entry name" value="G71262"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882382.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83909">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0939"/>
    <dbReference type="EnsemblBacteria" id="AAC65895">
        <property type="protein sequence ID" value="AAC65895"/>
        <property type="gene ID" value="TP_0939"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76104">
        <property type="protein sequence ID" value="AGN76104"/>
        <property type="gene ID" value="TPANIC_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="57879450"/>
    <dbReference type="KEGG" id="tpa:TP_0939"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.922"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_12"/>
    <dbReference type="OMA" id="NTVMQVC"/>
    <dbReference type="OrthoDB" id="10483at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
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        </ligand>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1184" mass="129816" checksum="25040E04FD9D63C7" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83910</accession>
    <name>Y940_TREPA</name>
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        <recommendedName>
            <fullName>Uncharacterized protein TP_0940</fullName>
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        <name type="ordered locus">TP_0940</name>
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    <organism>
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        <dbReference type="NCBI Taxonomy" id="243276"/>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAC65899.1"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65899">
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    <dbReference type="HOGENOM" id="CLU_3190276_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
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    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <sequence length="46" mass="4930" checksum="59282C075A0270EE" modified="1998-11-01" version="1">MFFEKKRESRVQPMHIQAGCATIAGTRGDRGGYGACFPAPGCPDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83924</accession>
    <name>O83924_TREPA</name>
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        <submittedName>
            <fullName evidence="10">Dicarboxylate transporter (DctM)</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
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            <taxon>Treponemataceae</taxon>
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        </lineage>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
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                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
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                <person name="Peterson J."/>
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            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
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    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AAC65914"/>
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        <property type="protein sequence ID" value="AGN76123"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
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        <property type="entry name" value="TRAP_DctM"/>
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    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
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        <property type="entry name" value="PTHR33362"/>
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        <property type="entry name" value="DctM"/>
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        <property type="entry name" value="dctM"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="9">
        <location>
            <begin position="220"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="632" mass="67614" checksum="8667E2F9F0D3F377" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83928</accession>
    <name>O83928_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71259">
        <property type="entry name" value="E71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882406.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83928">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0962"/>
    <dbReference type="EnsemblBacteria" id="AAC65917">
        <property type="protein sequence ID" value="AAC65917"/>
        <property type="gene ID" value="TP_0962"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76127">
        <property type="protein sequence ID" value="AGN76127"/>
        <property type="gene ID" value="TPANIC_0962"/>
    </dbReference>
    <dbReference type="GeneID" id="57879472"/>
    <dbReference type="KEGG" id="tpa:TP_0962"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.946"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_12"/>
    <dbReference type="OMA" id="IQKYPAT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="410" mass="44605" checksum="FD4ECDCFB33CE377" modified="1998-11-01" version="1">MLEDIVNTLLYFRQRVLRTTLSFLGIAVGVASVVVITSIGESLYASLAQSVGEGERRLIRVRPEWDYVKNEIMFQPTESYRTRLVQSSEDIEGVFYNSSLKALISSPHTGGKERNITGVEPRWLELKDFKLEYGTFFSPADFKTHRHCAVIGGLLAQELFPEGNALGKRMTVTILSRASGAERALSFPFEIVGVLQEKGSLISGIPSYRVFVPREFISLEMGAGRVADAVEVCVRDVQVIAAAEKRIREFSDFFSNKSGSVSLWSGAGEIKSFRSVLSMVSVVLSVVAAVSLIVGGINIMNIMVVTVTERRREIGLRKAVGATCATIVQQFLLEAVLLTLAGCVCGLILGMVLSYGLFSVFSPEGITVVFSLSTAGMRTAFFMSLGAGIFFGLKPALQASRLDPIIALAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83932</accession>
    <name>Y966_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0966</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0966</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TP096X family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71260">
        <property type="entry name" value="A71260"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882410.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83932"/>
    <dbReference type="IntAct" id="O83932">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0966"/>
    <dbReference type="EnsemblBacteria" id="AAC65924">
        <property type="protein sequence ID" value="AAC65924"/>
        <property type="gene ID" value="TP_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0966"/>
    <dbReference type="eggNOG" id="ENOG5032M6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499595_0_0_12"/>
    <dbReference type="OMA" id="ILEYRCK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014267" description="Uncharacterized protein TP_0966">
        <location>
            <begin position="35"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="544" mass="60148" checksum="123D5C731F3E6F11" modified="1998-11-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>O83953</accession>
    <name>O83953_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 inner membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71256">
        <property type="entry name" value="D71256"/>
    </dbReference>
    <dbReference type="IntAct" id="O83953">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0988"/>
    <dbReference type="EnsemblBacteria" id="AAC65944">
        <property type="protein sequence ID" value="AAC65944"/>
        <property type="gene ID" value="TP_0988"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76152">
        <property type="protein sequence ID" value="AGN76152"/>
        <property type="gene ID" value="TPANIC_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0988"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.973"/>
    <dbReference type="eggNOG" id="COG2095">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Multi_antbiot-R_MarC"/>
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        <property type="entry name" value="MarC"/>
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    </dbReference>
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        <location>
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            <end position="110"/>
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        <location>
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            <end position="147"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="278" mass="30912" checksum="D1F0429BE4B5407E" modified="1998-11-01" version="1">MLCMLEMDSARQRFVRDVEHIRHEDMHEMGICARRGFTCSDTHPHRKRHSQKKCCTRAVPTQGNGDCRTRGSSRILTPRMSTWTHIWSTAFTLLFIIDPIGNIPVVLSVLRTVPAERHTRIIFRELLLGLVLMLSFLFCGKVFLSLFQLETGVMKMAGSVILFLVGIKMVFPDQHALPSTTEEEPFIVPIATPMIAGPSAFTTLVIMGETKGTSRLATCAALLVAWTLACLIMISAPCLYRLLKEKGITALERITGILLLILSIQMCVEGARGIIATS</sequence>
</entry>
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    <accession>O83955</accession>
    <name>O83955_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TP_0990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76154">
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        <property type="gene ID" value="TPANIC_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0990"/>
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    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006550_0_0_12"/>
    <dbReference type="OMA" id="GESIVPW"/>
    <dbReference type="OrthoDB" id="98549at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
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        <property type="entry name" value="TPR_6"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
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        <location>
            <begin position="848"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="1033" mass="116827" checksum="FB384A3F77D14AE2" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83963</accession>
    <name>O83963_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/proton-dependent alanine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAC26586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="G71255"/>
    </dbReference>
    <dbReference type="IntAct" id="O83963">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0998"/>
    <dbReference type="EnsemblBacteria" id="AAC26586">
        <property type="protein sequence ID" value="AAC26586"/>
        <property type="gene ID" value="TP_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0998"/>
    <dbReference type="eggNOG" id="COG1115">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024867_0_1_12"/>
    <dbReference type="OMA" id="PMMALFY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC26586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="500" mass="53949" checksum="523E2E292C39D947" modified="1998-11-01" version="1">MRGGNRRDPISCNGKMLCVTLDGRALXLFYPLKLEGISMTAFQALLIRLVDALHSYILVGWLVVCGVFFTIKTGCVQLSLLKPAFAALAEKRGKGVSSFQALMISTASRVGAGNIVGVATAIAFGGKGAVFWMWVSAFFGAASAFVESTLAQAYKTRTACGFRGGPAYYIEMGLKSRSMGVLFALCLVFAYAYGFNALQAYNIVSTLSYYGKDSSLWVQILAVLLSFLLAFVIFGGVARISVVSSVIVPVMAVGYVFLGLWVLALNVYRLPALFFEICREGLSLTAFAGGTFGSVVVIGIKRGLLSHEAGMGSAPNAAASAEVSHPVVQGLVQALSVFIDTMLICSVTAFVLLLSDVAGSVDVSGMQFVQQALSKQVGPVGVHLVTLAIFLFAFSSLMGNYYYAESNVRFIKDHKMVLSVFRVTCVSAVFVGAHASFHFVWGVADLFMVFMTVINLIAIVTLHPVALYLLRDYRKQYRAGNVPVFFQEHLVFPEKMACRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83965</accession>
    <name>YA00_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1000</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1000</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71254">
        <property type="entry name" value="B71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882444.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83965"/>
    <dbReference type="EnsemblBacteria" id="AAC65957">
        <property type="protein sequence ID" value="AAC65957"/>
        <property type="gene ID" value="TP_1000"/>
    </dbReference>
    <dbReference type="GeneID" id="57879511"/>
    <dbReference type="KEGG" id="tpa:TP_1000"/>
    <dbReference type="eggNOG" id="ENOG5031UE2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1495558_0_0_12"/>
    <dbReference type="OMA" id="HRRKGAC"/>
    <dbReference type="OrthoDB" id="2128493at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202370" description="Uncharacterized protein TP_1000">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <sequence length="223" mass="25429" checksum="770AB73F904F530E" modified="1998-11-01" version="1">MQAGDTLPFYSNADYQPHRRKGVCSAAHRADVQRGETMMREDVRMHVLRRRISFHYRVDPLKGDSFENNWANNSCDTMQLQDKAGRVLYGAMVQTVANYCFGRMAPGSGVAHGESVAPGAFVVRCFVPARAFHGRIHAITRTWDMDGEWIDREAMQISTEGYQTGRWLIHDRWSEKLGRDTNYAWSAGCFVLSSEDLRRMNEVLDRWGVSCGQEMAGILEELE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83978</accession>
    <name>Y1014_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1014</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1014</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71253">
        <property type="entry name" value="B71253"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882458.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83978"/>
    <dbReference type="STRING" id="243276.TPANIC_1014"/>
    <dbReference type="EnsemblBacteria" id="AAC65972">
        <property type="protein sequence ID" value="AAC65972"/>
        <property type="gene ID" value="TP_1014"/>
    </dbReference>
    <dbReference type="GeneID" id="57879525"/>
    <dbReference type="KEGG" id="tpa:TP_1014"/>
    <dbReference type="eggNOG" id="ENOG5031C4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492532_0_0_12"/>
    <dbReference type="OMA" id="GKESIIR"/>
    <dbReference type="OrthoDB" id="201840at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202373" description="Uncharacterized protein TP_1014">
        <location>
            <begin position="1"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="644" mass="71127" checksum="564A8BE8307DBD1F" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-04-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>P29725</accession>
    <name>BMP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Basic membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tpn39b</name>
        <name type="ordered locus">TP_1016</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1987" name="Infect. Immun." volume="55" first="1106" last="1115">
            <title>Identification and purification of a recombinant Treponema pallidum basic membrane protein antigen expressed in Escherichia coli.</title>
            <authorList>
                <person name="Dallas W.S."/>
                <person name="Ray P.H."/>
                <person name="Leong J."/>
                <person name="Benedict C.D."/>
                <person name="Stamm L.V."/>
                <person name="Bassford P.J. Jr."/>
            </authorList>
            <dbReference type="PubMed" id="3552988"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="M17716">
        <property type="protein sequence ID" value="AAA27475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A43510">
        <property type="entry name" value="A43510"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882460.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P29725"/>
    <dbReference type="SMR" id="P29725"/>
    <dbReference type="IntAct" id="P29725">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1016"/>
    <dbReference type="PRIDE" id="P29725"/>
    <dbReference type="EnsemblBacteria" id="AAC65966">
        <property type="protein sequence ID" value="AAC65966"/>
        <property type="gene ID" value="TP_1016"/>
    </dbReference>
    <dbReference type="GeneID" id="57879527"/>
    <dbReference type="KEGG" id="tpa:TP_1016"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_2_0_12"/>
    <dbReference type="OMA" id="KKEFAIN"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000020822" description="Basic membrane protein">
        <location>
            <begin position="21"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="361" mass="39936" checksum="A6F8C6CE8FFCCABB" modified="1993-04-01" version="1" precursor="true">MGRYIVPALLCVAGMGFAHAQSALQPIAEVNLFRREPVTLGQIKARISAIEKEMGKKLSTAERRQFMDSLIDEKLFAQAAEKAGIQVTDAEVNQYFNGMLSQQIGRAVTEAEFANYVKEKQNISLDQFMKQQNGMTMAEYKKFLKTQVSTQRYVAQKKADEFRNLKGPEDSQIRSYYELNKQAFFRPDTVKLFLISVPKGSGPAAAKAKAQEFVKKLKSSGVKATADIKSKANGAQAGYSAGEIYLGKTAVTATQLGLTMEALLEIFGMGVGAVSDVNETANDYQCFIVLKKEEAKILTLSDLVEPDKTVSLYEFIKNLLTSQIQQKALEDAIREVSAELRKSGTYKVFLADAELGKVLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUB5</accession>
    <name>F7IUB5_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar motor switch protein FliN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TP_0720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4505">
        <property type="entry name" value="JC4505"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882165.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0720"/>
    <dbReference type="EnsemblBacteria" id="AAC65686">
        <property type="protein sequence ID" value="AAC65686"/>
        <property type="gene ID" value="TP_0720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75895">
        <property type="protein sequence ID" value="AGN75895"/>
        <property type="gene ID" value="TPANIC_0720"/>
    </dbReference>
    <dbReference type="GeneID" id="57879245"/>
    <dbReference type="KEGG" id="tpa:TP_0720"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.710"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033893_0_0_12"/>
    <dbReference type="OMA" id="MMGGDGK"/>
    <dbReference type="OrthoDB" id="1875967at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="348" mass="37135" checksum="C91760FD4B6822AE" modified="2011-07-27" version="1">MSDGSISQAEIDALLSGVEMGAGDSPAAGASFSGGGLSSAQSELLQSFCQANVGSFCPSLESLTGKTVSISPPRVEISSKEEFSRVIPDMLVATVIDFEGEFAGDHLFLMAPEFAQKLVNLVSHEDNDQIDDMGLSVVSETITQYVSAQLSTLEARNVQNVSVAPAESVQVPKAMVRFPPQRLCVFTYTVELDGTSYTLWELVSEQLMVRIIERMGGAMQRPQAQVGNSQMGGVNMQMGIGAASPSVQSVQFHPLQNAAGGAEQGNIGLIMDVFMEVTVELGRTRMMIKDILGMGEGHIIELDKLAGEPVDILVNHKLIAKGEVVVIDENFGVRVTEILSPGERIADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F7IVK2</accession>
    <name>F7IVK2_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein (CheX)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71335">
        <property type="entry name" value="C71335"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881813.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0365"/>
    <dbReference type="EnsemblBacteria" id="AAC65350">
        <property type="protein sequence ID" value="AAC65350"/>
        <property type="gene ID" value="TP_0365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75562">
        <property type="protein sequence ID" value="AGN75562"/>
        <property type="gene ID" value="TPANIC_0365"/>
    </dbReference>
    <dbReference type="GeneID" id="57878893"/>
    <dbReference type="KEGG" id="tpa:TP_0365"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.364"/>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116290_1_0_12"/>
    <dbReference type="OMA" id="NVEYINP"/>
    <dbReference type="OrthoDB" id="1956590at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="154" mass="16612" checksum="EEC72267CFEB2834" modified="2011-07-27" version="1">MRVEYINPFSEAAYVVLSEVLAGETKRGDLYLKSTCMPVMGVAAIVGLAGDVEGRVVFDMTLDTALKIASSMNEEKLAAFDELARATITELANLITAKAVTTLHELGFKFDLTPPALFTGDNMEISSSDIEALIVPMETPQGKVEINVAIRDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW56</accession>
    <name>F7IW56_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat protein TpLRR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71350">
        <property type="entry name" value="G71350"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881673.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="F7IW56"/>
    <dbReference type="STRING" id="243276.TPANIC_0225"/>
    <dbReference type="EnsemblBacteria" id="AAC65213">
        <property type="protein sequence ID" value="AAC65213"/>
        <property type="gene ID" value="TP_0225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75438">
        <property type="protein sequence ID" value="AGN75438"/>
        <property type="gene ID" value="TPANIC_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0225"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.228"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1133200_0_0_12"/>
    <dbReference type="OMA" id="AFKQCES"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007658744" evidence="2">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26569" checksum="A61B3761CF840F3C" modified="2011-07-27" version="1">MPKQVVVFAMWCIGLGVLVSHPVSAKQNAVSRAEVKETPAKFFQYGLTPDRDGIIITRYLGKGIAVVLPSQIDGLPVVEVATKAFYGCVSLVRVSLPSSVRMIGQHAFDGCTKLARIELPDGLREIRHHAFHKCVSLAGIVFPRSLQVIGQDVFSSCGSLVDVVLPNSVKEIGSGAFRDCAELASVRLPVGVKNLADGLFEGCRNLVELGNLPEKVSFGVGVFVGCYRLPDVLKRSVRKLGYKGEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O07888</accession>
    <name>FLIL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliL</name>
        <name type="ordered locus">TP_0722</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="4628" last="4634">
            <title>Organization, transcription, and expression of the 5' region of the fla operon of Treponema phagedenis and Treponema pallidum.</title>
            <authorList>
                <person name="Limberger R.J."/>
                <person name="Slivienski L.L."/>
                <person name="El-Afandi M.C."/>
                <person name="Dantuono L.A."/>
            </authorList>
            <dbReference type="PubMed" id="8755894"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliL family.</text>
    </comment>
    <dbReference type="EMBL" id="U28219">
        <property type="protein sequence ID" value="AAB61255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71291">
        <property type="entry name" value="F71291"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882167.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O07888"/>
    <dbReference type="IntAct" id="O07888">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0722"/>
    <dbReference type="EnsemblBacteria" id="AAC65688">
        <property type="protein sequence ID" value="AAC65688"/>
        <property type="gene ID" value="TP_0722"/>
    </dbReference>
    <dbReference type="GeneID" id="57879247"/>
    <dbReference type="KEGG" id="tpa:TP_0722"/>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126053_0_0_12"/>
    <dbReference type="OMA" id="VITYRIM"/>
    <dbReference type="OrthoDB" id="1770108at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0283">Flagellar rotation</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000180919" description="Flagellar protein FliL">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="182" mass="20334" checksum="A793B7BC755A80E1" modified="1997-07-01" version="1">MAEKDSIGDIADDFEEQLVAPAADRVGFLPGLLRWVAIAVGAVIFIVTVVTATALVLAKQGSSHTAYPVSQEFRESRELLQYYESVGLIRTNTADALPGTVVVSVALGYPLNDKTAQQELSARLVELKDFLRSYFQRKTLSELRPEHEQKVKIEIRNEINDNVLSRSKVKDIRFTQFDVLKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O54312</accession>
    <name>MURA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="1">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA</name>
        <name type="ordered locus">TP_0029</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1990-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Hindersson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="X54111">
        <property type="protein sequence ID" value="CAA38047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71374">
        <property type="entry name" value="G71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881478.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O54312"/>
    <dbReference type="SMR" id="O54312"/>
    <dbReference type="IntAct" id="O54312">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0029"/>
    <dbReference type="EnsemblBacteria" id="AAC65025">
        <property type="protein sequence ID" value="AAC65025"/>
        <property type="gene ID" value="TP_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0029"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_1_12"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000178947" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="425" mass="45542" checksum="6AA2E3193FA9F452" modified="1998-06-01" version="1">MSCYRVEGGFPVSGCIRVCGNKNAALPCIAAAVLTQEPVLLQNVPDIEDVAVMLTIFRAFGGSVERRGNHEYMLHLPQLQTCEVPCEAAQKVRASILFAGPLLARGRKAVLPPPGGDVIGRRRLDTHFLALAALGAQVRLDGVFTFSANKLVGCDVFLDEASVTATENVLMASVLAEGVTVITNAASEPHVQDLCHLLNAMGARVSGIGSNVLTIEGVSALHGTTYTLGADFMEVGSLIGLAVVTRGALTISDVNVRDLRPLGFAFKKLGVIWSEQEHAVSVSASQDLRVNYDFGGMIPKIDDGPWPAFPPDLTSIMTVVATQVEGVILIHEKMFESRMFFVDKLITMGARIILCDPHRALVSGPSALHGSDLVSPDVRAGMAMVLAACCARGVSIIRNVYQIERGYERLVERLQAIGVRIWKEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O66105</accession>
    <name>PPIB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName>PPIase</shortName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ppiB</name>
        <name type="synonym">ppi</name>
        <name type="ordered locus">TP_0947</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Infect. Immun." volume="65" first="4179" last="4189">
            <title>Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Shevchenko D.V."/>
                <person name="Akins D.R."/>
                <person name="Robinson E.J."/>
                <person name="Li M."/>
                <person name="Shevchenko O.V."/>
                <person name="Radolf J.D."/>
            </authorList>
            <dbReference type="PubMed" id="9317025"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>PARTIAL PROTEIN SEQUENCE</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="U97573">
        <property type="protein sequence ID" value="AAC08055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71261">
        <property type="entry name" value="A71261"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882390.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O66105"/>
    <dbReference type="SMR" id="O66105"/>
    <dbReference type="IntAct" id="O66105">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0947"/>
    <dbReference type="EnsemblBacteria" id="AAC65904">
        <property type="protein sequence ID" value="AAC65904"/>
        <property type="gene ID" value="TP_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0947"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_4_12"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000064213" description="Probable peptidyl-prolyl cis-trans isomerase">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="215" mass="23272" checksum="CCA1589C1F5A6D0B" modified="1998-08-01" version="1">MNTQVWRVCVGVMLFCFVGRIGCAEEKMVREEGLAVADGIYAVMETNRGTIVLSLFFEKAPLTVCNFVGLAEGTLAVCKGRPFYQGLTFHRVIKDFMIQGGDPQGNGTGGPGYQFPDECDPALRHDSPGVLSMANAGPGTNGSQFFITHVATPWLDGKHTVFGKVVEGMEVVHAIIAGDTIRSLKIVRRGAAAKRFVCDQAQFDQLRKRVSAASK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83050</accession>
    <name>Y004_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0004</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0004</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1584836">
            <id>O83050</id>
        </interactant>
        <interactant intactId="EBI-1585657">
            <id>O08399</id>
            <label>gyrB</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71378">
        <property type="entry name" value="C71378"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881454.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83050"/>
    <dbReference type="IntAct" id="O83050">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0004"/>
    <dbReference type="EnsemblBacteria" id="AAC65005">
        <property type="protein sequence ID" value="AAC65005"/>
        <property type="gene ID" value="TP_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="57878546"/>
    <dbReference type="KEGG" id="tpa:TP_0004"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786045_0_0_12"/>
    <dbReference type="OMA" id="HSAIEDI"/>
    <dbReference type="OrthoDB" id="1765342at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202170" description="Uncharacterized protein TP_0004">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="145" mass="16338" checksum="6D66674C8EFFCFAC" modified="1998-11-01" version="1">MNNGVNKLSDLLVLTTEYIQASYETEAFDAHREWVCIVGNPVALHSTLVDIRNGKVVVKVTHPGWAQYLLLKKDEIVHALRRRYPSLGVTGMSTYVDSTSRTPSAKKDMQGLSVSEKQTRPVPELAEVFEQLRTLFQVKTEEPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83069</accession>
    <name>O83069_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">M16C_associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71376">
        <property type="entry name" value="E71376"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881474.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83069">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0025"/>
    <dbReference type="EnsemblBacteria" id="AAC65019">
        <property type="protein sequence ID" value="AAC65019"/>
        <property type="gene ID" value="TP_0025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75246">
        <property type="protein sequence ID" value="AGN75246"/>
        <property type="gene ID" value="TPANIC_0025"/>
    </dbReference>
    <dbReference type="GeneID" id="57878567"/>
    <dbReference type="KEGG" id="tpa:TP_0025"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.21"/>
    <dbReference type="eggNOG" id="COG1026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_1_0_12"/>
    <dbReference type="OMA" id="MTYPDKT"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="1">
        <location>
            <begin position="460"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="1023" mass="114105" checksum="1E776DCCD4E2319E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83076</accession>
    <name>O83076_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71375">
        <property type="entry name" value="C71375"/>
    </dbReference>
    <dbReference type="IntAct" id="O83076">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0033"/>
    <dbReference type="EnsemblBacteria" id="AAC65028">
        <property type="protein sequence ID" value="AAC65028"/>
        <property type="gene ID" value="TP_0033"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75254">
        <property type="protein sequence ID" value="AGN75254"/>
        <property type="gene ID" value="TPANIC_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0033"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.29"/>
    <dbReference type="eggNOG" id="COG4330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081833_1_0_12"/>
    <dbReference type="OMA" id="WLLFLPN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009793">
        <property type="entry name" value="DUF1361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07099">
        <property type="entry name" value="DUF1361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="203" mass="23999" checksum="E4544E3457A063EA" modified="1998-11-01" version="1">MSVFCLLLSFGRRCVAADNFLSFLVWNLVLAFIPWLISAILHVRRFAVRSVQLFLMLLWLLFFPNAPYILTDIIHLGKGKSFLLYYDLIILLAYSFTGLFYAFVSLHLIESILARDFHIKRPFIISVFELYLCAFGIYLGRFLRWNSWDIVLHGRTILSDIGIRVIRPVFYVDTWMFVFFFGTMLVLCYQSYRSFLTHTRNDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83081</accession>
    <name>Y039_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0039</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0039</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71373">
        <property type="entry name" value="F71373"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83081"/>
    <dbReference type="IntAct" id="O83081">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0039"/>
    <dbReference type="EnsemblBacteria" id="AAC65040">
        <property type="protein sequence ID" value="AAC65040"/>
        <property type="gene ID" value="TP_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0039"/>
    <dbReference type="HOGENOM" id="CLU_2959488_0_0_12"/>
    <dbReference type="OMA" id="NKPRQQF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202180" description="Uncharacterized protein TP_0039">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="52" mass="5934" checksum="6C4C8666A4E85EA1" modified="1998-11-01" version="1">MRQENKPCQQFYFVLDEKALQSPLRENPSKNVRTIPDAGDENSSFGHARVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83083</accession>
    <name>O83083_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Soluble lytic transglycosylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71374">
        <property type="entry name" value="B71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881492.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83083">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0043"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65037">
        <property type="protein sequence ID" value="AAC65037"/>
        <property type="gene ID" value="TP_0043"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75263">
        <property type="protein sequence ID" value="AGN75263"/>
        <property type="gene ID" value="TPANIC_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0043"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.39"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022873_0_0_12"/>
    <dbReference type="OMA" id="QRDACIW"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="549"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="710" mass="81751" checksum="2FE3C11A9E67A987" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83094</accession>
    <name>Y055_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0055</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0055</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71373">
        <property type="entry name" value="A71373"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881504.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83094"/>
    <dbReference type="SMR" id="O83094"/>
    <dbReference type="IntAct" id="O83094">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0055"/>
    <dbReference type="EnsemblBacteria" id="AAC65053">
        <property type="protein sequence ID" value="AAC65053"/>
        <property type="gene ID" value="TP_0055"/>
    </dbReference>
    <dbReference type="GeneID" id="57878596"/>
    <dbReference type="KEGG" id="tpa:TP_0055"/>
    <dbReference type="eggNOG" id="COG3630">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168750_0_0_12"/>
    <dbReference type="OMA" id="MTIAEMF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01195">
        <property type="entry name" value="oadG_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202182" description="Uncharacterized protein TP_0055">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="78" mass="7934" checksum="AEDCD20DBDBAE5A4" modified="1998-11-01" version="1">MNQIRLFAQSALVSVMGMGMVFAFLLLLICVVRCVGALVSSFGWDRGPDEGVGAAVPAGGALAAAIAVAVHEKARSTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83108</accession>
    <name>Y069_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0069</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0069</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71371">
        <property type="entry name" value="E71371"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83108"/>
    <dbReference type="STRING" id="243276.TPANIC_0069"/>
    <dbReference type="EnsemblBacteria" id="AAC65066">
        <property type="protein sequence ID" value="AAC65066"/>
        <property type="gene ID" value="TP_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0069"/>
    <dbReference type="eggNOG" id="ENOG5032FZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130453_0_0_12"/>
    <dbReference type="OMA" id="MNDANRF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202185" description="Uncharacterized protein TP_0069">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <sequence length="176" mass="19197" checksum="C367DFC9E5602A59" modified="1998-11-01" version="1">MCSFSTSVLCGPFQAVTYSAHAGAVCQTLGIVFSRSEHSTPSVCADAFSMKVRGIPVLQRRTWALVLLVLSSTSACVRKNSLEDVRFPSSSPIGEARRFAVITKAYVLLRDKPGVTGIVIAYARRKDIFPVLGIDLLSKDKESALWVNVERGWLPWDCVQLYSSKAKALAASKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83136</accession>
    <name>O83136_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat-shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71366">
        <property type="entry name" value="F71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881547.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65093">
        <property type="protein sequence ID" value="AAC65093"/>
        <property type="gene ID" value="TP_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0098"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.109"/>
    <dbReference type="HOGENOM" id="CLU_1277153_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="216" mass="24122" checksum="1B6568A634480FC8" modified="1998-11-01" version="1">MSERTVPDHYAILGVAADASEEHIKKAFRAQALKYHPDKNPGDACAEDQFKRINAAYAVLSDRASRARYDAERAGGAFWSSRAGRDASEGFGAWTSRYGRQGRSAHPLHTHARSLERARAGNRTLRGMVHFLRWFSWKWVELLEQCRRSARSGGSYRAHGLQERRGAPSHSGSGARPPGSIRATLLFSIWLLRDRIQRVLPGARSAHPEGRTLNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83144</accession>
    <name>O83144_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carnitine transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71365">
        <property type="entry name" value="G71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881555.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83144">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0106"/>
    <dbReference type="EnsemblBacteria" id="AAC26554">
        <property type="protein sequence ID" value="AAC26554"/>
        <property type="gene ID" value="TP_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0106"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.117"/>
    <dbReference type="eggNOG" id="COG1292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010118_6_0_12"/>
    <dbReference type="OMA" id="VHAWAIY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC26554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="510" mass="56167" checksum="C46878A27910AC72" modified="1998-11-01" version="1">MQKEKCDFSVSLIPLGIVISCALLFISFPDISHRVIGTLLNILVNKLGFFYILTGLFFLGTTLTIAFSRYGAVYLGTTRTARYSNFTWGSMIFTSTMAADILYWSLIEWAHYFTQAPFIAEHSPPTERQEWAAAYPLFHWGIIPWSFYVLLAVAFGYMLHVKKRHTHKISEACRPLLGAYVDGIIGEAIDICSVVGLLLGVATTFSLATPLLSLMVSLLFGISNTQLLALALLCVIALVYTTAVLLGTQGISKLSRAAVYCFSTVLVFFLCAGPTVYLIETGITAIGKMLQNFFLMATWMDPSRISLQETDGTLGFPQRWTIFYWAYWITWSVATPFFIGAISEGRTIRNTIVGGLCWGIAGTYGSFIVLGNYGLYLQTHHLLPAAYFVRAGNTPAEVIIAIIQTLPCAYIVMALLAATMIAFYASTFDALTLIIASYSQKSVAPGEEPRQIMKSFWAVACILLPASLIFSQSTLMHLKSLAIIAAFPLALIMLCVVASFFKELRAEVTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83148</accession>
    <name>Y110_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0110</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0110</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71364">
        <property type="entry name" value="E71364"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881559.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83148"/>
    <dbReference type="SMR" id="O83148"/>
    <dbReference type="IntAct" id="O83148">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65108">
        <property type="protein sequence ID" value="AAC65108"/>
        <property type="gene ID" value="TP_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0110"/>
    <dbReference type="eggNOG" id="ENOG5033U21">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034372_0_0_12"/>
    <dbReference type="OMA" id="RDHEDAF"/>
    <dbReference type="OrthoDB" id="906948at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035196">
        <property type="entry name" value="DUF5312"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17239">
        <property type="entry name" value="DUF5312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202190" description="Uncharacterized protein TP_0110">
        <location>
            <begin position="1"/>
            <end position="577"/>
        </location>
    </feature>
    <sequence length="577" mass="65150" checksum="55735A7173C3FF98" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83174</accession>
    <name>Y138_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0138</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0138</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71360">
        <property type="entry name" value="D71360"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881586.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83174"/>
    <dbReference type="SMR" id="O83174"/>
    <dbReference type="STRING" id="243276.TPANIC_0138"/>
    <dbReference type="EnsemblBacteria" id="AAC65139">
        <property type="protein sequence ID" value="AAC65139"/>
        <property type="gene ID" value="TP_0138"/>
    </dbReference>
    <dbReference type="GeneID" id="57878680"/>
    <dbReference type="KEGG" id="tpa:TP_0138"/>
    <dbReference type="eggNOG" id="ENOG5031CP2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093904_0_0_12"/>
    <dbReference type="OMA" id="ISMIDIP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202199" description="Uncharacterized protein TP_0138">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="245" mass="26965" checksum="7F19EE7704E17774" modified="1998-11-01" version="1">MQPPRPACQDEGTHGKEVCMLLIQKKRLLVVLIVSFLSILFSAGYAFRIGMLHAHKGSAETILFYGFVAAAFHFILSLYLMLHAHHKKKELLKLADMLRYGGSIGESHFKKFGVLGTQIQFLLKELLALSAQKSLKIAALSGLQRALTELIPTPVIIIDLNGTILDMTKGARKRVQRADKTLTIEHIFPATDSTRAVQEAEKTHTPVEQEGGIVFIPVFSAVGNISHFLVDISKQPASDEPLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83175</accession>
    <name>O83175_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71360">
        <property type="entry name" value="E71360"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881587.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0139"/>
    <dbReference type="EnsemblBacteria" id="AAC65127">
        <property type="protein sequence ID" value="AAC65127"/>
        <property type="gene ID" value="TP_0139"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75359">
        <property type="protein sequence ID" value="AGN75359"/>
        <property type="gene ID" value="TPANIC_0139"/>
    </dbReference>
    <dbReference type="GeneID" id="57878681"/>
    <dbReference type="KEGG" id="tpa:TP_0139"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.144"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_2_12"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="230" mass="25323" checksum="B04D6EA014516236" modified="1998-11-01" version="1">MAVKRNFAVVGLGAFGYRVCEVLVQGGGSVVAIDNNAQTVEKVKKVVSVAILIDTTSETELMKAPLDDVDVAIVAIGTNLQASILTTALLKQRDIPYILARATSPIHETILRKIGANEILNIEVASATTIAKRLVAPDVTDAIAMTDDISLREIVAPRFFTDKTLEELELREKFNVKIVAVVRTDMDIDPTGNSLPKKNIYYPDNAFTFRRADRMFVLGHNRDLRELTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>O83178</accession>
    <name>O83178_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71360">
        <property type="entry name" value="H71360"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881590.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83178">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0142"/>
    <dbReference type="EnsemblBacteria" id="AAC65130">
        <property type="protein sequence ID" value="AAC65130"/>
        <property type="gene ID" value="TP_0142"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75362">
        <property type="protein sequence ID" value="AGN75362"/>
        <property type="gene ID" value="TPANIC_0142"/>
    </dbReference>
    <dbReference type="GeneID" id="57878684"/>
    <dbReference type="KEGG" id="tpa:TP_0142"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.147"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="RPDSGAY"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="220" mass="24066" checksum="097861150CFCCDA2" modified="1998-11-01" version="1">MDNRPYVVVQELTKVWEEKRISLSFSLRQGTSLALLGASGCGKSTILKMIAGLITPDHGSVFIAGTNVTHWAPARRRIGMICQDFALFPHLSLEDNIGYGLVSQGLTKKTARVHAREWMARFGLQNMETRSVTTLSHGEKQRVALARSLAVRPALILFDEALSAIDADLRTTLQGELRALQRSLGYTAVYVTHDSTEAAALADTVIHMRTQPPLAAAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83190</accession>
    <name>O83190_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="A71359"/>
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        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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    <dbReference type="IntAct" id="O83190">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0155"/>
    <dbReference type="EnsemblBacteria" id="AAC65145">
        <property type="protein sequence ID" value="AAC65145"/>
        <property type="gene ID" value="TP_0155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75374">
        <property type="protein sequence ID" value="AGN75374"/>
        <property type="gene ID" value="TPANIC_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0155"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.162"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_0_12"/>
    <dbReference type="OMA" id="LFEINGC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
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    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="371" mass="40665" checksum="8BB00C5E5E3A82A8" modified="1998-11-01" version="1">MSVYCRSSKQTVREPCRPVPVGALLLFVTLLLLALALAYFGAQVEPLTPALTLTEQEPRQASGYVSSLLRARIVQEDAEPALYYTVYEVREGDVVGRIAQRYDISQDAIISLNKLRSTRALQVGQLLKIPSVDGILYTVKNGDTFSSIAAAHQISLERLVLLNTPSSSKESPPSVRTLVSPFYNSAARESCVPFPFSSAKQWRENTSFDAVQPLQPARVLFLPGAHLSARALQEINGDLFRAPLRSRYYVSSRYGWRSDPFTGARSFHNGLDMVSRRGTPVYSALGGIVRTVGYSAVYGNYLIVGHHAGYQTLYGHLQTVLVSAGTRVTSATKIGLLGKTGRSTGPHLHFTIYKNGSAINPTSLLRMRTLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83202</accession>
    <name>Y172_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0172</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0172</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71358">
        <property type="entry name" value="A71358"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881619.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83202"/>
    <dbReference type="SMR" id="O83202"/>
    <dbReference type="EnsemblBacteria" id="AAC65162">
        <property type="protein sequence ID" value="AAC65162"/>
        <property type="gene ID" value="TP_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0172"/>
    <dbReference type="HOGENOM" id="CLU_1531865_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202204" description="Uncharacterized protein TP_0172">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <sequence length="175" mass="19544" checksum="05BB08483DBFA0F4" modified="1998-11-01" version="1">MSDLEGLHLYNHSDEELFSIHDSVFQEHTGGEGRMSSSSGEEGCGQTLLPVHEKKSTYGLFNPLTGVGWRAYLEERLEAELGRATASEQDLTLMIVQVEHPAHQTAVADAAKKLVEFFKFRDMLFEFEGSCCFAGIVQDASLEERWYSRGIYTRSCAAPLRAHASLSASRRVRPD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83214</accession>
    <name>SSRP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">TP_0184</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65169" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65169.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71354">
        <property type="entry name" value="B71354"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881631.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83214"/>
    <dbReference type="SMR" id="O83214"/>
    <dbReference type="IntAct" id="O83214">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0184"/>
    <dbReference type="EnsemblBacteria" id="AAC65169">
        <property type="protein sequence ID" value="AAC65169"/>
        <property type="gene ID" value="TP_0184"/>
    </dbReference>
    <dbReference type="GeneID" id="57878722"/>
    <dbReference type="KEGG" id="tpa:TP_0184"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_12"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000103059" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="154" mass="17654" checksum="E30F37AF895A610D" modified="2000-05-30" version="2">MRGTGTHLIAKNRKAFFNYHVEDRLECGIALEGTEVKSVRAGHLSFPDAFAEMRGGELWLKNVHIAEYVHACSFAPNPDRMRKLLAHRDQIARLKRKVEEKGYTLVPLEFYLKAGRVKVALGICKGKKLFDKRAQIKARDNARELSRSLCERHH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83244</accession>
    <name>Y214_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0214</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0214</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71352">
        <property type="entry name" value="D71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881662.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83244"/>
    <dbReference type="IntAct" id="O83244">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0214"/>
    <dbReference type="EnsemblBacteria" id="AAC65210">
        <property type="protein sequence ID" value="AAC65210"/>
        <property type="gene ID" value="TP_0214"/>
    </dbReference>
    <dbReference type="GeneID" id="57878752"/>
    <dbReference type="KEGG" id="tpa:TP_0214"/>
    <dbReference type="eggNOG" id="ENOG5033FN4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194677_0_0_12"/>
    <dbReference type="OMA" id="KICKFCK"/>
    <dbReference type="OrthoDB" id="2035755at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202213" description="Uncharacterized protein TP_0214">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <sequence length="65" mass="7005" checksum="8D5D557C07814BE4" modified="1998-11-01" version="1">MSKAHRGKGIRGMVGRGRGVCPVTGQTGVKLLYECEIDGKKVKVSKVGRATLQNRKRRLDAQPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83249</accession>
    <name>O83249_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71353">
        <property type="entry name" value="A71353"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881668.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0220"/>
    <dbReference type="EnsemblBacteria" id="AAC65207">
        <property type="protein sequence ID" value="AAC65207"/>
        <property type="gene ID" value="TP_0220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75434">
        <property type="protein sequence ID" value="AGN75434"/>
        <property type="gene ID" value="TPANIC_0220"/>
    </dbReference>
    <dbReference type="GeneID" id="57878758"/>
    <dbReference type="KEGG" id="tpa:TP_0220"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.224"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_14_1_12"/>
    <dbReference type="OMA" id="YTITELQ"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="108" mass="11770" checksum="4804E8DF13617A8B" modified="1998-11-01" version="1">MDNINIAKDVRPGCVLLTVTGAVSSYTYGEFESRVHGALKENHVVLDLSGVTAMSSSGLGVLISAYDEGLKYQRRLCILNPSESVRRAIELTGFSEMFTVIKSLDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83252</accession>
    <name>O83252_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase (TpaaT)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71350">
        <property type="entry name" value="E71350"/>
    </dbReference>
    <dbReference type="IntAct" id="O83252">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0223"/>
    <dbReference type="EnsemblBacteria" id="AAC65212">
        <property type="protein sequence ID" value="AAC65212"/>
        <property type="gene ID" value="TP_0223"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75437">
        <property type="protein sequence ID" value="AGN75437"/>
        <property type="gene ID" value="TPANIC_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0223"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.227"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052346_1_0_12"/>
    <dbReference type="OMA" id="VWGFRVG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="36"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="435" mass="47305" checksum="A6E076CCB979FCDB" modified="1998-11-01" version="1">MRAPDMNGAVGMVLRHGVPVLRDTLHALVPDLSSSEIVSYAPTAGIPALRERWARRLCARDPVLCPDEPDVAAMQSAAEQGEHSCAAVFPKMSLPIVLPGLTAALSCAMDLFVGAGQTVLVPAPRWENYDLMLAVRCAATPVPFSLFRAGRFDLSACKEALDAQASDGVIRLILNFPHNPSGYTPTEEEAQQLYEVVYAYADAGCAVLVICDDAYSGFEYEASLMRGSFFARFAQAHKNICALKIDGLTKEEYAWGLRVGFLSCAGLALGVSQYQAFEKKVMGMIRASLSCTATLTQTLALRLLAEEDEPAGLGSATARERHQFFQLMCARYREVQRVVRDLTWSTTECGAAVPLRVEFLPCNSGYFTCIRCIGFSAETLRQYLLEQCGIGTVAIDEQHLRVAFSALELPAIERVLRAVVHTAVQLSCVGEGSRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83271</accession>
    <name>RS12_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsL</name>
        <name type="ordered locus">TP_0243</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Because the enzyme that would modify Asp-89 to 3-methylthioaspartic acid has not been found in the proteome of this organism, that modification is not predicted.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71347">
        <property type="entry name" value="F71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881691.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83271"/>
    <dbReference type="SMR" id="O83271"/>
    <dbReference type="IntAct" id="O83271">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0243"/>
    <dbReference type="EnsemblBacteria" id="AAC65232">
        <property type="protein sequence ID" value="AAC65232"/>
        <property type="gene ID" value="TP_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="57878785"/>
    <dbReference type="KEGG" id="tpa:TP_0243"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_12"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000146346" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="124" mass="13677" checksum="D1503C15AD51EB82" modified="1998-11-01" version="1">MPTINQLTRIGRKAVFSRTKSPALQACPQKRGVCTRVMTVTPKKPNSALRKVARVRLSSGVEVTAYIPGIGHNLQEHSIVLIRGGRVKDLPGVRYHIIRGAKDTLGVVDRKRGRSKYGAKRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83287</accession>
    <name>O83287_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71347">
        <property type="entry name" value="D71347"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881712.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65250">
        <property type="protein sequence ID" value="AAC65250"/>
        <property type="gene ID" value="TP_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0263"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.283"/>
    <dbReference type="HOGENOM" id="CLU_038154_0_0_12"/>
    <dbReference type="OMA" id="ENEWRHH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="489"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="594" mass="65845" checksum="D92B3E9FFAE0A805" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>O83302</accession>
    <name>Y278_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0278</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0278</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71343">
        <property type="entry name" value="A71343"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83302"/>
    <dbReference type="EnsemblBacteria" id="AAC65276">
        <property type="protein sequence ID" value="AAC65276"/>
        <property type="gene ID" value="TP_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0278"/>
    <dbReference type="HOGENOM" id="CLU_3259312_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202223" description="Uncharacterized protein TP_0278">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <sequence length="42" mass="4831" checksum="C36DED1C42B017C7" modified="1998-11-01" version="1">MRARLCQESALDSFLSMRLDGGGHWGRCRRAPDPLWEEQDIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83304</accession>
    <name>Y280_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0280</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0280</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71343">
        <property type="entry name" value="C71343"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83304"/>
    <dbReference type="IntAct" id="O83304">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65277">
        <property type="protein sequence ID" value="AAC65277"/>
        <property type="gene ID" value="TP_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0280"/>
    <dbReference type="HOGENOM" id="CLU_3334258_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202224" description="Uncharacterized protein TP_0280">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <sequence length="42" mass="4398" checksum="FB3DA7776545872E" modified="1998-11-01" version="1">MSGSVCCACDTRFFRAQWVDCGFGGSSSVVVGASPQGLLRVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83308</accession>
    <name>Y284_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0284</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0284</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71343">
        <property type="entry name" value="G71343"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881733.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83308"/>
    <dbReference type="IntAct" id="O83308">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65280">
        <property type="protein sequence ID" value="AAC65280"/>
        <property type="gene ID" value="TP_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0284"/>
    <dbReference type="HOGENOM" id="CLU_1260991_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202226" description="Uncharacterized protein TP_0284">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <sequence length="219" mass="23561" checksum="FECF4E84D50227C3" modified="1998-11-01" version="1">MRADKGAVGTVAVVCAFDLSDYAFVPLCGTREQSCMKAVPGFVPCVEVRGCESTAGVGRRCAFERAVTAAYALPGCHQVCVYADAASAAKVARFMQCATPIFPSLRVNVLDDMRVSAFFAHVARVCAEYAQLGEEPEAVFVLRADAPFIDSVASAQLYAQHREYLAEYSFADGYPEGLFAAVVAPGLFPILATLTQDAHICFALRSFLRALKQTLILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83320</accession>
    <name>O83320_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71341">
        <property type="entry name" value="C71341"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881746.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83320">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0297"/>
    <dbReference type="EnsemblBacteria" id="AAC65286">
        <property type="protein sequence ID" value="AAC65286"/>
        <property type="gene ID" value="TP_0297"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75502">
        <property type="protein sequence ID" value="AGN75502"/>
        <property type="gene ID" value="TPANIC_0297"/>
    </dbReference>
    <dbReference type="GeneID" id="57878834"/>
    <dbReference type="KEGG" id="tpa:TP_0297"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.298"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000922_0_0_12"/>
    <dbReference type="OMA" id="FWIQIAS"/>
    <dbReference type="OrthoDB" id="1321583at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="186"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="270" mass="29680" checksum="A8F43B62B758035F" modified="1998-11-01" version="1">MHSDAQGCFRRVNMEQKRILWIVISLSVFMLIIFGVALLLYSPTYSSNSAGVTDVSSYVERGDVPEHPSVDPSLWLKNPEKIPELGKTPAPTQRAIPDLTVVKDVPTARAKSLDVSPPARAERTDAAQDRKTSPASDTRESAESKGASKHARSDRASAKSPPATRTRAPLVAQRDARVRGASTQPAAPSVLFWVQAASLSSKLNAERARGVLAARHMKAEIFTKRTGAGLRHRVRVGPFTNRTEAVYWMKSIREIAEFSGCYVFQERVKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-19" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83327</accession>
    <name>PYRG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">TP_0305</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71342">
        <property type="entry name" value="C71342"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881754.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83327"/>
    <dbReference type="SMR" id="O83327"/>
    <dbReference type="IntAct" id="O83327">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0305"/>
    <dbReference type="EnsemblBacteria" id="AAC65292">
        <property type="protein sequence ID" value="AAC65292"/>
        <property type="gene ID" value="TP_0305"/>
    </dbReference>
    <dbReference type="GeneID" id="57878841"/>
    <dbReference type="KEGG" id="tpa:TP_0305"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_12"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138244" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="333"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="424"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="577" mass="62147" checksum="AFAD747EA85932D2" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83332</accession>
    <name>O83332_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71339">
        <property type="entry name" value="H71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881759.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0310"/>
    <dbReference type="EnsemblBacteria" id="AAC65303">
        <property type="protein sequence ID" value="AAC65303"/>
        <property type="gene ID" value="TP_0310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75514">
        <property type="protein sequence ID" value="AGN75514"/>
        <property type="gene ID" value="TPANIC_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0310"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.328"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_0_12"/>
    <dbReference type="OMA" id="HVEFRPE"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="127" mass="13784" checksum="EF8A66B0F5782E5F" modified="1998-11-01" version="1">MAAICPSSTAKAGGGGISVDPLNAVIVEGNVVPSASARVPEAAVCAFCIQTQRRVQGEGRVHTEVSYFEVEAWDALARVCAQQVRPGVGLRVVGRLKQDRWQQEDGVRVQRVKIVAEHVEFQTPFVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83336</accession>
    <name>Y314_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0314</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0314</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71340">
        <property type="entry name" value="D71340"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83336"/>
    <dbReference type="IntAct" id="O83336">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65305">
        <property type="protein sequence ID" value="AAC65305"/>
        <property type="gene ID" value="TP_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0314"/>
    <dbReference type="HOGENOM" id="CLU_3159005_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202232" description="Uncharacterized protein TP_0314">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <sequence length="48" mass="5442" checksum="4E3F073EF3884C04" modified="1998-11-01" version="1">MPVQLGVQHYFSAHWGIDATATVSFGIDTKLAKFRIPYTLRFGPVFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83342</accession>
    <name>O83342_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose/galactose ABC transporter, permease protein (RbsC-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71338">
        <property type="entry name" value="E71338"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881770.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83342">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0322"/>
    <dbReference type="TCDB" id="3.A.1.2.10">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65310">
        <property type="protein sequence ID" value="AAC65310"/>
        <property type="gene ID" value="TP_0322"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75522">
        <property type="protein sequence ID" value="AGN75522"/>
        <property type="gene ID" value="TPANIC_0322"/>
    </dbReference>
    <dbReference type="GeneID" id="57878854"/>
    <dbReference type="KEGG" id="tpa:TP_0322"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.321"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_1_12"/>
    <dbReference type="OMA" id="FRMNLFN"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="400" mass="42563" checksum="39386B40AADBD14D" modified="1998-11-01" version="1">MRRNRARARASHEWDAEKRDCGQKNRGTGVIARLRGCLVHPKYHALLIPCLAVILGFAVGAVVMAVSGLHPKYILIALVRSMFGVNVQAFGTGRSVWNFRYMGEGVVTCLPLILTGLAVAFTSHMGLFNIGAEGQLVVGSVCAVCVGVLWHEHLSFFTIPAAVLAGMVGGGLWGLIPGVLRAVCGISEVVVTIMLNYVGLYGANFVVTALPGSDLMRTVSLPPAATLHSDFLSRVSNGSRLHWGFLLVIAALVSFKFLIEKTTFGYELRVVGASAEAARYAGIHIRRRVMLATSISGMYAGLAGVLLAIGTFSYGRVLPGFEGYGFEGIVVSLVGRNTAWGCVFGGSLLGSLRAAGPLMQLNGVPKEVSVIIVSAIIVFLSMHNGIRAMLVRWGRQGAHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83349</accession>
    <name>GLYA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="1">SHMT</shortName>
            <shortName evidence="1">Serine methylase</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyA</name>
        <name type="ordered locus">TP_0329</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71336">
        <property type="entry name" value="G71336"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83349"/>
    <dbReference type="SMR" id="O83349"/>
    <dbReference type="IntAct" id="O83349">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0329"/>
    <dbReference type="EnsemblBacteria" id="AAC65317">
        <property type="protein sequence ID" value="AAC65317"/>
        <property type="gene ID" value="TP_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0329"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_12"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000113687" description="Serine hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="1">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <sequence length="574" mass="62689" checksum="3C6969C42195A2B2" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83368</accession>
    <name>O83368_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71336">
        <property type="entry name" value="C71336"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0348"/>
    <dbReference type="EnsemblBacteria" id="AAC65339">
        <property type="protein sequence ID" value="AAC65339"/>
        <property type="gene ID" value="TP_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0348"/>
    <dbReference type="eggNOG" id="COG4769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044846_0_0_12"/>
    <dbReference type="OMA" id="IWVAAPL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="469" mass="50956" checksum="3160DDD8095276C0" modified="1998-11-01" version="1">MRLVRSRLPLDVRDELVSLLGGMCFFLSTVEHVIPKPLPFFRVGLANLPLLISPDLLPFCAYARLVFLKVIGQALVSGTLFSYVFVLSLAGSTASGALMYALRFVPCRYLSCVGISVMGAFCSNVIQLTLARVLVFGAGVWYVLPLFCALGAVSSTLLGALTGHFLSHSQWYAHLQNAACGQQDTAPPASLFFPVQAGCECTAPCSEHGLRPRVLRYVRMGTGLLLLLILLCVPRLSVQASVCGIALLLYAATGGRIRWMTLAGLWVGTLACYLRPPVGRVWATVLGVPLTSGALSAGARQACMASGMVYLSKWILRVPPHLPGKFGQTVVHALSLMHRLSSFKCAAHDGTLHKKSTAFFSRSGQLDSGRQRAAKSAPPRTLYSKGRTGPQRDRENETTRGVAQKVIHRLLRNPSALRHNPTESLGNNGQSEGNKPAQIQCLDNPFANKLLPQRNERHALHRFCRQLTC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83371</accession>
    <name>Y352_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0352</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0352</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71333">
        <property type="entry name" value="F71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881800.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83371"/>
    <dbReference type="SMR" id="O83371"/>
    <dbReference type="IntAct" id="O83371">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0352"/>
    <dbReference type="EnsemblBacteria" id="AAC65352">
        <property type="protein sequence ID" value="AAC65352"/>
        <property type="gene ID" value="TP_0352"/>
    </dbReference>
    <dbReference type="GeneID" id="57878882"/>
    <dbReference type="KEGG" id="tpa:TP_0352"/>
    <dbReference type="eggNOG" id="COG4443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180137_1_0_12"/>
    <dbReference type="OMA" id="KFDIRDW"/>
    <dbReference type="OrthoDB" id="2012036at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017154">
        <property type="entry name" value="PC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037246">
        <property type="entry name" value="UCP037246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202239" description="Uncharacterized protein TP_0352">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <sequence length="85" mass="9663" checksum="99C49EB0EC964ADA" modified="1998-11-01" version="1">MREKEGGVVNDDFHYEVTRNWGTLSTSGNGWSLELKSISWNGRPEKYDIRAWSPDKSKMGKGVTLTRAEIVALRDLLNSMSLDPY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>O83378</accession>
    <name>Y359_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0359</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0359</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71334">
        <property type="entry name" value="E71334"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881807.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83378"/>
    <dbReference type="SMR" id="O83378"/>
    <dbReference type="IntAct" id="O83378">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0359"/>
    <dbReference type="EnsemblBacteria" id="AAC65354">
        <property type="protein sequence ID" value="AAC65354"/>
        <property type="gene ID" value="TP_0359"/>
    </dbReference>
    <dbReference type="GeneID" id="57878888"/>
    <dbReference type="KEGG" id="tpa:TP_0359"/>
    <dbReference type="eggNOG" id="COG3330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100589_0_0_12"/>
    <dbReference type="OMA" id="RSWYINI"/>
    <dbReference type="OrthoDB" id="1711249at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032585">
        <property type="entry name" value="DUF4912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16258">
        <property type="entry name" value="DUF4912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202241" description="Uncharacterized protein TP_0359">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <sequence length="211" mass="23888" checksum="91FFE8B24C630327" modified="1998-11-01" version="1">MALTKSFLESRSTGELFALADELGLCLPEDLNRRLVIGEILDCYHSALDLNPPCAPQSLESKGTSCAYNTTEIHILARDPLWFFVFWDIHEQLFCTLTQSPQFRSFFLRVHSLGGHGWHTSLDHFDIDVPLKDRKRYVHLSLADDANRIDLCCKMLQRERILAQSRVVTLQRSVIERSLNPEDPTGAEVLSLCGLPLLEETYPSTSLPVCS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83391</accession>
    <name>Y376_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0376</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0376</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71330">
        <property type="entry name" value="B71330"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881824.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83391"/>
    <dbReference type="SMR" id="O83391"/>
    <dbReference type="IntAct" id="O83391">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65381">
        <property type="protein sequence ID" value="AAC65381"/>
        <property type="gene ID" value="TP_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0376"/>
    <dbReference type="HOGENOM" id="CLU_072078_0_0_12"/>
    <dbReference type="OMA" id="FYNIDIV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014247" description="Uncharacterized protein TP_0376">
        <location>
            <begin position="29"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="301" mass="33685" checksum="AE4D0CF255EE0A25" modified="1998-11-01" version="1" precursor="true">MFFREDKSVAFRLRSAALSGCATGQSDAVTDPLSVLEVSQTETREALMLFVSYNETGASVTIFTPELVARLSKSYRFLRVEAPHSAYTLSPEARERNRLLFSEYEVDGLPFLVLQSAQGDAYFAQRIHSTLSSEQELWALIRSADASRKKVLAARDRIAQTEAAEKAIAIDAFLKTVRYPRSARYDALRKEALQADHENVSGLHGDYMFHLARRRAEKFIKQENLVAAGNAYKDLAQSPFLSASQKQEAWYLTAYTYALSEKVSTEDVVACLRKAVAAHPHAARVAQIKQTIKKLLTERGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83433</accession>
    <name>GAL1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative galactokinase</fullName>
            <ecNumber>2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">galK</name>
        <name type="ordered locus">TP_0418</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71327">
        <property type="entry name" value="H71327"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83433"/>
    <dbReference type="SMR" id="O83433"/>
    <dbReference type="IntAct" id="O83433">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0418"/>
    <dbReference type="EnsemblBacteria" id="AAC65405">
        <property type="protein sequence ID" value="AAC65405"/>
        <property type="gene ID" value="TP_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0418"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_12"/>
    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0299">Galactose metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184634" description="Putative galactokinase">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="397" mass="45255" checksum="A86D102B89C6FB6C" modified="1998-11-01" version="1">MLYYFNTLAMMLRMQRVESCHTEEYGDEPEAIAVVPGRFHLLGEYLWFAQGNTLSMAIDQTLTLCVSRRKDSTFRLFSLTLGERRKISTANLRYRKEDRWANSVKAVILSFMDGGYHLTGLNCTILSQIPPDAGLGTPNALKVAMALVLGRLFAATLPKESVVSIVEHANERYLKTHAHRADILCVLFAKQGSCVRTDHRKKQAELCQFPSEGKRIVLTDSRVPRFIAREEFTARLKRCVDAYELVKRNPDMPRAMSKLMAAALEEIDVPEGIRRRVISLVRESLGVDEAIEALRKRDFAAFSRVVNRSHERLRDRFEISCPELDWLVKRALEFVDPDAPDVVCSRLTGRGFGGCTYAILRDQDFEPYLERLDEYERIFGFKAAAYEVQCSEGARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83436</accession>
    <name>O83436_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71325">
        <property type="entry name" value="B71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881869.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83436"/>
    <dbReference type="IntAct" id="O83436">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0421"/>
    <dbReference type="EnsemblBacteria" id="AAC65409">
        <property type="protein sequence ID" value="AAC65409"/>
        <property type="gene ID" value="TP_0421"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75615">
        <property type="protein sequence ID" value="AGN75615"/>
        <property type="gene ID" value="TPANIC_0421"/>
    </dbReference>
    <dbReference type="GeneID" id="57878946"/>
    <dbReference type="KEGG" id="tpa:TP_0421"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.420"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025265_0_0_12"/>
    <dbReference type="OMA" id="FKWALNS"/>
    <dbReference type="OrthoDB" id="81633at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007697218" evidence="4">
        <location>
            <begin position="27"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="227"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="683" mass="74519" checksum="F91407FA7094AAD1" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83438</accession>
    <name>O83438_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71325">
        <property type="entry name" value="D71325"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881871.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0423"/>
    <dbReference type="EnsemblBacteria" id="AAC65410">
        <property type="protein sequence ID" value="AAC65410"/>
        <property type="gene ID" value="TP_0423"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75617">
        <property type="protein sequence ID" value="AGN75617"/>
        <property type="gene ID" value="TPANIC_0423"/>
    </dbReference>
    <dbReference type="GeneID" id="57878948"/>
    <dbReference type="KEGG" id="tpa:TP_0423"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.422"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038037_0_0_12"/>
    <dbReference type="OMA" id="RMIDKIT"/>
    <dbReference type="OrthoDB" id="1010640at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30084" checksum="994341CD8813F722" modified="1998-11-01" version="1">MRVFVSWHKQKDKGERERAGALQGACIGTPEHRQVFALVGRSGSGKSFRAQIVMRRFDIAFVIDDGLLIREDKIIAGRSAKQERTLLAAIRVALFENTMHRRVVARVLTYFLCGSQNKKVLILGTSERMVRRIALRVGLPEPGHIIRIEDIASSEEIACALRTRHVEGTHVIPVPSGEVRKSYPKIFYERIKLLLRREAGAERIGRWAHAIWHEGLKRACSGAHAHVFEKSIVRPPFSCNLRVVAATEGTQDASPVVVPPHEELALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83445</accession>
    <name>O83445_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">V-type ATPase, subunit K (AtpK-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71326">
        <property type="entry name" value="C71326"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881878.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83445">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0430"/>
    <dbReference type="TCDB" id="3.A.2.3.3">
        <property type="family name" value="the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65416">
        <property type="protein sequence ID" value="AAC65416"/>
        <property type="gene ID" value="TP_0430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75624">
        <property type="protein sequence ID" value="AGN75624"/>
        <property type="gene ID" value="TPANIC_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0430"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.457"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126047_1_0_12"/>
    <dbReference type="OMA" id="IGAWKKC"/>
    <dbReference type="OrthoDB" id="1819847at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="140" mass="14188" checksum="0229A32583BE0155" modified="1998-11-01" version="1">MNFGMFGAAAVLGISAVGSALGLALAGQGTIGSWKRCYLNNKPAPFILLAFAGAPLTQTIYGFLLMKAMFSSEKDPWYLLGAGVACGLGIAASALSQGRAAAAGADALAETGKGFSQYLTIVGLCETVALLVMVFGIINC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83456</accession>
    <name>RECN_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">recN</name>
        <name type="ordered locus">TP_0442</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71324">
        <property type="entry name" value="B71324"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881890.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83456"/>
    <dbReference type="SMR" id="O83456"/>
    <dbReference type="STRING" id="243276.TPANIC_0442"/>
    <dbReference type="EnsemblBacteria" id="AAC65429">
        <property type="protein sequence ID" value="AAC65429"/>
        <property type="gene ID" value="TP_0442"/>
    </dbReference>
    <dbReference type="GeneID" id="57878966"/>
    <dbReference type="KEGG" id="tpa:TP_0442"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_12"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000188028" description="DNA repair protein RecN">
        <location>
            <begin position="1"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="573" mass="63571" checksum="9430825B901926E3" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83481</accession>
    <name>O83481_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71321">
        <property type="entry name" value="F71321"/>
    </dbReference>
    <dbReference type="IntAct" id="O83481">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65449">
        <property type="protein sequence ID" value="AAC65449"/>
        <property type="gene ID" value="TP_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0468"/>
    <dbReference type="HOGENOM" id="CLU_1524467_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19606" checksum="D41A925FF0C647FA" modified="1998-11-01" version="1">MLAAQKTGRVDLALTQYQLAAARDPAHVKAHNNLGKLYLDKGALQEAETHLQAALAHDAQNFEVNSNLGKLYVLRAQWETAIAHYRRAATAQPQDREAQCQVARVYVAAGQPHEALRAYRAVLAQDARAWDVYLEAGKLAIKVNEKEYAQEVLTQLLDRNPDYAQAPHVRQLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83509</accession>
    <name>O83509_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71316">
        <property type="entry name" value="D71316"/>
    </dbReference>
    <dbReference type="IntAct" id="O83509">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0496"/>
    <dbReference type="EnsemblBacteria" id="AAC65483">
        <property type="protein sequence ID" value="AAC65483"/>
        <property type="gene ID" value="TP_0496"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75686">
        <property type="protein sequence ID" value="AGN75686"/>
        <property type="gene ID" value="TPANIC_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0496"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.492"/>
    <dbReference type="eggNOG" id="COG2976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073066_0_0_12"/>
    <dbReference type="OMA" id="KSDLVLW"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="329" mass="37761" checksum="565B880F279D2589" modified="1998-11-01" version="1">MTESGLPVLCFFRVSMEFLLRRSGHQSFFPGRRKLPNSVFLFSVFFALVVGVGVGAWRYRRYYRGLPSARSVYEDWKNGNYKAVYDKAAEILQRRVFDAEMLALHGFAAYYIFSEQTDLSVSYDYLNSAIVSLRRALHVVRPAEVPNVSYVLGKAYYQRGYYYADLAVKYLDLAYNAGFRAADLAEFRGMSASLLGDMQKAVESFTQALAAQPSDLVLYALAECYEKLSDFSKAKLYLYDTIGKTKDVLLELKCRNRLAALYLSERNLAEAERELDVVLQKDERSAEAHYHRGVLYEMGSDLVRARAEWRRALRLNPLHEPTRVKLNLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83516</accession>
    <name>Y503_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0503</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0503</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71317">
        <property type="entry name" value="C71317"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881952.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83516"/>
    <dbReference type="IntAct" id="O83516">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0503"/>
    <dbReference type="EnsemblBacteria" id="AAC65492">
        <property type="protein sequence ID" value="AAC65492"/>
        <property type="gene ID" value="TP_0503"/>
    </dbReference>
    <dbReference type="GeneID" id="57879024"/>
    <dbReference type="KEGG" id="tpa:TP_0503"/>
    <dbReference type="eggNOG" id="ENOG503450S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118622_1_0_12"/>
    <dbReference type="OMA" id="MVINETP"/>
    <dbReference type="OrthoDB" id="1542115at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014252" description="Uncharacterized lipoprotein TP_0503">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="187" mass="21410" checksum="C96F2AE1D1C80A64" modified="1998-11-01" version="1" precursor="true">MYAGGRVVRSAFARGKVCYLIGSVLWGSVSCTQPRVQKWVQNDGKVNVHSPQERAGVVATFGTVRITRSDYERTKAELQDVVAHLNRITAERDYHKWLVYLSDAYRRAYSMPDILQQSSDALPKKGVRLRHLRDYFIHVFVPSRQNVRVDSIVFESPTRVDVIMNHGGKALLVYKIEKIHSAWKLLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83527</accession>
    <name>UVRA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein A</fullName>
            <shortName evidence="1">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrA</name>
        <name type="ordered locus">TP_0514</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71315">
        <property type="entry name" value="A71315"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881963.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83527"/>
    <dbReference type="SMR" id="O83527"/>
    <dbReference type="IntAct" id="O83527">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0514"/>
    <dbReference type="EnsemblBacteria" id="AAC65502">
        <property type="protein sequence ID" value="AAC65502"/>
        <property type="gene ID" value="TP_0514"/>
    </dbReference>
    <dbReference type="GeneID" id="57879037"/>
    <dbReference type="KEGG" id="tpa:TP_0514"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_12"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000093109" description="UvrABC system protein A">
        <location>
            <begin position="1"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="327"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="625"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="657"/>
            <end position="664"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <sequence length="960" mass="106010" checksum="32F78624B19F7ABF" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83538</accession>
    <name>O83538_TREPA</name>
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        <submittedName>
            <fullName evidence="7">ATP-dependent helicase (HrpA)</fullName>
        </submittedName>
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        <name evidence="7" type="ordered locus">TP_0526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
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            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-1585740">
            <id>O83538</id>
        </interactant>
        <interactant intactId="EBI-1585751">
            <id>O83862</id>
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        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
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    </dbReference>
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        <property type="protein sequence ID" value="AGN75714"/>
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    </dbReference>
    <dbReference type="GeneID" id="57879050"/>
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    <dbReference type="PATRIC" id="fig|243276.9.peg.522"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="207"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="668" mass="75453" checksum="B0209A1C981BCD92" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-24" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83540</accession>
    <name>VATB2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase beta chain 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>V-ATPase subunit B 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">atpB2</name>
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    </gene>
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        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
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                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65515">
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="875807at2"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144684" description="V-type ATP synthase beta chain 2">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="480" mass="53057" checksum="D02C999311D3EF92" modified="1998-11-01" version="1">MKGVWYRGLSSIDGPIVVAKRREGAFYGEITAIRDRFGALRTGRIIDLSQECCLIQVFGSTLGLSLDGACLEFLDVPMQLRVCEGLMGRVFDGLGRPIDGFPEVLSSQLRNVNGYPINPYARVYPRDFIQTGISAIDGMNTLIRGQKLPIFSGNGLAHNRLAAQIIRQAKILGTDEAFVMVFAGMGIKHDVARFFVSSFEETGVLSKVVMFLSLADAPSIERIITPRCALTAAEYLAFEKNKHVLVIFTDMTNYCEALREVSTTRGEVPGRKGYPGYLYSDLAELYERAGRVKGSSGSVTQIPILTMPNDDISHPIPDLTGYITEGQIVLQRDLSQRGLYPPIGCLPSLSRLMKDGIGEGMTRADHHAVSSQLFASYARVQSVRSLASIVGEEELPALDKCYLRFGDLFEQYFLTQDEHEDRSISQTLDIGWSLLSLLPRTELYRIDPKLIDQYLTASCSAVSDQLRKAIEEARTPVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83551</accession>
    <name>O83551_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71312">
        <property type="entry name" value="A71312"/>
    </dbReference>
    <dbReference type="IntAct" id="O83551">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0540"/>
    <dbReference type="EnsemblBacteria" id="AAC65524">
        <property type="protein sequence ID" value="AAC65524"/>
        <property type="gene ID" value="TP_0540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75727">
        <property type="protein sequence ID" value="AGN75727"/>
        <property type="gene ID" value="TPANIC_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0540"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.536"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_9_3_12"/>
    <dbReference type="OMA" id="NIEIETH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="123" mass="13599" checksum="5E75ABD0DB1EF1DD" modified="1998-11-01" version="1">MPMELKVRQSGGICVVDISGDMDLYHSYKLKDLVLKLFDRGPRCIVIDLEAVEYIDSSGIGVLIYLCSTVKKLKIHFFISGVHGSVKKVIELTRLLNYFPIAESVDEALARARSSAPPQTGSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-05-04" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83552</accession>
    <name>ERA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">era</name>
        <name type="ordered locus">TP_0541</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71312">
        <property type="entry name" value="B71312"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881988.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83552"/>
    <dbReference type="SMR" id="O83552"/>
    <dbReference type="IntAct" id="O83552">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0541"/>
    <dbReference type="EnsemblBacteria" id="AAC65525">
        <property type="protein sequence ID" value="AAC65525"/>
        <property type="gene ID" value="TP_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0541"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_12"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000180068" description="GTPase Era">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Era-type G" evidence="2">
        <location>
            <begin position="9"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="227"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <sequence length="319" mass="35742" checksum="3DCED9411D1F261A" modified="1998-11-01" version="1">MVTDGASPRSGVSLIIGRPSSGKSTFLNAVCGYKVSIVSPIPQTTRNTVRGIVNIESDQIVFMDTPGYHRSDRKFNLRLQSLVHSNVKDADVLLYLVDATRQFGEEEAAICALLAPYQKTRVLLAFNKVDVLHNSTSCDEHAFLHRQGSVLRAGSLGRALHAALPHLPADRVFTISALHQVGLDALMRTLRDLLPEAAPLYPQDCYTDQTIAFRVTELIREQAIARCRDELPHALYAGVEDMELRRGKRELWCRAFLAVERESQKAVLVGKKGAVIRAIRLDAIRALRTLLPYHISLDIRVKVDRSWRQRDHTLSSLLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83571</accession>
    <name>TKT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Transketolase</fullName>
            <shortName>TK</shortName>
            <ecNumber>2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">tkt</name>
        <name type="synonym">tktA</name>
        <name type="ordered locus">TP_0560</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71310">
        <property type="entry name" value="D71310"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882007.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0560"/>
    <dbReference type="EnsemblBacteria" id="AAC26564">
        <property type="protein sequence ID" value="AAC26564"/>
        <property type="gene ID" value="TP_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0560"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.600"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_12"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
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        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000191879" description="Transketolase">
        <location>
            <begin position="1"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="661" mass="71125" checksum="5FEA512DAFF15F44" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83593</accession>
    <name>Y584_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0584</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0584</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71307">
        <property type="entry name" value="F71307"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882030.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83593"/>
    <dbReference type="STRING" id="243276.TPANIC_0584"/>
    <dbReference type="EnsemblBacteria" id="AAC65560">
        <property type="protein sequence ID" value="AAC65560"/>
        <property type="gene ID" value="TP_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0584"/>
    <dbReference type="eggNOG" id="ENOG5033PNA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585163_0_0_12"/>
    <dbReference type="OMA" id="NQKRHEY"/>
    <dbReference type="OrthoDB" id="1121997at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202280" description="Uncharacterized protein TP_0584">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <sequence length="469" mass="53514" checksum="2C5DABC441DA89A2" modified="1998-11-01" version="1">MEERKNYMDRLAEALTRRKVQLDRDILPKALEQYRVQVTAVKAIRSNLLQKGFLHDDAYKYDSKMTEIELPETSPYGENEKPMVIGSRLSHYQTMLGFLDNYYRFDSEFLIPKRIAKLVALNGTFMWKDFTATTKDANTRGLFDIVQSFYGAADPISIGLVRDSLQYLVKAHEVISTALKSLSVFHRERYKLLIRQHALDGLDETTVDVNNPEVALDAMKKNFSENAKGHPFYSELATVVLREDFSANAEKLRAAILREFEESSAPKRCRGAMRNPHAVLLSGFRSLGATSSHFHTALEKIRFNEELVTQSEAAFFSKVVLAFLKAFNIQTRSKDVEIVVVDPATQIQKKECVNVELFQKELARCVKLYRGFVSPDTPIHEKLMALKDEQLFELLFKHVAEAHTLVKQLAGLDEYYKTVRSDVRAKIKGVKIEVTTITTSVTKANKCRAEYASQLEEQKHMKRLGVARA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83601</accession>
    <name>O83601_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M15_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71306">
        <property type="entry name" value="A71306"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882038.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83601">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0592"/>
    <dbReference type="EnsemblBacteria" id="AAC65570">
        <property type="protein sequence ID" value="AAC65570"/>
        <property type="gene ID" value="TP_0592"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75775">
        <property type="protein sequence ID" value="AGN75775"/>
        <property type="gene ID" value="TPANIC_0592"/>
    </dbReference>
    <dbReference type="GeneID" id="57879116"/>
    <dbReference type="KEGG" id="tpa:TP_0592"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.586"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_545050_0_0_12"/>
    <dbReference type="OMA" id="QSKERSY"/>
    <dbReference type="OrthoDB" id="1915613at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503437" description="Peptidase_M15_4 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="211"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="500" mass="58269" checksum="3B3686591AA673C6" modified="1998-11-01" version="1">MVFRRTVALALLLRTLPCAAHFGNRDRTFYDLNNAPLALRAIQDAYPHLNAVIAYDPREQDWLIRSDGRTLYWAEGRLLPREHRDQAHDWRPIIDYVYAREVLDPAHLFPEEIHALRPKTLAIKRSATKPYHDAFFTWLYGPATRSEINARLARDYTFLGKPVYVHKALITRLNAVQEKILTAAKTHAHVQKFIEDLLRVDGFNWREISDSRQKSNHSWGIALDLMPKNWQRHTMYWNWEAAHNEDWMHIPIKKRWAPPAEIISLFESEGFIWGGHWMLWDTMHFEYRPELLAVRKILAEGNRYDFQEQNIVVHADDFPAQYFSPKEVFGTDEKEHITYAESCVRATHASVKELVRARTLVARFSPMRRLHVYAPPESIHNSIDTALLRMTAQLKKNYTNAKIRNNSRLLSKKHAQTRASRRSADVYTVSCRHAQAIALQYPHALSWQSKERSDALWIALFSVRQEAARRSVCTPSSKEQCMTHALSSCVDLARTHILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83622</accession>
    <name>O83622_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71303">
        <property type="entry name" value="B71303"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882059.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0613"/>
    <dbReference type="EnsemblBacteria" id="AAC65589">
        <property type="protein sequence ID" value="AAC65589"/>
        <property type="gene ID" value="TP_0613"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75794">
        <property type="protein sequence ID" value="AGN75794"/>
        <property type="gene ID" value="TPANIC_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="57879136"/>
    <dbReference type="KEGG" id="tpa:TP_0613"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.605"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_2_0_12"/>
    <dbReference type="OMA" id="QANAWSS"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="382" mass="43025" checksum="0E53A7F8D4F66D85" modified="1998-11-01" version="1">MKKREFFKRLGYHAQDVASQPFSRTQVTSSSALVRSSSIEHFLCTEPERAARAFDFRTRDRQRHCGLGEAYVQEVKEKRNAGVYLSVPRTSETVHVLIRFTMDTHNRVLYDQTFLDIQEGARVKVLVCVDAQGYTPQDAPALVGPQALERAPFRNGLVSVQVGRGASVELIKVQNTHPTAVNFETVHLHAQESAQVRCYDVQIGAQISGVSNSAFLRDEWARVEIHPLYFIDKARRMDLEHNLIVEGKNSHAHICACGVVKDGARKTFRGNIFLHRGCSHSVARFSDRTILLDRTAVGVSIPTIFCDEDDVVGEHAASFETIGSDVLYYLMSRGLDEYGAKRLIIEAAFKPVFALIDDAHIRETLVRNFDESLDRAHRKRKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83626</accession>
    <name>Y617_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0617</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0617</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71303">
        <property type="entry name" value="F71303"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882063.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83626"/>
    <dbReference type="IntAct" id="O83626">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0617"/>
    <dbReference type="EnsemblBacteria" id="AAC65593">
        <property type="protein sequence ID" value="AAC65593"/>
        <property type="gene ID" value="TP_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0617"/>
    <dbReference type="HOGENOM" id="CLU_2439913_0_0_12"/>
    <dbReference type="OMA" id="KDEGAIC"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202288" description="Uncharacterized protein TP_0617">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <sequence length="92" mass="10318" checksum="7F678BFAAB304855" modified="1998-11-01" version="1">MCSFEHGGWYVPKTVLSLLRRRKCQDARAESEELGITGICQNYAVPVQLGVQHYFGAHWGIDATATVSFGVDTKLAKFRIPYTLRVGPVFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83632</accession>
    <name>O83632_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OmpA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2016" name="PLoS ONE" volume="11" first="e0166274" last="e0166274">
            <title>The Structure of Treponema pallidum Tp0624 Reveals a Modular Assembly of Divergently Functionalized and Previously Uncharacterized Domains.</title>
            <authorList>
                <person name="Parker M.L."/>
                <person name="Houston S."/>
                <person name="Wetherell C."/>
                <person name="Cameron C.E."/>
                <person name="Boulanger M.J."/>
            </authorList>
            <dbReference type="PubMed" id="27832149"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0166274"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 61-476</scope>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71302">
        <property type="entry name" value="A71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882070.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="PDB" id="5JIR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=61-476"/>
    </dbReference>
    <dbReference type="PDBsum" id="5JIR"/>
    <dbReference type="SMR" id="O83632"/>
    <dbReference type="IntAct" id="O83632">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0624"/>
    <dbReference type="EnsemblBacteria" id="AAC65597">
        <property type="protein sequence ID" value="AAC65597"/>
        <property type="gene ID" value="TP_0624"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75805">
        <property type="protein sequence ID" value="AGN75805"/>
        <property type="gene ID" value="TPANIC_0624"/>
    </dbReference>
    <dbReference type="GeneID" id="57879147"/>
    <dbReference type="KEGG" id="tpa:TP_0624"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.616"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609615_0_0_12"/>
    <dbReference type="OMA" id="IEHESIM"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="359"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="5JIR"/>
        </source>
    </evidence>
    <sequence length="476" mass="52741" checksum="4DDD16EC39E19122" modified="1998-11-01" version="1">MGVSCLTRAASFSNQCRFPFGALSLVWTHASAPHVVRSSARRFILLLLFVLFSHAPSGAQTQDAVHTDAVQDWKNGTINAQLTLDLARARMRLPADRTAASQFLRYKAPAQLKDVYLSVLVDSQNRVGDCLAHEKIRLADITALVDAGHHAVTTLSPSVRSLQLSHQTPLTALARLFVTHETAYVPAIPPTSAVSRPYTGILIDARGSLPVHGEYVSEPLSACLFPKIWSTDMDLIYEKNMVHPDRAKAWGVVRYGSVWDEKMYRDRIGTTPLKIIARGVFGQQRTDPIIASKDAAQILARPENLRLLAEGNVIILCDEAALRVHVPYPLVDEHFYFAYHDVKRFLTDERSPGVGVRSGINTLKITVYDVRFVANSPEILASEKDRVDVIATALKKMGPYTRFLIEGHTADLHRPQEEAALSVARAQRMAQELSRRGIEMTRITTAGHGATKPIAPSDTHANKAKNRRVEITILRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>O83651</accession>
    <name>Y645_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0645</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0645</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71299">
        <property type="entry name" value="D71299"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83651"/>
    <dbReference type="STRING" id="243276.TPANIC_0645"/>
    <dbReference type="EnsemblBacteria" id="AAC65626">
        <property type="protein sequence ID" value="AAC65626"/>
        <property type="gene ID" value="TP_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0645"/>
    <dbReference type="HOGENOM" id="CLU_2977935_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202294" description="Uncharacterized protein TP_0645">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <sequence length="58" mass="6438" checksum="FC96B074C7E69CD4" modified="1998-11-01" version="1">MRAVLTRTQFLFSLYRGSDHTVCQADASTHRMAVVCIRHCHLCGSVGCARGKCVLAWL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>O83671</accession>
    <name>Y665_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0665</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0665</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71298">
        <property type="entry name" value="B71298"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882110.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83671"/>
    <dbReference type="IntAct" id="O83671">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0665"/>
    <dbReference type="EnsemblBacteria" id="AAC65641">
        <property type="protein sequence ID" value="AAC65641"/>
        <property type="gene ID" value="TP_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0665"/>
    <dbReference type="eggNOG" id="ENOG502ZJ9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092314_0_0_12"/>
    <dbReference type="OMA" id="MINTYSE"/>
    <dbReference type="OrthoDB" id="1789644at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202297" description="Uncharacterized protein TP_0665">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="251" mass="28955" checksum="8A8856D0CCE6C3DB" modified="1998-11-01" version="1">MTINTCRETGLHRALKDYFSPRGSRQEVELRGSICDVVHPDGTIVEVQTSGLGRLEAKLKKLLPYHQVMVVYPVSRRLYIRMLNEDGSERHYRKSPKEGSFFQIYREIGRLHDLLDHEHLSLHIVYIHSEVIKVDDRKGRSRYKKPRIVDRKLLEVQSSEEFRNKGSLAQPLLSKLPEIFCCDDLAQTGTGVHCRYALRFLRRNGMATPHSKRGRTKLYRKEPPGDNRSPPPWQEPHGEGLAEKLSPGPAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>O83672</accession>
    <name>Y666_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0666</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0666</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71298">
        <property type="entry name" value="C71298"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882111.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83672"/>
    <dbReference type="IntAct" id="O83672">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0666"/>
    <dbReference type="EnsemblBacteria" id="AAC65642">
        <property type="protein sequence ID" value="AAC65642"/>
        <property type="gene ID" value="TP_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0666"/>
    <dbReference type="eggNOG" id="ENOG5031CXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2588682_0_0_12"/>
    <dbReference type="OMA" id="FLELMSA"/>
    <dbReference type="OrthoDB" id="2075048at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202298" description="Uncharacterized protein TP_0666">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <sequence length="97" mass="10661" checksum="3BEB212E2FFF16ED" modified="1998-11-01" version="1">MQKGSGASSVMTLYEYYLIFPDGECREISGPPCERSLLDMNGHPLRVPLSSNRVIAYRVAGKRTVAGGRGVVGIWYTLEQLDALELLEYVSGPLGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83694</accession>
    <name>O83694_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71293">
        <property type="entry name" value="E71293"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882141.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83694">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0696"/>
    <dbReference type="EnsemblBacteria" id="AAC65663">
        <property type="protein sequence ID" value="AAC65663"/>
        <property type="gene ID" value="TP_0696"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75874">
        <property type="protein sequence ID" value="AGN75874"/>
        <property type="gene ID" value="TPANIC_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0696"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.688"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067099_0_0_12"/>
    <dbReference type="OMA" id="IFHPIFW"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="278" mass="31187" checksum="2D310414C0FED928" modified="1998-11-01" version="1">MSRAFFLVDFQNDFCDPRGALFVPGADQDCVRVAEFLRVHAAHVDALYVSCDRHPRMHVAHPCFWRSLTGDALGPFDTVSFERLRSGACVPVRVGYVQTVAGYLAFRAYTGKGPLYLWPEHCVRGSWGQAVHPLIVEAVRFWQRAHRTRHPQFFFKGENPCVEQFSVLSSEYPASQGTADSLFVKRCQMLRAHERIFVAGEALSHCVVCTLQDMQRAGVLSRVSLLKDGSSVVPGFEQKTAASVQTLCAQGLTWLRMTEAAELLRTRFIFSGTEHQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83703</accession>
    <name>O83703_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TP_0705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71289">
        <property type="entry name" value="E71289"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882150.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83703"/>
    <dbReference type="STRING" id="243276.TPANIC_0705"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65673">
        <property type="protein sequence ID" value="AAC65673"/>
        <property type="gene ID" value="TP_0705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75880">
        <property type="protein sequence ID" value="AGN75880"/>
        <property type="gene ID" value="TPANIC_0705"/>
    </dbReference>
    <dbReference type="GeneID" id="57879230"/>
    <dbReference type="KEGG" id="tpa:TP_0705"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.695"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_12"/>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="55"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="411"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="811"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAC65673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="884" mass="98424" checksum="8B47090DBAC54C5B" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83705</accession>
    <name>Y707_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0707</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0707</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71289">
        <property type="entry name" value="G71289"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882152.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83705"/>
    <dbReference type="STRING" id="243276.TPANIC_0707"/>
    <dbReference type="EnsemblBacteria" id="AAC65694">
        <property type="protein sequence ID" value="AAC65694"/>
        <property type="gene ID" value="TP_0707"/>
    </dbReference>
    <dbReference type="GeneID" id="57879232"/>
    <dbReference type="KEGG" id="tpa:TP_0707"/>
    <dbReference type="HOGENOM" id="CLU_140399_0_0_12"/>
    <dbReference type="OMA" id="ADAQEPC"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202308" description="Uncharacterized protein TP_0707">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="159" mass="16909" checksum="DC363F323456F1CC" modified="1998-11-01" version="1">MRGTPAYHAVSGVPCSACTCTQVAVQLALSWRGSMGRLKRCEVRRRPCALWAIVRVARIGALAAMLAVLSFALGCALVYPLWALAVHRPRVFSVLSGLLYGGGAVLWGLRRVCNALSYARVRRAGRRAAAQEPCVLVQAGEVGAMGLSSSAEVRPAQEC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83714</accession>
    <name>FOLD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD</name>
        <name type="ordered locus">TP_0732</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71288">
        <property type="entry name" value="A71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882177.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83714"/>
    <dbReference type="SMR" id="O83714"/>
    <dbReference type="STRING" id="243276.TPANIC_0732"/>
    <dbReference type="EnsemblBacteria" id="AAC65701">
        <property type="protein sequence ID" value="AAC65701"/>
        <property type="gene ID" value="TP_0732"/>
    </dbReference>
    <dbReference type="GeneID" id="57879256"/>
    <dbReference type="KEGG" id="tpa:TP_0732"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_12"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000268552" description="Bifunctional protein FolD">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="315" mass="32819" checksum="4EFDE76DD5F3EA88" modified="1998-11-01" version="1">MDARLIDGKQAAHECTARLATRVQALRAAVGTAPFLAAVLVGDDPASCTYVAAKQRALARAHLRGETHRLPAHASHAQVLELIARLNEDARVHGILIQLPLPAHLDAARVCRAVAPEKDVDGFHPLNCGALFLAQPGFVPCTPAGIVHLLRRAQVPLAGARVVIVGRSAIVGRPLAVLLASPGCDATVTLCHSHTRGLADICVQADILVAALGKARFIGAPFVRTGAVVIDVGIHHVPDATAPRGRRLCGDVDFDAVAHKVQAITPVPGGVGPMTIAMLLHNTLCAAEYAAGMIPPFRAALYADLDGRAAGDVPH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83724</accession>
    <name>OBG_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">TP_0742</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71286">
        <property type="entry name" value="C71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882187.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83724"/>
    <dbReference type="SMR" id="O83724"/>
    <dbReference type="STRING" id="243276.TPANIC_0742"/>
    <dbReference type="EnsemblBacteria" id="AAC65711">
        <property type="protein sequence ID" value="AAC65711"/>
        <property type="gene ID" value="TP_0742"/>
    </dbReference>
    <dbReference type="GeneID" id="57879266"/>
    <dbReference type="KEGG" id="tpa:TP_0742"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_0_12"/>
    <dbReference type="OMA" id="VVFDWEP"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000386366" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="2">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="162"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <sequence length="376" mass="41145" checksum="F6F91264FB46578B" modified="1998-11-01" version="1">MASFVDEVLIRVSSGRGGNGCVAFRREKYVPRGGPAGGDGGRGGDVVFQVRRNMRTLVHLRYGRVFRAKNGQDGEGARRFGAKGHDCVIPLPPGCLLRDAQTHEVLHDFGHAHEGCVTLLSGGRGGWGNYHFRGPVQQAPQRAHSGQPGQERVVHVELRIVADVGFVGLPNAGKSSLLNFFTHARSRVAPYPFTTRIPYLGVLRTGDGRDVILADVPGILERASQGVGLGLRFLKHLTRCAGLAFLIDLADERALHTYDLLCKELYAFSPVFETKARVLVGTKLDLPNARECLQQLRAQHPSTEVCGVSVHNRWGLDELQEAFVRLSDAGAGALRSPVWRNQAPSFMYAQLEDPVCQVRDDFGATVSLSRKRKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83736</accession>
    <name>O83736_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, nitrogen regulatory IIA component (PtsN-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="F71284"/>
    </dbReference>
    <dbReference type="IntAct" id="O83736">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0755"/>
    <dbReference type="EnsemblBacteria" id="AAC65722">
        <property type="protein sequence ID" value="AAC65722"/>
        <property type="gene ID" value="TP_0755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75929">
        <property type="protein sequence ID" value="AGN75929"/>
        <property type="gene ID" value="TPANIC_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0755"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.743"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_5_0_12"/>
    <dbReference type="OMA" id="FDAPDEQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20428" checksum="6180502EAAC17259" modified="1998-11-01" version="1">MWRFRRSEVERWVDTCLSCSHRQSHSDVLPIERILSTDRILHLEQSERRPALYELSDCLSTAPQIKNRSELAAEIVRREELMSTAIGCGIAVPHVRLSSVTDLVMAVGISKKGIADFGPLDGQDVHLVFMIAAATNQHRYYLQTLSFFSSKLKRPDLRTRLLQTNTALEAYTVLTEQSSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83739</accession>
    <name>RS21_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsU</name>
        <name type="ordered locus">TP_0758</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71285">
        <property type="entry name" value="A71285"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882203.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83739"/>
    <dbReference type="SMR" id="O83739"/>
    <dbReference type="STRING" id="243276.TPANIC_0758"/>
    <dbReference type="EnsemblBacteria" id="AAC65725">
        <property type="protein sequence ID" value="AAC65725"/>
        <property type="gene ID" value="TP_0758"/>
    </dbReference>
    <dbReference type="GeneID" id="57879281"/>
    <dbReference type="KEGG" id="tpa:TP_0758"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_1_2_12"/>
    <dbReference type="OMA" id="FKRSCQK"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178397" description="30S ribosomal protein S21">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="69" mass="8406" checksum="979FADDA5864E322" modified="1998-11-01" version="1">MAHITVDDSENLEKAIKRFKRQVEKEGIIREWKKKEFYEKPSTLLNRKKKALRRKLMKKGRKVSDSRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83741</accession>
    <name>O83741_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein (Pbp-3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71285">
        <property type="entry name" value="C71285"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882205.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83741"/>
    <dbReference type="IntAct" id="O83741">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0760"/>
    <dbReference type="EnsemblBacteria" id="AAC65726">
        <property type="protein sequence ID" value="AAC65726"/>
        <property type="gene ID" value="TP_0760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75933">
        <property type="protein sequence ID" value="AGN75933"/>
        <property type="gene ID" value="TPANIC_0760"/>
    </dbReference>
    <dbReference type="GeneID" id="57879282"/>
    <dbReference type="KEGG" id="tpa:TP_0760"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.747"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_0_12"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="592"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="652" mass="71518" checksum="2BD943389A7F78AE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83745</accession>
    <name>O83745_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71285">
        <property type="entry name" value="G71285"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882209.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83745">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0764"/>
    <dbReference type="EnsemblBacteria" id="AAC65727">
        <property type="protein sequence ID" value="AAC65727"/>
        <property type="gene ID" value="TP_0764"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75937">
        <property type="protein sequence ID" value="AGN75937"/>
        <property type="gene ID" value="TPANIC_0764"/>
    </dbReference>
    <dbReference type="GeneID" id="57879286"/>
    <dbReference type="KEGG" id="tpa:TP_0764"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.751"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_12"/>
    <dbReference type="OMA" id="LYKNCKH"/>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="134"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="391" mass="43901" checksum="7A95EE5F35311FE2" modified="1998-11-01" version="1">MNTYAIVDIPEETHFSDDVYLDDTFLVLTPAGLFDEALKSRLQEWDFTTVHTGGQLLSSETTLECPLPASGDPNAKGAPGSEALRAQRSRFHALKKQYNEFQMFVEHVFDQYRAKQSLNTRAVIDRAKMLCELVKKHRQTLLRVLPTIPYREHYALETHALRSTLYAVVIGLQLKMQPFKIIELATSCLLHEIGMARVIPKAYTTEGELDPKTQKAIFAHPIISYHILRDHSLPLPVCVGALEHRERENGLGYPRRLVGEKISLYGKIIAVACSYEAATAPRSYKEMKNAAEGIVDLVRNANTQYDAVISRALLFALSFYPIGTHVHLSNGKIAQVVDVNPDDPRFPIVQVHGEIHRNGKPIIHSTSADEIFITRALSVKEQRLILQEGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83753</accession>
    <name>O83753_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mg2+ transport protein (MgtC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71281">
        <property type="entry name" value="G71281"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882219.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83753">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0774"/>
    <dbReference type="EnsemblBacteria" id="AAC65743">
        <property type="protein sequence ID" value="AAC65743"/>
        <property type="gene ID" value="TP_0774"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75947">
        <property type="protein sequence ID" value="AGN75947"/>
        <property type="gene ID" value="TPANIC_0774"/>
    </dbReference>
    <dbReference type="GeneID" id="57879296"/>
    <dbReference type="KEGG" id="tpa:TP_0774"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.761"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_12"/>
    <dbReference type="OMA" id="FMLIIMI"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="224" mass="24086" checksum="4B55F83DE6E1FE90" modified="1998-11-01" version="1">MITDSVIVVRLLLSFVSGLAIGLERSSKLQAAGLRTHTLICVGATGVMLLSLCVSEITGDHIGDPGRIAAQVVSGMGFLGGGAILKMGANVKGLTTATTIWVTAGIGLVIGAGLYSAGAMLVLLVLITLAGLDKIEKCVFPTRQNKRLEIQFSHHEPEVNEVMELLRKHSIIVISTNFQHSKSETSFPKLVLLISVPQKLNIRKLNHEVHMLECVQQFVLQETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83754</accession>
    <name>END3_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease III</fullName>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nth</name>
        <name type="ordered locus">TP_0775</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71281">
        <property type="entry name" value="H71281"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882220.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83754"/>
    <dbReference type="SMR" id="O83754"/>
    <dbReference type="STRING" id="243276.TPANIC_0775"/>
    <dbReference type="EnsemblBacteria" id="AAC65744">
        <property type="protein sequence ID" value="AAC65744"/>
        <property type="gene ID" value="TP_0775"/>
    </dbReference>
    <dbReference type="GeneID" id="57879297"/>
    <dbReference type="KEGG" id="tpa:TP_0775"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_0_12"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000102225" description="Endonuclease III">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HhH" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <sequence length="211" mass="23419" checksum="E6CA4C35DA370BAD" modified="1998-11-01" version="1">MRLLDSKGVHAVFEQLHAANPQPQGELHWRNTFTLLVAVLLSAQATDKSVNKATAALFDVADTPQAMLALGEERLCSYIRTINLYPTKARRIIALSAELIERFAAQVPCDAHALESLPGVGHKTANVVLNMGFGIPTIAVDTHILRTAPRIGLSSGRTPRAVERDLLVVTPREFRMHAHHWILLHGRYTCTARRPRCTECCLRDLCCKNNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83761</accession>
    <name>Y782_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0782</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0782</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71282">
        <property type="entry name" value="G71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882227.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83761"/>
    <dbReference type="SMR" id="O83761"/>
    <dbReference type="IntAct" id="O83761">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65752">
        <property type="protein sequence ID" value="AAC65752"/>
        <property type="gene ID" value="TP_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0782"/>
    <dbReference type="HOGENOM" id="CLU_1767241_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014260" description="Uncharacterized protein TP_0782">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="147" mass="15653" checksum="EDF61DB3B07DE574" modified="1998-11-01" version="1" precursor="true">MRTIFVGVLLLAIMGEGRLCALEWPVDKPKFLSLFGQSVGAGLLQQGLIFDGADSAGERGYAVRTAGYGRCVMRLQKHRRARVFPGALGNALIFAHEDGLQTVYANLREAKNAQDFGSTAEAESGVTVGYAGSSAWAPPNSFVFPGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83762</accession>
    <name>Y783_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0783</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0783</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65753.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71282">
        <property type="entry name" value="H71282"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882228.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0783"/>
    <dbReference type="EnsemblBacteria" id="AAC65753">
        <property type="protein sequence ID" value="AAC65753"/>
        <property type="gene ID" value="TP_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0783"/>
    <dbReference type="eggNOG" id="ENOG502ZG03">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056949_0_0_12"/>
    <dbReference type="OMA" id="TIIMEAP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202323" description="Uncharacterized protein TP_0783">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="377" mass="41681" checksum="AE223E42F70D1BFE" modified="2003-11-07" version="2">MKEIARHCTFSPMKIKEKKGYFISFSALFLIAYMFVAAVPLGADPYFLPIWARDLASELHXERPERAVRVNADTVQTLQPFMVGEYFGYFTDZGSVVFATRVTQRLSASTHAWAVYPEHAVRTPVFNPAGEHLAEIAEPGFVHIEADRFFLFSPGGNAVSSYDARGVQRWRVLHTAPITAFHSSAAGAVIGFSDGKVMVVRADGTVRCAFYPGGSTYEIVFGVTLSADGTLAACVCGLDRQRVILVSLADVQCKIVHHQYLEGALRHQLLMNFDTEGRYVVFEHAQGVGVIDCQRLETNIIPLVGDVVGMGVQPECDVVTVLSQKEQRCRFAVFERAVHRVGDVRFDAQDVSLTQGEKKFFLSIDMLLARIDIAGIP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>O83770</accession>
    <name>Y791_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0791</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0791</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71280">
        <property type="entry name" value="F71280"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83770"/>
    <dbReference type="IntAct" id="O83770">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0791"/>
    <dbReference type="EnsemblBacteria" id="AAC65765">
        <property type="protein sequence ID" value="AAC65765"/>
        <property type="gene ID" value="TP_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0791"/>
    <dbReference type="HOGENOM" id="CLU_2572858_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014262" description="Uncharacterized protein TP_0791">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="81" mass="8540" checksum="AF2DDCFDE552AEBF" modified="1998-11-01" version="1" precursor="true">MIDDHEALLLLVLSSGPAALASLPLHPVLGKGYRNTPGALEEKAVRISCVRECLNVVQIGGRIPVLLTSAAELPRLGSCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83784</accession>
    <name>O83784_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FemA protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71279">
        <property type="entry name" value="H71279"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882251.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83784">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0806"/>
    <dbReference type="EnsemblBacteria" id="AAC65773">
        <property type="protein sequence ID" value="AAC65773"/>
        <property type="gene ID" value="TP_0806"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75978">
        <property type="protein sequence ID" value="AGN75978"/>
        <property type="gene ID" value="TPANIC_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0806"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.792"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048411_0_0_12"/>
    <dbReference type="OMA" id="HRMGCWD"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="498" mass="56075" checksum="81710E41264431B8" modified="1998-11-01" version="1">MPPACVGVRDGCIARGRERIPLHTERTGSARQVMELFGRYLDPVHGEQYNGCPMFVVTVQKWTQETWTAETFLQSPAWAHFKRAYGWQTYVFSVHVRPDANTGGEKHFPLLILCKNIKPFGVFAYAPGAPPYLQDDQIPSRQMARARASLLRELTSALLPFFVRKPFLVRFDPPWGWAAAVCSLPSLASSSTHCAVGTEMELFTRELHACGLRRAACNVQPQDTLLLDMRPAREDIFAAFKPKWRYNVRRAQKHGVRVARFDTLAQEGSPGSLRAAVDVFYALYQKTAARDRIAIHTRQYYRDFCTAFAAQGMLVLCLAYAPRAALRVRIAGKDTPKNIETPHPPASEDRELGCADEQAIAALVLLCFDTCATYVYGASDYSARHLMAPYALQWYAIQEARARGCLWYDFYGIPPTDDVRHPMHGLYRFKTGFGGFVFHRVGSVDMPVRQLHAAAYACAERVRMGWFKRVRRMVCACLQSLGRQRTQNYSAHTAGAGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83789</accession>
    <name>Y813_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0813</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0813</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71278">
        <property type="entry name" value="B71278"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882257.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83789"/>
    <dbReference type="IntAct" id="O83789">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65785">
        <property type="protein sequence ID" value="AAC65785"/>
        <property type="gene ID" value="TP_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0813"/>
    <dbReference type="eggNOG" id="ENOG503391B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052664_0_0_12"/>
    <dbReference type="OMA" id="MMGTSEL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202332" description="Uncharacterized protein TP_0813">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <sequence length="428" mass="48023" checksum="CB6487DCAF145D78" modified="1998-11-01" version="1">MGAATTGFPIKAAVIHFTALSRHEQYIVSRALCALRTQPRRAQVVRRRVSNLKRLVRAMRSYSGADGADVERFGKGTVTDLADAGRFLFLPARVALRRGYLIAKIQTFAFLTQEVTRVALAEYLVQELRQVQFALVCMLMTEDLYLSLMEQEHVPARLKTAVTHALVALWEQRPDERARRATSALHQVWCAREHLAPSFGSMLGSSELFLLSTELDEMWRDFLVQRLSEAGVCTALEEFLFGISHEQIQAIRLQLRAQGVAALSRQEAYALIGEKGGGENTQAHAYQRVADLCSFYRSFIIRKRDAQARLRLNMPGPVRTIEEHYVEYLFFRQGKPVLYINVRAAPSTKSFPLGKVCRVETSGQHLLFFHTPSPEASPRAPAWKAGCAKSTLSEGAVFVRLLVLPIRRSALALACLRARVRAPRTDVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83792</accession>
    <name>Y816_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0816</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0816</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71278">
        <property type="entry name" value="E71278"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882260.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83792"/>
    <dbReference type="SMR" id="O83792"/>
    <dbReference type="IntAct" id="O83792">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0816"/>
    <dbReference type="EnsemblBacteria" id="AAC65787">
        <property type="protein sequence ID" value="AAC65787"/>
        <property type="gene ID" value="TP_0816"/>
    </dbReference>
    <dbReference type="GeneID" id="57879334"/>
    <dbReference type="KEGG" id="tpa:TP_0816"/>
    <dbReference type="eggNOG" id="ENOG5031CJJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299268_0_0_12"/>
    <dbReference type="OMA" id="TTEIEWN"/>
    <dbReference type="OrthoDB" id="1421451at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202333" description="Uncharacterized protein TP_0816">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <sequence length="221" mass="24379" checksum="EA88D4E73E15A690" modified="1998-11-01" version="1">MCFILPRMGAGVFVSDNRLQFSRSLAEVLRNQGCRVCLSAHEAARGDVPVRDGLVYWNRASPFSLRGILLQIENLGIVLETAVFVFDAQSYVDLYPGDDFSSIDRISVDLIVANMALVHMLTAHFVSQARGKLLFVHRETSAHCASAMVSVASAAFVRMAEECVLGLARKDAPRMQTLLIRLDGVDDDSYTQWIATQLASPVLSRGPGRWVRAGQRSFFGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83800</accession>
    <name>ACPS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">TP_0828</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71276">
        <property type="entry name" value="F71276"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882272.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83800"/>
    <dbReference type="SMR" id="O83800"/>
    <dbReference type="STRING" id="243276.TPANIC_0828"/>
    <dbReference type="EnsemblBacteria" id="AAC65794">
        <property type="protein sequence ID" value="AAC65794"/>
        <property type="gene ID" value="TP_0828"/>
    </dbReference>
    <dbReference type="GeneID" id="57879345"/>
    <dbReference type="KEGG" id="tpa:TP_0828"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_3_1_12"/>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175724" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="125" mass="14118" checksum="88A05B5B0D20821F" modified="1998-11-01" version="1">MIIGVGIDIVEIERFVSWTHNVRLLRRFFHQEEIVDFFKNHMRAQFLATRFAAKEAFGKALGTGLRNMELRNIRVCQNGWGKPRLEVYGAAQAMLAATGGTHIQVSLTHEREVASAIVIIEGEPL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83808</accession>
    <name>Y836_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0836</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0836</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71275">
        <property type="entry name" value="A71275"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882280.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83808"/>
    <dbReference type="IntAct" id="O83808">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0836"/>
    <dbReference type="EnsemblBacteria" id="AAC65808">
        <property type="protein sequence ID" value="AAC65808"/>
        <property type="gene ID" value="TP_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0836"/>
    <dbReference type="eggNOG" id="ENOG5033874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119764_0_0_12"/>
    <dbReference type="OMA" id="WIIGYSE"/>
    <dbReference type="OrthoDB" id="1381586at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202336" description="Uncharacterized protein TP_0836">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <sequence length="274" mass="31036" checksum="CD6C30C3DA646121" modified="1998-11-01" version="1">MTRSQWHALAAFRTDLKAFCVQSLRAFGYPYMDPHAAQSAVACCTPQAFLHRAQAALVRAQGIPTYPVHTPIVYPHALEELTQSDPVPALILVSDNPGKEEQLHTQQRYLVGQSGRVAQGFFSRHAQLGVDFRTDVMLLNKTPLHTAKTVQLRALVRLLAQDPAGTARARQVQSFLHRSQCWMARRTCQLQRSLGCDLWIVGYSELKSGHLFEPYARLLQTVCDRRTPLFVFQHFSMNCFARDFAKARARSPQQQVCDTLKDLGLHHRQQILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>O83810</accession>
    <name>O83810_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71275">
        <property type="entry name" value="C71275"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0838"/>
    <dbReference type="EnsemblBacteria" id="AAC65805">
        <property type="protein sequence ID" value="AAC65805"/>
        <property type="gene ID" value="TP_0838"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76008">
        <property type="protein sequence ID" value="AGN76008"/>
        <property type="gene ID" value="TPANIC_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0838"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.825"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_12"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="554" mass="62676" checksum="4A4CB62943D52230" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>O83823</accession>
    <name>Y851_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0851</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0851</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71274">
        <property type="entry name" value="C71274"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882295.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83823"/>
    <dbReference type="SMR" id="O83823"/>
    <dbReference type="IntAct" id="O83823">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0851"/>
    <dbReference type="EnsemblBacteria" id="AAC65821">
        <property type="protein sequence ID" value="AAC65821"/>
        <property type="gene ID" value="TP_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0851"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382600_0_0_12"/>
    <dbReference type="OMA" id="GFWPGLC"/>
    <dbReference type="OrthoDB" id="194120at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032533">
        <property type="entry name" value="DUF4954"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16314">
        <property type="entry name" value="DUF4954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202339" description="Uncharacterized protein TP_0851">
        <location>
            <begin position="1"/>
            <end position="724"/>
        </location>
    </feature>
    <sequence length="724" mass="81941" checksum="7BE5FB5485B5FD5B" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>O83839</accession>
    <name>Y869_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0869</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0869</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71270">
        <property type="entry name" value="C71270"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882312.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83839"/>
    <dbReference type="IntAct" id="O83839">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0869"/>
    <dbReference type="EnsemblBacteria" id="AAC65845">
        <property type="protein sequence ID" value="AAC65845"/>
        <property type="gene ID" value="TP_0869"/>
    </dbReference>
    <dbReference type="GeneID" id="57879384"/>
    <dbReference type="KEGG" id="tpa:TP_0869"/>
    <dbReference type="HOGENOM" id="CLU_197660_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202342" description="Uncharacterized protein TP_0869">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <sequence length="78" mass="8735" checksum="E5F53FBDAE1B5A82" modified="1998-11-01" version="1">MRSCPKRARGVHWATGAALWCPSRMIFEKISPLQAFVWAVLRLFLKSFRTVFRGAVRAGCGVLACVRAYGFPPYGSKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>O83845</accession>
    <name>TSAE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tsaE</name>
        <name type="ordered locus">TP_0875</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71271">
        <property type="entry name" value="A71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882318.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83845"/>
    <dbReference type="SMR" id="O83845"/>
    <dbReference type="IntAct" id="O83845">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0875"/>
    <dbReference type="EnsemblBacteria" id="AAC65838">
        <property type="protein sequence ID" value="AAC65838"/>
        <property type="gene ID" value="TP_0875"/>
    </dbReference>
    <dbReference type="GeneID" id="57879389"/>
    <dbReference type="KEGG" id="tpa:TP_0875"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_5_2_12"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000096220" description="tRNA threonylcarbamoyladenosine biosynthesis protein TsaE">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="35"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="135" mass="14672" checksum="F34B162FF294ACCC" modified="1998-11-01" version="1">MRCVSRSAQDTARWGTVVGRLLEEGSVVVLQGALAAGKTCFVKGLALGLGIQEEITSPTFTLLAVYHGRLTLYHMDVYRLASLEDFFDIGAQECVYGTGVCVIEWGERVASELPEYTVTISLRVLADGNREITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83852</accession>
    <name>O83852_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71268">
        <property type="entry name" value="G71268"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882325.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0882"/>
    <dbReference type="EnsemblBacteria" id="AAC26572">
        <property type="protein sequence ID" value="AAC26572"/>
        <property type="gene ID" value="TP_0882"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76051">
        <property type="protein sequence ID" value="AGN76051"/>
        <property type="gene ID" value="TPANIC_0882"/>
    </dbReference>
    <dbReference type="GeneID" id="57879396"/>
    <dbReference type="KEGG" id="tpa:TP_0882"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.866"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035419_0_0_12"/>
    <dbReference type="OMA" id="ESNRYPN"/>
    <dbReference type="OrthoDB" id="429052at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC26572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="500" mass="55969" checksum="2678CC21503335BA" modified="1998-11-01" version="1">MHLRSDSPSVFKIERYRMERRGNGVKGSSLFVHYCSVHVAILFLGRGVPMFAKETGTQHVQEQERHIDITDEKTVLLKKRMNTIKYGLVSDIISLIEELKKENNASLNETLCMLCGRTKSSELKALLFDFFLFQKNDCAQSVAVDVLQQVTEHNPMVVKSAIRYISGLEARELTPLLREVLSSEVSQYADECIVALGNMGSTEDSEFLVRYYENIHFDDDKKTLIRKQNVMAALEQLHAEHAFDFFKLVVMSSEENSVVRASAAVGLAGIGRSDAVEILSVLSEESDPILRIASIKGAGLLDTDEARNIVIEGFRDTHYRARLEALAVAERVLCASYFPYVLYRAQSDPVDAVLHKAVDLVAKYNLGEGNDWLRDVLLDEKKSDTLRARVAAAGMQYTISALYQHIEKVMLDVVLNDTKKQLRYALGKAFAKTRTELGQTIAAAYLASKDVLTVGIGLDMYQTNQYSALSEHIEKIAGDNKFGALQAKARQILARQKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83854</accession>
    <name>O83854_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71269">
        <property type="entry name" value="A71269"/>
    </dbReference>
    <dbReference type="IntAct" id="O83854">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0884"/>
    <dbReference type="EnsemblBacteria" id="AAC26574">
        <property type="protein sequence ID" value="AAC26574"/>
        <property type="gene ID" value="TP_0884"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76053">
        <property type="protein sequence ID" value="AGN76053"/>
        <property type="gene ID" value="TPANIC_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0884"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.868"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_0_12"/>
    <dbReference type="OMA" id="PYSSKQY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="362" mass="40352" checksum="678188A0D33B58E8" modified="1998-11-01" version="1">MYVCEVVFKHILVGVLCFFLVFFVNNVLLFAQTLLTKHVSAADVVRLLLYSIPAALIYVTPFAVLVGSLLGLGRLRNNLELLALQVLGVSPRFLIFPLLSIGLCSALFVFVFSDVVVPASFIRLRQVYWRVLSSVPSLGFESHTTRKHNGVILSVGEVFHSVMYQLLIVDKSDSRSLKVVSSRKSVLESSADQTVPFTIRMHDPCMLIVYRTRPRICDLIYGGRADYHVHTQQTQPEYFMGLGPGGFSTCSLYREIQEKIKAKENPRHIATYQLEFQKKFSHPISVVLFIFLSFGLSTLSNISSQGKGFVGGLIVVLGYWIISIGGQELALRLSIVPSLALWIPNAALFFTALILSMRKSAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>O83863</accession>
    <name>RIMP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">TP_0893</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71266">
        <property type="entry name" value="B71266"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882336.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83863"/>
    <dbReference type="SMR" id="O83863"/>
    <dbReference type="IntAct" id="O83863">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0893"/>
    <dbReference type="EnsemblBacteria" id="AAC65850">
        <property type="protein sequence ID" value="AAC65850"/>
        <property type="gene ID" value="TP_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0893"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_4_0_12"/>
    <dbReference type="OMA" id="AAEFPIF"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000181948" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="156" mass="16707" checksum="476303CA53AF2565" modified="1998-11-01" version="1">MNFSPNTLGSFESCAEVVRSLGCALVDLQWSVSAVSRRVQQAQGRARAVIYSAGGVTLDVCARVHRILVPRLQALGGVRTVFLEVGSPGERVIRNAAEFSIFLGETVKVWFCTGQFQVGTLAFADETCLTLTAGGVPVTIPYVQLTKAQLHPAVRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83908</accession>
    <name>Y938_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0938</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0938</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71262">
        <property type="entry name" value="F71262"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882381.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83908"/>
    <dbReference type="IntAct" id="O83908">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0938"/>
    <dbReference type="EnsemblBacteria" id="AAC65898">
        <property type="protein sequence ID" value="AAC65898"/>
        <property type="gene ID" value="TP_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0938"/>
    <dbReference type="eggNOG" id="ENOG50302BP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175015_0_0_12"/>
    <dbReference type="OMA" id="ISDNEVM"/>
    <dbReference type="OrthoDB" id="1148574at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014266" description="Uncharacterized lipoprotein TP_0938">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <sequence length="276" mass="30824" checksum="E1EBBA150B3FD7D8" modified="1998-11-01" version="1" precursor="true">MKFCRGWRGARAGQFARLLCVCWCSLGACSCVRESTERSGVVPISPSSQQKVLFVFGKKYSGHVYLVDCVERVCEAWRMRARVVEYGDLTRLSALPRMKVVLEAVHEMRPDAVVSLGLPVGGGKYLLAVKRERAQTLIVSLLPEEEVLPMQAGSDILVDFQVKEDSLEGVAEVSNTEAELQSLLRAACEIVRRRGVARRAHASPLQEFRGAFANVTDSLREQGVFSSDYAMECYVDPETGVRAYNHVLLSKRVETFRFVRSYGGSPGRSVHERDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>O83920</accession>
    <name>O83920_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71261">
        <property type="entry name" value="H71261"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882398.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83920"/>
    <dbReference type="IntAct" id="O83920">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0954"/>
    <dbReference type="EnsemblBacteria" id="AAC65909">
        <property type="protein sequence ID" value="AAC65909"/>
        <property type="gene ID" value="TP_0954"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76119">
        <property type="protein sequence ID" value="AGN76119"/>
        <property type="gene ID" value="TPANIC_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0954"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.938"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039050_0_0_12"/>
    <dbReference type="OMA" id="RMASWEM"/>
    <dbReference type="OrthoDB" id="995207at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010503430" evidence="2">
        <location>
            <begin position="25"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="478" mass="54661" checksum="560DC32655A6EA1D" modified="1998-11-01" version="1">MRYGTLFKVSVLLGALFVSCVSTGSNSARESERAQLLKSENPNIRFAAQLSGLLEKQRWEEALQLFDTLSPEHRAEKRIQYLYLSTLISAGKLTHAQELAEKLGQDGPTASETVQLWYAHAMIAQAKRDVRKKKQYVEKILAQDPHDLWALTERGYDFLSVNDYAQAVQAFSRALRVEPRAQDARVGLGKVYYLQGKMQEAEAQYRQVLQDTPEHERALAECARVKAETNRVLEAIRDLERVVQLDPHDPAYWTDLGTYLSQAGKKERAAAAFERAVALSADAYFAHIYLGGIYDELGRAEKAIEHYQRAVQLYPKYHFSFESLGVLFWEQQRWEEAREAFATALTYAPTNISYALMTALCLCQMGQAHKAQHFMRTFIRTVDRTRREVEYFLCRLFVDLSGEQDMASRISKIKSVPQRIRYSFYLAFFYELGGRHLLAEKHYGEVESARAPSSFEHRLAVSALGRLRGRSSSLRTNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83921</accession>
    <name>Y955_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0955</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0955</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71262">
        <property type="entry name" value="A71262"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83921"/>
    <dbReference type="IntAct" id="O83921">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0955"/>
    <dbReference type="EnsemblBacteria" id="AAC65911">
        <property type="protein sequence ID" value="AAC65911"/>
        <property type="gene ID" value="TP_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0955"/>
    <dbReference type="HOGENOM" id="CLU_2439902_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202362" description="Uncharacterized protein TP_0955">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <sequence length="90" mass="10661" checksum="ABB990630CA8932C" modified="1998-11-01" version="1">MTGVPTPILIIPIHEIKSFQNRLDIRDAARWIALATVLERAQFFLKNFTIFELFPGLPARHRRKHKLIFPLRSRAWLLWGSSRKVPLRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83926</accession>
    <name>O83926_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71259">
        <property type="entry name" value="C71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882404.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83926">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0960"/>
    <dbReference type="EnsemblBacteria" id="AAC65915">
        <property type="protein sequence ID" value="AAC65915"/>
        <property type="gene ID" value="TP_0960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76125">
        <property type="protein sequence ID" value="AGN76125"/>
        <property type="gene ID" value="TPANIC_0960"/>
    </dbReference>
    <dbReference type="GeneID" id="57879470"/>
    <dbReference type="KEGG" id="tpa:TP_0960"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.944"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_12"/>
    <dbReference type="OMA" id="TRDGTFH"/>
    <dbReference type="OrthoDB" id="1488472at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="184"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="264" mass="28597" checksum="B75B48928F04F337" modified="1998-11-01" version="1">MVRSLWTAATGMNGQQANIDTVANNLANVNTSGFKRQRAEFEDLLYQTIRTAGTPATEDTLTPVGVRMGHGVKLAATQRLFEQGSLQHTGVSGDVAIAGEGFFRVLQYDGTYAYTRDGSFKVDAERQLVTSNGLRLVPEIIFPENYVEHSIAISKDGRVTVRVGEQGDPVEVGQLELYRFANNAGLAAEGGNVFTQTPASGQPIPGRPGFEGFGKVEHKFLEMSNVSTVSEMVNMIVAQRAYEFNSKAIQTSDNMLGTAVALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83937</accession>
    <name>O83937_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71257">
        <property type="entry name" value="B71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882416.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83937">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0972"/>
    <dbReference type="TCDB" id="2.A.108.2.11">
        <property type="family name" value="the iron/lead transporter (ilt) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65929">
        <property type="protein sequence ID" value="AAC65929"/>
        <property type="gene ID" value="TP_0972"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76136">
        <property type="protein sequence ID" value="AGN76136"/>
        <property type="gene ID" value="TPANIC_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0972"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.957"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023979_2_0_12"/>
    <dbReference type="OMA" id="RWQAFIR"/>
    <dbReference type="OrthoDB" id="433945at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="448" mass="48456" checksum="8F71B4BC6CF3E00B" modified="1998-11-01" version="1">MERSWEGIDRGVPVYGMGCTMVAPGMPAAFARSVVRASAWVGVALMCVAWSVSAAEGTRSGGQAQERLSSWRQVVQRMEVHLRAAYTFFESGDSDRAYEQIDKAYFRYYEAKGMEKITMGYLSGARKAAVENAFFAYRRSVRGARDLAGVAFCRDKLVTMLYEDARALDGVARGRAGFAAHIATFVASCVLVLREGIEAILVIAAIVAYLVKTGKERCCAAVYAGAGAGVLFSVVLAVMIVRVLGSEGGAAQEIIEGVGMFFAAAMLFYVSNWMLSKARACAWDRYIRQKVERSVSRGNQWALVATAFLAVAREGAELILFFRGIPVAGPYGRLAVWAAVTVSALVLVGVFVAIRFLSVRLPLRPFFVATGAVMYLLCFSFVGKGVSELQEAGVVSRSTAPWMHGWSFDFLGIYPTYEGLAPQAFVVALVVLSAVWWCGGLCRGASST</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83972</accession>
    <name>RIR1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Ribonucleoside-diphosphate reductase subunit alpha</fullName>
            <ecNumber>1.17.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ribonucleotide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nrdA</name>
        <name type="ordered locus">TP_1008</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction.</text>
    </comment>
    <comment type="pathway">
        <text>Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71255">
        <property type="entry name" value="B71255"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882452.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83972"/>
    <dbReference type="SMR" id="O83972"/>
    <dbReference type="IntAct" id="O83972">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1008"/>
    <dbReference type="PRIDE" id="O83972"/>
    <dbReference type="EnsemblBacteria" id="AAC65956">
        <property type="protein sequence ID" value="AAC65956"/>
        <property type="gene ID" value="TP_1008"/>
    </dbReference>
    <dbReference type="GeneID" id="57879519"/>
    <dbReference type="KEGG" id="tpa:TP_1008"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_3_0_12"/>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187223" description="Ribonucleoside-diphosphate reductase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine radical intermediate" evidence="1">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="534"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="725"/>
            <end position="729"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for hydrogen atom transfer" evidence="1">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="site" description="Allosteric effector binding" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="site" description="Allosteric effector binding" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="site" description="Important for hydrogen atom transfer" evidence="1">
        <location>
            <position position="574"/>
        </location>
    </feature>
    <feature type="site" description="Important for electron transfer" evidence="1">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <feature type="site" description="Important for electron transfer" evidence="1">
        <location>
            <position position="829"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with thioredoxin/glutaredoxin" evidence="1">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with thioredoxin/glutaredoxin" evidence="1">
        <location>
            <position position="843"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="319"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="845" mass="95987" checksum="47DC688E4D0B356C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-04-27" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83981</accession>
    <name>RNY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Y</fullName>
            <shortName evidence="1">RNase Y</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rny</name>
        <name type="ordered locus">TP_1018</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71253">
        <property type="entry name" value="F71253"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882462.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83981"/>
    <dbReference type="IntAct" id="O83981">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1018"/>
    <dbReference type="EnsemblBacteria" id="AAC65967">
        <property type="protein sequence ID" value="AAC65967"/>
        <property type="gene ID" value="TP_1018"/>
    </dbReference>
    <dbReference type="GeneID" id="57879530"/>
    <dbReference type="KEGG" id="tpa:TP_1018"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_12"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000163805" description="Ribonuclease Y">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="194"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="320"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="504" mass="57071" checksum="D61EEE69B6434745" modified="1998-11-01" version="1">MTTSIVIGVVLVTVGLTFGWTIRWLYARFHLSACEQRAERILQEAQKEAESKKKSILLEAKEYVLRERNQQERDDRDRRAELQRAERRLLQKEEALSTRAGELDSRERSLKQRDQSLCQEEARYRQELERVSGLTQNQARDLIIKNLENEAKHDAQALINKIEEDAALNAERRARDILVTTMQRITADVTGDVTVSTVNLPSEEMKGRIIGREGRNIRALETLTGADVVVDDTPEAVVISCFDPVRKEIARISLERLVLDGRIHPARIEEIVQKVTQEVSQKIYEEGEKVLFDLGIHDMCPEGVRALGRLYFRTSYGQNVLYHSKEVALLASMLASEIGADVAIAKRGALLHDIGKGVETDSDRNHAEIGMEMARKMNEDPRVVNAVGSHHNDIEPCCVESWLVQVADAISAARPGARREMVDHYVKRLENLEAIAEGFSGVEKAYAIQAGRELRVLVNNDKIPDRDVKALGRDIAKKIESDLKYPGRIRVTLIRETRVVEYAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83988</accession>
    <name>RL13_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">TP_1025</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71251">
        <property type="entry name" value="D71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882469.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83988"/>
    <dbReference type="SMR" id="O83988"/>
    <dbReference type="STRING" id="243276.TPANIC_1025"/>
    <dbReference type="EnsemblBacteria" id="AAC65975">
        <property type="protein sequence ID" value="AAC65975"/>
        <property type="gene ID" value="TP_1025"/>
    </dbReference>
    <dbReference type="GeneID" id="57879537"/>
    <dbReference type="KEGG" id="tpa:TP_1025"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_12"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000133755" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="142" mass="15770" checksum="3B930B6BBE57EE40" modified="1998-11-01" version="1">MRTIFVNEREAVRAWHLIDAAGRPLGRVAARVACLLRGKHKASYTPNQEMGDYVVVINAEKVFLSGTKPKDKMYYRHSGYPGGLKSVSFSALVKRRPVEPLRHAVKGMLPKGPLGRKLIKNVKIYAGSVHPHESQNPVPLSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>O83995</accession>
    <name>Y1032_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_1032</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_1032</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71252">
        <property type="entry name" value="C71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882476.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83995"/>
    <dbReference type="SMR" id="O83995"/>
    <dbReference type="IntAct" id="O83995">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1032"/>
    <dbReference type="EnsemblBacteria" id="AAC65984">
        <property type="protein sequence ID" value="AAC65984"/>
        <property type="gene ID" value="TP_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="57879543"/>
    <dbReference type="KEGG" id="tpa:TP_1032"/>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1795627_0_0_12"/>
    <dbReference type="OMA" id="QYCVRQG"/>
    <dbReference type="OrthoDB" id="1864717at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202376" description="Uncharacterized protein TP_1032">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="144" mass="15442" checksum="7B72748E32A57884" modified="1998-11-01" version="1">MACGENERASTSPPNRAAAARGGRLTLLDGCCVALVLALTAWSGFFVYRMQGGARTLDIRCGAQRWTYPLDQERVIRVRGPLGETEIEIRAGAARVCRSPCANGTCIAHPPVQRVGEWNACLPNGVFLYVHGTDAAEPEADAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O88098</accession>
    <name>O88098_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formate hydrogenlyase transcriptional activator (FhlA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71370">
        <property type="entry name" value="A71370"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0082"/>
    <dbReference type="EnsemblBacteria" id="AAC65077">
        <property type="protein sequence ID" value="AAC65077"/>
        <property type="gene ID" value="TP_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0082"/>
    <dbReference type="eggNOG" id="COG3604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_125_2_12"/>
    <dbReference type="OMA" id="RAGRFQM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="258"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="600" mass="66418" checksum="1BA57B4915195A1D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1991-08-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>P21991</accession>
    <name>FLAB2_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin FlaB2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Flagellar filament 33 kDa core protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">flaB2</name>
        <name type="ordered locus">TP_0792</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1989" name="Infect. Immun." volume="57" first="2166" last="2172">
            <title>Cloning and sequencing of a Treponema pallidum gene encoding a 31.3-kilodalton endoflagellar subunit (FlaB2).</title>
            <authorList>
                <person name="Pallesen L."/>
                <person name="Hindersson P."/>
            </authorList>
            <dbReference type="PubMed" id="2659537"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1988" name="J. Bacteriol." volume="170" first="4072" last="4082">
            <title>Antigenic relatedness and N-terminal sequence homology define two classes of periplasmic flagellar proteins of Treponema pallidum subsp. pallidum and Treponema phagedenis.</title>
            <authorList>
                <person name="Norris S.J."/>
                <person name="Charon N.W."/>
                <person name="Cook R.G."/>
                <person name="Fuentes M.D."/>
                <person name="Limberger R.J."/>
            </authorList>
            <dbReference type="PubMed" id="3045083"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 1-21</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1988" name="Infect. Immun." volume="56" first="168" last="175">
            <title>Antigenic and structural characterization of Treponema pallidum (Nichols strain) endoflagella.</title>
            <authorList>
                <person name="Blanco D.R."/>
                <person name="Champion C.I."/>
                <person name="Miller J.N."/>
                <person name="Lovett M.A."/>
            </authorList>
            <dbReference type="PubMed" id="2447018"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 1-20</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2006" name="J. Bacteriol." volume="188" first="7700" last="7706">
            <title>Novel conserved assembly factor of the bacterial flagellum.</title>
            <authorList>
                <person name="Titz B."/>
                <person name="Rajagopala S.V."/>
                <person name="Ester C."/>
                <person name="Haeuser R."/>
                <person name="Uetz P."/>
            </authorList>
            <dbReference type="PubMed" id="16936039"/>
            <dbReference type="DOI" id="10.1128/JB.00820-06"/>
        </citation>
        <scope>INTERACTION WITH FLIW</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Component of the core of the flagella.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides. Interacts with FliW; a synthetic peptide of FlaB1 (residues 229-247) partially blocks binding of this protein to FliW (PubMed:16936039).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Periplasmic flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A37053">
        <property type="entry name" value="A37053"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882237.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P21991"/>
    <dbReference type="SMR" id="P21991"/>
    <dbReference type="IntAct" id="P21991">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0792"/>
    <dbReference type="PRIDE" id="P21991"/>
    <dbReference type="EnsemblBacteria" id="AAC65757">
        <property type="protein sequence ID" value="AAC65757"/>
        <property type="gene ID" value="TP_0792"/>
    </dbReference>
    <dbReference type="GeneID" id="57879313"/>
    <dbReference type="KEGG" id="tpa:TP_0792"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_2_0_12"/>
    <dbReference type="OMA" id="FEHTINN"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182635" description="Flagellin FlaB2">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16936039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="2">
        <source>
            <dbReference type="PubMed" id="2659537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="286" mass="31347" checksum="650BA1B2260DEDB2" modified="1998-12-15" version="2">MIINHNMSAMFSQRTLGHTNLSVQKNIEKLSSGLRINRSGDDASGLAVSEKMRSQIRGLNQASTNAQNGISFIQVAEAFLQETTDVIQRIRELSVQAANGIYSAEDRLYIQVEVSQLVAEVDRIASHAQFNGMNMLTGRFARQGGENTVTASMWFHIGANMDQRTRAYIGTMTAVAMGIRDAGDESVMNIDSPEKANRAIGTLDQAIKRINKQRADLGAYQNRLDHTVAGINVAAENLQAAESRIRDVDMAKEMVDYTKNQILVQSGTAMLAQANQATQSVLSLLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>P74936</accession>
    <name>PROB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">TP_0351</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="8" first="63" last="70">
            <title>Nucleotide sequences of the proA and proB genes of Treponema pallidum, the syphilis agent.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
            <dbReference type="PubMed" id="9522123"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="U61535">
        <property type="protein sequence ID" value="AAB39981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71336">
        <property type="entry name" value="F71336"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881799.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74936"/>
    <dbReference type="SMR" id="P74936"/>
    <dbReference type="IntAct" id="P74936">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0351"/>
    <dbReference type="EnsemblBacteria" id="AAC65336">
        <property type="protein sequence ID" value="AAC65336"/>
        <property type="gene ID" value="TP_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0351"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_0_2_12"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000109750" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="296" mass="31315" checksum="4276927F287E4F14" modified="1997-02-01" version="1">MIRALFAAAKKIVIKIGSNTLAQADGTPDEEFLAECARACAALMRDGKQIVVVSSGAQVAGISALHCLSSPPQGAGLERHESRGVIPGDGASCKQALCAVGQAELISRWRSAFAAHQQCVGQFLCTKEDFTDSDRAAQVRYTLSFLLERRVVPILNENDALCCSDVPSVPADRRVSLSPQKRIGDNDSLSAFVALLWQADLLLLLSDIDGVYDKDPKAHTDAQHVPLVTDVSALVGKTSMGSSNVFGTGGIATKLDAARLVTRAGIPLVLANGRHLDPILSLMRGDARGTLFVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7IU72</accession>
    <name>F7IU72_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine-binding chemotaxis protein (CheW-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71335">
        <property type="entry name" value="B71335"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881812.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0364"/>
    <dbReference type="EnsemblBacteria" id="AAC65349">
        <property type="protein sequence ID" value="AAC65349"/>
        <property type="gene ID" value="TP_0364"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75561">
        <property type="protein sequence ID" value="AGN75561"/>
        <property type="gene ID" value="TPANIC_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0364"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.363"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597086_0_0_12"/>
    <dbReference type="OMA" id="LVDIMQV"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="246"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="455" mass="50047" checksum="3ECD9FF49C43195D" modified="2011-07-27" version="1">MVGDLGHGLGTMIEHMEAEIGIRESFDGGVREPLAVIDFKMVTFSLAGKDYAVDIMQVKEIAKAGSFTYVPNTSPFVLGVYNLRGDIIPIIDLRRFFNIPAPRKSRQAIENMVIVTVEDQTFGVVVDGIDKVIGVSKTTIQPPHPIFGDINIKYIRGVVEEAGKLYILLDVHRIFSFRLGEEERTAVVDRGVVPSPSPPAVSVPPGDEENLNVGFISDTLAAFGRFFTSAVNEGWLRSRYLVWRDVRSGAEVQLQHEEDVAEFLSTFPSPDTGVFWSGEYAASVGSVLSRMQVGKVVTVWNIGCGAGHESYSLAVLLRKTFPDAVVRVHASDSDLFSISNAPMLTVPEHVIGDWYKPYVVKGVSGSYTFSQEIKEMVLFEYHDCTHPSALPDVDLIVARDVLSSLAVPVQHTLLKEFSEKLKATGVVLLGQNEVMPKDTGWLRQIEGTVAVFSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7IV43</accession>
    <name>F7IV43_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl-diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71295">
        <property type="entry name" value="C71295"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882128.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0683"/>
    <dbReference type="EnsemblBacteria" id="AAC65646">
        <property type="protein sequence ID" value="AAC65646"/>
        <property type="gene ID" value="TP_0683"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75861">
        <property type="protein sequence ID" value="AGN75861"/>
        <property type="gene ID" value="TPANIC_0683"/>
    </dbReference>
    <dbReference type="GeneID" id="57879208"/>
    <dbReference type="KEGG" id="tpa:TP_0683"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.675"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_12"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="364" mass="40170" checksum="EB3588FB570D6A69" modified="2011-07-27" version="1">MKRALAQRLRNIERALADALPAQPTRSWMGTRLRVLASEDTRVLRTVCNACVSCGGKRWRPLLLILSAELAHACVQCTHRKLQGHKRKKISEREWYTLSAVVELIHTASLLHDDIEDHSSTRRGKPCAYLRYGTDCVLNAASWLYFHAHALIDTLSIEPALKAALFSATISATRALHMGQALDIAWHRSPELIPSRAQYLRMVALKTGALIALSGELGFLCAGYSAREARSFGAQVMPIGIGFQILDDVQGIDGGVSGKAHADDIVEGKKSFPVILHVHTHPQDAPTFARLFAAARAEGLHSPAVKQAQRILYSSEALTHARAYGLRMIERTLTRVHAHFPCNPACQLWCTAVQYGVRAHLHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7IWA5</accession>
    <name>F7IWA5_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein J (TprJ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71301">
        <property type="entry name" value="F71301"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882067.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0621"/>
    <dbReference type="EnsemblBacteria" id="AAC65595">
        <property type="protein sequence ID" value="AAC65595"/>
        <property type="gene ID" value="TP_0621"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75802">
        <property type="protein sequence ID" value="AGN75802"/>
        <property type="gene ID" value="TPANIC_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0621"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.613"/>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="96"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="555"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="758" mass="81369" checksum="FFF93A8951E261B8" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83057</accession>
    <name>Y013_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0013</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0013</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71377">
        <property type="entry name" value="B71377"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881462.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83057"/>
    <dbReference type="SMR" id="O83057"/>
    <dbReference type="IntAct" id="O83057">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0013"/>
    <dbReference type="PRIDE" id="O83057"/>
    <dbReference type="EnsemblBacteria" id="AAC65013">
        <property type="protein sequence ID" value="AAC65013"/>
        <property type="gene ID" value="TP_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0013"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114543_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024258">
        <property type="entry name" value="DUF3798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12683">
        <property type="entry name" value="DUF3798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202175" description="Uncharacterized protein TP_0013">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <sequence length="221" mass="23872" checksum="5E1B311377B49DB2" modified="1998-11-01" version="1">MKSQFLLKVWVVCVGALLCRCGGARAPQNTGGTKAVEDYHIGVMTGPGSHSSHDVVAAKRACAMYGAVGDGHRGCILHVTYPEDFVNRQDETVSRLLAFADDPLMGAIVVSEGIHGTAEAFNKIRAKRSDIMLFVGDPHEYPELIQKSADIVVSDDYAFGGYAIPWAAKKMGARTLVHVSFPRHLSKAELRTRRQVMEAVCADIGIEFASEEAPDPAGVRC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>O83058</accession>
    <name>Y014_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0014</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0014</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71377">
        <property type="entry name" value="C71377"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881463.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83058"/>
    <dbReference type="SMR" id="O83058"/>
    <dbReference type="IntAct" id="O83058">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65014">
        <property type="protein sequence ID" value="AAC65014"/>
        <property type="gene ID" value="TP_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0014"/>
    <dbReference type="HOGENOM" id="CLU_1523020_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024258">
        <property type="entry name" value="DUF3798"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12683">
        <property type="entry name" value="DUF3798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202176" description="Uncharacterized protein TP_0014">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <sequence length="202" mass="22940" checksum="31634655A577A5FF" modified="1998-11-01" version="1">MRLRRLQIPQESGVEGARAFIGTHTKQWIGKYGKNTMFFCTNDTHRVSLMRELVSKDGMLLGANVFDCAEALGVEYADDEDVSGILERVESAVEEKRLVGRFGVNVSSHIFVSTLGLTEYARRILQNELREKDMRVALSDAFSLFSKGTRWRVAPYTDLLTGKEVSNHVSVFSDIHILGKFSLPVTDQEFPEKYRSIRFGRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83075</accession>
    <name>RSME_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber>2.1.1.193</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>16S rRNA m3U1498 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">rsmE</name>
        <name type="ordered locus">TP_0032</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71375">
        <property type="entry name" value="B71375"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881481.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83075"/>
    <dbReference type="SMR" id="O83075"/>
    <dbReference type="IntAct" id="O83075">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0032"/>
    <dbReference type="EnsemblBacteria" id="AAC65027">
        <property type="protein sequence ID" value="AAC65027"/>
        <property type="gene ID" value="TP_0032"/>
    </dbReference>
    <dbReference type="GeneID" id="57878574"/>
    <dbReference type="KEGG" id="tpa:TP_0032"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_1_0_12"/>
    <dbReference type="OMA" id="WQTPFLE"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000176218" description="Ribosomal RNA small subunit methyltransferase E">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="266" mass="29379" checksum="620974E04E8E4ED9" modified="1998-11-01" version="1">MNIVLFEQEEVVHGCAVLSFRDSRFCHIKRVLKLSAGACFKAGIINGVKGSARISLATEKYLVAVFEKLEYEDCALFPLHLVIGFPRPIQLRRILRDVSSLGISSIHLVGTELGERSYLDSGLAHMEKMHTYLIRGLEQAGGTKLPLITVSESVRTFCSQHTHILGDSTHQKLILDTKNTLTDLGSAALRGDVLWIAIGSERGWTESERLLFSAMGFRAVDMGRRTLRTETAACAACAVVLANAHAWKRKIPRPGKRSSPISRKNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-03-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83085</accession>
    <accession>R9UUU2</accession>
    <name>ADDL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative adenosine/adenine deaminase</fullName>
            <ecNumber>3.5.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">add</name>
        <name type="ordered locus">TP_0045</name>
        <name evidence="4" type="ORF">TPANIC_0045</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="PLoS ONE" volume="8" first="E74319" last="E74319">
            <title>Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.</title>
            <authorList>
                <person name="Petrosova H."/>
                <person name="Pospisilova P."/>
                <person name="Strouhal M."/>
                <person name="Cejkova D."/>
                <person name="Zobanikova M."/>
                <person name="Mikalova L."/>
                <person name="Sodergren E."/>
                <person name="Weinstock G.M."/>
                <person name="Smajs D."/>
            </authorList>
            <dbReference type="PubMed" id="24058545"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0074319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP004010">
        <property type="protein sequence ID" value="AGN75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71374">
        <property type="entry name" value="D71374"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881494.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83085"/>
    <dbReference type="SMR" id="O83085"/>
    <dbReference type="IntAct" id="O83085">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0045"/>
    <dbReference type="EnsemblBacteria" id="AAC65039">
        <property type="protein sequence ID" value="AAC65039"/>
        <property type="gene ID" value="TP_0045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75265">
        <property type="protein sequence ID" value="AGN75265"/>
        <property type="gene ID" value="TPANIC_0045"/>
    </dbReference>
    <dbReference type="GeneID" id="57878586"/>
    <dbReference type="KEGG" id="tpa:TP_0045"/>
    <dbReference type="KEGG" id="tpw:TPANIC_0045"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.48"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_2_0_12"/>
    <dbReference type="OMA" id="ANSKSIM"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000194396" description="Putative adenosine/adenine deaminase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9I6Y4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="AGN75265.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34543" checksum="9717F4430E65B1D8" modified="1998-11-01" version="1">MKSLEYYRSQPKADVHTHLNLSMKYERYKQWSGVVIPNFPRKMRGLDEMHEIIGEYTRPQCKTAQDVLNLFTMSIEDAIADNVVVMETSVDIGFITHYEENLDHFLCDLSDLHRRYKRNVTLHFELGISKIRERSFVEQWAEPMMRSGIFENIDLYGPEISEGIEDFIYIFKLAEKYHLKKKAHVGEFSDAQSVRHFVEIFNLDEVQHGIGAATDENVLRFLAERKVRCNVCPTSNVMLNAVECLEKHPIKKMMDAGVRVGLGTDDLLFFGKTNSEQLFDMVSCGLITELHAEALLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83086</accession>
    <name>O83086_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71372">
        <property type="entry name" value="A71372"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881496.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83086">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0047"/>
    <dbReference type="DNASU" id="2610799"/>
    <dbReference type="EnsemblBacteria" id="AAC65043">
        <property type="protein sequence ID" value="AAC65043"/>
        <property type="gene ID" value="TP_0047"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75267">
        <property type="protein sequence ID" value="AGN75267"/>
        <property type="gene ID" value="TPANIC_0047"/>
    </dbReference>
    <dbReference type="GeneID" id="57878588"/>
    <dbReference type="KEGG" id="tpa:TP_0047"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.43"/>
    <dbReference type="eggNOG" id="COG1728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1546883_0_0_12"/>
    <dbReference type="OMA" id="REDKHFI"/>
    <dbReference type="OrthoDB" id="1453685at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005585">
        <property type="entry name" value="DUF327"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024042">
        <property type="entry name" value="TM1646-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03885">
        <property type="entry name" value="DUF327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158397">
        <property type="entry name" value="SSF158397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19642" checksum="186C474CF7D2868B" modified="1998-11-01" version="1">MGYRVGNSDSTSLLSAFAPPERAKKKSKEKRPLQAARFLSLLYPKTDPHSAVQDPSLVHEEHQTRLAYLQDRLCSTGDILKNTRTLETIAAYKQAVKEFVQYAIKHNYTTESKSSIRIDRGTGMPDTVIFTKIKVIDQKLASFVRELMSHQVDQLTVLQKTEEIYGMLVDLLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>O83102</accession>
    <name>RS6_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsF</name>
        <name type="ordered locus">TP_0063</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71370">
        <property type="entry name" value="G71370"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881512.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83102"/>
    <dbReference type="SMR" id="O83102"/>
    <dbReference type="IntAct" id="O83102">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0063"/>
    <dbReference type="EnsemblBacteria" id="AAC65058">
        <property type="protein sequence ID" value="AAC65058"/>
        <property type="gene ID" value="TP_0063"/>
    </dbReference>
    <dbReference type="GeneID" id="57878603"/>
    <dbReference type="KEGG" id="tpa:TP_0063"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_1_12"/>
    <dbReference type="OMA" id="RYMILVK"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176867" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="93" mass="10916" checksum="B2E8AD8F5E80ACC3" modified="1998-11-01" version="1">MRTYELMAVFSAHEDLFLQGSTAVRALLQENDAVIAREDHIGERELAYPLKKQKRGRYLLFIVQCEPGKVRELDHKLRLRHDLLTHLFVRVDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83107</accession>
    <name>RLMN_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN</name>
        <name type="ordered locus">TP_0068</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1585371">
            <id>O83107</id>
        </interactant>
        <interactant intactId="EBI-1582351">
            <id>O83970</id>
            <label>dnaX</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71371">
        <property type="entry name" value="D71371"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881517.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83107"/>
    <dbReference type="SMR" id="O83107"/>
    <dbReference type="IntAct" id="O83107">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0068"/>
    <dbReference type="EnsemblBacteria" id="AAC65061">
        <property type="protein sequence ID" value="AAC65061"/>
        <property type="gene ID" value="TP_0068"/>
    </dbReference>
    <dbReference type="GeneID" id="57878608"/>
    <dbReference type="KEGG" id="tpa:TP_0068"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_0_0_12"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000350509" description="Probable dual-specificity RNA methyltransferase RlmN">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="97"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="104"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="340" mass="37520" checksum="4F1F0332758CF721" modified="1998-11-01" version="1">MEWCCALSGLLPEEIQKVCAFAERFRGVQVFRWIAAGCTDFHAMSDLSSETRARLARACVISDTRVYTTLRDVDGTLKLGIELKDKRRVEAVLLVDQVSRKTACLSCQVGCPMACAFCQTGQLGFARNLSASEIVEQFLHLERCVGTLDNVVFMGMGEPMLNLDAVCRAIEILSHPQGRDLSEKRITISTSGHCRGIYSLADRALQVRLAVSLTTANAPLRARLMPRAAHDSLAKLKSAIRYFNEKSGKRVTLELALMRGVNTSERHAQEVIDFAHGLNVHVNLIPWNPVASIHFETPREVEVAHFEALLMRARIPVTRRYQRGNGIGGACGQLGKTAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83115</accession>
    <name>O83115_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter, permease protein (Y4oR)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71369">
        <property type="entry name" value="C71369"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881525.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0076"/>
    <dbReference type="EnsemblBacteria" id="AAC65071">
        <property type="protein sequence ID" value="AAC65071"/>
        <property type="gene ID" value="TP_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0076"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.84"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_12"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="273" mass="30268" checksum="0AE3B5B8595A5D99" modified="1998-11-01" version="1">MNMIFLKWRTALVLCLLSCIALVSMFPLYEMVATSLKRDADAFRLPPAWFFIPTIENYRQLLQEHHFGRALYNSLVVTLSSTVVSVSAGAAAAYAMQRFRYRGKKAITVALLLLRVIPPVVLVIPIFVWWTALGLVNSLAGLALVYGALNVPFNVWVITTFVAEIPPSLDESAKLDGCSHWMIFTRIVMPLITPALALVSIFTFRFAWNEYMLGFALTNRKTRTLPVALSLFLTDSGVEWGRITAAATLIAIPACVFTFAAAKYLVVGLTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83127</accession>
    <name>O83127_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71368">
        <property type="entry name" value="B71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881538.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83127">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0089"/>
    <dbReference type="EnsemblBacteria" id="AAC65084">
        <property type="protein sequence ID" value="AAC65084"/>
        <property type="gene ID" value="TP_0089"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75308">
        <property type="protein sequence ID" value="AGN75308"/>
        <property type="gene ID" value="TPANIC_0089"/>
    </dbReference>
    <dbReference type="GeneID" id="57878629"/>
    <dbReference type="KEGG" id="tpa:TP_0089"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.89"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694328_0_0_12"/>
    <dbReference type="OMA" id="ERIWFIY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="199"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="411" mass="46822" checksum="D56C70EA0C3A2E7D" modified="1998-11-01" version="1">MLQLTFVNFKKGSYILVEGKADADLFYIIHSGQVCIAKQVEIVAEEEGNVLTAGNFLGVVACMSRHNQIETAVALTDVVLIAIRYEQFPQLIEKNAAIAMKIILSFTKKMRYLNEALTQLTLKKHTDVDVSHLFAIGEYYVKMTKFELALYAYYHYLKESPKGTYAEEARKRFVAIKSTGVKVPVEILEPNILEATRCYDREAMVFCECQLGNEFYIIQKGHVKITKIVDNNEVVLAILKEGDMFGEMALLENKPRSASAIVMSDGCQLLAVNRKNFQQLVATQPQLTARLTTTLADRIWSMYRQLANTLLPEPTEKMYDMLAIQLEKIRYIPSTGKAYDFEFGPIELAHMCGFPKDIVSQVTEDFLREPIVRCVDNKISVTDDLELVKRVAYFKKKRTLAKARKDPHNRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="137" xmlns="http://uniprot.org/uniprot">
    <accession>O83129</accession>
    <name>SYC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Cysteine--tRNA ligase</fullName>
            <ecNumber>6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cysteinyl-tRNA synthetase</fullName>
            <shortName>CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">cysS</name>
        <name type="ordered locus">TP_0091</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71368">
        <property type="entry name" value="D71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881540.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83129"/>
    <dbReference type="SMR" id="O83129"/>
    <dbReference type="IntAct" id="O83129">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0091"/>
    <dbReference type="EnsemblBacteria" id="AAC65085">
        <property type="protein sequence ID" value="AAC65085"/>
        <property type="gene ID" value="TP_0091"/>
    </dbReference>
    <dbReference type="GeneID" id="57878631"/>
    <dbReference type="KEGG" id="tpa:TP_0091"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_12"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159511" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="520" mass="58403" checksum="6DF2704F7AF2C50E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83131</accession>
    <name>Y093_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0093</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0093</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71368">
        <property type="entry name" value="F71368"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881542.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83131"/>
    <dbReference type="SMR" id="O83131"/>
    <dbReference type="STRING" id="243276.TPANIC_0093"/>
    <dbReference type="EnsemblBacteria" id="AAC65089">
        <property type="protein sequence ID" value="AAC65089"/>
        <property type="gene ID" value="TP_0093"/>
    </dbReference>
    <dbReference type="GeneID" id="57878633"/>
    <dbReference type="KEGG" id="tpa:TP_0093"/>
    <dbReference type="eggNOG" id="ENOG5032N9X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282735_0_0_12"/>
    <dbReference type="OMA" id="RREICAH"/>
    <dbReference type="OrthoDB" id="1494577at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000202189" description="Uncharacterized protein TP_0093">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="215" mass="23443" checksum="E005308CEE3D1E05" modified="1998-11-01" version="1">MRTCPDCAAWCAYVDGEGSQLQRREMCAHLQGCTHCATCVAHYRAMRSLVKHADRVSSRDFTMAFPYLRVRHRVASCMPRPWWQARSSPLSAAGPVRAAALAVAVASLCVCTLLLTHIVERRPVSRAGEASFTPIVPMRVRAPVGYARGVKVFGPAVSANSNVLRKPAAVFTVCAFAQLYGSDPAYEMETVPVRLSVIPVPSYVLNASKAQFFSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83135</accession>
    <name>IF1_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">TP_0097</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71366">
        <property type="entry name" value="E71366"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881546.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83135"/>
    <dbReference type="SMR" id="O83135"/>
    <dbReference type="IntAct" id="O83135">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0097"/>
    <dbReference type="EnsemblBacteria" id="AAC65092">
        <property type="protein sequence ID" value="AAC65092"/>
        <property type="gene ID" value="TP_0097"/>
    </dbReference>
    <dbReference type="GeneID" id="57878637"/>
    <dbReference type="KEGG" id="tpa:TP_0097"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_12"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000095897" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8288" checksum="3A362A2CB0F762CF" modified="1998-11-01" version="1">MTKEEAIEVDGVVKEALPNTTFRVQLQNGHEILAYLSGRMRKHYIRIVPGDSVKVALSPYDLSRGRIMFRER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83152</accession>
    <name>HFLC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hflC</name>
        <name type="ordered locus">TP_0114</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71365">
        <property type="entry name" value="A71365"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881563.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83152"/>
    <dbReference type="SMR" id="O83152"/>
    <dbReference type="IntAct" id="O83152">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0114"/>
    <dbReference type="MEROPS" id="I87.001"/>
    <dbReference type="EnsemblBacteria" id="AAC65104">
        <property type="protein sequence ID" value="AAC65104"/>
        <property type="gene ID" value="TP_0114"/>
    </dbReference>
    <dbReference type="GeneID" id="57878657"/>
    <dbReference type="KEGG" id="tpa:TP_0114"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059167_3_0_12"/>
    <dbReference type="OMA" id="DFFAFYR"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01932">
        <property type="entry name" value="hflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000094078" description="Protein HflC">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="331" mass="37594" checksum="6D478740B1756542" modified="1998-11-01" version="1">MRKRGLQVHARVRPVLNIGIVVGVLLGGVVLLQPFYLIQEGQVALITQFGEIIKTNNTAGLYVRAPFLHHVHKYTAKLLRVDGDPQKIPTKEKQFIEVDTTSRWRIEDVKKFYQSLGTYEAAYSRISDIIDSSVRDIITVNGLDDVVRSTNAINESNHSEQFDVPVSQLAFDRGAEKTAHMTIEKGRESLAREISQAANDQLKDFGIVVVDVIFKGIKYSDELQASVFNRMVKERNQIAQMFRSTGEGKKAEWLGKLDNEKRSLLSKAYEEAERIKGEADARAAAVYAQSYGKSPEFYGFWKSLEVYKKSLPDTEKILSTDLEYFKHLYQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>O83168</accession>
    <name>Y132_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0132</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0132</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71363">
        <property type="entry name" value="A71363"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83168"/>
    <dbReference type="IntAct" id="O83168">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65123">
        <property type="protein sequence ID" value="AAC65123"/>
        <property type="gene ID" value="TP_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0132"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.141"/>
    <dbReference type="HOGENOM" id="CLU_2866500_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202196" description="Uncharacterized protein TP_0132">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <sequence length="69" mass="7674" checksum="4E01BAE85031F6A3" modified="1998-11-01" version="1">MEPRMSGSNLRFPYSRAYGGAGVGRNFEKSSRFSVQKEGIGAPGSARTALQFKLFLLSRLFFIFTSHIP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>O83185</accession>
    <name>Y150_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0150</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71361">
        <property type="entry name" value="G71361"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83185"/>
    <dbReference type="IntAct" id="O83185">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0150"/>
    <dbReference type="EnsemblBacteria" id="AAC65142">
        <property type="protein sequence ID" value="AAC65142"/>
        <property type="gene ID" value="TP_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0150"/>
    <dbReference type="eggNOG" id="ENOG5032J02">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694721_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014239" description="Uncharacterized protein TP_0150">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="155" mass="17288" checksum="91644BACD38CC227" modified="1998-11-01" version="1" precursor="true">MTYNTNTSLSSYAGLSAFALSVFCILWGTARTGSFLKEKALITCAADILARQAPELGVTSRTLRMVPSSPIPQAEVLRGKKNTGEEIFLYFFPLRGMYGSFPTLFLYDKKDGARFCHLIGNHPTPRDARFYGISSARIALQCRKIEHLHQTVAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83189</accession>
    <name>O83189_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71358">
        <property type="entry name" value="H71358"/>
    </dbReference>
    <dbReference type="IntAct" id="O83189">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0154"/>
    <dbReference type="EnsemblBacteria" id="AAC65144">
        <property type="protein sequence ID" value="AAC65144"/>
        <property type="gene ID" value="TP_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0154"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_1_0_12"/>
    <dbReference type="OMA" id="HAFLVKF"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="345" mass="37537" checksum="41D6A6483A60378D" modified="1998-11-01" version="1">MDVVPPVSTVRPHGGAAVECFRCTKNDAGRRVDRVLRILLPACPRVGVYARVRRTAIRLNGRPVQPAKRVQVGDVLSLPESLCRARAASSRLSKMPGTPKLRVLPSVVFKTQDLLFFHKPAGLCVHGPRSLDAWVRGQGRAHVPPALSFRPGPLHRLDRGTEGLIAFSRSLRGAQWFSAALQQHTLRKFYLAITAAPARTAAAARTLVRPGEVTHVQTVLHSCDSALVLRVIVPVTGKKHQIRRYCAAQGFPLVGDRTYGGASQHGNARYTRFFLLAWCVRFPSSRLQALPAQVWTTPSPAFMRVLTSFPPDSLARARACVDALDGALGTDATCPQDTAVCTPEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83209</accession>
    <name>Y179_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0179</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0179</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71353">
        <property type="entry name" value="E71353"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881626.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83209"/>
    <dbReference type="SMR" id="O83209"/>
    <dbReference type="STRING" id="243276.TPANIC_0179"/>
    <dbReference type="PRIDE" id="O83209"/>
    <dbReference type="EnsemblBacteria" id="AAC65193">
        <property type="protein sequence ID" value="AAC65193"/>
        <property type="gene ID" value="TP_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0179"/>
    <dbReference type="eggNOG" id="ENOG503478X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422064_0_0_12"/>
    <dbReference type="OMA" id="SHDAPEY"/>
    <dbReference type="OrthoDB" id="1540397at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202210" description="Uncharacterized protein TP_0179">
        <location>
            <begin position="1"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="627" mass="66536" checksum="5A4E016431987661" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83230</accession>
    <name>RL24_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">TP_0200</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71356">
        <property type="entry name" value="B71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881647.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83230"/>
    <dbReference type="SMR" id="O83230"/>
    <dbReference type="STRING" id="243276.TPANIC_0200"/>
    <dbReference type="EnsemblBacteria" id="AAC65185">
        <property type="protein sequence ID" value="AAC65185"/>
        <property type="gene ID" value="TP_0200"/>
    </dbReference>
    <dbReference type="GeneID" id="57878738"/>
    <dbReference type="KEGG" id="tpa:TP_0200"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_12"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130744" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="103" mass="11572" checksum="B8FBDDC4077F3E0F" modified="1998-11-01" version="1">MGKTVKIRKDDMVLVIAGKDRGKRGAVLRVLRDVDRVLVQGLNMRKKTIRRKSAQDEGGIMEVEAPIHISNVMIMGKKGPTRVGYRMENGKKVRVCRKTGEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83234</accession>
    <name>RL6_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">TP_0204</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71356">
        <property type="entry name" value="F71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881651.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83234"/>
    <dbReference type="SMR" id="O83234"/>
    <dbReference type="STRING" id="243276.TPANIC_0204"/>
    <dbReference type="EnsemblBacteria" id="AAC65188">
        <property type="protein sequence ID" value="AAC65188"/>
        <property type="gene ID" value="TP_0204"/>
    </dbReference>
    <dbReference type="GeneID" id="57878741"/>
    <dbReference type="KEGG" id="tpa:TP_0204"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_12"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131074" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="179" mass="19425" checksum="44134E4529E1EBA4" modified="1998-11-01" version="1">MSRIGKVPVSVPGGVHVRVSSGVVEVEGPKGVLSCAFLPVVTVRVEQEYVIVARCDDSKRARACHGLYRKLLSNMVVGVSEGFSKTLVITGIGYRAEVQGRVLVMALGYSNDFTVLIPSGIEVRVESSTRVIVSGVSKERVGEFAAQLRRLRLPEAYKGKGIRYDYETIVRKVGKSGVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83236</accession>
    <name>RS5_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">TP_0206</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71356">
        <property type="entry name" value="H71356"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881653.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83236"/>
    <dbReference type="SMR" id="O83236"/>
    <dbReference type="IntAct" id="O83236">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0206"/>
    <dbReference type="EnsemblBacteria" id="AAC65190">
        <property type="protein sequence ID" value="AAC65190"/>
        <property type="gene ID" value="TP_0206"/>
    </dbReference>
    <dbReference type="GeneID" id="57878743"/>
    <dbReference type="KEGG" id="tpa:TP_0206"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_12"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131625" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="172" mass="18590" checksum="FD8CB140449942A2" modified="1998-11-01" version="1">MDRHRDFGKDRLRDKEFTEKLIKLNRTAKVVKGGRRFSFSALTVVGDQKGRVGFGFGKAGDVSEAIRKSVERAKRSMVLFPLKDGTIPHEVQAKFKGSLVLLRPACSGTGIIAGGTVRAIMEVAGATDVLSKSLGSNSAINVVRATFGAVAQLMDARKLARERGKALVDMWG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83247</accession>
    <name>O83247_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor SigB regulation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71352">
        <property type="entry name" value="G71352"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881666.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83247">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0218"/>
    <dbReference type="EnsemblBacteria" id="AAC65205">
        <property type="protein sequence ID" value="AAC65205"/>
        <property type="gene ID" value="TP_0218"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75432">
        <property type="protein sequence ID" value="AGN75432"/>
        <property type="gene ID" value="TPANIC_0218"/>
    </dbReference>
    <dbReference type="GeneID" id="57878756"/>
    <dbReference type="KEGG" id="tpa:TP_0218"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.222"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564906_0_0_12"/>
    <dbReference type="OMA" id="KMTIRYV"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="272"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="489" mass="56170" checksum="7739E27194241A1D" modified="1998-11-01" version="1">MIRRRLAIVKAGSFALLALFFSIFLRFLSPRYSFLGRFVSARDMALLISRYEHLPELSSRDRALLVGFVFMIFALALTEIQRYAHGRIRLVVYRQTETRLFEHFITLLRFCYRNEQLVAAFQEVLEYRADCAVLLMDTISNRVIYNSAARFVSDTRTYDLVLHKFSMDYTWHWSDGIYFFDDDLCLMSDRRRARGVCLSSGELRLFIVCRFIRAVEREVISLLFKEFEEYLNRKRNMSTLLLYSHVSQEWAMMARVQRALLPKALPHTKEICVGAFYQPLVNVSGDYYDVISIDEHLFLFVIGDVSGKGLAASLVMGVVLSTIRIVEDKKNLPEILYAVDRAVKRMHLHDKYTTLFLGLIDTAGMNIRYINASMESPLVFTQAGEAHEVYHLHSNCPVIGIVDLPPIQIHERTLCPGDVMVMVSDGVVEVVNAQGVELRDADEYLHILERHVGEHPAQMAQSIAALALNFSADRTTHDDMTIVTVQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>O83255</accession>
    <name>O83255_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71351">
        <property type="entry name" value="A71351"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881675.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83255">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0227"/>
    <dbReference type="EnsemblBacteria" id="AAC65214">
        <property type="protein sequence ID" value="AAC65214"/>
        <property type="gene ID" value="TP_0227"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75440">
        <property type="protein sequence ID" value="AGN75440"/>
        <property type="gene ID" value="TPANIC_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0227"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.231"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="YALELCP"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="255" mass="27321" checksum="0EEA29017B62A15E" modified="1998-11-01" version="1">MSADVAADTAVESCAGPLLELVNVSKSFERDCEVLHSVSFRVFPGDCVVLAGANGSGKTVLMNILAGLEPPSSGRVYMARGTTVGLAFQNADTQILGETVFEDCAFGPLQWGYSRAEIDARTNSALAAVSLLDRRDHYARALSGGEKRRLTVAGVLALDAKVVILDEPFANLDYPSVRQVVQLIISLKHAGKTLVIITHEVEKILAAATRLCILSKGVISYDGTPQDALDSKIFSCYGLRDPLHCPLTLSDLLWT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83256</accession>
    <name>BIOY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Probable biotin transporter BioY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">bioY</name>
        <name type="ordered locus">TP_0228</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable biotin transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71351">
        <property type="entry name" value="B71351"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83256"/>
    <dbReference type="SMR" id="O83256"/>
    <dbReference type="IntAct" id="O83256">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0228"/>
    <dbReference type="EnsemblBacteria" id="AAC65216">
        <property type="protein sequence ID" value="AAC65216"/>
        <property type="gene ID" value="TP_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0228"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_3_0_12"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000144147" description="Probable biotin transporter BioY">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="271" mass="28773" checksum="462EE7EAA4524A2D" modified="1998-11-01" version="1">MHRTEPTINCVHDGTRSLHLSIDTTRALPAHSGNEPTRTHLAAVRVSLLKTIPVAPPKILKDSSFRVTLRIDPSEEYCTMHRSKSLAFVALFAALISSSALVSIPLKPVPLVLQNAAAVLTGLLLGPRDGALAVLSFLGAGLLGLPVFSGGRGGYTALFAPTGGFLLGYILAATLAGAIAQHHRLSCTPPRGGGRALLLWIRLTVATLVGFLSIYSIGLPVLGYVLGLRTGELMLGVFLPFFLADTLKIALVVLLAHHLAPTVRRHLYRHG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83258</accession>
    <name>PRIA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Primosomal protein N'</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">priA</name>
        <name type="ordered locus">TP_0230</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71351">
        <property type="entry name" value="D71351"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881678.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83258"/>
    <dbReference type="SMR" id="O83258"/>
    <dbReference type="STRING" id="243276.TPANIC_0230"/>
    <dbReference type="PRIDE" id="O83258"/>
    <dbReference type="EnsemblBacteria" id="AAC65217">
        <property type="protein sequence ID" value="AAC65217"/>
        <property type="gene ID" value="TP_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0230"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_0_12"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0639">Primosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000102136" description="Primosomal protein N'">
        <location>
            <begin position="1"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="390"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <sequence length="657" mass="72168" checksum="64D8423F390577DD" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>O83282</accession>
    <name>O83282_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71346">
        <property type="entry name" value="G71346"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881707.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83282">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0258"/>
    <dbReference type="EnsemblBacteria" id="AAC65247">
        <property type="protein sequence ID" value="AAC65247"/>
        <property type="gene ID" value="TP_0258"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75470">
        <property type="protein sequence ID" value="AGN75470"/>
        <property type="gene ID" value="TPANIC_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0258"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.278"/>
    <dbReference type="eggNOG" id="ENOG5033D2Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102574_0_0_12"/>
    <dbReference type="OMA" id="YKRNIFF"/>
    <dbReference type="OrthoDB" id="1391139at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="236" mass="28124" checksum="46AD43A7F7936D76" modified="1998-11-01" version="1">MLSLGPFHRKGWHCNSLRIRTQSTETVTNVGARSFRSAVFTLLTTVCALCGDPAHAYLVQFKEQFYRLYHTHLHQYPDEVIENIHWLERAVHADFANPLYALAPIRDKKSWEKYRALFMMHLNLKLTEQHLRLGEKFDKREALFFNAPWREENIESLATAERCYHTARRYWHEAALWAERANADQFRFLFLTELPAWEDERERIARGTLNYARTISRELARLEAVRARFMEMNDTY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83307</accession>
    <name>COAD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="synonym">kdtB</name>
        <name type="ordered locus">TP_0283</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71343">
        <property type="entry name" value="F71343"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881732.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83307"/>
    <dbReference type="SMR" id="O83307"/>
    <dbReference type="IntAct" id="O83307">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0283"/>
    <dbReference type="EnsemblBacteria" id="AAC65267">
        <property type="protein sequence ID" value="AAC65267"/>
        <property type="gene ID" value="TP_0283"/>
    </dbReference>
    <dbReference type="GeneID" id="57878824"/>
    <dbReference type="KEGG" id="tpa:TP_0283"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_1_1_12"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156300" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="159" mass="17805" checksum="BEEC7CDF9BB73160" modified="1998-11-01" version="1">MKAIFAGSFDPPTFGHLDLVLRARSLFAEVHVLVAVNVQKRYLLSECERVDLMRQVLGDRPGVYVFPWRSLVVTYARDVGARVLVRGVRNATDFCQEFDLAWVHRALDAGLETVFLAAKPCYAALRSSMVREVASFGGDVSTFVPRVVARLLQEKFTQA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83325</accession>
    <name>MUTL_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">mutL</name>
        <name type="ordered locus">TP_0303</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65291" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65291.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71342">
        <property type="entry name" value="A71342"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83325"/>
    <dbReference type="SMR" id="O83325"/>
    <dbReference type="IntAct" id="O83325">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0303"/>
    <dbReference type="EnsemblBacteria" id="AAC65291">
        <property type="protein sequence ID" value="AAC65291"/>
        <property type="gene ID" value="TP_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0303"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_1_12"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177988" description="DNA mismatch repair protein MutL">
        <location>
            <begin position="1"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="620" mass="68496" checksum="0604AD802671EA36" modified="2000-05-30" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>O83333</accession>
    <name>Y311_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0311</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0311</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71340">
        <property type="entry name" value="A71340"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83333"/>
    <dbReference type="EnsemblBacteria" id="AAC65304">
        <property type="protein sequence ID" value="AAC65304"/>
        <property type="gene ID" value="TP_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0311"/>
    <dbReference type="HOGENOM" id="CLU_3174440_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202231" description="Uncharacterized protein TP_0311">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <sequence length="47" mass="5057" checksum="A8532D4C207FAEFD" modified="1998-11-01" version="1">MTGELMLRLPCWSSFCEKTHPPLHPGTSLSSTASIACATHPHHTKGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83340</accession>
    <name>Y320_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0320</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0320</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71341">
        <property type="entry name" value="A71341"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83340"/>
    <dbReference type="IntAct" id="O83340">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0320"/>
    <dbReference type="TCDB" id="3.A.1.2.10">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65308">
        <property type="protein sequence ID" value="AAC65308"/>
        <property type="gene ID" value="TP_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0320"/>
    <dbReference type="HOGENOM" id="CLU_3159008_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202235" description="Uncharacterized protein TP_0320">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <sequence length="51" mass="5332" checksum="F93DE6DB7ADB4381" modified="1998-11-01" version="1">MPPVPARGRPSSSSDFCLYGMAVVNGFCVQDIPYGSRVVLPGRMRSSSAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="136" xmlns="http://uniprot.org/uniprot">
    <accession>O83341</accession>
    <name>O83341_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose/galactose ABC transporter, ATP-binding protein (RbsA-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71338">
        <property type="entry name" value="D71338"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881769.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0321"/>
    <dbReference type="TCDB" id="3.A.1.2.10">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65309">
        <property type="protein sequence ID" value="AAC65309"/>
        <property type="gene ID" value="TP_0321"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75521">
        <property type="protein sequence ID" value="AGN75521"/>
        <property type="gene ID" value="TPANIC_0321"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0321"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.320"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_12"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="260"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="533" mass="58033" checksum="D04AE26D6FDB1322" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83350</accession>
    <name>O83350_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71336">
        <property type="entry name" value="H71336"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881778.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83350">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0330"/>
    <dbReference type="EnsemblBacteria" id="AAC65318">
        <property type="protein sequence ID" value="AAC65318"/>
        <property type="gene ID" value="TP_0330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75529">
        <property type="protein sequence ID" value="AGN75529"/>
        <property type="gene ID" value="TPANIC_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0330"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.346"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437284_0_0_12"/>
    <dbReference type="OMA" id="YRGKIIW"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="342"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="598" mass="67756" checksum="60563B69D67EDCD9" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83354</accession>
    <name>O83354_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71337">
        <property type="entry name" value="D71337"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881782.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83354">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0334"/>
    <dbReference type="EnsemblBacteria" id="AAC65321">
        <property type="protein sequence ID" value="AAC65321"/>
        <property type="gene ID" value="TP_0334"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75532">
        <property type="protein sequence ID" value="AGN75532"/>
        <property type="gene ID" value="TPANIC_0334"/>
    </dbReference>
    <dbReference type="GeneID" id="57878865"/>
    <dbReference type="KEGG" id="tpa:TP_0334"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.332"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743750_0_0_12"/>
    <dbReference type="OMA" id="VFRASMR"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="405" mass="45308" checksum="936984448342E726" modified="1998-11-01" version="1">MPDIGELLKTTRERKHLSLEQAAHETSIARRYLEALENDEYDVFPGEPYILGFLRNYCEYLQLDTEQCIARYKHLKIQEMSLPTETLLPSKRWGSFPLLKGVACVLFLGGVLGVYYARHRALGFLSRIVFFGRAQRTPRELSPPDATGAVRETVSLSSAQHEERARRTRSSASRYTLAEEKFEHTVFPGDVLVISSGGNAYELTVSRTTPHLYLDTPIGTQVISLGQRLVMDLNTDVQPDVEISVEDIEAHQADGGARVRVFTGSLVQTLRDRSAQSFVPTSGVNVSGQTGVAAGARYQVLFEGGVAYPVTMNATFRSYCLFRYEADRTRREERYYQKGEQLTVQANNGIRVWASNGNVVQLQIVAGGKTVDVGLSRPGEVLVKDIKWIKDEDAGRFKFVVMEVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83365</accession>
    <name>MRAY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">TP_0345</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71335">
        <property type="entry name" value="H71335"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881793.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83365"/>
    <dbReference type="SMR" id="O83365"/>
    <dbReference type="IntAct" id="O83365">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0345"/>
    <dbReference type="EnsemblBacteria" id="AAC65333">
        <property type="protein sequence ID" value="AAC65333"/>
        <property type="gene ID" value="TP_0345"/>
    </dbReference>
    <dbReference type="GeneID" id="57878875"/>
    <dbReference type="KEGG" id="tpa:TP_0345"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857073_0_0_12"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000108919" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="363" mass="40558" checksum="EBAF04B32793946A" modified="1998-11-01" version="1">MGLIFFRYDRCYMLSVLSYLHVYFGPFRLLQSYAVLMGIALYAGFFFTYGVLPSAYRFLPQDRGRAFAPCAQEAAGKPTGAGVIFVSVFVLLVYLLMRPSFVHALILLLTWGVMLTGYLDDCAQVCWGEYRKGALDFLFAVLTAALLGHFYFHDQVFWWFPFFSDPVFVSPFLFFAGSVVILWMSINATNCTDGVDGLSGALVLMALLSMGTIFYFLLGNVRAAQYLLVPFVVDGAQWALMSFALAGALMGYVWRNAHPSTVLMGDAGSRALGFFIGVLVLISGNPFLLLMTSGVILVNGGTGLLKVVLLRFFHVRILSRVRFPLHDHMRENWHWSTAQVLLRFMILQGLLTIGLLGVLFKLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-10-10" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>O83373</accession>
    <name>KTHY_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative thymidylate kinase</fullName>
            <ecNumber>2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tmk</name>
        <name type="ordered locus">TP_0354</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Could be inactive due to a defective ATP-binding site.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71333">
        <property type="entry name" value="H71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881802.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83373"/>
    <dbReference type="SMR" id="O83373"/>
    <dbReference type="IntAct" id="O83373">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0354"/>
    <dbReference type="PRIDE" id="O83373"/>
    <dbReference type="EnsemblBacteria" id="AAC65341">
        <property type="protein sequence ID" value="AAC65341"/>
        <property type="gene ID" value="TP_0354"/>
    </dbReference>
    <dbReference type="GeneID" id="57878884"/>
    <dbReference type="KEGG" id="tpa:TP_0354"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_3_12"/>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155363" description="Putative thymidylate kinase">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Defective ATP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="208" mass="23948" checksum="E0186BAF9949896D" modified="1998-11-01" version="1">MNILHNFVVFEGIDGTGTSTQLRALERHFQARKDMVFTQEPTGGEIGTLIRDVLQKRVIMSSKALGLLFAADRHEHLEGAGGINDCLAEGKIVLCDRYVFSSLVYQGMAVSGSFAYELNKEFPLPEVVFYFDAPIEVCVERITARGLQTELYEYTSFQEKARKGYETIFRKCRHLYPAMKVIEIDAREEIEVVHERILHHLREYRRLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>O83374</accession>
    <name>Y355_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0355</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0355</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71334">
        <property type="entry name" value="A71334"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881803.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83374"/>
    <dbReference type="SMR" id="O83374"/>
    <dbReference type="EnsemblBacteria" id="AAC65353">
        <property type="protein sequence ID" value="AAC65353"/>
        <property type="gene ID" value="TP_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="57879571"/>
    <dbReference type="KEGG" id="tpa:TP_0355"/>
    <dbReference type="HOGENOM" id="CLU_1969551_0_0_12"/>
    <dbReference type="OMA" id="IVYLRPH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202240" description="Uncharacterized protein TP_0355">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="127" mass="14527" checksum="1B848EF0DAC4ADC4" modified="1998-11-01" version="1">MQGSVQIQKGNISSSYTPEKHPSHPTSANGSMSPKRICELRKEDPSSLHKQLLKNSLEKGTEHCDRTTKTYGQIFQLFCLCCAGAAPFYRARAFRLQSTFLIYTLHCSSDSVSTSTHYFRRLYSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>O83376</accession>
    <name>O83376_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71334">
        <property type="entry name" value="C71334"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0357"/>
    <dbReference type="EnsemblBacteria" id="AAC65343">
        <property type="protein sequence ID" value="AAC65343"/>
        <property type="gene ID" value="TP_0357"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75554">
        <property type="protein sequence ID" value="AGN75554"/>
        <property type="gene ID" value="TPANIC_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0357"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.356"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_5_2_12"/>
    <dbReference type="OMA" id="HGSPIFH"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26208" checksum="621521AD7EADB1C5" modified="1998-11-01" version="1">MCVAVCLVPVRNPFGASVYFAPKTASTMDEAASRAQGCEEGAVFCAGEQVAGRGRGDQRKWQSEPGKNLLCTVVLRRVAFPAFSLCVGYAVALAYMAFLGGVCAPRIKWPNDVLVCDRKIAGVLCQVRAGALLVGIGCNLLQVKFPPELSHACSLAQIVGGERCPDPFAFLPVLLDRLYACVMAPPSIGVLESCLWKQGEYVCFRECAGTRPPILGRVVGLAADGALCIDSAGSMRSYYSGEIAFW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83386</accession>
    <name>ISPE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">TP_0371</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71333">
        <property type="entry name" value="B71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881819.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83386">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0371"/>
    <dbReference type="EnsemblBacteria" id="AAC65356">
        <property type="protein sequence ID" value="AAC65356"/>
        <property type="gene ID" value="TP_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0371"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_2_0_12"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189282" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="291" mass="31592" checksum="410EC57910C3B81C" modified="1998-11-01" version="1">MQSLSLRAHAKVNMHLWVGARRADGLHSIESVMQRITLADSLSLSRLDIPGRCEVCSPYMALPRENTLTRAYARFCQVTGVHDGVRVRVVKRIPAGSGLGGGSADAAALLCGLDTLFGTTLSARVLREVAYSVGSDVPFFLASQAACVLGGGEQLVPLVPKTGYLGLLVWPGLHSGSAQAYEDLDRLRACGVHAADGEQYSLRGATALSAHYAQDCARWRFFNSLDAPVQRRYPVVALARWDLARAGACFTAMSGSGSXVFGLYRDEEELRRAHKLLAKRWCWCVRVRLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="138" xmlns="http://uniprot.org/uniprot">
    <accession>O83395</accession>
    <name>O83395_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71330">
        <property type="entry name" value="F71330"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881828.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
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        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0380"/>
    <dbReference type="EnsemblBacteria" id="AAC65366">
        <property type="protein sequence ID" value="AAC65366"/>
        <property type="gene ID" value="TP_0380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75575">
        <property type="protein sequence ID" value="AGN75575"/>
        <property type="gene ID" value="TPANIC_0380"/>
    </dbReference>
    <dbReference type="GeneID" id="57878907"/>
    <dbReference type="KEGG" id="tpa:TP_0380"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.380"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="250"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="460"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="606" mass="67598" checksum="9732D6DB4693809C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83402</accession>
    <name>O83402_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein (FtsW)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_0387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71331">
        <property type="entry name" value="E71331"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881835.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83402">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0387"/>
    <dbReference type="EnsemblBacteria" id="AAC65371">
        <property type="protein sequence ID" value="AAC65371"/>
        <property type="gene ID" value="TP_0387"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75581">
        <property type="protein sequence ID" value="AGN75581"/>
        <property type="gene ID" value="TPANIC_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0387"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.387"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_1_2_12"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="384" mass="42715" checksum="01DF27E5E30B4F2E" modified="1998-11-01" version="1">MRPMISIEKNVHQERYSFVFILLVALMVGVGFVTLYSGSVHYAQRFFRYPGYFLVRQGVSIGIGLVCLLFFTFVRLASLRKALSPLILVAFALCVCTFFPGIGSTRNGATRWIKVFDINFQPSEFVKLVLIVFLANFFDKHREHFDTPIRSIFPPFVVSVIFVSVVFFQNDFSTAMFLLFITVVMFFIAGAPLWWFLRGIMVLAPIAVLMIVTSTNRLRRVLSFLYPDRDPLGAGYQVNAALEALMDGGLWGRGIGNGVRKIASVPEVYSDFIFVVIGEEMGFIGVCLYLMLLFAFTLTGISIALRCANRFNTFLAFGASAAIVLQSILNVAVVVRLVPATGIPLPFFSSGGSSIVVTLSLCGLIINVSGDEKIRREREETVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83404</accession>
    <name>O83404_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">TP_0389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71331">
        <property type="entry name" value="G71331"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881837.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83404">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0389"/>
    <dbReference type="EnsemblBacteria" id="AAC65373">
        <property type="protein sequence ID" value="AAC65373"/>
        <property type="gene ID" value="TP_0389"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75583">
        <property type="protein sequence ID" value="AGN75583"/>
        <property type="gene ID" value="TPANIC_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0389"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.413"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_12"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="414" mass="44235" checksum="D0FB22B0C49E903A" modified="1998-11-01" version="1">MGEVIVGLDIGTESIRAVVAERLEGGALQVVGVGVGHSKGLRRGVVVNIENTVVGIHHAVEAAEMMSGIEVAHCVVGLGGTHIEGRNLKGVVAVADKGKGHREVDQSDIDRVLEVACAVSLPPDRKILHVIPKVYSVDDQHGITDPRNIIGVRLEGEVHMITGSATCMRSVIDCVKRANLHIDFLMHNGLAAVRSVLNDDERNVGCVLINIGGGTTDVIAMYKGSPVLITSIPVGGSQVTSDLAKVKNLPLETAERIKIKDGCCWIPLLEGEGSVLISSQGNRIPVEISKREIAEIIEARMCEVFTIVRDRLSTVETQSGRGIIENIILCGGGAQLTGAVELASAIFDTPRVHLGIPGTLGGLAGEYRSPEFAVVLGLILEYTHKQGQRAYQGRAEMERAGVFTKVKDIWRNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83418</accession>
    <name>O83418_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TP_0403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71329">
        <property type="entry name" value="B71329"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881851.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83418">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0403"/>
    <dbReference type="EnsemblBacteria" id="AAC65391">
        <property type="protein sequence ID" value="AAC65391"/>
        <property type="gene ID" value="TP_0403"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75597">
        <property type="protein sequence ID" value="AGN75597"/>
        <property type="gene ID" value="TPANIC_0403"/>
    </dbReference>
    <dbReference type="GeneID" id="57878929"/>
    <dbReference type="KEGG" id="tpa:TP_0403"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.403"/>
    <dbReference type="HOGENOM" id="CLU_139638_0_0_12"/>
    <dbReference type="OMA" id="KEWMKED"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAC65391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="150" mass="17540" checksum="142F5BCB0423CAB1" modified="1998-11-01" version="1">MKRFCFSLERVRRLRAFRVRELEVELSKVLAEYGSIDTQIRSIAGEYRARMQDVAPKRGAVFSAASVSAVQDQIDVLQLRREQLLHKQAHLSFTLEQLRERYAHARRAHEALLMLEEKEKTRWREQRLRAEDRACDDLVSARVPGAPSKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>O83424</accession>
    <name>Y409_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative uncharacterized protein TP_0409</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0409</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Could be the product of a pseudogene. It is encoded in the reverse strand of the region coding for TP_0409.1, a potential gene which belongs to the UPF0092 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71329">
        <property type="entry name" value="H71329"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83424"/>
    <dbReference type="IntAct" id="O83424">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65397">
        <property type="protein sequence ID" value="AAC65397"/>
        <property type="gene ID" value="TP_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0409"/>
    <dbReference type="HOGENOM" id="CLU_2921413_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="uncertain"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202249" description="Putative uncharacterized protein TP_0409">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="61" mass="7158" checksum="B820776723FAC984" modified="1998-11-01" version="1">MIDWIVFFALAWGRARVSCALKDENNAPSNSFANHYGERWLDPTARYRRRMSDLLPFCFCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>O83485</accession>
    <name>UVRC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">TP_0472</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71322">
        <property type="entry name" value="B71322"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881921.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83485"/>
    <dbReference type="SMR" id="O83485"/>
    <dbReference type="IntAct" id="O83485">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0472"/>
    <dbReference type="EnsemblBacteria" id="AAC65452">
        <property type="protein sequence ID" value="AAC65452"/>
        <property type="gene ID" value="TP_0472"/>
    </dbReference>
    <dbReference type="GeneID" id="57878993"/>
    <dbReference type="KEGG" id="tpa:TP_0472"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_12"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000138356" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="691" mass="78210" checksum="F19A2E7F78F8313D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83513</accession>
    <name>O83513_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein (Pbp-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71316">
        <property type="entry name" value="H71316"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881949.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83513"/>
    <dbReference type="IntAct" id="O83513">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0500"/>
    <dbReference type="EnsemblBacteria" id="AAC65487">
        <property type="protein sequence ID" value="AAC65487"/>
        <property type="gene ID" value="TP_0500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75690">
        <property type="protein sequence ID" value="AGN75690"/>
        <property type="gene ID" value="TPANIC_0500"/>
    </dbReference>
    <dbReference type="GeneID" id="57879021"/>
    <dbReference type="KEGG" id="tpa:TP_0500"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.496"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_12"/>
    <dbReference type="OMA" id="TLACKTG"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="59"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="265"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="624" mass="71407" checksum="832303C65251103C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83557</accession>
    <name>O83557_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic serine protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71310">
        <property type="entry name" value="F71310"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0546"/>
    <dbReference type="MEROPS" id="S01.454"/>
    <dbReference type="EnsemblBacteria" id="AAC65532">
        <property type="protein sequence ID" value="AAC65532"/>
        <property type="gene ID" value="TP_0546"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75733">
        <property type="protein sequence ID" value="AGN75733"/>
        <property type="gene ID" value="TPANIC_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0546"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.542"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026857_0_0_12"/>
    <dbReference type="OMA" id="MHRKIFI"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="666" mass="73321" checksum="8D838DAF31B9FF2A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83559</accession>
    <name>Y548_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>UPF0164 protein TP_0548</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0548</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0164 family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAC65537" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65537.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71310">
        <property type="entry name" value="H71310"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83559"/>
    <dbReference type="STRING" id="243276.TPANIC_0548"/>
    <dbReference type="EnsemblBacteria" id="AAC65537">
        <property type="protein sequence ID" value="AAC65537"/>
        <property type="gene ID" value="TP_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0548"/>
    <dbReference type="eggNOG" id="ENOG5033RFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042920_0_0_12"/>
    <dbReference type="OMA" id="KWLIPNG"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005362">
        <property type="entry name" value="UPF0164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03687">
        <property type="entry name" value="UPF0164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000036216" description="UPF0164 protein TP_0548">
        <location>
            <begin position="38"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="426" mass="45955" checksum="D46BF01CA02B1A56" modified="2001-06-01" version="2" precursor="true">MISCSVRRRPRWEPQVGAAFLAFALLPVLASGRGMQAAVATAAGSSGSGSDGKHPGKEQFLQFLIPSGGRYEYLGVSFTALADDASFFEANPAGSAGLSRGEVALFHHSQIHDSHTETVSFARRTQNTGYGASVRAFSSESDLKSFFGGNSGGNKNGGHQGKQGKGFVAIANASHTFCGQYRFKGVSFGCNFKMGFRKGKTDSHVTVAGDLGLRAAFSVAKNFGSNEPNMHVGLVLKNAGISVKTNSCQVEHLNPAIAVGFAYRPVYAFLFSLGLQQTLTKRESPVCSVGFMFFCTQHVTLLASAACEGGAYALSGGAEIRIGSFHLDMGYRYDQIFQAAHPHHVSVGLKWLIPNGGTQADQALLVKESYLVGLRFYDQRRYQEAITAWQLTLRQDPGFEPAAEGIERARRFLKLHEKLSLFDILN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83564</accession>
    <name>Y553_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative transport protein TP_0553</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0553</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71309">
        <property type="entry name" value="E71309"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882000.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83564"/>
    <dbReference type="STRING" id="243276.TPANIC_0553"/>
    <dbReference type="EnsemblBacteria" id="AAC26557">
        <property type="protein sequence ID" value="AAC26557"/>
        <property type="gene ID" value="TP_0553"/>
    </dbReference>
    <dbReference type="GeneID" id="57879079"/>
    <dbReference type="KEGG" id="tpa:TP_0553"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_3_12"/>
    <dbReference type="OMA" id="EIAYVYQ"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000148324" description="Putative transport protein TP_0553">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="403" mass="45284" checksum="5A8370CD6749115B" modified="1998-11-01" version="1">MEKQSPAQTISLFVLLALMFVLVCMLFVPYLTVLLWSSILAILLSPCYRALCARIDMHAFTRTRHLVSHMNGEDGCTAAITRATRFQKKMLAAVFSLVITLLVTTVFFFIAISLFGQGKLLFDKLSLFFREYDLFEGAKQRSFTALIFKLSRGTVDISTLNVEEHLLRFFGKHVESVFVYTQIFVKNIARAALSTLFFSFTLYFFFLDGEHLSCLLIAALPLRKRASAQLLEKCKEATRHLFKGLFSIAFYQTCVAFVFYGIFRVEGPMALAMLTFFASFLPLVGCACVWLPVGISIGFTSGWMRGTLFLFVAGSSITIIDSFLRPLLLQNKMRIHPLLIFFSMLGGVQTFGFNGMVLGPILVILLFTVIDLTHDGESHYTSIFHDPPAAGVHAQSIHRQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>O83566</accession>
    <name>O83566_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate/ aspartate transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TP_0555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71309">
        <property type="entry name" value="G71309"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882002.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83566">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0555"/>
    <dbReference type="EnsemblBacteria" id="AAC26559">
        <property type="protein sequence ID" value="AAC26559"/>
        <property type="gene ID" value="TP_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0555"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.594"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035303_0_0_12"/>
    <dbReference type="OMA" id="PVNLQLC"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAC26559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="396" mass="41915" checksum="928454E4537F416E" modified="1998-11-01" version="1">MAGSAGFWLLAKLSGGMVCGVALGLCVNESVMAIIHTGKTLIGGVVFFVIPLVIFGFIAPTVLSLKASAGRMLGSFLVLSYLSSVGASLFATAMGRVVIPYLRIPRTVEGLRTIPKVIFTLEIPSLMPVVTALAFALLVGLSALWVKARAVEQVLYEFRRMMGEAISRVLVPLLPFFVAATFAELAYSGSLTRQLPLFAKVVAVVIVGHLLWLCVLYLVGWILSRKNPFEVLRHYGAAYATALGTMSSAATLPVSLQCAHKSRALPAEIVDFAIPLGATTHLCGSVLTETFFCLTIAQMLYGSMPSLADMVLFSCLFGIFAVGAPGVPGGTVLASLGLVLDVLHFDTTGTGLLIAIFALQDSFGTACNITGDGALALMLRGLRYTLRANCVGREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83568</accession>
    <name>O83568_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC26561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71310">
        <property type="entry name" value="A71310"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882004.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83568">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0557"/>
    <dbReference type="EnsemblBacteria" id="AAC26561">
        <property type="protein sequence ID" value="AAC26561"/>
        <property type="gene ID" value="TP_0557"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75744">
        <property type="protein sequence ID" value="AGN75744"/>
        <property type="gene ID" value="TPANIC_0557"/>
    </dbReference>
    <dbReference type="GeneID" id="57879083"/>
    <dbReference type="KEGG" id="tpa:TP_0557"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.554"/>
    <dbReference type="eggNOG" id="COG3683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088941_1_0_12"/>
    <dbReference type="OMA" id="HPHMFID"/>
    <dbReference type="OrthoDB" id="1698942at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010412">
        <property type="entry name" value="DUF1007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016537">
        <property type="entry name" value="UCP008159_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06226">
        <property type="entry name" value="DUF1007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008159">
        <property type="entry name" value="UCP008159_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC26561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="237" mass="27762" checksum="D9BA83E7DFDCDB02" modified="1998-11-01" version="1">MKKRMWRAVRTLLIICAGGTGALWAHPHVFIRTKVTFQWQKGVLQRAHITWEFDPFFSADIISGYDTNKDGLFDKKETQQVFENAFIHTKHYSFFTFIRSGESHARRARSQAARTSPQSVQHFSVSQKDGTLSYHFSIDLSSYQHAKSAPPGTRRTLYLALYDHSFFCDFRYAEHDTVRFVCDKARVQPSYEIVENRTAPVYYDPFDSIESTPQYEHWRPGLHTYYPKEILLRYTAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>O83598</accession>
    <name>PTHP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphocarrier protein HPr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Histidine-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ptsH</name>
        <name type="ordered locus">TP_0589</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Phosphorylation on Ser-46 inhibits the phosphoryl transfer from enzyme I to HPr.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPr family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71305">
        <property type="entry name" value="F71305"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882035.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83598"/>
    <dbReference type="SMR" id="O83598"/>
    <dbReference type="IntAct" id="O83598">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0589"/>
    <dbReference type="EnsemblBacteria" id="AAC65564">
        <property type="protein sequence ID" value="AAC65564"/>
        <property type="gene ID" value="TP_0589"/>
    </dbReference>
    <dbReference type="GeneID" id="57879110"/>
    <dbReference type="KEGG" id="tpa:TP_0589"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_2_2_12"/>
    <dbReference type="OMA" id="SIMAMMM"/>
    <dbReference type="OrthoDB" id="404807at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0598">Phosphotransferase system</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000107887" description="Phosphocarrier protein HPr">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by HPrK/P" evidence="2">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="88" mass="9527" checksum="016FB95A2ED5C611" modified="1998-11-01" version="1">MVVKTVRVLNRAGVHARPAALIVQAASRFDSKIMLVRDTIRVNAKSIMGVMAMAAGCGSELELVVEGPDEVAALSAIERLFQNKFEEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>O83600</accession>
    <name>HPRK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>HPr kinase/phosphorylase</fullName>
            <shortName>HPrK/P</shortName>
            <ecNumber>2.7.11.-</ecNumber>
            <ecNumber>2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">hprK</name>
        <name type="synonym">ptsK</name>
        <name type="ordered locus">TP_0591</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-"/>
    <dbReference type="EC" id="2.7.4.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71305">
        <property type="entry name" value="H71305"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83600"/>
    <dbReference type="SMR" id="O83600"/>
    <dbReference type="IntAct" id="O83600">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0591"/>
    <dbReference type="EnsemblBacteria" id="AAC65566">
        <property type="protein sequence ID" value="AAC65566"/>
        <property type="gene ID" value="TP_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0591"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052030_0_1_12"/>
    <dbReference type="OMA" id="AMNNRQK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000059004" description="HPr kinase/phosphorylase">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="1">
        <location>
            <begin position="264"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="319" mass="35548" checksum="5ADF40485574B12D" modified="1998-11-01" version="1">MLKLDLKERDSLDLRCIAGHHGLANPITISDLNRPGLVLSGFFDFVAYRRIQLFGRGEHAYLLALLEQGRYGAIEKMFTFDLPCCIFSHGITPPEKFLHLAEPSSCPILVTRLTSSELSLRLMRVLSNIFAPTIALHGVLVEVYGVGILISGDSGVGKSETALELIERGHRLVADDLVEISCVNGNSLIGRGVHKSIGHHMEIRGLGIINITQLYGVGSIRERKEIQMVVQLEEWNSSKAYDRLGTQELNTTILDVSVPLIEIPVRPGRNIPIILETAAMNERLKRMGYFSAKEFNQSVLKLMEQNAAHAPYYRPDDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83624</accession>
    <name>O83624_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen fixation protein (NifU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71303">
        <property type="entry name" value="D71303"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882061.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83624">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0615"/>
    <dbReference type="EnsemblBacteria" id="AAC65591">
        <property type="protein sequence ID" value="AAC65591"/>
        <property type="gene ID" value="TP_0615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75796">
        <property type="protein sequence ID" value="AGN75796"/>
        <property type="gene ID" value="TPANIC_0615"/>
    </dbReference>
    <dbReference type="GeneID" id="57879138"/>
    <dbReference type="KEGG" id="tpa:TP_0615"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.607"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_12"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="147" mass="16213" checksum="AFF1E4EA8AEEA241" modified="1998-11-01" version="1">MNAEAIYRQVLLEYARKQEHRRVLEGPVGIERGHNPSCGDDLTLLIKREGDRIADVAFLGTGCAVSTASTNILIELIKGASVAQAQKTVALFFHMMAQQCLTDQERAHLQDACILACFASMPARIKCATLSWHNADILLHHKKDTDA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83625</accession>
    <name>RPIA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoriboisomerase A</fullName>
            <shortName evidence="1">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpiA</name>
        <name type="ordered locus">TP_0616</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71303">
        <property type="entry name" value="E71303"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882062.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83625"/>
    <dbReference type="SMR" id="O83625"/>
    <dbReference type="STRING" id="243276.TPANIC_0616"/>
    <dbReference type="EnsemblBacteria" id="AAC65592">
        <property type="protein sequence ID" value="AAC65592"/>
        <property type="gene ID" value="TP_0616"/>
    </dbReference>
    <dbReference type="GeneID" id="57879139"/>
    <dbReference type="KEGG" id="tpa:TP_0616"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_12"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="1681738at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158489" description="Ribose-5-phosphate isomerase A">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <sequence length="254" mass="27573" checksum="028FACD2FC5F3751" modified="1998-11-01" version="1">MHERNTTTNTPLDVTAQKLLVAQRSVDTLVQEGVLHAHMSIGLGTGSTAMPAVKRIADHLARGTLSDIAAVPTSFQTALICERYNIPLFSLSSKRIGGKLDVTIDGADEIDTQNFVIKGGGAALLQEKIAAYNSAHFVIIVDETKVVETLGTRAALPIEVVPEARMSVMRTLQDWGLSVHIREAVRKKGPVVTDHGNFILDARWQSLPTRTPQDMERALNALPGVIENGLFTERTVRVFVAHADGSVEERSASF</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83634</accession>
    <name>O83634_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sbcD</name>
        <name evidence="8" type="ordered locus">TP_0626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1198617">
            <id>O83634</id>
        </interactant>
        <interactant intactId="EBI-1589991">
            <id>O83213</id>
            <label>TP_0183</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71302">
        <property type="entry name" value="C71302"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882072.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83634">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0626"/>
    <dbReference type="EnsemblBacteria" id="AAC65598">
        <property type="protein sequence ID" value="AAC65598"/>
        <property type="gene ID" value="TP_0626"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75807">
        <property type="protein sequence ID" value="AGN75807"/>
        <property type="gene ID" value="TPANIC_0626"/>
    </dbReference>
    <dbReference type="GeneID" id="57879149"/>
    <dbReference type="KEGG" id="tpa:TP_0626"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.618"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038045_0_1_12"/>
    <dbReference type="OMA" id="TSGNHDS"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="7">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44298" checksum="7E6369124A3CEC85" modified="1998-11-01" version="1">MKILHTADLHLGKTLHEVSLFASQKKMLGDLCTLLAQDNYAALIIAGDIYDRCVPSAESVSLFSSFLQNIKRSMPRLPIYLIPGNHDSAQRLSFAQELLKQQGVFIAQDPEESTRPHLLCHEGETVQLFLLPFLHAGAFSYLDEENTTCLIHTQSELLQEASRRLQRAVSLDTPSILVAHLFTQKGISCESERPFVGNAVYADPHWFDFFTYVALGHLHKCQKITERMYYSGSPLPYSFDEANTQKVALSVEIHCNTKGFPIHVTPLPLEPLIPLRTIRDSFHALYTGDRYLLYQRDFLEITLTDPALVHNPIGLLKPRYPGLLSIKQENAFAFDIPPPYSSNEGIAPCTHHSLRTHFDVFMHEVSPTPDDREKGALFQELFDEMQQEFSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-05-25" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83650</accession>
    <name>SYK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Lysine--tRNA ligase</fullName>
            <ecNumber>6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lysyl-tRNA synthetase</fullName>
            <shortName>LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">lysS</name>
        <name type="ordered locus">TP_0644</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71299">
        <property type="entry name" value="C71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882089.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83650"/>
    <dbReference type="SMR" id="O83650"/>
    <dbReference type="IntAct" id="O83650">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0644"/>
    <dbReference type="EnsemblBacteria" id="AAC65618">
        <property type="protein sequence ID" value="AAC65618"/>
        <property type="gene ID" value="TP_0644"/>
    </dbReference>
    <dbReference type="GeneID" id="57879169"/>
    <dbReference type="KEGG" id="tpa:TP_0644"/>
    <dbReference type="eggNOG" id="COG1384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_12"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="OrthoDB" id="256927at2"/>
    <dbReference type="BRENDA" id="6.1.1.6">
        <property type="organism ID" value="6429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152745" description="Lysine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="36"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="528" mass="60901" checksum="B90425263C4EBF6D" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83654</accession>
    <name>O83654_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71299">
        <property type="entry name" value="G71299"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882093.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83654">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0648"/>
    <dbReference type="EnsemblBacteria" id="AAC65621">
        <property type="protein sequence ID" value="AAC65621"/>
        <property type="gene ID" value="TP_0648"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75828">
        <property type="protein sequence ID" value="AGN75828"/>
        <property type="gene ID" value="TPANIC_0648"/>
    </dbReference>
    <dbReference type="GeneID" id="57879172"/>
    <dbReference type="KEGG" id="tpa:TP_0648"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.641"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412143_0_0_12"/>
    <dbReference type="OMA" id="ICYSSNE"/>
    <dbReference type="OrthoDB" id="373006at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="682" mass="77635" checksum="9C6F0E424EFDFEBC" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>O83658</accession>
    <name>POTA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="1">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">potA</name>
        <name type="ordered locus">TP_0652</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + polyamine-[polyamine-binding protein]Side 1 = ADP + phosphate + polyamineSide 2 + [polyamine-binding protein]Side 1.</text>
            <dbReference type="EC" id="7.6.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71296">
        <property type="entry name" value="E71296"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83658"/>
    <dbReference type="SMR" id="O83658"/>
    <dbReference type="STRING" id="243276.TPANIC_0652"/>
    <dbReference type="EnsemblBacteria" id="AAC65627">
        <property type="protein sequence ID" value="AAC65627"/>
        <property type="gene ID" value="TP_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0652"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_12"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51305">
        <property type="entry name" value="POTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000286320" description="Spermidine/putrescine import ATP-binding protein PotA">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01726"/>
        </source>
    </evidence>
    <sequence length="379" mass="42323" checksum="37835B6BCABFD6F2" modified="1998-11-01" version="1">MRQTVKGCAVTIDQVSKAYGHCLAVDRATVHIRQGEFFSILGPSGCGKTTLLRIIAGFEQPDSGDLTFDHVSVLGVGANKRRSNTVFQSYALFPHLSVYENIAFPLRLKRLSKNLIRERVHEYLHLVQLDEHLHKKPHQLSGGQQQRVAIARALVCEPGVLLLDEPLSALDAKLRSNLLIELDTLHDQTGITFVFITHDQSEALSVSDRIAVMNKGKILQIGTPYEIYEQPATDFVAKFIGETNSFLSTVVSCTAIENEEFMLSLQVPELDRTLTVTADNPIDPGRRVCFTVRPEKIHISLEEPGTTSAPLNVFRGFVEEPVYAGFQSKFFVQLESGAIIQVFQQHQKYLDTGPEIAWKDTVYVSWSAHDGYVVEDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83670</accession>
    <name>O83670_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar filament outer layer protein (FlaA-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71298">
        <property type="entry name" value="A71298"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882109.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83670">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0664"/>
    <dbReference type="EnsemblBacteria" id="AAC65637">
        <property type="protein sequence ID" value="AAC65637"/>
        <property type="gene ID" value="TP_0664"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75842">
        <property type="protein sequence ID" value="AGN75842"/>
        <property type="gene ID" value="TPANIC_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0664"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.656"/>
    <dbReference type="eggNOG" id="ENOG5033RD4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097187_0_0_12"/>
    <dbReference type="OMA" id="FEFANTW"/>
    <dbReference type="OrthoDB" id="820844at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006714">
        <property type="entry name" value="FlaA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04620">
        <property type="entry name" value="FlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014102078" evidence="3">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26821" checksum="9EDDF816CAC61B89" modified="1998-11-01" version="1">MKKIAVVSVGVLVFSAHAQEAAGSRDVADPSRIGMYAAAQRLKEVSVDKFENEGTWVVSMSSDEGTIKGRLFEGGPARKRPIPEEGDMKIPDSKVFGAKVSFYRRGYNSFEVSSVKPLPVEGVAKTVSVWVAGRGYPHSLSLLLEDFWGQRFELHMGQLDFSGWKLMSVAIPPQHVDGKTGIVQKSRRFPNQSGLNIVGFRVDCDPLEAYGNYYVYFDDLRVVTDLYDVESREPDDMSDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>O83673</accession>
    <name>O83673_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine kinase (Udk)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71298">
        <property type="entry name" value="D71298"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0667"/>
    <dbReference type="EnsemblBacteria" id="AAC65638">
        <property type="protein sequence ID" value="AAC65638"/>
        <property type="gene ID" value="TP_0667"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75845">
        <property type="protein sequence ID" value="AGN75845"/>
        <property type="gene ID" value="TPANIC_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0667"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.659"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023775_1_0_12"/>
    <dbReference type="OMA" id="EREHIFP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="287"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="555" mass="63001" checksum="2DCC799AE3F38C4C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83692</accession>
    <name>O83692_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5,10-methenyltetrahydrofolate synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71293">
        <property type="entry name" value="C71293"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882139.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83692">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0694"/>
    <dbReference type="EnsemblBacteria" id="AAC65661">
        <property type="protein sequence ID" value="AAC65661"/>
        <property type="gene ID" value="TP_0694"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75872">
        <property type="protein sequence ID" value="AGN75872"/>
        <property type="gene ID" value="TPANIC_0694"/>
    </dbReference>
    <dbReference type="GeneID" id="57879220"/>
    <dbReference type="KEGG" id="tpa:TP_0694"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.686"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_1_1_12"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="153"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="225" mass="24408" checksum="6E11346C79E1EF47" modified="1998-11-01" version="1">MNAKQNARRIASARLRAFRASPTAPAYPAHSLFTAQTAYQRARTVFFYAPLPLEIDPYALAYTAENAGKHVALPRVSGNDLHFHAVTYACTTRPSVSCFTTLCPRTRGIREPDAHSPRLYPPHPSPNTPAQRTLALPLLIVVPALAFSTNGARLGRGGGHYDRFLARIAATIPAGSYYTLGLCFDCQIMAVIPQEAHDQSVHAVLTETRLISCATARAPAPPFSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>O83698</accession>
    <name>Y700_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0700</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0700</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71294">
        <property type="entry name" value="A71294"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882145.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83698"/>
    <dbReference type="IntAct" id="O83698">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0700"/>
    <dbReference type="EnsemblBacteria" id="AAC65669">
        <property type="protein sequence ID" value="AAC65669"/>
        <property type="gene ID" value="TP_0700"/>
    </dbReference>
    <dbReference type="GeneID" id="57879225"/>
    <dbReference type="KEGG" id="tpa:TP_0700"/>
    <dbReference type="HOGENOM" id="CLU_154673_0_0_12"/>
    <dbReference type="OMA" id="MIQTENI"/>
    <dbReference type="OrthoDB" id="2034118at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202306" description="Uncharacterized protein TP_0700">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <sequence length="130" mass="14204" checksum="09892AFCE31E4868" modified="1998-11-01" version="1">MVMAAAPLQNLCYDGLLQVTSGGNISLPVPSNQVIYAHFEHVDATPAEQGQAGVSVSELQILDALVERLIVQRRVAAEAADMAVQKRQETLLRAAELFSQKQVDETKRRGESLPYTSVEVQGPELFDLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83712</accession>
    <name>O83712_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71287">
        <property type="entry name" value="G71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882175.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83712">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0730"/>
    <dbReference type="EnsemblBacteria" id="AAC65698">
        <property type="protein sequence ID" value="AAC65698"/>
        <property type="gene ID" value="TP_0730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75904">
        <property type="protein sequence ID" value="AGN75904"/>
        <property type="gene ID" value="TPANIC_0730"/>
    </dbReference>
    <dbReference type="GeneID" id="57879254"/>
    <dbReference type="KEGG" id="tpa:TP_0730"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.719"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064741_0_0_12"/>
    <dbReference type="OMA" id="KAPAHRF"/>
    <dbReference type="OrthoDB" id="1411517at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="365" mass="39799" checksum="90463CE2CFB0D24B" modified="1998-11-01" version="1">MARASSPLSSMHSPHSLPFSAHCAARLRKKTCQSGSDASFQYKAHEKFSTLPKAPARRFFPVQYFPVSPDKRWILGYFSPPSMEKETAGILCSYTLFHSALVLALSLAHGRTQVPPSSTLSFLTVIVLWHCLLFFFLVAYSREPADTTVPFKPLPEQTAPICAAASSDCKENRTALKTLNTATHITLIRASAIPIVGFLLKFHALAGLSYFLVAGLSVLFLTDFIDGKIARARRETSRVGETLDAASDYALIGLISALYYQSGVVPLWFFVLIITRLSLQTVIACVYALFGHPMTGSTAGGKATVAVTMLLYTLELARLLLPNLARSNSGARFFTGAEILAGFVIFTGIVEKLYLGVQHRPGRSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83728</accession>
    <name>PPDK_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="3">2.7.9.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pyruvate, orthophosphate dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ppdK</name>
        <name type="ordered locus">TP_0746</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of pyruvate and phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activated by light-induced dephosphorylation. Inhibited by dark-induced phosphorylation. Both reactions are catalyzed by PDRP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain contains the ATP/Pi active site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate active site.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation of Ser-440 in the dark inactivates the enzyme. Dephosphorylation upon light stimulation reactivates the enzyme.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The reaction takes place in three steps, each mediated by a carrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71286">
        <property type="entry name" value="G71286"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882191.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83728"/>
    <dbReference type="SMR" id="O83728"/>
    <dbReference type="STRING" id="243276.TPANIC_0746"/>
    <dbReference type="EnsemblBacteria" id="AAC65714">
        <property type="protein sequence ID" value="AAC65714"/>
        <property type="gene ID" value="TP_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0746"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_12"/>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000147050" description="Pyruvate, phosphate dikinase">
        <location>
            <begin position="1"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal">
        <location>
            <begin position="1"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker 1">
        <location>
            <begin position="322"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Central">
        <location>
            <begin position="381"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker 2">
        <location>
            <begin position="483"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal">
        <location>
            <begin position="523"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by PDRP1" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P22983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="901" mass="100298" checksum="E9463FE160781ACE" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83731</accession>
    <name>Y750_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0750</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0750</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71287">
        <property type="entry name" value="C71287"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882195.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83731"/>
    <dbReference type="SMR" id="O83731"/>
    <dbReference type="STRING" id="243276.TPANIC_0750"/>
    <dbReference type="EnsemblBacteria" id="AAC65716">
        <property type="protein sequence ID" value="AAC65716"/>
        <property type="gene ID" value="TP_0750"/>
    </dbReference>
    <dbReference type="GeneID" id="57879273"/>
    <dbReference type="KEGG" id="tpa:TP_0750"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255493_0_0_12"/>
    <dbReference type="OMA" id="HLISIEI"/>
    <dbReference type="OrthoDB" id="1387470at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014256" description="Uncharacterized protein TP_0750">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="223" mass="25940" checksum="3CE1E08E88FE65BD" modified="1998-11-01" version="1" precursor="true">MHLKKALCPALCTFLIHLCLHAGERTVPVDIFLMIDKSRSMQEPGKFSSLHRWVRDEFVSSMTIQGDWITVYQFYEKPEELITLTLRSEQDRDKIISVVDSIVPNGRYTDIGRALDTVWEIQEKRKDNNRHKVLLLVTDLEHDAPLTSKYRGKQRSFQSPYLVRARRVKHDNWYEITLDMAVHDRVAHTARELYRSIAAAHSKRPTPTPPAKESSPRYTPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83749</accession>
    <name>O83749_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TP_0770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71283">
        <property type="entry name" value="G71283"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882215.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0770"/>
    <dbReference type="EnsemblBacteria" id="AAC65738">
        <property type="protein sequence ID" value="AAC65738"/>
        <property type="gene ID" value="TP_0770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75943">
        <property type="protein sequence ID" value="AGN75943"/>
        <property type="gene ID" value="TPANIC_0770"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243276.5.peg.813"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
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    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
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        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
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        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="78"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="272"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="595"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="649" mass="72496" checksum="7F2E4A37066D36BD" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>O83778</accession>
    <name>O83778_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine-type D-Ala-D-Ala carboxypeptidase (DacC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TP_0800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="B71279"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="TP_0800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75972">
        <property type="protein sequence ID" value="AGN75972"/>
        <property type="gene ID" value="TPANIC_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0800"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.786"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_8_1_12"/>
    <dbReference type="OMA" id="MANDFLA"/>
    <dbReference type="OrthoDB" id="1499212at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="92"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAC65769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="490" mass="52810" checksum="7289A98AFCED4CF3" modified="1998-11-01" version="1">MPGHPVHACTARLKDHSSRSLRAVARRRGQRALYALGACVVGAGALQWHAQRVLHPSFLFSPTLRFSPSSRNPFSAHPIRTLQFTNLSAGSTPPPISARAYAIAEGGSGTLLASFCADLPLPPASLAKLVTCAVVMEALERGELHWQQRIRVPLAGSAQAFAPGSSLIFLRTGEYISVHDLLAGMNIASGNDAAYTLAYAVAGSIPAFCTRMNTLVQKWGLTRTRFVEPSGLSEHNVTTARDFVLFCCQYVRRWPENLARFHARSYFQRSNSPATSRIPPHTRFPATNTLLAATAARGNVSTAVPGCDGLKTGYIRESGFNVALSSLRGDTRIIAVILGGAGNSIPEGKRIRARDGATLLYWAFTHFQCTDVRTAISDALPCAIPVLGSKRPGALRPILHPSCTSCPVLNTPGTRISITFALPPLLRAPLQETDVIGFAHVLDESNGMVLARVPLVSGTTLTAGGNARRIIDEVAVWSVELWRKIREKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>O83781</accession>
    <name>O83781_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71279">
        <property type="entry name" value="E71279"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882248.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83781">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0803"/>
    <dbReference type="EnsemblBacteria" id="AAC65775">
        <property type="protein sequence ID" value="AAC65775"/>
        <property type="gene ID" value="TP_0803"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75975">
        <property type="protein sequence ID" value="AGN75975"/>
        <property type="gene ID" value="TPANIC_0803"/>
    </dbReference>
    <dbReference type="GeneID" id="57879321"/>
    <dbReference type="KEGG" id="tpa:TP_0803"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.789"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700087_0_0_12"/>
    <dbReference type="OMA" id="EMASHIH"/>
    <dbReference type="OrthoDB" id="869989at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="41"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="402" mass="44578" checksum="33E27AC7D9B5EE28" modified="1998-11-01" version="1">MGALACDYTYSPSPKRDLSIAAKNAVVRNILQEIAIHGSFLLLGHEHPDEDCIASLVAFALLLTRCNKRVEICCQGPIRVQISFLIDICLYNGIAVHLDTQTVPRMPDALVILDTPNPGMIYAPPSCRLLLSDSTIRKIELDHHLFANAACCGDPGYSLIARASSTCEIIAYLCYKLARNHAQRTALGIRNLYSRNVVLSILTGMIGDAKTGAYLISRKDRALYTYFTQRLNTMLREKTKPITGNIASTKQILHTLESLSAEEHAVYQTMVKNVQHRGSISLLLLNQTQTQALHECCNAEHFVSLIKMATSNIAESISGIGISAYPDPTQQFYVTQWRVRTAARVKQLDLRLLLSHFAIQNGGGHAGAIGFRFFAHELINQDLFTEALVAYLDDRLHHMQSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>O83787</accession>
    <name>RNC_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">TP_0809</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71277">
        <property type="entry name" value="G71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882254.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83787"/>
    <dbReference type="SMR" id="O83787"/>
    <dbReference type="IntAct" id="O83787">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0809"/>
    <dbReference type="EnsemblBacteria" id="AAC65778">
        <property type="protein sequence ID" value="AAC65778"/>
        <property type="gene ID" value="TP_0809"/>
    </dbReference>
    <dbReference type="GeneID" id="57879327"/>
    <dbReference type="KEGG" id="tpa:TP_0809"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_12"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000180450" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="181"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <sequence length="254" mass="28341" checksum="4A4805595B714F89" modified="1998-11-01" version="1">MSLCLGHIFSRSRSPLTPERRESLRRLQETLGVKFRDPTALDQALSHRSLFSSKEDHCGVRHNERMEFLGDAVLGAVAAACLYRALPDSHEGDLAKTKAVLVSTDTLSDIALSLRIDHYLLLGKGEELSGGRHKKAILADATEAVIGALFLDSGFKAAERFVLRLLLPRVRPIREKNLHHDYKSTLQVLAHQRYRSKPEYTVVKRTGPDHSVRFWVDVTVGDARFGPGYGTSKKSAEQCAARLAWEQLSGTLRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>O83790</accession>
    <name>TRXB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Thioredoxin reductase</fullName>
            <shortName>TRXR</shortName>
            <ecNumber>1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">trxB</name>
        <name type="ordered locus">TP_0814</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71278">
        <property type="entry name" value="C71278"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882258.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83790"/>
    <dbReference type="SMR" id="O83790"/>
    <dbReference type="IntAct" id="O83790">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0814"/>
    <dbReference type="EnsemblBacteria" id="AAC65780">
        <property type="protein sequence ID" value="AAC65780"/>
        <property type="gene ID" value="TP_0814"/>
    </dbReference>
    <dbReference type="GeneID" id="57879332"/>
    <dbReference type="KEGG" id="tpa:TP_0814"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_12"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000166754" description="Thioredoxin reductase">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P0A9P4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="307" mass="32868" checksum="2519A5BA3BB4E012" modified="1998-11-01" version="1">METDYDVIIVGAGAAGLSAAQYACRANLRTLVIESKAHGGQALLIDSLENYPGYATPISGFEYAENMKKQAVAFGAQIAYEEVTTIGKRDSVFHITTGTGAYTAMSVILATGAEHRKMGIPGESEFLGRGVSYCATCDGPFFRNKHVVVIGGGDAACDESLVLSRLTDRVTMIHRRDTLRAQKAIAERTLKNPHIAVQWNTTLEAVRGETKVSSVLLKDVKTGETRELACDAVFFFIGMVPITGLLPDAEKDSTGYIVTDDEMRTSVEGIFAAGDVRAKSFRQVITATSDGALAAHAAASYIDTLQN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83793</accession>
    <name>Y818_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0818</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0818</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71278">
        <property type="entry name" value="G71278"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83793"/>
    <dbReference type="IntAct" id="O83793">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0818"/>
    <dbReference type="EnsemblBacteria" id="AAC65788">
        <property type="protein sequence ID" value="AAC65788"/>
        <property type="gene ID" value="TP_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0818"/>
    <dbReference type="HOGENOM" id="CLU_3123856_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202334" description="Uncharacterized protein TP_0818">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <sequence length="50" mass="5572" checksum="9ACF6C687553C5AC" modified="1998-11-01" version="1">MEYRGGWYSYFLCGVLSGKGARRAGAIERVENLYAFFFACYHAPTSGGLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O83802</accession>
    <name>TRUA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="synonym">hisT</name>
        <name type="ordered locus">TP_0830</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71276">
        <property type="entry name" value="H71276"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882274.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83802"/>
    <dbReference type="SMR" id="O83802"/>
    <dbReference type="IntAct" id="O83802">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0830"/>
    <dbReference type="EnsemblBacteria" id="AAC65796">
        <property type="protein sequence ID" value="AAC65796"/>
        <property type="gene ID" value="TP_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0830"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_12"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000057479" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="280" mass="32002" checksum="23D93A7661FCA24E" modified="1998-11-01" version="1">MNDVRKILLRISYDGTRFCGWQKQVSGSRERAPSVQGELEKVAEKIHHQKIAVIGSGRTDSGVHAVGQAAHFCTPMRNILAYRFIPAFNSLLPHSIRITDAREVSSQLHARFSAVMRTYRYHLHCAPVAYAHELPYCWHIARMPDIHLLNQYAATLKGELDCTSFAAAGDKSASKSRYFYDTHFSFNHRVLTFEISANAFLWKMVRSLTGTLLHCEKKRCSVREFVRILHAKDRRLQGPPHRRMGYSYGTSVTPNTYSVQNRNTLARELASTGNARWKTY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>O83803</accession>
    <name>SYR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Arginine--tRNA ligase</fullName>
            <ecNumber>6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginyl-tRNA synthetase</fullName>
            <shortName>ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">argS</name>
        <name type="ordered locus">TP_0831</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71277">
        <property type="entry name" value="A71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882275.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83803"/>
    <dbReference type="SMR" id="O83803"/>
    <dbReference type="IntAct" id="O83803">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0831"/>
    <dbReference type="EnsemblBacteria" id="AAC65797">
        <property type="protein sequence ID" value="AAC65797"/>
        <property type="gene ID" value="TP_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0831"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_12"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000151630" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="589" mass="67132" checksum="FA6156A69F4568E3" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>O83805</accession>
    <name>Y833_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0833</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0833</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71277">
        <property type="entry name" value="C71277"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882277.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83805"/>
    <dbReference type="IntAct" id="O83805">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0833"/>
    <dbReference type="EnsemblBacteria" id="AAC65802">
        <property type="protein sequence ID" value="AAC65802"/>
        <property type="gene ID" value="TP_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0833"/>
    <dbReference type="eggNOG" id="ENOG503004Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155974_0_0_12"/>
    <dbReference type="OMA" id="GAHYTES"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014263" description="Uncharacterized protein TP_0833">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="240" mass="26581" checksum="ECDE9943F572AED1" modified="1998-11-01" version="1" precursor="true">MRMAFMLLALLFSFRNASIQAEDARLLQPKTNALDLVVQGVDLVLFAQDKTAISISTPPEKDVFFTEHEGVLRVRTRTENAEGTRRVIRIGIPRAQTLAWVKIIATGAHTTVRGVRAVWSLLLCNEGTLALTESTLKSCTLTHTRGELRFEAAVLKRASFCLNDVNARFTLLGSRADYRLICSPGERAWKIEGAEQRGAHYTEPARARRHMVISASASSIDVMFKAPPTQQEAVDTTQKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="132" xmlns="http://uniprot.org/uniprot">
    <accession>O83809</accession>
    <name>SYT_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">TP_0837</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71275">
        <property type="entry name" value="B71275"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83809"/>
    <dbReference type="SMR" id="O83809"/>
    <dbReference type="STRING" id="243276.TPANIC_0837"/>
    <dbReference type="EnsemblBacteria" id="AAC65804">
        <property type="protein sequence ID" value="AAC65804"/>
        <property type="gene ID" value="TP_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0837"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_12"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000101078" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="193"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <sequence length="592" mass="67399" checksum="481A3461F5EF8884" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83822</accession>
    <name>IF3_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infC</name>
        <name type="ordered locus">TP_0850</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71274">
        <property type="entry name" value="B71274"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83822"/>
    <dbReference type="SMR" id="O83822"/>
    <dbReference type="IntAct" id="O83822">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0850"/>
    <dbReference type="EnsemblBacteria" id="AAC65816">
        <property type="protein sequence ID" value="AAC65816"/>
        <property type="gene ID" value="TP_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0850"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_12"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000177600" description="Translation initiation factor IF-3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <sequence length="179" mass="20359" checksum="401F311186463856" modified="1998-11-01" version="1">MYWGGSLADNKSLRINGSIRVREVRLVDAVGQQCGVVPTPEALRMARDINLDLVEVAPQASPPVCKILDYGKYRFEMGKKLRDSKKRQRLQTLKEVRMQPKINDHDMAFKAKHIQRFLDEGDKVKVTIRFRGRELAHTDLGFNVLQNVLGRLVCGYSVEKQAAMEGRSMSMTLTPKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83844</accession>
    <name>O83844_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71270">
        <property type="entry name" value="H71270"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882317.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83844">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0874"/>
    <dbReference type="EnsemblBacteria" id="AAC65837">
        <property type="protein sequence ID" value="AAC65837"/>
        <property type="gene ID" value="TP_0874"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76043">
        <property type="protein sequence ID" value="AGN76043"/>
        <property type="gene ID" value="TPANIC_0874"/>
    </dbReference>
    <dbReference type="GeneID" id="57879388"/>
    <dbReference type="KEGG" id="tpa:TP_0874"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.858"/>
    <dbReference type="eggNOG" id="ENOG5031EHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170137_1_0_12"/>
    <dbReference type="OMA" id="HIYYRRV"/>
    <dbReference type="OrthoDB" id="1991781at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10568" checksum="9A6EA2F5E738ACB2" modified="1998-11-01" version="1">MKFDGLIRNLDHITRKDTYLYYREEFSAVACYSLFGRIHSGRVEFSVETTPVGEKSVQVKLVDAIDYPLLPLVQALKRVVRLLIEKNQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83847</accession>
    <name>O83847_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71271">
        <property type="entry name" value="C71271"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882320.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83847">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0877"/>
    <dbReference type="EnsemblBacteria" id="AAC65840">
        <property type="protein sequence ID" value="AAC65840"/>
        <property type="gene ID" value="TP_0877"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76046">
        <property type="protein sequence ID" value="AGN76046"/>
        <property type="gene ID" value="TPANIC_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0877"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.929"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_12"/>
    <dbReference type="OMA" id="FLASMHD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="164"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="365" mass="41845" checksum="546626F13E51AECB" modified="1998-11-01" version="1">MGNSDICSDINDIEELQSEEGDAPIRENANPIREDYNFIREQNPILGSGLDLIGSAKLPMLFLDSNLLIEYISAEANSLFRGYYHLERKPFFNVFGNILSRKELEDFFSCVRSHSKGFTWRGTMAHKIRAKRALYTRTSFIPLSISDAQPSGYIVLFEDISDMYSQQISNMLSSLLQASKLKDNETGLHCERVNHYCRLIAEYLYDINLYPQVDTDFVENIAFLAAMHDVGKIGIPDYVLKKRGGLNELEWELMKEHTINGALILSSYPDPMAKEIALSHHERWDGTGYPFKLEGEMIPLSARITSIADVYDALRMERSYKKGFSHEQTTHMILEQSGQSFDPILARVFQKIHTKFNDVWDTLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="144" xmlns="http://uniprot.org/uniprot">
    <accession>O83862</accession>
    <name>O83862_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ordered locus">TP_0892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-1585751">
            <id>O83862</id>
        </interactant>
        <interactant intactId="EBI-1585740">
            <id>O83538</id>
            <label>TP_0526</label>
        </interactant>
        <organismsDiffer>false</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71266">
        <property type="entry name" value="A71266"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882335.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83862">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0892"/>
    <dbReference type="EnsemblBacteria" id="AAC65849">
        <property type="protein sequence ID" value="AAC65849"/>
        <property type="gene ID" value="TP_0892"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76061">
        <property type="protein sequence ID" value="AGN76061"/>
        <property type="gene ID" value="TPANIC_0892"/>
    </dbReference>
    <dbReference type="GeneID" id="57879406"/>
    <dbReference type="KEGG" id="tpa:TP_0892"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.876"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_1_12"/>
    <dbReference type="OMA" id="RRDQLPN"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAC65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="485" mass="54677" checksum="F69F7AEC06560718" modified="1998-11-01" version="1">MFGVSNDDIRKYAQEKGLDEDFAFKIVEQTLKAAYKTTFKTDENAVVTFGEERVCIYARKRVVEEVYDRVSEVDLSTALELDPTTSLDSEVLVELESEDFKRGSVQAAVQRITELSREIQKDALYAEYKSKEGEIIVGYYQRARNEHIYVDLGKVEGLMPKSHQLPQDDYRQNDRIKSLVREVRKHPKSSVVQLILSRTDSAFVKELLAVEVPEIYDGIVEVAKIVREPGYRTKIAVTSRRDDVDPVGACVGPRGIRIRMVIKELNDEKIDVLEYSPDPVIFIKNALSPAEVLNVVVLDEEKRSALAIVAESQLSIAIGKQGLNVRLANRLVDWNIDVKTESQFEEMDVYTDTRRAAENLFDNDYQEESEFSSYVGFTPELIKILQDNGIQDVQTLVDLGEEGLRALEGMDEAHVQELLAAIEENFEVVEEGEEASVTSSPGTGGDEDQALQCPECGVRITTDMSECPHCGIGLSFEFEYEENEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>O83880</accession>
    <name>Y910_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0910</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0910</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71268">
        <property type="entry name" value="C71268"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882353.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83880"/>
    <dbReference type="SMR" id="O83880"/>
    <dbReference type="STRING" id="243276.TPANIC_0910"/>
    <dbReference type="EnsemblBacteria" id="AAC65870">
        <property type="protein sequence ID" value="AAC65870"/>
        <property type="gene ID" value="TP_0910"/>
    </dbReference>
    <dbReference type="GeneID" id="57879420"/>
    <dbReference type="KEGG" id="tpa:TP_0910"/>
    <dbReference type="eggNOG" id="ENOG5031CIN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943144_0_0_12"/>
    <dbReference type="OMA" id="HWIILPF"/>
    <dbReference type="OrthoDB" id="790092at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202349" description="Uncharacterized protein TP_0910">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <sequence length="306" mass="33814" checksum="BC80543B5FAB29D8" modified="1998-11-01" version="1">MNGAVRVVLTEVPRTVSLTEGALVCVRILSSTHAGRALVAINGERVRARVPQPMHKGAVLFLRASIRAGTVFLHPQCTSTPPSAEDMSAHFLQRWGVSFSPEAAALIHAHTSLCVPLQPQLIERFALLLKKFPEQKRAHAAFLASILGDRNIPVDAAMLRRMLSTFLGESGAYTDSDTERDLFALVNHTYHSALHWLLVPFERRGAHTVWRGTLSLLLHLHKKTCTQLRVRACNTAGEWVFCVQNNVLTVQRHAARELSRTAQKKTVARLCALLRERGIDFLSVRYGAHADSANDAVPFKGIDVSV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>O83897</accession>
    <name>Y927_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0927</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0927</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71263">
        <property type="entry name" value="H71263"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83897"/>
    <dbReference type="STRING" id="243276.TPANIC_0927"/>
    <dbReference type="EnsemblBacteria" id="AAC65886">
        <property type="protein sequence ID" value="AAC65886"/>
        <property type="gene ID" value="TP_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0927"/>
    <dbReference type="eggNOG" id="ENOG5031GYP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389675_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202353" description="Uncharacterized protein TP_0927">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="196" mass="22215" checksum="F516254D0B8532E4" modified="1998-11-01" version="1">MCIQCIYARRQKRQHAGAPLAHTLRRTAHTRMPLLQEQQAAQERSVAVPGTEGKKAQNLRQLPAARLTYPTSSSTRPSHARETLYPVSGRQDSAFSFSRNTVQANTQKHKISYRNTTVCRDRDGGFMQQYSIKSDPGETSHCSIVSQTEDGYIIRICRDRDGYKKVHEVHIHQSLFDLCRRTGFITAVRQNTDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>O83901</accession>
    <name>O83901_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71264">
        <property type="entry name" value="D71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882374.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0931"/>
    <dbReference type="CAZy" id="GH63">
        <property type="family name" value="Glycoside Hydrolase Family 63"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65884">
        <property type="protein sequence ID" value="AAC65884"/>
        <property type="gene ID" value="TP_0931"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76097">
        <property type="protein sequence ID" value="AGN76097"/>
        <property type="gene ID" value="TPANIC_0931"/>
    </dbReference>
    <dbReference type="GeneID" id="57879442"/>
    <dbReference type="KEGG" id="tpa:TP_0931"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.914"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025779_0_0_12"/>
    <dbReference type="OMA" id="INSLMWD"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="476" mass="55390" checksum="3EA8559D058AEF67" modified="1998-11-01" version="1">MNKRDFPRIHFYDQDFVDIYDRTWAWIKEYWLSASGEKNTSESFFVFPEKDGLIISQHEIIFASFFFVYSNRNYDITQCLDFFYAMQEESGAIRWKYHLASKEPVLPRANPEGIGMPLFAWAEFNLFHKTANKKRIKEIMPVMVRYMKWIETQFRRSNGLYRVPLAATEMGNSPRKKAAYLVDFNSALAVSAFYLSALGDIINDKELSFQYKRVYFTLKTRINNFMWNASTGFYHDLDASGQQLPHKTIAGFWPMLGEIPNEDKAERLAEHLVNPHTFGLDHPIPSLSADEAEFDERGMGYRGSVFPPLNFVVIKGLERYQRWDLARECSIRHLYYVLDALQLNDQTKRGVLWEAYLPTREGPAQWPGKEGFPRRQYLAYAALSTITLMIENVIGLSISLPRKTVHWIIPNLEVMGIENLSLKRNLITILSSKSVRGWEVYMESEKLYYFTLNILGQKKKTLPIPSGKCSMLVDKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83903</accession>
    <name>MURE_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
            <ecNumber evidence="1">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murE</name>
        <name type="ordered locus">TP_0933</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71264">
        <property type="entry name" value="F71264"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882376.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83903"/>
    <dbReference type="SMR" id="O83903"/>
    <dbReference type="IntAct" id="O83903">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0933"/>
    <dbReference type="EnsemblBacteria" id="AAC65885">
        <property type="protein sequence ID" value="AAC65885"/>
        <property type="gene ID" value="TP_0933"/>
    </dbReference>
    <dbReference type="GeneID" id="57879443"/>
    <dbReference type="KEGG" id="tpa:TP_0933"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_12"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000101964" description="UDP-N-acetylmuramyl-tripeptide synthetase">
        <location>
            <begin position="1"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <sequence length="540" mass="59457" checksum="BCC82A241A083E6B" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83905</accession>
    <name>O83905_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylphosphinothricin-tripetide-deacetylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71262">
        <property type="entry name" value="C71262"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882378.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83905">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0935"/>
    <dbReference type="ESTHER" id="trepa-naptd">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65892">
        <property type="protein sequence ID" value="AAC65892"/>
        <property type="gene ID" value="TP_0935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76100">
        <property type="protein sequence ID" value="AGN76100"/>
        <property type="gene ID" value="TPANIC_0935"/>
    </dbReference>
    <dbReference type="GeneID" id="57879445"/>
    <dbReference type="KEGG" id="tpa:TP_0935"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.917"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_12"/>
    <dbReference type="OMA" id="CWEALLW"/>
    <dbReference type="OrthoDB" id="1587940at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="73"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="312" mass="34598" checksum="B689979476E2B0BC" modified="1998-11-01" version="1">MGPSRAHVHRMAKKLFKKMRFTPRTSVSALRAGYDDFFYMPYVPNGVDVSCEVLANIETDVLSPRFLMVGHAVLYAHGGFFISGSPMASRALCASLADEVGAKFYIPAYQLAPEHPFPAALENMYDAYVALIDQKKFRPEDIIFSGDGAGAGLMLALTHYLKQKGLVCPRALALISPWVDLTEDRFAGEGVKKKELLLTRDMFRYCALQYTYADNFRNSLVSPLFGNFGDFPPVFVQCGEQELFHTDACALAQILEGAGVQVTLDVWPGMWHLFQSMESVSPCAHIAVARMGAWAHRMLESPAIAVQSLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>O83919</accession>
    <name>O83919_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pheromone shutdown protein (TraB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71261">
        <property type="entry name" value="G71261"/>
    </dbReference>
    <dbReference type="IntAct" id="O83919">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0953"/>
    <dbReference type="EnsemblBacteria" id="AAC65908">
        <property type="protein sequence ID" value="AAC65908"/>
        <property type="gene ID" value="TP_0953"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76118">
        <property type="protein sequence ID" value="AGN76118"/>
        <property type="gene ID" value="TPANIC_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0953"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.937"/>
    <dbReference type="eggNOG" id="COG1916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032780_1_0_12"/>
    <dbReference type="OMA" id="WMGRRTV"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005230">
        <property type="entry name" value="TraB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00261">
        <property type="entry name" value="traB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="396" mass="43076" checksum="40785434EF17F75F" modified="1998-11-01" version="1">MKVVMDHQLTCLEFGSRRVVLMGVACTSQEAIECVRRTIRARRPQCVCVEVDDARAQDLLGMRQWQEYDLARVLREGKGFFLLSTLALSAFQKRLSSGTGVRLGDEVKAAIEVAAELSAQVAYIDRSIEVTLRRAWRVLNPWGRAKLLAVLLSVAFTGEQLSEQRVAVLCAHGAMDGLMQEIISFLPAVKGVLVDERNQYLASKIWAVDSQVVMAVVSAGSVAGVQRCLYEFACGARTAEVTNLETVGSSPHAGQLLGWLFPLLLMGVVVTCFFAGGVGASRDALMQWLWWSGSMTALGVLCALGHPLSIVVGFVGAPIAVLTPIIGVGLFTGFAQAWVCRPQVADMERLADDIVTFRGWYRNKFAHVLLVVVLSSIGAMIGSLISVPMLLMNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83931</accession>
    <name>O83931_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane fusion protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71259">
        <property type="entry name" value="H71259"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882409.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="SMR" id="O83931"/>
    <dbReference type="IntAct" id="O83931">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0965"/>
    <dbReference type="EnsemblBacteria" id="AAC65920">
        <property type="protein sequence ID" value="AAC65920"/>
        <property type="gene ID" value="TP_0965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76130">
        <property type="protein sequence ID" value="AGN76130"/>
        <property type="gene ID" value="TPANIC_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="57879475"/>
    <dbReference type="KEGG" id="tpa:TP_0965"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.949"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_12"/>
    <dbReference type="OMA" id="ATANIIY"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="1">
        <location>
            <begin position="53"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="320" mass="35353" checksum="860841FE865B70EC" modified="1998-11-01" version="1">MTTAQKLLHRKSTIAMVVGILAFLFVLPRLVRALRRVPPPTLSVSKEVVLNRIEISGYIEAAQHQKLESPGEGIVRTVRVQEGDTVKKGQLLFSLENSHQQLDLAEHEFAIEQEEINGVSKKMEIMKLKRNMLQKRLRERYVTAQFDGVVAAFKLSPGQYAKPQDYFGTLIDRSYFKANVEIPEVDASRLKVGQRVEISFPAEPSVKAVGSVTSYPSIARVTSVGRTVVDASIRIDELPEILPGYSFSGAIVAGEQEEILVLKQDGLRYEKGAPFVDRVLPSGKIKSVPVTVEPYVPGFVKIISGLGAGDRVKDQSAARK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-01-11" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>O83942</accession>
    <name>GCH1L_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0977</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71257">
        <property type="entry name" value="G71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882421.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83942"/>
    <dbReference type="SMR" id="O83942"/>
    <dbReference type="STRING" id="243276.TPANIC_0977"/>
    <dbReference type="EnsemblBacteria" id="AAC65932">
        <property type="protein sequence ID" value="AAC65932"/>
        <property type="gene ID" value="TP_0977"/>
    </dbReference>
    <dbReference type="GeneID" id="57879486"/>
    <dbReference type="KEGG" id="tpa:TP_0977"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_3_0_12"/>
    <dbReference type="OMA" id="HGLFWRG"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000147341" description="GTP cyclohydrolase 1 type 2 homolog">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0AFP6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="286" mass="30882" checksum="94FBB294BBBC48F6" modified="1998-11-01" version="1">MTARELDAYFRSFLNFGPFVSCDVALNGLQVANSGAPVHKVAFAVDACAQSIDAAARAGARMLFVHHGLFWGRIEPLTGMQYRRVQALLTHDIALYAVHLPLDAHPQYGNNAGLAARVGLRQGGPFGFIRGTAVGLWGTVAENTTPSQEAMQQHAACTAPDTHRVTHANAISPSAGLSLQQVVHRLFPAEEQPVRLLPFGKQRIERVGILSGKAGTYLAEAIALDLDLFITGEIEHSCYHTAREHSISVIAGGHYQTETVGLQLVARKLQRDTGIETLFLDIPTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>O83944</accession>
    <name>O83944_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71258">
        <property type="entry name" value="A71258"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882423.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83944">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0979"/>
    <dbReference type="EnsemblBacteria" id="AAC65934">
        <property type="protein sequence ID" value="AAC65934"/>
        <property type="gene ID" value="TP_0979"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76143">
        <property type="protein sequence ID" value="AGN76143"/>
        <property type="gene ID" value="TPANIC_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="57879488"/>
    <dbReference type="KEGG" id="tpa:TP_0979"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.964"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_12"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="257" mass="28974" checksum="92CB6367CA895FBE" modified="1998-11-01" version="1">MQIFDTHAHIGLIHPDPVERLRVVQEARRASVTRIMSICNSLHDFAAVYETLQFSPSVYHAVGVSPSEVMAPGKDWIDTIQKSLQLPQVVALGETGLDYCKKYGDKRSQIGLFITQLDIASKAKKPVIIHNRGAGQDILDILSERIPDQGGVFHCYSEDAEYARMALDLPVYFSFAGNLTYRNARNLHETVLALPLDRILVESESPFMSPATYRNKRNRPAHTVETVEFMAELLDMDMLELADQLWKNSCACFHLPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>O83956</accession>
    <name>RUBR_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Rubredoxin</fullName>
            <shortName>Rd</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0991</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71256">
        <property type="entry name" value="G71256"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882435.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83956"/>
    <dbReference type="SMR" id="O83956"/>
    <dbReference type="IntAct" id="O83956">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0991"/>
    <dbReference type="EnsemblBacteria" id="AAC65947">
        <property type="protein sequence ID" value="AAC65947"/>
        <property type="gene ID" value="TP_0991"/>
    </dbReference>
    <dbReference type="GeneID" id="57879500"/>
    <dbReference type="KEGG" id="tpa:TP_0991"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_12"/>
    <dbReference type="OMA" id="APKDMFE"/>
    <dbReference type="OrthoDB" id="2047418at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000135050" description="Rubredoxin">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="52" mass="5568" checksum="A76C9F012A70F1E1" modified="1998-11-01" version="1">MGTYMCDLCGWGYNPEVGDADGGIPAGTAFENLPDHWECPLCGVDKTSFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="141" xmlns="http://uniprot.org/uniprot">
    <accession>O83976</accession>
    <name>O83976_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TP_1012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71252">
        <property type="entry name" value="H71252"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882456.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1012"/>
    <dbReference type="EnsemblBacteria" id="AAC65963">
        <property type="protein sequence ID" value="AAC65963"/>
        <property type="gene ID" value="TP_1012"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76176">
        <property type="protein sequence ID" value="AGN76176"/>
        <property type="gene ID" value="TPANIC_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="57879523"/>
    <dbReference type="KEGG" id="tpa:TP_1012"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.998"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_12"/>
    <dbReference type="OMA" id="YQRWLAE"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAC65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="311" mass="35114" checksum="C6816D44D28867C8" modified="1998-11-01" version="1">MLSIWYVPFEQKEYSVRQMQFRHDENTLTAYLNDLKRIPLMNEKEEYACACAAYAGDAQAKNALVRANVRFVISVARHYRTCGLPLADLISEGNIGLLTAAERFNPARGCRFISYAACWIRQSILKALNEKARIIRLPVSRIRAAKSTYEYIPPVTSVNVGISKTQGGNRYGKRRATMCRAVPTVEEVHIWHTPLSLDAPLGASGSRGESGDVDGLRIGDCVPDDLYAQPEEHMLACALQADIAKILRLLPARDAQVIRYRFGLGGYERRSLQEIGEIFQITKERVRQIEKKALLRIRSCARQHRLDSYIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83977</accession>
    <name>CH10_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">TP_1013</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71253">
        <property type="entry name" value="A71253"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882457.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83977"/>
    <dbReference type="SMR" id="O83977"/>
    <dbReference type="IntAct" id="O83977">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1013"/>
    <dbReference type="EnsemblBacteria" id="AAC65964">
        <property type="protein sequence ID" value="AAC65964"/>
        <property type="gene ID" value="TP_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1013"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_12"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000174890" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="88" mass="9441" checksum="19D5C86B1EC6079B" modified="1998-11-01" version="1">MKIIPLADRVLVKTDKSETKTASGIIIPDTAQEKMQSGTVIAVGSDSEKIKVSVGQRVMHDKYAGNPVKIDGEEHLLLKGADILAVIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83983</accession>
    <name>GATA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName>Glu-ADT subunit A</shortName>
            <ecNumber>6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gatA</name>
        <name type="ordered locus">TP_1020</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71253">
        <property type="entry name" value="H71253"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882464.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83983"/>
    <dbReference type="SMR" id="O83983"/>
    <dbReference type="IntAct" id="O83983">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1020"/>
    <dbReference type="EnsemblBacteria" id="AAC65970">
        <property type="protein sequence ID" value="AAC65970"/>
        <property type="gene ID" value="TP_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1020"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_12"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105224" description="Glutamyl-tRNA(Gln) amidotransferase subunit A">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="506" mass="54102" checksum="F12BF02DB47FE3CC" modified="1998-11-01" version="1">MDAHAITCASWNMLKAQLEAGAISSLQIVRAFRNVYEEDTRSASPLGALVEFFSDAEEHARTADNLRASCAQSTKTAGANGGSVSGKPLLGLPFAVKDNISVKGKHCTCGSKLLADYRAPYDATVVARLRAAGAIPLGRTNMDEFAMGSSTEYSVYGPTRNPRDRSRTSGGSSGGSAAAVAGGQAPFALGTETGGSVRLPAAYCGLYGLKPTYGLLSRYGVVAFGSSLDQIGFFATCIDDIALALSVTSGKDLYDSTSTCPPPATGRHAVSHHLAPFSAHECSILRAAVPRELVDAPGVHPDVSAQFQRFLTWLRAQNVQVEEVTLPALQAAVPVYYLVATAEAASNLARFDGIRYGQRGDTDALLENYYRAVRTSGFGPEVQRRIIVGNYVLSRHFSGDYYRTSVRVRSRIEQECTQLLCSYHFIVCPTAATGAFPLGERIHDPLAMYCSDLFTTFVNLARLPALSVPVGTSGTGLPIGIQIIGSQWQECAVLRLAKRWEEAPHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O83986</accession>
    <name>RECX_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">recX</name>
        <name type="ordered locus">TP_1023</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71251">
        <property type="entry name" value="B71251"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83986"/>
    <dbReference type="SMR" id="O83986"/>
    <dbReference type="IntAct" id="O83986">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1023"/>
    <dbReference type="EnsemblBacteria" id="AAC65974">
        <property type="protein sequence ID" value="AAC65974"/>
        <property type="gene ID" value="TP_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1023"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_2_0_12"/>
    <dbReference type="OMA" id="SETIHAN"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000162490" description="Regulatory protein RecX">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="164" mass="18874" checksum="4D4DAFD9D5E0A076" modified="1998-11-01" version="1">MGTRPTDEQYGAVCFACRCYEAECVAVRLLARSETSAQQLGFKLLKRGFEKRVVESVFPVLKRYSWLDDTRFARAWLRNRVDSRPASRAQLLGELKRRGVSHADAEGALDLLFQEQDEETLCLRLLEKLRRRGYGPHTLQRALQRRQFSPSLVRRCLAVETEGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83987</accession>
    <name>RS9_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">rpsI</name>
        <name type="ordered locus">TP_1024</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71251">
        <property type="entry name" value="C71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882468.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83987"/>
    <dbReference type="SMR" id="O83987"/>
    <dbReference type="IntAct" id="O83987">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1024"/>
    <dbReference type="EnsemblBacteria" id="AAC65981">
        <property type="protein sequence ID" value="AAC65981"/>
        <property type="gene ID" value="TP_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_1024"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_12"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000111433" description="30S ribosomal protein S9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="129" mass="14252" checksum="62A71BEDB2DDDCD8" modified="1998-11-01" version="1">MKNLGIGTGRRKTAVARVCIRMGNGNVTVNRRDVGAYFPTAEQLRRVREPLFATANERRYDVIVNVYGGGLDGQAGACAHGIARALVRADASNQASLRAGGLLTRDSRMVERKKYGQRGARRRFQFSKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>O83990</accession>
    <name>UDP_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uridine phosphorylase</fullName>
            <shortName>UPase</shortName>
            <shortName>UrdPase</shortName>
            <ecNumber>2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">udp</name>
        <name type="ordered locus">TP_1027</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71251">
        <property type="entry name" value="F71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882471.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83990"/>
    <dbReference type="SMR" id="O83990"/>
    <dbReference type="STRING" id="243276.TPANIC_1027"/>
    <dbReference type="EnsemblBacteria" id="AAC65977">
        <property type="protein sequence ID" value="AAC65977"/>
        <property type="gene ID" value="TP_1027"/>
    </dbReference>
    <dbReference type="GeneID" id="57879539"/>
    <dbReference type="KEGG" id="tpa:TP_1027"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_12"/>
    <dbReference type="OMA" id="NLVEGTQ"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000063190" description="Uridine phosphorylase">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="258" mass="27920" checksum="247ABA619316D72D" modified="1998-11-01" version="1">MKLVYSTDCEYHIGLKASDIGHYVILPGDPARSEKIAQHFSHPHKVGHNREYVTYTGTLCETPVSVMSTGIGGPSTAIGVEELIHLGAHTFIRVGTSGGMQPDILAGTVVIATGAIRFEGTSKEYAPVEFPAVPDFTVTAALKHAAEDVQVRHALGVVQCKDNFYGQHSPHTMPVHAELTQKWHAWIACNTLASEMESAALFVLGSVRRVRTGAVLLVIGNQTRRAQGLEDIQVHDTENAIRVAVEAVKLLITQDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="133" xmlns="http://uniprot.org/uniprot">
    <accession>O83991</accession>
    <name>O83991_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TP_1028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Nichols</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71251">
        <property type="entry name" value="G71251"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882472.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_1028"/>
    <dbReference type="EnsemblBacteria" id="AAC65978">
        <property type="protein sequence ID" value="AAC65978"/>
        <property type="gene ID" value="TP_1028"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN76192">
        <property type="protein sequence ID" value="AGN76192"/>
        <property type="gene ID" value="TPANIC_1028"/>
    </dbReference>
    <dbReference type="GeneID" id="57879540"/>
    <dbReference type="KEGG" id="tpa:TP_1028"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.1016"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_12"/>
    <dbReference type="OMA" id="HCANILI"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="292"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAC65978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="670" mass="75400" checksum="C3B1767960C6C840" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>P96129</accession>
    <name>Y688_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Putative carboxypeptidase TP_0688</fullName>
            <ecNumber>3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0688</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1996-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Barnes N.Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-"/>
    <dbReference type="EMBL" id="U70661">
        <property type="protein sequence ID" value="AAB38706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71292">
        <property type="entry name" value="E71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882133.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P96129"/>
    <dbReference type="SMR" id="P96129"/>
    <dbReference type="IntAct" id="P96129">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0688"/>
    <dbReference type="MEROPS" id="S66.003"/>
    <dbReference type="EnsemblBacteria" id="AAC65657">
        <property type="protein sequence ID" value="AAC65657"/>
        <property type="gene ID" value="TP_0688"/>
    </dbReference>
    <dbReference type="GeneID" id="57879213"/>
    <dbReference type="KEGG" id="tpa:TP_0688"/>
    <dbReference type="eggNOG" id="COG1619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034346_1_1_12"/>
    <dbReference type="OMA" id="MLTQWRL"/>
    <dbReference type="OrthoDB" id="952832at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000172847" description="Putative carboxypeptidase TP_0688">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="337" mass="37958" checksum="959513EDCECE4993" modified="1997-05-01" version="1">MQDEGVDMKKLLLRSSDEVRVIAPSCSMRKIDSSVIERAQERFRCLGLNVAFGDHVYDEDFLGSASVDKRVADLHAAFADKKVKLILTAIGGFNSNQLLQHIDYALLKKNPKLLCGFSDVTALLNAIHAKTGMPVFYGPHFSTFGMEKGIEFTIECFKNTFFYGRCDILASETWSDDMWFKDQEHRQFITNPGYEIIHRGDMVGMGVGGNISTFNLLAGTEYEPSLKKSILFIEDTSRMSITDFDRHLEALTQRDDFCTVRGILIGRFQKDSGIDMDMLRKIISRKKALDAIPLFANVDFGHTTPHCILPIGGMIRVNVDRKCITVQLHSSVEQLPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q56339</accession>
    <name>FLHF_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthesis protein FlhF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Flagella-associated GTP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">flhF</name>
        <name type="ordered locus">TP_0713</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="DNA Seq." volume="7" first="107" last="116">
            <title>Identification and sequences of the Treponema pallidum flhA, flhF, and orf304 genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Young N.R."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="9063647"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71290">
        <property type="entry name" value="E71290"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882158.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56339"/>
    <dbReference type="SMR" id="Q56339"/>
    <dbReference type="IntAct" id="Q56339">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0713"/>
    <dbReference type="EnsemblBacteria" id="AAC65679">
        <property type="protein sequence ID" value="AAC65679"/>
        <property type="gene ID" value="TP_0713"/>
    </dbReference>
    <dbReference type="GeneID" id="57879238"/>
    <dbReference type="KEGG" id="tpa:TP_0713"/>
    <dbReference type="eggNOG" id="COG1419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_11_4_12"/>
    <dbReference type="OMA" id="WYEVDEY"/>
    <dbReference type="OrthoDB" id="1162441at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020006">
        <property type="entry name" value="FlhF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF3">
        <property type="entry name" value="PTHR43134:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03499">
        <property type="entry name" value="FlhF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000101226" description="Flagellar biosynthesis protein FlhF">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="437" mass="49284" checksum="FBDFA22D4599BED0" modified="1996-11-01" version="1">MELLVEVAPTKEKAIEKIRKKYGDRVNILRTQRNNRSFFFGLIERVSVEIFFSVNSGSQSSVHEIPSVQSRTRVSAARVEDTEAEKIKILESAQRINAKIAQQVEPLISAAKEKKTEKVPTSPEAVHALTQTLEGMIQKITNSAPVVIAQELQSIQRIELLLEENDFSFSFIRKSIARLKDELSYHDLESFEKVESTVLRWIIESVHIQVPPICTGTRNIVLVGPTGVGKTTTLAKLAAFYFVTEPKRTGIQPRVKIITTDNFRIGAAFQMERYCELMGLDLCVVQAPVEFLTYMTLYQQETDVVFVDTEGRSPVDGQNIERMVEYFRAVKNFELEVYLTIDAGSKANDLREVFKQYALFEYRALIVTKLDETTSIGNLISALSEARTPITYITTGQTVPSNLEKASVNLLLSKLKGFKLLAEEMGNDYGDYGSKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUN7</accession>
    <name>F7IUN7_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein (Mcp2-3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TP_0640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71298">
        <property type="entry name" value="G71298"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882085.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0640"/>
    <dbReference type="EnsemblBacteria" id="AAC65614">
        <property type="protein sequence ID" value="AAC65614"/>
        <property type="gene ID" value="TP_0640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75820">
        <property type="protein sequence ID" value="AGN75820"/>
        <property type="gene ID" value="TPANIC_0640"/>
    </dbReference>
    <dbReference type="GeneID" id="57879165"/>
    <dbReference type="KEGG" id="tpa:TP_0640"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.633"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_12"/>
    <dbReference type="OMA" id="MHIADET"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="328"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAC65614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="614" mass="67270" checksum="B9652EA9271EEC6C" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>O83139</accession>
    <name>O83139_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein (CcdA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71367">
        <property type="entry name" value="A71367"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881550.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83139">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0101"/>
    <dbReference type="EnsemblBacteria" id="AAC65096">
        <property type="protein sequence ID" value="AAC65096"/>
        <property type="gene ID" value="TP_0101"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75320">
        <property type="protein sequence ID" value="AGN75320"/>
        <property type="gene ID" value="TPANIC_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0101"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.101"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_2_0_12"/>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="264" mass="28218" checksum="DFE37CAF569C9E3C" modified="1998-11-01" version="1">MTSVPGVVGSFLAGLLSFLSPCVLPLIPAYVSFISGESLGSIRAGAARLQVFLSSVFFVLGLTTVFVLFSIVFSGGVQLAGAGVLTVLTRVAGVGVILLGLNTIFDVVPFLRVERRMHTTVRRVGVFRAYLFGLLFATGWTPCVGPILSSLLFYAASSGQLLHAAGLLTVYALGLGLPFVFAGIFFGRAERVFAWVKSHMHAVKLASGMLIVFFGLLMLTSGLQALSRLFLRAGFALEEYSTRGITPLRQIAALLAQWFLYQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>O83167</accession>
    <name>O83167_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71362">
        <property type="entry name" value="G71362"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881579.1">
        <property type="nucleotide sequence ID" value="NC_000919.1"/>
    </dbReference>
    <dbReference type="IntAct" id="O83167">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0130"/>
    <dbReference type="EnsemblBacteria" id="AAC65122">
        <property type="protein sequence ID" value="AAC65122"/>
        <property type="gene ID" value="TP_0130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75352">
        <property type="protein sequence ID" value="AGN75352"/>
        <property type="gene ID" value="TPANIC_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0130"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.136"/>
    <dbReference type="HOGENOM" id="CLU_1958604_0_0_12"/>
    <dbReference type="OMA" id="GKKAHIK"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15094" checksum="B84AFA3A5AB316D6" modified="1998-11-01" version="1">MGRPPASKASNVFKDVFLTNAMDMQTHDCARSMGHKKNGANGDIGADCVSVETRSASQAMPWALHLKLVAPEPSGKEAHIKGQTRPASYRLGGQRQSGQGPSRNSQHVRRYEQKGHAPCCSCCSYEVEGRILLSMPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83179</accession>
    <name>O83179_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TP_0143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71361">
        <property type="entry name" value="A71361"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881591.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0143"/>
    <dbReference type="EnsemblBacteria" id="AAC65131">
        <property type="protein sequence ID" value="AAC65131"/>
        <property type="gene ID" value="TP_0143"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75363">
        <property type="protein sequence ID" value="AGN75363"/>
        <property type="gene ID" value="TPANIC_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0143"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.148"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_5_2_12"/>
    <dbReference type="OMA" id="PLYLFQL"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="112"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="402"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAC65131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="593" mass="64883" checksum="5D2E3F9189AA9FCB" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>O83240</accession>
    <name>RS13_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">TP_0210</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="H71351">
        <property type="entry name" value="H71351"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881658.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83240"/>
    <dbReference type="SMR" id="O83240"/>
    <dbReference type="IntAct" id="O83240">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0210"/>
    <dbReference type="EnsemblBacteria" id="AAC65199">
        <property type="protein sequence ID" value="AAC65199"/>
        <property type="gene ID" value="TP_0210"/>
    </dbReference>
    <dbReference type="GeneID" id="57878748"/>
    <dbReference type="KEGG" id="tpa:TP_0210"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_12"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132162" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="121" mass="13634" checksum="609620F940CA059B" modified="1998-11-01" version="1">MARIAGVDLPNKHVSVALTYIYGISRSSARTICEKARISSACLINDLSQDELAVVRAIIDREYKVEGRLRTEVALNIKRLMDIGCYRGLRHRKGLPVRGQRTRTNARTRKGKRKTVAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83330</accession>
    <name>O83330_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter, periplasmic binding protein (HisJ)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71339">
        <property type="entry name" value="F71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881757.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83330">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0308"/>
    <dbReference type="EnsemblBacteria" id="AAC65297">
        <property type="protein sequence ID" value="AAC65297"/>
        <property type="gene ID" value="TP_0308"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75512">
        <property type="protein sequence ID" value="AGN75512"/>
        <property type="gene ID" value="TPANIC_0308"/>
    </dbReference>
    <dbReference type="GeneID" id="57878844"/>
    <dbReference type="KEGG" id="tpa:TP_0308"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.308"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_12"/>
    <dbReference type="OMA" id="IFATYSI"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="65"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="321" mass="36060" checksum="3D50EB2875E344C8" modified="1998-11-01" version="1">MHCLMQVPSRRDGALRVQRCDGCVVWRSVCCALLVALLCLAVGCDSPDLLVDSDLSLSRVRVAKTLVMGVSDRTPPMCFRYPNGEIVGFDVDLARAVCRVLGVRLIIRPIKWTLKRNALRCGLVDCVWTAFAVTARRRTEFLLSEPYLRTAQVLLVREGRLHPDLAHVERELGQRMTGVSAVHTRGDILPMRSSHRQARIAVLRGGPVPGNEKWQFGFEPHGKVVWYRHRSAMLEALRTRAVDAALVDLVEAHDAVHRQGAPLRVMRVPLGLSQYAVAFRREDRALRDEIQRILYRIAASGEAYRIAEKWFGVGQSVIGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>O83331</accession>
    <name>O83331_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amino acid ABC transporter, periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71339">
        <property type="entry name" value="G71339"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881758.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0309"/>
    <dbReference type="EnsemblBacteria" id="AAC65298">
        <property type="protein sequence ID" value="AAC65298"/>
        <property type="gene ID" value="TP_0309"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75513">
        <property type="protein sequence ID" value="AGN75513"/>
        <property type="gene ID" value="TPANIC_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0309"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.309"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_12"/>
    <dbReference type="OMA" id="WFGIDVS"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="49"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="272" mass="30406" checksum="366A09A8087C8233" modified="1998-11-01" version="1">MLWSCTPRARVFHAQDASFDEARVRGTLVVGVGRGLAPLVDAATFSAFSLPSSVVPPPARCSLLLQEARGYDVELLAQVARRLHMDVQVKVVHWDEKERALHAGVIDCIADGFTYTADHARRFALTQPYVRDVRVFAVLRQAPYATVADLHGKRLGVHAVTDVEENDAYHALFGQVKTYAHYVQALTALSRAEVDVVALNLVTLCAVTPHLRRLYRILDEPIDTCEYVFAFRADARALRDMVVRTLSQLQREGFVSALSKRWFGSDMSIIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83337</accession>
    <name>O83337_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpr protein G (TprG)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TP_0317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71340">
        <property type="entry name" value="F71340"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881765.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0317"/>
    <dbReference type="EnsemblBacteria" id="AAC65301">
        <property type="protein sequence ID" value="AAC65301"/>
        <property type="gene ID" value="TP_0317"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75518">
        <property type="protein sequence ID" value="AGN75518"/>
        <property type="gene ID" value="TPANIC_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0317"/>
    <dbReference type="PATRIC" id="fig|243276.5.peg.335"/>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="HKGNPMS"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSP_N" evidence="1">
        <location>
            <begin position="96"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="2">
        <location>
            <begin position="553"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAC65301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="756" mass="81325" checksum="4D1FF6B8CE51738A" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>O83359</accession>
    <name>O83359_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71338">
        <property type="entry name" value="A71338"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881787.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83359">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0339"/>
    <dbReference type="EnsemblBacteria" id="AAC65324">
        <property type="protein sequence ID" value="AAC65324"/>
        <property type="gene ID" value="TP_0339"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75537">
        <property type="protein sequence ID" value="AGN75537"/>
        <property type="gene ID" value="TPANIC_0339"/>
    </dbReference>
    <dbReference type="GeneID" id="57878869"/>
    <dbReference type="KEGG" id="tpa:TP_0339"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.337"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_12"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="331" mass="37742" checksum="7894833B2880E58F" modified="1998-11-01" version="1">MSYSCSAESTSVCSVHFSVFRIPGATCRCDVFCAEHVFFCARSQLKRIVRALCVNGHTAKFSRPLHVRDRVSFEWVRSVPPALIPENISLSILFENEDIIAVNKAQGMIVHPGAGHWTGTLVQALSFYRVYRARFEDEFSRQFQKGFPDFFSTLRQGIVHRLDKDTSGVLLTSRNMHAHEALVRSFKKRQVRKVYLALLQGVPARGVGVIETTIVRDRRRRTRFVASEDFSKGKYARTRYKVMKICGACAFVQFLLDTGRTHQIRVHARYLGCPVVGDPLYGSRNICGIPTTLMLHAYAVRFVLPRTKKRITLVAPIPLRFVRLIHRLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83380</accession>
    <name>O83380_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophosphatidic acid acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TP_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71334">
        <property type="entry name" value="G71334"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0361"/>
    <dbReference type="EnsemblBacteria" id="AAC65346">
        <property type="protein sequence ID" value="AAC65346"/>
        <property type="gene ID" value="TP_0361"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75558">
        <property type="protein sequence ID" value="AGN75558"/>
        <property type="gene ID" value="TPANIC_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0361"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.360"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102396_0_0_12"/>
    <dbReference type="OMA" id="HEHAMIP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="88"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAC65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="282" mass="31700" checksum="DEF69003CD6C61AD" modified="1998-11-01" version="1">MLPCAVVNQRRRSALMCGILSIVVSIAVLAPLAVANTLCYALYRPGCRWVNHAVSTWGARTIFAVLHTYGRLKFYSDYTHAEHLPTQYLVVSNHQSVLDTPALMRYFGYIDAPRLRFVAKRELARFVPLVSTMLKSGRHCLVDRHQSGAQAMQALETFTHHVMRERWLPVIFPEGTRSRNGALRIFHAAGFRALTARLPLPVVVCALDGGWNLRPLLKIGQKLKGSAYRVKVLGVYPAPHNKDEQLSLLREAKALIQAQLDVWRSETTCPQDECLTRASKDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>O83387</accession>
    <name>RL25_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name evidence="1" type="synonym">ctc</name>
        <name type="ordered locus">TP_0372</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71333">
        <property type="entry name" value="C71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881820.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83387"/>
    <dbReference type="SMR" id="O83387"/>
    <dbReference type="IntAct" id="O83387">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0372"/>
    <dbReference type="EnsemblBacteria" id="AAC65357">
        <property type="protein sequence ID" value="AAC65357"/>
        <property type="gene ID" value="TP_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="57878901"/>
    <dbReference type="KEGG" id="tpa:TP_0372"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_0_12"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000181612" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <sequence length="196" mass="21619" checksum="7E4375DFCFC64065" modified="1998-11-01" version="1">MDERRLKGKRRVQLGKYAAVRGRKEGRLPAVMYDHRGVSVPLELAQQDFDRLFRALTRSTVLSLELDGGEVFCVFVKDYQHNMVSDRVEHVDFYAVEESVPLRMRIRLQLCGSPEGVRYGARLEKGLSYIEVESLPRNLPDRVVLDISGLGAGDVRRVRDVPLPASVVVLSDPDAVIVALSSSASEAGSPAGARTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>O83388</accession>
    <name>TILS_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tilS</name>
        <name type="ordered locus">TP_0373</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71333">
        <property type="entry name" value="D71333"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881821.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83388"/>
    <dbReference type="SMR" id="O83388"/>
    <dbReference type="IntAct" id="O83388">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0373"/>
    <dbReference type="EnsemblBacteria" id="AAC65358">
        <property type="protein sequence ID" value="AAC65358"/>
        <property type="gene ID" value="TP_0373"/>
    </dbReference>
    <dbReference type="GeneID" id="57878902"/>
    <dbReference type="KEGG" id="tpa:TP_0373"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_12"/>
    <dbReference type="OMA" id="SERDQEY"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000181796" description="tRNA(Ile)-lysidine synthase">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <sequence length="477" mass="52606" checksum="BAAECB430759DCF8" modified="1998-11-01" version="1">MSESRQKLHPLLVHVARSFGHFLVPRKPSCLLVAVSGGADSLALLYAAHELAPDFGVCACAVTVDHSLRAQEGALDARFVRALCARFSPPLPCFVQQISAGAVHACAKIRGRGVQDAARALRYKVFDHVAARCGAQVVLTAHTRDDQYETLLMRLFQGAAASALQGIRAARGRYVRPLLKVSRTCVEDFLQTRGVRWREDASNTCRKYVRNRIRHELIPALDAVLAGWRSGLDKTFAGISAEHSFCVAALTRWREGCSHAWEPVPRALGTRLRMPRSDFLAAEFILRFFLLQEACVRLGVSHRVPRGALERCARFDGVRRIHVSGLQLERAGAYVLFSCIHASDTARETKKQDAGSPPSSEKQGVSAIYVARPGAYPCACGTLLVEVRPAGVFVCCAQDHVGVGPFSFPFYIRTHRTGDTISIRGGHKGIRKMFSEWHVPLSDRTVLPMIEQDGVLRALYGAALGYQNRYAERTPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>O83400</accession>
    <name>O83400_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="C71331">
        <property type="entry name" value="C71331"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0385"/>
    <dbReference type="EnsemblBacteria" id="AAC65369">
        <property type="protein sequence ID" value="AAC65369"/>
        <property type="gene ID" value="TP_0385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75579">
        <property type="protein sequence ID" value="AGN75579"/>
        <property type="gene ID" value="TPANIC_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0385"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.385"/>
    <dbReference type="eggNOG" id="ENOG5032IEC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163435_0_0_12"/>
    <dbReference type="OMA" id="IWVITIP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14301" checksum="4AF5160D09371C5C" modified="1998-11-01" version="1">MREKGAMREKQRRGIPRRQRGMTVQKVSALFFTVSIPVLLCAGVWQASRYQAVERVVREYDAEQHRIIAENKRKISGIAILSKPDRIEKLAVEKLHLHRASHAEIVRIKLRPAHKDSSPHASEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>O83475</accession>
    <accession>O83476</accession>
    <name>Y462_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0462/TP_0463</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0462/TP_0463</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TP013X lipoprotein family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAC65456" version="1"/>
        </conflict>
        <text>Produces two separate ORFs.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65455.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65456.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71321">
        <property type="entry name" value="A71321"/>
    </dbReference>
    <dbReference type="PIR" id="H71320">
        <property type="entry name" value="H71320"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83475"/>
    <dbReference type="IntAct" id="O83475">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0462"/>
    <dbReference type="EnsemblBacteria" id="AAC65455">
        <property type="protein sequence ID" value="AAC65455"/>
        <property type="gene ID" value="TP_0462"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65456">
        <property type="protein sequence ID" value="AAC65456"/>
        <property type="gene ID" value="TP_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0462"/>
    <dbReference type="KEGG" id="tpa:TP_0463"/>
    <dbReference type="HOGENOM" id="CLU_056007_0_0_12"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000018068" description="Uncharacterized lipoprotein TP_0462/TP_0463">
        <location>
            <begin position="20"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="392" mass="40261" checksum="F2689260172607AE" modified="2001-06-01" version="2" precursor="true">MRRIVCPPVLFLSASLLTGCDFSGIFASIQSEVPLKIPSIRGVVTGLVKCNNKLYACAGQLWEKDASKSEGKWTAVNFLPGKKITSIVSKGACVYACVSGEGVYTYTSNGAGRTGGTTTPSTVLGKTNGAIRIGGSDNPFLQMPCELSSGSSGGGGGGSGSSSDGGIKNGSDENVLGSGTGYVVTTKAVYTKSNSSGTSCTYTKDGTFTATTSPILGCTSDGKGCFYVLDGTDVHCRTVQASGGGNGAHCAVASGSATSCKVAHTVTNPLCIAHVKNGQTEFLLIGGSQGYKEIKLETGSGSGTGCLKAENVRGPEQWGEDSVTPKDRVSQYEGTIGRFAISDIYTVESTSGAGGTNGGTNKPDVYVVVGDSQDGYTGLWRFDAQKKEWNRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O83506</accession>
    <name>RPOD_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Major vegetative sigma factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoD</name>
        <name type="ordered locus">TP_0493</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71318">
        <property type="entry name" value="E71318"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881942.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83506"/>
    <dbReference type="SMR" id="O83506"/>
    <dbReference type="STRING" id="243276.TPANIC_0493"/>
    <dbReference type="EnsemblBacteria" id="AAC65480">
        <property type="protein sequence ID" value="AAC65480"/>
        <property type="gene ID" value="TP_0493"/>
    </dbReference>
    <dbReference type="GeneID" id="57879015"/>
    <dbReference type="KEGG" id="tpa:TP_0493"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_7_2_12"/>
    <dbReference type="OMA" id="RIEMYYE"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0731">Sigma factor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000093930" description="RNA polymerase sigma factor RpoD">
        <location>
            <begin position="1"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="1">
        <location>
            <begin position="377"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="1">
        <location>
            <begin position="456"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="1">
        <location>
            <begin position="545"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC">
        <location>
            <begin position="401"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <sequence length="611" mass="70902" checksum="D69EEB0B1ABB314C" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-12-01" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>O83558</accession>
    <name>ISPH_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="1">HMBPP reductase</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH</name>
        <name type="synonym">lytB</name>
        <name type="ordered locus">TP_0547</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71310">
        <property type="entry name" value="G71310"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010881994.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83558"/>
    <dbReference type="SMR" id="O83558"/>
    <dbReference type="IntAct" id="O83558">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0547"/>
    <dbReference type="EnsemblBacteria" id="AAC65533">
        <property type="protein sequence ID" value="AAC65533"/>
        <property type="gene ID" value="TP_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0547"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_0_1_12"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000128886" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="376" mass="38885" checksum="A9D516E4C6DDE6E6" modified="1998-11-01" version="1">MRKVNCIKVITRAHTLGYCGGVRMAVRMAEHARAHHRGSVYTLGPLVHNPVTLARLRARGIECLDPAHLSFALHAPAAPGAAPHAVEEKTARTVVIRAHGVAPEVYEALERSGAQVVDATCPRVKESQRRAQGFAAQGLHVILAGDRNHGEIVGIEGYVRAGAAQACSHLPGGAPDGMLPQVQCFVVQNAREAAALPCLARAALLAQTTITQGEYDAIAAAARTRVRELTVARTICAATARRQAALRALAPTVEALLVIGGAHSANTQRLLHTARETSLPTWLVERVEDIPPDIYAFSAVGISAGASTPDCVIAAVEQALRTGGAPVASRVSSSALPKVSTCRAVCAAATSSVGSAGASGAVSPGAVRPFAVGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>O83643</accession>
    <name>O83643_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TP_0636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71301">
        <property type="entry name" value="A71301"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882081.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="IntAct" id="O83643">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0636"/>
    <dbReference type="EnsemblBacteria" id="AAC65610">
        <property type="protein sequence ID" value="AAC65610"/>
        <property type="gene ID" value="TP_0636"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AGN75816">
        <property type="protein sequence ID" value="AGN75816"/>
        <property type="gene ID" value="TPANIC_0636"/>
    </dbReference>
    <dbReference type="GeneID" id="57879158"/>
    <dbReference type="KEGG" id="tpa:TP_0636"/>
    <dbReference type="PATRIC" id="fig|243276.9.peg.629"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090345_0_0_12"/>
    <dbReference type="OMA" id="THGAGHE"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAC65610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="256" mass="28127" checksum="3BAB5577AE8FFDF6" modified="1998-11-01" version="1">MCVASRSWYAQALVLSLSAFGEGHKSVTLFVRLQDEAFILRAALFGGAQSKLRGLVIPYTTGRVWVYSNPRTSMHKIVDFSVTHSRVALRDSIVRVWCAAICVDIIEASKGTISWTLVTAFLDGISLSSDGACKHALLRFLWRVLIGEGVAPNITSCSRCATQYAVSVSGVSRVAYLTQGESFVCAACAAPAEHRFELNAEAWHFLNTVKECTPRHARALVLSQESYCELKQLLFCLITKMSGKKLKTLEHAHAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="1998-11-01" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>O83646</accession>
    <name>O83646_TREPA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting chemotaxis protein (Mcp2-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TP_0639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="F71298">
        <property type="entry name" value="F71298"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0639"/>
    <dbReference type="EnsemblBacteria" id="AAC65613">
        <property type="protein sequence ID" value="AAC65613"/>
        <property type="gene ID" value="TP_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0639"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_12"/>
    <dbReference type="OMA" id="DSHAHVP"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="340"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAC65613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000811"/>
        </source>
    </evidence>
    <sequence length="654" mass="71538" checksum="DE35965B97C65B5E" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>O83688</accession>
    <name>Y690_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0690</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0690</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="G71292">
        <property type="entry name" value="G71292"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882135.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83688"/>
    <dbReference type="IntAct" id="O83688">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0690"/>
    <dbReference type="EnsemblBacteria" id="AAC65664">
        <property type="protein sequence ID" value="AAC65664"/>
        <property type="gene ID" value="TP_0690"/>
    </dbReference>
    <dbReference type="GeneID" id="57879215"/>
    <dbReference type="KEGG" id="tpa:TP_0690"/>
    <dbReference type="eggNOG" id="ENOG5031CXJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229453_0_0_12"/>
    <dbReference type="OMA" id="CNIRGED"/>
    <dbReference type="OrthoDB" id="1866346at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014253" description="Uncharacterized protein TP_0690">
        <location>
            <begin position="27"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <sequence length="193" mass="22604" checksum="6D7AD5BB4CE73992" modified="1998-11-01" version="1" precursor="true">MRNVFVGALCMCGMSFVFSDSVRSAAAAYFSHFSWVMPERVVQEHISWRYKALKQDHMEVDCDVYAYRGGRVFPRVSGMGVIDHTNIPHALRIFCEKMTDSFMKKKIDPHLCQRERKFLPHYFSFRMGKLPRICAVVFAQPNVMQGNFLTVHFKLNVENEDSRIIEVTVAKEQENWKLFQFLFKEDRAHLAVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83691</accession>
    <name>Y693_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized lipoprotein TP_0693</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0693</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71293">
        <property type="entry name" value="B71293"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882138.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83691"/>
    <dbReference type="IntAct" id="O83691">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0693"/>
    <dbReference type="EnsemblBacteria" id="AAC65665">
        <property type="protein sequence ID" value="AAC65665"/>
        <property type="gene ID" value="TP_0693"/>
    </dbReference>
    <dbReference type="GeneID" id="57879219"/>
    <dbReference type="KEGG" id="tpa:TP_0693"/>
    <dbReference type="eggNOG" id="ENOG5031CGG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622461_0_0_12"/>
    <dbReference type="OMA" id="WRCVLFA"/>
    <dbReference type="OrthoDB" id="805997at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000014254" description="Uncharacterized lipoprotein TP_0693">
        <location>
            <begin position="18"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="440" mass="47673" checksum="B6B3BE24EBB66065" modified="1998-11-01" version="1" precursor="true">MDRFFCTVWVWSVLFGACTSQTRSSFSLNADGLNSSGVAHASEHVSHAAAMGNEAGAADASVSESPASFSPGRGSAWVQGTVGHIPAEHHAALQAFFDTEEGMRITDALCTGDTYAAFNELEALYDPSSETDTARSRALHAYVRALLQGIRLAPRVAPPTHVGVSATLQYRDSVWPLQRGRFTLCYQIGPEHGDVMQVTLCADTQGVLFFPFPSAALSQEVTLSFDTAALVHAPSLCAQDSALQERPSSPEPVVSTIPSPEGEENSAAGEPALANLVCRVAAPSSDPKQHPVRRQVSTTICILDYGKTGRPLTHENLTATRLLGGLLKRRFVNIGLDSLYGVGKVPDHAVIARARKKFGGNVRRLVFGLTQVRRLERDSDARWKCVLFAQLHVWDFPKGAYTHHFTAQCTETGDTESQSYVRARTRMGETVLSDVLQCFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>O83715</accession>
    <name>Y733_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0733</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0733</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To T.pallidum TP_0126.</text>
    </comment>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="B71288">
        <property type="entry name" value="B71288"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882178.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83715"/>
    <dbReference type="SMR" id="O83715"/>
    <dbReference type="IntAct" id="O83715">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0733"/>
    <dbReference type="TCDB" id="1.B.6.10.1">
        <property type="family name" value="the ompa-ompf porin (oop) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAC65708">
        <property type="protein sequence ID" value="AAC65708"/>
        <property type="gene ID" value="TP_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0733"/>
    <dbReference type="eggNOG" id="ENOG5034C2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097950_0_0_12"/>
    <dbReference type="OMA" id="YMRFINS"/>
    <dbReference type="OrthoDB" id="1223956at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202312" description="Uncharacterized protein TP_0733">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="219" mass="23327" checksum="E52AD7CB975E9ADE" modified="1998-11-01" version="1">MSRTFRAWQCVGALCALSPLLPAYSSEGVREVPPSQSPQVVVAYEPIRPGDQLLKIGIVAGCQLYIAGGNGTNGSSSSGTNGNGNGKLLGGGGFHLGYEYFFTKNFSLGGQVSFECYRTTGSNYYFSVPITVNPTYTFAVGRWRIPLSLGVGLNIQSYLSKKAPGLIAEASAGLYYQYTPDWSIGGIVAYTQLGDIASSPDKCRAVGLATIDFGVRYHF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>O83780</accession>
    <name>Y802_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized protein TP_0802</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TP_0802</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="D71279">
        <property type="entry name" value="D71279"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83780"/>
    <dbReference type="IntAct" id="O83780">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0802"/>
    <dbReference type="EnsemblBacteria" id="AAC65774">
        <property type="protein sequence ID" value="AAC65774"/>
        <property type="gene ID" value="TP_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0802"/>
    <dbReference type="HOGENOM" id="CLU_2182798_0_0_12"/>
    <dbReference type="OMA" id="NWENGLT"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000202330" description="Uncharacterized protein TP_0802">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <sequence length="109" mass="12262" checksum="8B741EC3D0FB16D9" modified="1998-11-01" version="1">MQHAPTQSQDTPCTRQGCSPFIYARRAGTPLRAARTAKTMQPRETSSCKRKTQYNLGSVTSGAHTITPAHAKLPLAQRYCKFTRVTREQHYPENNWENGLICRTPADTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>O83940</accession>
    <name>RSMI_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="1">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmI</name>
        <name type="ordered locus">TP_0975</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71257">
        <property type="entry name" value="E71257"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882419.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83940"/>
    <dbReference type="SMR" id="O83940"/>
    <dbReference type="STRING" id="243276.TPANIC_0975"/>
    <dbReference type="EnsemblBacteria" id="AAC65931">
        <property type="protein sequence ID" value="AAC65931"/>
        <property type="gene ID" value="TP_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="57879484"/>
    <dbReference type="KEGG" id="tpa:TP_0975"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_12"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000211960" description="Ribosomal RNA small subunit methyltransferase I">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <sequence length="274" mass="29532" checksum="4596A0E7067D12B2" modified="1998-11-01" version="1">MGTLYVVATPIGNLADITLRALDVLRTVDVVACEDTRRTRALLSHFGIHKRLVSCRAHNEAQAARRLIHFLSTPISAFLSPEKGRGRQSARRTRARPGETVGTAALQLAAEATGEQEVCGSPHAQVAYVSDAGTPGVSDPGAVLVRAVRDAGHTVVPIPGASALTTLLSVAGVRDKTVLFEGFLSPHPGRRRARLVQLCAQRVAFVLYESPYRVQKLLEDLVAVAPESQVVLGRELTKVHEELCVGTALRVMESFCARTRVRGECVLLVSAEKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="143" xmlns="http://uniprot.org/uniprot">
    <accession>O83950</accession>
    <name>SYDND_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="1">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">TP_0985</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71256">
        <property type="entry name" value="A71256"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83950"/>
    <dbReference type="SMR" id="O83950"/>
    <dbReference type="IntAct" id="O83950">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0985"/>
    <dbReference type="EnsemblBacteria" id="AAC65942">
        <property type="protein sequence ID" value="AAC65942"/>
        <property type="gene ID" value="TP_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0985"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_12"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000110974" description="Aspartate--tRNA(Asp/Asn) ligase">
        <location>
            <begin position="1"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="551"/>
            <end position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="602" mass="68627" checksum="A51D0B17DE4FC5BC" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>O83984</accession>
    <name>GATB_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName>Asp/Glu-ADT subunit B</shortName>
            <ecNumber>6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">gatB</name>
        <name type="ordered locus">TP_1021</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-"/>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A71254">
        <property type="entry name" value="A71254"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882465.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O83984"/>
    <dbReference type="SMR" id="O83984"/>
    <dbReference type="STRING" id="243276.TPANIC_1021"/>
    <dbReference type="EnsemblBacteria" id="AAC65971">
        <property type="protein sequence ID" value="AAC65971"/>
        <property type="gene ID" value="TP_1021"/>
    </dbReference>
    <dbReference type="GeneID" id="57879533"/>
    <dbReference type="KEGG" id="tpa:TP_1021"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_12"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148861" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="509" mass="56865" checksum="C28B90122236BF52" modified="1998-11-01" version="1">MSDLQTGTVPSIAGATDDTHAAPFFYEVIIGCEIHCQLLTKTKAFCACANRSGGMPNSRVCPVCLGLPGALPVVSEEYVRLGVRAGLALGCTIQLWSAFDRKHYFYPDLPKGYQITQYDAPLCTDGAVDVQGVDMPVQRRVRIERIHLEEDAGKSLHAADAYSYIDFNRCGVPLIEIVSRPDLRSAEEAACFMQTIREILTFIEVTDGNLEEGALRCDANVNVRILYKGQEHHTPISEIKNMNSYRMVRDACTYEVQRQLQEFWQKGPASKEEMQRKRTMGWDPVEGVTLLQRTKHSLRDYRFMRDPDLPDLHLTPAYVQHLSYTVGELPAARRARFKLDLGLSAFAAQTLTGSRMLADWFEKAAHASKNARRVANWILSEVLAVVNEKNICIAELNLSPEAIAELMDAVEDQRITGKQAKDIFAQMLATGARAQDIISAQGLAQLSDEEEIATLVQTVFQEHPKALRDWQHGKTNVAAWLMGQVMKRSRGRAHPARVATLVHQALSQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>P74927</accession>
    <name>FLIM_TREPA</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliM</name>
        <name type="ordered locus">TP_0721</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="J. Bacteriol." volume="178" first="4628" last="4634">
            <title>Organization, transcription, and expression of the 5' region of the fla operon of Treponema phagedenis and Treponema pallidum.</title>
            <authorList>
                <person name="Limberger R.J."/>
                <person name="Slivienski L.L."/>
                <person name="El-Afandi M.C."/>
                <person name="Dantuono L.A."/>
            </authorList>
            <dbReference type="PubMed" id="8755894"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1995" name="Gene" volume="166" first="57" last="64">
            <title>Identification and sequences of the Treponema pallidum fliM', fliY, fliP, fliQ, fliR and flhB' genes.</title>
            <authorList>
                <person name="Hardham J.M."/>
                <person name="Frye J.G."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="8529894"/>
            <dbReference type="DOI" id="10.1016/0378-1119(95)00583-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 190-344</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliM family.</text>
    </comment>
    <dbReference type="EMBL" id="U28219">
        <property type="protein sequence ID" value="AAB61256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U36839">
        <property type="protein sequence ID" value="AAB00543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="E71291">
        <property type="entry name" value="E71291"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882166.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P74927"/>
    <dbReference type="SMR" id="P74927"/>
    <dbReference type="IntAct" id="P74927">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0721"/>
    <dbReference type="EnsemblBacteria" id="AAC65687">
        <property type="protein sequence ID" value="AAC65687"/>
        <property type="gene ID" value="TP_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0721"/>
    <dbReference type="eggNOG" id="COG1868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052646_0_0_12"/>
    <dbReference type="OMA" id="NPQFTQI"/>
    <dbReference type="OrthoDB" id="1748746at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01397">
        <property type="entry name" value="fliM_switch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0283">Flagellar rotation</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180932" description="Flagellar motor switch protein FliM">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="344" mass="38553" checksum="A2AC419677449737" modified="1998-01-01" version="2">MTEVLSQDEIDQLLTAISSGDASIEDARPISDTRKITLYDFRRPDKFSKEQMRTLSLMHETFARLTTTSLSAQLRSMVHVHVASVDQLTYEEFIRSIPTPSTLAVITMDPLKGNAVLEVDPSITFSIIDRLFGGTGQAAKVQRDLTDIENSVMEGVIVRILANVRESWTQVIDLRPRLGQIETNPQFAQIVPPSEMVVLVTLETKVGEEEGMMNFCIPYITIEPIISKLSSQFWFSSVRRSSTTQYMGVLRDKLSTVDMDVVAEVGSLRLSVRDILGLRVGDIIRLHDTHVGDPFVLSIGNRKKFLCQPGVVGKKIAAQILERIESTSQEDFEELSADEEELYE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q56342</accession>
    <accession>Q56341</accession>
    <name>MGLA_TREPA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="1">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mglA</name>
        <name type="ordered locus">TP_0685</name>
    </gene>
    <organism>
        <name type="scientific">Treponema pallidum (strain Nichols)</name>
        <dbReference type="NCBI Taxonomy" id="243276"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="DNA Seq." volume="6" first="293" last="298">
            <title>Identification and sequences of the Treponema pallidum mglA and mglC genes.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Young N.R."/>
                <person name="Frye J.G."/>
                <person name="Hardham J.M."/>
            </authorList>
            <dbReference type="PubMed" id="8988365"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Gene" volume="177" first="115" last="121">
            <title>A mgl-like operon in Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Porcella S.F."/>
                <person name="Popova T.G."/>
                <person name="Hagman K.E."/>
                <person name="Penn C.W."/>
                <person name="Radolf J.D."/>
                <person name="Norgard M.V."/>
            </authorList>
            <dbReference type="PubMed" id="8921855"/>
            <dbReference type="DOI" id="10.1016/0378-1119(96)00286-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1998" name="Science" volume="281" first="375" last="388">
            <title>Complete genome sequence of Treponema pallidum, the syphilis spirochete.</title>
            <authorList>
                <person name="Fraser C.M."/>
                <person name="Norris S.J."/>
                <person name="Weinstock G.M."/>
                <person name="White O."/>
                <person name="Sutton G.G."/>
                <person name="Dodson R."/>
                <person name="Gwinn M."/>
                <person name="Hickey E.K."/>
                <person name="Clayton R."/>
                <person name="Ketchum K.A."/>
                <person name="Sodergren E."/>
                <person name="Hardham J.M."/>
                <person name="McLeod M.P."/>
                <person name="Salzberg S."/>
                <person name="Peterson J."/>
                <person name="Khalak H."/>
                <person name="Richardson D."/>
                <person name="Howell J.K."/>
                <person name="Chidambaram M."/>
                <person name="Utterback T."/>
                <person name="McDonald L."/>
                <person name="Artiach P."/>
                <person name="Bowman C."/>
                <person name="Cotton M.D."/>
                <person name="Fujii C."/>
                <person name="Garland S."/>
                <person name="Hatch B."/>
                <person name="Horst K."/>
                <person name="Roberts K."/>
                <person name="Watthey L."/>
                <person name="Weidman J."/>
                <person name="Smith H.O."/>
                <person name="Venter J.C."/>
            </authorList>
            <dbReference type="PubMed" id="9665876"/>
            <dbReference type="DOI" id="10.1126/science.281.5375.375"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Nichols</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="1"/>
    <dbReference type="EMBL" id="U45323">
        <property type="protein sequence ID" value="AAC44749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="U48416">
        <property type="protein sequence ID" value="AAC44585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE000520">
        <property type="protein sequence ID" value="AAC65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC5170">
        <property type="entry name" value="JC5170"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010882130.1">
        <property type="nucleotide sequence ID" value="NC_021490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q56342"/>
    <dbReference type="SMR" id="Q56342"/>
    <dbReference type="IntAct" id="Q56342">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243276.TPANIC_0685"/>
    <dbReference type="EnsemblBacteria" id="AAC65648">
        <property type="protein sequence ID" value="AAC65648"/>
        <property type="gene ID" value="TP_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="tpa:TP_0685"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_12"/>
    <dbReference type="OMA" id="AKREIYQ"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000000811">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51260">
        <property type="entry name" value="MGLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092518" description="Galactose/methyl galactoside import ATP-binding protein MglA">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="243"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC44749." evidence="2" ref="1">
        <original>F</original>
        <variation>L</variation>
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="496" mass="55191" checksum="B6F63D53C5CD1411" modified="1996-11-01" version="1">MCDVLTIRDLSKSFARNRVLNGVNFRMGKGAVVGLMGENGAGKSTLMKCLFGMYAKDTGQILVDGSPVDFQSPKEALENGVAMVHQELNQCLDRTVMDNLFLGRYPARFGIVDEKRMFDDSLTLFASLKMDVNPRAVMRSMSVSQRQMVEIAKAMSYNAKIIVLDEPTSSLTEREIVRLFAIIRDLSKKGVAFIYISHKMDEIFQICSEVIVLRDGVLTLSQSIGEVEMSDLITAMVGRTLDKRFPDADNTVGDDYLEIRGLSTRYAPQLRDISLSVKRGEIFGLYGLVGAGRSELLEAIFGLRTIADGEISLAGKKIRLKSSRDAMKLNFAFVPEERKLNGMFAKGSIEYNTTIANLPAYKRYGLLSKKKLQEAAEREIKAMRVKCVSPSELISALSGGNQQKVIIGKWLERDPDVLLLDEPTRGIDVGAKYEIYQLIIRMAREGKTIIVVSSEMPEILGITNRIAVMSNYRLAGIVDTKSTDQEALLRLSARYL</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>